Polarizing agent for DNP-NMR, method for producing the same, and method of use.

JP7880149B2Active Publication Date: 2026-06-25OSAKA UNIVERSITY
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Patent Information

Application Number
JP2023543916
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-08-23
Filing Date
2022-08-22
Publication Date
2026-06-25
Estimated Expiration
2042-08-22

AI Technical Summary

Benefits of technology

【0010】 本発明の分極剤は、還元的環境においてもDNP-NMR法によってNMR信号を選択的に増強することができる。

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Abstract

Provided are polarizing agent with which it is possible to selectively enhance an NMR signal by using a DNP-NMR method even in a reductive environment, and a method for selectively enhancing an NMR signal.　The present invention is a polarizing agent used in a DNP-NMR method, the polarizing agent containing nanodiamond particles, and the surfaces of the nanodiamond particles being modified using a functional group capable of covalently bonding with or interacting with proteins. This polarizing agent makes it possible to selectively enhance an NMR signal by using a DNP-NMR method even in a reductive environment.
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Claims

1. A polarizer used in the DNP-NMR method, Contains nanodiamond particles, The nanodiamond particles are a DNP-NMR polarizer, wherein their surface is modified with at least one functional group selected from the group consisting of -C=C-, -COOH, -NH₂, -S-S-Py (where Py represents a pyridine ring), and biotin-derived groups.

2. The DNP-NMR polarizer according to claim 1, wherein the nanodiamond particles are further modified with charged groups.

3. A DNP-NMR polarizer according to claim 1 or 2, comprising the functional group and a protein bound together.

4. A method for producing a DNP-NMR polarizer according to claim 1 or 2, A method for producing a compound, comprising the step of modifying it with a compound having the aforementioned functional group.

5. A method for using a DNP-NMR polarizer according to claim 1 or 2, A method of use comprising enhancing the NMR signal by binding a target protein to the aforementioned functional group.

Citation Information

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  • System and method for imaging nanodiamonds as dynamic nuclear polarization agent

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  • Radical compounds and methods of using thereof

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  • Nano-diamond particle and method for producing same, and fluorescent molecular probe and method for analyzing structure of protein

    WO2014058012A1