Method for treating dermatitis of parasitic etiology in carnivores

Abstract

FIELD: veterinary science.SUBSTANCE: used to treat dermatitis of parasitic etiology in carnivores. The medications selamectin and fipronil are applied to the skin between the shoulder blades at the base of the animal’s neck. After which they are treated with a solution of ethyl alcohol. Next, using a sprayer, the surface is treated with electrochemically activated water with an acidic fraction with a pH of 2.0 in the amount of 20 ml per 15–20 cm2 for 15–18 s from a distance of 15–18 cm, then held for 40 min, after which the surface is treated with electrochemically activated water with an alkaline fraction with a pH of 9.0 in the amount of 20 ml per 10–12 cm2 for 15–18 s from a distance of 15–18 cm. The treatment is carried out twice a day until the skin heals.EFFECT: method provides for combined highly effective eradication of ectoparasites and suppression of pathogenic microflora with simultaneous acceleration of regeneration of damaged tissues due to the synergistic action of systemic-contact insectoacaricides and sequential local treatment of affected areas of the skin with electrochemically activated solutions with regulated acid-base balance.1 cl, 1 dwg

Description

[0001] The invention relates to veterinary medicine and can be used to treat dermatitis in animals.

[0002] Technology Level

[0003] A method for treating skin diseases in sheep is known, which includes preparing the affected areas of the skin, treating the affected areas with electrochemically activated water using a sprayer, an acidic fraction, holding for 25-30 minutes, followed by treatment with an alkaline fraction, characterized in that the prepared affected areas of the skin are pre-treated with a solution of ethyl alcohol at a concentration of 70%, then using a sprayer they are treated with an acidic fraction with a pH of 3.0 in an amount of 20-30 ml per 10 cm 2 surface for 10-15 s from a distance of 15-20 cm and subsequent treatment with an alkaline fraction with a pH of 11.0, in the amount of 20-30 ml per 10 cm 2 surfaces for 10-15 seconds from a distance of 15-20 cm, with the treatment being carried out twice a day (patent RU 2501576, published 20.12.2013, Bulletin No. 35).

[0004] The disadvantage of this treatment method is its low efficiency.

[0005] The closest in technical essence and the achieved positive effect and adopted by the authors as a prototype, is a method for treating skin diseases in sheep, including the preparation of affected areas of the skin, treatment of the affected areas with electrochemically activated water using a sprayer, an acidic fraction, holding for 25-30 minutes, followed by treatment with an alkaline fraction, characterized in that the prepared affected areas of the skin are pre-treated with a solution of ethyl alcohol at a concentration of 70%, then using a sprayer they are treated with an acidic fraction with a pH of 3.0 in an amount of 20-30 ml per 10 cm 2 surface for 10-15 seconds at a distance of 15-20 cm and subsequent treatment with an alkaline fraction with a pH of 11.0, in the amount of 20-30 ml per 10 cm 2surfaces for 10-15 seconds from a distance of 15-20 cm, with the treatment being carried out twice a day (patent RU 2501576, published 20.12.2013, Bulletin No. 35).

[0006] The disadvantage of this treatment method is its low efficiency.

[0007] Disclosure of invention

[0008] The objective of the proposed invention is to develop a method for treating dermatitis of parasitic etiology in carnivores.

[0009] The technical result that can be achieved with the help of the proposed invention is to increase the effectiveness of treatment.

[0010] The technical result is achieved using a method for treating dermatitis of parasitic etiology in carnivorous animals, including applying selamectin at a dosage of 15 ml / kg to dry skin between the shoulder blades at the base of the animal's neck and fipronil at a dosage of 0.5 ml / kg, after which the affected areas of the skin are prepared by treating with a solution of ethyl alcohol at a concentration of 70% and electrochemically activated water using a sprayer, at the beginning with an acidic fraction with a pH of 2.0 in an amount of 20 ml per 15-20 cm 2 surface for 15-18 seconds from a distance of 15-18 cm, then hold for 40 minutes, followed by treatment with an alkaline fraction with a pH of 9.0 in the amount of 20 ml per 10-12 cm 2 surface for 15-18 seconds from a distance of 15-18 cm. Treatment is carried out twice a day.

[0011] Electrochemically activated water (ECA water) is water that has undergone electrolysis, resulting in solutions with varying pH levels (acidic and alkaline). ECA water has antiseptic and healing properties.

[0012] Types of activated water and their pH:

[0013] - Alkaline water (catholyte): Produced at the cathode, it has a pH of about 8-9. It has antioxidant properties and is used to restore the body and increase vitality.

[0014] - Acidic water (anolyte): Produced at the anode, it has a pH of about 2-3. This water has bactericidal properties and is used for disinfection.

[0015] Electrochemically activated water (ECA water) is water that has undergone electrolysis, resulting in solutions with varying pH levels (acidic and alkaline). ECA water has antiseptic and healing properties.

[0016] Selamectin is a broad-spectrum antiparasitic agent. Selamectin has a broad spectrum of systemic nematocidal, insecticidal, and acaricidal action, and is active against nematodes, insects, and sarcoptic mites that infest dogs and cats. It also has larvicidal and ovocidal properties. The drug's mechanism of action is based on selamectin's ability to bind to receptors on parasite cells (muscle and nerve tissue), increasing membrane permeability to chloride ions, which leads to conduction blockade of the nerve and muscle cells of nematodes and arthropods, their paralysis, and death. At recommended doses, it is safe for dogs and cats because in mammals, these receptors are localized only in the central nervous system, and selamectin does not penetrate the blood-brain barrier. Well tolerated by cats and dogs of various breeds (including collies and their crossbreeds).

[0017] Fipronil is a phenylpyrazole insecticidal acaricidal medicinal product. It exhibits pronounced activity against the preimaginal and imaginal stages of fleas, lice, chewing lice, and ticks (Ixodid, Sarcoptoid, and Cheyletiella) that infest dogs, cats, ferrets, and rodents. Fipronil acts by disrupting the passage of chloride ions through GABA-dependent receptors in the ectoparasite, impairing nerve impulse transmission and nervous system function, leading to paralysis and death of the arthropods.

[0018] Brief description of drawings

[0019] Figure 1 (table) - Results of treatment of dermatitis of parasitic etiology in carnivores.

[0020] Implementation of the invention

[0021] The method for treating dermatitis of parasitic etiology in carnivores is as follows. To treat animals for fleas, ixodid mites, and scabies mites, selamectin is applied at a dosage of 15 ml / kg to dry skin between the shoulder blades at the base of the animal's neck, and fipronil at a dosage of 0.5 ml / kg. This is achieved by 2-4 presses for a 100 ml bottle and 1 press (1.0 ml) on the spray head of a 200 ml bottle, respectively.

[0022] Next, prepare the affected areas of the skin. The affected areas are pre-treated with a 70% ethyl alcohol solution. Next, treat the affected areas with electrochemically activated water using a spray bottle, first with an acidic fraction with a pH of 2.0 at a rate of 20 ml per 15-20 cm. 2surface for 15-18 seconds from a distance of 15-18 cm. Then, hold for 40 minutes, followed by treatment with an alkaline fraction with a pH of 9.0 in an amount of 20 ml per 10-12 cm 2 surface for 15-18 seconds from a distance of 15-18 cm. Treatment is carried out twice a day.

[0023] Examples of specific implementation of the method.

[0024] Five groups of sick animals, each with three heads, were formed, selected based on the principle of analogs, which were then subjected to treatment. Selamectin was applied at a dosage of 15 ml / kg to dry skin between the shoulder blades at the base of the neck of cats and dogs, and fipronil at a dosage of 0.5 ml / kg. Then, the affected areas of the skin were pre-treated with a solution of ethyl spit at a concentration of 70%. Then, the affected areas of the skin were treated with electrochemically activated water using a sprayer, initially with an acidic fraction with a pH of 3.0 at a rate of 10-15 ml per 5-15 cm 2surface for 10-20 seconds from a distance of 10-15 cm. Then, they were left to stand for 20-30 minutes, followed by treatment with an alkaline fraction with a pH of 11.0 in an amount of 10-15 ml per 5-10 cm 2 surface for 10-20 seconds from a distance of 10-15 cm. Treatment is carried out twice a day.

[0025] Traditional medications were used in experimental groups 3 and 4: tetracycline ointment, streptomycin emulsion, Vishnevsky ointment, and Cubatol. Group 5 served as the control group.

[0026] The experimental and control animals were subjected to daily clinical observation.

[0027] In the lesions of dogs in the first group, exudation and proliferation of the infiltrate were observed on days 2-5, and in cats in the second group, on days 3-5. Complete healing of the skin defects in both groups occurred within 6-10 days.

[0028] Treatment of dogs in groups three and four was performed using ECA water according to the following protocol: for two days (in the morning and afternoon), the affected skin areas were sprayed with the acidic fraction of ECA water, kept for 20-30 minutes, and then liberally irrigated with the alkaline fraction of ECA water. Further treatment was continued with the alkaline fraction of ECA water until complete healing of the skin defects. Some dogs and cats experienced partial exudation of skin areas within 1-2 days, while most animals experienced a reduction in the affected area. Complete healing of the skin defects occurred within 4-6 days (Table).

[0029] Healing of skin lesions in dogs and cats in the control groups 5 and 6 occurred within 3-4 weeks. In most affected animals in these groups, dermatitis progressed to dermatoses.

[0030] Treatment of dogs and cats with dermatoses, using either traditional therapies or ECA water, has not yielded significant positive results. Therefore, we recommend promptly treating dermatitis with acidic and alkaline fractions of ECA water to prevent the formation of scar tissue at the site of skin lesions and prevent the progression of dermatitis to dermatoses.

[0031] Compared with the prototype, the declared technical solution has the following advantages:

[0032] - Effective treatment.

[0033] - Reduced recovery time compared to conventional methods.

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