Complex sensor capable of measuring two or more analytes

Abstract

According to various embodiments, a complex sensor may be provided, the complex sensor comprising: a first sensor comprising a first substrate, including a first body and a first probe, a first electrode, and a first sensing layer disposed on the first probe; a second sensor comprising a second substrate, including a second body and a second probe, a second electrode, and a second sensing layer disposed on the second probe; and a counter electrode disposed between the first sensor and the second sensor, wherein when the first sensing layer comes into contact with an analyte in the body, the counter electrode causes a first potential difference from the first electrode on the basis of a first component included in the analyte, and when the second sensing layer comes into contact with the analyte, the counter electrode causes a second potential difference from the second electrode on the basis of a second component included in the analyte.

Description

A composite sensor capable of measuring two or more analytes

[0001] The present invention relates to a composite sensor capable of measuring two or more analytes, and more particularly, to a composite sensor capable of detecting two or more analytes contained in a body.

[0002]

[0003] Traditionally, diabetic patients measured their glucose levels by periodically analyzing blood samples taken from certain parts of the body. However, this method was not only painful for patients, but also inconvenient, requiring them to undergo periodic blood sampling.

[0004] Accordingly, the modern medical industry is increasingly demanding continuous glucose monitoring technology (CGMS), which can continuously measure blood sugar levels while attached to the user's body for a set period of time. CGMS measures glucose concentrations using a sensor that can come into contact with the interstitial fluid within the body.

[0005] This study was supported by the National Research and Development Program of the Ministry of Science and ICT of Korea and the Korea Foundation for the Advancement of Medical Devices (KFDM). As part of the KFDM program, the research project “Development of an Ultra-Compact Continuous Glucose Monitor for Building a Smart Healthcare System” (Project ID: 1711174351, Project ID: 00141116) was conducted as part of the KFDM program.

[0006] This study was supported by the National Research and Development Program of the Ministry of Health and Welfare of Korea and the Korea Health Industry Development Institute, and was conducted as part of the Drug Delivery Therapy Technology Development Project, as part of the research project titled ‘Development of a Miniature Continuous Glucose Monitoring Device Linked to a Weekly Patch-Type Insulin Pump’ (Project Unique Number: 1465040368, Project Number: HI23C0048000123).

[0007]

[0008] Along with glucose, ketones are also indicators that can indicate the current status of a diabetic patient.

[0009] The problem to be solved according to the embodiment of the present specification is to more accurately measure the blood sugar status of a diabetic patient by providing a sensor of a novel structure capable of measuring both glucose and ketone.

[0010] The tasks of the present invention are not limited to the tasks mentioned above, and other tasks not mentioned will be clearly understood by those skilled in the art from the description below.

[0011] According to various embodiments, a first sensor (e.g., a first sensor (100) of FIG. 5) including a first substrate (e.g., a first substrate (121B) of FIG. 10) including a first body (e.g., a first body (101) of FIG. 4) and a first probe (e.g., a first probe (121) of FIG. 4) extending from the first body, a first electrode (e.g., a first electrode (121E) of FIG. 10) disposed on a surface of the first substrate in a first direction, and a first sensing layer (e.g., a first sensing layer (121S) of FIG. 10) electrically connected to the first electrode and disposed on the first probe; A second substrate (e.g., the second substrate (221B) of FIG. 10) including a second body (e.g., the second body (201) of FIG. 4) and a second probe (e.g., the second probe (221) of FIG. 5) disposed in an area extending from the second body, a second electrode (e.g., the second electrode (221E) of FIG. 10) disposed on a surface of the second substrate in a second direction opposite to the first direction), and a second sensor (e.g., the second sensor (200) of FIG. 5) including a second sensing layer (e.g., the second sensing layer (221S) of FIG. 10) electrically connected to the second electrode and disposed on the second probe; And a counter electrode (e.g., the counter electrode (931) of FIG. 10) disposed between the first sensor and the second sensor; a composite sensor configured such that when the first sensing layer comes into contact with an analyte in the body, the counter electrode causes a first potential difference with respect to the first electrode based on a first component included in the analyte, and when the second sensing layer comes into contact with the analyte, the counter electrode causes a second potential difference with respect to the second electrode based on a second component included in the analyte.

[0012]

[0013] The present invention can provide a sensor capable of measuring both glucose and ketones through a single assembly.

[0014] The effects according to the present invention are not limited to those exemplified above, and more diverse effects are included in this specification.

[0015] FIG. 1 is an example implementation of a continuous blood glucose measurement system using a sensor member according to various embodiments.

[0016] FIG. 2 is an example implementation of an applicator for applying a sensor member to a user according to various embodiments.

[0017] FIG. 3 is an example implementation of a body attachment unit of a continuous blood glucose measurement system using a sensor member according to various embodiments.

[0018] Fig. 4 is a diagram showing a sensor member in its entirety according to various embodiments. Fig. 5 is a diagram showing a first sensor and a second sensor.

[0019] FIG. 6 is a drawing showing a sensor member from different angles according to various embodiments.

[0020] FIG. 7 is a drawing showing a bent sensor member according to various embodiments.

[0021] Figure 8 is a drawing showing area A of Figure 6.

[0022] Fig. 9 is a cross-sectional view of the BB' section of Fig. 6.

[0023] Fig. 10 is a cross-sectional view of the AA' section of Fig. 8.

[0024] Fig. 11 is a cross-sectional view of the CC' section of Fig. 8.

[0025] Fig. 12 is a drawing showing a sensor member according to another embodiment.

[0026] FIG. 13 is a drawing showing a first surface of a sensor base according to various embodiments.

[0027] FIG. 14 is a drawing showing a second side of a sensor base according to various embodiments.

[0028] FIG. 15 is a drawing showing a folded sensor base according to various embodiments.

[0029] Figure 16 is a flowchart showing a manufacturing process of a sensor member according to various embodiments.

[0030] Fig. 17 is a drawing showing a via hole structure according to various embodiments.

[0031] The above-described objects, features, and advantages of the present invention will become more apparent through the following detailed description taken in conjunction with the accompanying drawings. However, the present invention is susceptible to various modifications and various embodiments. Therefore, specific embodiments will be illustrated in the drawings and described in detail below.

[0032] In the drawings, the thicknesses of layers and regions are exaggerated for clarity, and when an element or layer is referred to as "on" or "on" another element or layer, it includes not only the case where the element or layer is directly on top of the other element or layer, but also the case where another layer or other element is interposed. In principle, the same reference numerals represent the same elements throughout the specification. In addition, elements that have the same function within the scope of the same idea that appear in the drawings of each embodiment are described using the same reference numerals.

[0033] If a detailed description of a known function or configuration related to the present invention is deemed to unnecessarily obscure the gist of the present invention, such detailed description will be omitted. Furthermore, numbers (e.g., "first," "second," etc.) used throughout the description of this specification are merely identifiers used to distinguish one component from another.

[0034] Additionally, the suffixes "area", "part", and "sub" used in the description below are assigned or used interchangeably solely for the convenience of writing specifications, and do not have distinct meanings or roles in themselves.

[0035]

[0036] FIG. 1 illustrates an exemplary embodiment of a continuous blood glucose measurement system utilizing a sensor member according to various embodiments. FIG. 2 illustrates an exemplary embodiment of an applicator for applying a sensor member according to various embodiments to a user. FIG. 3 illustrates an exemplary embodiment of a body attachment unit of a continuous blood glucose measurement system utilizing a sensor member according to various embodiments.

[0037] According to various embodiments, the continuous blood glucose measurement device is configured to attach a body attachment unit (1000) having a sensor member (10) inserted into the body for continuous blood glucose measurement to the body through an applicator (5), and the applicator (5) is operated to insert and attach the body attachment unit (1000) to the body to continuously measure blood glucose from the body, and blood glucose measurement information periodically measured through the body attachment unit (1000) is configured to be transmitted to a separate terminal (3) and output.

[0038] The body attachment unit (1000) is assembled inside the applicator (5) and manufactured as a single unit product, and the structure is very simple to use in a way that minimizes additional work for the user when using the continuous blood glucose measurement device.

[0039] The body attachment unit (1000) is formed to be attachable to the body so as to extract body fluid and periodically measure blood sugar levels, and is formed so as to transmit the blood sugar measurement results to an external device such as an external terminal (3). This body attachment unit (1000) has a sensor member (10) that is inserted into the body at one end, and a wireless communication chip disposed therein so as to enable wireless communication with the external terminal (3), so that it can be manufactured in a usable form without the need to additionally connect a separate transmitter.

[0040] The applicator (5) is formed so that the body attachment unit (1000) is fixedly coupled to the inside, and operates to eject the body attachment unit (1000) to the outside by a pressure operation on the user's button (6).

[0041] At this time, the body attachment unit (1000) is assembled and manufactured in a state of being inserted into the inside of the applicator (5), and is configured to move in the external discharge direction and be attached to the body according to the operation of the applicator (5) by the user's operation.

[0042] That is, the sensor applicator assembly according to various embodiments is manufactured so that the body attachment unit (1000) is attached to the skin only by operating the applicator (5) with the body attachment unit (1000) inserted into the applicator (5) during the manufacturing stage, and is supplied to the user in this state, so that the user can attach the body attachment unit (1000) to the skin simply by operating the applicator (5) without any separate additional work to attach the body attachment unit (1000) to the skin. In particular, since the body attachment unit (1000) is equipped with a separate wireless communication chip, there is no need to combine a separate transmitter, so that it can be used more conveniently.

[0043] In various embodiments, by manufacturing and distributing the body attachment unit (1000) in a state of being inserted into the applicator (5) during the manufacturing stage, the process of the user removing the body attachment unit (1000) and inserting it into the applicator (5) is omitted, and the body attachment unit (1000) can be attached to the skin simply by manipulating the applicator (5), thereby dramatically improving usability, and in particular, contamination of the body attachment unit (1000) can be prevented, thereby improving the accuracy of blood glucose measurement.

[0044] The applicator (5) may be configured to have a separate protective cap (8) detachably attached so that external exposure is blocked while the body attachment unit (1000) is inserted inside the applicator (5), and the user may operate the applicator (5) only after detaching the protective cap (8) to externally discharge the body attachment unit (1000) toward the side from which the protective cap (8) was removed, thereby attaching it to the body.

[0045] At this time, an adhesive tape (1002) is attached to the body contact surface of the body attachment unit (1000) so that the body attachment unit (1000) can be attached to the body, and a release paper (not shown) is attached to the body contact surface of the adhesive tape (1002) to protect the adhesive tape (1002). The release paper of the adhesive tape (1002) can be formed to be separated and removed from the adhesive tape (1002) in the process of separating the protective cap (8) from the applicator (5). However, this is exemplary, and various implementation modifications are possible.

[0046] For example, the release liner of the adhesive tape (1002) may be configured such that one side thereof is adhered to the protective cap (8), and thus, when the user detaches the protective cap (8) from the applicator (5), the release liner of the adhesive tape (1002) is separated and removed together with the protective cap (8). Accordingly, when the user detaches the protective cap (8), the release liner of the adhesive tape (1002) is separated and removed, and thus, the applicator (5) can be operated in this state to attach the body attachment unit (1000) to the body.

[0047] In addition, the applicator (5) may be formed to couple and fix the body attachment unit (1000) when the body attachment unit (1000) is inserted therein, and to release the coupling and fixation state with respect to the body attachment unit (1000) when the body attachment unit (1000) is moved to the outside. Accordingly, when the body attachment unit (1000) is inserted and assembled inside the applicator (5), the body attachment unit (1000) is maintained in a fixed state, and when the applicator (5) is operated to externally discharge the body attachment unit (1000) so that it is attached to the skin, the coupling and fixation state of the applicator (5) and the body attachment unit (1000) is released, so that when the applicator (5) is separated in this state, it is separated from the body attachment unit (1000), and only the body attachment unit (1000) remains attached to the skin.

[0048] Meanwhile, the body attachment unit (1000) according to various embodiments may be configured such that the sensor member (10) and the wireless communication chip are activated by a separate switch means operated by the user. That is, after inserting and attaching the body attachment unit (1000) to the body through the applicator (5), the user may activate the body attachment unit (1000) by a switch means provided in the body attachment unit (1000), and from the time of activation, the sensor member (10) and the wireless communication chip are activated to measure the blood sugar level of the body and transmit the measurement result to the external terminal (3). At this time, the switch means operated by the user may be configured in various ways.

[0049] In addition, the body attachment unit (1000) is formed such that a sensor member (10) is placed inside a housing (1001), and one end of the sensor member (10) protrudes outward from the bottom surface of the housing (1001) so that it can be inserted and attached to the body. The sensor member (10) is composed of a sensor probe that is inserted into the body and a sensor body that is placed inside the housing (1001), and the sensor probe and the sensor body are bent to form one end and the other end of the sensor member (10), respectively.

[0050] At this time, a separate insertion guide needle (1050) can be detachably coupled to the housing (1001) so that the body insertion process of the sensor member (10) can be smoothly performed. The insertion guide needle (1050) is configured to surround one end of the sensor member (10) so that one end of the sensor member (10) can be stably inserted into the body, and to be inserted into the body together with the sensor member (10).

[0051] This insertion guide needle (1050) is detachably mounted in a direction that vertically penetrates the housing (1001) of the body attachment unit (1000), as illustrated in FIG. 3, and is formed in a form that surrounds the outside of the sensor member (10), and a needle head (1051) is formed at the upper end. This insertion guide needle (1050) is inserted into the body before the sensor member (10) when the body attachment unit (1000) is moved in the external discharge direction by the applicator (5), and assists in stably inserting the sensor member (10) into the skin. The insertion guide needle (1050) is coupled to a needle withdrawal body disposed inside the applicator (5) through the needle head (1051), and is formed so that after the body attachment unit (1000) is inserted and attached to the body by the operation of the applicator (5), it is withdrawn and removed from the body by the needle withdrawal body of the applicator (5).

[0052] After the insertion guide needle (1050) is withdrawn from the body, the body attachment unit (1000) remains inserted and attached to the body, and the sensor member (10) of the body attachment unit (1000) measures blood sugar information from body fluid while one end is inserted into the skin. To measure such blood sugar information, a plurality of electrode layers are formed on the sensor member (10), and each electrode layer is formed to be connected to an electrical contact of a separate external electronic device.

[0053] In the above and below descriptions of the present invention, the term "Continuous Glucose Monitoring System" (CGMS) is used for convenience of explanation, but the spirit of the present invention is not limited thereto. According to various embodiments of the present invention, the continuous glucose monitoring system can obtain information on not only glucose but also other analytes in the body and provide analysis results based on the information. In other words, the continuous glucose monitoring system of the present invention can obtain information on two or more analytes and analyze the information.

[0054] Below, a sensor member for obtaining information on two or more analytes in the body will be described.

[0055]

[0056] Figures 4 to 11 are drawings showing a sensor member (10) according to the first embodiment.

[0057] FIG. 4 is a diagram showing a sensor member as a whole according to various embodiments. FIG. 5 is a diagram showing a first sensor and a second sensor. FIG. 6 is a diagram showing a sensor member according to various embodiments from different angles. FIG. 7 is a diagram showing a bent sensor member according to various embodiments. FIG. 8 is a diagram showing area A of FIG. 6. FIG. 9 is a cross-sectional view taken along line BB' of FIG. 6. FIG. 10 is a cross-sectional view taken along line AA' of FIG. 8. FIG. 11 is a cross-sectional view taken along line CC' of FIG. 8.

[0058] Referring to FIGS. 4 to 11, the sensor member (10) may include a first sensor (100) and a second sensor (200). The sensor member (10) of FIGS. 4 to 11 may have the same configuration as all or part of the sensor member (10) of FIGS. 1 to 3.

[0059] According to various embodiments, the first sensor (100) and the second sensor (200) may be coupled. In one embodiment, the first sensor (100) and the second sensor (200) may be coupled to each other via an adhesive member (421). For example, in a vertical direction (e.g., -y-axis direction), an adhesive member (421) may be placed between the first sensor (100) and the second sensor (200). Here, the adhesive member (421) may use a solid adhesive or a liquid adhesive. In some embodiments, the adhesive member (421) may be provided as an elastic material. In other words, the first sensor (100), the adhesive member (421), and the second sensor (200) may be sequentially stacked.

[0060] According to various embodiments, the sensor member (10) can measure at least two or more analytes. In one embodiment, the first sensor (100) can measure the first analyte, and the second sensor (200) can measure the second analyte. Here, the first analyte and the second analyte can include different components. For example, the first sensor (100) can measure glucose, and the second sensor (200) can measure ketone. In addition to glucose and ketone, the sensor member (10) of the present invention can be configured to measure analytes including more diverse components, but for convenience of explanation, the following description will focus on the sensor member (10) for measuring glucose and ketone.

[0061] According to various embodiments, the sensor member (10) may include a body (301) and a probe (321) extending from the body (301). The body (301) may include a first body (101) of a first sensor (100) and a second body (201) of a second sensor (200), and the probe (321) may include a first probe (121) of the first sensor (100) and a second probe (221) of the second sensor (200).

[0062] According to various embodiments, the body (301) may be mounted within the above-described body attachment unit (1001) and electrically connected to a circuit board (not shown) within the body attachment unit (1001). The probe (321) may extend from the body (301) and be inserted into the body. An electrical signal generated when the probe (321) is inserted into the body and comes into contact with a body substance may be transmitted to the circuit board via the body (301). For this purpose, the probe (321) and the body (301) may be electrically connected. Here, the body substance that the probe (321) comes into contact with may mean interstitial fluid.

[0063] According to various embodiments, the first sensor (100) may include all or part of the first body (101), the first link (131), and the first probe (121). According to one embodiment, the first body (101) may be provided in a planar shape. A first contact (103) may be provided on and / or inside the first body (101). For example, the first contact (103) may be an area for electrically connecting with the body attachment unit (1001).

[0064] According to one embodiment, a first probe (121) may extend from the first body (101) in a first direction (-z-axis direction). For example, the first probe (121) may be provided as a small portion of a sensor member (10) to be inserted into the body. The first probe (121) may be inserted into the body in accordance with the operation of the applicator described above (e.g., the applicator (5) of FIG. 2). In one embodiment, the first probe (121) inserted into the body may come into contact with a substance in the body (e.g., interstitial fluid) and measure an analyte.

[0065] In one embodiment (referring to FIGS. 10 and 11 together), the first sensor (100) may include a first substrate (121B), a first electrode (121E) disposed on the first substrate (121B), a first sensing layer (121S) disposed on the first electrode (121E), and a first insulating layer (121I). For example, the first electrode (121E) and the first sensing layer (121S) may be sequentially disposed on a surface (e.g., a +y-axis direction surface) of the first sensor (100). Additionally, the first insulating layer (121I) may be disposed adjacent to the first sensing layer (121S). In one embodiment, the first electrode (121E) may extend from the first body (101) to the first probe (121). Alternatively, a pattern for electrical connection may be provided between the edge region (e.g., the -z-axis direction edge) of the first probe (121) and the first contact (103). For example, the first electrode (121E) may be, but is not limited to, a carbon electrode. In one embodiment, a first sensing layer (121S) may be arranged on the edge region of the first probe (121) in the first direction (e.g., the -z-axis direction). For example, the first sensing layer (121S) may include an enzyme for measuring the concentration of glucose and / or ketone. In addition, a membrane may be provided on the edge region of the first probe (121) in the first direction to cover the first electrode (121E) and / or the first sensing layer (121S).

[0066] In some embodiments, the first sensing layer (121S) and the second sensing layer (221S) may be arranged in parallel. For example, the first sensing layer (121S) and the second sensing layer (221S) may be arranged in parallel along the longitudinal direction (z-axis direction) of the first probe (121). In this case, since the first sensing layer and the second sensing layer are not partitioned by a substrate (the first substrate (121B) and / or the second substrate (221B)), a separate means may be provided to partition between the first sensing layer and the second sensing layer.

[0067] In FIG. 11, the first sensing layer (121S) is illustrated as being disposed at one end (the -z-axis direction end) of the first probe (121), but the present disclosure is not limited thereto. For example, the first sensing layer (121S) may be disposed at a predetermined distance from one end (the -z-axis direction end) of the first probe (121). In this case, a first insulating layer (121I) may be disposed at one end (the -z-axis direction end) of the first probe (121), and the first sensing layer (121S) may be surrounded by the first insulating layer (121I). It will be understood that the same description as that of the first sensing layer (121S) may also apply to the second sensing layer (221S).

[0068] According to various embodiments, the second sensor (200) may include all or part of the second body (201), the second link (231), and the second probe (221). According to one embodiment, the second body (201) may be provided in a planar shape. A second contact (203) may be provided on and / or inside the second body (201). For example, the second contact (203) may be an area for electrically connecting with the body attachment unit (1001).

[0069] According to one embodiment, a second probe (221) may extend from the second body (201) in the first direction (-z-axis direction). For example, the second probe (221) may be provided as a small portion of a sensor member (10) to be inserted into the body. The second probe (221) may be inserted into the body in accordance with the operation of the applicator described above (e.g., the applicator (5) of FIG. 2). In one embodiment, the second probe (221) inserted into the body may come into contact with an analyte (e.g., interstitial fluid) in the body and measure the analyte.

[0070] According to various embodiments (see also FIGS. 10 and 11), similar to the first sensor (100), the second sensor (200) may include a second substrate (221B), a second electrode (221E) disposed on the second substrate (221B), a second sensing layer (221S) disposed on the second electrode (221E), and a second insulating layer (221I). For example, the second electrode (221E) and the second sensing layer (221S) may be sequentially disposed on a surface (e.g., a +y-axis direction surface) of the second sensor (200). The second electrode (221E) may extend from the second body (201) to the second probe (221). Alternatively, a pattern for electrical connection may be provided between the edge region (e.g., the -z-axis direction edge) of the second probe (221) and the second contact (103). For example, the second electrode (221E) may be a carbon electrode, but is not limited thereto. In one embodiment, a second sensing layer (221S) may be arranged on the edge region of the second probe (221) in the first direction (e.g., the -z-axis direction). For example, the second sensing layer may include an enzyme for measuring the concentration of glucose and / or ketone. If the first sensing layer (121S) includes an enzyme for measuring glucose, the second sensing layer (221S) may include an enzyme for measuring ketone. Additionally, a membrane may be provided on the second directional edge region of the second probe (221) to cover the second electrode (221E) and / or the second sensing layer (221S). For example, when the first sensing layer (121S) comes into contact with an analyte in the body, a potential difference is generated between the counter electrode (931) and the first electrode (121E) (and / or the first sensing layer (121S)), which can be used to measure the first component included in the analyte.As another example, when the second sensing layer (221S) comes into contact with an analyte in the body, a potential difference is generated between the counter electrode (931) and the second electrode (221E) (and / or the second sensing layer (221S)), which can be used to measure a second component included in the analyte. In this way, by sharing one counter electrode (931) with two or more electrodes (911, 921), two or more analytes can be measured with one counter electrode (931). In some embodiments, the first potential difference between the first electrode (121E) and the counter electrode (931) and / or the second potential difference between the second electrode (221E) and the counter electrode (931) may be generated simultaneously. Information related to the first potential difference and the second potential difference is transmitted to the body attachment unit (1000), and the body attachment unit (1000) can detect the first component and the second component based on the first potential difference and the second potential difference.

[0071] According to various embodiments (mainly referring to FIGS. 6 and 8), a counter electrode (401) may be disposed between the first sensor (100) and the second sensor (200) in the vertical direction (e.g., the y-axis direction). For example, the counter electrode (401) may be a silver or silver chloride electrode, but is not limited thereto, and various counter electrodes performing a similar function may be used. Referring to FIGS. 10 and 11, the first electrode (121E) and / or the second electrode (221E) described above may be provided as a working electrode. In summary, it may be expressed that the first sensor (100) and the second sensor (200) may be substantially symmetrically disposed with the counter electrode (401) and / or the adhesive member (421) therebetween. Additionally, the first sensor (100) and the second sensor (200) are partitioned by a counter electrode (401) and / or an adhesive member (421), so that different analytes can be measured.

[0072] According to various embodiments, as illustrated in FIGS. 4, 5, and 7, the sensor member (10) may include a link (331) between the body (301) and the probe (321). The link (331) may be provided by a combination of a first link (131) of the first sensor (100) and a second link (231) of the second sensor (200). In one embodiment, a first neck (132) may be arranged between the first body (101) and the first link (131), and a second neck (232) may be arranged between the second body (201) and the second link (231). According to one embodiment, when the first sensor (100) and the second sensor (200) are overlapped, the first link (131) and the second link (231) may overlap, and the first neck (132) and the second neck (232) may not overlap each other. As illustrated in FIG. 7, when the first sensor (100) and the second sensor (200) are coupled, the bending area (B) near the boundary between the probe (321) and the link (331) may be bent. At this time, the first neck (132) and the second neck (232) are spaced apart from each other in the horizontal direction (x-axis direction), so that the first sensor (100) and the second sensor (200) that are coupled may be prevented from being misaligned even when the bending area (B) is bent.

[0073] In some embodiments, the sensor member (10) may include an overlapping region (O) as illustrated in FIG. 9. For example, the overlapping region (O) may refer to a region where the first sensor (100) and the second sensor (200) overlap each other when the body (301) of the sensor member (10) illustrated in FIG. 6 is viewed in a direction parallel to the y-axis. In one embodiment, at least a portion of the first contact (103) and at least a portion of the second contact (203) may not overlap each other in order to provide a via hole and / or be electrically connected to a circuit board. Accordingly, a part (109) of the first body (101) in which the first contact (103) is disposed on the first outer side (e.g., in the -x-axis direction) and a part (209) of the second body (201) in which the second contact (203) is disposed on the second outer side (e.g., in the +x-axis direction) may not overlap with each other in the y-axis direction. In other words, the first body (101) may include a first extension portion (109) extending from an overlapping area (O) in which the adhesive member (421) and the second body (201) are disposed to overlap with each other in the y-axis direction in the first outer direction, and the second body (201) may include a second extension portion (209) extending from the overlapping area (O) in the second outer direction. In addition, a common contact (305, see FIG. 4) may be disposed in the overlapping area (O). The common contact (305) may be provided as a combination of the first common contact (105, see FIG. 4) of the first sensor (100) and the second common contact (205, see FIG. 4) of the second sensor (200). The first common contact (105) may be at least a part of the first contact (103), and the second common contact (205) may mean at least a part of the second contact (203). The first common contact (105) and the second common contact (205) may be arranged to overlap each other in the vertical direction (y-axis direction). In addition, a via hole may be provided so as to connect the first common contact (105) and the second common contact (205).In some embodiments, the common contact (305) may be electrically connected to the counter electrode (401).

[0074] In some embodiments, the shapes of the first link (131) and the second link (231) may be different from each other. For example, as described above, when the first sensor (100) and the second sensor (200) are coupled, in order for the first neck (132) and the second neck (232) to be spaced apart from each other, the first neck (132) may extend in the -z-axis direction substantially near the center of the first link (131) (between the first side (131a) and the second side (131b), and the second neck (232) may extend while being connected to the first side (231a) of the second link (231). However, this is exemplary, and it will be understood that various implementation modifications are possible. For example, the second neck (232) may extend adjacent to the fourth side (231b).

[0075] According to various embodiments, the vertical direction (y-axis direction) thickness of the counter electrode (401) may substantially correspond to the vertical direction (y-axis direction) thickness of the adhesive member (421). Accordingly, when the first sensor (100) and the second sensor (200) are bonded, an unintended thickness change of the probe (321) due to a thickness difference between the adhesive member (421) and the counter electrode (401) may be prevented. According to one embodiment, the adhesive member (421) may include an insulating material including the same material as the first substrate (912, see FIG. 10) and / or the second substrate (922, see FIG. 10). In addition, the adhesive member (421) may include a polymer material that can be applied thinly in order to correspond in thickness to the counter electrode (401).

[0076] Referring to FIG. 10, the sensor member (10) is partitioned by a counter electrode (931) and may have a laminated structure including at least two or more substrates (912, 922). In addition, it may be expressed that the sensor member (10) may have two or more electrodes that share the counter electrode (931).

[0077] Referring to the illustrated example, with the counter electrode (931) as the center, a first substrate (121B) and a first electrode (121E) may be sequentially arranged in a first vertical direction (+y-axis direction), and a second substrate (221B) and a second electrode (221E) may be sequentially arranged in a second vertical direction (-y-axis direction). In one embodiment, the combination of the first substrate (121B), the first electrode (121E), and the counter electrode (931) may be provided as a means for measuring a first analyte (e.g., glucose), and the combination of the second substrate (221B), the second electrode (221E), and the counter electrode (931) may be provided as a means for measuring a second analyte (e.g., ketone). The first sensor (100) described above in FIGS. 4 to 9 may include a first substrate (121B) and a first electrode (121E), and the second sensor (200) may include a second substrate (221B) and a second electrode (221E).

[0078] In one embodiment, the first substrate (121B) and / or the second substrate (221B) may include an insulating material. For example, the first substrate (121B) and / or the second substrate (221B) may include a synthetic resin. Specifically, the first substrate (121B) and / or the second substrate (221B) may be a plastic substrate. However, this is merely exemplary, and various implementation modifications are possible.

[0079]

[0080] Fig. 12 is a drawing showing a sensor member according to another embodiment. Fig. 12 (a) is a perspective view of the sensor member (50), and Fig. 12 (b) is a perspective view of the sensor member (50) viewed from a different direction than (a).

[0081] Referring to Fig. 12, the counter electrode (401) may be exposed in at least a portion of the sensor member (50). The sensor member (50) of Fig. 12 may be applied to all or part of the description of the sensor member (10) of Figs. 4 to 11, unless otherwise specified.

[0082] According to various embodiments, the first direction (e.g., z-axis) lengths of the first sensor (500) and the second sensor (600) may be provided differently. In one embodiment, the first axis (z-axis) direction lengths of the first probe (521) and the second probe (621) may be different. For example, the second probe length (D2), which is the length of the second probe (621), may be shorter than the first probe length (D1), which is the length of the first probe (521). By providing the second probe length (D2) to be shorter than the first probe length (D1), the counter electrode (401) may be exposed to a part of the first direction (-z-axis direction) edge area of ​​the probe (592). As described below, as the counter electrode (401) is exposed, the number of via holes for electrical connection between the first electrode (e.g., the first electrode (121E) of FIG. 10), the counter electrode (401), and the second electrode (e.g., the second electrode (221E) of FIG. 10) may be reduced.

[0083] In other words, the sensor member (50) may overlap the first sensor (500) and the second sensor (600) with respect to the vertical direction (y-axis direction), except for the edge area of ​​the neck (582) and the probe (592).

[0084]

[0085] FIGS. 13 to 15 are drawings illustrating a manufacturing process of a sensor member according to another embodiment. FIG. 13 is a drawing illustrating a first side of a sensor base according to various embodiments. FIG. 14 is a drawing illustrating a second side of a sensor base according to various embodiments. FIG. 15 is a drawing illustrating a folded sensor base according to various embodiments.

[0086] Referring to FIGS. 13 to 15, a sensor member including two or more electrodes (e.g., the sensor member (50) of FIG. 12) may be provided by folding one substrate (60).

[0087] According to various embodiments, the substrate (60) may include a first substrate (700) and a second substrate (800). In one embodiment, the first substrate (700) may be an area corresponding to the first sensor described above (e.g., the first sensor (100) of FIGS. 3 to 11 and / or the first sensor (500) of FIG. 12), and the second substrate (800) may be an area corresponding to the second sensor described above (e.g., the second sensor (200) of FIGS. 3 to 11 and / or the second sensor (600) of FIG. 12).

[0088] According to various embodiments, a fold line (750) may be provided between the first substrate (700) and the second substrate (800). The fold line (750) may be provided by processing the surface of the substrate (60) and may enable the substrate (60) to be easily folded.

[0089] According to various embodiments, the substrate (60) may include a punch (751). The punch (751) may include all or part of the first punch (705), the second punch (805), and / or the intermediate punch (755). By providing the punch (751), when the substrate (60) is folded along the fold line (750), the shape of the sensor member (e.g., the sensor member (10) of FIG. 4 or the sensor member (50) of FIG. 12) described above may be completed. Here, the fold line (750) may reduce deformation of the substrate (60) when the punch (751) is processed into the substrate (60). In one embodiment, a portion of the substrate (60) between the intermediate punches (755) may be provided as a connecting region (756). The connection area (756) may refer to an area where the first substrate (700) and the second substrate (800) are connected. For example, when the substrate (60) is folded and a sensor member (e.g., a sensor member (50) of FIG. 12) is completed, the first sensor (e.g., the first sensor (500) of FIG. 12) and the second sensor (e.g., the second sensor (600) of FIG. 12) may be connected through a connection area (e.g., the connection area (556) of FIG. 12).

[0090] According to various embodiments, electrodes may be placed on a first surface (e.g., a surface facing the +y-axis direction) of the substrate (60). For example, a first electrode (701) may be placed on a first surface of a first substrate (700), and a second electrode (801) may be placed on a first surface of a second substrate (800).

[0091] According to various embodiments, the first substrate (700) may include a first trace (709) for electrically connecting to a first contact (707). Additionally, the second substrate (800) may include a second trace (809) for electrically connecting to a second contact (807).

[0092] Referring to FIG. 14, an adhesive member (891) and a counter electrode (841) may be disposed on a second surface (e.g., a surface facing the -y-axis direction) of the substrate (60). The counter electrode (841) may be disposed in an area of ​​the second surface facing the first electrode (701) and / or the second electrode (801) of the first surface. The adhesive member (891) may be disposed in another area of ​​the second surface where the counter electrode (841) is not disposed.

[0093] According to various embodiments, the substrate (60) may be folded along the fold line (750). Thereafter, the sensor member (69) may be separated from the substrate (60) so as to correspond to the shape of the sensor member (e.g., the sensor member (10) of FIG. 4 and / or the sensor member (50) of FIG. 12) (see FIG. 15).

[0094]

[0095] Figure 16 is a flowchart showing a manufacturing process of a sensor member according to various embodiments.

[0096] Referring to FIG. 16, the manufacturing process of the sensor member may include all or part of the steps of providing a first pattern in a first region of the substrate (S10), providing a second pattern in a second region of the substrate (S20), providing a counter electrode on the back surface of the substrate (S30), and folding the substrate along a folding region (S40). In describing FIG. 16, the reference numerals of FIGS. 12 to 15 may be applied together.

[0097] According to various embodiments, a first pattern (P1) may be provided in at least one area of ​​a first area of ​​the substrate (S10). Here, the first area may refer to an area corresponding to the first sensor (500) on a first surface (a surface located in the +Y-axis direction of FIG. 13) of the substrate (60). In addition, the first pattern (P1) may include a first electrode (701), a first contact (707), and a first trace (709) connecting the first contact (707) and the first electrode (701).

[0098] Similarly, a second pattern (P2) may be provided in a second region of the substrate (S20). Here, the second region may refer to a region corresponding to the second sensor (600) on the first surface (the surface located in the +Y-axis direction of FIG. 13) of the substrate (60). In addition, the second pattern (P1) may include a second electrode (801), a second contact (807), and a second trace (809) connecting the second contact (807) and the second electrode (801).

[0099] According to various embodiments, a counter electrode (841) may be provided on the second surface of the substrate (60). The counter electrode (841) may be provided on a portion of the substrate (60) corresponding to a probe (e.g., the first probe (121) and / or the second probe (221) of FIG. 5). Additionally, an adhesive member (891) may be disposed on the second surface of the substrate (60) where the counter electrode (841) is not disposed. Here, as described above, the counter electrode (841) and the adhesive member (891) may be disposed to have substantially the same height.

[0100] According to various embodiments, the substrate (60) on which the first pattern (P1), the second pattern (P2), and the counter electrode are arranged can be folded along the folding line (750). As the substrate (60) is folded, the first substrate (700) and the second substrate (800) are covered, and the outer shape of the substrate (60) can be processed to correspond to the shape of the various sensor members described above (e.g., the sensor member (10) of FIG. 4).

[0101]

[0102] Fig. 17 is a drawing showing a via hole structure according to various embodiments.

[0103] Referring to FIG. 17, an electrode (e.g., a first electrode (121E) or a second electrode (221E)) and a counter electrode (931) can be electrically connected through a via hole. The via hole structure illustrated in FIG. 16 can be provided in a body (301) and / or a probe (321) of a sensor member (e.g., a sensor member (10) of FIG. 4).

[0104] In one embodiment, the first electrode (121E) may be electrically connected to the counter electrode (931) through a via hole, and / or the second electrode (221E) may be electrically connected to the counter electrode (931) through a via hole. The via hole structure of FIG. 16 may be applied to the sensor member in the above-described embodiments (e.g., the sensor member (10) of FIG. 4, the sensor member (50) of FIG. 11).

[0105] According to various embodiments, the first electrode (121E) and the counter electrode (931) may be connected through a first via hole (951). The first via hole (951) may be formed by penetrating all or part of the first electrode (121E), the first substrate (917), and the counter electrode (931). A first conductive material (952) may be applied around the first via hole (922), through which the first electrode (121E) and the counter electrode (931) may be electrically connected. In addition, the second electrode (221E) and the counter electrode (931) may be connected through a second via hole (961). The second via hole (961) may be formed by penetrating all or part of the second electrode (221E), the second substrate (938), and the counter electrode (931). Similarly, the second electrode (221E) and the counter electrode (931) can be electrically connected through the first conductive material (962) provided around the second via hole (961).

[0106] According to various embodiments, when viewed from above the sensor member (90) (when viewed parallel to the y-axis), the first via hole (951) and the second via hole (961) may be arranged so as not to overlap each other. In other words, the first via hole (951) and the second via hole (961) may be arranged to be spaced apart from each other in the longitudinal direction (z-axis direction). Through this, electrical interference between the first via hole (951) and the second via hole (961) may be prevented.

[0107] According to various embodiments, the depth of the first via hole (951) and / or the second via hole (961) may be set to various depths. For example, the first via hole (951) may extend to the inside of the counter electrode (931). As another example, the first via hole (951) may extend to the surface (+y-axis direction surface) of the counter electrode (931). At this time, the first conductive material (952) may be applied on the surface of the counter electrode (931). Similar to the first via hole (951), the second via hole (961) may extend to the inside of the counter electrode (931) or may extend to the surface (-y-axis direction surface) of the counter electrode (931).

[0108] According to various embodiments, a first sensor (e.g., a first sensor (100) of FIG. 5) including a first substrate (e.g., a first substrate (121B) of FIG. 10) including a first body (e.g., a first body (101) of FIG. 4) and a first probe (e.g., a first probe (121) of FIG. 4) extending from the first body, a first electrode (e.g., a first electrode (121E) of FIG. 10) disposed on a surface of the first substrate in a first direction, and a first sensing layer (e.g., a first sensing layer (121S) of FIG. 10) electrically connected to the first electrode and disposed on the first probe; A second substrate (e.g., the second substrate (221B) of FIG. 10) including a second body (e.g., the second body (201) of FIG. 4) and a second probe (e.g., the second probe (221) of FIG. 5) disposed in an area extending from the second body, a second electrode (e.g., the second electrode (221E) of FIG. 10) disposed on a surface of the second substrate in a second direction opposite to the first direction), and a second sensor (e.g., the second sensor (200) of FIG. 5) including a second sensing layer (e.g., the second sensing layer (221S) of FIG. 10) electrically connected to the second electrode and disposed on the second probe; And a counter electrode (e.g., the counter electrode (931) of FIG. 10) disposed between the first sensor and the second sensor; a composite sensor configured such that when the first sensing layer comes into contact with an analyte in the body, the counter electrode causes a first potential difference with respect to the first electrode based on a first component included in the analyte, and when the second sensing layer comes into contact with the analyte, the counter electrode causes a second potential difference with respect to the second electrode based on a second component included in the analyte.

[0109] According to one embodiment, in order to detect the first component and the second component based on the first potential difference and the second potential difference, the composite sensor may be provided as a composite sensor electrically connectable to an external device.

[0110] According to one embodiment, a composite sensor may be provided that further includes a via hole (e.g., the first via hole (951) of FIG. 17) for electrical connection between the first electrode and the counter electrode or between the second electrode and the counter electrode.

[0111] According to one embodiment, a composite sensor may be provided in which the via hole includes a first via hole connecting the first electrode and the counter electrode and a second via hole connecting the second electrode and the counter electrode.

[0112] According to one embodiment, the first via hole and the second via hole may be provided with a composite sensor spaced apart from each other so that they do not overlap each other when viewed from above the composite sensor.

[0113] In one embodiment, a composite sensor may be provided in which the length of the first probe is shorter than the length of the second probe, such that a portion of the counter electrode is exposed outside the composite sensor.

[0114] According to a probe embodiment, a composite sensor may be provided in which the first sensor includes a first link (e.g., the first link (132) of FIG. 5) disposed between the first body and the first probe, and the second sensor includes a second link (e.g., the second link (232) of FIG. 5) disposed between the second body and the second probe.

[0115] According to one embodiment, the first sensor includes a first neck (e.g., the first neck (133) of FIG. 5) for connecting between the first link and the first body, the second sensor includes a second neck (e.g., the second neck (233) of FIG. 5) for connecting between the second link and the second body, and when viewed from above the composite sensor, the first neck and the second neck may be spaced apart from each other, so that a composite sensor may be provided.

[0116] According to one embodiment, a composite sensor may be provided in which the counter electrode is disposed between an edge of the first probe and an edge of the second probe, an adhesive member (e.g., an adhesive member (421) of FIG. 8) is disposed parallel to the counter electrode between the first substrate and the second substrate with respect to the second direction, and the adhesive member and the counter electrode are disposed to have substantially the same thickness.

[0117] According to one embodiment, a composite sensor may be provided in which the adhesive member is provided as an insulating material comprising the same material as the first sensor or the second sensor.

[0118] According to one embodiment, a composite sensor may be provided in which the first substrate and the second substrate are connected through a connecting portion (e.g., connecting portion (556) of FIG. 11).

[0119] In one embodiment, a composite sensor may be provided wherein the first component comprises glucose and the second component comprises a ketone.

[0120] According to one embodiment, the first probe and the second probe may be provided as a composite sensor that is bent to face in different directions from the first body and the second body.

[0121] According to one embodiment, the composite sensor may be provided such that, when viewed from above, the composite sensor includes an overlapping region (e.g., an overlapping region (O) of FIG. 9) in which at least a portion of the first body and at least a portion of the second body are overlapped.

[0122] According to one embodiment, a composite sensor may be provided in which the first body includes a first extension portion (e.g., the first extension portion (109) of FIG. 9) extending in a third direction from the overlapping area and not overlapping with the second body, and the second body includes a second extension portion (e.g., the second extension portion (209) of FIG. 9) extending in an opposite direction from the overlapping area and not overlapping with the first body.

[0123] According to one embodiment, the first contact and the second contact may be provided with a composite sensor provided within the overlapping region.

[0124] According to one embodiment, a composite sensor may be provided in which at least a portion of the first contact is disposed in the first extension portion and at least a portion of the second contact is disposed in the second extension portion.

[0125] According to various embodiments, in a manufacturing process of a composite sensor, a manufacturing process of a composite sensor may be provided, including: a step of arranging an electrode on a first surface of a substrate including a first region and a second region, wherein a first electrode including a first sensing layer for contacting interstitial fluid in the body and measuring a first component is arranged in the first region, a second electrode including a second sensing layer for contacting interstitial fluid in the body and measuring a second component different from the first component is arranged in the second region, a step of arranging a counter electrode on a second surface of the substrate opposite to the first surface; a step of arranging an adhesive member on the second surface of the substrate so as not to overlap with the counter electrode; and a step of folding the substrate along a folding line provided between the first region and the second region.

[0126] According to one embodiment, a manufacturing process of a composite sensor may be provided, further comprising a step of forming a punch (e.g., a first punch (705) of FIG. 12) on the substrate to provide an appearance of the composite sensor.

[0127] According to one embodiment, a manufacturing process of a composite sensor may be provided in which the counter electrode and the adhesive member are arranged to have substantially the same height.

[0128]

[0129] Although the embodiments described above have been described by way of limited examples and drawings, those skilled in the art will appreciate that various modifications and variations can be made based on the above description. For example, appropriate results can still be achieved even if the described techniques are performed in a different order than described, and / or components of the described systems, structures, devices, circuits, etc. are combined or combined in a different manner than described, or are replaced or substituted with other components or equivalents.

[0130] Therefore, other implementations, other embodiments, and equivalents to the claims also fall within the scope of the claims described below.

[0131]

[0132] 3 terminals

[0133] 5 applicators

[0134] 6 buttons

[0135] 8 protective caps

[0136] 10, 50 sensor absence

[0137] 1000 body attachment units

[0138] 1001 Housing

[0139] 1050 guide needle

[0140] 1051 Needle Head

[0141] 100, 500 first sensor

[0142] 200, 600 second sensor

[0143] 421 Adhesive member

[0144] 301 body

[0145] 303 Contact

[0146] 305 Common Contact

[0147] 321 probe

[0148] 331 links

[0149] 332 neck

[0150] 101 First Body

[0151] 103 First Contact

[0152] 105 First common contact

[0153] 109 First extension section

[0154] 201 Second Body

[0155] 203 Second Contact

[0156] 205 Second Common Contact

[0157] 209 Second extension section

[0158] 121 First Probe

[0159] 131 First Link

[0160] 132 1st neck

[0161] 221 Second Probe

[0162] 231 Second Link

[0163] 232 2nd neck

[0164] 121E 1st electrode

[0165] 121B No. 1

[0166] 121S 1st sensing layer

[0167] 121I first insulation layer

[0168] 221E Second Electrode

[0169] 221B Second Report

[0170] 221S 2nd Sensing Layer

[0171] 221I second insulation layer

[0172] 401, 931 counter electrode

[0173] 60 descriptions

[0174] 751 Tabal

[0175] 705 First shot

[0176] 805 Second Tabal

[0177] 755 medium stroke

[0178] 750 fold line

[0179] 556, 756 connection area

[0180] 709 First Trace

[0181] 809 Second Trace

[0182] 891 Adhesive member

[0183] 951 First Via Hall

[0184] 952 First conductive material

[0185] 961 2nd Via Hall

[0186] 962 Second conductive material

Claims

1. In a composite sensor for measuring at least two analytes, A first sensor comprising a first substrate including a first body and a first probe extending from the first body, a first electrode disposed on a surface of the first substrate located in a first direction, and a first sensing layer electrically connected to the first electrode and disposed on the first probe; A second sensor including a second substrate including a second body and a second probe disposed in an area extending from the second body, a second electrode disposed on a surface of the second substrate located in a second direction opposite to the first direction, and a second sensing layer electrically connected to the second electrode and disposed on the second probe; and a counter electrode disposed between the first sensor and the second sensor; When the first sensing layer comes into contact with an analyte in the body, the counter electrode is configured to cause a first potential difference with the first electrode based on a first component included in the analyte, and when the second sensing layer comes into contact with the analyte, the counter electrode is configured to cause a second potential difference with the second electrode based on a second component included in the analyte. Complex sensor.

2. In paragraph 1, In order to detect the first component and the second component based on the first potential difference and the second potential difference, the composite sensor is electrically connectable to an external device. Complex sensor.

3. In paragraph 1, Further comprising a via hole for electrical connection between the first electrode and the counter electrode or between the second electrode and the counter electrode. Complex sensor.

4. In paragraph 3, The above via hole includes a first via hole extending through the first substrate from the first electrode to the counter electrode and a second via hole extending through the second substrate from the second electrode to the counter electrode. Complex sensor.

5. In paragraph 4, The first via hole and the second via hole are spaced apart from each other so that they do not overlap when the composite sensor is viewed parallel to the first direction. Complex sensor.

6. In paragraph 4, The above composite sensor includes a first conductive material provided on the inner wall of the first via hole and a second conductive material provided on the inner wall of the second via hole. Complex sensor.

7. In paragraph 1, The length of the first probe is shorter than the length of the second probe so that a portion of the counter electrode is exposed outside the composite sensor. Complex sensor.

8. In paragraph 1, The first sensor includes a first link disposed between the first body and the first probe, The second sensor includes a second link disposed between the second body and the second probe, Complex sensor.

9. In paragraph 8, The first sensor includes a first neck for connecting the first link and the first body, The second sensor includes a second neck for connecting the second link and the second body, When viewed from above the above composite sensor, the first neck and the second neck are spaced apart from each other, Complex sensor.

10. In paragraph 1, The counter electrode is placed between one end of the first probe and one end of the second probe, An adhesive member is arranged parallel to the counter electrode between the first substrate and the second substrate in the second direction, The adhesive member and the counter electrode are arranged to have substantially the same thickness, Complex sensor.

11. In paragraph 10, The adhesive member comprises an insulating material comprising the same material as the material included in the first sensor or the second sensor. Complex sensor.

12. In paragraph 1, The above first substrate and the above second substrate are connected through a folding portion. Complex sensor.

13. In paragraph 1, The first component comprises glucose, The second component contains a ketone. Complex sensor.

14. In paragraph 1, The first probe and the second probe are bent to face different directions from the first body and the second body. Complex sensor.

15. In paragraph 1, The above composite sensor includes an overlapping area in which at least a portion of the first body and at least a portion of the second body are overlapped when viewed parallel to the first direction. composite sensor 16. In paragraph 15, The first body includes a first extension portion extending in a third direction from the overlapping area and not overlapping the second body, The second body includes a second extension portion extending opposite to the third direction from the overlapping area and not overlapping with the first body. Complex sensor.

17. In paragraph 15, The first sensor includes a first contact for electrical connection with another device, The second sensor includes a second contact for electrically connecting with the other device, At least a portion of the first contact and the second contact are provided within the overlapping area. Complex sensor.

18. In paragraph 16, The first sensor includes a first contact for electrical connection with another device, The second sensor includes a second contact for electrically connecting with the other device, At least a portion of the first contact is disposed in the first extension portion, At least a portion of the second contact is disposed in the second extension portion. Complex sensor.

19. In the manufacturing process of a composite sensor, A step of arranging electrodes on a first surface of a substrate including a first region and a second region, wherein a first electrode including a first sensing layer for measuring a first component by contacting interstitial fluid in the body is arranged in the first region, and a second electrode including a second sensing layer for measuring a second component different from the first component by contacting interstitial fluid in the body is arranged in the second region. A step of placing a counter electrode on a second side opposite to the first side of the above-mentioned substrate; A step of placing an adhesive member adjacent to the counter electrode on the second surface of the above-mentioned substrate; and A step of folding the substrate along a folding line provided between the first region and the second region; Manufacturing process of composite sensors.

20. In paragraph 19, In order to provide the appearance of the above composite sensor, further comprising a step of forming a hole in the above substrate; Manufacturing process of composite sensors.

21. In paragraph 20, The counter electrode and the adhesive member are arranged to have substantially the same height, Manufacturing process of composite sensors.

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