Multi-needle steep pulse ablation electrode device, radio frequency ablation device, method, and system

Abstract

Disclosed in the present invention are a multi-needle steep pulse ablation electrode device, a radio frequency ablation device, a method, and a system. A plurality of energy application units are configured to be inserted and slidably connected to the distal end surface of a handheld shell along a preset trajectory; a driving part is provided in the handheld shell; the driving part separately drives the energy application units to slide on the distal end surface of the handheld shell along the preset trajectory, to adjust the distance between the energy application units and the area of an energy application execution region formed by fitting of execution ends of the energy application units, so as to adapt to a preset energy application region requiring energy application on a target tumor. The problem of being difficult to accurately control the distance between needles and the ablation area present in existing steep pulse ablation electrodes is solved. After the adjustment made to adapt to the target tumor, by means of delivery or puncturing, the execution ends of the energy application units can reach the target tumor to implement energy application, so as to perform steep pulse ablation on the target tumor in the energy application execution region.

Description

Multi-needle steep pulse ablation electrode device, radiofrequency ablation device, method and system Technical Field

[0001] The present invention belongs to the technical field of medical devices, and in particular relates to a multi-needle steep pulse ablation electrode device, a radiofrequency ablation device, a method and a system. Background Art

[0002] Cancer is one of the major threats to human health and life. According to data released by the World Union Against Cancer (UICC), in 2008, the number of cancer patients worldwide reached 12.7 million, with 7.6 million deaths. Furthermore, a survey and statistical report from the Chinese Ministry of Health indicates that over the past 30 years, cancer mortality has increased by over 80%, making it the leading cause of death and health hazard for both urban and rural residents. A report from the World Health Organization (WHO) also indicates that globally, new cancer cases and cancer mortality rates are projected to increase by 1% annually, with the rate expected to be even faster in developing countries such as China, Russia, and India. By 2030, the world will see 27 million new cancer cases and 17 million deaths from cancer.

[0003] Currently, the main treatments for cancer include surgery, radiotherapy, and chemotherapy. However, these traditional treatments are limited by factors such as their indications, contraindications, and side effects, so the treatment effects are still not ideal. Therefore, seeking new cancer treatments has always been an important topic in the medical and biomedical engineering fields.

[0004] Recent studies have found that after electroporation, cells undergo irreversible electrical breakdown of the cell membrane as pulse intensity and duration increase, leading to membrane rupture and ultimately cell death. Leveraging this property, researchers have proposed irreversible electroporation therapy (IRET), a novel, non-thermal approach to tumor ablation. IREET involves applying electrical pulses to cancerous tissue, causing irreversible electrical breakdown in cancer cells, thereby destroying their survival conditions and ultimately killing them. However, currently available steep pulse ablation electrodes have several drawbacks. First, they require multiple electrodes for treatment, making it difficult to ensure parallelism or alignment of the electrodes. Second, the spacing between electrodes cannot be precisely controlled, which affects the electric field coverage and intensity distribution during treatment, thus compromising ablation effectiveness. Third, the ablation area cannot be arbitrarily adjusted based on the size or shape of the lesion. Complete ablation requires changing the puncture site or electrode type, which increases surgical complexity and time.

[0005] Summary of the Invention

[0006] To address the above problems, the present invention provides a multi-needle steep pulse ablation electrode device, a radiofrequency ablation device, a method, and a system to address the difficulty in accurately controlling the spacing between needles and the ablation area in existing steep pulse ablation electrodes. The technical solution is as follows:

[0007] A multi-needle steep pulse ablation electrode device of the present invention defines the area where energy is required to be applied to the target tissue as a preset energy application area, including:

[0008] Handheld housing;

[0009] A plurality of energy application units, wherein the connection ends of the energy application units are configured to be inserted into and slidably connected to the distal end surface of the handheld housing along a preset trajectory, and the execution ends of the plurality of energy application units are located in the same plane and cooperate to form an energy application execution area;

[0010] A driving unit is provided in the handheld housing, wherein a power input end of the driving unit extends out of the handheld housing, and a power output end of the driving unit is respectively connected to the plurality of energy application units;

[0011] The driving part is configured so that the power input end receives external power input, and the power output end outputs driving force to drive the multiple energy application units, which slide along the preset trajectories corresponding to each energy application unit to adjust the energy application execution area to match the preset energy application area.

[0012] In the multi-needle steep pulse ablation electrode device of the present invention, the preset trajectories of the multiple energy application units are configured to converge toward the center of the distal end surface of the handheld shell and / or diverge outward from the center of the distal end surface of the handheld shell.

[0013] In the multi-needle steep pulse ablation electrode device of the present invention, the shape of the energy application execution area is configured as a regular polygon.

[0014] The multi-needle steep pulse ablation electrode device of the present invention defines the direction perpendicular to the distal end surface of the handheld housing as the vertical direction, and the direction parallel to the distal end surface of the handheld housing as the horizontal direction;

[0015] The driving part includes a power input unit, a power execution unit and several connecting sliding units; the connecting sliding units are respectively connected to the corresponding energy application units, and are slidably connected to the inner cavity of the handheld shell along the preset trajectory; the output end of the power input unit extends into the inner cavity of the handheld shell, and is connected to each of the connecting sliding units through the power execution unit; the power execution unit is configured to receive the power input of the power input unit, and convert the power input into driving each of the connecting sliding units and the energy application unit to slide laterally.

[0016] In the multi-needle steep pulse ablation electrode device of the present invention, the power input unit is a vertical power input mechanism, the power execution unit includes a vertical slider and an elastic force supply unit, and the connecting sliding unit is a horizontal slider provided with a guide slope;

[0017] The input end of the vertical power input mechanism extends out of the handheld housing, and the output end of the vertical power input mechanism is connected to the vertical slider, which is used to drive the vertical slider to move vertically; the vertical slider is provided with a plurality of circumferentially arranged driving inclined surfaces, and the driving inclined surfaces are inclined toward the center of the distal end surface of the handheld housing; a plurality of transverse sliders are arranged around the circumference of the vertical slider, and the driving inclined surfaces correspond to the guide inclined surfaces one by one; the elastic force supply unit is respectively connected to each of the transverse sliders, and is used to provide an elastic force for the transverse slider to move toward the vertical slider;

[0018] Driven by the elastic force supply unit, the guide slope of each transverse slider is attached to the driving slope, and the transverse position of the transverse slider relative to the vertical slider is adjusted along the preset trajectory according to the vertical relative position change of the vertical slider.

[0019] The multi-needle steep pulse ablation electrode device of the present invention, the vertical power input mechanism includes a rotating member, an adjusting screw and a fixing nut;

[0020] The fixing nut is fixed to the vertical slider; the adjusting screw is arranged vertically, and the adjusting screw is threadedly connected to the fixing nut; the rotating member is fixed to one end of the adjusting screw and extends out of the handheld housing.

[0021] The multi-needle steep pulse ablation electrode device of the present invention, the rotating part includes a knob and a vertical elastic part; the bottom end of the knob is provided with an outward extending extension boss for abutting against the proximal end surface of the handheld shell; the two ends of the vertical elastic part are respectively connected to the extension boss and the vertical slider.

[0022] In the multi-needle steep pulse ablation electrode device of the present invention, the elastic force supply unit is an annular compression spring;

[0023] An elastic member groove is provided on one side of each transverse slider away from the center of the distal end surface of the handheld housing. The annular compression spring surrounds each transverse slider and is embedded in the corresponding elastic member groove.

[0024] The multi-needle steep pulse ablation electrode device of the present invention, the vertical slider comprises a slider body and a vertical guide structure and a plurality of oblique guide structures provided on the slider body;

[0025] The outer contour of the vertical guide structure is aligned with the inner wall of the handheld housing; the oblique guide structure includes two guide plates vertically and spaced apart on the slider body, the lower ends of the two guide plates each having an oblique cut surface facing the center of the distal end of the handheld housing, and the two corresponding oblique cut surfaces together form the driving inclined surface;

[0026] A protruding structure is provided on the upper end of the transverse sliding block, and two sides of the protruding structure are respectively provided with inclined step surfaces that cooperate to form the guiding inclined surface.

[0027] In the multi-needle steep pulse ablation electrode device of the present invention, an embedding groove is provided in the transverse sliding block and is arranged vertically and extends to the protruding structure.

[0028] In the multi-needle steep pulse ablation electrode device of the present invention, the lower end of the transverse slider is provided with an extension slide extending toward at least one side of the preset track;

[0029] The distal surface of the handheld shell is a distal bottom plate structure, which includes a chassis and a cover plate; the chassis is respectively provided with guide grooves corresponding to each of the preset trajectories, and the width of the guide grooves matches the overall size of the extension slide; the bottom surface of the guide groove is provided with a long strip through groove for the energy application unit to pass through; the cover plate is arranged on the chassis and is provided with guide openings corresponding one-to-one to the guide grooves, and the width of the guide openings matches the width of the transverse slider.

[0030] In the multi-needle steep pulse ablation electrode device of the present invention, the base plate and the cover plate are respectively provided with insertion openings for inserting the vertical slider.

[0031] In the multi-needle steep pulse ablation electrode device of the present invention, the power input unit is a rotating member, the power execution unit is a plurality of intermediate transmission members, and the connecting sliding unit is a transverse slider;

[0032] The first ends of the plurality of intermediate transmission members are respectively rotatably connected to the rotating member and offset from the rotation axis of the rotating member, and at least part of the rotating member extends out of the handheld housing; the second ends of the intermediate transmission members are rotatably connected to the transverse slider;

[0033] The distal end surface of the handheld shell is a chassis, and the chassis is provided with a plurality of long strip through slots for the energy application unit to pass through, and the trajectory of the long strip through slots is the preset trajectory; the transverse slider slides on the chassis, and the energy application unit is clamped on the transverse slider and extends out of the corresponding long strip through slots.

[0034] In the multi-needle steep pulse ablation electrode device of the present invention, the power input unit is a vertical power input mechanism, the power execution unit is a plurality of oblique connecting rods, and the connecting sliding unit is a transverse sliding block;

[0035] The input end of the vertical power input mechanism extends out of the handheld housing, and the output end of the vertical power input mechanism is respectively connected to the first end of each of the oblique connecting rods for rotation and / or swinging, so as to drive the first end of the oblique connecting rod to perform vertical movement; the second end of the oblique connecting rod is respectively connected to the corresponding transverse slider for rotation and / or swinging;

[0036] The distal end surface of the handheld shell is a chassis, and the chassis is provided with a plurality of long strip through slots for the energy application unit to pass through, and the trajectory of the long strip through slots is the preset trajectory; the transverse slider slides on the chassis, and the energy application unit is clamped on the transverse slider and extends out of the corresponding long strip through slots.

[0037] The multi-needle steep pulse ablation electrode device of the present invention, the power execution unit also includes a support link, the first end of the support link is rotatably and / or swingably connected to the handheld shell, and the second end of the support link is rotatably and / or swingably connected to the rod body of the oblique link.

[0038] The multi-needle steep pulse ablation electrode device of the present invention, the vertical power input mechanism includes a rotating member, an adjusting screw, a connecting slider and a vertical elastic member;

[0039] The adjusting screw is vertically arranged in the handheld housing, and the adjusting screw is threadedly connected to the proximal end surface of the handheld housing. The connecting slider is rotatably connected to the adjusting screw, and the connecting slider is respectively connected to the first end of each of the oblique connecting rods; the rotating member is fixed to one end of the adjusting screw and extends out of the handheld housing; the two ends of the vertical elastic member are respectively connected to the handheld housing and the connecting slider.

[0040] In the multi-needle steep pulse ablation electrode device of the present invention, the energy applying unit is a metal puncture needle.

[0041] In the multi-needle steep pulse ablation electrode device of the present invention, the number of the energy applying units is three, four or five.

[0042] A method of using a multi-needle steep pulse ablation electrode device of the present invention for ablating target tissue comprises:

[0043] A multi-needle steep pulse ablation electrode device is provided: the device further comprises a handheld housing, a plurality of energy application units and a driving portion; the connection ends of the plurality of energy application units are configured to be inserted into and slidably connected to the distal end surface of the handheld housing along a preset trajectory, the execution ends of the plurality of energy application units are located in the same plane, and cooperate to form an energy application execution area; the driving portion is disposed in the handheld housing, and the power input end of the driving portion extends out of the handheld housing, and the power output end of the driving portion is respectively connected to the plurality of energy application units; the driving portion is configured such that the power input end receives external power input, and the power output end outputs a driving force to drive the plurality of energy application units to slide respectively along their corresponding preset trajectories;

[0044] The driving portion is configured to receive external power input to drive each of the energy application units to slide along its preset trajectory to obtain the energy application execution area that matches the preset energy application area;

[0045] The multi-needle steep pulse ablation electrode device is configured so that each of the energy application units delivers or punctures the target position corresponding to the target tissue;

[0046] Each of the energy application units is configured to deliver energy to target tissue.

[0047] A tumor ablation device according to the present invention comprises:

[0048] A carrier carrying a plurality of treatment units; wherein the connection ends of the plurality of treatment units are configured to be inserted into and slidably connected to the distal end surface of the carrier along a preset trajectory, and the execution ends of the treatment units are located in the same plane and cooperate to form an energy application execution area;

[0049] A driving unit is disposed in the carrier, and a power output end of the driving unit is connected to each of the treatment units respectively; the driving unit is configured to drive each of the treatment units to slide along its corresponding preset trajectory to adjust the energy application execution area to match the preset tumor ablation area.

[0050] A minimally invasive medical system of the present invention comprises any one of the multi-needle steep pulse ablation electrode devices described above.

[0051] Due to the adoption of the above technical solution, the present invention has the following advantages and positive effects compared with the prior art:

[0052] In one embodiment of the present invention, multiple energy application units are configured to be inserted and slidably connected to the distal end of a handheld housing along a preset trajectory. A drive unit is disposed within the handheld housing, which drives each energy application unit to slide along the preset trajectory on the distal end of the handheld housing, thereby adjusting the spacing between the energy application units and the area of ​​the energy application execution region formed by the execution end of each energy application unit to adapt to the preset energy application region required for energy application to the target tumor. This solves the problem of the difficulty in accurately controlling the spacing between the needles and the ablation area in existing steep pulse ablation electrodes. After adjustment to adapt to the target tumor, the execution end of the energy application unit can be delivered or inserted to the target tumor for energy application, thereby performing steep pulse ablation on the target tumor within the energy application execution region. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] FIG1 is a schematic diagram of a multi-needle steep pulse ablation electrode device excluding a handheld housing according to a first embodiment of the present invention;

[0054] FIG2 is a cross-sectional view of a multi-needle steep pulse ablation electrode device according to a first embodiment of the present invention;

[0055] FIG3 is a schematic diagram of a multi-needle steep pulse ablation electrode device according to a first embodiment of the present invention;

[0056] FIG4 is a schematic diagram of a chassis of a multi-needle steep pulse ablation electrode device according to a first embodiment of the present invention;

[0057] FIG5 is a schematic diagram of a cover plate of a multi-needle steep pulse ablation electrode device according to a first embodiment of the present invention;

[0058] FIG6 is a schematic diagram of a transverse slider of a multi-needle steep pulse ablation electrode device according to a first embodiment of the present invention;

[0059] FIG7 is a cross-sectional view of a transverse slider of the multi-needle steep pulse ablation electrode device according to the first embodiment of the present invention;

[0060] FIG8 is a schematic diagram of a vertical slider of a multi-needle steep pulse ablation electrode device according to a first embodiment of the present invention;

[0061] FIG9 is a cross-sectional view of a vertical slider of the multi-needle steep pulse ablation electrode device according to the first embodiment of the present invention;

[0062] FIG10 is a schematic diagram of the cooperation between the vertical slider and the horizontal slider of the multi-needle steep pulse ablation electrode device according to the first embodiment of the present invention;

[0063] FIG11 is a cross-sectional view of the cooperation between the vertical slider and the horizontal slider of the multi-needle steep pulse ablation electrode device according to the first embodiment of the present invention;

[0064] FIG12 is a schematic diagram of a knob of a multi-needle steep pulse ablation electrode device according to a first embodiment of the present invention;

[0065] FIG13 is a cross-sectional view of a knob of a multi-needle steep pulse ablation electrode device according to a first embodiment of the present invention;

[0066] FIG14 is a front view of the multi-needle steep pulse ablation electrode device excluding the handheld housing according to the second embodiment of the present invention;

[0067] FIG15 is a schematic diagram of a multi-needle steep pulse ablation electrode device excluding the handheld housing according to the second embodiment of the present invention;

[0068] FIG16 is a cross-sectional view of a multi-needle steep pulse ablation electrode device according to a third embodiment of the present invention;

[0069] FIG17 is a schematic diagram of the multi-needle steep pulse ablation electrode device excluding the handheld housing according to the third embodiment of the present invention.

[0070] Explanation of the reference numerals: 1: energy application unit; 2: chassis; 201: guide groove; 202: long strip groove; 3: cover plate; 301: guide opening; 4: annular compression spring; 5: horizontal slider; 501: guide slope; 502: embedded through groove; 503: elastic member groove; 6: vertical slider; 601: guide plate; 602: guide spacer; 603: blind hole; 604: through hole; 7: vertical elastic member; 8: knob; 801: knob threaded hole; 802: semicircular long strip groove; 803: extension boss; 9: adjusting screw; 10: fixing nut; 11: handheld shell; 12: rotating shaft; 13: intermediate transmission member; 14: connecting slider; 15: oblique connecting rod; 16: supporting connecting rod. DETAILED DESCRIPTION

[0071] The following describes the embodiments of the present invention through specific examples. Those skilled in the art can easily understand other advantages and functions of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention. It should be understood that the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation. Therefore, they should not be understood as limiting the present invention. In addition, the terms "first", "second", etc. are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of the technical features indicated. Therefore, features specified as "first", "second", etc. may explicitly or implicitly include one or more of such features. In the description of the present invention, unless otherwise specified, "multiple" means two or more.

[0072] It should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood broadly. For example, they may refer to fixed, detachable, or integral connections; mechanical or electrical connections; direct or indirect connections through an intermediary; and internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0073] In addition, in the description of this application, the "proximal end" and "distal end" are commonly used terms in the medical field. Specifically, the "proximal end" refers to the end closest to the operator, the "proximal surface" refers to the end surface closest to the operator, the "distal end" refers to the end farther from the operator, and the "distal surface" refers to the end surface farther from the operator.

[0074] Example 1

[0075] 1 to 13 , in one embodiment, a multi-needle steep pulse ablation electrode device defines the area where energy is required to be applied to the target tissue as a preset energy application area, and includes a handheld housing 11 , a plurality of energy application units 1 and a driving portion.

[0076] The connection ends of the multiple energy application units 1 are configured to be inserted and slidably connected to the distal end surface of the handheld shell 11 along a preset trajectory. The execution ends of the multiple energy application units 1 are located in the same plane and cooperate to form an energy application execution area.

[0077] The drive unit is housed within the handheld housing 11, with its power input extending from the housing 11 and its power output connected to each of the multiple energy application units 1. The drive unit is configured to receive external power input at its power input and output driving force from its power output to drive the multiple energy application units 1, causing them to slide along their corresponding preset trajectories, thereby adjusting the energy application execution area to match the preset energy application area.

[0078] In this embodiment, multiple energy application units 1 are configured to be inserted and connected to the distal end of the handheld shell 11 by sliding along a preset trajectory. A driving unit is provided in the handheld shell 11, and the driving unit drives each energy application unit 1 to slide along the preset trajectory on the distal end of the handheld shell 11, thereby adjusting the spacing between each energy application unit 1 and the area of ​​the energy application execution area formed by the execution end of each energy application unit 1, so as to adapt to the preset energy application area where energy is required to be applied to the target tumor, thereby solving the problem of the existing steep pulse ablation electrode that is difficult to accurately control the spacing between each needle and the ablation area. After adjusting to adapt to the target tumor, the execution end of the energy application unit 1 can be delivered or inserted to the target tumor to apply energy, so as to perform steep pulse ablation on the target tumor in the energy application execution area.

[0079] The specific structure of the multi-needle steep pulse ablation electrode device of this embodiment is further described below:

[0080] In this embodiment, the preset trajectories of the aforementioned multiple energy application units 1 are configured to converge toward or diverge outward from the center of the distal end face of the handheld housing 11. Specifically, the preset trajectories can be configured as straight lines, specifically, elongated through slots 202 defined along rays radiating outward from the center point of the distal end face of the handheld housing 11, with the rays on which the preset trajectories lie arranged at equal angles. Of course, in other embodiments, the preset trajectories can also be configured as curves or other forms, such as curves that deflect toward the center point of the distal end face, without specific limitation herein.

[0081] In this embodiment, the energy application area can be configured as a regular polygon. Specifically, the number of energy application units 1 is equal to the number of endpoints of the regular polygon, with adjacent energy application units 1 equidistant from each other and centered around the center point of the distal end face. The number of energy application units 1 can be three, four, five, or more, depending on specific needs.

[0082] The direction perpendicular to the distal end surface of the handheld housing 11 is defined as the vertical direction, and the direction parallel to the distal end surface of the handheld housing 11 is defined as the horizontal direction.

[0083] In this embodiment, the driving part may specifically include a power input unit, a power execution unit and a plurality of connecting sliding units. The connecting sliding units are respectively connected to the corresponding energy application units 1, and are connected to the inner cavity of the handheld shell 11 by sliding along a preset trajectory. The output end of the power input unit extends into the inner cavity of the handheld shell 11, and is connected to each connecting sliding unit through the power execution unit. The power execution unit is configured to receive the power input of the power input unit, and convert the power input into driving each connecting sliding unit and the energy application unit 1 to slide laterally. Among them, the power input unit is a component for receiving external power input, the power execution unit is a power conversion mechanism that converts the input power into a power driving the connecting sliding unit to slide on the distal surface, and the connecting sliding unit is a component that connects the energy application unit 1 and realizes sliding.

[0084] 6 to 11 , further, the power input unit of this embodiment may be a vertical power input mechanism, the power execution unit includes a vertical slider 6 and an elastic force supply unit, and the connecting sliding unit may be a horizontal slider 5 provided with a guide slope 501 .

[0085] The input end of the vertical power input mechanism extends out of the handheld housing 11, and the output end of the vertical power input mechanism is connected to the vertical slider 6 for outputting a vertical driving force and driving the vertical slider 6 to perform vertical movement. Several transverse sliders 5 are arranged to be evenly distributed around the circumference of the vertical slider 6, and the driving inclined surface corresponds one-to-one with the guide inclined surface 501. The guide inclined surface 501 is an inclined surface that is inclined toward the center of the distal surface and tilted downward (the direction of the proximal surface of the handheld housing 11 toward the distal surface is downward). The vertical slider 6 is provided with several driving inclined surfaces arranged around it, corresponding one-to-one with the transverse slider 5, and the driving inclined surface is parallel to the guide inclined surface 501 (i.e., it is also an inclined surface that is inclined toward the center of the distal surface of the handheld housing 11 and tilted downward). An elastic force supply unit is connected to each transverse slider 5 respectively, for providing an elastic force to push the transverse slider 5 toward the vertical slider 6, i.e., the direction of the elastic force is toward the center of the distal surface of the handheld housing 11.

[0086] Driven by the elastic force supply unit, the guide bevel 501 of each transverse slider 5 is aligned with the drive bevel, and the lateral position of the transverse slider 5 relative to the vertical slider 6 is adjusted along a predetermined trajectory based on the vertical relative position change of the vertical slider 6. The downward movement of the vertical slider 6 pushes each transverse slider 5 outward, causing it to move along the predetermined trajectory away from the center of the distal end of the handheld housing 11. The upward movement of the vertical slider 6 releases the lateral restraints on the transverse slider 5. Under the elastic force of the elastic force supply unit, each transverse slider 5 moves along the predetermined trajectory toward the center of the distal end of the handheld housing 11 until it is aligned with the vertical slider 6.

[0087] Specifically, the vertical power input mechanism may include a rotating member, an adjusting screw 9 and a fixing nut 10. The adjusting screw 9 is arranged vertically and rotatably connected to the inner cavity of the handheld shell 11, and the adjusting screw 9 fixes the nut 10. The rotating member is fixed to one end of the adjusting screw 9 close to the proximal end surface of the handheld shell 11 and extends out of the handheld shell 11. The fixing nut 10 is threadedly connected to the adjusting screw 9, and the fixing nut 10 is fixed on the vertical slider 6. Specifically, a blind hole 603 can be opened on the proximal end surface (upper end surface) of the vertical slider 6, and the fixing nut 10 can be fixedly set in the blind hole 603, and a through hole 604 can be set on the bottom surface of the blind hole 603 for the adjusting screw 9 to pass through.

[0088] Referring to Figures 12 and 13, in this embodiment, the rotating member includes a knob 8 and a vertical elastic member 7. The bottom center of the knob 8 has a threaded hole for the knob 8, which forms a threaded fit with the adjustment screw 9. When the knob 8 is rotated, the adjustment screw 9 also rotates. The outer surface of the knob 8 can be provided with a number of evenly arranged semicircular elongated grooves 802, which primarily serve as a slip-resistant function. Furthermore, the bottom end of the knob 8 is provided with an outwardly extending extension boss 803, which is used to abut the proximal end surface of the handheld housing 11 (i.e., the proximal end surface of the handheld housing 11 is provided with an opening that allows the knob 8 to extend but does not allow the extension boss 803 to extend). The two ends of the vertical elastic member 7 are respectively connected to the extension boss 803 and the vertical slider 6, which are used to maintain the knob 8 at all times abutting the proximal end surface of the handheld housing 11. The vertical elastic member 7 can specifically be a compression spring.

[0089] When the knob 8 is rotated, the adjusting screw 9 is driven to rotate, and the fixing nut 10 threadedly connected to it is fixed on the vertical slider 6 and will not rotate. Under the action of the thread, the fixing nut 10 will move in the vertical direction, thereby driving the vertical slider 6 to move up and down.

[0090] Furthermore, the elastic force supply unit can be specifically an annular compression spring 4. Accordingly, each transverse slider 5 has an elastic member groove 503 defined on a side facing away from the center of the distal end surface of the handheld housing 11. The annular compression spring 4 surrounds each transverse slider 5 and is embedded in the corresponding elastic member groove 503. The annular compression spring 4 provides the elastic force required by the transverse slider 5 through its annular inward contraction force.

[0091] In this embodiment, the vertical slider 6 specifically includes a slider body and a vertical guide structure and a plurality of oblique guide structures provided on the slider body. The outer contour of the vertical guide structure fits the inner cavity wall of the handheld shell 11. The inner cavity of the handheld shell 11 can be a cylindrical cavity, and the outer contour (outer ring surface) of the vertical guide structure can be a circle that matches the cylindrical side surface of the cylindrical cavity. The oblique guide structure can specifically include two guide plates 601 vertically and spaced apart on the slider body. The lower ends of the two guide plates 601 are each provided with an oblique section facing the center of the distal end surface of the handheld shell 11. The two corresponding oblique sections together form a driving inclined surface.

[0092] The upper end of the transverse slider 5 is provided with a corresponding raised structure, and on either side of the raised structure are inclined stepped surfaces that cooperate to form the guide ramp 501. That is, when the guide ramp 501 is in contact with the driving ramp, the raised structure always extends into the guide gap 602 formed between the two guide plates 601, guiding the relative movement between the transverse slider 5 and the vertical slider 6.

[0093] Furthermore, in order to ensure sufficient clamping of the energy application unit 1, a vertically arranged embedded groove 502 extending to the raised structure is provided in the horizontal slider 5, that is, the connecting end of the energy application unit 1 can be inserted into and extended from the embedded groove 502, thereby ensuring a longer clamping length and achieving the purpose of stable clamping.

[0094] In this embodiment, in order to guide the transverse slider 5 along the preset trajectory, the lower end of the transverse slider 5 may be provided with an extension slide extending toward at least one side of the preset trajectory, which may actually be two extension slides extending toward both sides of the predicted trajectory (not the two ends of the trajectory).

[0095] 4 and 5 , the distal end surface of the handheld housing 11 may be a distal bottom plate structure, which includes a chassis 2 and a cover plate 3, which may be threadedly connected. The chassis 2 is provided with guide grooves 201 corresponding to each preset trajectory, and the width of the guide grooves 201 matches the overall size of the extension slide. The bottom surface of the guide grooves 201 is provided with the above-mentioned long strip through grooves 202 for the energy application unit 1 to pass through. The cover plate 3 is covered on the chassis 2 and is provided with guide openings 301 corresponding to the guide grooves 201 one by one, and the width of the guide openings 301 matches the width of the transverse slider 5. That is, the chassis 2 and the cover plate 3 cooperate to form a sliding chamber that is adapted to the transverse slider 5 and the extension slides on both sides thereof.

[0096] Furthermore, since the vertical slider 6 of this embodiment slides up and down, it may interfere with the chassis 2 and the cover 3 in some scenarios. Therefore, the chassis 2 and the cover 3 are respectively provided with insertion openings for the vertical slider 6 to extend therein for avoidance.

[0097] In this embodiment, the energy application unit 1 can be specifically a metal puncture needle, and multiple metal puncture needles are electrically connected to the high-voltage pulse power supply respectively, wherein at least one metal puncture needle is an input electrode (used to introduce high-frequency, high-voltage pulse current into the energy application execution area), and at least one metal puncture needle is a recovery electrode (used to extract high-frequency, high-voltage pulse current).

[0098] The specific technical means of this embodiment are described below:

[0099] The multi-needle steep pulse ablation electrode device of this embodiment solves the problem that high-voltage steep pulse treatment technology cannot accurately control the spacing between needles and arbitrarily adjust the ablation area during tumor ablation surgery. At the same time, it also solves the problem that other normal tissues may be damaged when surgically removing tumors.

[0100] 1. The multi-needle steep pulse ablation electrode device of this embodiment makes the metal puncture needles parallel to each other and the movement trajectories of each metal puncture needle are in the same plane through the cooperation of the transverse slider 5 with the guide groove 201 of the chassis 2 and the upper cover plate 3, and the structure of the embedded through groove 502 of the transverse slider 5 for fixing the tail end of the metal puncture needle is perpendicular to the chassis 2, so that the metal puncture needles are parallel to each other and the movement trajectories of each metal puncture needle are in the same plane, ensuring that multiple metal puncture needles can simultaneously penetrate the same lesion tissue and be parallel to each other, solving the problem that medical staff need to hold or limit devices to keep the needles parallel to each other during steep pulse ablation surgery. The electrode device itself can make the needles parallel to each other, avoiding the need for other limiting devices or medical staff to hold electrodes to ensure the parallelism of the needles during treatment, thereby reducing the difficulty of surgical operation.

[0101] 2. The multi-needle steep pulse ablation electrode device of this embodiment can precisely control the distance between each needle through the threaded connection structure between the adjustment screw 9, the knob 8, and the fixing nut 10, as well as the cooperation between the fixing nut 10 and the blind hole 603 of the vertical slider 6, and the cooperation between the guide bevel 501 and the driving bevel. Because each time the knob 8 is rotated one thread, the adjustment screw 9 rotates one thread, and the vertical slider 6 moves one pitch up or down, which in turn pushes the transverse slider 5 to move a certain distance. Therefore, this threaded connection structure and the cooperation between the transverse slider 5 and the vertical slider 6 can achieve precise control of the spacing between each needle. This solves the problem that high-voltage steep pulse therapy technology, during surgical ablation, selects the space between two electrodes to apply high-voltage pulses for tumor ablation. The electrode spacing affects the range of the electric field covering the tumor and the field strength distribution during treatment, thereby affecting the ablation effect. Precisely controlling the distance between the electrodes can precisely control the range of the electric field covering the tumor and the field strength distribution, achieving a complete ablation effect without damaging other normal tissues.

[0102] 3. The electrode of the present invention can arbitrarily adjust the ablation area of ​​the electrode through the cooperation of the guiding bevel 501 and the driving bevel, as well as the cooperation of the elastic groove 503 of the horizontal slider 5 and the annular compression spring 4. When the vertical slider 6 moves downward, it will push the horizontal slider 2 to move outward from the center of the chassis 2, and the ablation area of ​​the electrode will increase; when the vertical slider 6 moves upward, the annular compression spring 4 will tighten, so that the guiding bevel 501 of the horizontal slider 5 always cooperates with the driving bevel of the vertical slider 6, and at the same time, the horizontal slider 5 moves toward the center of the chassis 2, and the ablation area of ​​the electrode device is reduced. In this way, the ablation area of ​​the electrode can be arbitrarily adjusted, solving the problem that during tumor ablation, the electrode itself cannot change the ablation area according to the size and shape of the tumor, and the ablation area can only be changed by replacing electrodes of different specifications or puncture positions, thereby completely ablating the tumor. This reduces the difficulty of the operation and improves the flexibility of the electrode in clinical application. In this way, during treatment, the ablation area of ​​the electrode can be changed according to the size and shape of the tumor. There is no need to replace electrodes of different specifications or change the puncture position to achieve complete ablation effect, which simplifies the surgical operation and saves surgical time.

[0103] The spacing between the needles is controlled by the thread structure. Each rotation of the thread changes the spacing between the needles, allowing precise control of the spacing between the needles. This prevents the ablation effect from being compromised by the inability to precisely control the electrode spacing, which affects the tumor coverage and field strength distribution during treatment.

[0104] 4. The electrode of the present invention ablates the lesion tissue by combining surgery and high-voltage steep pulse ablation technology, which not only solves the problem of damaging other normal tissues when surgically removing the lesion tissue, but also solves the problem of it being difficult to accurately locate the lesion tissue when treating the lesion tissue with high-voltage steep pulse ablation technology, making it impossible to completely ablate the lesion tissue, thereby enhancing the therapeutic effect of the surgery.

[0105] Example 2

[0106] 14 and 15 , this embodiment provides a multi-needle steep pulse ablation electrode device based on the above-mentioned embodiment 1, and adjusts the arrangement of the driving part, as follows:

[0107] In this embodiment, the power input unit may be a rotating member, the power execution unit may be a plurality of intermediate transmission members 13 , and the connecting sliding unit may be a transverse slider 5 .

[0108] The first ends of the intermediate transmission members 13 are rotatably connected to the rotating member (the rotation axis is oriented vertically, specifically by the rotating shaft 12), and are offset from the rotation axis of the rotating member, with at least some of the rotating members extending out of the handheld housing 11. The second ends of the intermediate transmission members 13 are rotatably connected to the transverse slider 5 (also, the rotation axis is oriented vertically, specifically by the rotating shaft 12).

[0109] The distal end of the handheld housing 11 forms a chassis 2, which is provided with a plurality of elongated slots 202 for the energy application unit 1 to pass through. These slots 202 follow a predetermined trajectory. A transverse slider 5 slides on the chassis 2, with the energy application unit 1 clamped by the slider 5 and extending out of the corresponding elongated slot 202. Of course, the distal end arrangement can also be a combination of the chassis 2 and cover 3 described in the first embodiment.

[0110] When there are four energy application units 1, the preset trajectory can be four elongated slots 202 arranged at 90° on the chassis 2. The transverse slider 5 is connected to the intermediate transmission member 13, and the intermediate transmission member 13 is connected to the rotating member (i.e., the knob 8) via a rotating shaft 12, and they can rotate relative to each other. The transverse slider 5 contains a circular slot for securing the energy application unit 1. When the knob 8 is turned, the intermediate transmission member 13 rotates and moves accordingly. The movement of the intermediate transmission member 13 causes the transverse slider 5 to rotate and move. Because the energy application unit 1 is fixed to the transverse slider 5, the energy application unit 1 also moves, but the movement path of the energy application unit 1 is limited by the needle track (elongated slot 202) on the chassis 2. When the energy application unit 1 moves, the spacing between the energy application units 1 changes, thereby changing the ablation area. Because the movement of the energy application units 1 occurs within the same plane and the energy application units 1 are initially parallel to each other, the actuator ends of each energy application unit 1 always remain in the same plane.

[0111] Example 3

[0112] 16 and 17 , this embodiment also provides a multi-needle steep pulse ablation electrode device based on the above-mentioned embodiment 1, and adjusts the arrangement of the driving part, as follows:

[0113] In this embodiment, the power input unit is a vertical power input mechanism, the power execution unit is a plurality of oblique connecting rods 15 , and the connecting sliding unit is a transverse sliding block 5 .

[0114] The input end of the vertical power input mechanism extends from the handheld housing 11. The output end of the vertical power input mechanism is rotationally and / or swingably connected to the first end of each oblique link 15, thereby driving the first end of the oblique link 15 to perform vertical movement. The second end of the oblique link 15 is rotationally and / or swingably connected to the corresponding transverse slider 5 (if the preset trajectory is a straight line, only rotation is required).

[0115] Similar to the second embodiment, the distal end of the handheld housing 11 forms a chassis 2, which is provided with a plurality of elongated slots 202 for the energy application unit 1 to pass through. The slots 202 follow a predetermined trajectory. A transverse slider 5 slides on the chassis 2, with the energy application unit 1 clamped by the slider 5 and extending out of the corresponding elongated slot 202. Of course, the distal end arrangement can also be a combination of the chassis 2 and cover 3 described in the first embodiment.

[0116] Furthermore, in order to ensure the stability of the movement of the diagonal link, the power execution unit also includes a support link 16, the first end of the support link 16 is rotatably and / or swingably connected to the handheld shell 11, and the second end of the support link 16 is rotatably and / or swingably connected to the rod body of the diagonal link 15 (specifically, it can be the midpoint or other position of the diagonal link 15).

[0117] Specifically, the vertical power input mechanism may include a rotating member, an adjusting screw 9, a connecting slider 14 and a vertical elastic member 7; the adjusting screw 9 is vertically arranged in the handheld shell 11, and the adjusting screw 9 is threadedly connected to the proximal end surface of the handheld shell 11, the connecting slider 14 is rotatably connected to the adjusting screw 9, and the connecting slider 14 is respectively connected to the first end of each oblique connecting rod 15; the rotating member is fixed to one end of the adjusting screw 9 and extends out of the handheld shell 11; the two ends of the vertical elastic member 7 are respectively connected to the handheld shell 11 and the connecting slider 14.

[0118] When there are four energy application units 1, the preset trajectory can be four long strip-shaped through slots 202 arranged at 90 degrees on the chassis 2. A cylinder with a threaded hole can be set in the center of the chassis 2 for the movement of the adjusting screw 9 on the rotating part (knob 8). There is a circular through hole in the transverse slider 5 for fixing the energy application unit 1. The transverse slider 5 is connected to the diagonal connecting rod 15, the diagonal connecting rod 15 and the supporting connecting rod 16, and the diagonal connecting rod 15 and the connecting slider 14 by a piston pin, and they can rotate with each other. The adjusting screw 9 is provided at the bottom center of the knob 8, forming a threaded fit with the chassis 2. When the knob 8 is turned, the knob 8 will move downward, thereby causing the connecting slider 14 to move downward. The movement of the connecting slider 14 will drive the rotation of the diagonal connecting rod 15 and the supporting connecting rod 16, and the rotation of the diagonal connecting rod 15 will cause the transverse slider 5 to move, and the energy application unit 1 will also move. When the energy application units 1 move, the spacing between them changes, and thus the ablation area changes. Because the movement of the energy application units 1 occurs within the same plane and the energy application units 1 are initially parallel to each other, the actuating ends of the energy application units 1 always lie within the same plane.

[0119] Example 4

[0120] This embodiment, based on the above-mentioned embodiments 1 to 3, provides a method for ablating tumor tissue using a multi-needle steep pulse ablation electrode device, including:

[0121] The first step is to provide a multi-needle steep pulse ablation electrode device: it further comprises a handheld shell 11, a plurality of energy application units 1 and a driving part. The connection ends of the plurality of energy application units 1 are configured to be inserted and connected to the distal end surface of the handheld shell 11 by sliding along a preset trajectory. The execution ends of the plurality of energy application units 1 are located in the same plane and cooperate to form an energy application execution area. The driving part is arranged in the handheld shell 11, and the power input end of the driving part extends out of the handheld shell 11, and the power output end of the driving part is respectively connected to the plurality of energy application units 1. The driving part is configured to receive external power input at the power input end, and output driving force from the power output end to drive the plurality of energy application units 1 to slide along their corresponding preset trajectories.

[0122] In the second step, the driving unit is configured to drive each metal puncture needle to slide along its preset trajectory by rotating the knob 8 to obtain an energy application execution area that matches the preset energy application area of ​​the corresponding tumor tissue.

[0123] In the third step, the multi-needle steep pulse ablation electrode device is configured so that each energy application unit 1 delivers or punctures the target position corresponding to the target tissue.

[0124] Each energy application unit 1 is configured to deliver energy to target tissue.

[0125] The method of this embodiment can be applied to in vitro experiments using a multi-needle steep pulse ablation electrode device to detect the accuracy of the energy application execution area formed by the device.

[0126] Example 5

[0127] This embodiment provides a radiofrequency ablation device based on the above-mentioned embodiment 1, defines the area where energy is required to be applied to the target tissue as a preset radiofrequency ablation area, and includes a handheld housing 11, multiple energy application units 1 and a driving part.

[0128] The connection ends of the energy application units 1 are configured to be inserted and slidably connected to the distal end surface of the handheld shell 11 along a preset trajectory. The execution ends of multiple energy application units 1 are located in the same plane and cooperate to form a radiofrequency ablation execution area.

[0129] The drive unit is housed within the handheld housing 11, with its power input extending from the housing 11 and its power output connected to each of the multiple energy application units 1. The drive unit is configured to receive external power input at its power input and output driving force from its power output to drive the multiple energy application units 1, each sliding along a corresponding preset trajectory to adjust the RF ablation execution area to match the preset RF ablation area.

[0130] In this embodiment, multiple energy application units 1 are configured to be inserted and connected to the distal end of the handheld shell 11 by sliding along a preset trajectory. A driving unit is provided in the handheld shell 11, and the driving unit drives each energy application unit 1 to slide along the preset trajectory on the distal end of the handheld shell 11, thereby adjusting the spacing between each energy application unit 1 and the area of ​​the radiofrequency ablation execution area formed by the execution end of each energy application unit 1, so as to adapt to the preset radiofrequency ablation area where energy needs to be applied to the target tumor, thereby solving the problem of the existing steep pulse ablation electrode that is difficult to accurately control the spacing between each needle and the ablation area. After adjusting to adapt to the target tumor, the execution end of the energy application unit 1 can be delivered or inserted to reach the target tumor to apply energy, so as to perform radiofrequency ablation on the target tumor in the radiofrequency ablation execution area.

[0131] This embodiment differs from the first embodiment described above in that the energy application unit 1 of this embodiment is used for radiofrequency ablation, specifically a radiofrequency ablation needle. When the radiofrequency current in the radiofrequency ablation needle flows through human tissue, the rapid changes in the electromagnetic field cause polarized water molecules in the tissue to move at high speed, generating heat (i.e., endogenous heating effect). This causes water inside and outside the cells to evaporate, dry out, shrink, and fall off, resulting in aseptic necrosis, thereby achieving the therapeutic purpose.

[0132] Example 6

[0133] This embodiment provides a tumor ablation device, including a carrier carrying a plurality of treatment units and a driving unit.

[0134] The connection ends of the treatment units are configured to be inserted and slidably connected to the distal surface of the carrier along a predetermined trajectory. The actuating ends of the treatment units are located in the same plane and together form an energy application execution area. A driver unit is disposed within the carrier, and its power output end is connected to each treatment unit. The driver unit is configured to drive each treatment unit to slide along its corresponding predetermined trajectory, thereby adjusting the energy application execution area to match the predetermined tumor ablation area.

[0135] Example 7

[0136] This embodiment provides a medical minimally invasive system based on the above-mentioned embodiments one to four. The medical minimally invasive system configures multiple energy application units 1 to be inserted and slidably connected to the distal end surface of the handheld shell 11 along a preset trajectory. A driving part is set in the handheld shell 11, and the driving part drives each energy application unit 1 to slide along the preset trajectory on the distal end surface of the handheld shell 11, thereby adjusting the spacing between each energy application unit 1 and the area of ​​the energy application execution area formed by the execution end of each energy application unit 1 to adapt to the preset energy application area where the target tumor needs to apply energy, solving the problem of the existing steep pulse ablation electrode that it is difficult to accurately control the spacing between each needle and the ablation area. After adjusting to adapt to the target tumor, the execution end of the energy application unit 1 can be delivered or inserted to reach the target tumor to apply energy, so as to ablate the target tumor in the energy application execution area.

[0137] Application Examples

[0138] This application example illustrates the specific application based on the above-mentioned embodiments one to four: first, by rotating the knob 8, the spacing between each metal puncture needle and the ablation area are matched to the corresponding tumor target, and the metal puncture needle is inserted into the patient's diseased part by holding it in the handheld part, and then the high-voltage pulse power supply is turned on. The high-frequency, high-voltage pulse current output by it is introduced into the patient's diseased part through one or more of the metal puncture needles, and the remaining metal puncture needles serve as loop electrodes to introduce the high-frequency, high-voltage pulse current into the input end of the high-voltage pulse power supply. When the high-frequency, high-voltage pulse current passes through the patient's diseased cells, the high-frequency, high-voltage pulse current will destroy the cell membrane of the diseased cells, thereby killing the diseased cells. Since the metal puncture needles are used as loop electrodes, the high-frequency, high-voltage pulse current only passes through the diseased part and will not damage healthy cells outside the diseased tissue.

[0139] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and their equivalents, they still fall within the scope of protection of the present invention.

Claims

1. A multi-needle steep pulse ablation electrode device, characterized in that: The area where the target tissue needs to be energy applied is defined as the preset energy application area, including: Handheld housing; A plurality of energy application units, wherein the connection ends of the energy application units are configured to be inserted into and slidably connected to the distal end surface of the handheld housing along a preset trajectory, and the execution ends of the plurality of energy application units are located in the same plane and cooperate to form an energy application execution area; A driving unit is disposed in the handheld housing, and a power input end of the driving unit extends out of the handheld housing, and a power output end of the driving unit is respectively connected to a plurality of the energy application units; The driving part is configured so that the power input end receives external power input, and the power output end outputs driving force to drive the plurality of energy application units, which slide along the preset trajectories corresponding to the respective energy application units, so as to adjust the energy application execution area to match the preset energy application area.

2. The multi-needle steep pulse ablation electrode device according to claim 1, characterized in that: The preset trajectories of the plurality of energy application units are configured to converge toward the center of the distal end surface of the handheld shell and / or diverge outward from the center of the distal end surface of the handheld shell, and the shape of the energy application execution area is configured as a regular polygon.

3. The multi-needle steep pulse ablation electrode device according to claim 1, characterized in that: The direction perpendicular to the distal end surface of the handheld housing is defined as the vertical direction, and the direction parallel to the distal end surface of the handheld housing is defined as the horizontal direction; The driving part includes a power input unit, a power execution unit and a plurality of connecting sliding units; the connecting sliding units are respectively connected to the corresponding energy application units, and are slidably connected to the inner cavity of the handheld shell along the preset trajectory; the output end of the power input unit extends into the inner cavity of the handheld shell, and is connected to each of the connecting sliding units through the power execution unit; the power execution unit is configured to receive the power input of the power input unit, and convert the power input into driving each of the connecting sliding units and the energy application unit to slide laterally.

4. The multi-needle steep pulse ablation electrode device according to claim 3, characterized in that: The power input unit is a vertical power input mechanism, the power execution unit includes a vertical slider and an elastic force supply unit, and the connecting sliding unit is a horizontal slider provided with a guiding inclined surface; The input end of the vertical power input mechanism extends out of the handheld housing, and the output end of the vertical power input mechanism is connected to the vertical slider, which is used to drive the vertical slider to move vertically; the vertical slider is provided with a plurality of driving inclined surfaces arranged around, and the driving inclined surfaces are inclined toward the center of the distal end surface of the handheld housing; a plurality of transverse sliders are arranged around the circumference of the vertical slider, and the driving inclined surfaces correspond to the guide inclined surfaces one by one; the elastic force supply unit is respectively connected to each of the transverse sliders, and is used to provide an elastic force for the transverse slider to move toward the vertical slider; Driven by the elastic force supply unit, the guiding inclined surface of each of the transverse sliders is attached to the driving inclined surface, and the transverse position of the transverse slider relative to the vertical slider is adjusted along the preset trajectory according to the vertical relative position change of the vertical slider.

5. The multi-needle steep pulse ablation electrode device according to claim 4, characterized in that: The vertical power input mechanism includes a rotating member, an adjusting screw and a fixing nut; The fixing nut is fixed to the vertical slider; the adjusting screw is arranged vertically, and the adjusting screw is threadedly connected to the fixing nut; the rotating member is fixed to one end of the adjusting screw and extends out of the handheld housing; The rotating member includes a knob and a vertical elastic member; the bottom end of the knob is provided with an extension boss extending outwards, which is used to abut against the proximal end surface of the handheld housing; the two ends of the vertical elastic member are respectively connected to the extension boss and the vertical slider; The elastic force supply unit is an annular compression spring; An elastic member groove is provided on one side of each of the transverse slide blocks away from the center of the distal end surface of the handheld housing. The annular compression spring surrounds each of the transverse slide blocks and is embedded in the corresponding elastic member groove.

6. The multi-needle steep pulse ablation electrode device according to claim 4, characterized in that: The vertical slider includes a slider body, a vertical guide structure and a plurality of oblique guide structures arranged on the slider body; The outer contour of the vertical guide structure is in contact with the inner cavity wall of the handheld housing; the oblique guide structure includes two guide plates vertically and spaced apart on the slider body, and the lower ends of the two guide plates are each provided with an oblique cut surface facing the center of the distal end surface of the handheld housing, and the two corresponding oblique cut surfaces together form the driving inclined surface; A protruding structure is provided at the upper end of the transverse sliding block, and two sides of the protruding structure are respectively provided with inclined step surfaces that cooperate to form the guiding inclined surface; The transverse sliding block is provided with an embedding through groove which is arranged vertically and extends to the protruding structure.

7. The multi-needle steep pulse ablation electrode device according to claim 4, characterized in that: The lower end of the transverse sliding block is provided with an extension sliding platform extending toward at least one side of the preset track; The distal surface of the handheld shell is a distal bottom plate structure, which includes a chassis and a cover plate; the chassis is respectively provided with guide grooves corresponding to each of the preset trajectories, and the width of the guide grooves matches the overall size of the extension slide; the bottom surface of the guide groove is provided with a long strip through groove for the energy application unit to pass through; the cover plate is covered on the chassis and is provided with guide openings corresponding to the guide grooves one by one, and the width of the guide openings matches the width of the horizontal slider, and the chassis and the cover plate are respectively provided with insertion openings for the vertical slider to extend into.

8. The multi-needle steep pulse ablation electrode device according to claim 3, characterized in that: The power input unit is a rotating member, the power execution unit is a plurality of intermediate transmission members, and the connecting sliding unit is a transverse sliding member; The first ends of the plurality of intermediate transmission members are respectively rotatably connected to the rotating member and offset from the rotating axis of the rotating member, and at least part of the rotating member extends out of the handheld housing; The second end of the intermediate transmission member is rotatably connected to the transverse slider; The distal end surface of the handheld shell is a chassis, and the chassis is provided with a plurality of long strip through slots for the energy application unit to pass through, and the trajectory of the long strip through slots is the preset trajectory; the transverse slider slides on the chassis, and the energy application unit is clamped on the transverse slider and extends out of the corresponding long strip through slots.

9. The multi-needle steep pulse ablation electrode device according to claim 3, characterized in that: The power input unit is a vertical power input mechanism, the power execution unit is a plurality of oblique connecting rods, and the connecting sliding unit is a transverse sliding block; The input end of the vertical power input mechanism extends out of the handheld housing, and the output end of the vertical power input mechanism is respectively connected to the first end of each of the oblique connecting rods for rotation and / or swinging, so as to drive the first end of the oblique connecting rod to perform vertical movement; the second end of the oblique connecting rod is respectively connected to the corresponding transverse slider for rotation and / or swinging; The distal end surface of the handheld shell is a chassis, and the chassis is provided with a plurality of long strip through slots for the energy application unit to pass through, and the trajectory of the long strip through slots is the preset trajectory; the transverse slider slides on the chassis, and the energy application unit is clamped on the transverse slider and extends out of the corresponding long strip through slots.

10. The multi-needle steep pulse ablation electrode device according to claim 9, characterized in that: The power execution unit also includes a supporting link, a first end of which is rotatably and / or swingably connected to the handheld housing, and a second end of which is rotatably and / or swingably connected to a rod body of the oblique link.

11. The multi-needle steep pulse ablation electrode device according to claim 10, characterized in that: The vertical power input mechanism includes a rotating member, an adjusting screw, a connecting slider and a vertical elastic member; The adjusting screw is vertically arranged in the handheld shell, and the adjusting screw is threadedly connected to the proximal end surface of the handheld shell, the connecting slider is rotatably connected to the adjusting screw, and the connecting slider is respectively connected to the first end of each of the oblique connecting rods; the rotating member is fixed to one end of the adjusting screw and extends out of the handheld shell; the two ends of the vertical elastic member are respectively connected to the handheld shell and the connecting slider.

12. The multi-needle steep pulse ablation electrode device according to claim 1, characterized in that: The energy application unit is a metal puncture needle, and the number of the energy application units is three, four or five.

13. A method of using a multi-needle steep pulse ablation electrode device, characterized in that: include: A multi-needle steep pulse ablation electrode device is provided: the device further comprises a handheld housing, a plurality of energy application units and a driving part; The connection ends of the plurality of energy application units are configured to be inserted and slidably connected to the distal end surface of the handheld housing along a preset trajectory, and the execution ends of the plurality of energy application units are located in the same plane and cooperate to form an energy application execution area; The driving part is arranged in the handheld housing, and the power input end of the driving part extends out of the handheld housing, and the power output end of the driving part is respectively connected to the plurality of energy application units; the driving part is configured so that the power input end receives external power input, and the power output end outputs driving force to drive the plurality of energy application units to slide along the corresponding preset tracks respectively; The driving part is configured to receive external power input to drive each of the energy application units to slide along its preset trajectory to obtain the energy application execution area that matches the preset energy application area.

14. A radiofrequency ablation device, characterized in that: The area where the target tissue needs to be subjected to energy is defined as the preset radiofrequency ablation area, including: Handheld housing; A plurality of energy application units, wherein the connection ends of the energy application units are configured to be inserted into and slidably connected to the distal end surface of the handheld housing along a preset trajectory, and the execution ends of the plurality of energy application units are located in the same plane and cooperate to form a radiofrequency ablation execution area; A driving unit is disposed in the handheld housing, and a power input end of the driving unit extends out of the handheld housing, and a power output end of the driving unit is respectively connected to a plurality of the energy application units; The driving unit is configured such that the power input end receives external power input, and the power output end outputs driving force to drive the plurality of energy application units to slide along the preset trajectories corresponding to the energy application units, respectively, so as to adjust the radio frequency ablation execution area to match the preset radio frequency ablation area.

15. A tumor ablation device, characterized in that: include: A carrier carrying a plurality of treatment units; wherein the connection ends of the plurality of treatment units are configured to be inserted and slidably connected to the distal end surface of the carrier along a preset trajectory, and the execution ends of the treatment units are located in the same plane and cooperate to form an energy application execution area; The driving unit is arranged in the carrier, and the power output end of the driving unit is respectively connected to each of the treatment units; the driving unit is configured to drive each of the treatment units to slide along the corresponding preset trajectory to adjust the energy application execution area to match the preset tumor ablation area.

16. A minimally invasive medical system, characterized in that: A multi-needle steep pulse ablation electrode device comprising any one of claims 1 to 12.

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