Atomization product, and application method therefor and use thereof

Abstract

The present application relates to the field of atomization, and particularly to an atomization product. The atomization product comprises: an atomization agent, a functional substance and an atomizer. The atomization agent can be atomized to generate atomization agent aerosol. The atomizer comprises a first chamber and a second chamber which are separated by means of a separation mechanism, wherein the atomization agent is loaded into the first chamber, the functional substance is loaded into the second chamber, and the separation mechanism limits the atomization agent in the first chamber; and the second chamber is further provided with an inhaling port, the atomization agent aerosol penetrates through the separation mechanism from the first chamber to enter the second chamber, and comes into contact with the functional substance to form aerosol carrying the functional substance, and the aerosol carrying the functional substance is discharged through the inhaling port.

Description

Atomization products and their application methods and applications

[0001] This application claims priority to Chinese patent application No. 202310816135.4 filed on July 5, 2023, entitled “Atomization product, its application method, application, and preparation method of porous materials,” which is incorporated herein by reference in its entirety.

Technical field

[0002] The present application relates to the technical field of atomization products, and in particular to an atomization product and its application method and application. [Background Technology]

[0003] Atomization technology, which involves dispersing liquids into tiny droplets through a nozzle or high-speed airflow, has been widely used in the medical and tobacco sectors. In the medical field, for example, a medical nebulizer can atomize solid or liquid medications into tiny particles, which are then absorbed by the respiratory tract and lungs through inhalation, achieving the goal of painless, rapid, and effective treatment of respiratory and neurological diseases. In the tobacco sector, atomization technology is also a key component of the e-cigarette industry. For example, in heat-not-burn (HNB) cigarettes, the smoking section of the cigarette is heated to produce an aerosol.

[0004] [Summary of the invention]

[0005] Based on this, it is necessary to provide an atomization product and its application method and application that can improve the performance stability of functional substances and thus have a better suction effect.

[0006] An embodiment of the present application provides an atomization product, comprising: an atomizer, a functional substance, and an atomizer;

[0007] The atomizer can generate an atomizer aerosol after atomization;

[0008] The nebulizer comprises a first cavity and a second cavity separated by an isolation mechanism, the nebulizer is loaded in the first cavity, the functional substance is loaded in the second cavity, and the isolation mechanism confines the nebulizer in the first cavity;

[0009] The second cavity is also provided with an air inlet. The aerosol of the atomizer passes through the isolation mechanism from the first cavity into the second cavity and contacts with the functional substance to form an aerosol carrying the functional substance. The aerosol carrying the functional substance is discharged from the air inlet.

[0010] In one embodiment, the aerosolizing agent comprises an inert liquid that can be atomized to form an aerosol;

[0011] In one embodiment, the atomization temperature of the atomizer is ≤250°C;

[0012] In one embodiment, the atomizer includes one or more of water, propylene glycol, glycerin, limonene, and glyceride substances;

[0013] In one embodiment, the glyceride substance includes one or more of triacetin and caprylic decanoic acid glyceride.

[0014] In one embodiment, the functional substance includes at least one of a substance having biological activity and a substance having sensory properties;

[0015] In one embodiment, the biologically active substance comprises one or more of ketotifen, rimantadine, and nicotine;

[0016] In one embodiment, the substance with organoleptic properties includes one or more of essence, essential oil, cooling agent and sweetener.

[0017] In one embodiment, the second cavity is further loaded with a first solid carrier, and the functional substance is loaded on the first solid carrier;

[0018] In one embodiment, the loading amount of the functional substance is ≥0.05%.

[0019] In one embodiment, the first cavity is further loaded with a second solid carrier, and the aerosol is loaded on the second solid carrier;

[0020] In one embodiment, the loading amount of the aerosol agent is ≥20%.

[0021] In one embodiment, the first solid support and the second solid support are each independently selected from a porous material having physical adsorption capacity;

[0022] In one embodiment, the water content of the porous material having physical adsorption capacity is ≤8%;

[0023] In one embodiment, the chemical composition of the porous material having physical adsorption ability includes one or more of starch and cellulose;

[0024] In one embodiment, the cellulose comprises one or more of natural plant cellulose, microcrystalline cellulose, methylcellulose and hydroxypropyl methylcellulose.

[0025] In one embodiment, the method of loading the functional substance onto the first solid carrier comprises the following steps: spraying a liquid containing the functional substance onto the first solid carrier;

[0026] The method of loading the atomizer on the second solid carrier includes the following steps: spraying the liquid containing the atomizer on the second solid carrier.

[0027] In one embodiment, the isolation mechanism has at least one air vent, and the diameter of the air vent is smaller than the diameters of the first solid carrier and the second solid carrier.

[0028] In one embodiment, during the process of the atomizer aerosol contacting the functional substance to form the aerosol carrying the functional substance, the temperature of the atomizer aerosol is ≤150°C.

[0029] In one embodiment, the temperature of the aerosol carrying the functional substance discharged from the inhalation port is ≤ 40°C.

[0030] One embodiment of the present application further provides a method for applying the atomized product as described in any of the above embodiments, comprising the following steps:

[0031] Atomizing the atomizing agent to generate the atomizing agent aerosol;

[0032] Inhalation is performed through the inhalation port, and the aerosol of the atomizer passes through the isolation mechanism from the first cavity into the second cavity and contacts the functional substance to form an aerosol carrying the functional substance, and the aerosol carrying the functional substance is discharged from the inhalation port.

[0033] One embodiment of the present application also provides an application of the atomization product described in any of the above embodiments in the field of medical products or in the field of tobacco.

[0034] An embodiment of the present application further provides a method for preparing a porous material with physical adsorption capacity, comprising the following steps: mixing chemical components of the porous material with physical adsorption capacity with water, granulating the mixture, and drying the mixture.

[0035] The present application provides an atomization product, including an atomizer, a functional substance, and an atomizer. The atomizer and the functional substance are located in different cavities of the atomizer and are isolated by an isolation mechanism. During daily product storage, the atomizer and the functional substance do not contact each other. During inhalation, the atomizer aerosol passes through the isolation mechanism from the first cavity of the atomizer into the second cavity. The temperature of the atomizer aerosol gradually decreases during the flow process, and when in contact with the functional substance, it has a lower suitable temperature to ensure the stable performance of the functional substance, avoid long-term contact between the atomizer and the functional substance, or avoid adverse effects such as deterioration of the functional substance due to excessively high atomization temperature, so that the performance of the functional substance is more stable and controllable, which can greatly improve the suction effect of the atomization product.

Brief Description of the Drawings

[0036] The accompanying drawings are incorporated into and constitute a part of the specification, illustrate embodiments consistent with the present disclosure, and together with the specification, are used to explain the principles of the present disclosure. Obviously, the drawings described below are only some embodiments of the present disclosure, and those skilled in the art can derive other drawings based on these drawings without inventive effort.

[0037] FIG1 is a schematic structural diagram of an atomizer in one embodiment.

[0038] FIG2 is a schematic structural diagram of the atomization product in Examples 1, 2, 3, and 6.

[0039] FIG3 is a schematic structural diagram of the atomization product in Examples 4, 5, 7, and 8.

[0040] FIG4 is a schematic structural diagram of the atomization product in Comparative Example 1.

[0041] FIG5 is a schematic structural diagram of the atomization product in Comparative Example 2.

[0042] FIG6 is a schematic structural diagram of the atomization product in Comparative Example 3.

[0043] Explanation of reference numerals: 10: atomizer; 110: isolation mechanism; 120: first cavity; 130: second cavity; 140: air inlet; 150: filtering mechanism; 20: first solid carrier; 30: functional substance; 40: atomizer; 50: second solid carrier. [Specific implementation method]

[0044] Example embodiments will now be described more fully with reference to the accompanying drawings. However, example embodiments can be implemented in many forms and should not be construed as limited to the examples set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete and will fully convey the concepts of the example embodiments to those skilled in the art.

[0045] In addition, the described features, structures or characteristics may be combined in any suitable manner in one or more embodiments. In the following description, many specific details are provided to provide a full understanding of the embodiments of the present disclosure. However, those skilled in the art will appreciate that the technical solutions of the present disclosure can be practiced without one or more of the specific details, or other methods, components, devices, steps, etc. can be adopted. In other cases, well-known methods, devices, implementations or operations are not shown or described in detail to avoid blurring various aspects of the present disclosure.

[0046] The present disclosure is further described below in conjunction with the accompanying drawings and specific embodiments. It should be noted that the technical features involved in the various embodiments of the present disclosure described below can be combined with each other as long as they do not conflict with each other. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to explain the present disclosure, and should not be construed as limiting the present disclosure.

[0047] It should be noted that the term "plurality" used in this document refers to two or more. "And / or" describes a relationship between associated objects, indicating that three possible relationships exist. For example, "A and / or B" can represent: A alone, A and B together, or B alone. The character " / " generally indicates an "or" relationship between the associated objects.

[0048] To facilitate understanding of the present application, the present application will be described more fully below in conjunction with the embodiments and accompanying drawings. The present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive.

[0049] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this application pertains. The terms used herein in the specification of this application are intended solely for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0050] In this application, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.

[0051] An embodiment of the present application provides an atomization product, comprising: an atomizer, a functional substance, and an atomizer;

[0052] The nebulizer can generate nebulizer aerosol after being atomized;

[0053] The nebulizer includes a first cavity and a second cavity separated by an isolation mechanism, the nebulizer is loaded in the first cavity, the functional substance is loaded in the second cavity, and the isolation mechanism confines the nebulizer in the first cavity;

[0054] The second cavity is also provided with an air inlet. The aerosol of the atomizer passes through the isolation mechanism from the first cavity into the second cavity and contacts with the functional substance to form an aerosol carrying the functional substance. The aerosol carrying the functional substance is discharged from the air inlet.

[0055] The present application provides an atomization product, including an atomizer, a functional substance, and an atomizer. The atomizer and the functional substance are located in different cavities of the atomizer and are isolated by an isolation mechanism. During daily product storage, the atomizer and the functional substance do not contact each other. During inhalation, the atomizer aerosol passes through the isolation mechanism from the first cavity of the atomizer into the second cavity. The temperature of the atomizer aerosol gradually decreases during the flow process, and when in contact with the functional substance, it has a lower suitable temperature to ensure the stable performance of the functional substance, avoid long-term contact between the atomizer and the functional substance, or avoid adverse effects such as deterioration of the functional substance due to excessively high atomization temperature, so that the performance of the functional substance is more stable and controllable, which can greatly improve the suction effect of the atomization product.

[0056] Furthermore, the atomizer provided by the present application has a simple structure and can be made into a product with a smaller volume, which is easy to carry, convenient to use, and highly private.

[0057] In one embodiment, the aerosolizing agent comprises an inert liquid that can be atomized to form an aerosol.

[0058] Optionally, the atomization temperature of the atomizer is ≤250°C.

[0059] Optionally, the atomizer includes one or more of water, propylene glycol, glycerin, limonene and glyceride substances.

[0060] Further optionally, the glyceride substance includes one or more of triacetin and caprylic decanoic acid glyceride.

[0061] In one embodiment, the functional substance includes at least one of a substance having biological activity and a substance having sensory properties.

[0062] Bioactive substances are substances that produce biological effects on the inhaler when inhaled. In the medical field, bioactive substances can be, for example, drugs that prevent or treat diseases, such as ketotifen for asthma treatment and rimantadine for influenza prevention and treatment. In the tobacco industry, bioactive substances can be substances that stimulate nerves, such as nicotine.

[0063] Substances with sensory properties are substances with characteristics such as smell, color, and taste. Examples include flavors, essential oils, cooling agents, and sweeteners. Cooling agents can be natural or artificial, such as menthol and WS-23, and sweeteners such as neotame and sucralose.

[0064] In one embodiment, the second cavity is also loaded with a first solid carrier, on which the functional substance is loaded. Because the functional substance in the aerosol product is intended for inhalation, the dosage of the functional substance is generally low. Loading the functional substance in the first solid carrier makes it more convenient to contain the functional substance in the first cavity. Furthermore, this solid-state loading method can make low levels of the functional substance in the product more stable and controllable.

[0065] Optionally, the loading amount of the functional substance is ≥ 0.05%. By controlling the loading amount of the functional substance on the first solid carrier within an appropriate range, the dosage of the functional substance carried by the aerosol can be controlled to achieve the desired inhalation effect. Preferably, the loading amount of the functional substance is 0.1% to 67%.

[0066] In one embodiment, the first cavity further contains a second solid carrier, on which the aerosol is loaded. In some application scenarios, liquid aerosol is easily leaked when directly loaded into the aerosolizer. Loading the aerosol on the second solid carrier can effectively avoid leakage.

[0067] Optionally, the loading amount of the aerosolizing agent is ≥ 20%. By controlling the loading amount of the aerosolizing agent on the second solid carrier within an appropriate range, the aerosolizing agent can be controlled to generate sufficient aerosolizing agent to effectively carry out the functional substance. Preferably, the loading amount of the aerosolizing agent is 20% to 67%.

[0068] It can be understood that in the present application, the loading amount of the functional substance = the mass of the functional substance / (the mass of the functional substance + the mass of the first solid carrier) × 100%; the loading amount of the atomizer = the mass of the atomizer / (the mass of the atomizer + the mass of the second solid carrier) × 100%.

[0069] In one embodiment, the first solid carrier and the second solid carrier are each independently selected from a porous material having physical adsorption capacity. The porous material having physical adsorption capacity can effectively adsorb the functional substance or the aerosol agent, and during use, can significantly improve the release of the functional substance or the aerosol agent compared to a compact structure. Furthermore, compared with a compact structure, when the atomizer is loaded on a second solid carrier with a loose porous structure, the atomizer heats up more evenly during heating and atomization, and can form an atomizer aerosol more quickly and release it from the pores of the second solid carrier; when the functional substance is loaded on a first solid carrier with a loose porous structure, the atomizer aerosol can enter the internal pores of the first solid carrier when passing through the first solid carrier loaded with the functional substance during the process of being inhaled, thereby increasing the contact area between the functional substance and the atomizer aerosol, so that the atomizer aerosol can carry out the functional substance more efficiently, and the functional substance can be released more stably at a lower temperature. The porous material with physical adsorption capacity has a better cooling effect on the atomizer aerosol. Using it as the first solid carrier can help reduce the temperature of the aerosol when it is discharged from the air inlet, avoiding overheating and burns to the human body.

[0070] Optionally, the porous material with physical adsorption capacity has a water content of ≤8%. For the first solid carrier, the lower the water content of the porous material with physical adsorption capacity, the better the adsorption performance for the functional substance. Furthermore, the functional substance is more easily desorbed from the first solid carrier after contact with the atomizer aerosol. Excessive water content will weaken the desorption performance, affecting the release of the functional substance. For the second solid carrier, the lower the water content of the porous material with physical adsorption capacity, the more conducive it is to reducing the temperature of the aerosol discharged from the air inlet. Excessive water content will cause the aerosol to be hot when it is inhaled, potentially burning the mouth, due to the high specific heat capacity of water.

[0071] Optionally, the chemical components of the porous material having physical adsorption capacity include one or more of starch and cellulose.

[0072] Optionally, the cellulose includes one or more of natural plant cellulose, microcrystalline cellulose, methylcellulose, hydroxypropyl methylcellulose, and other derivatized celluloses.

[0073] Preferably, the porous material with physical adsorption capacity is composed of natural plant cellulose or a mixture of natural plant cellulose and other celluloses, with the amount of other cellulose added not exceeding 10% of the total cellulose mass. Derivatized celluloses such as methylcellulose and hydroxypropyl methylcellulose have good adsorption properties but poor desorption properties. In contrast, natural plant cellulose exhibits both good adsorption and desorption properties.

[0074] In one embodiment, the method of loading the functional substance onto the first solid carrier comprises the following steps: spraying a liquid containing the functional substance onto the first solid carrier. In one embodiment, the method of loading the atomizer onto the second solid carrier comprises the following steps: spraying a liquid containing the atomizer onto the second solid carrier. After first preparing a solid carrier with a loose porous structure, and then loading the atomizer or functional substance onto the solid carrier, compared to directly mixing the chemical components of the functional substance and the solid carrier and then granulating, it can ensure the stability of the dosage and performance of the functional substance or atomizer, and has no effect on the biological properties or sensory characteristics of the functional substance. Moreover, this loading method is more conducive to the dissociation of the atomizer or functional substance from the solid carrier, and the release is more efficient.

[0075] In one embodiment, the isolation mechanism has at least one air vent, and the diameter of the air vent is smaller than the diameter of the first solid carrier and the second solid carrier. The isolation mechanism can store the atomizer and the functional substance separately. Before use, the two are isolated from each other and do not affect each other, ensuring that the quality of the atomized product is more stable. During use, the atomizer needs to be atomized at a higher temperature to form an atomized aerosol. Separating the functional substance from the atomizer through the isolation mechanism can avoid excessively high atomization temperature from causing adverse effects on the performance of the functional substance, such as inactivation of drug efficacy, too fast release, etc. The diameter of the air vent of the isolation mechanism is smaller than the diameter of the first solid carrier and the second solid carrier, which can ensure that the first solid carrier and the second solid carrier are respectively confined to the corresponding cavities, and only the atomizer aerosol can flow between the first cavity and the second cavity.

[0076] In one embodiment, during the process of the atomizer aerosol contacting the functional substance to form the aerosol carrying the functional substance, the temperature of the atomizer aerosol is ≤150°C. The temperature of the atomizer aerosol is lower than the atomization temperature, but it still has a good ability to carry out the functional substance. Preferably, during the process of the atomizer aerosol contacting the functional substance to form the aerosol carrying the functional substance, the temperature of the atomizer aerosol is ≤100°C. Further preferably, during the process of the atomizer aerosol contacting the functional substance to form the aerosol carrying the functional substance, the temperature of the atomizer aerosol is ≤80°C.

[0077] In one embodiment, the temperature of the aerosol carrying the functional substance discharged from the air inlet is ≤40°C. The temperature of the aerosol is highest when the atomizer is generated at the atomization temperature. During the discharge process, the temperature of the aerosol gradually decreases. Controlling the temperature of the aerosol carrying the functional substance discharged from the air inlet within 40°C can prevent burns caused by excessive temperature.

[0078] In one embodiment, as shown in FIG1 , a schematic structural diagram of an atomizer is provided:

[0079] The atomizer 10 includes a first cavity 120 and a second cavity 130 separated by an isolation mechanism 110 . The atomizer is loaded in the first cavity 120 , and the functional substance is loaded in the second cavity 130 .

[0080] The second cavity 130 is also provided with an inhalation port 140 . Air is inhaled through the inhalation port 140 . The aerosol of the atomizer passes through the isolation mechanism 110 from the first cavity 120 into the second cavity 130 , and contacts with the functional substance to form an aerosol carrying the functional substance. The aerosol carrying the functional substance is discharged from the inhalation port 140 .

[0081] It is understood that the inhalation port 140 can be located anywhere within the second cavity 130, as long as inhalation through the inhalation port 140 effectively expel the aerosol carrying the functional substance. For example, the entire end of the second cavity 130, away from the isolation mechanism 110, can serve as the inhalation port 140. It is understood that after being expelled from the inhalation port 140, the aerosol carrying the functional substance can enter the human body through the oral cavity and respiratory tract.

[0082] Furthermore, the second cavity 130 is further provided with a filtering mechanism 150 in a direction away from the isolation mechanism 110, the air inlet 140 is provided on the filtering mechanism 150, and the functional substance is loaded between the isolation mechanism 110 and the filtering mechanism 150. During inhalation, the aerosol of the atomizer enters the second cavity 130 and first contacts with the functional substance to form an aerosol carrying the functional substance. The aerosol carrying the functional substance passes through the filtering mechanism 150 and is discharged from the air inlet 140. The filtering mechanism 150 can further reduce the temperature of the inlet aerosol to prevent burns to the oral cavity and respiratory mucosa. Furthermore, when the atomizer or functional substance is loaded on a solid carrier, the filtering mechanism 150 can also be used to filter solid carrier particles or dust to avoid inhaling dust particles into the oral cavity or respiratory tract, thereby reducing possible respiratory irritation. Furthermore, the material of the filtering mechanism can be, for example, but not limited to, acetate fiber, propionate fiber, etc.

[0083] One embodiment of the present application further provides a method for applying the atomized product as in any of the above embodiments, comprising the following steps:

[0084] atomizing the atomizing agent to generate an atomizing agent aerosol;

[0085] Inhale through the inhalation port, and the atomizer aerosol passes through the isolation mechanism from the first cavity into the second cavity and contacts with the functional substance to form an aerosol carrying the functional substance, which is then discharged from the inhalation port.

[0086] In one embodiment, the atomizing agent is atomized by heating. Furthermore, the bottom of the first cavity is heated to a temperature where the atomizing agent in the first cavity reaches an atomization temperature for atomization. Furthermore, the heating source can be located within or outside the first cavity.

[0087] One embodiment of the present application further provides applications of the atomization product described in any of the above embodiments in the medical product field or the tobacco field. Furthermore, in the medical product field, the atomization product can be used as a medical atomizer; in the tobacco field, the atomization product can be used in heat-not-burn tobacco, electronic cigarettes, and traditional cigarettes.

[0088] An embodiment of the present application further provides a method for preparing a porous material with physical adsorption capacity, comprising the following steps: mixing chemical components of the porous material with physical adsorption capacity with water, granulating the mixture, and drying the mixture.

[0089] Granulation and drying can produce porous materials that are more compatible with the adsorption and desorption of atomizers or functional substances. Granulation methods include, but are not limited to, rotary extrusion granulation, screw extrusion granulation, fluidized bed granulation, dry granulation, and the like.

[0090] The following specific examples further illustrate the atomization product of the present application and its application method and application. It is understood that in the following specific examples, unless otherwise specified, all raw materials can be sourced from commercial sources.

[0091] Example 1

[0092] See Figure 2:

[0093] (1) Preparation of the first solid carrier 20: 1000 g of medicinal starch was placed in a mixer, and 1000 g of an aqueous solution containing 5% pregelatinized starch was added while stirring. After stirring for a while, an appropriate amount of water was added to adjust the viscosity and moisture content of the starch. The starch was granulated using a rotary granulator to obtain starch granules. The drying conditions were controlled and the starch was screened to obtain porous starch granules with a particle size of 20 to 24 mesh and a water content of 5%.

[0094] (2) Loading the functional substance 30 on the first solid carrier 20: 90 g of the porous starch granules prepared in step (1) were placed in a mixer, and 50 g of a hot ethanol solution containing 0.2% ketotifen was sprayed onto the porous starch granules in batches while stirring. The mixture was stirred in the mixer for half an hour at 40° C. to remove the ethanol and cooled to room temperature. Then, 10 g of sweet orange essential oil was sprayed onto the porous starch granules at room temperature to prepare a first solid carrier 20 loaded with the functional substance 30 (the ketotifen loading amount was about 0.1%, and the sweet orange essential oil loading amount was about 10%).

[0095] (3) Preparing and applying the atomized product: providing an atomizer 10, the atomizer 10 including a first cavity 120 and a second cavity 130 separated by an isolation mechanism 110, the second cavity 130 being provided with a filter mechanism 150 in a direction away from the isolation mechanism 110, and the air inlet 140 being provided on the filter mechanism 150. Propylene glycol is added as the atomizer 40 into the first cavity 120 of the nebulizer 10, and 0.1 g of the first solid carrier 20 loaded with the functional substance 30 prepared in step (2) is added into the second cavity 130 of the nebulizer 10 and is located between the isolation mechanism 110 and the filtering mechanism 150. The first cavity 120 is heated by an external heat source so that the atomizer 40 reaches an atomization temperature to form an atomizer aerosol. Inhalation is performed from the air inlet 140, and the atomizer aerosol is sucked out. During the aspiration process, the atomizer aerosol contacts the particles of the first solid carrier 20 loaded with the functional substance 30, so that ketotifen and sweet orange essential oil are dissociated from the first solid carrier 20, and the ketotifen and sweet orange essential oil are carried out to form an aerosol carrying the functional substance. The aerosol carrying the functional substance is discharged from the air inlet 140.

[0096] After 20 consecutive puffs, no functional substance 30 was released after simulating suction with a suction machine (parameters were set to: flow rate 18.3 mL / s, continuous 3 seconds of simulated inhalation, followed by 5 seconds of simulated exhalation). Analysis showed that the collected aerosol contained a total of 0.05 mg of ketotifen, and the total release rate of ketotifen was 50%. Tested with an infrared thermometer, the aerosol temperature from the filter mechanism 150 to the air inlet 140 was a maximum of about 37 ° C, which was not hot. The atomized product provided in this embodiment can achieve oral mucosal and pulmonary administration of ketotifen and can be used to prevent asthma attacks in daily use.

[0097] Example 2

[0098] See Figure 2:

[0099] (1) Preparation of the first solid carrier 20: 1000 g of natural cellulose with a length and width of 30 μm or less was placed in a mixer, and 1000 g of an aqueous solution containing 5% pregelatinized starch was added while stirring. After stirring for a while, an appropriate amount of water was added to adjust the viscosity and humidity of the cellulose. Cellulose particles were obtained after granulation and shaping. The drying conditions were controlled and porous cellulose particles with a particle size of 20 to 24 mesh and a water content of 2.5% were screened through a sieve.

[0100] (2) Loading the functional substance 30 on the first solid carrier 20: 90 g of the cellulose particles prepared in step (1) were placed in a mixer, and 100 g of a hot ethanol solution containing 1% ketotifen was sprayed onto the porous cellulose particles in batches while stirring. The mixture was stirred in the mixer at 50° C. for half an hour to remove the ethanol, and then 9 g of sweet orange essential oil was sprayed onto the porous cellulose particles at room temperature to prepare a first solid carrier 20 loaded with the functional substance 30 (the loading amount of ketotifen was 1%, and the loading amount of sweet orange essential oil was 9%).

[0101] (3) Preparing and applying the atomized product: providing an atomizer 10, the atomizer 10 including a first cavity 120 and a second cavity 130 separated by an isolation mechanism 110, the second cavity 130 being provided with a filter mechanism 150 in a direction away from the isolation mechanism 110, and the air inlet 140 being provided on the filter mechanism 150. A mixed solvent of propylene glycol and glycerol (mass ratio 1:1) is added as an atomizer 40 into the first cavity 120 of the atomizer 10, 0.1 g of the first solid carrier 20 loaded with the functional substance 30 prepared in step (2) is added into the second cavity 130 of the atomizer 10 and is located between the isolation mechanism 110 and the filtering mechanism 150, the first cavity 120 is heated by an external heat source so that the atomizer 40 reaches an atomization temperature to form an atomizer aerosol, and air is inhaled from the air inlet 140, and the atomizer aerosol is sucked out. During the aspiration process, the atomizer aerosol contacts the first solid carrier 20 loaded with the functional substance 30, so that ketotifen and sweet orange essential oil are dissociated from the first solid carrier 20, and the ketotifen and sweet orange essential oil are carried out to form an aerosol carrying the functional substance, which is discharged from the air inlet 140.

[0102] After 20 consecutive puffs, no functional substance 30 was released after simulating suction with a suction machine (parameters were set as follows: flow rate 18.3 mL / s, continuous 3 seconds of simulated inhalation, and then simulated exhalation 5 seconds). Analysis showed that the collected aerosol contained a total of 0.7 mg of ketotifen, and the total release rate of ketotifen was 70%. Tested with an infrared thermometer, the aerosol temperature from the filter mechanism 150 to the air inlet 140 was a maximum of about 32°C, which was not hot. The atomized product provided in this embodiment can achieve oral mucosal and pulmonary administration of ketotifen and can be used to prevent and treat asthma in daily use.

[0103] Example 3

[0104] Please refer to Figure 2

[0105] (1) Preparation of the first solid carrier 20: Referring to the method of step (1) of Example 2, the drying conditions were adjusted to prepare porous cellulose particles with a water content of 6%.

[0106] (2) Loading the functional substance 30 on the first solid carrier 20: 90 g of the cellulose particles prepared in step (1) were placed in a mixer, and 100 g of a hot ethanol solution containing 5% rimantadine was sprayed onto the porous cellulose particles in batches while stirring. The solution was dried in an explosion-proof drying oven at 50° C. for half an hour to remove the ethanol. Then, 5 g of peppermint oil was sprayed onto the porous cellulose particles at room temperature to prepare a first solid carrier 20 loaded with the functional substance 30 (the loading amount of rimantadine was 5%, and the loading amount of peppermint oil was 5%).

[0107] (3) Preparing and applying the atomized product: providing an atomizer 10, the atomizer 10 including a first cavity 120 and a second cavity 130 separated by an isolation mechanism 110, the second cavity 130 being provided with a filter mechanism 150 in a direction away from the isolation mechanism 110, and the air inlet 140 being provided on the filter mechanism 150. A mixed solvent of propylene glycol and glycerol (mass ratio 2:3) is added as an atomizer 40 into the first cavity 120 of the nebulizer 10. 0.2 g of the first solid carrier 20 loaded with the functional substance 30 prepared in step (2) is added into the second cavity 130 of the nebulizer 10 and is located between the isolation mechanism 110 and the filtering mechanism 150. The first cavity 120 is heated by an external heat source so that the atomizer 40 reaches an atomization temperature to form an atomizer aerosol. Inhalation is performed from the air inlet 140 and the atomizer aerosol is aspirated. During the aspiration process, the atomizer aerosol contacts the first solid carrier 20 loaded with the functional substance 30, causing rimantadine and peppermint oil to dissociate from the first solid carrier 20, and the rimantadine and peppermint oil are carried out to form an aerosol carrying the functional substance. The aerosol carrying the functional substance is discharged from the air inlet 140.

[0108] After 22 consecutive puffs of simulated suction using a suction machine (parameters set to: flow rate 18.3 mL / s, 3 seconds of simulated inhalation, followed by 5 seconds of simulated exhalation), no more functional substance 30 was released. Analysis showed that the collected aerosol contained a total of 8 mg of rimantadine, and the total release rate of rimantadine was 80%. Tested with an infrared thermometer, the aerosol temperature from the filter mechanism 150 to the air inlet 140 was a maximum of approximately 38°C, which was not hot. The atomized product provided in this embodiment can achieve oral mucosal and pulmonary administration of rimantadine and can be used for the prevention and treatment of influenza in daily use.

[0109] Example 4

[0110] See Figure 3:

[0111] (1) Preparation of the first solid carrier 20 and the second solid carrier 50: Referring to the method of step (1) of Example 2, the natural cellulose was replaced with tea stem powder (containing natural cellulose), and the drying conditions were adjusted to prepare porous tea stem particles with a moisture content of 7.6%.

[0112] (2) Loading the functional substance 30 on the first solid carrier 20: 90 g of the porous tea stem particles prepared in step (1) are placed in a mixer, and 100 g of a hot ethanol solution containing 1% ketotifen is sprayed onto the porous tea stem particles in batches while stirring. The mixture is stirred in the mixer for half an hour at 50° C. to remove the ethanol, and then 9 g of sweet orange essential oil is sprayed onto the porous tea stem particles at room temperature to prepare a first solid carrier 20 loaded with the functional substance 30 (the loading amount of ketotifen is 1%, and the loading amount of sweet orange essential oil is 9%).

[0113] (3) Loading the atomizer 40 on the second solid carrier 50: Take 10 g of the porous tea stem particles prepared in step (1) and place them in a mixer. While stirring at 60°C, 10 g of glycerol is sprayed onto the porous tea stem particles in batches to prepare a second solid carrier 50 loaded with the atomizer 40 (the loading amount of the glycerol atomizer is 50%).

[0114] (4) Preparing and applying the atomized product: providing an atomizer 10 , the atomizer 10 comprising a first cavity 120 and a second cavity 130 separated by an isolation mechanism 110 , the second cavity 130 being provided with a filter mechanism 150 in a direction away from the isolation mechanism 110 , and the air inlet 140 being provided on the filter mechanism 150 . The second solid carrier 50 loaded with the atomizer 40 prepared in step (3) is added to the first cavity 110 of the nebulizer 10, and 0.1 g of the first solid carrier 20 loaded with the functional substance 30 prepared in step (2) is added to the second cavity 130 of the nebulizer 10 and is located between the isolation mechanism 110 and the filtering mechanism 150. The first cavity 120 is heated by an external heat source so that the glycerol in the second solid carrier 50 loaded with the atomizer 40 reaches an atomization temperature to form an atomizer aerosol. Inhalation is performed from the air inlet 140, and the atomizer aerosol is sucked out. During the aspiration process, the atomizer aerosol contacts the first solid carrier 20 loaded with the functional substance 30, so that ketotifen and sweet orange essential oil are dissociated from the first solid carrier 20, and the ketotifen and sweet orange essential oil are carried out to form an aerosol carrying the functional substance. The aerosol carrying the functional substance is discharged from the air inlet 140.

[0115] After 20 consecutive puffs, no functional substance 30 was released after simulating suction with a suction machine (parameters were set to: flow rate 18.3 mL / s, continuous 3 seconds of simulated inhalation, followed by 5 seconds of simulated exhalation). Analysis showed that the collected aerosol contained a total of 0.71 mg of ketotifen, and the total release rate of ketotifen was 71%. Tested with an infrared thermometer, the aerosol temperature from the filter mechanism 150 to the air inlet 140 was a maximum of about 36 ° C, which was not hot. The atomized product provided in this embodiment can achieve oral mucosal and pulmonary administration of ketotifen and can be used to prevent asthma attacks in daily use.

[0116] Example 5

[0117] See Figure 3:

[0118] (1) Preparation of the first solid carrier 20 and the second solid carrier 50: Referring to the method of step (1) of Example 2, the drying conditions were adjusted to prepare porous cellulose particles with a water content of less than 2.5%.

[0119] (2) Loading the functional substance 30 on the first solid carrier 20: 10 g of the porous cellulose particles prepared in step (1) were placed in a mixer. 10 g of mango essence was sprayed onto the porous cellulose particles in batches while stirring at 50° C. to prepare a first solid carrier 20 loaded with the functional substance 30 (the loading amount of mango essence was 50%).

[0120] (3) Loading the atomizer 40 on the second solid carrier 50: Take 10 g of the porous cellulose particles prepared in step (1) and place them in a mixer. While stirring at 60°C, 10 g of atomizer (3 g of propylene glycol, 5 g of glycerol, and 2 g of caprylic acid glyceride) is sprayed onto the porous cellulose particles in batches to prepare a second solid carrier 50 loaded with the atomizer 40 (the loading amount of the atomizer is 50%).

[0121] (4) Preparing and applying the atomized product: providing an atomizer 10 , the atomizer 10 comprising a first cavity 120 and a second cavity 130 separated by an isolation mechanism 110 , the second cavity 130 being provided with a filter mechanism 150 in a direction away from the isolation mechanism 110 , and the air inlet 140 being provided on the filter mechanism 150 . The second solid carrier 50 loaded with the atomizer 40 prepared in step (3) is added to the first cavity 120 of the atomizer 10, and 0.1 g of the first solid carrier 20 loaded with the functional substance 30 prepared in step (2) is added to the second cavity 130 of the atomizer 10 and is located between the isolation mechanism 110 and the filtering mechanism 150. The first cavity 120 is heated by an external heat source so that the atomizer 40 in the second solid carrier 50 reaches an atomization temperature to form an atomizer aerosol. Inhalation is performed from the air inlet 140, and the atomizer aerosol is sucked out. During the aspiration process, the atomizer aerosol contacts the first solid carrier 20 loaded with the functional substance 30, so that the flavor is dissociated from the first solid carrier 20, and the flavor is carried out to form an aerosol carrying the functional substance. The aerosol carrying the functional substance is discharged from the air inlet 140.

[0122] Upon artificial inhalation, the mango flavor was distinct and well-balanced from puff to puff. The area contacting the lips did not feel hot or scalding, demonstrating good overall comfort. Testing with an infrared thermometer revealed that the aerosol temperature from the filter mechanism 150 to the inhalation port 140 reached a maximum of approximately 35°C, which was not scalding. The atomizer product provided in this embodiment can be used in heat-not-burn cigarettes, enhancing the aroma and lowering the aerosol temperature.

[0123] Example 6

[0124] See Figure 2:

[0125] (1) Preparation of the first solid carrier 20: The method is the same as step (1) of Example 1, using starch, natural cellulose, tea stem powder and hydroxypropyl methylcellulose as the base materials of the first solid carrier, respectively. The drying conditions are controlled to obtain porous starch particles with a water content of 5%, porous natural cellulose particles with a water content of 5%, porous tea stem particles with a water content of 5%, and porous hydroxypropyl methylcellulose particles with a water content of 5%.

[0126] (2) Loading the functional substance 30 onto the first solid carrier 20: The method is the same as that in step (2) of Example 1, and porous starch particles loaded with the functional substance 30, porous natural cellulose particles loaded with the functional substance 30, porous tea stem particles loaded with the functional substance 30, and porous hydroxypropyl methylcellulose particles loaded with the functional substance are obtained respectively. The loaded functional substance is 2% nicotine benzoate.

[0127] (3) Preparing and applying the atomized product: The porous starch particles loaded with the functional substance 30, the porous natural cellulose particles loaded with the functional substance 30, the porous tea stem particles loaded with the functional substance 30, and the porous hydroxypropyl methylcellulose particles loaded with the functional substance 30 are added into the second cavity 130 of different atomizers 10 respectively and applied.

[0128] After simulated puffing using a suction machine (parameter settings: flow rate 18.3 mL / s, simulated inhalation for 3 seconds, followed by simulated exhalation for 5 seconds), the total release rate of nicotine benzoate in the atomized product with porous starch particles as the first solid carrier 20 was 50%, the total release rate of nicotine benzoate in the atomized product with porous natural cellulose particles as the first solid carrier 20 was 73%, and the total release rate of nicotine benzoate in the atomized product with porous tea stem particles as the first solid carrier 20 was 80%. The total release rate of nicotine benzoate in the atomized product with porous hydroxypropyl methylcellulose particles as the first solid carrier 20 was 65%.

[0129] According to the test of infrared thermometer, the maximum aerosol temperature of the atomized product whose first solid carrier 20 is porous starch particles passing through the filtering mechanism 150 to the air inlet 140 is about 50°C, which is not hot to the mouth; the maximum aerosol temperature of the atomized product whose first solid carrier 20 is porous natural cellulose particles passing through the filtering mechanism 150 to the air inlet 140 is about 52°C, which is not hot to the mouth; the maximum aerosol temperature of the atomized product whose first solid carrier 20 is porous tea stem particles passing through the filtering mechanism 150 to the air inlet 140 is about 50°C, which is not hot to the mouth; the maximum aerosol temperature of the atomized product whose first solid carrier 20 is porous hydroxypropyl methylcellulose particles passing through the filtering mechanism 150 to the air inlet 140 is about 39°C, which is not hot to the mouth.

[0130] Example 7

[0131] See Figure 3:

[0132] (1) Preparation of the first solid carrier 20 and the second solid carrier 50: Referring to the method of step (1) of Example 4, the drying conditions were adjusted to prepare porous tea stem particles with a water content of 10% as the first solid carrier 20 and porous tea stem particles with a water content of 7.6% as the second solid carrier 50.

[0133] (2) Loading the functional substance 30 on the first solid carrier 20: the same as step (2) in Example 4.

[0134] (3) Loading the atomizer 40 onto the second solid carrier 50: the same as step (3) in Example 4.

[0135] (4) Preparation of atomized product and application: the same as step (4) of Example 4.

[0136] After 20 consecutive puffs of simulated suction using a suction machine (parameters set to: flow rate 18.3 mL / s, simulated inhalation for 3 seconds, and then simulated exhalation for 5 seconds), no functional substance 30 was released. Analysis showed that the collected aerosol contained a total of 0.28 mg of ketotifen, and the total release rate of ketotifen was 28%. The atomized product provided in this embodiment can achieve oral mucosal and pulmonary administration of ketotifen and can be used to prevent asthma attacks in daily use. However, due to the high water content of the first solid carrier 20, the ability of the functional substance 30 to be desorbed from the first solid carrier 20 is weakened, and the total release rate has decreased.

[0137] According to an infrared thermometer test, the maximum temperature of the aerosol passing through the filter mechanism 150 to the air inlet 140 is about 40° C., which is not hot to the mouth.

[0138] Example 8

[0139] See Figure 3:

[0140] (1) Preparation of the first solid carrier 20 and the second solid carrier 50: Referring to the method of step (1) of Example 4, the drying conditions were adjusted to prepare porous tea stem particles with a water content of 10% as the second solid carrier 50 and porous tea stem particles with a water content of 7.6% as the first solid carrier 20.

[0141] (2) Loading the functional substance 30 on the first solid carrier 20: the same as step (2) in Example 4.

[0142] (3) Loading the atomizer 40 onto the second solid carrier 50: the same as step (3) in Example 4.

[0143] (4) Preparation of atomized product and application: the same as step (4) of Example 4.

[0144] After 20 consecutive puffs, no functional substance 30 was released after simulating suction with a suction machine (parameters were set to: flow rate 18.3 mL / s, 3 seconds of simulated inhalation, followed by 5 seconds of simulated exhalation). Analysis showed that the collected aerosol contained a total of 0.64 mg of ketotifen, and the total release rate of ketotifen was 64%. The atomized product provided in this embodiment can achieve oral mucosal and pulmonary administration of ketotifen and can be used to prevent the onset of asthma in daily use. However, due to the high water content of the first solid carrier 20, the ability of the functional substance 30 to be desorbed from the first solid carrier 20 is weakened, and the total release rate has decreased.

[0145] According to the test of the infrared thermometer, the aerosol temperature passing through the filter mechanism 150 to the air inlet 140 is as high as 44°C, which is slightly hot to the mouth.

[0146] Comparative Example 1

[0147] Comparative Example 1 is a comparative example of Example 4, except that no isolation mechanism is provided in the atomizer, and both the functional substance and the atomizer are loaded on the second solid carrier and placed in the first cavity.

[0148] See Figure 4:

[0149] (1) Preparation of the second solid carrier 50: the same as step (1) of Example 4.

[0150] (2) Loading the functional substance 30 and the atomizer 40 on the second solid carrier 50: 10 g of the porous tea stem particles prepared in step (1) are placed in a mixer, and 1 g of a hot ethanol solution containing 1% ketotifen is sprayed onto the porous tea stem particles in batches while stirring. Stirring is continued in the mixer at 50° C. for half an hour to remove the ethanol, and then 10 g of glycerol is sprayed onto the porous tea stem particles in batches while stirring at 60° C. to prepare a second solid carrier 50 loaded with the functional substance 30 and the atomizer 40 (the loading amount of ketotifen is about 0.05%, and the loading amount of the glycerol atomizer is about 50%).

[0151] (3) Preparing and applying an atomized product: providing an atomizer 10, the atomizer 10 comprising a first cavity 120, a filter mechanism 150 being provided at one end of the first cavity 120, and an air inlet 140 being provided on the filter mechanism 150. Adding the second solid carrier 50 loaded with the functional substance 30 and the atomizer 40 prepared in step (2) into the first cavity 120 of the atomizer 10, heating the first cavity 120 with an external heat source so that the glycerin in the second solid carrier 50 loaded with the functional substance 30 and the atomizer 40 reaches an atomization temperature to form an atomizer aerosol, inhaling air from the air inlet 140, and the atomizer aerosol is sucked out. During the aspiration process, the atomizer aerosol contacts the functional substance 30, causing ketotifen to dissociate from the second solid carrier 50 and carry out the ketotifen to form an aerosol carrying the functional substance, which is discharged from the air inlet 140.

[0152] After 23 consecutive puffs using a simulated suction machine (parameter settings: flow rate 18.3 mL / s, simulated inhalation for 3 seconds, followed by simulated exhalation for 5 seconds), no further functional substance 30 was released. Analysis revealed that the collected aerosol contained a total of 2.8 mg of ketotifen, with a total ketotifen release rate of 28%. This indicates that the process of atomizing the aerosol by the nebulizer 40 also directly heats the functional substance 30, causing it to deteriorate and significantly reducing its release rate.

[0153] According to the test of infrared thermometer, the highest temperature of aerosol passing through the filter mechanism 220 to the air inlet 230 is 47°C, and the artificial inhalation test obviously burns the mouth.

[0154] Comparative Example 2

[0155] Comparative Example 1 is a comparative example of Example 4, except that: no isolation mechanism is provided in the atomizer, and the first solid carrier loaded with the functional substance and the second solid carrier loaded with the atomizer are both placed in the first cavity.

[0156] See Figure 5:

[0157] (1) Preparation of the first solid carrier 20 and the second solid carrier 50: the same as step (1) of Example 4.

[0158] (2) Loading the functional substance 30 on the first solid carrier 20: the same as step (2) of Example 4.

[0159] (3) Loading the atomizer 40 onto the second solid carrier 50: the same as step (3) of Example 4.

[0160] (4) Preparing and applying the atomized product: providing an atomizer 10 , the atomizer 10 comprising a first cavity 120 , a filter mechanism 150 being provided at one end of the first cavity 120 , and an air inlet 140 being provided on the filter mechanism 150 . The second solid carrier 50 loaded with the atomizer 40 prepared in step (3) is added into the first cavity 120 of the nebulizer 10, and 0.1 g of the first solid carrier 20 loaded with the functional substance 30 prepared in step (2) is added into the first cavity 120 of the nebulizer 10. The first cavity 120 is heated by an external heat source so that the glycerol in the second solid carrier 50 loaded with the atomizer 40 reaches an atomization temperature to form an atomizer aerosol. Inhalation is performed from the air inlet 140, and the atomizer aerosol is sucked out. During the aspiration process, the atomizer aerosol contacts the first solid carrier 20 loaded with the functional substance 30, so that ketotifen and sweet orange essential oil are dissociated from the first solid carrier 20, and the ketotifen and sweet orange essential oil are carried out to form an aerosol carrying the functional substance. The aerosol carrying the functional substance is discharged from the air inlet 140.

[0161] Through suction machine simulation suction (parameter setting is: flow velocity 18.3mL / s, continues 3s simulation to inhale, simulates exhale 5s afterwards), after continuous suction 20 times, no longer have functional substance 30 to release.After analysis, in the aerosol collected, amount to the ketotifen containing 0.041mg, the ketotifen total release rate is 41%.As seen, in the process that atomizer 40 is atomized into aerosol, directly functional substance 30 is carried out high-temperature heating, part functional substance 30 can be deteriorated, thereby the release rate of functional substance 30 is reduced, but, because functional substance 30 is loaded on the first solid carrier 20, not directly loaded on the second solid carrier 50, the first solid carrier 20 has certain fluidity in the first cavity 120, relative to comparative example 1, the degree that functional substance 30 is deteriorated by high temperature influence weakens, so release rate is slightly higher than comparative example 1.But generally, because functional substance 30 still has the risk of high-temperature deterioration, significantly affects the release stability of functional substance 30.

[0162] According to the test of infrared thermometer, the highest temperature of aerosol passing through the filter mechanism 220 to the air inlet 230 is 53°C, and the artificial inhalation test obviously burns the mouth.

[0163] Comparative Example 3

[0164] Comparative Example 3 is a comparative example of Example 5, except that: the second solid carrier loaded with the atomizer is added into the first cavity, and the first solid carrier loaded with the functional substance is not added into the second cavity.

[0165] See Figure 6:

[0166] (1) Preparation of the second solid carrier 50: the same as step (1) of Example 5.

[0167] (2) Loading the atomizer 40 onto the second solid carrier 50: the same as step (3) of Example 5.

[0168] (4) Preparing and applying an atomized product: providing an atomizer 10, the atomizer 10 comprising a first cavity 120 and a second cavity 130 separated by an isolation mechanism 110, the second cavity 130 being provided with a filter mechanism 150 in a direction away from the isolation mechanism 110, and an air inlet 140 being provided on the filter mechanism 150. The second solid carrier 50 loaded with the atomizer 40 prepared in step (3) is added into the first cavity 120 of the atomizer 10, and the first cavity 120 is heated by an external heat source, so that the atomizer 40 in the second solid carrier 50 reaches an atomization temperature to form an atomizer aerosol, and air is inhaled from the air inlet 140, and the atomizer aerosol is discharged from the air inlet 140.

[0169] According to the test of infrared thermometer, the highest temperature of aerosol passing through the filter mechanism 150 to the air inlet 140 is 51°C, and the artificial inhalation test obviously burns the mouth.

[0170] In this disclosure, unless otherwise expressly specified or limited, terms such as "disposed (provided with)" and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integration; mechanical connections, electrical connections; direct connections, or indirect connections through an intermediate medium; and internal connections between two elements or interactions between two elements. Those skilled in the art will understand the specific meanings of the above terms in this disclosure based on specific circumstances.

[0171] In the description of this specification, reference to the term "some embodiments" or the like means that the specific features, structures, materials, or characteristics described in conjunction with the embodiment are included in at least one embodiment of the present disclosure. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in any suitable manner in any one or more embodiments or examples. In addition, those skilled in the art may combine and combine different embodiments or examples described in this specification, as well as features of different embodiments or examples, unless they are mutually inconsistent.

[0172] Although the embodiments of the present disclosure have been shown and described above, it is understood that the above embodiments are illustrative and cannot be understood as limitations on the present disclosure. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present disclosure. Therefore, any changes or modifications made in accordance with the claims and description of the present disclosure shall fall within the scope of the patent of the present disclosure.

Claims

1. An atomization product, characterized in that: include: Nebulizers, functional substances and nebulizers; The atomizer can generate an atomizer aerosol after atomization; The atomizer comprises a first cavity and a second cavity separated by an isolation mechanism, the atomizer is loaded in the first cavity, the functional substance is loaded in the second cavity, and the isolation mechanism confines the atomizer in the first cavity; The second cavity is also provided with an air inlet, and the aerosol of the atomizer passes through the isolation mechanism from the first cavity into the second cavity and contacts with the functional substance to form an aerosol carrying the functional substance, and the aerosol carrying the functional substance is discharged from the air inlet.

2. The atomization product according to claim 1, characterized in that: The atomizer includes an inert liquid that can be atomized to form an aerosol.

3. The atomization product according to claim 1, characterized in that: The atomization temperature of the atomizer is ≤250°C.

4. The atomization product according to claim 1, characterized in that: The atomizer includes one or more of water, propylene glycol, glycerin, limonene and glyceride substances.

5. The atomization product according to claim 4, characterized in that: The glyceride substances include one or more of triacetin and caprylic decanoic acid glyceride.

6. The atomization product according to claim 1, characterized in that: The functional substance includes at least one of a substance having biological activity and a substance having sensory properties.

7. The atomization product according to claim 1, characterized in that: The biologically active substance includes one or more of ketotifen, rimantadine and nicotine.

8. The atomization product according to claim 1, characterized in that: The substance with organoleptic properties includes one or more of essence, essential oil, cooling agent and sweetener.

9. The atomization product according to claim 1, characterized in that: The second cavity is also loaded with a first solid carrier, and the functional substance is loaded on the first solid carrier.

10. The atomization product according to claim 1 or 9, characterized in that: The loading amount of the functional substance is ≥0.05%.

11. The atomization product according to claim 9, characterized in that: The first cavity is also loaded with a second solid carrier, and the atomizer is loaded on the second solid carrier.

12. The atomization product according to claim 1 or 11, characterized in that: The loading amount of the atomizer is ≥20%.

13. The atomization product according to claim 11, characterized in that: The first solid support and the second solid support are each independently selected from porous materials having physical adsorption capabilities.

14. The atomized product according to claim 13, characterized in that: The water content of the porous material with physical adsorption capacity is ≤8%.

15. The atomized product according to claim 13, characterized in that: The chemical components of the porous material with physical adsorption capacity include one or more of starch and cellulose.

16. The atomized product according to claim 15, characterized in that ,, the cellulose includes one or more of natural plant cellulose, microcrystalline cellulose, methyl cellulose and hydroxypropyl methyl cellulose.

17. The atomized product according to claim 13, characterized in that: The method of loading the functional substance on the first solid carrier comprises the following steps: spraying a liquid containing the functional substance on the first solid carrier; The method of loading the atomizer on the second solid carrier comprises the following steps: spraying the liquid containing the atomizer on the second solid carrier.

18. The atomized product according to claim 11, characterized in that: The isolation mechanism has at least one air permeable hole, and the diameter of the air permeable hole is smaller than the diameters of the first solid carrier and the second solid carrier.

19. The atomized product according to claim 1, characterized in that: During the process in which the atomizer aerosol contacts the functional substance to form the aerosol carrying the functional substance, the temperature of the atomizer aerosol is ≤150°C.

20. The atomized product according to claim 1, characterized in that: The temperature of the aerosol carrying the functional substance discharged from the air inlet is ≤40°C.

21. A method for applying the atomized product according to any one of claims 1 to 20, characterized in that: The steps include: Atomizing the atomizer to generate the atomizer aerosol; Inhalation is performed through the inhalation port, and the atomizer aerosol passes through the isolation mechanism from the first cavity into the second cavity and contacts with the functional substance to form an aerosol carrying the functional substance, and the aerosol carrying the functional substance is discharged from the inhalation port.

22. Use of the atomized product according to any one of claims 1 to 20 in the field of medical products or in the field of tobacco.

23. A method for preparing a porous material with physical adsorption capacity, characterized in that: The method comprises the following steps: mixing the chemical components of the porous material with physical adsorption capacity with water, granulating the mixture and drying the mixture.

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