Cosmetic composition of solubilized formulation comprising bio-derived isosorbide and fermented ceramide

Abstract

The present application relates to a cosmetic composition of a solubilized formulation comprising bio-derived isosorbide and fermented ceramide. The solubilized cosmetic composition has improved formulation stability and increased solubility of ceramide in purified water, thereby having high transparency and providing excellent feeling of use to a user. Therefore, the cosmetic composition can be applied to various transparent types of solubilized cosmetics including toners and serums.

Description

Cosmetic composition of solubilized formulation containing bio-derived isosorbide and fermented ceramide

[0001] This application relates to a cosmetic composition comprising a solubilized formulation containing bio-derived isosorbide and fermented ceramide. This application claims priority to Republic of Korea Patent Application No. 10-2023-0097033, filed with the Korean Intellectual Property Office on July 25, 2023, the disclosure of which is incorporated herein by reference.

[0002] Ceramides are the main lipids that make up the lamellar structure of intercellular lipids in the skin, and are known to play an essential role in the skin's permeability barrier function. A decrease in ceramides in the skin can lead to decreased moisture content, increased moisture loss, and stratum corneum exfoliation, which can lead to a damaged or unhealthy skin barrier. These symptoms can be improved by supplying ceramides to the skin, and ceramides are utilized as effective ingredients for improving skin condition and enhancing moisturizing effects. However, ceramides are poorly soluble substances with a high tendency to crystallize. Despite their excellent efficacy, as mentioned above, their application in cosmetics is difficult due to formulation stability issues. Specifically, gelation, a phenomenon in which ceramides precipitate, frequently occurs during the formulation process. In addition, because its solubility in purified water, the most basic cosmetic ingredient, is very low, its use has been limited to cosmetic preparations with a certain degree of viscosity, such as lotions and creams, and its application to transparent, soluble cosmetics, such as toners and skins, is limited.

[0003] Meanwhile, cosmetic solubilizing formulations can be categorized into oil-in-water, water-in-oil, and aqueous dispersions. While aqueous dispersions contain only polyols and ionic components that readily dissolve in water, water-in-oil formulations encapsulate aqueous components in the oil phase, and oil-in-water formulations encapsulate oil components in the aqueous phase. These formulations often present challenges, such as stability over time. Consequently, many cosmetic compositions for solubilizing products utilize aqueous dispersions, meeting customer needs as products without stability issues over time. However, these solubilizing compositions, which consist solely of aqueous components, have the disadvantage of low affinity and adsorption with the skin's lipid layer. Therefore, many researchers have been developing technologies for encapsulating oil components in solubilizing formulations in the cosmetics and pharmaceutical industries. The most representative methods include chemical and physical methods. Chemical methods include a method that completely solubilizes oil components using a large amount of surfactant, but this method can cause skin irritation due to the large amount of surfactant, and can cause skin diseases such as atopy by reducing the skin barrier or skin flora.

[0004] Under this technological background, there is a need for the development of a solubilized formulation that includes ceramide, a soluble ingredient, but is transparent and has improved usability while maintaining formulation stability (Korean Patent Publication No. 2023-0050156), but this is still insufficient.

[0005] The present inventors have conducted extensive research to solve the problems of the prior art and have confirmed that by using isosorbide, the solubility of ceramide in purified water can be increased, and a transparent type of soluble cosmetic such as a toner can be manufactured, and that it can provide the user with an excellent feeling of use and an improved moisturizing sensation, and have completed the present invention based on this.

[0006] Accordingly, one aspect is to provide a cosmetic composition in the form of a solubilized formulation comprising ceramide and isosorbide.

[0007] Other purposes and advantages of this application will be further clarified by the detailed description below, taken in conjunction with the appended claims and drawings. Any details not described herein will be readily apparent and inferred by those skilled in the technical field of this application or similar technical fields, and therefore, their description will be omitted.

[0008] Each description and embodiment disclosed in this application may also be applied to each other description and embodiment. That is, all combinations of the various elements disclosed in this application fall within the scope of this application. Furthermore, the scope of this application is not limited by the specific descriptions described below.

[0009] One aspect is an oil-in-water (O / W) type cosmetic composition comprising an oil phase comprising ceramide; and an aqueous phase comprising isosorbide.

[0010] A cosmetic composition is provided, wherein the isosorbide is included in an amount of 6 to 43 wt% based on the total weight of the cosmetic composition.

[0011] As used herein, the term "isosorbide" refers to an anhydrous sugar alcohol in the form of a diol obtained by dehydration of sorbitol, a sugar alcohol having six carbon atoms. The isosorbide may be obtained naturally or artificially. For example, if it is obtained naturally, isosorbide can be synthesized through a dehydration reaction via an intermediate product of sorbitol by hydrogenating D-glucose from corn starch under a catalyst, but is not limited thereto.

[0012] As used herein, the term "ceramide" refers to an essential component for the formation of the structure or function of the stratum corneum as an intercellular lipid that fills the space between keratinocytes with N-acylsphingosine. The ceramide may include not only natural ceramide but also a substance that acts as a skin barrier, such as natural ceramide, and the ceramide may be at least one selected from the group consisting of, for example, ceramide EOP, ceramide NS, ceramide NP, ceramide AS, ceramide AP, ceramide EOS, and ceramide NDS. As the content of the ceramide increases, the skin moisturizing effect of the cosmetic composition increases and the skin may become smoother.

[0013] In one specific embodiment, the cosmetic composition may be in the form of an emulsion formulation.

[0014] As used herein, the term "emulsion" refers to a type of colloid formed by combining two immiscible liquids, for example, an oil phase and an aqueous phase, and may be used interchangeably with the term emulsion. The emulsion formulation may be an oil-in-water formulation composed of an aqueous dispersed continuous phase and an oily dispersed discontinuous phase, or a water-in-oil formulation composed of an oily dispersed continuous phase and a water-dispersed discontinuous phase. A solvent, a solubilizer, or an emulsifier may be used as a carrier component for the emulsion formulation, and may include, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol oil, aliphatic esters, polyethylene glycol, or fatty acid esters of sorbitan.

[0015] In one specific example, the isosorbide may be included in an amount of 6 to 43 wt% based on the total weight of the cosmetic composition. If the content of isosorbide is too low outside the above range, the ceramides in the composition cannot be completely dissolved, resulting in layer separation between the oil phase and the water phase. Conversely, if the content of isosorbide is excessively high, layer separation may also occur as described above. For example, the isosorbide may be included in an amount of 6 to 43 wt%, 6 to 40 wt%, 6 to 35 wt%, 6 to 30 wt%, 6 to 25 wt%, 6 to 20 wt%, 6 to 15 wt%, 6 to 10 wt%, 8 to 43 wt%, 8 to 40 wt%, 8 to 35 wt%, 8 to 30 wt%, 8 to 25 wt%, 8 to 20 wt%, 8 to 15 wt%, 8 to 10 wt%, 10 to 43 wt%, 10 to 40 wt%, 10 to 35 wt%, 10 to 30 wt%, 10 to 25 wt%, 10 to 20 wt%, or 10 to 15 wt% based on the total weight of the cosmetic composition, but is not limited thereto.

[0016] According to one embodiment, a cosmetic composition in the form of an oil-in-water emulsion was prepared by preparing an oil phase comprising ceramide and an aqueous phase comprising isosorbide, and then adding and mixing the oil phase to the aqueous phase. It was confirmed that the cosmetic composition contained isosorbide, and thus the layers of the aqueous phase and the oil phase did not separate, and crystallized ceramide did not precipitate.

[0017] In one specific example, the ceramide may be included in an amount of 2 to 8 wt% based on the total weight of the cosmetic composition. If the content of ceramide is too low outside the above range, the skin moisturizing effect may not be sufficient, and conversely, if the content of ceramide is excessively high, a gelling phenomenon in which crystallized ceramide is precipitated within the formulation may occur. For example, the ceramide may be included in an amount of 2 to 8 wt%, 2 to 7 wt%, 2 to 6 wt%, 3 to 8 wt%, 3 to 7 wt%, or 3 to 6 wt% based on the total weight of the cosmetic composition, but is not limited thereto, and the range may be appropriately changed within a range in which effective efficacy can be exhibited within the cosmetic composition.

[0018] In one specific example, the cosmetic composition may be diluted by further adding purified water and may have a solubilized formulation.

[0019] The term "solubilization formulation" used herein may refer to an oil-in-water (O / W) type composition in which the solubility of an oily ingredient is enhanced. As an example, the cosmetic composition of the solubilization formulation may be provided in the form of a transparent solubilization cosmetic, such as a toner, essence, serum, pack, ampoule, or immersion sheet mask. The solubilization formulation has the advantage of being much lighter and more refreshing, and providing an immediate moisturizing feeling. However, since ceramide is a representative poorly soluble substance, there are many limitations in producing a cosmetic of the solubilization formulation, and the gelling phenomenon in which ceramide crystallizes and precipitates acts as a factor that lowers the stability of the solubilization agent during the formulation process.

[0020] The term "solubilization" as used herein refers to the ability of a small amount of an oily component to be transparently dissolved in a large amount of an aqueous component, and for the purpose of the invention, may indicate the degree of solubility of ceramide in purified water. The solubilized formulation or formulation with increased solubility may be prepared by, but is not limited to, a method of pre-mixing a solubilizing agent and a substance to be solubilized and diluting the mixture by adding a dispersion medium, or a method of dissolving a solubilizing agent in a dispersion medium and adding a substance to be solubilized thereto.

[0021] According to one embodiment, the cosmetic composition can include a high content of ceramide while maintaining formulation stability and transparency by including isosorbide together with the useful ingredient ceramide, and can also provide the user with an excellent feeling of use and an enhanced moisturizing sensation. Therefore, the cosmetic composition according to one embodiment has increased solubility of ceramide in purified water, and can be applied to the manufacture of transparent, solubilized cosmetics such as toners.

[0022] In one specific embodiment, the ceramide may be included in an amount of 0.01 to 0.04 wt% based on the total weight of the cosmetic composition. For example, the ceramide may be included in an amount of 0.01 to 0.04 wt%, 0.01 to 0.035 wt%, 0.01 to 0.03 wt%, 0.01 to 0.025 wt%, 0.01 to 0.02 wt%, 0.01 to 0.015 wt%, 0.02 to 0.04 wt%, 0.02 to 0.035 wt%, 0.02 to 0.03 wt%, 0.02 to 0.025 wt%, 0.03 to 0.04 wt%, or 0.03 to 0.035 wt% based on the total weight of the cosmetic composition. If the ceramide content is too low outside the above range, the skin moisturizing effect may not be sufficient, and conversely, if the ceramide content is high, there is a concern that transparency may be reduced and formulation stability may be reduced.

[0023] In one specific example, the isosorbide may be included in an amount of 0.04 to 0.2 wt% based on the weight of the cosmetic composition. For example, the isosorbide may be included in an amount of 0.04 to 0.2 wt%, 0.04 to 0.15 wt%, 0.04 to 0.1 wt%, 0.1 to 0.2 wt%, 0.1 to 0.15 wt%, or 0.15 to 0.2 wt% based on the weight of the cosmetic composition. If the content of isosorbide is too low outside the above range, the ceramide in the composition may not be completely dissolved, resulting in crystallization of the ceramide, which may cause problems with transparency and formulation stability. Conversely, if the content of isosorbide is excessively high, the ceramide may precipitate.

[0024] In one specific example, a cosmetic composition may be provided comprising 0.015 to 0.03 wt% of ceramide and 0.052 to 0.16 wt% of isosorbide based on the total weight of the cosmetic composition. If the content of isosorbide is too low or too high relative to ceramide outside the above range, the effect of promoting the solubility of ceramide in purified water may be inhibited, thereby reducing formulation stability and transparency, which may result in a deterioration of the user's feeling of use.

[0025] In one specific example, the cosmetic composition may be prepared by diluting an oil-in-water emulsifier containing an aqueous phase containing isosorbide and an emulsifier, and an oil phase containing ceramide, with purified water.

[0026] As used herein, the term “emulsifier” may mean a substance that can form a stable emulsion of two liquids that do not mix with each other. The above emulsifier may be used without limitation as long as it is an emulsifier commonly used in the manufacture of a cosmetic composition, and examples thereof include behentrimonium chloride, behentrimonium methosulfate, cyclopentasiloxane, glycol stearate, sorbitan sesquioleate, glyceryl oleate, glycol distearate, propylene glycol monostearate, glyceryl stearate, sorbitan stearate, polyglyceryl-2 triisostearate, polyglyceryl-3 diisostearate, polyglyceryl-2 isostearate, polyglyceryl-2 oleate, polyglyceryl-2 caprate, polyglyceryl-10 oleate, polyglyceryl-10 laurate, PEG-18 glyceryl oleate / cocoate, PEG-120 methyl glucose dioleate, PEG-10 dimethicone, It may be at least one selected from the group consisting of lauryl PEG-10 tris(trimethylsiloxy)silyl ethyl dimethicone, cetyl PEG / PPG-10 / 1 dimethicone, ceteareth-12, cetearimonium chloride, stearyl alcohol, stearimonium chloride, lauryl trimonium chloride, soyamidopropylamine oxide, tolamide DEA, potassium cetyl phosphate, polysorbate 60, sorbitan olivate, inulin lauryl carbamate, lecithin, arachidyl glucoside, olive oil PEG-8 esters, and sucrose fatty acid esters.

[0027] In one specific embodiment, the emulsifier may be included in an amount of 0.001 to 0.1 wt% based on the total weight of the cosmetic composition. For example, the emulsifier may be included in an amount of 0.001 to 0.1 wt%, 0.001 to 0.05 wt%, 0.001 to 0.01 wt%, 0.001 to 0.005 wt%, 0.005 to 0.1 wt%, 0.005 to 0.05 wt%, 0.005 to 0.01 wt%, 0.01 to 0.1 wt%, or 0.01 to 0.05 wt% based on the total weight of the cosmetic composition, but is not limited thereto.

[0028] In one specific embodiment, the cosmetic composition may further comprise one or more selected from the group consisting of a polyol moisturizer, an oil, and a surfactant.

[0029] The above "polyol moisturizer" may include at least one selected from the group consisting of polyethylene glycol, sorbitol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, methylpropanediol, and mantitol.

[0030] The above "oil" may be a silicone oil, an ester oil, a triglyceride oil, a hydrocarbon oil, or a vegetable oil, and one or more of these components may be combined and used as needed. For example, the silicone oil may be a silicone fluid oil or a silicone crosspolymer dispersed in oil. For example, silicone-based fluid oils that can be used include cyclopentasiloxane, cyclohexasiloxane, cycloheptasiloxane, cyclomethicone, cyclophenylmethicone, cyclotetrasiloxane, cyclotrisiloxane, dimethicone, capryl dimethicone, caprylyl trimethicone, caprylyl methicone, cetearyl methicone, hexadecyl methicone, hexyl methicone, lauryl methicone, myristyl methicone, phenyl methicone, stearyl methicone, stearyl dimethicone, trifluoropropyl methicone, cetyl dimethicone, diphenylsiloxyphenyl trimethicone, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methyl trimethicone, or phenyl trimethicone. The above silicone-based oil components can be used alone or in combination of two or more types of oil. Silicone-based crosspolymers include, but are not limited to, dimethicone crosspolymer, dimethicone / vinyl dimethicone crosspolymer, dimethicone PEG-10 / 15 crosspolymer, or PEG-12 dimethicone / PPG-20 crosspolymer.Ester oils include ascorbyl palmitate, ascorbilinoleate, ascorbyl stearate, diisostearyl malate, benzyl benzoate, benzyl laurate, butylene glycol dicaprylate / dicaprate, butylene glycol diisononanoate, butylene glycol aurate, butylene glycol stearate, butyl isostearate, cetearyl isononanoate, cetyl nonanoate, cetyl caprylate, cetyl ethylhexanoate, cetyl isononanoate, ethylhexyl caprylate / caprate, ethylhexyl isononanoate, ethylhexyl isostearate, ethylhexyl laurate, hexyl laurate, octyldodecyl isostearate, isopropyl isostearate, isostearyl Isononanoate, Isostearyl Isostearate, Isocetyl Ethylhexanoate, Neopentyl Glycol Dicaprate, Neopentyl Glycol Diethylhexanoate, Neopentyl Glycol Diisononanoate, Neopentyl Glycol Diisostearate, Pentaerythrityl Stearate, Pentaerythrityl Tetraethylhexanoate, Dipentaerythrityl Hexaacid Ester, Polyglyceryl-2 Diisostearate, Polyglyceryl-2 Diisostearate, Polyglyceryl-2 Sesquiisostearate, Polyglyceryl-2 Isostearate, Polyglyceryl-2 Isostearate, Polyglyceryl-2 Tetraisostearate, Polyglyceryl-2 Triisostearate, Polyglyceryl-3 Diisostearate, Polyglyceryl-3 isostearate, polyglyceryl-4 diisostearate, polyglyceryl-4 isostearate, polyglyceryl-6 diisostearate, polyglyceryl-6 sesquiisostearate, or triethylhexanoin can be used.Examples of the triglyceride oil include C8-C12 acid triglyceride, C12-C18 acid triglyceride, caprylic / capric triglyceride, caprylic / capric / lauric triglyceride, C10-C40 isoalkyl acid triglyceride, C10-C18 triglyceride, glyceryl triacetyl hydrostearate, soybean glyceride, tribehenin, tricaprin, triethylhexanoin, triheptanoin, triisostearin, tripalmitin, or tristearin. Examples of the hydrocarbon oil include liquid paraffin (liquid paraffin, mineral oil), paraffin, petrolatum, microcrystalline wax, or squalene. The above vegetable oils may include avocado oil, wheat germ oil, rosehip oil, shea butter, almond oil, olive oil, macadamia oil, argan oil, meadowfoam oil, sunflower oil, castor oil, camellia oil, corn oil, safflower oil, soybean oil, rapeseed oil, macadamia nut oil, jojoba oil, palm oil, palm kernel oil, or coconut oil.

[0031] The surfactant may be a natural surfactant or a synthetic surfactant. Specifically, the natural surfactant may include at least one surfactant selected from the group consisting of soybean lecithin, egg lecithin, hydrogenated lecithin (hydrogenated soybean lecithin and hydrogenated egg lecithin), sphingosine, ganglioside, and phytosphingosine, but is not limited thereto. Here, the surfactant may be included in an amount of 0.01 to 0.1 wt% based on the total weight of the cosmetic composition.

[0032] It was confirmed that a cosmetic composition according to one embodiment has high transparency by increasing the solubility of ceramide in purified water even when a small amount of surfactant is added.

[0033] In addition, the cosmetic composition may further comprise any conventional cosmetic ingredient selected from additional ingredients commonly used in cosmetics, such as thickeners, dispersants, fragrances, fillers, preservatives, antiseptics, neutralizers, sweeteners, vitamins, free-radical scavengers, metal ion sequestering agents, functional ingredients, and mixtures thereof.

[0034] Another aspect provides a composition for external application to the skin comprising isosorbide and ceramide.

[0035] In the above skin external preparation composition, the same elements among the mentioned terminology as those already mentioned are as described above.

[0036] In this specification, the term "skin external preparation" is a concept that generally encompasses all compositions used for external use, and can be broadly applied to various cosmetic compositions including various cosmetics such as base cosmetics, makeup cosmetics, hair cosmetics, and shaving cosmetics, as well as various pharmaceuticals and quasi-drugs such as ointments.

[0037] The above-mentioned external preparation for skin may be a cream, gel, ointment, skin emulsifier, skin suspension, transdermal patch, drug-containing bandage, lotion, or a combination thereof. The above-mentioned external preparation for skin may be appropriately mixed with ingredients commonly used in external preparations for skin such as cosmetics or medicines, such as aqueous ingredients, oily ingredients, powder ingredients, alcohols, moisturizers, thickeners, UV absorbers, whitening agents, preservatives, antioxidants, surfactants, fragrances, colorants, various skin nutrients, or a combination thereof, as needed. The above skin external preparation may also appropriately contain metal sequestrants such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, and gluconic acid; caffeine, tannin, bellapamil, glabridin, various herbal medicines, tocopheryl acetate, glycyrrhizic acid, tranexamic acid and derivatives or salts thereof; and sugars such as vitamin C, arbutin, kojic acid, glucose, fructose, and trehalose.

[0038] Another aspect provides a method for improving skin condition, comprising the step of applying a composition comprising isosorbide and ceramide to the skin of a subject.

[0039] In the above method, the same terms or elements mentioned above as those already mentioned are as described above.

[0040] As used herein, the term "subject" means a subject in need of improvement of skin condition, and more specifically, a mammal such as a human or non-human primate, mouse, dog, cat, horse, and cow.

[0041] As used herein, the terms "applying," "administering," and "distributing" are used interchangeably and may mean causing at least partial localization of a composition according to one embodiment to a desired site, or disposing a composition according to one embodiment into a subject by an administration route.

[0042] In this specification, the term "improvement of skin condition" may mean any action that promotes the skin barrier function and promotes the differentiation of keratinocytes by effectively influencing keratinocytes by supplying the active ingredient ceramide to the skin, and may be, for example, improvement of skin aging, skin moisturizing, skin barrier strengthening, wrinkle improvement, or skin soothing.

[0043] As used herein, the term "improvement" may mean any action that at least reduces the severity of a symptom, for example, a parameter associated with alleviating or treating a condition.

[0044] As used herein, the term "skin aging" refers to the tangible and intangible changes that occur in the skin with age. The term "preventing or improving skin aging" may refer to inhibiting or delaying skin aging, regardless of the cause.

[0045] As used herein, the term "skin moisturizing" may mean any action that maintains skin moisture or prevents moisture loss.

[0046] As used herein, the term "skin soothing" means that skin troubles such as inflammation, stinging, itching, erythema, swelling, astringency, and pore constriction are alleviated or prevented due to various possible physical and chemical irritants.

[0047] As used herein, the term "skin barrier strengthening" can refer to any action that enhances the function of the skin barrier, located at the outermost layer of the skin and preventing moisture and nutrient loss. Damage to skin barrier function can refer to any change that occurs in the skin due to a decline or damage to the skin barrier function.

[0048] As used herein, the term "improving skin wrinkles" or "increasing skin elasticity" may mean alleviating the degree to which skin sags or sags, or inhibiting or preventing the formation of wrinkles on the skin, or alleviating wrinkles that have already formed.

[0049] According to a cosmetic composition according to an aspect, by including isosorbide, the formulation stability of ceramide is improved and the solubility of ceramide in purified water is increased, thereby providing high transparency and an excellent feeling of use to the user.

[0050] Figure 1 shows the results of visually confirming the stability of the formulation of Example 1.

[0051] Figure 2 shows the results of visually confirming the stability of the formulation of Comparative Example 1 that does not contain isosorbide.

[0052] Figure 3 shows the results of visually confirming the formulation stability and transparency of Example 1.

[0053] Figure 4 shows the results of visually confirming the stability and transparency of the formulation of Example 2 containing a high content of ceramide.

[0054] Figure 5 shows the results of visually confirming the formulation stability and transparency of Example 3.

[0055] Figure 6 shows the results of visually confirming the formulation stability and transparency of Example 5.

[0056] Figure 7 shows the results of visually confirming the formulation stability of Comparative Example 2.

[0057] Figure 8 shows the results of visually confirming the formulation stability and transparency of Comparative Example 3.

[0058] Figure 9 shows the results of visually confirming the formulation stability and transparency of Comparative Example 4.

[0059] Hereinafter, preferred examples are presented to aid in understanding the present invention. However, the following examples are provided solely to facilitate a better understanding of the present invention, and the scope of the present invention is not limited by the following examples.

[0060]

[0061] Examples 1 to 5. Preparation of a cosmetic composition of a solubilized formulation containing ceramide

[0062] A cosmetic composition in the form of a solubilized formulation containing isosorbide and ceramide was prepared. Specifically, an oil-in-water (O / W) type emulsifying raw material was prepared by mixing an aqueous phase and an oil phase, and then an appropriate amount of purified water was added thereto to prepare a cosmetic composition in the form of a solubilized formulation.

[0063] The components and contents of each of the water and oil phases are as shown in Table 1 below. In addition, the isosorbide (NOVASORB®) was obtained from Samyang Innochem and used (purity 99.8%, pH 5.6).

[0064] [Table 1]

[0065]

[0066] Specifically, an appropriate amount of purified water and a polyol moisturizer were added to isosorbide, stirred while heating to 75℃, and Ethylenediaminetetraacetic Acid, trisodium Salt (EDTA 3Na) was mixed and dissolved therein to prepare an aqueous phase. Meanwhile, oil, lecithin, ceramide, and a preservative were mixed, stirred, and dissolved while heating to separately prepare an oil phase. Thereafter, the prepared oil phase was added to the aqueous phase, emulsified using a homogenizer at 4,500 rpm for 5 minutes, and homogenized three times under the condition of 1,000 bar using a microfluidizer, thereby preparing an oil-in-water emulsified raw material containing ceramide and isosorbide.

[0067] Thereafter, the above-mentioned water-in-oil emulsifying raw material was diluted to 0.5% with purified water to prepare a cosmetic composition in the form of a solubilized formulation having the ingredients and contents of Table 2.

[0068] [Table 2]

[0069]

[0070]

[0071] Comparative Example 1. Preparation of a cosmetic composition not containing isosorbide

[0072] A cosmetic composition was prepared that does not contain isosorbide. In the oil-in-water emulsifying raw material for preparing the cosmetic composition, the components and contents of each of the water phase and oil phase are as shown in Table 3 below, and a cosmetic composition having the components and contents of Table 4 was prepared in the same manner as in Examples 1 to 5.

[0073] [Table 3]

[0074]

[0075] [Table 4]

[0076]

[0077]

[0078] Comparative Examples 2 to 4. Preparation of cosmetic compositions containing isosorbide in various amounts

[0079] Cosmetic compositions containing isosorbide in various amounts were prepared. In the oil-in-water emulsifying raw materials for preparing the cosmetic compositions, the components and contents of each of the water phase and oil phase are as shown in Table 5 below, and cosmetic compositions having the components and contents of Table 6 were prepared in the same manner as in Examples 1 to 5.

[0080] [Table 5]

[0081]

[0082] [Table 6]

[0083]

[0084]

[0085] Experimental Example 1. Stability of the solubilized formulation with or without isosorbide

[0086] In this experimental example, the effect of isosorbide on the stability of solubilized formulations was investigated. To this end, the stability of cosmetic compositions manufactured using the oil-in-water emulsifier raw materials of Example 1 and Comparative Example 1 as solubilized formulations was visually evaluated.

[0087] Fig. 1 shows the results of visual inspection of the cosmetic composition of Example 1, and Fig. 2 shows the results of visual inspection of the cosmetic composition of Comparative Example 1 that does not contain isosorbide. As a result, as shown in Figs. 1 and 2, in the cosmetic composition according to one embodiment, ceramide crystals were not precipitated, and thus, it was confirmed that it can be applied as a solubilized formulation. On the other hand, in the case of Comparative Example 1 that does not contain isosorbide, the phenomenon of ceramide, which is a poorly soluble substance, crystallizing in the oil-in-water emulsifying raw material progressed, and therefore, it was confirmed that there is a limit to applying it as a solubilized formulation in the cosmetic composition.

[0088]

[0089] Experimental Example 2. Confirmation of Formulation Stability According to Isosorbide Content

[0090] In this experimental example, the effect of the isosorbide content level on the formulation stability of a cosmetic composition was examined. To this end, the formation of a solubilized formulation and the transparency or turbidity level of the cosmetic compositions of Examples 1 to 5 and Comparative Examples 2 to 4 having different isosorbide contents were evaluated. Here, the transparency or turbidity level was evaluated by transferring each cosmetic composition to a transparent container, placing the transparent container on a plate printed with letters or lines, and visually checking the letters or lines reflected through the manufactured cosmetic composition.

[0091] Figures 3 to 6 are the results of visual inspection of the cosmetic compositions of Examples 1 to 3 and Example 5, and Figures 7 to 9 are the results of visual inspection of the cosmetic compositions of Comparative Examples 2 to 4 containing isosorbide having various contents.

[0092] As a result, as shown in FIGS. 3 to 6, it was confirmed that the cosmetic composition according to one embodiment is a highly transparent solubilizing agent, and that the stability of the formulation is maintained even when a high content of ceramide is included. On the other hand, as shown in FIGS. 7 to 9, when the content of isosorbide is excessively low or high, a layer separation phenomenon occurs, or, as in Comparative Example 1, ceramide crystallizes, resulting in a decrease in formulation stability or a significant decrease in transparency, which limits its application to products such as skin, toner, and lotion. The above experimental results indicate that the stability and transparency level as a solubilizing formulation can be achieved by isosorbide in a specific content range.

[0093]

[0094] Experimental Example 3. Usability Evaluation

[0095] In this experimental example, the effect of isosorbide on improving the usability of a cosmetic composition was investigated. To this end, a total of 15 adults were selected as test subjects, and the cosmetic composition (skin) shown in Table 7 below was applied to the back of the hand. The usability was measured using a 5-point preference scale (5: very good, 4: good, 3: average, 2: bad, 1: very bad) for a total of 5 items: moisture, spreadability, oiliness, stickiness, and residual feeling. The average value for each item was calculated, and the results are shown in Table 8 below.

[0096] [Table 7]

[0097]

[0098] [Table 8]

[0099]

[0100] As a result, as shown in Table 8 above, the ceramide skin containing isosorbide had improved moisture, spreadability, and residual feeling compared to the skin not containing isosorbide, while the stickiness that has a negative impact on the user was reduced. In particular, it was confirmed that the moisture and spreadability that provide a light, refreshing, and immediate moisturizing feeling, which are characteristics of a solubilized formulation, were significantly improved. The above experimental results indicate that the cosmetic composition according to one embodiment can improve the usability and usability as a moisturizing cosmetic composition by including isosorbide.

[0101] In summary of the above results, a cosmetic composition of a solubilized formulation according to one embodiment including isosorbide can contain a high content of ceramide while maintaining formulation stability and high transparency, and can provide a user with an excellent feeling of use and an enhanced feeling of moisture retention, thereby improving its utility as a cosmetic composition such as a skin, and in particular, as a moisturizing cosmetic.

[0102] The foregoing description of the present invention is provided for illustrative purposes only. Those skilled in the art will readily appreciate that the present invention can be readily modified into other specific forms without altering the technical spirit or essential characteristics of the present invention. Therefore, the embodiments described above should be understood as illustrative in all respects and not restrictive.

Claims

1. An oil-in-water (O / W) type cosmetic composition comprising an oil phase comprising ceramide and an aqueous phase comprising isosorbide, A cosmetic composition, wherein the isosorbide is contained in an amount of 6 to 43 wt% based on the total weight of the cosmetic composition.

2. A cosmetic composition according to claim 1, wherein the cosmetic composition is in an emulsion formulation.

3. A cosmetic composition according to claim 1, wherein the ceramide is contained in an amount of 2 to 8 wt% based on the total weight of the cosmetic composition.

4. In claim 1, the cosmetic composition is diluted by further adding purified water, and has a solubilized formulation.

5. A cosmetic composition according to claim 4, wherein the isosorbide is contained in an amount of 0.04 to 0.2 wt% based on the total weight of the cosmetic composition.

6. In claim 4, the cosmetic composition has increased solubility of ceramide in purified water.

7. A cosmetic composition according to claim 4, wherein the ceramide is at least one selected from the group consisting of ceramide EOP, ceramide NS, ceramide NP, ceramide AS, ceramide AP, ceramide EOS, and ceramide NDS.

8. A cosmetic composition according to claim 4, wherein the ceramide is contained in an amount of 0.01 to 0.04 wt% based on the total weight of the cosmetic composition.

9. A cosmetic composition according to claim 4, comprising 0.015 to 0.03 wt% of ceramide and 0.052 to 0.16 wt% of isosorbide based on the total weight of the cosmetic composition.

10. A cosmetic composition according to claim 4, wherein the cosmetic composition further comprises at least one selected from the group consisting of a polyol moisturizer, an oil, and a surfactant.

11. A cosmetic composition according to claim 9, wherein the surfactant is contained in an amount of 0.01 to 0.1 wt% based on the total weight of the cosmetic composition.

12. A cosmetic composition according to claim 1, wherein the cosmetic composition is a toner, essence, serum, pack, ampoule or immersion sheet mask.

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