Additive based on fluorinated carbamate prepolymer, and preparation and use thereof in preparation of medical fluorinated anticoagulant polyurethane material

By blending additives based on fluorine-containing urethane prepolymer with commercial polyurethane masterbatch, medical fluorine-containing anticoagulant polyurethane materials are prepared, which solves the problem that existing medical polyurethane materials are prone to coagulation during blood contact, and achieves efficient and low-cost anticoagulant performance improvement, and maintains the excellent mechanical properties of the material.

WO2025081842A1 Publication Date: 2025-04-24GUANGZHOU MEDICAL UNIV
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Patent Information

Application Number
PCT/CN2024/096953
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-10-18
Filing Date
2024-06-03
Publication Date
2025-04-24

AI Technical Summary

Technical Problem

Existing medical polyurethane materials are prone to coagulation during blood contact, and when the anticoagulation performance is improved by chemical modification, the batch preparation repeatability, stability and cost of materials are problematic.

Method used

A high fluorine-containing small molecule diol is synthesized through a simple process using additives based on fluorine-containing urethane prepolymers, and a high fluorine-containing urethane prepolymer additive is prepared by using it as a chain extender and a monohydric alcohol containing fluorine-containing carbon chain as a capping agent. The additive is blended with commercial polyurethane masterbatch to prepare medical fluorine-containing anticoagulant polyurethane materials.

Benefits of technology

Through the use of low molecular weight polyurethane additives, the material has low surface energy and is enriched with fluorine atoms, which significantly reduces the adhesion of plasma proteins, cells and platelets, and achieves excellent anticoagulation effects. At the same time, due to the high fluorine content of the additive, it only requires a lower amount of addition to achieve excellent anticoagulation performance and effectively reduces the impact on the mechanical properties of the material.

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Abstract

A type of additive based on a fluorinated carbamate prepolymer, a preparation method therefor, and a use thereof in the preparation of a medical fluorinated anticoagulant polyurethane material. The preparation method of the additive comprises: reacting a polyester / polyether diol, a diisocyanate and a fluorinated small-molecule diol, to obtain a carbamate prepolymer having an isocyanate end group, and then capping with a monohydric alcohol having a fluorinated carbon chain, to obtain an additive based on a fluorinated carbamate prepolymer. The additive has a high fluorine content. After being blended with a polyurethane masterbatch, fluorine atoms having low surface energy can be enriched on the surface of the material, and the fluorine atom content on the surface of the material can be as high as 60%. This effectively reduces the adhesion of plasma proteins, cells and platelets on the surface of the material, providing the medical polyurethane material with an excellent anticoagulant effect. In addition, it maintains the excellent mechanical properties of polyurethane, and is thus widely applicable in the preparation of medical fluorinated anticoagulant polyurethane materials.
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