A medicament delivery device and cassettes comprising colored labels

Abstract

A medicament delivery device (1, 1') comprising: at least two disposable cassettes (4, 4a, 4b, 4c, 4d), each disposable cassette (4, 4a, 4b, 4c, 4d) containing a medicament and comprising a colored label (5, 5a, 5b, 5c, 5d); a drive unit (3) comprising: a receiving interface (10, 110) adapted to receive the disposable cassettes (4, 4a, 4b, 4c, 4d) one after the other according to a receiving order; a power module (8) configured to act on the received disposable cassette (4, 4a, 4b, 4c, 4d) to expel the medicament; a light emitter (20, 120) configured to emit a colored light in the visible spectrum, and a control unit (85) provided with a predetermined color sequence corresponding to the receiving order of the disposable cassettes (4, 4a, 4b, 4c, 4d) in the receiving interface (10, 110) based on the colors of the colored labels (5, 5a, 5b, 5c, 5d).

Description

[0001] A MEDICAMENT DELIVERY DEVICE AND CASSETTES COMPRISING COLORED LABELS

[0002] TECHNICAL FIELD

[0003] The present disclosure generally relates to medical devices for medicament administration.

[0004] BACKGROUND

[0005] A number of medical conditions require injections. These days, a number of different injection devices exist, including various types of pen injectors, autoinjectors and on-body devices. Although many of these devices have enabled major improvements in the management of a number of medical conditions, various limitations do still exist in the current technology.

[0006] Some medicament delivery devices are designed to deliver multiple medications, e.g. to deliver a regimen comprising sequenced medicament administrations. That is, a series of medications given back-to-back with a specified order of administration. For medicament delivery devices which can only administer one medicament container at a time, a user must apply a sequenced workflow and correctly connect and administer a first medicament container, remove the first medicament container, connect and administer a second medicament container, and so on. This type of sequenced regimen must be communicated to users.

[0007] For regimens in which the order of administration of the various medicament containers is of consequence, the ordinal position of each medicament container in the regimen can be defined by a receiving order for which the drive unit of the medicament delivery device is to receive (and subsequently administer) the medicament containers. Moreover, the regimen length, i.e. the total number of medicament containers in the regimen may be communicated to the user.

[0008] However, communicating a regimen comprising sequenced medicament administrations on a generic level is non-trivial when medication regimens vary between patients. One primary complexity is that the number of medications in a given patient’s regimen is not always known a priori and may vary from one dosing instance to another. In some use cases, one patient may undergo changes in regimen throughout the lifespan of their drive unit (e.g., rapidly changing care guidelines in oncology, unpredictably fluctuating laboratory values, or different medications administered at each dosing interval, such as on day 7, 14, or 21). As such, the drive unit cannot know the correct regimen information to communicate a priori.

[0009] In considering these problems, the applicant has appreciated that various developments could be made to help improve the medicament delivery devices on the market today, which are set out in more detail below.

[0010] SUMMARY

[0011] In view of the above, there is a need for improved medicament delivery devices that at least partly solves the problem of the prior art.

[0012] There is hence provided according to a first aspect, a medicament delivery device comprising: at least two disposable cassettes, each disposable cassette containing a medicament and comprising a colored label, the colors of the colored labels of the disposable cassettes being distinct; a drive unit comprising: a receiving interface adapted to receive the disposable cassettes one after the other according to a receiving order; a power module configured to act on the received disposable cassette to expel the medicament; a light emitter configured to emit a colored light in the visible spectrum, and a control unit provided with a predetermined color sequence corresponding to the receiving order of the disposable cassettes in the receiving interface based on the colors of the colored labels, the control unit being configured to control the light emitter to sequentially emit colored lights according to the predetermined color sequence.

[0013] The medicament delivery device can thus provide for improved control of the medicament administration. Thus, the user or caregiver can more easily distinguish each disposable cassette in a regimen (i.e. a medicament administration comprising medicament administration from at least two different disposable cassettes) from another as a means to ensure proper medicament administration order. Moreover, the medicament administration order may be controlled with or without use of a digital transfer of information, e.g. by means of RFID or other communication devices, as the control unit is provided, e.g. pre-programmed, with the predetermined color sequence. At least the predetermined color sequence need not to be sent to the control unit from an external device. Furthermore, the drive unit need not to require information of the number of disposable cassettes for a regimen prior to the medicament administration, as the user or caregiver simply load the disposable cassette corresponding to the matching of the colored label and the light emitted by the light emitter to prompt until there are no remaining disposable cassettes (therefore, the regimen is complete). Thus, the medicament delivery device provides an improved communication of a sequential medicament administration involving medicament administration from at least two different disposable cassettes. The sequential medicament administration may e.g. correspond to a sequenced multi-drug regimen. The medicament administration from a disposable cassette may be referred to as a medicament administration action (executed by the drive unit). The colored label of the disposable cassette thus indicates when in the sequential medicament administration the particular disposable cassette is to be administrated. This may depend on e.g. the characteristics of the medicament in the disposable cassette, such as e.g. the volume of a medicament container holding the medicament and / or the type of medicament in the medicament container.

[0014] Besides that, the control unit is configured to control the light emitter to sequentially emit colored lights according to the predetermined color sequence during a sequential administration involving medicament administration actions from at least two different disposable cassettes. Thus, the control unit controls the light emitter to first emit colored light corresponding to the first color in the predetermined color sequence, the user or caregiver may thus load the disposable cassette into the receiving interface of the drive unit having the colored label matching the emitted colored light. After the medicament administration action of such disposable cassette, the disposable cassette is removed from the receiving interface and the drive unit, and the control unit controls the light emitter to emit colored light corresponding to the second color in the predetermined color sequence, and the user or caregiver may thus load another disposable cassette into the receiving interface of the drive unit having the colored label matching the emitted colored light of the second color in the predetermined color sequence. The light emitter may e.g. comprise a LED.

[0015] In the present disclosure, when the term “distal direction” is used, this refers to the direction pointing away from the dose delivery site during use of the medicament delivery device. When the term “distal part / end” is used, this refers to the part / end of the delivery device, or the parts / ends of the members thereof, which under use of the medicament delivery device is / are located furthest away from the dose delivery site.

[0016] Correspondingly, when the term “proximal direction” is used, this refers to the direction pointing towards the dose delivery site during use of the medicament delivery device.

[0017] When the term “proximal part / end” is used, this refers to the part / end of the delivery device, or the parts / ends of the members thereof, which under use of the medicament delivery device is / are located closest to the dose delivery site.

[0018] Further, the term “longitudinal”, “longitudinally”, “axially” or “axial” refer to a direction extending from the proximal end to the distal end, typically along the device or components thereof in the direction of the longest extension of the device and / or component.

[0019] Similarly, the terms “transverse”, “transversal” and “transversally” refer to a direction generally perpendicular to the longitudinal direction.

[0020] Further, the terms “circumference”, “circumferential”, or “circumferentially” refer to a circumference or a circumferential direction relative to an axis, typically a central axis extending in the direction of the longest extension of the device and / or component.

[0021] Similarly, “radial” or “radially” refer to a direction extending radially relative to the axis, and “rotation”, “rotational” and “rotationally” refer to rotation relative to the axis.

[0022] According to one embodiment, the receiving interface comprises a color sensor configured to detect the color of the colored label of the received disposable cassette. Hereby, the color of the colored label maybe identified by the color sensor. The color sensor may be configured to identify the color of the colored label by comparison with a pre-defined set of colors. The color sensor may e.g. be an optical sensor.

[0023] According to one embodiment, the control unit is configured to compare the detected color of the colored label received from the color sensor with a color of the predetermined color sequence, and in response to a mis-match between the detected color and said color of the predetermined color sequence, indicate an error. Hereby, the user or caregiver will receive an error in case they load a disposable cassette into the receiving interface having a colored label different to the colored light presently emitted by the light emitter. The error may e.g. be indicated by that the control unit controls the light emitter to emit red light and / or a flashing light. In case of using red light as an indicator for the error, the red color is preferably not included in the predetermined color sequence. As an alternative, the error may be indicated by a tactile feedback or a sound.

[0024] According to one embodiment, the color sensor is arranged inside the receiving interface. Hereby, a suitable surrounding of the color sensor is provided. Hence, the color sensor can detect the color of the colored label without external disturbances such as e.g. varying light conditions, which otherwise could be the case if the color sensor would be arranged externally, or at the outside of, the receiving interface. Moreover, the color sensor may be arranged in a position inside the receiving interface which serve the purpose to indicate whether the disposable cassette is inserted correctly or not. For example, in case the color sensor cannot detect a color of the at least partly inserted disposable cassette in the receiving interface, the control unit may detect this and inform the user or caregiver that the disposable cassette is not inserted properly.

[0025] According to one embodiment, the receiving interface forms a receiving recess in the drive unit. The receiving recess may have an inner portion and an outer portion. Thus, the receiving recess may extend from the outer portion, which firstly receive the disposable cassette as it is loaded into the receiving interface, to the inner portion. The inner portion may e.g. be defined by at least 50 %, or at least 70 %, of the receiving recess (by volume, i.e. the innermost 50 %, or innermost 70 %, of the volume of the receiving recess). The color sensor is preferably arranged in the inner portion of the receiving recess.

[0026] According to one embodiment, the control unit is configured to detect an initial condition prior to receiving a first disposable cassettes in the receiving interface, and to control the light emitter to emit a first colored light according to a first color in the predetermined color sequence in response to detecting the initial condition. That is, the initial condition is detected prior to the start of the regimen or the medicament administration comprising medicament administration from at least two different disposable cassettes. For example, the initial condition maybe defined upon start-up of the drive unit (i.e. powering on the drive unit). According to one example, the drive unit is configured to be re-set, e.g. by a re-setting button, and the initial condition is detected upon a re-set of the driver unit.

[0027] According to one embodiment, the control unit is configured to detect an end condition on a medicament delivery action of the first disposable cassette, and to control the light emitter to emit a second colored light according to the second color in the predetermined color sequence in response to detecting the end condition. That is, the end condition is detected subsequent to the start of the regimen or subsequent to the medicament administration action of the first disposable cassette. For example, the end condition maybe defined upon removing, or discharging, the first disposable cassette from the receiving interface of the drive unit. For example, the end condition maybe defined by that the color sensor identify a change from detecting a color (of the colored label of the first disposable cassette) to not detecting a color. It should be understood that the end condition is typically not an end condition of the regimen, but an end condition of the medicament delivery action of the first disposable cassette. Thus, such end condition maybe referred to as a first end condition. In case of the regimen comprising medicament administration from more than two disposable cassettes, a corresponding second end condition, and potentially corresponding further end conditions depending on the number of disposable cassettes included in the regimen, may be detected with corresponding control of the light emitter to emit colored light according to the color of the predetermined color sequence (e.g. the third color in the predetermined color sequence for the second end condition and so on).

[0028] According to one embodiment, the receiving interface is adapted to lock the disposable cassette in an inserted position, wherein the light emitter is configured to indicate when the disposable cassette is locked in the inserted position in the receiving interface. Hereby, the user or caregiver may receive feedback in response of that the disposable cassette is locked in the inserted position. For example, the light emitter may cease to emit colored light in response to that the disposable cassette is locked in the inserted position. For example, the control unit may be configured to detect when the disposable cassette is locked in the inserted position and control the light emitter to cease emitting light in response of such detection. According to one embodiment, the indication that the disposable cassette is locked in the inserted position may be achieved by that the control unit controls the light emitter to emit green light and / or a flashing light. In case of using green light as an indicator, the green color is preferably not included in the predetermined color sequence. Thus, the light emitter may serve as a dual purpose indicator, both for indicating which disposable cassette that is to be loaded to the receiving interface of the drive unit next, and to indicate that the disposable cassette is locked in the inserted position in the receiving interface. Moreover, as previously mentioned, the light emitter may also server the purpose of indicating an error in case the wrong disposable cassette is loaded into the receiving interface of the drive unit, as previously discussed.

[0029] According to one embodiment, the light emitter is arranged inside the receiving interface. Hereby, the light emitter is protected from physical impacts, and also external disturbances such as e.g. varying light conditions, which otherwise could be the case if the light emitter would be arranged externally, or at the outside of, the receiving interface. Moreover, by arranging the light emitter inside the receiving interface, the user or caregiver is guided where the disposable cassette is to be inserted. Referring to the previously mentioned embodiment with the receiving recess, the light emitter may be arranged in the inner portion of the receiving recess. The light emitter and the color sensor may be arranged on opposite walls, or on opposite portions of a wall, inside the inner portion of the receiving recess.

[0030] According to one embodiment, the light emitter is arranged on an outside of the drive unit. According to one embodiment, the medicament delivery device comprises at least two light emitters, one arranged on the outside of the drive unit, and one arranged inside the receiving interface. Both of the two light emitters may be controlled to emit colored light by the control unit as previously described.

[0031] According to one embodiment, the light emitter is arranged to be blocked by the disposable cassette when the disposable cassette is locked in the inserted position in the receiving interface. Hereby, an efficient means to indicate that the disposable cassette is locked in the inserted position in the receiving interface is provided. For example, the light emitter maybe arranged adjacent a locking structure of the receiving interface, wherein the locking structure is arranged to lock to a corresponding receiving structure of the disposable cassette, and wherein when the receiving structure lockingly interacts with the locking structure, the disposable cassette is locked in the inserted position in the receiving interface and the light emitter is blocked by the disposable cassette behind the locking structure. The arrangement of the light emitter inside the receiving interface maybe chosen such that no light, or a very low light, is emitted out of the receiving interface.

[0032] According to one embodiment, the control unit is configured to indicate completion of a medicament administration action of one of the disposable cassettes and / or completion of sequential medicament administration actions of all of the disposable cassettes. Hereby, the user or caregiver knows when the medicament administration action of one of the disposable cassettes is complete and / or when the regimen has ended, and no more disposable cassettes are to be loaded into the receiving interface of the drive unit. As previously described, the indication of completion of a medicament administration action of one of the disposable cassettes (i.e. not completion of the sequential medicament administration actions of all of the disposable cassettes) may be indicated by that the control unit controls the light emitter to emit a colored light according to the subsequent color in the predetermined color sequence (i.e. the next color as compared to color of the predetermined color sequence currently, or recently, emitted by the light emitter). According to one embodiment, the indication of completion of the sequential medicament administration actions of all of the disposable cassettes, may be achieved by that the control unit controls the light emitter to emit a final colored light and / or a flashing light. For instance, in case of using yellow light as an indicator, the yellow color is not included in the predetermined color sequence.

[0033] According to one embodiment, the medicament delivery device further comprises a user interface including a first user-interactive portion and a second user-interactive portion, wherein the control unit is configured to detect an interaction with the first user-interactive portion and to control the light emitter to emit colored light according to the subsequent color in the predetermined color sequence in response of such detection, and wherein the control unit is configured to detect an interaction with the second user- interactive portion and to indicate completion of sequential medicament administration actions of all of the disposable cassettes in response of such detection. Hereby, the user or caregiver may be provided with an additional decision point. For example, the first and second user-interactive portions may be active, or configured to be activated, after the end of a medicament administration action of a disposable cassette, or after the removal of a disposable cassette from the receiving interface of the driver unit. Hereby, the user or caregiver can indicate by interacting with the first user-interactive portion or the second user-interactive portion that this is the end of the regimen, or that there are more disposable cassettes in the regimen. The first user-interactive portion may e.g. be a first button and the second user- interactive portion may e.g. be a second button. Thus, the first user- interactive portion or first button may thus represent “at least one more disposable cassette is left to be administrated” and the second user- interactive portion or second button may thus represent “end of the regimen, there are no more disposable cassette left to be administrated”. For example, the light emitter may be configured to emit the colored light to the first user- interactive portion or first button and to the second user-interactive portion may or second button. Thus, by combining the embodiment with the first and second user-interactive portions with the embodiment of indicating completion of a medicament administration action of one of the disposable cassettes and / or completion of sequential medicament administration actions of all of the disposable cassettes, the first user-interactive portion or first button may emit colored light according to the subsequent color in the predetermined color sequence, and the second user-interactive portion or second button may emit colored light indicating of completion of the sequential medicament administration actions of all of the disposable cassettes (i.e. end of regimen), e.g. yellow light.

[0034] According to one embodiment, the control unit is configured to indicate completion of the sequential medicament administration actions of all of the disposable cassettes by controlling the light emitter to emit colored light of a different color than the colors in the predetermined color sequence. Hereby, the user or caregiver is presented with a colored light which do not correspond to a color included in the colored labels of the disposable cassettes. Thus, the risk of confusing the user or caregiver is reduced.

[0035] According to one embodiment, the medicament delivery device further comprises an electronic reader configured to receive data of a predetermined sequential administration involving medicament administration actions on at least two different disposable cassettes, wherein the control unit is configured to control the light emitter to sequentially emit colored lights according to the predetermined color sequence in response to the data of the predetermined sequential administration. Thus, even though the predetermined color sequence is pre-programmed into the control unit (and hence not communicated to the control unit from an external device) the data of a predetermined sequential administration, typically the number of the disposable cassettes in the regimen, i.e. the regimen length, may be received by the electronic reader and further communicated to the control unit. Thus, the control unit can match the data of the predetermined sequential administration, typically the number of the disposable cassettes in the regimen, to the number of colors in the predetermined color sequence to be sequentially emitted by the light emitter during a sequential administration involving medicament administration actions from at least two different disposable cassettes. The electronic reader may e.g. be based on RFID.

[0036] According to one embodiment, the color of the colored label of each disposable cassette is included in the predetermined color sequence. Hereby the user or caregiver is presented with a colored light which correspond to a color included in the colored labels of the disposable cassettes. Thus, the risk of confusing the user or caregiver is reduced.

[0037] According to one embodiment, the colored label of each disposable cassette comprises a symbol associated with the color of the colored label. For example, a first color may be associated with a triangle, and a second color may be associated with a circle, and so on. Hereby, the disposable cassettes may be further distinguished from each other.

[0038] There is according to a second aspect provided a method for administering at least two disposable cassettes containing medicament. The method comprising: marking each disposable cassette with a colored label, the colors of the colored labels of the disposable cassettes being distinct, according to a predetermined color sequence such that the order for which the disposable cassettes are to be administrated corresponds to the color of the colored labels; providing the at least two disposable cassettes for administration by the drive unit according to the first aspect.

[0039] Effects and features of the second aspect are largely analogous to those described above in connection with the first aspect. Embodiments mentioned in relation to the first aspect are largely compatible with the second aspect.

[0040] According to one embodiment, the method further comprises: sequentially administrating medicament from the least two different disposable cassettes using the drive unit, and controlling, by the control unit according to the first aspect, the light emitter of the drive unit to sequentially emit colored lights according to the predetermined color sequence during the sequential administration.

[0041] With medicament administration, or regimen, is meant that a predefined type, or predefined types, of drug / medicament is to be administered, typically at a predefined rate and for a predefined amount of time. The target patient group may also be predefined for the medicament administration or regimen.

[0042] By means of the disposable cassettes, variable medicament containers having different volumes or different type of medicament are possible to use by the same drive unit. The volume of the medicament container of a disposable cassette can range from smaller volumes of about 2 ml to larger volumes of about io ml or more depending on the size of the disposable cassette. Regardless of medicament volume, the engagement of the disposable cassette with the drive unit forming the medicament delivery device is the same.

[0043] Generally, all terms used in the claims are to be interpreted according to their ordinary meaning in the technical field, unless explicitly defined otherwise herein. All references to "a / an / the element, apparatus, component, means, etc.” are to be interpreted openly as referring to at least one instance of the element, apparatus, component, means, etc., unless explicitly stated otherwise.

[0044] BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Fig. 1 is a perspective view of a medicament delivery device according to embodiments of the present disclosure;

[0046] Fig. 2 is a perspective view of the medicament delivery device with housing removed according to embodiments of the present disclosure;

[0047] Fig. 3 is a perspective view of a medicament delivery device according to embodiments of the present disclosure;

[0048] Fig. 4 is a perspective detailed view of a receiving interface according to embodiments of the present disclosure;

[0049] Fig. 5 is a schematic view of a user interface according to embodiments of the present disclosure;

[0050] Fig. 6 is a schematic view of a colored label according to embodiments of the present disclosure; and

[0051] Fig. 7 is a flowchart illustrating the steps of a method in according to embodiments of the present disclosure.

[0052] DETAILED DESCRIPTION

[0053] The inventive concept will now be described more fully hereinafter with reference to the accompanying drawings, in which exemplifying embodiments are shown. The inventive concept may, however, be embodied in many different forms and should not be construed as limited to the example embodiments set forth herein; rather, these example embodiments are provided by way of example so that this disclosure will be thorough and complete, and will fully convey the scope of the inventive concept to those skilled in the art. Like numbers refer to like elements throughout the description.

[0054] Fig. i shows an example of a medicament delivery device i such as an autoinjector of an injection device according to embodiments of the present disclosure. The medicament delivery device i is configured to expel medicament from a medicament container 13 via a medicament delivery member 2, here embodied as needle, to a user at a dose delivery site. The medicament delivery device 1 extends from a proximal end la to a distal end ib relative to the axis 112.

[0055] The axis 112 is in Fig. 1 a centre axis, from which a circumferential direction 131 relative to the centre axis 112 and a radial direction 132 extending radially relative to the centre axis 112, can be defined.

[0056] The medicament delivery device 1 comprises a drive unit 3 which is connectable to a disposable cassette 4 having a proximal end 4a and a distal end 4b. The drive unit 3 has a corresponding proximal end 3a and distal end 3b, and comprises a housing 6. In Fig. 1, only one disposable cassette 4 is shown, however it should be understood that the different disposable cassettes maybe loaded into the drive unit 3 and used for expelling medicament from the medicament container via the delivery member (i.e. during a medicament administration action), subsequently after each other, as described with reference to Fig. 3.

[0057] The disposable cassette 4 comprises a tubular main body 11 accommodating the medicament container 13 and the thereto arranged medicament delivery member 2 having a proximal end 2a. In the embodiment of Fig. 1, in which the medicament delivery member 2 is a needle, the proximal end 2a is the tip of the needle. The disposable cassette 4 may be adapted to accommodate medicament containers of different volumes, for example ranging from about 1 ml to about 10 ml. The drive unit 3 comprises a receiving interface 10 configured to receive and lock the disposable cassette 4 to the proximal end 3a of the drive unit 3.

[0058] The disposable cassette 4 comprises a colored label 5 indicating where in a sequential medicament administration involving medicament administration from at least two different disposable cassettes, the particular disposable cassette 4 is to be administrated. That is, the colored label 5 represents the ordinal position of the medicament container 13 of the disposable cassette 4 in the regimen, and corresponding to a receiving order for which the drive unit 3 is to receive the disposable cassette 4. This may depend on e.g. the characteristics of the medicament in the medicament container 13, such as e.g. the volume of the medicament container 13 and / or the type of medicament in the medicament container 13.

[0059] Moreover, the disposable cassette 4 may comprises a cap 90 arranged to protect the medicament delivery member 2. In Fig. 1, the cap 90 is shown proximally of the disposable cassette 4, as after the cap 90 has been removed from the medicament delivery member 2 during a cap removal action.

[0060] The disposable cassette 4 may comprise a delivery member cover 7 configured to cover the delivery member 2. The delivery member cover 7 is configured to move axially relative to the tubular main body 11. For example, the delivery member cover 7 maybe moved from a protracted position into a retracted position, shown in Fig. 1, in which the delivery member cover 7 is received further into the tubular main body 11 in order to expose the delivery member 2 of the medicament container 13.

[0061] The medicament delivery device 1 further comprises a light emitter 20 configured to emit a colored light in the visible spectrum, as will be described in the following.

[0062] Fig. 2 is a partly exploded view of the medicament delivery device 1 with the housing 6 removed from the drive unit 3 and the cap 5 removed from the disposable cassette 4. As shown in Fig. 2, the housing 6 maybe divided in two parts, a first housing part 6a and a second housing part 6b, wherein the second housing part 6b is arranged distally of the first housing part 6a.

[0063] The drive unit 3 comprises a power module 8 including a motor 82, a power pack 86 with electronic circuitry and batteries, and a plunger rod 83 configured to move proximally to act on the medicament container 13 to expel medicament via the proximal end 2a of the medicament delivery member 2. The motor 82 is energized by the power pack 86, and is configured to move the plunger rod 83 in the proximal direction during a medicament administration action. The drive unit 3 further comprises a control unit 85 configured to control at least part of the operation of the medicament delivery device, e.g. the control of the motor 82.

[0064] The drive unit 3 of Fig. 2 may furthermore comprises an electric reader 80 for receiving data of an external device of the drive unit 3. In the embodiment of Fig. 2, the electric reader 80, the motor 82, at least a part of the plunger rod 83, the control unit 85 and the power pack 86 are comprised in the drive unit 3, and housed wi thing the housing 6.

[0065] Turning to Fig. 3, showing a medicament delivery device 1’ similar to that of Fig 1, with the same drive unit 3 as described in Fig. 2 including the light emitter 20, but comprising four disposable cassettes 4a, 4b, 4c, 4d. Each one of the disposable cassettes 4a, 4b, 4c, 4d contains a medicament in a corresponding medicament container 13a, 13b, 13c, 13d, and comprises a colored label 5a, 5b, 5c, 5d. As previously described, the color of the colored labels 5a, 5b, 5c, 5d indicates where in a sequential medicament administration involving medicament administration from the four disposable cassettes 4a, 4b, 4c, 4d, a particular disposable cassette 4a, 4b, 4c, 4d is to be administrated. The colors of the colored labels 5a, 5b, 5c, 5d of the disposable cassettes 4a, 4b, 4c, 4d are distinct, i.e. they are distinguishable from each other (e.g. distinguishable by means of a color sensor). The colors of the colored labels 5a, 5b, 5c, 5d may e.g. be chosen as colors being distinctly identified from each other for both color-normal and colordeficient individuals. For example, Table 1 defines one such set of colors that can be reliably identified and distinguished between for both color-normal and color-deficient individuals.

[0066] Table i (based on Woodson’s Human Factors Design Handbook, 1981)

[0067] Color Spec. No.* Color Spec. No.*

[0068] Red 1110 Gray 1625

[0069] Orange 1210 Buff 1745

[0070] Yellow 1310 White 1755

[0071] Blue 10B 7 / 6 Black 1770

[0072] Purple 2715

[0073] *From Fed. Spec. II-C-595 except blue, which is from Munsell (1942). Note that as of February 14, 2017, FED-STD-595 was cancelled and replaced by SAE International's AMS-STD-595.

[0074] Thus, the colors of the colored labels 5a, 5b, 5c, 5d of the disposable cassettes 4a, 4b, 4c, 4d may be chosen as different colors from the list in Table 1.

[0075] Additionally or alternatively, the colors may be defined by the RGB color scale. Thus, the red, green and blue use 8 bits each, and each color is defined by red, green and blue having integer values from o to 255.

[0076] According to one embodiment, colors with culturally defined associations or meanings may be excluded from the selection of the colors of the colored labels 5a, 5b, 5c, 5d , e.g., red (for “stop” or “error”) and green (for “go” or “correct”).

[0077] The receiving interface 10 of the drive unit 3 is thus adapted to receive the disposable cassettes 4a, 4b, 4c, 4d one after the other according to a receiving order. The receiving order is thus corresponding to the ordinal position of each medicament container 13a, 13b, 13c, 13d in the regimen. Moreover, the control unit 85 of the drive unit is provided with, e.g. by being programmed with, or pre-programmed with, a predetermined color sequence corresponding to the receiving order of the disposable cassettes 4a, 4b, 4c, 4d. This is for example shown in Fig. 1, as the control unit 85 may access a memory in which data 90 of the predetermined color sequence is stored. The predetermined color sequence and thus the receiving order are based on colors of the colored labels 5a, 5b, 5c, 5d. Hereby, the control unit 85 is configured to control the light emitter 20 to sequentially emit colored lights according to the predetermined color sequence during the sequential medicament administration.

[0078] For example, the predetermined color sequence may comprise the following colors in the listed order: orange, blue, purple, white. Thus, the first disposable cassette 4a to be loaded into the receiving interface 10 and deliver medicament according to a first medicament administration action has an orange color of the colored label 5a, the second disposable cassette 4b to be loaded into the receiving interface 10 and deliver medicament according to a second medicament administration action has a blue color of the colored label 5b, the third disposable cassette 4c to be loaded into the receiving interface 10 and deliver medicament according to a third medicament administration action has a purple color of the colored label 5c, and the fourth, and last, disposable cassette 4d to be loaded into the receiving interface 10 and deliver medicament according to a fourth medicament administration action has a white color of the colored label 5d. The colors of the colored labels 5a, 5b, 5c, 5d if the disposable cassettes 4a, 4b, 4c, 4d are thus included in the predetermined color sequence. The four disposable cassettes 4a, 4b, 4c, 4d are to be received in the receiving recess 10 according to the following receiving order: the first disposable cassette 4a, the second disposable cassette 4b, the third disposable cassette 4c, and lastly the fourth disposable cassette 4d. Each one of the disposable cassettes 4a, 4b, 4c ,4d is removed from the receiving interface 10 subsequent to performing its corresponding medicament delivery action.

[0079] Thus, the control unit 85 is configured to control the light emitter 20 to sequentially emit colored lights according to the predetermined color sequence, i.e. in this example first orange, then blue, then purple and lastly white, as the disposable cassettes 4a, 4b, 4c, 4d are loaded, one at a time and after each other, to perform the first to fourth medicament administration actions. Hence, the control unit 85 is configured to control the light emitter 20 to sequentially emit colored lights according to the predetermined color sequence during the sequential administration involving the first to fourth medicament administration actions from the four different disposable cassettes 4a, 4b, 4c, 4d.

[0080] The control unit 85 may be configured to detect an initial condition prior to receiving the first disposable cassette 4a in the receiving interface 10. Moreover, the control unit maybe configured to control the light emitter 20 to emit colored light according to the first color in the predetermined color sequence, here being orange, in response to detecting the initial condition. Thus, the user or caregiver understands from the emitted colored light from the light emitter 20, here being orange, that the disposable cassette having a colored label for which the color matches that of the emitted light, here being the first disposable cassette 4a, is to be chosen to be loaded to the receiving interface 10 of the drive unit 3. Thus, the first disposable cassette 4a is first in the receiving order of the disposable cassettes 4a, 4b, 4c, 4d.

[0081] The control unit 85 may be configured to detect a first end condition of the medicament delivery action of the first disposable cassette 4a. Moreover, the control unit 85 maybe configured to control the light emitter 20 to emit colored light according to the second color in the predetermined color sequence, here being blue, in response to detecting the first end condition. The control unit 85 may be configured to detect the first end condition in response to that the medicament delivery action of the first disposable cassette 4a ends, or in response to that the first disposable cassette 4a is removed from the receiving interface 10. Thus, the user or caregiver understands from the emitted colored light from the light emitter 20, here being blue, that the disposable cassette having a colored label for which the color matches that of the emitted light, here being the second disposable cassette 4b, is to be chosen to be loaded to the receiving interface 10 of the drive unit 3. Thus, the second disposable cassette 4b is second in the receiving order of the disposable cassettes 4a, 4b, 4c, 4d.

[0082] The control unit 85 may be configured to detect a second end condition of the medicament delivery action of the second disposable cassette 4b. Moreover, the control unit 85 maybe configured to control the light emitter 20 to emit colored light according to the third color in the predetermined color sequence, here being purple, in response to detecting the second end condition. The control unit 85 may be configured to detect the second end condition in response to that the medicament delivery action of the second disposable cassette 4b ends, or in response to that the second disposable cassette 4b is removed from the receiving interface 10. Thus, the user or caregiver understands from the emitted colored light from the light emitter 20, here being purple, that the disposable cassette having a colored label for which the color matches that of the emitted light, here being the third disposable cassette 4c, is to be chosen to be loaded to the receiving interface 10 of the drive unit 3. Thus, the third disposable cassette 4c is third in the receiving order of the disposable cassettes 4a, 4b, 4c, 4d.

[0083] The control unit 85 may be configured to detect a third end condition of the medicament delivery action of the third disposable cassette 4b. Moreover, the control unit 85 maybe configured to control the light emitter 20 to emit colored light according to the fourth color in the predetermined color sequence, here being white, in response to detecting the third end condition. The control unit 85 may be configured to detect the third end condition in response to that the medicament delivery action of the third disposable cassette 4c ends, or in response to that the third disposable cassette 4c is removed from the receiving interface 10. Thus, the user or caregiver understands from the emitted colored light from the light emitter 20, here being white, that the disposable cassette having a colored label for which the color matches that of the emitted light, here being the fourth disposable cassette 4d, is to be chosen to be loaded to the receiving interface 10 of the drive unit 3. Thus, the fourth disposable cassette 4d is fourth in the receiving order of the disposable cassettes 4a, 4b, 4c, 4d. Thus, the control unit 85 maybe configured to indicate completion of each medicament administration action of the disposable cassettes 4a, 4b, 4c, 4d, by controlling the light emitter to emit colored light with a color being subsequent, or next, in the predetermined color sequence. The control unit 85 maybe configured to indicate the status, or progress, of the current ongoing medicament delivery action, for example by controlling the light emitter 20 to show a segmented status bar. For example, the segmented status bar maybe comprised of five bar segments, wherein one bar segment represents the beginning of the ongoing medicament delivery action and five bar segments represents the end of the ongoing medicament delivery action.

[0084] The control unit 85 maybe configured to indicate completion of the sequential medicament administration, i.e. of all the first to fourth medicament administration actions, of all of the disposable cassettes 4a, 4b, 4c, 4d, by controlling the light emitter 20 to emit colored light with a color being different to all of the colors in the predetermined color sequence, e.g. yellow light. Moreover, the control unit 85 may control the light emitter 20 to emit the light as a flashing light, e.g. a flashing yellow light.

[0085] Fig. 4 shows an example of a receiving interface no which may replace the receiving interface 10 of the medicament delivery device 1 of Figs. 1-2. The receiving interface comprises a color sensor 130 configured to detect the color of the colored label of a disposable cassette 4a, 4b, 4c, 4d. As shown in Fig. 4, the color sensor 130 is arranged inside the receiving interface no. Thus, as disposable cassette 4a, 4b, 4c, 4d is inserted into the receiving interface 110, the color sensor 130 may detect the color of the colored label. Preferably, the receiving interface comprises a guide track 112 configured to guide the disposable cassette received in the receiving interface 110 to a position in which the color sensor 130 is able to read the colored label and thereby detect the color of the colored label.

[0086] The receiving interface no further comprises a light emitter 120 arranged inside the receiving interface no. The light emitter 120 may correspond to the light emitter 20 of the medicament delivery device 1 of Fig. 1. However, it is within the present disclosure to provide a medicament delivery device comprising both the light emitter 20 and the light emitter 120.

[0087] The control unit 85 may be configured to compare the detected color of the colored label received from the color sensor 130 with the predetermined color sequence, and in response to a mis-match between the detected color and the predetermined color sequence for the current disposable cassette 4a, 4b, 4c, 4d received in the receiving interface no, indicate an error. The error may e.g. be indicated by that the control unit 85 controls the light emitter 120 to emit red light and / or a flashing light. As an alternative, the error may be indicated by a tactile feedback or a sound.

[0088] The receiving interface no maybe adapted to lock the disposable cassette 4a, 4b, 4c, 4d currently received in the receiving interface no in an inserted position. For example, the previously mentioned guide track 112 may serve the purpose of guiding the disposable cassette 4a, 4b, 4c, 4d to the inserted position, and a locking structure of the receiving interface no may be arranged to lock to a corresponding receiving structure of the disposable cassette 4a, 4b, 4c, 4d. Hereby, the disposable cassette 4a, 4b, 4c, 4d may be guided to, and locked into, the inserted position in the receiving interface 110.

[0089] The light emitter 120 maybe configured to indicate when the disposable cassette 4a, 4b, 4c, 4d is locked in the inserted position in the receiving interface 110. For example the light emitter 120 maybe arranged to be blocked by the disposable cassette 4a, 4b, 4c, 4d when the disposable cassette 4a, 4b, 4c, 4d is locked in the inserted position in the receiving interface no. For example, the light emitter 120 maybe arranged adjacent the locking structure, or the guide track 112 of the receiving interface no. Hereby, when the disposable cassette 4a, 4b, 4c, 4d is locked in the inserted position in the receiving interface no, the light emitter 120 is blocked by the disposable cassette 4a, 4b, 4c, 4d behind the locking structure or the guide track 112. The arrangement of the light emitter 120 inside the receiving interface 110 maybe chosen such that no light, or a very low light, is emitted out of the receiving interface no when a disposable cassette 4a, 4b, 4c, 4d is locked in the inserted position in the receiving interface no.

[0090] Fig. 5 shows an example of a user interface 200 which maybe comprised in an outer surface of the drive unit 3 described with reference to Figs. 1-2. The user interface 200 is typically configured to communicate with the control unit 85. The user interface 200 comprises at least a first user-interactive portion 210 and a second user-interactive portion 220. The first user- interactive portion 210 maybe associated with a scenario in which at least one more disposable cassette is left to be administrated. Thus, the control unit 85 may configured to detect an interaction with the first user-interactive portion 210 and to control the light emitter 20, 120 to emit colored light according to the subsequent color in the predetermined color sequence in response of such detection. The second user-interactive portion 220 maybe associated with an end of the regimen, i.e. that there are no more disposable cassette left to be administrated. Thus, the control unit 85 maybe configured to detect an interaction with the second user-interactive portion 220 and to indicate completion of sequential medicament administration actions of all of the disposable cassettes in response of such detection. Optionally, the user interface 200 comprises a third user-interactive portion 230 associated with initiating a medicament administration action of the disposable cassette received in the receiving interface 10, no. Thus, the control unit 85 maybe configured to detect an interaction with the third user-interactive portion 230 and to control the motor 82 to move the plunger rod 83 in the proximal direction to perform the medicament administration action, as described with reference to Fig. 2.

[0091] Turning back to Fig. 2, the electronic reader 80 maybe configured to receive data 92 of a predetermined sequential administration involving medicament administration actions from at least two different disposable cassettes 4a, 4b, 4c, 4d. Moreover, the control unit 85 may be configured to control the light emitter 20, 120 to sequentially emit colored lights according to the predetermined color sequence in response to the data 92 of the predetermined sequential administration. Thus, even though the predetermined color sequence is pre-programmed into the control unit 85, the data 92 of a predetermined sequential administration, which typically comprises the number of disposable cassettes included in the regimen, may be received by the electronic reader 80 and further communicated to the control unit 85. Thus, the control unit 85 can match the data 92 of the predetermined sequential administration, at least the number of the disposable cassettes 4a, 4b, 4c, 4d in the regimen, to the amount of colors in the predetermined color sequence to be sequentially emitted by the light emitter 20, 120 during a sequential administration. For example, in case the number of disposable cassettes 4a, 4b, 4c, 4d in the regimen is two, the control unit 85 determines that the first color to be emitted is orange, and the second color to be emitted is blue (for the predetermined color sequence described earlier) and if the number of disposable cassettes 4a, 4b, 4c, 4d in the regimen is three, the control unit 85 determines that the first color to be emitted is orange, the second color to be emitted is blue, and the third color to be emitted is purple.

[0092] Fig. 6 shows an example embodiment the colored label 5 of the disposable cassette 4 of Fig. 1. However, any one of the disposable cassettes 4a, 4b, 4c, 4d may have a corresponding colored label, with at least the color varies between the colored labels 5a, 5b, 5c, 5d. The colored label 5 comprises a first field 5’ which bears the color of the colored label (here represented by a square pattern). Thus, the previously mentioned color sensor 130 is configured to read the first field 5’ and detect the color in the first field 5’. Moreover, the colored label comprises a second field 5” comprising a symbol associated with the color in the first filed 5’. Here, the symbol is a cross. Each color in the predetermined color sequence may be associated with a specific symbol, e.g. a diamond or a circle. The color sensor 130 maybe configured to also detect the symbol in the second field 5”.

[0093] Turning to Fig. 7 showing a flow chart of the steps of a method for administering at least two disposable cassettes containing medicament, such as at least two of the disposable cassettes 4a, 4b, 4c, 4d described with reference to Fig. 3. In a first step Sio, each disposable cassette 4a, 4b, 4c, 4d is marked with a colored label 5a, 5b, 5c, 5d, the colors of the colored labels 5a, 5b, 5c, 5d of the disposable cassettes 4a, 4b, 4c, 4d being distinct. The disposable cassettes 4a, 4b, 4c, 4d are colored marked according to a predetermined color sequence such that the order for which the disposable cassettes 4a, 4b, 4c, 4d are to be administrated, according to a pre-defined receiving order, corresponds to the color of the colored labels 5a, 5b, 5c, 5d.

[0094] In a second step S20, the at least two disposable cassettes 4a, 4b, 4c, 4d are provided for administration by the drive unit 2 as described with reference to Fig. 3-

[0095] In a third step S30, medicament from the least two different disposable cassettes 4a, 4b, 4c, 4d are sequentially administrated using the drive unit 2, while the control unit 85 controls the light emitter 20, 120 to sequentially emit colored lights according to the predetermined color sequence during the sequential administration.

[0096] The control unit 85 described herein may comprise processing circuitry, logic circuit and / or further control units, including a microprocessor, microcontroller, programmable digital signal processor or another programmable device. The processing circuitry may also, or instead, each include an application specific integrated circuit, a programmable gate array or programmable array logic, a programmable logic device, or a digital signal processor. Where the processing circuitry includes a programmable device such as the microprocessor, microcontroller or programmable digital signal processor mentioned above, the processor may further include computer executable code that controls operation of the programmable device.

[0097] Possible wireless communication methods for the electronic reader 80 include RFID, Bluetooth and Cellular Networks. Bluetooth connectivity requires a smart device to transmit the stored data to the network and it requires a pairing action between the pad and the smart device before being able to use the supporting pad in case of 2-way connection. But it is a cheaper alternative and it requires less space on PCB. A i-way connection does not require pairing. The cellular network does not require any pairing process, it can be used as a plug-n-play device, no prior setup is needed, but it is more expensive and it requires more space on PCB.

[0098] The medicament delivery devices described herein can be used for the treatment and / or prophylaxis of one or more of many different types of disorders.

[0099] Exemplary disorders include, but are not limited to: rheumatoid arthritis, inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis), hypercholesterolaemia and / or dyslipidemia, cardiovascular disease, diabetes (e.g. type 1 or 2 diabetes), psoriasis, psoriatic arthritis, spondyloarthritis, hi dradenitis suppurativa, Sjogren's syndrome, migraine, cluster headache, multiple sclerosis, neuromyelitis optica spectrum disorder, anaemia, thalassemia, paroxysmal nocturnal hemoglobinuria, hemolytic anaemia, hereditary angioedema, systemic lupus erythematosus, lupus nephritis, myasthenia gravis, Behqet's disease, hemophagocytic lymphohistiocytosis, atopic dermatitis, retinal diseases (e.g., age-related macular degeneration, diabetic macular edema), uveitis, infectious diseases, bone diseases (e.g., osteoporosis, osteopenia), asthma, chronic obstructive pulmonary disease, thyroid eye disease, nasal polyps, transplant, acute hypoglycaemia, obesity, anaphylaxis, allergies, sickle cell disease, Alzheimer’s disease, Parkinson’s disease, dementia with Lewy bodies, systemic infusion reactions, immunoglobulin E (IgE)-mediated hypersensitivity reactions, cytokine release syndrome, immune deficiencies (e.g., primary immunodeficiency, chronic inflammatory demyelinating polyneuropathy), enzyme deficiencies (e.g., Pompe disease, Fabry disease, Gaucher disease), growth factor deficiencies, hormone deficiencies, coagulation disorders (e.g., hemophilia, von Willebrand disease, Factor V Leiden), and cancer.

[0100] Exemplary drugs that could be included in the medicament delivery devices described herein include, but are not limited to, immuno-oncology or biooncology medications such as immune checkpoints, cytokines, chemokines, clusters of differentiation, interleukins, integrins, growth factors, coagulation factors, enzymes, enzyme inhibitors, retinoids, steroids, signaling proteins, pro-apoptotic proteins, anti-apoptotic proteins, T-cell receptors, B-cell receptors, or costimulatory proteins.

[0101] Exemplary drugs that could be included in medicament delivery devices described herein include, but are not limited to, those exhibiting a proposed mechanism of action, such as human epidermal growth factor receptor 2 (HER-2) receptor modulators, interleukin (IL) modulators, interferon (IFN) modulators, complement modulators, glucagon-like peptide-i (GLP-i) modulators, glucose-dependent insulinotropic polypeptide (GIP) modulators, cluster of differentiation 38 (CD38) modulators, cluster of differentiation 22 (CD22) modulators, Ci esterase modulators, bradykinin modulators, C-C chemokine receptor type 4 (CCR4) modulators, vascular endothelial growth factor (VEGF) modulators, B-cell activating factor (BAFF), P-selectin modulators, neonatal Fc receptor (FcRn) modulators, calcitonin gene-related peptide (CGRP) modulators, epidermal growth factor receptor (EGFR) modulators, cluster of differentiation 79B (CD79B) modulators, tumor- associated calcium signal transducer 2 (Trop-2) modulators, cluster of differentiation 52 (CD52) modulators, B-cell maturation antigen (BCMA) modulators, enzyme modulators, platelet-derived growth factor receptor A (PDGFRA) modulators, cluster of differentiation 319 (CD319 or SLAMF7) modulators, programmed cell death protein 1 and programmed death-ligand 1 (PD-1 / PD-L1) inhibitors / modulators, B-lymphocyte antigen cluster of differentiation 19 (CD 19) inhibitors, B-lymphocyte antigen cluster of differentiation 20 (CD20) modulators, cluster of differentiation 3 (CD3) modulators, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors, T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) modulators, T cell immunoreceptor with Ig and ITIM domains (TIGIT) modulators, V-domain Ig suppressor of T cell activation (VISTA) modulators, indoleamine 2,3-dioxygenase (IDO or INDO) modulators, poliovirus receptor-related immunoglobulin domain-containing protein (PVRIG) modulators, lymphocyte-activation gene 3 (LAG3; also known as cluster of differentiation 223 or CD223) antagonists, cluster of differentiation 276 (CD276 or B7-H3) antigen modulators, cluster of differentiation 47 (CD47) antagonists, cluster of differentiation 30 (CD30) modulators, cluster of differentiation 73 (CD73) modulators, cluster of differentiation 66 (CD66) modulators, cluster of differentiation W137 (CDW137) agonists, cluster of differentiation 158 (CD158) modulators, cluster of differentiation 27 (CD27) modulators, cluster of differentiation 58 (CD58) modulators, cluster of differentiation 80 (CD80) modulators, cluster of differentiation 33 (CD33) modulators, cluster of differentiation 159 (CD159 or NKG2) modulators, glucocorticoid-induced TNFR-related (GITR) protein modulators, Killer Ig- like receptor (KIR) modulators, growth arrest-specific protein 6 (GAS6) / AXL pathway modulators, A proliferation-inducing ligand (APRIL) receptor modulators, human leukocyte antigen (HLA) modulators, epidermal growth factor receptor (EGFR) modulators, B-lymphocyte cell adhesion molecule modulators, cluster of differentiation W123 (CDW123) modulators, Erbb2 tyrosine kinase receptor modulators, endoglin modulators, mucin modulators, mesothelin modulators, hepatitis A virus cellular receptor 2 (HAVCR2) antagonists, cancer-testis antigen (CTA) modulators, tumor necrosis factor receptor superfamily, member 4 (TNFRSF4 or 0X40) modulators, adenosine receptor modulators, inducible T cell co-stimulator (ICOS) modulators, cluster of differentiation 40 (CD40) modulators, tumorinfiltrating lymphocytes (TIL) therapies, or T-cell receptor (TCR) therapies.

[0102] Exemplary drugs that could be included in the medicament delivery devices described herein include, but are not limited to: etanercept, abatacept, adalimumab, evolocumab, exenatide, secukinumab, erenumab, galcanezumab, fremanezumab-vfrm, alirocumab, methotrexate (amethopterin), tocilizumab, interferon beta-ia, interferon beta-ib, peginterferon beta-ia, sumatriptan, darbepoetin alfa, belimumab, sarilumab, semaglutide, dupilumab, reslizumab, omalizumab, glucagon, epinephrine, naloxone, insulin, amylin, vedolizumab, eculizumab, ravulizumab, crizanlizumab-tmca, certolizumab pegol, satralizumab, denosumab, romosozumab, benralizumab, emicizumab, tildrakizumab, ocrelizumab, ofatumumab, natalizumab, mepolizumab, risankizumab-rzaa, ixekizumab, and immune globulins.

[0103] Exemplary drugs that could be included in the medicament delivery devices described herein may also include, but are not limited to, oncology treatments such as ipilimumab, nivolumab, pembrolizumab, atezolizumab, durvalumab, avelumab, cemiplimab, rituximab, trastuzumab, ado- trastuzumab emtansine, fam-trastuzumab deruxtecan-nxki, pertuzumab, transtuzumab-pertuzumab, alemtuzumab, belantamab mafodotin-blmf, bevacizumab, blinatumomab, brentuximab vedotin, cetuximab, daratumumab, elotuzumab, gemtuzumab ozogamicin, 90-Yttrium- ibritumomab tiuxetan, isatuximab, mogamulizumab, moxetumomab pasudotox, obinutuzumab, ofatumumab, olaratumab, panitumumab, polatuzumab vedotin, ramucirumab, sacituzumab govitecan, tafasitamab, or margetuximab.

[0104] Exemplary drugs that could be included in the medicament delivery devices described herein include “generic” or biosimilar equivalents of any of the foregoing, and the foregoing molecular names should not be construed as limiting to the “innovator” or “branded” version of each, as in the nonlimiting example of innovator medicament adalimumab and biosimilars such as adalimumab-afzb, adalimumab-atto, adalimumab-adbm, and adalimumab-adaz.

[0105] Exemplary drugs that could be included in the medicament delivery devices described herein also include, but are not limited to, those used for adjuvant or neoadjuvant chemotherapy, such as an alkylating agent, plant alkaloid, antitumor antibiotic, antimetabolite, or topoisomerase inhibitor, enzyme, retinoid, or corticosteroid. Exemplary chemotherapy drugs include, by way of example but not limitation, 5-fluorouracil, cisplatin, carboplatin, oxaliplatin, doxorubicin, daunorubicin, idarubicin, epirubicin, paclitaxel, docetaxel, cyclophosphamide, ifosfamide, azacitidine, decitabine, bendamustine, bleomycin, bortezomib, busulfan, cabazitaxel, carmustine, cladribine, cytarabine, dacarbazine, etoposide, fludarabine, gemcitabine, irinotecan, leucovorin, melphalan, methotrexate, pemetrexed, mitomycin, mitoxantrone, temsirolimus, topotecan, valrubicin, vincristine, vinblastine, or vinorelbine.

[0106] Exemplary drugs that could be included in the medicament delivery devices described herein also include, but are not limited to, analgesics (e.g., acetaminophen), antipyretics, corticosteroids (e.g. hydrocortisone, dexamethasone, or methylprednisolone), antihistamines (e.g., diphenhydramine or famotidine), antiemetics (e.g., ondansetron), antibiotics, antiseptics, anticoagulants, fibrinolytics (e.g., recombinant tissue plasminogen activator [r-TPA]), antithrombolytics, or diluents such as sterile water for injection (SWFI), 0.9% Normal Saline, 0.45% normal saline, 5% dextrose in water, 5% dextrose in 0.45% normal saline, Lactated Ringer’s solution, Heparin Lock Flush solution, 100 U / mL Heparin Lock Flush Solution, or 5000 U / mL Heparin Lock Flush Solution.

[0107] Pharmaceutical formulations including, but not limited to, any drug described herein are also contemplated for use in the medicament delivery devices described herein, for example pharmaceutical formulations comprising a drug as listed herein (or a pharmaceutically acceptable salt of the drug) and a pharmaceutically acceptable carrier. Such formulations may include one or more other active ingredients (e.g., as a combination of one or more active drugs), or maybe the only active ingredient present, and may also include separately administered or co-formulated dispersion enhancers (e.g. an animal-derived, human-derived, or recombinant hyaluronidase enzyme), concentration modifiers or enhancers, stabilizers, buffers, or other excipients.

[0108] Exemplary drugs that could be included in the medicament delivery devices described herein include, but are not limited to, a multi-medication treatment regimen such as AC, Dose-Dense AC, TCH, GT, EC, TAC, TC, TCHP, CMF, FOLFOX, mF0LF0X6, mFOLFOXy, FOLFCIS, CapeOx, FLOT, DCF, FOLFIRI, FOLFIRINOX, FOLFOXIRI, IROX, CHOP, R-CHOP, RCHOP-21, Mini-CHOP, Maxi-CHOP, VR-CAP, Dose-Dense CHOP, EPOCH, Dose-Adjusted EPOCH, R-EPOCH, CODOX-M, IVAC, HyperCVAD, R- HyperCVAD, SC-EPOCH-RR, DHAP, ESHAP, GDP, ICE, MINE, CEPP, CDOP, GemOx, CEOP, CEPP, CHOEP, CHP, GCVP, DHAX, CALGB 8811, HIDAC, MOpAD, 7 + 3, 5 +2, 7 + 4, MEC, CVP, RBAC500, DHA-Cis, DHA- Ca, DHA-Ox, RCVP, RCEPP, RCEOP, CMV, DDMVAC, GemFLP, ITP, VIDE, VDC, VAI, VDC-IE, MAP, PCV, FCR, FR, PCR, HDMP, OFAR, EMA / CO, EMA / EP, EP / EMA, TP / TE, BEP, TIP, VIP, TPEx, ABVD, BEACOPP, AVD, Mini-BEAM, IGEV, C-MOPP, GCD, GEMOX, CAV, DT-PACE, VTD-PACE, DCEP, ATG, VAC, VelP, OFF, GTX, CAV, AD, MAID, AIM, VAC-IE, ADOC, or PE.

[0109] Exemplary types of drugs that could be included in the medicament delivery devices described herein include, but are not limited to, small molecules, hormones, cytokines, blood products, enzymes, vaccines, anticoagulants, immunosuppressants, antibodies, antibody-drug conjugates, neutralizing antibodies, reversal agents, radioligand therapies, radioisotopes and / or nuclear medicines, diagnostic agents, bispecific antibodies, proteins, fusion proteins, peptibodies, polypeptides, pegylated proteins, protein fragments, nucleotides, protein analogues, protein variants, protein precursors, protein derivatives, chimeric antigen receptor T cell therapies, cell or gene therapies, oncolytic viruses, or immunotherapies.

[0110] The inventive concept has mainly been described above with reference to a few examples. However, as is readily appreciated by a person skilled in the art, other embodiments than the ones disclosed above are equally possible within the scope of the inventive concept, as defined by the appended claims.

Claims

CLAIMS1. A medicament delivery device (1, 1’) comprising: at least two disposable cassettes (4, 4a, 4b, 4c, 4d), each disposable cassette (4, 4a, 4b, 4c, 4d) containing a medicament and comprising a colored label (5, 5a, 5b, 5c, 5d), the colors of the colored labels (5, 5a, 5b, 5c, 5d) of the disposable cassettes (4, 4a, 4b, 4c, 4d) being distinct, a drive unit (3) comprising: a receiving interface (10, no) adapted to receive the disposable cassettes (4, 4a, 4b, 4c, 4d) one after the other according to a receiving order, a power module (8) configured to act on the received disposable cassette (4, 4a, 4b, 4c, 4d) to expel the medicament, a light emitter (20, 120) configured to emit a colored light in the visible spectrum, a control unit (85) provided with a predetermined color sequence corresponding to the receiving order of the disposable cassettes (4, 4a, 4b, 4c, 4d) in the receiving interface (10, no) based on the colors of the colored labels (5, 5a, 5b, 5c, 5d), the control unit (85) being configured to control the light emitter (20, 120) to sequentially emit colored lights according to the predetermined color sequence during a sequential administration involving medicament administration actions from at least two different disposable cassettes (4, 4a, 4b, 4c, 4d).

2. A medicament delivery device (1, 1’) according to claim 1, wherein the receiving interface (10, no) comprises a color sensor (130) configured to detect the color of the colored label (5, 5a, 5b, 5c, 5d) of the received disposable cassette (4, 4a, 4b, 4c, 4d).

3. The medicament delivery device (1, 1’) according to claim 2, wherein the control unit (85) is configured to compare the detected color of the colored label (5, 5a, 5b, 5c, 5d) received from the color sensor (130) with a color of the predetermined color sequence, and in response to a mis-match between the detected color and said color of the predetermined color sequence, indicate an error.

4. The medicament delivery device (1, 1’) according to any one of claims 2-3, wherein the color sensor (130) is arranged inside the receiving interface (no).

5. The medicament delivery device (1, 1’) according to any one of the preceding claims, wherein the control unit (85) is configured to detect an initial condition prior to receiving a first disposable cassettes (4, 4a, 4b, 4c, 4d) in the receiving interface (10, no), and to control the light emitter (20, 120) to emit a first colored light according to a first color in the predetermined color sequence in response to detecting the initial condition.

6. The medicament delivery device (1, 1’) according to claim 5, wherein the control unit (85) is configured to detect an end condition of a medicament delivery action on the first disposable cassette (4, 4a, 4b, 4c, 4d), and to control the light emitter (20, 120) to emit a second colored light according to the second color in the predetermined color sequence in response to detecting the end condition.

7. The medicament delivery device (1, 1’) according to any one of the preceding claims, wherein the receiving interface (10, no) is adapted to lock the disposable cassette (4, 4a, 4b, 4c, 4d) in an inserted position, and wherein the light emitter (20, 120) is configured to indicate when the disposable cassette (4, 4a, 4b, 4c, 4d) is locked in the inserted position in the receiving interface (10, no).

8. The medicament delivery device (1, 1’) according to any one of the preceding claims, wherein the control unit (85) is configured to indicate completion of a medicament administration action of one of the disposablecassettes (4, 4a, 4b, 4c, 4d) and / or completion of sequential medicament administration actions of all of the disposable cassettes (4, 4a, 4b, 4c, 4d).

9. The medicament delivery device (1, 1’) according to any one of the preceding claims, further comprising a user interface (200) including a first user-interactive portion (210) and a second user-interactive portion (220), wherein the control unit (85) is configured to detect an interaction with the first user-interactive portion (210) and to control the light emitter (20, 120) to emit colored light according to the subsequent color in the predetermined color sequence in response of such detection, and wherein the control unit (85) is configured to detect an interaction with the second user-interactive portion (220) and to indicate completion of sequential medicament administration actions of all of the disposable cassettes (4, 4a, 4b, 4c, 4d) in response of such detection.

10. The medicament delivery device (1, 1’) according to claim 9, wherein the control unit (85) is configured to indicate completion of the sequential medicament administration actions of all of the disposable cassettes (4, 4a, 4b, 4c, 4d) by controlling the light emitter (20, 120) to emit a final colored light of a different color than the colors in the predetermined color sequence.

11. The medicament delivery device (1. 1’) according to any one of the preceding claims, further comprising an electronic reader (80) configured to receive data (92) of a predetermined sequential administration involving medicament administration actions on at least two different disposable cassettes (4, 4a, 4b, 4c, 4d), wherein the control unit (85) is configured to control the light emitter (20, 120) to sequentially emit colored lights according to the predetermined color sequence in response to the data (92) of the predetermined sequential administration.

12. The medicament delivery device (1, 1’) according to any one of the preceding claims, wherein the color of the colored label (5, 5a, 5b, 5c, 5d) of each disposable cassette (4, 4a, 4b, 4c, 4d) is included in the predetermined color sequence.13- The medicament delivery device (1, 1’) according to any one of the preceding claims, wherein the colored label (5, 5a, 5b, 5c, 5d) of each disposable cassette (4, 4a, 4b, 4c, 4d) comprises a symbol associated with the color of the colored label (5, 5a, 5b, 5c, 5d).

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