Liquid aliquoting device

Abstract

A liquid aliquoting device, comprising: a housing (100), a heat preservation compartment (110) and an aliquoting compartment (120) which are spaced apart from each other being provided in the housing (100), wherein the heat preservation compartment (110) is used for accommodating an aliquoting-pending container (111) and for performing heat preservation on the aliquoting-pending container (111), and the aliquoting compartment (120) is used for accommodating a plurality of aliquot bags (310) and for performing heat preservation on the aliquot bags (310); a temperature control mechanism (200) comprising a first temperature control assembly (210) mounted in the heat preservation compartment (110) and used for adjusting the temperature in the heat preservation compartment (110); an aliquoting mechanism (300) mounted in the aliquoting compartment (120) and used for aliquoting liquid in the aliquoting-pending container (111) to the aliquot bags (310); and a liquid path mechanism (400) mounted on the housing (100) and used for aliquoting the liquid in the aliquoting-pending container (111) to the aliquot bags (310) by means of the aliquoting mechanism (300).

Description

Liquid filling equipment

[0001] This application claims priority to the Chinese patent application filed with the China Patent Office on October 31, 2023, with application number 202311439941.0 and invention name “Liquid Packaging Equipment”, the entire contents of which are incorporated by reference into this application. Technical Field

[0002] The present application belongs to the field of biomedical technology, and in particular relates to a liquid packaging device. Background Art

[0003] Cell preparation packaging technology is an important part of the field of biomedical technology and is crucial to cell therapy and pharmaceutical preparation. If the requirements for stable and high-precision packaging cannot be met, it will affect the therapeutic effect of the cell preparation and delay the patient's treatment. In the prior art, the measurement of liquid volume during packaging is usually achieved through equipment and methods such as manual start and stop of peristaltic pumps, weighing, and manual recording. The inventors realized that the above method has a slow packaging speed and cannot quickly package a large dose of cell preparation products into packaging bags in a short time. In addition, due to the slow packaging speed during the packaging process, the above method may cause damage to the integrity and activity of the cell preparation due to temperature changes, thereby reducing the packaging quality.

[0004] Application Contents

[0005] The present application provides a liquid packaging device to address the problems of slow packaging speed and low packaging quality in the prior art liquid packaging devices.

[0006] In view of the above technical problems, the present invention provides a liquid packaging device, comprising:

[0007] A casing, wherein the casing is provided with a heat preservation chamber for accommodating containers to be packaged and for keeping the containers to be packaged warm, and a packaging chamber for accommodating a plurality of packaging bags;

[0008] a temperature control mechanism, comprising a first temperature control component installed in the heat preservation chamber and used to adjust the temperature in the heat preservation chamber;

[0009] a sub-packaging mechanism installed in the sub-packaging bin, and configured to sub-pack the liquid in the container to be sub-packed into the sub-packaging bag; and

[0010] The liquid path mechanism is installed on the housing, and is used to transfer the liquid in the container to be filled into the filling bag through the filling mechanism.

[0011] The present application uses a liquid circuit mechanism to divide the liquid in the container to be divided into multiple sub-packaging bags through a sub-packaging mechanism, thereby realizing rapid sub-packaging of the liquid, thereby improving the speed of liquid sub-packaging. The present application also controls the temperature in the heat preservation warehouse by a temperature control mechanism by separating the heat preservation warehouse and the sub-packaging warehouse in the casing, and the sub-packaging warehouse can protect the sub-packaging bags and also play a certain heat preservation role, thereby controlling the temperature of the cell preparation within the preset temperature requirement range, avoiding the destruction of the integrity and activity of the cell preparation due to temperature discomfort, and improving the quality of liquid sub-packaging. The present application improves the liquid sub-packaging quality while improving the liquid sub-packaging speed, thereby improving the efficiency of liquid sub-packaging.

[0012] The details of one or more embodiments of the disclosure are set forth in the accompanying drawings and the description below, and other features and advantages of the disclosure will be apparent from the description, the drawings, and the claims. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] The present application is further described below with reference to the accompanying drawings and examples.

[0014] FIG1 is a schematic structural diagram of a liquid packaging device provided in one embodiment of the present application.

[0015] FIG2 is a schematic structural diagram of a temperature control mechanism provided in an embodiment of the present application.

[0016] FIG3 is a schematic structural diagram of a fluid path mechanism provided in an embodiment of the present application.

[0017] FIG4 is a schematic structural diagram of a mixing mechanism provided in an embodiment of the present application.

[0018] FIG5 is a schematic structural diagram of a mixing mechanism provided in yet another embodiment of the present application.

[0019] The reference numerals in the specification are as follows:

[0020] Casing; 110, insulation chamber; 111, container for subpackaging; 120, subpackaging chamber; 121, subpackaging bag; 200, temperature control mechanism; 210, first temperature control component; 211, first temperature adjustment component; 2111, compressor; 2112, evaporator; 212, first heat exchange component; 2121, metal tube; 2122, metal sheet; 220, insulation cotton; 230, insulation board; 240, temperature sensor; 300, subpackaging mechanism; 310, subpackaging bag ;320, filling switch valve; 400, liquid circuit mechanism; 410, quantitative component; 411, quantitative tube; 412, first bubble sensor; 413, second bubble sensor; 420, driving component; 421, first driving pump; 422, first switch valve; 423, third bubble sensor; 424, second driving pump; 425, second switch valve; 500, mixing mechanism; 510, mounting plate; 520, mixing component; 521, linear motion component; 5211, driving wheel; 5212, driven wheel; 5213, motor; 5214, transmission belt; 5215, connecting block; 5216, guide shaft; 5217, linear bearing; 5218, first guide shaft; 5219, second guide shaft; 522, mixing plate; 600, sample container. DETAILED DESCRIPTION

[0021] In order to make the technical problems, technical solutions and beneficial effects solved by this application more clearly understood, this application is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this application and are not intended to limit this application.

[0022] It should be understood that the terms "upper", "lower", "left", "right", "front", "back", "middle", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation of this application.

[0023] As shown in FIG1 and FIG2 , an embodiment of the present application provides a liquid packaging device, comprising:

[0024] The housing 100 includes an insulation chamber 110 for accommodating a container 111 to be packaged and for keeping the container 111 to be packaged warm, and a packaging chamber 120 for accommodating a plurality of packaging bags 310. In this embodiment, as shown in FIG1 , a container 111 to be packaged for accommodating liquid is installed in the insulation chamber 110 on the liquid packaging equipment, and a plurality of packaging bags 310 are installed in the packaging chamber 120. At the same time, only after a consumable tube group for transmitting fluid (including gas and liquid) is installed on the liquid packaging equipment can the liquid in the container 111 to be packaged be packaged. In this embodiment, after the subpackaging operation is completed, the next round of subpackaging operation can be carried out by replacing the consumable tube group, the container to be subpacked 111 and the subpackaging bag 310, or by directly replacing the subpackaging bag 310 (for example, by cutting off the inlet of the subpackaging bag 310 by heat sealing, and then heat-sealing the replaced subpackaging bag 310 to the inlet through a sterile pipe connection machine), thereby improving the subpackaging efficiency. Specifically, the container to be subpacked 111 can be connected to the multiple subpackaging bags 310 in the subpackaging mechanism 300 through the first transmission pipeline in the consumable tube group. After the container to be subpacked 111 is installed in the heat preservation warehouse 110, the multiple subpackaging bags 310 are installed in the subpackaging warehouse 120, and the first transmission pipeline is installed in the liquid circuit mechanism 400, the liquid in the container to be subpacked 111 can be driven by the liquid circuit mechanism 400 to be subpacked through the subpackaging mechanism 300 into the multiple subpackaging bags 310 of the subpackaging mechanism 300.

[0025] The temperature control mechanism 200 includes a first temperature control component 210 installed in the insulation chamber 110 and used to adjust the temperature in the insulation chamber 110; it can be understood that the liquid filling equipment is generally used for filling cell preparations, so the liquid in the container 111 to be filled is generally a cell preparation. In order to avoid destroying the integrity and activity of the cell preparation, the cell preparation needs to be stored within the first preset temperature requirement range. The first temperature control component 210 may include a first temperature regulating member 211 and a first heat exchange member 212 connected to the first temperature regulating member 211. The first temperature regulating member 211 is used to regulate its own temperature. The first heat exchange member 212 is used to exchange heat in the heat preservation chamber 110, thereby regulating the temperature in the heat preservation chamber 110, and further controlling the temperature of the liquid in the container 111 to be dispensed so that it meets the first preset temperature requirement range. The first temperature control component 210 may also include only the first temperature regulating member 211. The first temperature regulating member 211 directly exchanges heat in the heat preservation chamber 110, thereby regulating the temperature in the heat preservation chamber 110, and further controlling the temperature of the liquid in the container 111 to be dispensed so that it meets the first preset temperature requirement range. The first temperature regulating member 211 can adjust the temperature by means of compressor refrigeration or semiconductor refrigeration. In one embodiment, the first temperature regulating member 211 adjusts the temperature by means of compressor refrigeration, so that the temperature can be adjusted more quickly. As shown in Figure 2, the first temperature regulating component 211 may include components such as a compressor 2111 and an evaporator 2112. The specific cooling method can refer to the cooling method of air conditioning, etc., and will not be repeated here. The first heat exchange component 212 may include heat-conducting components such as metal tubes 2121 and / or metal sheets 2122. The first heat exchange component 212 can exchange heat in a contact or non-contact manner. In one embodiment, the first heat exchange component 212 exchanges heat with the liquid in the container to be dispensed 111 by directly contacting the container to be dispensed 111, so that the temperature of the liquid in the container to be dispensed 111 can be adjusted more efficiently.

[0026] The sub-packaging mechanism 300 is installed in the sub-packaging chamber 120 and is used to dispense the liquid in the container 111 to be dispensed into the sub-packaging bag 310. The sub-packaging chamber 120 can protect the sub-packaging bag 310 and also play a certain role in keeping the cell preparation in the sub-packaging bag 310 warm.

[0027] The liquid path mechanism 400 is mounted on the housing 100 , and is used to transfer the liquid in the container 111 to be dispensed into the dispensing bag 310 through the dispensing mechanism 300 .

[0028] The present application is to be packed in the liquid container 111 by the liquid path mechanism 400 through the sub-packaging mechanism 300 into a plurality of sub-packaging bags 310, thereby realizing the rapid sub-packaging of the liquid, thereby improving the speed of liquid sub-packaging. The present application is also by separating the heat preservation warehouse 110 and the sub-packaging warehouse 120 in the casing 100, controlling the temperature in the heat preservation warehouse 110 by the temperature control mechanism 200, and the sub-packaging warehouse 120 can protect the sub-packaging bag 310, and can also play a certain heat preservation effect, thereby controlling the temperature of the cell preparation within the preset temperature requirement range (including the above-mentioned first preset temperature requirement range and the second preset temperature requirement range mentioned later), avoiding the integrity and activity of the cell preparation due to temperature discomfort, and improving the quality of liquid sub-packaging. The present application improves the liquid sub-packaging quality while improving the liquid sub-packaging speed, thereby improving the efficiency of liquid sub-packaging.

[0029] In one embodiment, the temperature control mechanism 200 also includes a second temperature control component (not shown) installed in the sub-packaging bin 120 and used to adjust the temperature in the sub-packaging bin 120. In this embodiment, the temperature of the sub-packaging bag 310 in the sub-packaging bin 120 can be adjusted by installing the second temperature control component in the sub-packaging bin 120, thereby controlling the temperature of the liquid in the sub-packaging bag 310 to meet the second preset temperature requirement range. It can be understood that the second preset temperature requirement range and the first preset temperature range can be the same or different. The first temperature control component 210 and the second temperature control component can respectively adjust the temperature in the heat preservation bin 110 and the sub-packaging bin 120, so that the temperature in the heat preservation bin 110 and the sub-packaging bin 120 respectively meets the first preset temperature requirement range and the second preset temperature requirement range. The second temperature control assembly may include a second temperature regulating member and a second heat exchange member connected to the second temperature regulating member, wherein the second temperature regulating member is used to regulate its own temperature, and the second heat exchange member is used to exchange heat in the sub-packaging chamber 120, thereby maintaining the temperature in the sub-packaging chamber 120, and further maintaining the temperature of the liquid in the sub-packaging bag 310; the second temperature control assembly may also include only the second temperature regulating member, which directly exchanges heat in the sub-packaging chamber 120, thereby maintaining the temperature in the sub-packaging chamber 120, and further controlling the temperature of the liquid in the sub-packaging bag 310. The second temperature regulating member may perform temperature regulation through compressor refrigeration or semiconductor refrigeration. In one embodiment, the second temperature regulating member performs temperature regulation through semiconductor refrigeration, thereby achieving temperature maintenance while saving costs. In one embodiment, the second temperature regulating member exchanges heat with the liquid in the sub-packaging bag 310 by directly contacting the sub-packaging bag 310, thereby more efficiently maintaining the temperature of the liquid in the sub-packaging bag 310.

[0030] In one embodiment, the housing 100 further includes a temperature control channel (not shown) connected between the heat preservation bin 110 and the sub-packaging bin 120; the temperature control mechanism 200 further includes a temperature transmission component (not shown) installed in the temperature control channel and used to control the heat exchange between the heat preservation bin 110 and the sub-packaging bin 120. In this embodiment, the sub-packaging bags 310 in the sub-packaging bin 120 can be kept warm by the temperature transmission component installed in the temperature control channel. The temperature control channel may include an air duct connected between the heat preservation bin 110 and the sub-packaging bin 120, and the temperature transmission component may include a fan provided in the air duct, etc., and then, the fan may drive the cold air in the heat preservation bin 110 into the sub-packaging bin 120, so that the sub-packaging bin 120 meets the second preset temperature requirement range corresponding thereto. By controlling the air volume of the fan or the on / off of the air duct, the amount of cold air in the heat preservation chamber 110 entering the sub-packaging chamber 120 can also be controlled, so that the temperatures in the heat preservation chamber 110 and the sub-packaging chamber 120 meet the first preset temperature requirement range and the second preset temperature requirement range respectively. The temperature control channel can also include a channel connecting the heat preservation chamber 110 and the sub-packaging chamber 120, and the temperature transmission component can include a heat pipe arranged in the channel, etc., and then, the heat pipe can perform heat exchange between the heat preservation chamber 110 and the sub-packaging chamber 120, so that the sub-packaging chamber 120 meets the second preset temperature requirement range corresponding thereto. By controlling the heat conductivity of the heat pipe (such as the flow rate of the refrigerant in the heat pipe, etc.) or on / off, the amount of cold air in the heat preservation chamber 110 entering the sub-packaging chamber 120 can also be controlled, so that the temperatures in the heat preservation chamber 110 and the sub-packaging chamber 120 meet the first preset temperature requirement range and the second preset temperature requirement range respectively.

[0031] In one embodiment of the present application, while the second temperature control component is installed in the filling bin 120, the temperature of the filling bag 310 in the filling bin 120 can be adjusted by the temperature transmission component installed in the temperature control channel, thereby controlling the temperature of the liquid in the filling bag 310 to meet the second preset temperature requirement range. The specific settings can be referred to the description in the above embodiment and will not be repeated here.

[0032] As shown in FIG2 , in one embodiment, the temperature control mechanism 200 further includes heat-insulating cotton 220 covering the inner wall of the heat-insulating bin 110, and a heat-insulating plate 230 mounted on the door of the heat-insulating bin 110; a heat-insulating space for keeping the containers 111 to be dispensed contained in the heat-insulating bin 110 warm is formed between the heat-insulating plate 230 and the heat-insulating cotton 220. It is understandable that the heat-insulating bin 110 includes a door, on which a heat-insulating plate 230 is provided; a heat-insulating space for keeping the containers 111 to be dispensed contained in the heat-insulating bin 110 warm is formed between the heat-insulating plate 230 and the heat-insulating cotton 220. The heat-insulating cotton 220 may be arranged on the inner wall covering part or all of the heat-insulating bin 110. The thermal insulation cotton 220 and the thermal insulation board 230 can block heat exchange between the thermal insulation chamber 110 and the outside world, preventing energy from being dissipated outward, thereby facilitating the cooling of the liquid in the container 111 to be dispensed, thereby improving temperature control efficiency and reducing energy consumption. Furthermore, the chamber door and the thermal insulation board 230 can both be made of a transparent material to facilitate observation of the mixing status of the container 111 to be dispensed.

[0033] In one embodiment, the liquid filling device further includes a heat dissipation component (not shown) disposed on the housing 100 and used to dissipate heat from the temperature control mechanism 200. The heat dissipation component includes a heat dissipation channel disposed on the housing 100, through which the temperature control mechanism 200 can exchange heat with the outside world; the heat dissipation component further includes a fan disposed in the heat dissipation channel and used to discharge the heat generated by the temperature control mechanism 200, and the fan can accelerate the heat exchange between the temperature control mechanism 200 and the outside world. It can be understood that the temperature control mechanism 200 will generate heat while cooling, and the heat dissipation component can transfer the above heat from the inside of the liquid filling device in a timely manner, thereby ensuring the rapid cooling effect of the temperature control mechanism 200.

[0034] In one embodiment, the bottom of the insulation chamber 110 is provided with a drainage trough (not shown) to prevent accumulation of condensed water or water from leakage from the dispensing container 111. A silicone seal is provided at a location corresponding to the chamber door on the insulation chamber 110 to seal the gap between the chamber door and the insulation chamber 110. A fiberglass pad is also provided on the chamber door to isolate the first heat exchange element 212 and the insulation board 230 from direct contact, thereby further preventing the dissipation of energy within the insulation chamber 110.

[0035] As shown in FIG2 , in one embodiment, the temperature control mechanism 200 further includes a temperature sensor 240 disposed within the heat preservation chamber 110 and configured to detect the temperature within the heat preservation chamber 110. It is understood that the temperature sensor 240 is connected to the temperature control mechanism 200 and configured to transmit a temperature data set to the temperature control mechanism 200. The temperature sensors 240 include at least one first temperature sensor 240 disposed within the heat preservation chamber 110 and a second temperature sensor 240 disposed on the first temperature control assembly 210. The real-time temperature includes a first real-time temperature measured by any one of the first temperature sensors 240 and a second real-time temperature measured by the second temperature sensor 240 disposed on the first temperature control assembly 210. In this embodiment, the temperature data set may include only the first real-time temperature measured by the first temperature sensor 240 of the heat preservation chamber 110, or only the second real-time temperature measured by the second temperature sensor 240, or may include both the second real-time temperature and one or more first real-time temperatures, as long as all real-time temperatures in the temperature data set meet the first preset temperature requirement range. In the above-mentioned embodiment of the present application, "meeting the first preset temperature requirement range" may mean that each real-time temperature in the temperature data set reaches the first preset temperature requirement range corresponding thereto, or may mean that the average value of all real-time temperatures reaches the first preset temperature requirement range corresponding thereto. The first preset temperature requirement range may refer to the required temperature range corresponding to the storage of the cell preparation (e.g., 1-25 degrees Celsius).

[0036] As shown in Figure 3, in one embodiment, the liquid circuit mechanism 400 includes a driving component 420 for driving the liquid in the container to be filled 111 to flow into the filling mechanism 300; the driving component 420 includes a first driving pump 421 for driving the liquid in the container to be filled 111 to flow into the filling mechanism 300, a first switch valve 422 for controlling the on-off of the pipeline between the container to be filled 111 and the filling mechanism 300, and a third bubble sensor 423 for real-time monitoring the flow state of the liquid between the container to be filled 111 and the filling mechanism 300; the first driving pump 421, the first switch valve 422 and the third bubble sensor 423 are all installed on the housing 100.

[0037] In this embodiment, the first transmission pipeline is installed on the first driving pump 421, the first switching valve 422, and the third bubble sensor 423. The first driving pump 421 is used to drive the liquid in the container to be filled 111 to flow to the filling mechanism 300 through the first transmission pipeline. The first switching valve 422 is used to control the opening and closing of the first transmission pipeline between the container to be filled 111 and the filling mechanism 300. The third bubble sensor 423 is used to monitor the flow state of the liquid in the first transmission pipeline between the container to be filled 111 and the filling mechanism 300 in real time.

[0038] It is understandable that the first driving pump 421 includes but is not limited to a peristaltic pump or other pump that can drive the flow of fluid. The peristaltic pump used by the first driving pump 421 can be determined according to the packaging capacity of the liquid to be transmitted. For example, in the embodiment shown in Figure 3, the first driving pump 421 includes a large peristaltic pump and a small peristaltic pump; in this way, when the packaging capacity of the liquid to be transmitted is small, a small peristaltic pump can be used, and when the packaging capacity of the liquid to be transmitted is large, a large peristaltic pump can be used. The peristaltic pump transports fluid by alternately squeezing and releasing the elastic delivery hose of the peristaltic pump. The peristaltic pump can rotate forward or reverse to drive the fluid (either gas or liquid) to flow in different directions.

[0039] It is understandable that there may be gas in the consumable tube set when it is used for the first time. When the first driving pump 421 drives the liquid in the container to be sub-packed 111 to flow to the sub-packaging mechanism 300 through the first transmission pipeline, gas may be injected into the sub-packaging bag 310. In addition, there may be a certain amount of gas in the sub-packaging bag 310 before use. Therefore, the first driving pump 421 can also be used to perform a vacuum operation on each of the sub-packaging bags 310 in the sub-packaging mechanism 300, that is, after the first driving pump 421 inputs a preset volume of liquid into the sub-packaging bag 310, it can also extract the air in each of the sub-packaging bags 310 in the sub-packaging mechanism 300 by reversing or other means, thereby improving the sub-packaging effect.

[0040] In one embodiment, the packaging mechanism 300 further includes an air pressure sensor (not shown) connected to the first transmission pipeline and used to detect the air pressure in the first transmission pipeline. Furthermore, the air pressure sensor is connected to the end of the first transmission pipeline away from the container 111 to be packaged. It can be understood that the first transmission pipeline is connected to the packaging bag 310, and the air pressure sensor is arranged on the first transmission pipeline, which can detect the air pressure in the packaging bag 310. When the air in the packaging bag 310 is extracted through the first transmission pipeline, the air pressure of the first transmission pipeline is detected by the air pressure sensor, so that the air extraction condition of the packaging bag 310 and the air tightness of the packaging bag 310 can be detected.

[0041] As shown in FIG1 , in one embodiment, the housing 100 is provided with a mounting portion for mounting a sample container 600; the driving assembly 420 further includes a second driving pump 424 for driving the liquid in the sample container 600 to flow into the container to be dispensed 111, and a second switch valve 425 for controlling the on / off of a pipeline connecting the container to be dispensed 111 or / and the dispensing mechanism 300 to the outside world; the second driving pump 424 and the second switch valve 425 are both mounted on the housing 100; the third bubble sensor 423 is also used to monitor in real time the flow state of the liquid between the sample container 600 and the container to be dispensed 111. The sample container 600 can be a container such as a liquid bag for holding sample liquid (such as various cell preparations that need to be dispensed). It can be understood that before the liquid is packaged, it is first necessary to connect the sample container 600 with the container to be packaged 111 so that the sample liquid greater than or equal to the total packaging capacity (the total packaging capacity is the capacity of the liquid that needs to be packaged into all the packaging bags 310 of the packaging mechanism 300 this time) is input from the sample container 600 into the container to be packaged 111, thereby ensuring that the liquid can be packaged into all the packaging bags 310 of the packaging mechanism 300 and meet the packaging capacity requirements.

[0042] In this embodiment, the sample container 600 is connected to the container to be divided 111 through the second transmission pipeline in the consumable tube group. The container to be divided 111 and / or the filling mechanism 300 are connected to the outside world through the gas pipeline in the consumable tube group. Furthermore, the end of the second transmission pipeline away from the sample container 600 is connected to the first transmission pipeline. The second transmission pipeline is installed on the second driving pump 424, so as to drive the liquid in the sample container 600 to flow into the container to be divided 111. One end of the gas pipeline is connected to the first transmission pipeline, and the gas pipeline is installed on the second switch valve 425, so as to control the on-off of the pipeline connecting the container to be divided 111 and / or the filling mechanism 300 to the outside world.

[0043] It is understandable that the second driving pump 424 includes but is not limited to a peristaltic pump or other pump that can drive the flow of fluid. The peristaltic pump used by the second driving pump 424 can be determined according to the total packaging capacity of the liquid to be transmitted. For example, when the total packaging capacity of the liquid to be transmitted is small, a small peristaltic pump can be used. When the total packaging capacity of the liquid to be transmitted is large, a large peristaltic pump can be used. The peristaltic pump transports fluid by alternately squeezing and releasing the elastic delivery hose of the peristaltic pump. The peristaltic pump can rotate forward or reverse to drive the fluid (either gas or liquid) to flow in different directions.

[0044] As shown in Figures 1 and 3, in one embodiment, the positions for installing pipelines on the first drive pump 421, the first switch valve 422, the third bubble sensor 423, the second drive pump 424 and the second switch valve 425 are all located on the same surface of the casing 100, thereby facilitating operation and use.

[0045] In one embodiment, a sterile filter is provided at one end of the gas pipeline away from the first transmission pipeline, thereby preventing bacteria in the external atmosphere from entering the consumable tube set.

[0046] As shown in Figure 3, in one embodiment, the liquid path mechanism 400 includes a quantitative component 410 for detecting the real-time flow rate of the liquid flowing from the container to be filled 111 into the filling mechanism 300; the quantitative component 410 includes a quantitative tube 411, and a first bubble sensor 412 and a second bubble sensor 413 respectively arranged at both ends of the quantitative tube 411; the quantitative tube 411, the first bubble sensor 412 and the second bubble sensor 413 are all installed on the housing 100.

[0047] In this embodiment, the first transmission pipeline is installed on the first bubble sensor 412, the quantitative tube 411, and the second bubble sensor 413. The quantitative tube 411 can be a container with an internal space or a fixed pipeline. A quantitative space is defined between the first bubble sensor 412 and the second bubble sensor 413. The quantitative space includes the internal space of the quantitative tube 411, the space between the first bubble sensor 412 and the quantitative tube 411, and the space between the quantitative tube 411 and the second bubble sensor 413.

[0048] It is understood that the quantitative component 410 can accurately detect the real-time flow rate of the sample liquid flowing into the dispensing mechanism 300 based on a multi-mode sensor data fusion algorithm, that is, the real-time flow rate of the first driving pump 421. Specifically, detecting the real-time flow rate of the sample liquid flowing into the dispensing mechanism 300 by the quantitative component 410 includes the following steps:

[0049] S10. Detecting the first time point at which liquid flows into a quantitative space by first bubble sensor 412. The quantitative space refers to the flow space in the first transmission pipeline between first bubble sensor 412 and second bubble sensor 413. The quantitative space includes the interior space of quantitative tube 411. In other words, the first time point at which liquid flows from first bubble sensor 412 can be determined by first bubble sensor 412.

[0050] S20 , detecting a second time point at which the liquid flows out of the quantitative space by the second bubble sensor 413 . That is, the second time point at which the liquid flows out of the second bubble sensor 413 can be determined by the second bubble sensor 413 .

[0051] S30, obtaining the spatial capacity of the quantitative space, and determining the real-time flow rate based on the spatial capacity, the first time point, and the second time point. That is, first, the time difference between the first time point and the second time point is obtained, and then the spatial capacity of the quantitative space is divided by the time difference to determine the current real-time flow rate of the first drive pump 421. It is understandable that during the above-mentioned liquid transmission process, if the liquid is a cell preparation, due to the different densities and sizes of different cells in different liquids, the flow rate of the liquid in the first transmission pipeline (the quotient of the real-time flow rate of the first drive pump 421 and the cross-sectional area of ​​the first transmission pipeline) will affect the survival rate of the cells. Therefore, an initial flow rate can be pre-set based on the parameters of the liquid (including the liquid type) and the parameters of the first transmission pipeline (including the cross-sectional area of ​​the first transmission pipeline) so that the liquid flows at the initial speed to ensure cell activity, and then the first drive pump 421 is controlled to operate at the initial flow rate, thereby driving the liquid to flow at the initial speed. However, in the actual liquid transmission process, the first drive pump 421 cannot operate accurately at the initial flow rate, and a certain error is inevitable. Therefore, for this application, it is necessary to determine the capacity of the liquid currently entering the filling mechanism 300 based on the real-time flow rate, and the filling amount of the liquid entering each filling bag 310 during the filling process is closely related to the above-mentioned capacity. Therefore, the actual change of the initial flow rate must be further determined, that is, the real-time flow rate is accurately determined through the above-mentioned quantitative component 410, and then the accuracy of the filling amount of the liquid entering each filling bag 310 can be guaranteed, thereby improving the filling accuracy.

[0052] In one embodiment, the liquid filling equipment further includes a mixing mechanism 500 installed in the heat preservation warehouse 110; the mixing mechanism 500 includes a mounting plate 510 and a mixing component 520; the container 111 to be filled is mounted on the mounting plate 510, and the mixing component 520 is mounted on the mounting plate 510 and is used to mix the liquid in the container 111 to be filled. It can be understood that the above-mentioned mixing process may refer to mixing the liquid in the container 111 to be filled according to pre-set mixing parameters (including but not limited to mixing frequency, mixing amplitude, mixing speed, mixing acceleration, etc.). The mounting plate 510 can be installed on the inner wall of the heat preservation warehouse 110.

[0053] As shown in Figures 4 and 5, in one embodiment, the mixing assembly 520 includes a linear motion assembly 521 mounted on the mounting plate 510, and a mixing plate 522 connected to the linear motion assembly 521 and disposed opposite the container 111 to be dispensed. Driven by the linear motion assembly 521, the mixing plate 522 taps or squeezes the container 111 to be dispensed to mix the liquid in the container 111. It is understood that the mixing plate 522 can be disposed opposite the first temperature control assembly 210, with the container 111 to be dispensed located between the mixing plate 522 and the first temperature control assembly 210. The linear motion component 521 is used to output linear motion to the mixing plate 522, so that the mixing plate 522 squeezes or slaps the container to be filled 111 arranged between the mixing plate 522 and the first temperature control component 210, so that the liquid in the container to be filled 111 flows upward and then sinks. While cooling the liquid in the container to be filled 111, the liquid in the container to be filled 111 can also be mixed.

[0054] As shown in Figures 4 and 5, in one embodiment, a guide hole is provided on the mounting plate 510; the linear motion assembly 521 includes a driving wheel 5211, a driven wheel 5212, a motor 5213 connected to the driving wheel 5211 and used to drive the driving wheel 5211 to rotate, a transmission belt 5214 sleeved on the driving wheel 5211 and the driven wheel 5212, a connecting block 5215 connecting the transmission belt 5214, and a guide shaft 5216 connected to the connecting block 5215; the end of the guide shaft 5216 away from the connecting block 5215 passes through the guide hole and is connected to the mixing plate 522. It can be understood that the motor 5213 is used to drive the driving wheel 5211 to drive the transmission belt 5214 to rotate, and then drive the connecting block 5215, the guide shaft 5216 and the mixing plate 522 to move linearly along the guide hole through the transmission belt 5214, so that the mixing plate 522 approaches or moves away from the bag to be dispensed 310 installed on the mounting plate 510, thereby achieving patting or squeezing of the bag to be dispensed 310, and thus achieving mixing of the liquid in the bag to be dispensed 310.

[0055] As shown in Figures 4 and 5, in one embodiment, the linear motion assembly 521 further includes a linear bearing 5217 sleeved within the guide hole and used for guidance; the guide shaft 5216 is slidably connected to the guide hole via the linear bearing 5217. Furthermore, a ball bearing is provided on the inner wall of the linear bearing 5217. The linear bearing 5217 is disposed between the guide hole and the guide shaft 5216. When the guide shaft 5216 moves in the guide direction within the linear bearing 5217, it can roll with the ball bearing, thereby reducing the frictional force during smooth movement between the guide hole and the guide shaft 5216, thereby reducing heat generation, and at the same time achieving smooth linear motion with high sensitivity and high precision.

[0056] As shown in Figures 4 and 5, in one embodiment, the guide shaft 5216 includes a first guide shaft 5218 and a second guide shaft 5219; one end of the mixing plate 522 is rotatably connected to the first guide shaft 5218, and the other end of the mixing plate 522 is detachably connected to the second guide shaft 5219. In this embodiment, the container 111 to be dispensed is located between the mounting plate 510 and the mixing plate 522. To facilitate the removal and placement of the container 111 to be dispensed, one end of the mixing plate 522 is rotatably connected to the first guide shaft 5218, and the other end of the mixing plate 522 is detachably connected to the second guide shaft 5219. The mixing plate 522 can be detached from the second guide shaft 5219 and then rotated with the first guide shaft 5218, thereby forming a larger access space, thereby further facilitating the removal and placement of the container 111 to be dispensed. It is understood that the rotational connection method includes, but is not limited to, a hinge connection, a bearing connection, or a rotational plug-in connection. Furthermore, one end of the mixing plate 522 is rotatably connected to the first guide shaft 5218 via a torque hinge, thereby maintaining the mixing plate 522 in a fixed position after opening without interfering with the placement of the container 111. Such detachable connection methods include, but are not limited to, snap connections, interference fit connections, or pin connections. Furthermore, the other end of the mixing plate 522 is detachably connected to the second guide shaft 5219 via a knob-type snap, ensuring a more stable connection and easier removal.

[0057] As shown in Figure 1, in one embodiment, the sub-packaging mechanism 300 includes a sub-packaging switch valve 320 that is correspondingly arranged at the entrance of each sub-packaging bag 310 and is used to control the entrance switch of the sub-packaging bag 310. It can be understood that an input pipeline can be set at the entrance of the sub-packaging bag 310, and the sub-packaging switch valve 320 can be set on the input pipeline. After the sub-packaging switch valve 320 is opened, the liquid can flow into the sub-packaging bag 310. After the sub-packaging bag 310 reaches the sub-packaging capacity, the sub-packaging switch valve 320 is closed to ensure that all sub-packaging bags 310 are filled and meet the sub-packaging capacity requirements. In addition, after the sub-packaging operation is completed, the input pipeline can be cut off by heat sealing, and then the replaced sub-packaging bag 310 can be heat-sealed and connected to the sub-packaging pipeline by a sterile pipe connection machine, so that the next round of sub-packaging operation can be carried out.

[0058] The above is only an embodiment of the liquid packaging equipment of the present application and is not intended to limit the present application. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. A liquid packaging device, wherein: include: A casing, wherein a heat preservation chamber for accommodating containers to be packaged and for keeping the containers to be packaged warm, and a packaging chamber for accommodating a plurality of packaging bags are separately arranged in the casing; A temperature control mechanism, comprising a first temperature control component installed in the heat preservation bin and used to adjust the temperature in the heat preservation bin; A sub-packaging mechanism is installed in the sub-packaging bin, and the sub-packaging mechanism is used to pack the liquid in the container to be packed into the sub-packaging bag; as well as A liquid path mechanism is installed on the housing, and is used to dispense the liquid in the container to be dispensed into the dispensing bag through the dispensing mechanism.

2. The liquid dispensing equipment according to claim 1, wherein: The temperature control mechanism also includes a second temperature control component installed in the sub-packaging bin and used for adjusting the temperature in the sub-packaging bin.

3. The liquid dispensing equipment according to claim 1, wherein: The casing also includes a temperature control channel connected between the heat preservation bin and the sub-packaging bin; the temperature control mechanism also includes a temperature transmission component installed in the temperature control channel and used to control the heat exchange between the heat preservation bin and the sub-packaging bin.

4. The liquid dispensing equipment according to claim 1, wherein: The temperature control mechanism further includes heat-insulating cotton wrapped on the inner wall of the heat-insulating bin, and a heat-insulating plate installed on the bin door of the heat-insulating bin; a heat-insulating space is formed between the heat-insulating plate and the heat-insulating cotton for heat-insulating the containers to be packaged contained in the heat-insulating bin; and / or The temperature control mechanism also includes a temperature sensor disposed in the heat preservation chamber and used for detecting the temperature in the heat preservation chamber.

5. The liquid dispensing equipment according to claim 1, wherein: The liquid path mechanism includes a quantitative component for detecting the real-time flow rate of liquid flowing from the container to be filled into the filling mechanism; the quantitative component includes a quantitative tube, and a first bubble sensor and a second bubble sensor respectively arranged at both ends of the quantitative tube; the quantitative tube, the first bubble sensor and the second bubble sensor are all installed on the casing.

6. The liquid dispensing equipment according to claim 1, wherein: The liquid circuit mechanism includes a driving component for driving the liquid in the container to be filled to flow into the filling mechanism; the driving component includes a first driving pump for driving the liquid in the container to be filled to flow into the filling mechanism, a first switch valve for controlling the on-off of the pipeline between the container to be filled and the filling mechanism, and a third bubble sensor for real-time monitoring the flow state of the liquid between the container to be filled and the filling mechanism; the first driving pump, the first switch valve and the third bubble sensor are all installed on the casing.

7. The liquid dispensing equipment according to claim 1, wherein: The liquid filling equipment also includes a mixing mechanism installed in the insulation bin; the mixing mechanism includes a mounting plate and a mixing component; the container to be filled is installed on the mounting plate, and the mixing component is installed on the mounting plate and is used to mix the liquid in the container to be filled.

8. The liquid dispensing equipment according to claim 7, wherein: The mixing component includes a linear motion component installed on the mounting plate, and a mixing plate connected to the linear motion component and arranged opposite to the container to be dispensed; the mixing plate is driven by the linear motion component to slap or squeeze the container to be dispensed to mix the liquid in the container to be dispensed.

9. The liquid dispensing equipment according to claim 8, wherein: A guide hole is provided on the mounting plate; the linear motion assembly includes a driving wheel, a driven wheel, a motor connected to the driving wheel and used to drive the driving wheel to rotate, a transmission belt sleeved on the driving wheel and the driven wheel, a connecting block connecting the transmission belt, and a guide shaft connected to the connecting block; an end of the guide shaft away from the connecting block passes through the guide hole to be connected to the mixing plate.

10. The liquid dispensing equipment according to claim 9, wherein: The linear motion assembly also includes a linear bearing sleeved in the guide hole and used for guiding; the guide shaft is slidably connected to the linear bearing.

11. The liquid dispensing equipment according to claim 9, wherein: The guide shaft includes a first guide shaft and a second guide shaft; one end of the mixing plate is rotatably connected to the first guide shaft, and the other end of the mixing plate is detachably connected to the second guide shaft.

12. The liquid dispensing equipment according to claim 1, wherein: The sub-packaging mechanism includes sub-packaging switch valves which are arranged at the entrances of the sub-packaging bags in a one-to-one correspondence and are used to control the opening and closing of the entrances of the sub-packaging bags.

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