Micro-particle manufacturing method

Abstract

Disclosed is a micro-particle manufacturing method. The micro-particle manufacturing method according to one aspect of the present invention may comprise the steps of: preparing a sheet-type mold in which a plurality of engraved cavities are recessed from the upper surface; applying a certain amount of a raw material onto the upper surface of the sheet-type mold by means of a nozzle of a dispenser; filling the engraved cavities with the raw material by means of the relative horizontal movement of the sheet-type mold or an elastic body of a blading machine in a state in which an end of the elastic body is in elastic contact with the upper surface of the sheet-type mold; providing the sheet-type mold with a heat source from a dryer to dry the raw material filled in the engraved cavities, thereby forming micro particles; and transmitting an external force to the sheet-type mold so that the formed micro particles are separated from the engraved cavities, thereby separating and collecting the micro particles.

Description

Microparticle manufacturing method

[0001] The present invention relates to a method for manufacturing microparticles, and more particularly, to a method for manufacturing microparticles capable of mass-producing microparticles having a plurality of advanced tips formed therein so as to effectively deliver and increase an active ingredient to the skin.

[0002] Generally, drugs and bioactive substances are administered orally in tablet or capsule form, but many drugs cannot be effectively delivered using only the above-mentioned administration method for reasons such as digestion or absorption in the gastrointestinal tract or loss through liver mechanisms.

[0003] Furthermore, some drugs cannot effectively diffuse through the intestinal mucosa, and patient compliance is also a problem. Another common technique for delivering drugs and bioactive substances is the use of conventional needles. While more effective than oral administration, this method has been associated with problems such as pain at the injection site, local skin damage, bleeding, and infection at the injection site.

[0004] To address these issues with oral administration and subcutaneous injection, transdermal administration using patches is utilized. Transdermal administration using patches has fewer side effects, higher patient compliance, and facilitates maintaining consistent blood drug concentrations.

[0005] As one of the transdermal administration methods described above, various microstructures including microneedles have been developed.

[0006] The materials used for the microneedles include metals and various polymers. Recently, biodegradable polymers have been gaining attention as a promising material for microneedles. These microneedles are manufactured in the form of patches equipped with adhesive sheets, which are then attached to the desired area of ​​the body.

[0007] However, these microneedle products were manufactured in the form of patches and could only be used in limited areas of the human body. Furthermore, when the adhesive strength of the adhesive sheet was weak, the effectiveness was very low. Therefore, technology for microparticles emerged as an alternative to patch-type microneedle products.

[0008] (Patent Document 1) KR10-2302311 B1

[0009] Patent Document 1 discloses a method for manufacturing microneedle particles, which sequentially includes the steps of spotting a viscous substance on a sheet, bringing another sheet close to the viscous substance to bring it into contact with the viscous substance, separating the sheets to tension the viscous substance, blowing air on the tensioned viscous substance to solidify the viscous substance, and extracting and collecting microparticles formed on the sheet.

[0010] The present invention is intended to solve the above-mentioned problems, and the purpose of the present invention is to provide a method for manufacturing microparticles capable of mass-producing microparticles having a plurality of advanced tips formed so as to effectively deliver and increase active ingredients to the skin.

[0011] The technical problems to be achieved in the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned can be clearly understood by a person having ordinary skill in the technical field to which the present invention belongs from the description below.

[0012] According to one aspect of the present invention, a method for manufacturing microparticles is provided, comprising: a step of preparing a sheet-shaped mold having a plurality of negative cavities sunken into an upper surface; a step of applying a certain amount of a raw material to an upper surface of the sheet-shaped mold by a nozzle of a dispenser; a step of filling the raw material into the negative cavities by relative horizontal movement of the sheet-shaped mold or an elastic body in a state where an elastic body end of a blading machine is elastically contacted with the upper surface of the sheet-shaped mold; a step of providing a heat source to the sheet-shaped mold from a dryer to dry the raw material filled in the negative cavities to form microparticles; and a step of transmitting an external force to the sheet-shaped mold so as to separate the microparticles formed from the negative cavities and collect the microparticles.

[0013] At this time, the step of applying the raw material may include bringing the nozzle close to the upper surface of one side edge of a sheet-shaped mold that is temporarily stopped and waiting, and then discharging the raw material while moving the nozzle horizontally so that a certain amount of the raw material can be applied in a straight line to one side of the upper surface of the sheet-shaped mold.

[0014] At this time, the step of filling the raw material into the negative cavity can be performed by a process of moving the sheet-shaped mold horizontally relative to a fixed-position elastic body or moving the elastic body horizontally relative to a fixed-position sheet-shaped mold.

[0015] At this time, the step of forming the microparticles may include a drying chamber in which at least one sheet-shaped mold is accommodated internally, and at least one heating rod that generates electric resistance heat when power is applied to the internal space of the drying chamber, thereby providing electric resistance heat to one or both sides of the upper and lower surfaces of the sheet-shaped mold.

[0016] At this time, the step of forming the microparticles may include a drying chamber in which at least one sheet-shaped mold is accommodated internally, and at least one hot air vent for blowing hot air heated by heating air into the internal space of the drying chamber, so as to provide hot air to one or both sides of the upper and lower surfaces of the sheet-shaped mold.

[0017] At this time, after the step of filling the raw material into the negative cavity, a raw material cleaning machine for performing a raw material cleaning process is included, and the raw material cleaning machine includes a cleaning chamber having a winding roll disposed in an internal space on which a cleaning cloth sheet supplied by being unwound from a winding roll is wound, and a cleaning cylinder having a contact member disposed between the unwound roll and the winding roll and provided at a rod end to come into contact with the upper surface of the cleaning cloth sheet impregnated with purified water, and operating up and down so that the lower surface of the cleaning cloth sheet and the upper surface of the sheet-shaped mold come into contact with or are separated from each other, so that the raw material remaining on the upper surface of the sheet-shaped mold can be washed and removed.

[0018] At this time, the step of separating and collecting the micro particles includes an upper brush roll having a brush that selectively contacts the upper surface of the sheet-shaped mold in which the negative cavity is formed, and an upper collection box connected to a vacuum suction source and a communication line, so that the micro particles that are forcibly separated from the negative cavity by frictional force with the brush of the upper brush roll that rotates in one direction can be collected by a vacuum suction force applied to the upper region of the sheet-shaped mold.

[0019] At this time, the step of separating and collecting the micro particles may include an inversion device that inverts the sheet-shaped mold by 180 degrees to cause the micro particles forcibly separated from the negative cavity to fall in the direction of their own weight.

[0020] At this time, the step of separating and collecting the micro particles may include a lower brush roll having a brush that selectively contacts the lower surface of the sheet-shaped mold inverted by the inverting device, and a lower collection box that collects the micro particles that are forcibly separated and dropped from the negative cavity by frictional force between the brush of the lower brush roll that rotates in one direction.

[0021] At this time, the step of separating and collecting the micro particles may include a suction port that applies a vacuum suction force to the lower side of the sheet-shaped mold inverted by the inversion device, and another lower collection box that is connected to the suction port via a connection line and collects the micro particles that are forcibly separated from the negative cavity by the vacuum suction force.

[0022] At this time, after the step of separating and collecting the micro particles, the method may include a step of dissolving the adherent material remaining on the inner surface of the negative cavity and the surface of the sheet-shaped mold by spraying purified water onto the sheet-shaped mold from which the micro particles have been separated and removed; a step of brushing the surface of the sheet-shaped mold to remove the dissolved adherent material by a cleaning brush roll external to the surface; a step of washing the sheet-shaped mold by spraying washing water onto the surface of the sheet-shaped mold from which the adherent material has been removed; and a step of removing and drying the moisture remaining on the surface of the sheet-shaped mold by air forcibly blown toward the sheet-shaped mold.

[0023] It may include microparticles manufactured by the above-described manufacturing method.

[0024] According to the above configuration, the method for manufacturing microparticles according to the present invention can mass-produce microparticles having a plurality of advanced tips formed so as to effectively deliver and increase active ingredients to the skin, and can reduce manufacturing costs and increase price competitiveness by repeatedly reusing a sheet-shaped mold for forming microparticles.

[0025] The skin penetration rate can be increased by using micro particles with multiple cutting-edge tips that increase friction when in contact with the skin, and it can be effectively applied to wrinkled areas or acne areas with curves on the skin.

[0026] The effects of the present invention are not limited to the effects described above, and should be understood to include all effects that can be inferred from the detailed description of the present invention or the composition of the invention described in the claims.

[0027] Figure 1 is an overall schematic diagram illustrating a method for manufacturing microparticles according to an embodiment of the present invention.

[0028] FIG. 2 is a schematic diagram showing the entire system applied to a method for manufacturing microparticles according to an embodiment of the present invention.

[0029] FIG. 3 is a configuration diagram illustrating a mold loader, dispenser, blading machine, and raw material cleaning machine applied to a micro particle manufacturing method according to an embodiment of the present invention.

[0030] Figure 4 is a configuration diagram of a method for manufacturing micro particles according to an embodiment of the present invention, in which a dryer, a converter, a lower brush roll, and a lower collection box are applied.

[0031] Figure 5 is an overall schematic diagram of a micro particle manufacturing method according to an embodiment of the present invention, in which a lower brush roll and a lower collection box are applied.

[0032] Figure 6 is an overall schematic diagram of a method for manufacturing micro particles according to an embodiment of the present invention, in which a dryer, a converter, a suction port, and a lower collection box are applied.

[0033] Hereinafter, with reference to the attached drawings, embodiments of the present invention will be described in detail so that those skilled in the art can easily practice the present invention. The present invention may be implemented in various different forms and is not limited to the embodiments described herein. To clearly explain the present invention, parts irrelevant to the description are omitted in the drawings, and the same reference numerals designate identical or similar components throughout the specification.

[0034] The words and terms used in this specification and claims should not be construed as limited to their ordinary or dictionary meanings, but should be interpreted in a way that is consistent with the technical idea of ​​the present invention, in accordance with the principles by which the inventor can define terms and concepts in order to best explain his or her invention.

[0035] Therefore, the embodiments described in this specification and the configurations illustrated in the drawings correspond to a preferred embodiment of the present invention, and do not represent all of the technical ideas of the present invention, so there may be various equivalents and modified examples that can replace the configuration at the time of filing of the present invention.

[0036] In this specification, terms such as “include” or “have” are intended to describe the presence of a feature, number, step, operation, component, part or combination thereof described in the specification, but should be understood not to exclude in advance the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts or combinations thereof.

[0037] When a component is said to be "in front of," "behind," "above," or "below" another component, this includes not only being placed "in front of," "behind," "above," or "below" the other component in direct contact with it, but also if there is another component intervening therebetween. Furthermore, when a component is said to be "connected" to another component, this includes not only being directly connected to one another, but also being indirectly connected to one another, unless there are special circumstances.

[0038] Hereinafter, a method for manufacturing micro particles according to a preferred embodiment of the present invention will be described with reference to the drawings.

[0039] A method for manufacturing micro particles according to a preferred embodiment of the present invention may include, as shown in FIGS. 1 and 2, a step of preparing a sheet-shaped mold (1), a step of applying a raw material (3), a step of filling the raw material (3), a step of forming micro particles (4), and a step of separating and collecting the micro particles (4).

[0040] Referring to FIGS. 1 and 2, the step of preparing the sheet-shaped mold (1) can be prepared by placing at least one sheet-shaped mold (1) having a plurality of engraved cavities (2) sunken into the upper surface on the upper surface of a transporting device such as a conveyor belt and waiting.

[0041] The above sheet-shaped mold (1) can be made of a resin material in the shape of a roughly square plate with a plurality of engraved cavities (2) sunken and aligned to fit the shape of the microparticles (4) to be molded.

[0042] Such sheet-shaped mold (1) can be manufactured from a material with excellent formability.

[0043] The above sheet-shaped mold (1) can be prepared by arranging a plurality of them at regular intervals in the direction of travel on a conveyor belt.

[0044] At this time, the upper side of the conveyor belt may include a mold loader (10) having a cartridge in which the sheet-shaped molds (1) are loaded in multiple layers in the height direction.

[0045] The sheet-shaped molds (1) loaded into the cartridges provided in the mold loader (10) are individually dropped in the direction of their own weight and placed on the upper surface of the conveyor belt, and then sequentially transported in one direction when the conveyor belt is in operation, so that they can be supplied to the subsequent process.

[0046] Meanwhile, the entrance side of the mold loader (10) may include another conveyor belt that transports a load in which a plurality of sheet-shaped molds (1) are loaded in multiple layers toward the mold loader, and may include a lifter (15) that operates up and down to move a waiting load toward the mold loader.

[0047] Referring to FIGS. 1, 2 and 3, the step of applying the raw material (3) is to apply a certain amount of the raw material (3) by spraying it from a nozzle (21) provided in a dispenser (20) fixedly installed on a frame structure onto one side of the upper surface of the sheet-shaped mold (1).

[0048] A raw material having a viscosity of a certain size is sprayed from the nozzle (21) and applied in a roughly straight line along one edge of the sheet-shaped mold in a direction perpendicular to the direction in which the sheet-shaped mold is advanced, and can then be left to stand by.

[0049] The above dispenser (20) may include a first cylinder (22) for a nozzle that vertically reciprocates up and down a nozzle (21) that is connected to a raw material tank (not shown) with respect to the upper surface of the sheet-shaped mold (1), and a second cylinder (23) for a nozzle that reciprocates the nozzle (21) in a horizontal direction that intersects at a right angle with the direction of movement of the sheet-shaped mold (1).

[0050] It is preferable that the single application amount of the raw material (3) applied to one side of the upper surface of the sheet-shaped mold (1) be set to approximately 150% of the total volume of the multiple negative cavities (2) formed in the sheet-shaped mold.

[0051] Accordingly, by lowering the first cylinder for the nozzle, the nozzle of the dispenser is brought close to the upper surface of one side edge of the sheet-shaped mold that is temporarily stopped and waiting, and then by horizontally moving the nozzle of the dispenser by horizontally operating the second cylinder for the nozzle, the raw material is discharged through the nozzle, thereby preparing a fixed amount of the raw material by applying it in a straight line to one side of the upper surface of the sheet-shaped mold.

[0052] Continuously, the sheet-shaped mold prepared by applying the above raw material in a straight line on one side of the upper surface can be horizontally transferred to the blading machine side so that the blading process, which is a post-process, can be performed.

[0053] Meanwhile, the raw material (3) is a raw material solution of micro particles (4) to be molded, and this raw material solution includes a biodegradable composition, and a functional material may be mixed into the biodegradable composition.

[0054] The biodegradable composition includes hyaluronic acid and its salts, polyvinylpyrrolidone, polyvinyl alcohol, cellulose polymer, dextran, gelatin, glycerin, polyethylene glycol, polysorbate, propylene glycol, povidone, carbomer, gum ghatti, guar gum, glucomannan, glucosamine, dammer resin, rennet casein, locust bean gum, microfibrillated cellulose, psyllium seed gum, xanthan gum, arabino galactan, gum arabic, alginic acid, gelatin, gellan gum, carrageenan, karaya gum, curdlan, chitosan, chitin, tara gum, Tamarind gum, tragacanth gum, furcelleran, pectin or pullulan may be used.

[0055] The functional material may include a material that penetrates into the skin and performs a specific function such as a pharmacological effect, such as a chemical drug, a protein drug, a peptide drug, a peptide drug for gene therapy, a nucleic acid molecule for gene therapy, and a nanoparticle cosmetic ingredient (e.g., an anti-wrinkle agent, an anti-aging agent, and a skin whitening agent).

[0056] Referring to FIGS. 1, 2 and 3, the step of filling the raw material into the negative cavity (2) is such that the end of the elastic body (31), which is a blader provided in the blading machine (30), is elastically brought into contact with one edge of the upper surface of the sheet-shaped mold (1), and then, in this state of contact, the raw material (3) prepared in a straight line on one edge of the upper surface of the sheet-shaped mold (1) can be filled into each of the plurality of negative cavities (2) formed by recessing in the upper surface of the sheet-shaped mold (1) by the scraping movement of the elastic body (31) due to the relative horizontal movement of the sheet-shaped mold (1) or the elastic body (31).

[0057] The above blading machine (30) may include a holder (32) that supports the elastic body (31) at a predetermined angle with respect to the upper surface of the sheet-shaped mold, and may include a blading cylinder (33) that vertically moves the holder (32) up and down with respect to the upper surface of the sheet-shaped mold (1) so that an end of the elastic body comes into contact with or is spaced apart from the upper surface of the sheet-shaped mold (1).

[0058] The above elastic body (31) may be made of a rubber material having a roughly plate-shaped shape having a length corresponding to the formation area of ​​a plurality of negative cavities (2) sunken into the sheet-shaped mold (1).

[0059] In addition, it is preferable that the elastic body (31) replaceably provided in the holder (32) is arranged at a certain angle so as to be in elastic contact with the upper surface of the sheet-shaped mold (1).

[0060] At this time, the process of filling the raw material into the negative cavity (2) of the sheet-shaped mold (1) can be performed by a process of moving the sheet-shaped mold (1) horizontally relative to a fixed elastic body (31) or by a process of moving the elastic body (31) horizontally relative to a fixed sheet-shaped mold (1).

[0061] Accordingly, when the sheet-shaped mold is moved relative to the elastic body fixed in one direction while the end of the elastic body is elastically brought into contact with one edge of the upper surface of the sheet-shaped mold on which the raw material is applied in a straight line, the raw material that is bladed by the scraping movement of the end of the elastic body can be filled into the engraved cavity of the sheet-shaped mold.

[0062] In addition, any excess raw material remaining on the upper side edge of the sheet-shaped mold can be scraped off by a separate scraper or transferred to one side of a subsequent sheet-shaped mold and reused.

[0063] Referring to FIGS. 1, 2 and 4, the step of forming the micro particles (4) is to provide a heat source to the sheet-shaped mold (1) accommodated inside the dryer (50) to dry and solidify the raw material (3) filled in the negative cavity (2), thereby forming the micro particles (4) corresponding to the shape of the negative cavity (2).

[0064] At this time, the heating source (53) that provides the heat source may be equipped with at least one heating rod that generates heat when power is supplied and generates electric resistance heat to transfer it as radiant heat, or may be equipped with at least one hot air vent that blows hot air that has been heated to a high temperature by heating the air in the atmosphere.

[0065] That is, the dryer (50) that performs the process of forming the above micro particles (4) includes a drying chamber (51) in which at least one sheet-shaped mold (1) is placed and received, and includes at least one heating source (53) such as a heating rod that generates electric resistance heat when power is supplied to the internal space of the drying chamber (51), thereby providing a heat source such as electric resistance heat to one or both sides of the upper and lower surfaces of the sheet-shaped mold (1), thereby drying the raw material (3) filled in the negative cavity (2) and forming and manufacturing solidified micro particles (4).

[0066] In addition, the dryer (50) that performs the process of forming the above micro particles (4) includes another heating source (53), such as at least one hot air vent, that forcibly blows hot air heated to a high temperature from the outside into the internal space of the drying chamber (51), and provides a heat source, such as hot air, to one or both sides of the upper and lower surfaces of the sheet-shaped mold (1), thereby drying the raw material (3) filled in the negative cavity (2) and forming and manufacturing solidified micro particles (4).

[0067] At this time, the drying chamber (51) may include a conveyor belt-like transport device that moves in one direction a plurality of sheet-shaped molds (1) in which a raw material to be bladed is filled in a negative cavity by the scraping movement of the end of the elastic body (31), and the sheet-shaped molds (1) in which the filled raw material is dried and microparticles are formed.

[0068] This drying chamber (51) includes an inlet through which the sheet-shaped mold (1) enters the inner space, and an exit through which the sheet-shaped mold with the dried raw material exits the outer space. The inlet and exit may include a process for drying and forming the raw material (3) filled in the negative cavity (2), and a gate that is selectively opened and closed when the sheet-shaped mold enters and exits.

[0069] Meanwhile, referring to FIGS. 2 and 3, a raw material cleaning machine (40) that performs a raw material cleaning process for washing and removing raw material remaining on the upper surface of the sheet-shaped mold (1) during blading by the elastic body may be additionally included between a blading machine (30) that performs a process of filling raw material (3) into the negative cavity (2) of the sheet-shaped mold (1) and a dryer (50) that performs a process of forming the micro particles (4).

[0070] This raw material cleaning machine (40) includes a cleaning chamber (46) in which a winding roll (43) is arranged in an internal space, on which a cleaning cloth sheet (41) supplied by being unwound from a winding roll (42) is wound, and a contact member (45) is provided at the rod end to contact the upper surface of the cleaning cloth sheet (41) impregnated with purified water, and may include a cleaning cylinder (44) that operates up and down so that the lower surface of the cleaning cloth sheet (41) and the upper surface of the sheet-shaped mold (1) are in contact with or separated from each other.

[0071] Accordingly, when the cleaning cylinder is lowered, the cleaning cloth sheet that comes into contact with the contact member is placed on a conveying device such as a conveyor belt and moves in one direction, so that the raw material remaining on the upper surface of the sheet-shaped mold during the blading process using the elastic body is removed by the cleaning cloth sheet impregnated with purified water, and the sheet-shaped mold from which the raw material remaining on the upper surface has been removed is transferred to a dryer, which is a post-process, so that a molding process using the dryer can be performed.

[0072] In the above cleaning chamber, the contaminated cleaning cloth sheet can be moved to a position so as not to be reused by the synchronized unwinding operation of the unwinding roll and the winding operation of the winding roll.

[0073] In addition, although the process of removing the raw material remaining on the upper surface of the sheet-shaped mold during the blading process by using a cleaning cloth sheet impregnated with purified water is described and illustrated, it is not limited thereto, and a detachable protective film may be applied to the upper surface of the sheet-shaped mold so that no raw material remains on the upper surface of the sheet-shaped mold during the blading process.

[0074] That is, in the step of preparing a sheet-shaped mold (1) prior to the step of applying the raw material (3), a protective film (not shown) having multiple through-holes that correspond one-to-one with the engraved cavities (2) of the sheet-shaped mold (1) and are coincident with each other is temporarily attached to the upper surface of the sheet-shaped mold and prepared together with the sheet-shaped mold.

[0075] Next, a raw material is applied in a straight line to one edge of the protective film by the nozzle (21) of the dispenser, and then a blading process is performed to fill the negative cavity (2) with the raw material (3) while the end of the elastic body (31) is elastically contacted to one edge of the protective film.

[0076] In this case, the raw material is filled in the negative cavity (2) of the sheet-shaped mold (1) that corresponds one-to-one to the through-hole of the protective film, while the raw material is not left on the upper surface of the sheet-shaped mold (1), and the protective film with the remaining raw material is separated and removed from the upper surface of the sheet-shaped mold (1) after the blading process by the elastic body (31), and the sheet-shaped mold (1) from which the protective film has been removed can be transferred to the dryer side, which is a post-process.

[0077] Referring to FIGS. 1 and 2, the step of separating and collecting the micro particles (4) is to forcibly separate and collect the micro particles (4) formed by filling and molding the negative cavity of the sheet-shaped mold (1) from the negative cavity (2) by transmitting an external force to the sheet-shaped mold (1), thereby forcibly separating and collecting the micro particles (4) formed from the negative cavity (2) of the sheet-shaped mold (1).

[0078] That is, the step of separating and collecting the micro particles (4) may include at least one upper brush roll (61) having a brush that selectively contacts the upper surface of a sheet-shaped mold (1) that forms a negative cavity (2) in which the micro particles (4) are formed, and is connected to a vacuum suction source such as a suction motor (not shown) that generates a vacuum suction force when power is applied via a communication line (62), and may include an upper collection box (63) that applies a vacuum suction force to an upper area of ​​the sheet-shaped mold (1) in which the upper brush roll (61) is placed.

[0079] The upper brush roll (61) that is driven in one direction when power is supplied may include a roll member that generates a frictional force to forcibly separate and detach the micro particles (4) from the negative cavity (2) by having multiple brush ends contact the upper surface of the sheet-shaped mold (1) and the micro particles (4) of the negative cavity (2).

[0080] This upper brush roll (61) can be moved up and down or horizontally moved relative to the sheet-shaped mold (1) in which the end of the brush forms the negative cavity (2) by a separate actuator such as a separate cylinder member so that it is selectively brought into contact with or spaced apart from the upper surface of the sheet-shaped mold (1).

[0081] The upper collection box (63) may include a box-shaped structure in which the lower part corresponding to the sheet-shaped mold is open, and the upper brush roll (61) is placed on the open lower part that entirely covers the upper surface of the sheet-shaped mold, thereby forcibly sucking and collecting micro particles (4) forcibly separated from the negative cavity (2) by a vacuum suction force.

[0082] The upper collection box (63) can be moved up and down by a separate actuator such as a cylinder member so that the open lower portion of the upper collection box (63) is brought as close to or away from the upper surface of the sheet-shaped mold (1) as possible, and the open lower end edge of the upper collection box (63) can include a pleated skirt portion that elastically contacts the upper surface of the sheet-shaped mold (1).

[0083] In addition, the conveyor belt on which the sheet-shaped mold (1) for separating and collecting the molded micro particles (4) is placed may include a separate holder device that fixes the sheet-shaped mold (1) so that it does not move in position due to friction with the upper brush roll (61) or vacuum suction applied from the upper collection box (63).

[0084] Accordingly, micro particles are forcibly separated from the negative cavity by frictional force between the brush of the upper brush roll and the upper surface of the sheet-shaped mold in which the negative cavity is formed and the brush of the upper brush roll that is rotated in one direction, and the forcibly separated micro particles can be collected by vacuum suction force of the upper collection box applied to the upper area of ​​the sheet-shaped mold.

[0085] Meanwhile, the process of separating and collecting micro particles (4) from the negative cavity (2) can be performed by simultaneously applying frictional force and vacuum suction force to the sheet-shaped mold (1) while the surface of the sheet-shaped mold (1) in which the negative cavity is formed is set as the upper surface, but is not limited thereto, and can be performed by applying only one external force among the frictional force and vacuum suction force to the sheet-shaped mold while the surface of the sheet-shaped mold (1) in which the negative cavity (2) is formed is set as the lower surface.

[0086] Referring to FIGS. 4 and 5, the step of separating and collecting the micro particles (4) may include an inversion device (55) that inverts the sheet-shaped mold (1) that forms the negative cavity (2) in which the micro particles (4) are formed by 180 degrees so that the micro particles (4) that are forcibly separated from the negative cavity (2) by frictional force or suction force of a brush fall in the direction of their own weight.

[0087] The step of separating and collecting the above micro particles (4) can be performed by inverting the sheet-shaped mold by 180 degrees using the inversion device (55) so that the surface of the sheet-shaped mold in which the negative cavity (2) is formed is turned to the lower side, and then separating and collecting the micro particles (4) by frictional force.

[0088] It may include a lower brush roll (61a) having a brush that selectively contacts the lower surface of the sheet-shaped mold (1) inverted by the above-mentioned inversion device (55), and a lower collection box (65) that collects micro particles (4) that are forcibly separated from the negative cavity (2) and fall in the direction of their own weight by frictional force generated due to contact with the brush of the lower brush roll (61a) that rotates in one direction when power is applied.

[0089] The lower brush roll (61a) that is driven in one direction when power is supplied may, like the upper brush roll (61), include a roll member that generates a frictional force to forcibly separate and detach the micro particles (4) from the negative cavity (2) by having multiple brush ends contact the lower surface of the sheet-shaped mold (1) and the micro particles (4) of the negative cavity (2).

[0090] This lower brush roll (61a) can be moved up and down or horizontally moved relative to the sheet-shaped mold (1) in which the end of the brush forms a negative cavity (2) by a separate actuator such as a separate cylinder member, so that it selectively comes into contact with or is spaced apart from the lower surface of the sheet-shaped mold (1).

[0091] The lower collection box (65) may include a box-shaped structure in which the upper part corresponding to the sheet-shaped mold is open and the lower part is opened to cover the entire lower surface of the sheet-shaped mold, thereby collecting micro particles (4) that are forcibly separated and dropped from the negative cavity (2).

[0092] The lower collection box (65) can be moved up and down by a separate actuator such as a cylinder member so that the open upper portion of the lower collection box (65) is as close to or as far away from the lower surface of the sheet-shaped mold (1) as possible, and the open upper edge of the lower collection box (65) can include a pleated skirt portion that elastically contacts the lower surface of the sheet-shaped mold (1).

[0093] In addition, a separate holder device may be included to fix the inverted sheet-shaped mold (1) so that it does not move in position due to friction with the lower brush roll (61a).

[0094] The above lower collection box (65) may include a storage box (64) for temporarily storing a large amount of collected micro particles.

[0095] In addition, referring to FIG. 6, the step of separating and collecting the micro particles (4) may include at least one suction port (66) that is connected to a vacuum suction source to transmit suction force generated when power is applied to the lower side of the sheet-shaped mold (1) inverted by the inversion device (55), and may include another lower collection box (67) that is connected to the suction port (66) via a connection line (66a) to collect the micro particles (4) that are forcibly separated from the negative cavity (2) by the vacuum suction force.

[0096] And, the upper side of the upper collection box (63) or the lower collection box (65) may include another mold loader (10a) having a cartridge in which the sheet-shaped mold (1) from which the micro particles (4) are separated is loaded in multiple layers in the height direction, and another lifter (15a) that operates up and down to load the sheet-shaped mold (1) from which the micro particles (4) are separated toward the other mold loader (10a) may be included.

[0097] Accordingly, the sheet-shaped mold containing the micro particles formed by drying the raw material filled in the dryer is transferred to the inversion device, and then the sheet-shaped mold is inverted 180 degrees by the inversion device so that the surface of the sheet-shaped mold forming the negative cavity becomes the lower surface.

[0098] Next, the molded micro particles can be forcibly separated from the negative cavity by the frictional force generated between the lower surface of the inverted sheet-shaped mold and the brush of the brush roll that rotates in one direction in contact with the outer surface or by the vacuum suction force applied to the lower surface of the inverted sheet-shaped mold, and the forcibly separated micro particles can be collected by dropping them in the direction of their own weight.

[0099] Meanwhile, referring to FIGS. 1, 5, and 6, after the process of separating and collecting micro particles (4) by friction or suction from the negative cavity (2) of the sheet-shaped mold (1), the process may include a step of dissolving the adhered material, a brushing step, a washing step, and a drying step so that the sheet-shaped mold (1) can be reused repeatedly.

[0100] The step of dissolving the above-mentioned adherent can dissolve the adherent remaining on the inner surface of the negative cavity (2) or the surface of the sheet-shaped mold (1) by spraying purified water from a purified water spray nozzle (70) onto the upper or lower surface of the sheet-shaped mold (1) from which the micro particles (4) have been separated and removed.

[0101] Next, the brushing step is performed by selectively rotating the cleaning brush roll (80) in one direction when power is applied to the upper or lower surface of the sheet-shaped mold (1) onto which the purified water is sprayed, thereby removing the dissolved adhering matter from the inner surface of the engraved cavity (2) or the surface of the sheet-shaped mold (1) by brushing it with the brush of the cleaning brush roll (80).

[0102] The above-mentioned washing step can wash the surface of the sheet-shaped mold (1) by spraying washing water through a washing water spray nozzle (70a) onto the upper or lower surface of the sheet-shaped mold (1) from which dissolved adherents have been removed by brushing with the brush of the washing brush roll (80).

[0103] Finally, the drying step can be performed by forcibly blowing air by a blower (90) to the upper or lower surface of the sheet-shaped mold (1) where some of the washing water remains, thereby removing moisture remaining on the surface of the sheet-shaped mold (1) so that the sheet-shaped mold can be reused.

[0104] At this time, the air forcibly blown toward the sheet-shaped mold (1) by the blower (90) may be cold air at room temperature or hot air having a temperature relatively higher than room temperature.

[0105] The micro particle (4) molded in the negative cavity (2) of the above sheet-shaped mold includes a main body integrally formed with an upper tip in the shape of a square pyramid on the upper part of a polygonal body having a triangular outer surface, and may include a plurality of lateral tip tips in the shape of a triangular pyramid that extend outward from a triangular surface formed on the outer surface of the polygonal body.

[0106] Accordingly, the upper tip and multiple lateral tip tips of the microparticles having a geometric shape can increase the penetration efficiency into the skin when they come into contact with a curved skin area such as a wrinkle.

[0107] Although the embodiments of the present invention have been described, the spirit of the present invention is not limited to the embodiments presented in this specification, and those skilled in the art who understand the spirit of the present invention will be able to easily propose other embodiments by adding, changing, deleting, or adding components within the scope of the same spirit, but this will also be considered to fall within the spirit of the present invention.

[0108] <Explanation of symbols>

[0109] 1: Sheet-shaped mold 2: Engraved cavity

[0110] 3: Raw material 4: Micro particles

[0111] 20: Dispenser 21: Nozzle

[0112] 22: First cylinder for nozzle 23: Second cylinder for nozzle

[0113] 30: Blade 31: Elastic

[0114] 32: Holder 40: Raw material cleaning machine

[0115] 41: Cleaning cloth sheet 42: Unwinding roll

[0116] 43: Winding roll 44: Cleaning cylinder

[0117] 50: Dryer 51: Drying chamber

[0118] 61: Upper brush roll 61a: Lower brush roll

[0119] 62: Flue line 63: Upper collection box

[0120] 65: Lower collection box 66: Intake

[0121] 70: Purified water spray nozzle 70a: Washing water spray nozzle

[0122] 80: Cleaning brush roll 90: Blower

Claims

1. A step of preparing a sheet-shaped mold having multiple negative cavities sunken into the upper surface; A step of applying a certain amount of raw material to the upper surface of the sheet-shaped mold by means of a nozzle of a dispenser; A step of filling a raw material into the negative cavity by relative horizontal movement of the sheet-shaped mold or the elastic body while the elastic end of the blading machine is elastically contacted with the upper surface of the sheet-shaped mold; A step of providing a heat source from a dryer to the sheet-shaped mold to dry the raw material filled in the negative cavity to form micro particles; and A method for manufacturing microparticles, comprising: a step of transmitting an external force to the sheet-shaped mold so as to separate the microparticles formed from the negative cavity, thereby separating and collecting the microparticles.

2. In paragraph 1, The step of applying the above raw material is: A method for manufacturing micro particles, wherein the nozzle is brought close to the upper surface of one edge of a sheet-shaped mold that is paused and waiting, and then the nozzle is moved horizontally to discharge a raw material so that a certain amount of the raw material is applied in a straight line to one side of the upper surface of the sheet-shaped mold.

3. In paragraph 1, The step of filling the raw material into the above engraved cavity is: A method for manufacturing microparticles, which is performed by a process of relatively moving the sheet-shaped mold in a horizontal direction with respect to a fixed elastic body or relatively moving the elastic body in a horizontal direction with respect to a fixed sheet-shaped mold.

4. In paragraph 1, The step of forming the above micro particles is: A method for manufacturing microparticles, comprising: a drying chamber in which at least one sheet-shaped mold is accommodated internally; and at least one heating rod that generates electric resistance heat when power is supplied to the internal space of the drying chamber, thereby providing electric resistance heat to one or both sides of the upper and lower surfaces of the sheet-shaped mold.

5. In paragraph 1, The step of forming the above micro particles is: A method for manufacturing microparticles, comprising: a drying chamber in which at least one sheet-shaped mold is accommodated internally; and at least one hot air vent for blowing hot air heated by heating air into the internal space of the drying chamber, thereby providing hot air to one or both sides of the upper and lower surfaces of the sheet-shaped mold.

6. In paragraph 1, After the step of filling the raw material into the above engraved cavity, Includes a raw material cleaning machine that performs a raw material cleaning process, The above raw material cleaning machine comprises a cleaning chamber having a winding roll in its internal space, on which a cleaning cloth sheet supplied by unwinding from a winding roll is wound, and a cleaning cylinder having a contact member provided at a rod end to come into contact with the upper surface of the cleaning cloth sheet impregnated with purified water and arranged between the unwinding roll and the winding roll, and which operates up and down so that the lower surface of the cleaning cloth sheet and the upper surface of the sheet-shaped mold come into contact with or are separated from each other, thereby washing and removing raw materials remaining on the upper surface of the sheet-shaped mold.

7. In paragraph 1, The step of separating and collecting the above micro particles is: A method for manufacturing micro particles, comprising: an upper brush roll having brushes selectively contacting the upper surface of a sheet-shaped mold in which the negative cavity is formed; and an upper collection box connected to a vacuum suction source and a communication line via a vacuum suction source, wherein micro particles forcibly separated from the negative cavity by frictional force with the brushes of the upper brush roll that rotates in one direction are collected by a vacuum suction force applied to the upper area of ​​the sheet-shaped mold.

8. In paragraph 1, The step of separating and collecting the above micro particles is: A method for manufacturing micro particles, comprising an inversion device that inverts the sheet-shaped mold by 180 degrees to cause micro particles to fall in the direction of their own weight and be forcibly separated from the negative cavity.

9. In paragraph 8, The step of separating and collecting the above micro particles is: A method for manufacturing micro particles, comprising: a lower brush roll having a brush that selectively contacts the lower surface of a sheet-shaped mold inverted by the inverting device; and a lower collection box that collects micro particles that are forcibly separated and dropped from the negative cavity by frictional force with the brush of the lower brush roll that rotates in one direction.

10. In paragraph 8, The step of separating and collecting the above micro particles is: A method for manufacturing micro particles, comprising: a suction port for applying vacuum suction force to the lower surface of a sheet-shaped mold inverted by the inverting device; and another lower collection box connected to the suction port via a connecting line to collect micro particles forcibly separated from the negative cavity by the vacuum suction force.

11. In any one of paragraphs 1 to 10, After the step of separating and collecting the above micro particles, A step of dissolving the remaining adherent material on the inner surface of the negative cavity and the surface of the sheet-shaped mold by spraying purified water onto the sheet-shaped mold from which the above micro particles have been separated and removed; A step of brushing to remove dissolved adherents by a cleaning brush roll externally attached to the surface of the above sheet-shaped mold; A step of washing the sheet-shaped mold by spraying washing water on the surface of the sheet-shaped mold from which the adhesive has been removed; and A method for manufacturing micro particles, comprising: a step of removing moisture remaining on the surface of the sheet-shaped mold by forcibly blowing air toward the sheet-shaped mold to dry it.

12. Microparticles manufactured by any one of the manufacturing methods of clauses 1 to 10.

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