Oxygen-blending nitric oxide therapeutic device and flow control system

Abstract

The present disclosure relates to the field of medical devices, and in particular, to an oxygen-blending nitric oxide therapeutic device and a flow control system. The flow control system comprises a NO inlet module, an O2 inlet module, a constant pressure module, a filtering module, a flow rate control module, an O2 and NO blending module, a gas content sensing module, and an output assembly. An output end of the NO inlet module and an output end of the O2 inlet module are both connected to an input end of the flow rate control module. An output end of the flow rate control module is connected to an input end of the O2 and NO blending module. An output end of the O2 and NO blending module is connected to an input end of the gas content sensing module. An output end of the gas content sensing module is connected to an input end of the output assembly. The gas content sensing module is used for detecting the content of the components O2, NO, and NO2. When the contents of the components O2, NO, and NO2 are all less than or equal to threshold values, a switch of the output assembly is activated. The flow control system can ensure that the patient receives accurate concentrations of gases.

Description

A mixed oxygen nitric oxide therapeutic device and flow control system Technical Field

[0001] The present invention relates to the technical field related to medical devices, and in particular to a mixed oxygen nitric oxide therapeutic device and a flow control system. Background Art

[0002] Cardiovascular disease is a serious health hazard and one of the leading causes of death. It also causes disability in tens of thousands of people each year. Pulmonary hypertension is a common complication in patients with critical cardiovascular disease and remains a major challenge in its treatment.

[0003] In 1991, Fratacci et al. demonstrated in an animal model of pulmonary hypertension that inhaled low-concentration nitric oxide (NO) could reduce pulmonary artery pressure. Because of its highly selective pulmonary vasodilation, NO is becoming an increasingly important treatment for patients with combined respiratory distress syndrome (RDS) and PH. Inhaled NO therapy can reduce the use of extracorporeal membrane oxygenation (ECMO) by 80% and significantly reduce mortality. Despite the inherent risks of low-concentration NO therapy, the US Food and Drug Administration (FDA) approved its use in the clinical treatment of patients with combined PH and RDS in 1999, after more than seven years of research.

[0004] At present, the risks of inhaled nitric oxide therapy include: the safe concentration range of NO is very small, it is easy to combine with hemoglobin to produce methemoglobin, it is very easy to be oxidized into nitrogen dioxide (NO2) and cause pulmonary edema, sudden interruption of inhalation will produce withdrawal reaction, and NO is harmful to the environment and medical staff. In general, reasonable control of the relative concentrations of oxygen and nitric oxide is one of the very important indicators of mixed oxygen nitric oxide therapy devices.

[0005] However, existing mixed oxygen flow control systems are all used in connection with a ventilator and cannot be used in connection with a nasal cannula or mask alone. In addition, it is difficult to accurately control the gas flow rate, and it is difficult to evenly mix oxygen and nitric oxide, detect the gas content, and provide safety protection functions, thereby reducing the stability and reliability of treatment, resulting in difficulty in ensuring that patients obtain accurate gas concentrations, thereby reducing the operability of the system. Therefore, a mixed oxygen nitric oxide therapy device and flow control system are proposed to solve the above technical problems.

[0006] Summary of the Invention

[0007] The present application provides a mixed oxygen nitric oxide therapy device and a flow control system. After mixing nitric oxide with oxygen, the device can be disconnected from a ventilator and connected to a nasal cannula or mask for use alone to ensure that the patient obtains an accurate gas concentration.

[0008] The present application provides a mixed oxygen nitric oxide therapeutic device and flow control system, which adopts the following technical solutions:

[0009] A mixed oxygen type nitric oxide therapeutic device and flow control system, wherein the mixed oxygen type flow control system includes a NO intake module, an O2 intake module, a flow rate control module, an O2 and NO mixing module, a gas content sensor module and an output component;

[0010] The output end of the NO intake module and the output end of the O2 intake module are both connected to the input end of the flow rate control module, the output end of the flow rate control module is connected to the input end of the O2 and NO mixing module, the output end of the O2 and NO mixing module is connected to the input end of the gas content sensor module, and the output end of the gas content sensor module is connected to the input end of the output component. The gas content sensor module is used to detect the content of each component of O2, NO and NO2. When the content of each component of O2, NO and NO2 is less than or equal to a threshold value, the switch of the output component is started.

[0011] By adopting the above technical solution, the flow control system of the mixed oxygen nitric oxide therapy device improves the stability and reliability of treatment by accurately controlling the gas flow rate, evenly mixing the gas, detecting the gas content and providing safety protection functions, ensuring that the patient obtains the accurate gas concentration, while ensuring the patient's safety and improving the operability of the system.

[0012] Preferably, the gas content sensing module includes an O2 content sensing component, a NO content sensing component and a NO2 content sensing component.

[0013] By adopting the above technical solution, the O2 content sensing component, NO content sensing component and NO2 content sensing component of the gas content sensing module can monitor gas content in real time, provide accurate measurement results and safety protection, help adjust treatment parameters, and record and analyze data, thereby improving the safety and effectiveness of treatment.

[0014] Preferably, a filter module is further included, and the filter module is arranged between the output end of the NO intake module and the input end of the flow rate control module.

[0015] By adopting the above technical solution, the filter module is set between the output end of the NO intake module and the input end of the flow rate control module, which can filter impurities, protect patients, improve treatment effects, and provide convenient replacement and maintenance.

[0016] Preferably, the output end of the gas content sensor module is also connected to an alarm component, and when the content of any one of the components of O2, NO and NO2 is greater than a threshold value, the switch of the alarm component is activated.

[0017] By adopting the above technical solution, the output of the gas content sensor module is connected to the alarm component, and a threshold is set. When the gas content exceeds the threshold, the alarm component is activated, providing timely warnings, safety protection, prevention of excessive concentrations, maintenance reminders, and data recording and analysis functions. These functions help ensure the safety and effectiveness of treatment.

[0018] Preferably, based on the above-mentioned mixed oxygen flow control system, the mixed oxygen nitric oxide therapeutic device includes a shell and a three-way pipe arranged in the shell, the three-way pipe is provided with a first interface, a second interface and a third interface, the shell is provided with an O2 inlet pipe and a NO inlet pipe, one end of the O2 inlet pipe is connected to a first flow rate controller, one end of the NO inlet pipe is connected to a second flow rate controller, the output end of the first flow rate controller is connected to the first interface of the three-way pipe, the output end of the second flow rate controller is connected to the second interface of the three-way pipe, the third interface of the three-way pipe is connected to a gas content sensor, and the output end of the gas content sensor is connected to an output pipe.

[0019] By adopting the above technical solutions, through precise mixed gas control and safety monitoring, O2, NO and NO2 that meet the set requirements can be delivered to the appropriate location, which can improve the accuracy, efficacy, safety and flexibility of treatment.

[0020] Preferably, the other end of the O2 air intake pipe is connected to an O2 terminal, and the other end of the NO air intake pipe is connected to an NO terminal, and both the O2 terminal and the NO terminal are arranged on the housing.

[0021] By adopting the above technical solution, by connecting an O2 terminal to the other end of the O2 inlet pipe and an NO terminal to the other end of the NO inlet pipe, and arranging them on the outer casing, it is possible to provide the advantages of convenient connection, flexible combination, safe protection, easy observation and maintenance, and neat appearance; these advantages help to improve the convenience of operation and the reliability of the mixed oxygen nitric oxide therapeutic device.

[0022] Preferably, a first gas filter is provided between the second flow rate controller and the NO inlet pipe, and a second gas filter is provided between the first flow rate controller and the O2 inlet pipe.

[0023] By adopting the above technical solution, by providing a first gas filter between the second flow rate controller and the NO inlet pipe, and a second gas filter between the first flow rate controller and the O2 inlet pipe, pollutants in the air can be effectively filtered, the treatment effect can be improved, and safety can be provided. These benefits help protect the safety of equipment and patients and provide high-quality treatment effects.

[0024] Preferably, a sampling pump is provided between the third interface of the three-way pipe and the gas content sensor.

[0025] By adopting the above technical solution and providing a sampling pump between the third interface of the tee and the gas content sensor, it is possible to improve sampling accuracy, shorten sampling time, expand sampling range, protect the gas content sensor, and adapt to a variety of gases. These benefits help improve the accuracy, stability and reliability of gas measurement.

[0026] Preferably, the gas content sensor includes an O2 content sensor, a NO content sensor and a NO2 content sensor, and the O2 content sensor, the NO content sensor and the NO2 content sensor are arranged in parallel.

[0027] By adopting the above technical solutions, gas content sensors can accurately measure and monitor the content of gases such as O2, NO, and NO2. This helps understand the concentrations of gas components and provides important data for medical process control. It is worth noting that by monitoring O2 content, low or high oxygen concentrations in the air can be promptly detected, thereby avoiding safety risks caused by insufficient or excessive O2. Parallel configuration of O2, NO, and NO2 content sensors enables comprehensive monitoring, mutual calibration, fault tolerance, cross-validation, and expanded applications. These benefits help improve the accuracy, stability, and reliability of gas measurement systems.

[0028] Preferably, NO treatment is used to increase the 6MWT distance by 70±17.19 meters, reduce the pulmonary artery pressure by 20.71±10.42 mmHg, and reduce the percentage of pulmonary artery pressure by 29.51±0.09%, and the NO flow rate is used to enhance the therapeutic effect.

[0029] By adopting the above technical solution, the therapeutic effect of NO can be effectively improved by increasing the 6MWT distance, reducing the pulmonary artery pressure and reducing the pulmonary artery pressure percentage.

[0030] In summary, this application has the following beneficial effects:

[0031] 1. The flow control system of the mixed oxygen nitric oxide therapy device can improve the stability and reliability of treatment by accurately controlling the gas flow rate, evenly mixing the gas, detecting the gas content and providing safety protection functions, ensuring that the patient obtains the accurate gas concentration, while ensuring the patient's safety and improving the operability of the system. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] FIG1 is a flow chart of an oxygen mixing flow control system according to the present embodiment;

[0033] FIG2 is a schematic diagram of the overall structure of the mixed oxygen type nitric oxide therapeutic apparatus in this embodiment;

[0034] FIG3 is an internal exploded view of the housing in this embodiment;

[0035] FIG4 is an internal cross-sectional view of the mixed oxygen type nitric oxide therapeutic apparatus in this embodiment;

[0036] FIG5 is a schematic diagram of the overall structure of the connection between the connecting sleeve and the fixed sleeve in this embodiment;

[0037] FIG6 is a schematic diagram of the explosion structure between the connecting sleeve and the fixed sleeve in this embodiment;

[0038] Explanation of the accompanying drawings: 1. Housing; 2. T-tube; 3. O2 inlet pipe; 4. NOx inlet pipe; 5. First flow rate controller; 6. Second flow rate controller; 7. Gas content sensor; 8. O2 terminal; 801. Connecting sleeve; 802. Fixing sleeve; 803. Conical thread protrusion; 804. Conical thread recess; 805. Notch; 806. Sealing ring; 9. NOx terminal; 10. First gas filter; 11. Second gas filter; 12. Sampling pump; 13. Output pipe. DETAILED DESCRIPTION

[0039] The present application is described in further detail below in conjunction with the accompanying drawings. It is necessary to point out that the following specific implementation methods are only used to further illustrate the present application and cannot be understood as limiting the scope of protection of the present application. Technicians in this field can make some non-essential improvements and adjustments to the present application based on the above application content.

[0040] The present invention discloses a mixed oxygen type nitric oxide therapeutic device and flow control system, as shown in FIG1 , wherein the mixed oxygen type flow control system includes a NO intake module, an O2 intake module, a flow rate control module, an O2 and NO mixing module, a gas content sensor module and an output component;

[0041] The output end of the NO intake module and the output end of the O2 intake module are both connected to the input end of the flow rate control module, the output end of the flow rate control module is connected to the input end of the O2 and NO mixing module, the output end of the O2 and NO mixing module is connected to the input end of the gas content sensor module, the output end of the gas content sensor module is connected to the input end of the output component, the gas content sensor module is used to detect the content of each component of O2, NO and NO2, when the content of each component of O2, NO and NO2 is less than or equal to the threshold value, the switch of the output component is started; the intake amount of NO and O2 is controlled by the flow rate control module, the flow rate control module can accurately control the intake amount of NO and O2, ensure that the flow rate of the gas is constant during treatment, and can improve the stability and reliability of treatment. , ensure that the patient obtains accurate gas concentration, and uses the mixing module to evenly mix NO and O2 to ensure the uniformity of gas during treatment; it can improve the treatment effect, make the gas concentration inhaled by the patient more uniform, and reduce the impact of concentration differences on the patient; through the gas content sensing module, the content of NO, NO2 and O2 is detected for real-time monitoring of the gas concentration during treatment; it can effectively ensure that the gas concentration inhaled by the patient is within a safe range, avoiding the adverse effects of excessively high or low concentrations on the patient. When the content of each component of O2, NO and NO2 is less than or equal to the threshold, the switch of the output component will be started to ensure that the gas concentration is within a safe range, which can effectively provide additional safety protection to prevent patients from being harmed by abnormal gas concentrations;

[0042] In summary, the flow control system of the mixed oxygen nitric oxide therapy device can improve the stability and reliability of treatment by accurately controlling the gas flow rate, evenly mixing the gas, detecting the gas content and providing safety protection functions, ensuring that the patient obtains the accurate gas concentration, while ensuring the patient's safety and improving the operability of the system.

[0043] As shown in Figure 1, the gas content sensing module includes an O2 content sensing component, a NO content sensing component, and a NO2 content sensing component. The gas content sensing module can monitor gas content in real time. Through the measurement of the sensing component, the concentration of O2, NO, and NO2 can be timely understood to ensure that the gas concentration during treatment meets the requirements and provide accurate content data to ensure the accuracy and effectiveness of treatment. Based on the content data provided by the sensing component, the operator can adjust the treatment parameters in a timely manner, such as adjusting the gas flow rate or concentration, to meet the specific needs of the patient. The sensing component can also provide data recording and analysis functions to record the changing trend of gas content. This data can be used for diagnosis and research, helping doctors evaluate the treatment effect and make more reasonable treatment decisions. In summary, the O2 content sensing component, NO content sensing component, and NO2 content sensing component of the gas content sensing module can monitor gas content in real time, provide accurate measurement results and safety protection, help adjust treatment parameters, and record and analyze data, thereby improving the safety and effectiveness of treatment.

[0044] As shown in FIG1 , the mixed oxygen flow control system further includes a filter module, which is arranged between the output end of the NO intake module and the input end of the flow rate control module; the filter module can filter out impurities in the air entering the system, such as dust, particulate matter, bacteria, etc.; it can ensure the purity of the gas and prevent impurities from having adverse effects on the treatment instrument and the patient; the filter module can prevent impurities from entering the flow rate control module, reduce damage and malfunction to the flow rate control module, and extend the service life of the flow rate control module, and the filter module can filter out harmful substances in the air, reduce the risk of harmful gases inhaled by the patient, and protect the patient's respiratory health; and the filter module can ensure the purity and quality of the gas, ensure that the gas used in the treatment process meets the requirements, can effectively improve the treatment effect, and reduce adverse reactions caused by impurities or harmful substances; and the filter module is usually easy to replace and can be replaced or cleaned regularly to maintain its filtering effect; it helps to maintain the normal operation of the equipment and the continuity of treatment;

[0045] In summary, placing the filter module between the output end of the NO intake module and the input end of the flow rate control module can filter impurities, protect patients, improve treatment effects, and provide convenient replacement and maintenance.

[0046] As shown in Figure 1, the output end of the gas content sensor module is also connected to an alarm component. When the content of any of the components O2, NO, and NO2 exceeds the threshold, the alarm component is activated. When the gas content exceeds the threshold, the alarm component can emit a sound or light signal to alert the operator or patient to the abnormal gas content. This allows timely detection of problems and avoidance of potential dangers. Since gas content exceeding the threshold may cause harm to patients or equipment, activating the alarm component can immediately stop the gas supply to ensure the safety of patients and equipment. When the gas content exceeds the threshold, the triggering of the alarm component can also remind the operator to perform maintenance work. For example, it may be necessary to replace the sensor component or check the gas supply system to restore normal gas content. In addition, activating the alarm component can record the abnormal gas content event and associate it with other data. This data can be used for analysis and research to help improve treatment equipment and processes and enhance the quality and safety of treatment.

[0047] In summary, by connecting the output end of the gas content sensor module to the alarm component and setting a threshold, the alarm component is activated when the gas content exceeds the threshold. This can provide timely warnings, safety protection, prevention of excessive concentration, maintenance reminders, and data recording and analysis functions; these functions help ensure the safety and effectiveness of treatment.

[0048] As shown in Figures 2 and 3, based on the above-mentioned mixed oxygen flow control system, the mixed oxygen nitric oxide therapeutic device includes a shell 1 and a three-way pipe 2 arranged in the shell 1, the three-way pipe 2 is provided with a first interface, a second interface and a third interface, the shell 1 is provided with an O2 inlet pipe 3 and a NO inlet pipe 4, one end of the O2 inlet pipe 3 is connected to a first flow rate controller 5, one end of the NO inlet pipe 4 is connected to a second flow rate controller 6, the output end of the first flow rate controller 5 is connected to the first interface of the three-way pipe 2, the output end of the second flow rate controller 6 is connected to the second interface of the three-way pipe 2, the third interface of the three-way pipe 2 is connected to a gas content sensor 7, and the output end of the gas content sensor 7 is connected to an output pipe 13; O2 and NO are provided to the inside of the first flow rate controller 5 and the second flow rate controller 6 respectively through the O2 inlet pipe 3 and the NO inlet pipe 4 to ensure that the components of the mixed gas meet the set requirements; this helps to provide precise gas control and The therapeutic effect can be achieved by precisely controlling the flow rate and ratio of O2 and NO under the action of the first flow rate controller 5 and the second flow rate controller 6, and making O2 and NO uniformly mixed in the three-way pipe 2. The O2 and NO in the mixed gas in the three-way pipe 2 can be used in a targeted manner in the treatment process; the appropriate O2 concentration can provide sufficient oxygen to promote the patient's oxygenation; and the appropriate amount of NO can be used to treat respiratory system-related diseases; the application of the mixed gas can enhance the therapeutic effect, and when the content of each component of O2, NO and NO2 is less than or equal to the threshold value through the inside of the gas content sensor 7, it indicates that the mixed gas meets the safety requirements; this helps to ensure the safety of patients and equipment, and the O2, NO and NO2 that meet the set requirements are output to the appropriate position through the output pipe 13, and the mixed gas can be delivered to a specific treatment device or patient breathing interface as needed; this provides a flexible application method to adapt to different treatment needs;

[0049] In summary, through precise mixed gas control and safety monitoring, O2, NO and NO2 that meet the set requirements can be delivered to the appropriate location, which can improve the accuracy, efficacy, safety and flexibility of treatment.

[0050] As shown in Figures 3 and 4, the other end of the O2 intake pipe 3 is connected to the O2 terminal 8, and the other end of the NO intake pipe 4 is connected to the NO terminal 9. The O2 terminal 8 and the NO terminal 9 are both arranged on the housing 1; by arranging the O2 terminal 8 and the NO terminal 9 on the housing 1, the O2 intake pipe 3 and the NO intake pipe 4 can be easily connected; this can simplify the connection process and improve the convenience of operation; and by arranging the terminal on the housing 1, different intake pipes can be easily replaced or combined; for example, according to actual needs, different types of O2 intake pipes 3 or NO intake pipes 4 can be replaced, or multiple intake pipes can be used in combination; this provides more flexible configuration options; and arranging the terminal on the housing 1 can effectively isolate the connection between the intake pipe and the circuit to avoid safety problems such as current leakage or short circuit; this helps to protect the The safety of the mixed oxygen nitric oxide therapeutic device and the operator; and by arranging the terminal blocks on the housing 1, the connection status can be easily observed and checked; if necessary, the connection can be checked at any time to see if it is firm, or maintenance and replacement can be carried out; by arranging the O2 terminal blocks 8 and the NO terminal blocks 9 on the housing 1, the entire connection system can look more tidy and beautiful; this helps to improve the appearance quality of the mixed oxygen nitric oxide therapeutic device and make it more professional; in summary, by connecting the O2 terminal blocks 8 to the other end of the O2 inlet pipe 3 and the NO terminal blocks 9 to the other end of the NO inlet pipe 4, and arranging them on the housing 1, the advantages of convenient connection, flexible combination, safe protection, easy observation and maintenance, and neat and beautiful appearance can be provided; these advantages help to improve the convenience of operation and the reliability of the mixed oxygen nitric oxide therapeutic device.

[0051] As shown in FIG4 , a first gas filter 10 is provided between the second flow rate controller 6 and the NO inlet pipe 4, and a second gas filter 11 is provided between the first flow rate controller 5 and the O2 inlet pipe 3; the first gas filter 10 and the second gas filter 11 can effectively filter pollutants in the air; can effectively prevent harmful substances such as particulate matter, bacteria, viruses, etc. from entering the mixed gas circulation system, thereby protecting the safety of the equipment and patients, and effectively reducing impurities entering the mixed gas system; this can reduce damage and wear to the equipment, thereby extending the service life of the equipment; and by using the first gas filter 10 and the second gas filter 11, the purity of the mixed gas can be ensured; pure Clean oxygen and nitric oxide can provide higher quality treatment effects and reduce unnecessary interference factors; the first gas filter 10 and the second gas filter 11 can prevent harmful substances in the air from entering the mixed gas system, reducing the risk of patients being exposed to harmful substances; this helps to ensure the safety of treatment; in summary, by providing a first gas filter 10 between the second flow rate controller 6 and the NO inlet pipe 4, and providing a second gas filter 11 between the first flow rate controller 5 and the O2 inlet pipe 3, pollutants in the air can be effectively filtered, the treatment effect can be improved, and safety protection can be provided; these benefits help to protect the safety of equipment and patients and provide high-quality treatment effects.

[0052] As shown in Figure 4, a sampling pump 12 is provided between the third interface of the three-way pipe 2 and the gas content sensor 7; the sampling pump 12 can actively extract gas samples to ensure the reliability and representativeness of the samples; it can help avoid sampling deviations caused by passive sampling and improve the accuracy and precision of gas content measurement, and the sampling pump 12 can provide additional gas flow force to make the gas sample flow through the gas content sensor 7 more quickly, which helps to shorten the sampling time and improve the efficiency of real-time monitoring; and the introduction of the sampling pump 12 can increase the amount of gas samples collected and expand the sampling range; this is very important for applications that need to measure low-concentration gases, and can improve the sensitivity and reliability of detection; in addition, the sampling pump 12 can connect the gas content sensor 7 to the gas content sensor 7 The body source is isolated to avoid direct contact of the gas with the gas content sensor 7, reducing the risk of contamination and damage; this helps to extend the service life of the gas content sensor 7 and improve the stability and reliability of the equipment. Moreover, the sampling pump 12 can adjust the flow rate and pressure of the gas as needed to adapt to gas samples of different types and concentrations; this enables the gas content sensor 7 to adapt to various application scenarios and provide more flexible and reliable gas measurement; in summary, by providing a sampling pump 12 between the third interface of the tee pipe 2 and the gas content sensor 7, the sampling accuracy can be improved, the sampling time can be shortened, the sampling range can be expanded, the gas content sensor 7 can be protected, and it can adapt to a variety of gases; these benefits help to improve the accuracy, stability and reliability of gas measurement.

[0053] As shown in Figure 4, the gas content sensor 7 includes an O2 content sensor, a NO content sensor, and a NO2 content sensor; the gas content sensor 7 can accurately measure and monitor the content of gases such as O2, NO, and NO2; this helps to understand the concentration of gas components and provides important data for medical process control, etc.; it is worth noting that by monitoring the O2 content, it is possible to timely detect the situation of too low or too high oxygen concentration in the air to avoid safety risks caused by O2 deficiency or O2 excess; the O2 content sensor, the NO content sensor, and the NO2 content sensor are arranged in parallel; through the parallel arrangement, the content of O 2、 NO and NO2 can be monitored simultaneously; this helps to comprehensively understand the concentration changes of gas components and provides more comprehensive data and information; through the parallel arrangement, mutual calibration can be carried out between different O2 content sensors, NO content sensors, and NO2 content sensors; the measurement results of different O2 content sensors, NO content sensors, and NO2 content sensors can be compared and corrected with each other to improve the accuracy and reliability of measurement; if any of the O2 content sensors, NO content sensors, and NO2 content sensors fails, the other sensors can still work normally, thus ensuring the continuity and stability of the monitoring system; this parallel arrangement can improve the fault tolerance ability of the system; through the parallel arrangement, cross-verification can be carried out on the measurement results of different O2 content sensors, NO content sensors, and NO2 content sensors; if the results of different O2 content sensors, NO content sensors, and NO2 content sensors are consistent, the confidence in the measurement results can be increased; if the results are inconsistent, further inspection and correction can be carried out, and the parallel arrangement between the O2 content sensor, the NO content sensor, and the NO2 content sensor can be conveniently extended to more gas content sensors 7 to monitor more types of gas components; this is very useful for the requirements of different environments and application scenarios and improves the flexibility and adaptability of the sensor system; in summary, arranging the O^2 content sensor, the NO content sensor, and the NO2 content sensor in parallel can achieve various benefits such as comprehensive monitoring, mutual calibration, fault tolerance, cross-verification, and extended application; these benefits help to improve the accuracy, stability, and reliability of the gas measurement system; it is worth noting that NO treatment is used to increase the 6MWT distance by 77.19 meters, reduce the pulmonary artery pressure by 25.42 mmHg, and reduce the percentage of pulmonary artery pressure by 29.6%, and the NO flow rate is used to enhance the treatment effect, by increasing the 6MWT distance, reducing the pulmonary artery pressure, and reducing the percentage of pulmonary artery pressure, so as to effectively improve the treatment effect of NO.

[0054] As shown in Figures 5 and 6, it is worth noting that the O2 terminal 8 and the NO terminal 9 have the same structure, and the O2 terminal 8 includes a connecting sleeve 801 and a fixed sleeve 802. The fixed sleeve 802 is arranged on the outer shell and is connected to the O2 air intake pipe 3. A tapered thread protrusion 803 is provided inside the fixed sleeve 802, and a tapered thread recess 804 matching the tapered thread protrusion 803 is provided on one side of the outer surface of the connecting sleeve 801. The design of the tapered thread protrusion 803 and the tapered thread recess 804 makes the joint between the connecting sleeve 801 and the fixed sleeve 802 have better connection stability; the tapered thread structure can provide a larger contact area and a tighter connection, thereby reducing the risk of loosening and air leakage; the tapered thread structure design between the connecting sleeve 801 and the fixed sleeve 802 makes disassembly and installation more convenient; by rotating the connecting sleeve 801, it can be easily inserted or pulled out of the fixed sleeve. 802, to achieve quick disassembly and installation; this is very helpful for the maintenance and replacement of the equipment; and a number of notches 805 are provided on the tapered threaded recessed portion 804 of the connecting sleeve 801, and a channel for the output pipe of the O2 tank to pass through is provided inside the connecting sleeve 801, and the output pipe of the O2 tank is aligned with the O2 intake pipe 3, and a sealing ring 806 is provided between the connecting sleeve 801 and the output pipe of the O2 tank. The sealing ring 806 is provided between the connecting sleeve 801 and the output pipe of the O2 tank to ensure that the gas at the connection will not leak; the sealing ring 806 can provide reliable airtightness to prevent oxygen from leaking or entering areas where it should not exist, thereby ensuring the safety and performance of the system; in summary, the structural design between the connecting sleeve 801 and the fixed sleeve 802 can provide good connection stability, convenient disassembly and installation, and excellent sealing performance, thereby facilitating the normal operation and maintenance of the oxygen intake system and ensuring the safety and performance of the system.

[0055] Working Principle: During use, the user can connect the O2 terminal 8 and the NO terminal 9 to the O2 tank and the NO tank respectively. The O2 and NO in the O2 tank and the NO tank enter the interior of the O2 inlet pipe 3 and the NO inlet pipe 4 respectively. Among them, O2 passes through the second gas filter 11 and the first flow rate controller 5 in sequence and enters the three-way pipe 2, while NO passes through the first gas filter 10 and the second flow rate controller 6 in sequence and enters the three-way pipe 2. They are uniformly mixed inside the three-way pipe 2, and the mixed O2, NO and NO2 are output through the output pipe 13 to play a therapeutic role for the patient.

[0056] It is worth noting that when the content of each component of O2, NO and NO2 is less than or equal to the threshold value, it can be output through the output tube 13. When the content of any component among O2, NO and NO2 is greater than the threshold value, the buzzer set on the shell is used to serve as a warning alarm to monitor and remind of the abnormal content of O2, NO and NO2 components.

[0057] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.

Claims

1. A mixed oxygen flow control system, characterized in that: It includes a NO intake module, an O2 intake module, a constant pressure module, a filtering module, a flow rate control module, an O2 and NO mixing module, a gas content sensor module and an output component; The output end of the NO air intake module and the output end of the O2 air intake module are both connected to the constant pressure module and the filtering module, and then connected to the input end of the flow rate control module. The output end of the flow rate control module is connected to the input end of the O2 and NO mixing module. The output end of the O2 and NO mixing module is connected to the input end of the gas content sensor module. The output end of the gas content sensor module is connected to the input end of the output component. The gas content sensor module is used to detect the content of each component of O2, NO and NO2. When the content of each component of O2, NO and NO2 is less than or equal to a threshold value, the switch of the output component is started.

2. The mixed oxygen flow control system according to claim 1, characterized in that: The gas content sensor module includes an O2 content sensor component, a NO content sensor component and a NO2 content sensor component.

3. The mixed oxygen flow control system according to claim 1, characterized in that: It also includes a filter module, which is arranged between the output end of the NO intake module and the input end of the flow rate control module.

4. The mixed oxygen flow control system according to claim 1, characterized in that: The output end of the gas content sensor module is also connected to an alarm component. When the content of any one of the components of O2, NO and NO2 is greater than or less than a threshold value, the switch of the alarm component is activated.

5. A mixed oxygen nitric oxide therapeutic apparatus, the mixed oxygen nitric oxide therapeutic apparatus is based on the mixed oxygen flow control system according to any one of claims 1 to 4, characterized in that: The invention comprises a housing (1) and a three-way pipe (2) arranged in the housing (1), wherein the three-way pipe (2) is provided with a first interface, a second interface and a third interface, and the housing (1) is provided with an O2 intake pipe (3) and a NO intake pipe (4), one end of the O2 intake pipe (3) is connected to a first flow rate controller (5), one end of the NO intake pipe (4) is connected to a second flow rate controller (6), the output end of the first flow rate controller (5) is connected to the first interface of the three-way pipe (2), the output end of the second flow rate controller (6) is connected to the second interface of the three-way pipe (2), the third interface of the three-way pipe (2) is connected to a gas content sensor (7), and the output end of the gas content sensor (7) is connected to an output pipe (13).

6. The mixed oxygen type nitric oxide therapeutic device according to claim 5, characterized in that: The other end of the O2 air intake pipe (3) is connected to an O2 terminal (8), and the other end of the NO air intake pipe (4) is connected to an NO terminal (9). Both the O2 terminal (8) and the NO terminal (9) are arranged on the housing (1).

7. The mixed oxygen type nitric oxide therapeutic device according to claim 6, characterized in that: A first gas filter (10) is provided between the second flow rate controller (6) and the NO intake pipe (4), and a second gas filter (11) is provided between the first flow rate controller (5) and the O2 intake pipe (3).

8. The mixed oxygen type nitric oxide therapeutic device according to claim 5, characterized in that: A sampling pump (12) is provided between the third interface of the three-way pipe (2) and the gas content sensor (7).

9. The mixed oxygen type nitric oxide therapeutic device according to claim 8, characterized in that: The gas content sensor (7) comprises an O2 content sensor, a NO content sensor and a NO2 content sensor, and the O2 content sensor, the NO content sensor and the NO2 content sensor are arranged in parallel.

10. The mixed oxygen nitric oxide therapeutic apparatus according to claim 5, characterized in that: NO treatment was used to increase the 6MWT distance by 70±17.19 m, reduce pulmonary artery pressure by 20.71±10.42 mmHg, and reduce the percentage of pulmonary artery pressure by 29.51±0.09%. NO flow rate was used to enhance the therapeutic effect.

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