Flash-release throat soothing composition, preparation method therefor, and use thereof

Abstract

A flash-release throat soothing composition, a preparation method therefor, and a use thereof. The flash-release throat soothing composition is prepared from the following raw materials: traditional Chinese medicine components, polyhydric sugar alcohol, and starch, wherein the mass ratio of the starch to the polyhydric sugar alcohol is 1:(0.5-1.6). The flash-release throat soothing composition is prepared by compounding polyhydric sugar alcohol and starch according to a specific mass ratio, pre-mixing, granulating, then mixing with other materials, performing wet granulation, and further adopting a wet granulation mode comprising first performing low-temperature drying treatment and then performing high-temperature drying and sterilization. The flash-release throat soothing composition does not contain any binder and disintegrating agent.

Description

A flash-release throat moistening composition and its preparation method and application

[0001] Priority claim: The present invention claims priority to Chinese patent application No. 2023116624748, filed on December 6, 2023, the entire contents of which are incorporated herein by reference. Technical Field

[0002] The invention belongs to the technical field of food preparations, and particularly relates to a flash-release throat-soothing composition, a preparation method and an application thereof. Background Art

[0003] In the era of comprehensive wellness, driven by shifting health awareness and behavior, the category and market demand for functional foods with specific nutritional and health benefits are steadily expanding. Solid beverages with inherent carrying properties, combined with functional nutritional ingredients such as traditional Chinese medicines with both medicinal and edible properties, are a promising option for embracing future health trends. Throat lozenges offer cooling, antipyretic, anti-inflammatory, analgesic, soothing, and refreshing benefits. They stimulate the salivary glands, promoting saliva production and providing some relief from throat discomfort.

[0004] Patent of invention CN107007655A discloses a compound Coral Grass lozenge, comprising 4-6 parts of Coral Grass extract, 2-4 parts of menthol extract, 1-3 parts of peppermint oil, 50-60 parts of sucrose, 10-20 parts of glucose syrup, 3-7 parts of shell powder-based quick-dissolving agent, 9-11 parts of filler, 1-3 parts of lubricant, and 2-4 parts of coating agent. The patent's Coral Grass lozenge has a high dissolution efficiency in the oral cavity and can quickly relieve the discomfort caused by sore throat. However, the patent's preparation process is complicated and uses many types of auxiliary materials, which increases the cost. The active ingredient dissolution time is long, and it does not achieve the effect of instant dissolution, and it is impossible to quickly relieve throat discomfort.

[0005] Invention patent CN102100326B discloses compound Tibetan green fruit throat lozenges and their preparation method. The compound Tibetan green fruit throat lozenges contain 4-12% Tibetan green fruit water extract, 1-4% green tea water extract, 7-12% polyethylene glycol 6000, 0.5-1.5% gum arabic, 70-85% sorbitol, erythritol, or isomalt, and 0.3-3% sweetener. The addition of a large number of excipients reduces the content of active ingredients compared to equivalent specifications, increasing costs accordingly.

[0006] Invention patent CN110313597A discloses an instant, no-rinse throat-soothing granule and its preparation method. The instant, no-rinse throat-soothing granule contains 20-50 parts of monk fruit, 20-50 parts of mint, 20-50 parts of platycodon grandiflorum, 20-50 parts of licorice, 10-30 parts of bitter almond, 10-100 parts of sugar alcohol, 20-40 parts of instant fruit powder, 30-100 parts of starch, 3-10 parts of disintegrant, 0.05-0.3 parts of sweetener, 0.1-0.8 parts of citric acid, and 0.05-0.4 parts of menthol. The preparation process in this patent is demanding, complex, and costly.

[0007] Currently, throat-soothing solid beverage products on the market take more than ten seconds to dissolve in artificial saliva or water, which cannot quickly relieve discomfort symptoms. In addition, the existing instant dissolution process is complex and costly.

[0008] Therefore, there is an urgent need to develop a flash-release throat-soothing composition that is low in cost, simple in process, quickly dissolves, requires fewer types of excipients, and has a good taste.

[0009] Summary of the Invention

[0010] In order to solve the technical problems of high cost, complicated preparation process and poor instant dissolution effect, the present invention aims to provide a flash-release throat moistening composition and a preparation method thereof.

[0011] In order to achieve the above object, the present invention adopts the following technical solutions:

[0012] The invention provides a flash-release throat-soothing composition comprising the following raw materials: traditional Chinese medicine components, polysaccharide alcohol and starch.

[0013] Furthermore, the Chinese medicinal ingredients include liquorice, ginseng, bitter almonds, and platycodon.

[0014] Furthermore, the mass ratio of the starch to the polyol is 1:0.5-1.6.

[0015] Furthermore, the mass ratio of the starch to the polyol is 1:0.8-1.6.

[0016] Furthermore, the mass ratio of the starch to the polyol is 1:1 or 1.5.

[0017] Furthermore, the polyol is at least one of erythritol, xylitol and sorbitol.

[0018] Furthermore, the starch is potato starch and / or corn starch.

[0019] Furthermore, the flash-release throat-loosening composition comprises the following raw materials, calculated by weight: 2.25-5.25 parts of Chinese herbal medicine powder or Chinese herbal medicine extract, 40-55 parts of polysaccharide alcohol, and 40-60 parts of starch.

[0020] Furthermore, the Chinese medicine ingredient is Chinese medicine powder or Chinese medicine extract.

[0021] Furthermore, the mass ratio of licorice, ginseng, bitter almond and platycodon in the traditional Chinese medicine ingredients is 1-4: 0.01-0.5: 0.01-0.5: 0.01-0.25.

[0022] Furthermore, the flash-release throat soothing composition further comprises the following raw materials: sweetener, menthol, and citric acid.

[0023] Furthermore, the flash-release throat soothing composition comprises the following raw materials, in parts by weight: 2.25-5.25 parts of traditional Chinese medicine powder or extract, 40-55 parts of polysaccharide alcohol, 40-60 parts of starch, 3.5-6.5 parts of sweetener, 1.5-2.5 parts of menthol, and 1-1.25 parts of citric acid.

[0024] Furthermore, the sweetener is at least one of mogroside, sucralose, steviol glycoside, sucrose and mannitol.

[0025] The present invention also provides a method for preparing the flash-release throat-loosening composition, comprising the following steps:

[0026] S1. Weighing polyols and starch according to the formula, mixing, granulating, granulating, and drying to obtain polyol-starch mixed pregranulation;

[0027] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and anhydrous citric acid according to the formula amount, mix them with the sugar alcohol-starch mixed pre-granulation described in step S1, granulate, shape the granules, and dry them to obtain a flash-release throat-soothing composition.

[0028] Furthermore, the granulation in steps S1 and S2 is wet granulation.

[0029] Furthermore, in the wet granulation in step S1, the stirring speed is 100-300 rpm, the cutter speed is 1000-2500 rpm, the water addition amount is 5wt%-7.5wt%, the water inlet rate is 200-400 rpm, and the temperature is 20-25°C.

[0030] Furthermore, in the wet granulation in step S2, the stirring speed is 100-300 rpm, the cutter speed is 1000-2500 rpm, the water addition amount is 5wt%-12.5wt%, the water inlet rate is 200-400 rpm, and the temperature is 20-25°C.

[0031] Furthermore, the drying in step S1 is: drying at 40-50° C. for 0.5-1.5 h.

[0032] Furthermore, the drying in step S2 is as follows: drying at 40-50° C. for 0.5-2.5 h, and then drying at 80-90° C. for 0.5-1 h.

[0033] The present invention also provides use of the flash-release throat moistening composition in preparing food, health care products or medicines for relieving throat discomfort.

[0034] The present invention also provides a flash-release product for relieving throat discomfort, comprising the flash-release throat moistening composition.

[0035] Furthermore, the dosage form of the product is granules or microcapsules, pills, powders or tablets.

[0036] Polysaccharide alcohols are prone to recrystallization. If directly mixed with other materials for wet granulation and then dried, the finished product will have a distinctly granular feel and be difficult to disintegrate in artificial saliva, failing to achieve the desired instant dissolution effect. Starch is a water-soluble material. By encapsulating the polysaccharide alcohol with starch to form a dispersed structure, the resulting granules exhibit instant dissolution. Water solubility can be maintained during the subsequent granulation process. Because it is a water-soluble material, its release rate in artificial saliva is less than two seconds, resulting in a flash-release effect.

[0037] Starch is easily soluble in water and has hydroscopic properties. During the wet granulation process, it absorbs water and combines with sugar alcohol to form an inclusion compound. During the drying process, the moisture content is reduced, making the small particle group structure tighter and the particles more dispersed, preventing the recrystallization of sugar alcohol and ensuring the dissolution rate.

[0038] It avoids the recrystallization of polyols, which affects the dissolution of subsequent products and causes granular taste. At the same time, low-temperature drying can prevent the gelatinization properties of starch from changing and affecting the yield rate.

[0039] The beneficial effects of the present invention are:

[0040] The instant-release throat-loosening composition of the present invention comprises a pre-granulated mixture of a polyol and starch in a specific mass ratio, which is then wet-granulated with other materials. The wet-granulation process is then followed by low-temperature drying and high-temperature drying for sterilization to obtain the instant-release throat-loosening composition. The sugar alcohols avoid direct contact with other materials, ensuring instant dissolution while maintaining a good mouthfeel.

[0041] The flash-release throat moistening composition of the present invention helps to relieve pain in the throat, quickly relieves throat discomfort, and the cooling feeling reaches the throat instantly and lasts for a long time.

[0042] The invention has undergone rigorous formula and process research, does not contain any adhesives and disintegrants, has good taste, low cost, good instant dissolution effect, good throat moistening effect, simple preparation process and good formability while ensuring the content of effective ingredients. DETAILED DESCRIPTION

[0043] The following describes the embodiments of the present invention through specific examples. Those skilled in the art will readily understand the other advantages and benefits of the present invention from the disclosure herein. The present invention may also be implemented or applied through various other specific embodiments, and the details in this specification may be modified or altered based on different viewpoints and applications without departing from the spirit of the present invention.

[0044] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.

[0045] When numerical ranges are given in the examples, it should be understood that, unless otherwise specified herein, both endpoints of each numerical range and any value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention belongs.

[0046] The present invention does not limit the sources of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are all common commercial products in the field of this technology. Chinese herbal medicine powders are all directly crushed and sieved from Chinese herbal medicines. The standards of Chinese herbal medicine extracts and Chinese herbal medicine powders are tested in accordance with the first and fourth parts of the 2020 edition of the Chinese Pharmacopoeia, and the results meet the requirements. The main component of licorice extract is liquiritin (C 21 H 22 O9) and glycyrrhizic acid (C 42 H 62 O 16 ), licorice extract, calculated on a dry basis, contains liquiritin (C 21 H 22 O9) 0.50%, glycyrrhizic acid (C 42 H 62 O 16 )7.0%. The main component of ginseng extract is total ginsenosides. Ginseng extract, calculated on a dry basis, contains ginsenoside Re(C 48 H 82 O 18 ) should be 65-70%. The main component of bitter almond extract is amygdalin (C 20 H 27 NO 11 ), bitter almond extract was purchased from Xi'an Beijinuo Biotechnology Co., Ltd., with a specification of 20:1. The main component of Platycodon grandiflorum extract is platycodin, and Platycodon grandiflorum extract was purchased from Shaanxi Taike Biotechnology Co., Ltd., with a specification of 20:1.

[0047] Example

[0048] Example 1

[0049] A flash-release throat-soothing composition comprises, by weight, 45 parts of erythritol, 45 parts of potato starch, 2.2 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.05 parts of platycodon grandiflorum extract, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

[0050] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0051] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator with stirring. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 5.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 40°C for 0.5 h to produce the sugar alcohol-starch mixed pregranules.

[0052] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix them with the sugar alcohol-starch pre-granulated mixture described in step S1, and then place them in a wet granulator for stirring. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 10.5 wt %, water inflow rate 200 rpm, and temperature 25°C. After stirring, the mixture is added to a granulator for granulation. After granulation, the granules are dried at 45°C for 1 hour, then heated to 85°C and dried for 0.5 hour to obtain a flash-release throat-soothing composition.

[0053] Example 2

[0054] A flash-release throat-soothing composition comprises, by weight, 55 parts of erythritol, 50 parts of potato starch, 2.35 parts of liquorice extract, 0.2 parts of ginseng powder, 0.2 parts of bitter almond powder, 0.25 parts of platycodon powder, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

[0055] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0056] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator with stirring. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 5.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 50°C for 1.5 hours to produce the sugar alcohol-starch mixed pregranules.

[0057] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula, mix with the sugar alcohol-starch pre-granulated mixture described in step S1, and stir in a wet granulator. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 10.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, the mixture is added to a granulator for granulation. After granulation, the granules are dried at 50°C for 0.5 h, then heated to 90°C and dried for 0.5 h.

[0058] Example 3

[0059] A flash-release throat moistening composition comprises, by weight, 40 parts of xylitol, 60 parts of potato starch, 4 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.25 parts of platycodon powder, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

[0060] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0061] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The wet granulator parameters are as follows: stirring speed 250 rpm, cutter speed 1500 rpm, water addition amount 7.5 wt %, water inflow rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 50°C for 1.5 hours to produce the polyol-starch mixed pregranules.

[0062] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula, mix with the sugar alcohol-starch pre-granulated mixture described in step S1, and stir in a wet granulator. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 10.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, the mixture is added to a granulator for granulation. After granulation, the granules are dried at 50°C for 0.5 h, then heated to 90°C and dried for 0.5 h.

[0063] Example 4

[0064] A flash-release throat-soothing composition comprises, by weight, 45 parts of erythritol, 50 parts of corn starch, 3.72 parts of liquorice powder, 0.01 part of ginseng extract, 0.01 part of bitter almond extract, 0.01 part of platycodon grandiflorum extract, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

[0065] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0066] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The wet granulator parameters are as follows: stirring speed 250 rpm, cutter speed 1500 rpm, water addition amount 7.5 wt %, water inflow rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 50°C for 1.5 hours to produce the polyol-starch mixed pregranules.

[0067] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula, mix with the sugar alcohol-starch pre-granulated mixture described in step S1, and stir in a wet granulator. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 10.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, the mixture is added to a granulator for granulation. After granulation, the granules are dried at 50°C for 0.5 h, then heated to 90°C and dried for 0.5 h.

[0068] Example 5

[0069] A flash-release throat moistening composition comprises, by weight, 50 parts of sorbitol, 40 parts of corn starch, 3.2 parts of liquorice extract, 0.4 parts of ginseng powder, 0.3 parts of bitter almond powder, 0.1 parts of platycodon extract, 6.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

[0070] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0071] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The wet granulator parameters are as follows: stirring speed 250 rpm, cutter speed 1500 rpm, water addition amount 6.5 wt %, water inflow rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 45°C for 1 hour to produce the sugar alcohol-starch mixed pregranules.

[0072] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula, mix with the sugar alcohol-starch pre-granulated mixture described in step S1, and stir in a wet granulator. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 10.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, the mixture is added to a granulator for granulation. After granulation, the granules are dried at 45°C for 1 hour, then heated to 85°C and dried for 0.5 hour.

[0073] Example 6

[0074] A flash-release throat-soothing composition comprises, by weight, 45 parts of erythritol, 45 parts of potato starch, 2.2 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.05 parts of platycodon grandiflorum extract, 5.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid.

[0075] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0076] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator for stirring. The wet granulator parameters are as follows: stirring speed 250 rpm, cutter speed 1500 rpm, water addition amount 6.5 wt %, water inflow rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 45°C for 1 hour to produce the sugar alcohol-starch mixed pregranules.

[0077] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula, mix with the sugar alcohol-starch pre-granulated mixture described in step S1, and stir in a wet granulator. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 10.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, the mixture is added to a granulator for granulation. After granulation, the granules are dried at 45°C for 1 hour, then heated to 85°C and dried for 0.5 hour.

[0078] Example 7

[0079] A flash-release throat-soothing composition comprises, by weight, 45 parts of erythritol, 45 parts of potato starch, 2.2 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.05 parts of platycodon grandiflorum extract, 3.5 parts of sweetener, 1.5 parts of menthol, and 1 part of citric acid.

[0080] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0081] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator with stirring. The wet granulator parameters are as follows: stirring speed 100 rpm, cutter speed 1500 rpm, water addition amount 5.5 wt %, water inflow rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 45°C for 1 hour to produce the polyol-starch mixed pregranules.

[0082] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix with the sugar alcohol-starch pre-granulated mixture described in step S1, and stir in a wet granulator. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 12.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, the material is added to a granulator for granulation. After granulation, the granules are dried at 45°C for 1 hour, then heated to 85°C and dried for 0.5 hour.

[0083] Example 8

[0084] A flash-release throat-soothing composition comprises, by weight, 45 parts of erythritol, 45 parts of potato starch, 1 part of liquorice powder, 0.5 part of ginseng extract, 0.5 part of bitter almond powder, 0.25 part of platycodon grandiflorum extract, 4.5 parts of sweetener, 1.5 parts of menthol, and 1 part of citric acid.

[0085] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0086] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator with stirring. The wet granulator parameters are as follows: stirring speed 100 rpm, cutter speed 1500 rpm, water addition amount 5.5 wt %, water inflow rate 300 rpm, temperature 20°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 45°C for 1 hour to produce the polyol-starch mixed pregranules.

[0087] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix with the sugar alcohol-starch pre-granulated mixture described in step S1, and stir in a wet granulator. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 12.5 wt %, water inflow rate 200 rpm, temperature 25°C. After stirring, the material is added to a granulator for granulation. After granulation, the granules are dried at 45°C for 1 hour, then heated to 85°C and dried for 0.5 hour.

[0088] Example 9

[0089] A flash-release throat-soothing composition comprises, by weight, 53 parts of erythritol, 35 parts of potato starch, 3 parts of liquorice powder, 0.1 part of ginseng extract, 0.1 part of bitter almond, 0.1 part of platycodon grandiflorum extract, 5.5 parts of sweetener, 2.5 parts of menthol, and 1 part of citric acid.

[0090] The preparation method of the flash-release throat-soothing composition comprises the following steps:

[0091] S1. Weigh the polyol and starch according to the formula, mix them, and add them to a wet granulator with stirring. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 7.5 wt%, water inflow rate 200 rpm, temperature 25°C. After stirring, add the materials to a granulator for granulation. After granulation, dry them at 40°C for 0.5 h to produce the sugar alcohol-starch mixed pregranules.

[0092] S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, and citric acid according to the formula amount, mix them with the sugar alcohol-starch pre-granulated mixture described in step S1, and stir them in a wet granulator. The wet granulator parameters are as follows: stirring speed 200 rpm, cutter speed 2000 rpm, water addition amount 12.5 wt %, water inflow rate 200 rpm, and temperature 25°C. After stirring, the mixture is added to a granulator for granulation. After granulation, the granules are dried at 45°C for 1.5 hours, then heated to 85°C and dried for 0.5 hours to obtain a flash-release throat-soothing composition.

[0093] Example 10

[0094] A flash-release throat-soothing composition comprises, by weight, 51 parts of erythritol, 34 parts of potato starch, 5 parts of liquorice powder, 0.5 parts of ginseng extract, 0.5 parts of bitter almond powder, 0.5 parts of platycodon grandiflorum extract, 5.5 parts of sweetener, 2.5 parts of menthol, and 1 part of citric acid.

[0095] The preparation method is the same as Example 9.

[0096] Example 11

[0097] A flash-release throat-soothing composition comprises, by weight, 54 parts of erythritol, 36 parts of potato starch, 1 part of liquorice powder, 0.01 part of ginseng extract, 0.1 part of bitter almond powder, 0.1 part of platycodon grandiflorum extract, 5.5 parts of sweetener, 2.5 parts of menthol, and 1 part of citric acid.

[0098] The preparation method is the same as Example 9.

[0099] Comparative Example

[0100] Comparative Example 1

[0101] The difference between this comparative example and Example 1 is that potato starch is not used, and the preparation method does not perform step S1 of pre-granulation.

[0102] Comparative Example 2

[0103] The difference between this comparative example and Example 1 is that erythritol is not used, and the preparation method does not perform step S1 of pre-granulation.

[0104] Comparative Example 3

[0105] The difference between this comparative example and Example 1 is that the weight ratio of potato starch to erythritol is different; specifically, the weight ratio of potato starch to erythritol is 1:2, wherein the weight parts of potato starch are 30 parts and the weight parts of erythritol are 60 parts.

[0106] Comparative Example 4

[0107] This comparative example differs from Example 1 in that the weight ratio of potato starch to erythritol is different; specifically, the weight ratio of potato starch to erythritol is 1:0.4, with 60 parts by weight of potato starch and 24 parts by weight of erythritol. During the wet granulation process, the amount of water added was increased to 13%, and the drying time in step S1 was extended to 3 hours.

[0108] Comparative Example 5

[0109] The difference between this comparative example and Example 1 is that the preparation method is different; specifically, step S1 is not performed, and all the raw materials and auxiliary materials are mixed and then directly wet granulated. After the wet granulation, the materials are granulated, and after the granulation, they are dried at 45°C for 1 hour and then dried at 85°C for 0.5 hour.

[0110] Comparative Example 6

[0111] The difference between this comparative example and Example 1 is that the drying process is different. Specifically, the drying process in step S2 is drying at 60° C. for 2 hours.

[0112] Comparative Example 7

[0113] The difference between this comparative example and Example 1 is that the wet granulation process is different. Specifically, the amount of water added in step S2 of the wet granulation process is 20 wt %.

[0114] Comparative Example 8

[0115] The difference between this comparative example and Example 1 is that the dosage of the Chinese medicinal ingredients is different; specifically, the amount of the Chinese medicinal extract is 10 parts by weight.

[0116] Comparative Example 9

[0117] The difference between this comparative example and Example 1 is that the amount of menthol used is different; specifically, the amount of menthol used is 3 parts by weight.

[0118] Comparative Example 10

[0119] The difference between this comparative example and Example 1 is that the dosage of menthol and the dosage of the Chinese herbal medicine extract are different; specifically, the dosage of menthol is 0.5 parts by weight and the dosage of the Chinese herbal medicine extract is 3 parts by weight.

[0120] Comparative Example 11

[0121] Jin Xiaocao Throat Soothing Treasures, purchased from Shanghai Jianshun Biotechnology Co., Ltd., product standard code Q / HSHLY 0001S, product patent number ZL201711013148.9

[0122] Comparative Example 12

[0123] The ingredients in Example 1 of CN110313597A, namely, “30 parts of instant fruit powder, sugar alcohol (70 parts of sorbitol, 10 parts of mannitol), 40 parts of potato starch, disintegrant (4 parts of sodium carboxymethyl starch, 1 part of polyvidone), sweetener (0.15 parts of steviol glycosides, 0.05 parts of sucralose), 0.6 parts of citric acid, and 0.3 parts of menthol”, were used instead of “45 parts of erythritol, 45 parts of potato starch, 5.5 parts of sweetener, 2.5 parts of menthol, and 1.25 parts of citric acid” in Example 1 of the present application.

[0124] Effect performance test

[0125] 1. Evaluation of the physical and chemical properties of the flash-release throat moistening composition

[0126] 1. Experimental Methods

[0127] 1.1 Dissolution time evaluation

[0128] Examples 1-11 and Comparative Examples 1-5 and Comparative Examples 8-12 were evaluated using dissolution time (in artificial saliva and in water at room temperature) as an indicator.

[0129] 1.2 Formability evaluation

[0130] Examples 1-11 and Comparative Examples 1-10 were evaluated based on the formulation formability.

[0131] 1.3 Oral Evaluation

[0132] For Examples 1-11, Comparative Examples 1-5 and Comparative Examples 8-12, 20 sensory evaluation panelists were selected to evaluate the products based on four indicators: solubility (in artificial saliva), solubility (in water at room temperature), mouthfeel, and throat moistening effect.

[0133] 2. Experimental Results

[0134] 2.1 Dissolution time evaluation

[0135] The dissolution time results for Examples 1-11, Comparative Examples 1-5, and Comparative Examples 8-12 are shown in Table 1. As can be seen from the table, the Examples exhibited excellent instant dissolution, with dissolution times in artificial saliva ranging from 1.56 to 1.85 seconds, while Example 1 required only 1.56 seconds to dissolve in artificial saliva. The Examples also exhibited excellent dissolution in room-temperature water, rapidly dispersing upon contact with water and rapidly dissolving after stirring, requiring less than 2 seconds. However, Comparative Examples 1-5 and Comparative Examples 11-12 took longer to dissolve in artificial saliva, with Comparative Example 1 exhibiting the longest dissolution time of 23.18 seconds. Comparative Examples 1, 3, 4, and 11 exhibited poor dissolution in room-temperature water, with Comparative Examples 1, 3, 4, and 11 still leaving residue at the bottom of the beaker after stirring. Comparative Example 1 exhibited the worst dissolution effect. The specific mass ratio of erythritol to starch changed, resulting in poor instant dissolution.

[0136] Table 1

[0137] 2.2 Formability evaluation

[0138] The formulation formability of Examples 1-11 and Comparative Examples 1-10 was evaluated, and the results are shown in Table 2. As can be seen from the results in Table 2, the molding effects of Examples 1-11, Comparative Examples 5, and Comparative Examples 8-10 are good. However, the molding effect of Comparative Examples 1-4 is not good, and Comparative Examples 6-7 cannot be molded. Among them, when the mass ratio of erythritol in Comparative Example 3 is too high, the mixture cannot ensure a uniformly dispersed state, resulting in an increase in the contact area between erythritol molecules during the wet drying process and an increase in the crystallization rate. The mass ratio of starch in Comparative Example 4 is too high, and the amount of water added needs to be increased during wet granulation, resulting in the drying time having to be extended in the subsequent steps, and a gelatinized and unmolded state is likely to occur in step S2. Starch gelatinization occurs during the drying process in Comparative Example 6, and it cannot be molded. In the whole granulation process, Comparative Example 7 experiences agglomeration, and starch gelatinization occurs during the subsequent drying process, and it cannot be molded.

[0139] Table 2

[0140] 2.3 Comprehensive Evaluation

[0141] The evaluation results of solubility (in artificial saliva), solubility (in room temperature water), taste, and throat moistening effect are shown in Table 3. As can be seen from the table, the Example has a good dissolution effect, a good taste, no bitterness, can quickly relieve throat discomfort after use, and is more effective for smokers. Comparative Example 11 has a slightly bitter taste, a noticeable astringency after taking it, poor patient compliance, poor dissolution effect, takes 7.25 seconds to dissolve in artificial saliva, and there is still powder residue after stirring in room temperature water. The throat moistening effect is slow to relieve throat discomfort.

[0142] Table 3

[0143] 3. Conclusion

[0144] The present invention's flash-release throat soothing composition, formulated with a polyol and starch, offers enhanced instant solubility. The starch and polyol are pre-mixed and granulated, then wet-granulated with other materials and then dried at low temperature. This combination of ingredients yields a low-cost, instant-dissolving, pleasant-tasting, and long-lasting throat relief composition.

[0145] The above further describes the present invention in conjunction with specific embodiments. However, these embodiments are merely exemplary and do not constitute any limitation on the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solutions of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, and such modifications and replacements shall fall within the scope of protection of the present invention.

Claims

1. A flash-release throat moistening composition, characterized in that: The raw materials include: Chinese herbal medicine ingredients, polyols and starch; The Chinese medicinal ingredients include liquorice, ginseng, bitter almonds, and platycodon; The mass ratio of the starch to the polyol is 1:0.5-1.

6.

2. The flash-release throat moistening composition according to claim 1, characterized in that: The polyol is at least one of erythritol, xylitol and sorbitol; and the starch is at least one of potato starch and corn starch.

3. The flash-release throat moistening composition according to claim 1, characterized in that: The Chinese medicine ingredients are Chinese medicine powder or Chinese medicine extracts.

4. The flash-release throat moistening composition according to claim 1, characterized in that: The mass ratio of liquorice, ginseng, bitter almond and platycodon in the traditional Chinese medicine ingredients is 1-4: 0.01-0.5: 0.01-0.5: 0.01-0.

25.

5. The flash-release throat moistening composition according to claim 1, characterized in that: The raw materials are as follows, calculated by weight: 2.25-5.25 parts of traditional Chinese medicine ingredients, 40-55 parts of polysaccharide alcohols, and 40-60 parts of starch.

6. The flash-release throat moistening composition according to claim 1, characterized in that: The following ingredients are also included: sweetener, menthol, citric acid.

7. The flash-release throat moistening composition according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 3.5-6.5 parts of sweetener, 1.5-2.5 parts of menthol and 1-1.25 parts of citric acid.

8. The flash-release throat moistening composition according to claim 1, characterized in that: The sweetener is at least one of mogroside, sucralose, stevioside, sucrose and mannitol.

9. The method for preparing the flash-release throat moistening composition according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1. Weigh polyols and starch according to the formula, mix, granulate, granulate, and dry to obtain polyol-starch mixed pregranules; S2. Weigh the Chinese medicinal ingredients, sweetener, menthol, anhydrous citric acid according to the formula amount, mix them with the sugar alcohol-starch mixed pre-granulation in step S1, granulate, granulate, and dry to obtain a flash-release throat moistening composition.

10. The preparation method according to claim 9, characterized in that: The granulation in steps S1 and S2 is wet granulation.

11. The preparation method according to claim 10, characterized in that: In the wet granulation of step S1, the stirring speed is 100-300 rpm, the cutting speed is 1000-2500 rpm, the water addition amount is 5wt%-7.5wt%, the water inlet rate is 200-400rpm, and the temperature is 20-25°C; In step S2, the wet granulation is performed at a stirring speed of 100-300 rpm, a cutting speed of 1000-2500 rpm, a water addition amount of 5 wt%-12.5 wt%, a water inlet rate of 200-400 rpm, and a temperature of 20-25° C.; The drying in step S1 is: drying at 40-50°C for 0.5-1.5h; The drying in step S2 is as follows: drying at 40-50°C for 0.5-2.5h, and then drying at 80-90°C for 0.5-1h.

12. Use of the flash-release throat moistening composition according to any one of claims 1 to 8 or the flash-release throat moistening composition prepared by the preparation method according to any one of claims 9 to 11 in preparing foods, health products and medicines for relieving throat discomfort.

13. A flash-release product for relieving throat discomfort, characterized in that: A flash-release throat moistening composition comprising the flash-release throat moistening composition described in any one of claims 1 to 8 or the flash-release throat moistening composition prepared by the preparation method described in any one of claims 9 to 11.

14. The product according to claim 13, characterized in that The dosage form of the product is granules, microcapsules, pills, powders or tablets.

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