Nonaqueous composition for oral cavity

Abstract

The present invention relates to a nonaqueous composition for the oral cavity which, when applied to the oral cavity, brings about a comfortable sense of foaming and a satisfactory use feeling with reduced oiliness and which, after storage, can be effectively prevented from generating a carbon dioxide gas.　This nonaqueous composition for the oral cavity comprises the following components (A) to (E): (A) a nonaqueous solvent having a relative permittivity at 25°C of less than 10 and a melting point of 0°C or lower, (B) an acid that is solid at 25°C, (C) a carbonic acid salt, (D) an oily gellant, and (E) a sugar alcohol that is solid at 25°C.

Description

Non-aqueous oral composition

[0001] The present invention relates to non-aqueous oral compositions.

[0002] Non-aqueous oral compositions containing an organic acid and a carbonate as carbon dioxide gas generators can generate carbon dioxide gas when applied to the oral cavity, resulting in a unique effervescent sensation, and various non-aqueous oral compositions have been developed to date.

[0003] For example, Patent Document 1 discloses an oral composition containing a base for a non-aqueous oral composition, baking soda, and an acidic component that is solid at room temperature, and attempts to increase foaming properties while mitigating bitterness, astringency, etc. Patent Document 2 discloses a toothpaste containing an organic acid coated with a coating agent, sodium bicarbonate coated with a coating material, and polyacrylic acid, which aims to suppress the generation of carbon dioxide gas when stored for a long period of time.

[0004] (Patent Document 1) JP 2002-302429 A (Patent Document 2) JP 2022-81908 A

[0005] The present invention provides a non-aqueous oral composition containing the following components (A) to (E): (A) a non-aqueous solvent having a relative dielectric constant of less than 10 at 25°C and a melting point of 0°C or lower, (B) an acid that is solid at 25°C, (C) a carbonate, (D) an oil-based gelling agent, and (E) a sugar alcohol that is solid at 25°C.

[0006] Regardless of the technology described in any of the above patent documents, there is still room for improvement in terms of ensuring a good feel in use in which a pleasant foaming sensation is provided in the oral cavity when applied while suppressing oily sensation, and further in terms of sufficiently preventing the generation of carbon dioxide gas even after storage.

[0007] Therefore, the present invention relates to a non-aqueous oral composition that, when applied to the oral cavity, provides a pleasant foaming sensation and a good usability with reduced oiliness, and can effectively prevent the generation of carbon dioxide gas even after storage.

[0008] After extensive investigation, the present inventors have found that by containing a non-aqueous solvent having a specific dielectric constant, an acid that is solid at 25°C, a carbonate, an oily gelling agent, and a sugar alcohol that is solid at 25°C, it is possible to obtain a non-aqueous oral composition that not only maintains good manufacturing stability while providing a good foaming sensation and feel upon use, but also has excellent storage stability, thereby effectively preventing the generation of carbon dioxide gas even after storage.

[0009] When the non-aqueous oral composition of the present invention is applied to the oral cavity, carbon dioxide gas forms bubbles with a distinctive, pleasant effervescent sensation that pop pleasantly in the oral cavity, while suppressing any unpleasant oily sensation, providing a refreshing, invigorating sensation even after use. Furthermore, the non-aqueous oral composition of the present invention exhibits excellent storage stability while maintaining good shape retention and manufacturing stability, and effectively prevents carbon dioxide gas generation even after storage, thereby preventing unnecessary swelling of the container filled with the composition during storage.

[0010] In the evaluation of storage stability, photographs of the containers after storage, which were taken from the side while standing upright, are shown in Fig. 1(a) for Example 1, Fig. 1(b) for Comparative Example 1, and Fig. 1(c) for Comparative Example 2. Detailed Description of the Invention

[0011] The present invention will be described in detail below. In the present invention, the term "non-aqueous oral composition" refers to a composition that does not contain water as an ingredient and that is substantially free of water except when unavoidably mixed. "Substantially free of water" means that the moisture content of the oral composition is preferably less than 2% by mass, more preferably less than 1% by mass. Furthermore, the term "good effervescence" refers to the fact that, when applied to the oral cavity, the acid and carbonate that are solid at 25°C and contained as carbon dioxide gas generators in the non-aqueous oral composition of the present invention react with the moisture in saliva to generate carbon dioxide gas, which then disperses in the oral cavity as bubbles with a distinctively pleasant effervescence, popping pleasantly and providing a refreshing feel. Furthermore, the term "good usability" refers to a feeling that suppresses unpleasant oiliness and does not impair flavor when applied to the oral cavity. Therefore, the "refreshing feeling" provided by the non-aqueous oral composition of the present invention is a general term for the excellent feeling in the oral cavity, which includes not only the good "foaming feeling" and "feel of use" when applied to the oral cavity, but also the "refreshing feeling" that is felt even after application in addition to these feelings.

[0012] The nonaqueous oral composition of the present invention contains, as component (A), a nonaqueous solvent having a dielectric constant of less than 10 at 25°C and a melting point of 0°C or lower. The nonaqueous oral composition of the present invention contains, as carbon dioxide gas generators, component (B), a solid acid at 25°C (described below), and component (C), a carbonate salt. The presence of component (A) effectively prevents unnecessary carbon dioxide gas generation during production, storage, or before use, significantly contributing to ensuring excellent storage stability while maintaining good production stability. Furthermore, when the nonaqueous oral composition of the present invention is applied to the oral cavity, contact with saliva or the like causes a reaction between component (B) and component (C), generating carbon dioxide gas bubbles that provide a unique, pleasant effervescence in the oral cavity. These bubbles then diffuse throughout the oral cavity, pleasantly popping and providing a refreshing sensation. In the present invention, a "nonaqueous solvent" refers to a solvent other than water that is substantially free of water. Furthermore, the "melting point" refers to a value at 1 atmosphere.

[0013] The dielectric constant of component (A) at 25°C is less than 10, preferably 5 or less, and more preferably 3 or less. Furthermore, component (A) has a melting point of 0°C or less, preferably -10°C or less. Specific examples of component (A) include one or more oils selected from hydrocarbon oils, volatile silicone oils, and ester oils.

[0014] The hydrocarbon oil may be one or more selected from liquid paraffin, squalane, vaseline, and turpentine oil.

[0015] Examples of the volatile silicone oil include one or more selected from octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane, octamethyltrisiloxane, tetradecamethylhexasiloxane, and low-viscosity methylpolysiloxane.

[0016] The ester oil may be one or more selected from jojoba oil, argan oil, olive oil, coconut oil, and the like.

[0017] Among these components (A), from the viewpoint of effectively preventing the generation of unnecessary carbon dioxide gas during production, storage, or before use and ensuring excellent storage stability, hydrocarbon oils are preferred, one or two selected from liquid paraffin and squalane are more preferred, and liquid paraffin is even more preferred. Liquid paraffin is a colorless, odorless, liquid mixture of alkanes having 20 or more carbon atoms, and commercially available known products can be used. There are no particular limitations on the liquid paraffin, but in the present invention, those that comply with the standards prescribed in the Standards for Quasi-drug Raw Materials and the like can be preferably used. More specifically, the liquid paraffin used as component (A) is a liquid paraffin having a density of 0.800 to 0.900 g / cm at 15°C. 3 is preferred, and 0.820 to 0.890 g / cm 3 More preferably, 0.845 to 0.885 g / cm 3 More preferably, it is 0.850 to 0.880 g / cm 3Furthermore, the liquid paraffin used as component (A) is preferably one having a viscosity of 1 to 120 mm at 37.8°C. 2 / s is preferred, and 10 to 100 mm 2 / s is more preferable, and 37 to 95 mm 2 / s is more preferable, and 40 to 90 mm 2 / s is even more preferable, and 74 to 88 mm 2 The viscosity of the liquid paraffin is a value measured using a glass capillary viscometer in accordance with the description of JIS K-2283.

[0018] From the viewpoints of effectively enhancing storage stability and providing a good usability with suppressed unpleasant oily feeling when applied to the oral cavity, the content of component (A) in the non-aqueous oral composition of the present invention is preferably 15% by mass or more, more preferably 20% by mass or more, even more preferably 25% by mass or more, still more preferably 30% by mass or more, preferably 50% by mass or less, more preferably 45% by mass or less, even more preferably 41% by mass or less, and still more preferably 38% by mass or less. The content of component (A) in the non-aqueous oral composition of the present invention is preferably 15 to 50% by mass, more preferably 20 to 45% by mass, even more preferably 25 to 41% by mass, and even more preferably 30 to 38% by mass.

[0019] The nonaqueous oral composition of the present invention contains, as component (B), an acid that is solid at 25° C. When the nonaqueous oral composition of the present invention is applied to the oral cavity, the presence of saliva etc. causes a reaction between component (B) and a carbonate salt of component (C), which will be described later, to generate carbon dioxide gas bubbles that provide a unique, pleasant effervescence that brings about a refreshing feeling.

[0020] Examples of component (B) include organic acids or amino acids having 4 to 6 carbon atoms and having 1 to 3 carboxyl groups in the molecule. More specifically, examples include one or more selected from malic acid, citric acid, succinic acid, fumaric acid, tartaric acid, adipic acid, aspartic acid, glutamic acid, and pyroglutamic acid. Among these, from the viewpoint of ensuring a good foaming sensation, one or more selected from malic acid, citric acid, tartaric acid, and succinic acid are preferred, one or two selected from malic acid and tartaric acid are more preferred, and malic acid is even more preferred. The content of malic acid in component (B) is preferably 20% by mass or more, preferably 40% by mass or more, more preferably 60% by mass or more, even more preferably 80% by mass, and even more preferably 100% by mass.

[0021] Furthermore, component (B) contained in the non-aqueous oral composition of the present invention may or may not have a coating layer made of a coating material. However, from the viewpoint of generating pleasantly popping carbon dioxide bubbles in the oral cavity and exhibiting a good effervescent sensation, it is preferable that component (B) does not have a coating layer. "Component (B) not having a coating layer" means that part or all of the surface of component (B) is not coated with a coating material, i.e., no coating layer is formed on part or all of the surface of component (B). The coating material is used as a material to coat part or all of the surface of component (B) in advance in order to suppress unwanted reactions in the non-aqueous oral composition during production, storage, or before use, thereby preventing the generation of carbon dioxide gas. Any coating material can be used as long as it can coat part or all of the surface of component (B).

[0022] From the viewpoint of generating pleasantly popping carbon dioxide bubbles in the oral cavity and ensuring a good foaming sensation, the content of component (B) in the non-aqueous oral composition of the present invention is preferably 6% by mass or more, more preferably 8% by mass or more, even more preferably 10% by mass or more, and preferably 25% by mass or less, more preferably 22% by mass or less, and even more preferably 18% by mass or less. The content of component (B) in the non-aqueous oral composition of the present invention is preferably 6 to 25% by mass, more preferably 8 to 22% by mass, and even more preferably 10 to 18% by mass.

[0023] The non-aqueous oral composition of the present invention contains a carbonate as component (C). Specific examples of component (C) include one or more selected from sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate, and magnesium carbonate. Of these, from the viewpoint of enhancing storage stability, one or two selected from sodium bicarbonate and sodium carbonate are preferred, and it is more preferred to contain both sodium bicarbonate and sodium carbonate. Furthermore, from the viewpoint of enhancing the effervescent sensation, sodium carbonate is preferred.

[0024] When sodium bicarbonate and sodium carbonate are contained as component (C), from the viewpoint of generating pleasantly popping carbon dioxide gas bubbles and ensuring a good foaming feeling, the content of sodium carbonate in 100% by mass of component (C) is preferably 10% by mass or more, more preferably 15% by mass or more, and preferably 35% by mass or less, more preferably 30% by mass or less.

[0025] Furthermore, component (C) contained in the non-aqueous oral composition of the present invention has good manufacturing stability and excellent storage stability, and therefore, like component (B), it may or may not have a coating layer. However, from the viewpoint of generating carbon dioxide gas bubbles that pop pleasantly in the oral cavity and creating a good foaming sensation, it is preferable that component (C) also does not have a coating layer. The absence of a coating layer in component (C) means that part or all of the surface of component (C) is not coated with a coating material. The coating material is used as a material to coat part or all of the surface of component (C) in advance in order to suppress unwanted reactions in the non-aqueous oral composition during manufacturing, storage, or before use, thereby preventing the generation of carbon dioxide gas.

[0026] From the viewpoint of generating pleasantly popping carbon dioxide gas bubbles in the oral cavity and ensuring a good foaming sensation, the content of component (C) in the non-aqueous oral composition of the present invention is preferably 6% by mass or more, more preferably 8% by mass or more, even more preferably 10% by mass or more, and preferably 35% by mass or less, more preferably 32% by mass or less, and even more preferably 30% by mass or less. The content of component (C) in the non-aqueous oral composition of the present invention is preferably 6 to 35% by mass, more preferably 8 to 32% by mass, and even more preferably 10 to 30% by mass.

[0027] From the viewpoint of generating an appropriate amount of carbon dioxide gas to form bubbles that burst pleasantly in the oral cavity, the mass ratio of the content of component (B) to the content of component (C) ((B) / (C)) is preferably 0.3 or more, more preferably 0.4 or more, even more preferably 0.5 or more, and preferably 1.1 or less, more preferably 1 or less, and even more preferably 0.9 or less. The mass ratio of the content of component (B) to the content of component (C) ((B) / (C)) is preferably 0.3 to 1.1, more preferably 0.4 to 1, and even more preferably 0.5 to 0.9.

[0028] From the viewpoints of promoting the diffusion of carbon dioxide gas bubbles in the oral cavity and ensuring excellent storage stability, the total content of component (B) and component (C) in the non-aqueous oral composition of the present invention is preferably 12% by mass or more, more preferably 15% by mass or more, even more preferably 18% by mass or more, and preferably 55% by mass or less, more preferably 53% by mass or less, and even more preferably 50% by mass or less. The total content of component (B) and component (C) in the non-aqueous oral composition of the present invention is preferably 12 to 55% by mass, more preferably 15 to 53% by mass, and even more preferably 18 to 50% by mass.

[0029] The mass ratio ({(B)+(C)} / (A)) of the total content of components (B) and (C) to the content of component (A) is preferably 0.2 or more, more preferably 0.3 or more, even more preferably 0.5 or more, and preferably 3.5 or less, more preferably 2.5 or less, and even more preferably 2 or less, from the viewpoints of allowing the reaction between components (B) and (C) to proceed upon contact with saliva or the like when applied to the oral cavity, thereby effectively generating highly diffusible carbon dioxide gas bubbles that bring about a good foaming sensation, and providing a good feel in use with a suppressed unpleasant oily sensation when applied to the oral cavity. The mass ratio ({(B)+(C)} / (A)) of the total content of components (B) and (C) to the content of component (A) is preferably 0.2 to 3.5, more preferably 0.3 to 2.5, and even more preferably 0.5 to 2.

[0030] The non-aqueous oral composition of the present invention contains an oily gelling agent as component (D). The oily gelling agent of component (D) is a component that can solidify or gelatinize component (A), contributes to the development of appropriate shape retention, and ensures good production stability.

[0031] Examples of such component (D) include fatty acids, fatty acid esters, and fatty acid condensates, such as dextrin fatty acid esters, 12-hydroxystearic acid, and oligomers obtained by condensing a mixed fatty acid consisting of glycerin, behenic acid, and eicosanedioic acid; petroleum waxes or natural waxes having a melting point (at 1 atmosphere) of 50°C or higher, such as microcrystalline wax, polyethylene wax, paraffin wax, Fischer-Tropsch wax, carnauba wax, candelilla wax, ozokerite, and ceresin wax; resin powders such as polyethylene powder; metal soaps such as zinc stearate, calcium stearate, calcium palmitate, lithium 2-ethylhexanoate, and aluminum 12-hydroxystearate; N-acylamino acid amides such as lauroyl glutamic acid dibutylamide, lauroyl glutamic acid stearylamide, and dicaproyl lysine lauroyl phenylalanine laurylamide; and N-acylamino acid amine salts such as dicaproyl lysine laurylamine salt. N-acylamino acid esters such as dicaproyl lysine lauryl ester; and one or more clay minerals such as bentonite, organically modified bentonite, laponite, etc. Among these component (D), from the viewpoints of effectively promoting the solidification or gelation of component (A) and effectively suppressing unwanted reactions between component (B) and component (C), one or more fatty acids, fatty acid esters, or fatty acid condensates are preferred, and dextrin fatty acid esters are more preferred.

[0032] From the viewpoint of favorably solidifying or gelling component (A) and preventing the generation of carbon dioxide gas, the content of component (D) in the non-aqueous oral composition of the present invention is preferably 0.5% by mass or more, more preferably 0.7% by mass or more, even more preferably 1% by mass or more, preferably 5% by mass or less, more preferably 4% by mass or less, even more preferably 3% by mass or less, still more preferably 2.3% by mass or less, and even more preferably 1.8% by mass or less. The content of component (D) in the non-aqueous oral composition of the present invention is preferably 0.5 to 5% by mass, more preferably 0.7 to 4% by mass, even more preferably 1 to 3% by mass, still more preferably 1 to 2.3% by mass, and even more preferably 1 to 1.8% by mass.

[0033] The mass ratio ((A) / (D)) of the content of component (A) to the content of component (D) is preferably 10 or more, more preferably 12 or more, even more preferably 15 or more, still more preferably 18 or more, still more preferably 20.5 or more, preferably 30 or less, more preferably 27 or less, and even more preferably 25 or less, from the viewpoints of generating pleasantly popping carbon dioxide bubbles in the oral cavity by component (B) and component (C), ensuring a good foaming sensation, and providing a good usability with suppressed unpleasant oily sensation when applied to the oral cavity. The mass ratio ((A) / (D)) of the content of component (A) to the content of component (D) is preferably 10 to 30, more preferably 12 to 27, even more preferably 15 to 25, still more preferably 18 to 25, and even more preferably 20.5 to 25.

[0034] The nonaqueous oral composition of the present invention contains, as component (E), a sugar alcohol that is solid at 25°C. The solubility of component (E) in water at 25°C (the amount dissolved in a 100% by weight saturated aqueous solution at 25°C) is preferably 5% by weight or more, more preferably 8% by weight or more, even more preferably 12% by weight or more, even more preferably 20% by weight or more, and preferably 75% by weight or less, more preferably 65% ​​by weight or less, and even more preferably 55% by weight or less, from the viewpoints of ensuring a good feel when used in the oral cavity with a reduced unpleasant oily feeling and a good foaming sensation, and of enabling rapid dissolution and diffusion by saliva when applied to the oral cavity. The solubility of component (E) in water at 25°C is preferably 5 to 75% by weight, preferably 8 to 65% by weight, more preferably 12 to 55% by weight, and even more preferably 20 to 55% by weight.

[0035] Specific examples of such component (E) include one or more selected from erythritol, mannitol, sorbitol, xylitol, and reduced palatinose (a mixture of α-D-glucopyranosyl-1,6-sorbitol and α-D-glucopyranosyl-1,6-mannitol). Of these, from the viewpoint of ensuring a good feel in use with reduced oiliness, one or more selected from erythritol, xylitol, and mannitol are preferred, one or two selected from erythritol and xylitol are more preferred, and erythritol is even more preferred.

[0036] From the viewpoint of ensuring a good feel when used with a reduced unpleasant oily sensation and a good foaming sensation when applied to the oral cavity, the content of component (E) in the non-aqueous oral composition of the present invention is preferably 2% by mass or more, more preferably 5% by mass or more, even more preferably 8% by mass or more, still more preferably 15% by mass or more, preferably 45% by mass or less, more preferably 40% by mass or less, and even more preferably 35% by mass or less. The content of component (E) in the non-aqueous oral composition of the present invention is preferably 2 to 45% by mass, more preferably 5 to 45% by mass, even more preferably 8 to 40% by mass, and even more preferably 15 to 35% by mass.

[0037] From the viewpoint of ensuring both a good feel in use with suppressed unpleasant oily feeling and a foaming sensation when applied to the oral cavity, the mass ratio of the content of component (A) to the content of component (E) ((A) / (E)) is preferably 0.4 or more, more preferably 0.6 or more, more preferably 0.8 or more, even more preferably 1 or more, preferably 15 or less, more preferably 8 or less, even more preferably 4 or less, and still more preferably 3.5 or less. The mass ratio of the content of component (A) to the content of component (E) ((A) / (E)) is preferably 0.4 to 15, more preferably 0.6 to 8, even more preferably 0.8 to 4, and even more preferably 1 to 3.5.

[0038] From the viewpoint of ensuring both a good feel in use with suppressed unpleasant oily feeling and a foaming sensation when applied to the oral cavity, the mass ratio of the content of component (B) to the content of component (E) ((B) / (E)) is preferably 0.1 or more, more preferably 0.2 or more, even more preferably 0.3 or more, still more preferably 0.5 or more, and preferably 5 or less, more preferably 2 or less, even more preferably 1.5 or less, and still more preferably 1 or less. The mass ratio of the content of component (B) to the content of component (E) ((B) / (E)) is preferably 0.1 to 5, more preferably 0.2 to 2, even more preferably 0.3 to 1.5, and still more preferably 0.5 to 1.

[0039] From the viewpoint of ensuring both a good feel in use with suppressed unpleasant oily feeling and a foaming sensation when applied to the oral cavity, the mass ratio of the content of component (C) to the content of component (E) ((C) / (E)) is preferably 0.1 or more, more preferably 0.2 or more, even more preferably 0.3 or more, still more preferably 0.35 or more, preferably 8 or less, more preferably 3 or less, even more preferably 2.5 or less, and still more preferably 1.5 or less. The mass ratio of the content of component (C) to the content of component (E) ((C) / (E)) is preferably 0.1 to 8, more preferably 0.2 to 3, even more preferably 0.3 to 2.5, and still more preferably 0.35 to 1.5.

[0040] The non-aqueous oral composition of the present invention preferably further contains one or more metal compounds (F) selected from zinc oxide, magnesium oxide, calcium oxide, aluminum oxide, titanium oxide, sodium sulfate, magnesium sulfate, calcium sulfate, calcium chloride, magnesium chloride, zinc chloride, magnesium silicate, and calcium silicate, from the viewpoint of effectively suppressing unwanted reactions between component (B) and component (C) in the non-aqueous oral composition during production, storage, or before use, preventing the generation of carbon dioxide gas, and ensuring good production stability and excellent storage stability. Among these, from the viewpoint of effectively preventing the generation of carbon dioxide gas, one or more metal compounds selected from zinc oxide, magnesium oxide, and magnesium sulfate are preferred, and one or two metal compounds selected from zinc oxide and magnesium oxide are more preferred.

[0041] From the viewpoint of effectively preventing the generation of carbon dioxide gas in the non-aqueous oral composition during storage or before use, the content of component (F) in the non-aqueous oral composition of the present invention is preferably 0.5% by mass or more, more preferably 0.7% by mass or more, even more preferably 0.8% by mass or more, and preferably 7% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less. The content of component (F) in the non-aqueous oral composition of the present invention is preferably 0.5 to 7% by mass, more preferably 0.7 to 5% by mass, and even more preferably 0.8 to 3% by mass.

[0042] From the viewpoint of effectively preventing the generation of carbon dioxide gas in the non-aqueous oral composition during storage or before use, the mass ratio of the content of component (F) to the content of component (A) ((F) / (A)) is preferably 0.005 or more, more preferably 0.008 or more, even more preferably 0.01 or more, and preferably 0.1 or less, more preferably 0.08 or less, and even more preferably 0.05 or less. The mass ratio of the content of component (F) to the content of component (A) ((F) / (A)) is preferably 0.005 to 0.1, more preferably 0.008 to 0.08, and even more preferably 0.01 to 0.05.

[0043] From the viewpoint of effectively preventing the generation of carbon dioxide gas in the non-aqueous oral composition during storage or before use, the mass ratio of the content of component (F) to the content of component (B) ((F) / (B)) is preferably 0.01 or more, more preferably 0.03 or more, even more preferably 0.05 or more, and preferably 0.7 or less, more preferably 0.6 or less, and even more preferably 0.5 or less. The mass ratio of the content of component (F) to the content of component (B) ((F) / (B)) is preferably 0.01 to 0.7, more preferably 0.03 to 0.6, and even more preferably 0.05 to 0.5.

[0044] From the viewpoint of effectively preventing the generation of carbon dioxide gas in the non-aqueous oral composition during storage or before use, the mass ratio of the content of component (F) to the content of component (C) ((F) / (C)) is preferably 0.005 or more, more preferably 0.008 or more, even more preferably 0.01 or more, and preferably 0.3 or less, more preferably 0.2 or less, and even more preferably 0.1 or less. The mass ratio of the content of component (F) to the content of component (C) ((F) / (C)) is preferably 0.005 to 0.3, more preferably 0.008 to 0.2, and even more preferably 0.01 to 0.1.

[0045] From the viewpoint of enhancing polishing properties, the non-aqueous oral composition of the present invention preferably further contains silicic anhydride. Specific examples of silicic anhydride include fumed, porous, non-porous, or spherical silicic anhydride such as abrasive silica and thickening silica, as well as silicic anhydride obtained by subjecting these to hydrophobic treatment.

[0046] From the viewpoints of effectively increasing abrasiveness and effectively preventing the generation of carbon dioxide gas in the non-aqueous oral composition during storage or before use, the content of silicic anhydride in the non-aqueous oral composition of the present invention is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, even more preferably 1% by mass or more, and preferably 6.9% by mass or less, more preferably 6.5% by mass or less, and even more preferably 6% by mass or less. The content of silicic anhydride in the non-aqueous oral composition of the present invention is preferably 0.1 to 6.9% by mass, more preferably 0.5 to 6.5% by mass, and even more preferably 1 to 6% by mass.

[0047] On the other hand, in the non-aqueous oral composition of the present invention, it is preferable to limit the content of silicic anhydride in order to effectively suppress unwanted reactions between components (B) and (C) in the non-aqueous oral composition during production, storage, or before use, prevent the generation of carbon dioxide gas, and ensure good production stability and excellent storage stability. The content of such silicic anhydride in the non-aqueous oral composition of the present invention is preferably less than 10% by mass, more preferably less than 7% by mass, even more preferably less than 5% by mass, even more preferably less than 4% by mass, and even more preferably less than 1% by mass. Alternatively, it is preferable that the non-aqueous oral composition of the present invention is substantially free of silicic anhydride. Note that "substantially free of silicic anhydride" means that the content of silicic anhydride in the oral composition is less than 0.1% by mass.

[0048] The non-aqueous oral composition of the present invention preferably limits the content of non-aqueous solvents having a dielectric constant of 10 or more at 25°C from the viewpoints of effectively suppressing unwanted reactions between components (B) and (C) in the non-aqueous oral composition during production, storage, or before use, preventing the generation of carbon dioxide gas, ensuring good production stability and excellent storage stability, and ensuring a good foaming sensation. Specific examples of non-aqueous solvents having a dielectric constant of 10 or more at 25°C include glycerin, polyethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, and diglycerin. The content of such non-aqueous solvents having a dielectric constant of 10 or more at 25°C is preferably less than 18% by mass, more preferably 10% by mass or less, even more preferably 6% by mass or less, and even more preferably 3% by mass or less. Alternatively, the non-aqueous oral composition of the present invention preferably contains substantially no non-aqueous solvents having a dielectric constant of 10 or more at 25°C. In addition, "substantially free of non-aqueous solvents having a relative dielectric constant of 10 or more at 25°C" means that the content of non-aqueous solvents having a relative dielectric constant of 10 or more at 25°C in the oral composition is less than 1 mass%.

[0049] The non-aqueous oral composition of the present invention may contain ingredients other than the above-mentioned ingredients, such as antibacterial agents, bactericides, medicinal ingredients, fragrances, colorants, etc., within the scope of not impairing the effects of the present invention.

[0050] The non-aqueous oral composition of the present invention is filled into a deformable container, and when an external force or the like is applied to the container, the non-aqueous oral composition as the content is discharged from a discharge port provided in the container. Such a container is not particularly limited in its form, as long as it has a discharge port. Examples of the container form include a tube container having a container body and a cap with a discharge port, a spout container having a pouch container body, and a squeeze-type container having a container body that can be deformed by squeezing. The material of the container is also not particularly limited. For example, in the case of a tube container having a container body with a multilayered body, the multilayered structure may have an innermost layer made of polyethylene such as low-density polyethylene, as well as a metallic layer such as aluminum, or a synthetic resin layer such as polypropylene or polyethylene terephthalate.

[0051] The non-aqueous oral composition of the present invention has excellent storage stability regardless of the container in which it is filled, and therefore can effectively prevent excessive swelling of the container during storage.

[0052] In relation to the above-described embodiment, the present invention further discloses the following non-aqueous oral composition. [1] A non-aqueous oral composition containing the following components (A) to (E): (A) a non-aqueous solvent having a dielectric constant of less than 10 at 25°C and a melting point of 0°C or lower, (B) an acid that is solid at 25°C, (C) a carbonate, (D) an oily gelling agent, and (E) a sugar alcohol that is solid at 25°C. [2] The non-aqueous oral composition of the above [1], wherein the dielectric constant of component (A) at 25°C is preferably 5 or lower, more preferably 3 or lower, and the melting point of component (A) is 0°C or lower, preferably -10°C or lower. [3] The non-aqueous oral composition of the above [1] or [2], wherein component (A) is one or more oils selected from hydrocarbon oils, volatile silicone oils, and ester oils, with hydrocarbon oils being preferred, one or two oils selected from liquid paraffin and squalane being more preferred, and liquid paraffin being even more preferred. [4] The density of liquid paraffin at 15 ° C. is 0.800 to 0.900 g / cm 3 Preferably, it is 0.820 to 0.890 g / cm 3 More preferably, it is 0.845 to 0.885 g / cm 3 More preferably, it is 0.860 to 0.880 g / cm 3 It is even more preferable that the viscosity at 37.8°C is 1 to 120 mm 2 / s, and 10 to 100 mm 2 / s is more preferable, and 37 to 95 mm 2 / s, more preferably 40 to 90 mm 2 / s, and more preferably 74 to 88 mm 2 [5] The non-aqueous oral composition of any one of [1] to [4] above, wherein the content of component (A) is preferably 15% by mass or more, more preferably 20% by mass or more, even more preferably 25% by mass or more, still more preferably 30% by mass or more, and preferably 50% by mass or less, more preferably 45% by mass or less, even more preferably 41% by mass or less, and still more preferably 38% by mass or less.

[0053] [6] The non-aqueous oral composition of any one of [1] to [5] above, wherein component (B) is preferably an organic acid or amino acid having 4 to 6 carbon atoms and having 1 to 3 carboxy groups in the molecule, more preferably one or more selected from malic acid, citric acid, succinic acid, fumaric acid, tartaric acid, adipic acid, aspartic acid, glutamic acid, and pyroglutamic acid, even more preferably one or more selected from malic acid, citric acid, tartaric acid, and succinic acid, still more preferably one or two selected from malic acid and tartaric acid, and even more preferably malic acid. [7] The non-aqueous oral composition of any one of [1] to [6] above, wherein the content of component (B) is preferably 6% by mass or more, more preferably 8% by mass or more, even more preferably 10% by mass or more, and preferably 25% by mass or less, more preferably 22% by mass or less, and even more preferably 18% by mass or less.

[0054] [8] The non-aqueous oral composition of any one of [1] to [7] above, wherein component (C) is preferably one or more selected from sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate, and magnesium carbonate, more preferably one or two selected from sodium bicarbonate and sodium carbonate, and even more preferably both sodium bicarbonate and sodium carbonate. [9] The non-aqueous oral composition of [8] above, wherein the content of sodium carbonate in 100% by mass of component (C) is preferably 10% by mass or more, more preferably 15% by mass or more, and preferably 35% by mass or less, and more preferably 30% by mass or less.

[10] The non-aqueous oral composition of any one of [1] to [9] above, wherein the content of component (C) is preferably 6% by mass or more, more preferably 8% by mass or more, even more preferably 10% by mass or more, and preferably 35% by mass or less, more preferably 32% by mass or less, and even more preferably 30% by mass or less.

[11] The non-aqueous oral composition of any one of the above [1] to

[10] , wherein the mass ratio of the content of component (B) to the content of component (C) ((B) / (C)) is preferably 0.3 or more, more preferably 0.4 or more, even more preferably 0.5 or more, preferably 1.1 or less, more preferably 1 or less, and even more preferably 0.9 or less.

[12] The non-aqueous oral composition of any one of the above [1] to

[11] , wherein the mass ratio of the total content of components (B) and (C) to the content of component (A) ({(B)+(C)} / (A)) is preferably 0.2 or more, more preferably 0.3 or more, even more preferably 0.5 or more, preferably 3.5 or less, more preferably 2.5 or less, and even more preferably 2 or less.

[0055]

[13] The non-aqueous oral composition of any one of [1] to

[12] above, wherein component (D) is preferably one or more selected from fatty acids, fatty acid esters, and fatty acid condensates, and more preferably a dextrin fatty acid ester.

[14] The non-aqueous oral composition of any one of [1] to

[13] above, wherein the content of component (D) is preferably 0.5% by mass or more, more preferably 0.7% by mass or more, even more preferably 1% by mass or more, preferably 5% by mass or less, more preferably 4% by mass or less, even more preferably 3% by mass or less, still more preferably 2.3% by mass or less, and even more preferably 1.8% by mass or less.

[15] The non-aqueous oral composition of any one of [1] to

[14] above, wherein the mass ratio ((A) / (D)) of the content of component (A) to the content of component (D) is preferably 10 or more, more preferably 12 or more, even more preferably 15 or more, still more preferably 18 or more, still more preferably 20.5 or more, preferably 30 or less, more preferably 27 or less, and even more preferably 25 or less.

[0056]

[16] The non-aqueous oral composition of any one of [1] to

[15] above, wherein the solubility of component (E) in water at 25°C (amount dissolved in 100% by mass of saturated aqueous solution at 25°C) is preferably 5% by mass or more, more preferably 8% by mass or more, even more preferably 12% by mass or more, still more preferably 20% by mass or more, and preferably 75% by mass or less, more preferably 65% ​​by mass or less, and even more preferably 55% by mass or less.

[17] The non-aqueous oral composition of any one of [1] to

[16] above, wherein component (E) is preferably one or more selected from erythritol, mannitol, sorbitol, xylitol, and reduced palatinose (a mixture of α-D-glucopyranosyl-1,6-sorbitol and α-D-glucopyranosyl-1,6-mannitol), more preferably one or more selected from erythritol, xylitol, and mannitol, even more preferably one or two selected from erythritol and xylitol, and still more preferably erythritol.

[18] The non-aqueous oral composition of any one of [1] to

[17] above, wherein the content of component (E) is preferably 2% by mass or more, more preferably 5% by mass or more, even more preferably 8% by mass or more, still more preferably 15% by mass or more, and preferably 45% by mass or less, more preferably 40% by mass or less, and even more preferably 35% by mass or less.

[19] The non-aqueous oral composition of any one of [1] to

[18] above, wherein the mass ratio ((A) / (E)) of the content of component (A) to the content of component (E) is preferably 0.4 or more, more preferably 0.6 or more, more preferably 0.8 or more, even more preferably 1 or more, preferably 15 or less, more preferably 8 or less, even more preferably 4 or less, and still more preferably 3.5 or less.

[20] The non-aqueous oral composition of any one of [1] to

[19] above, wherein the mass ratio of the content of component (B) to the content of component (E) ((B) / (E)) is preferably 0.1 or more, more preferably 0.2 or more, even more preferably 0.3 or more, still more preferably 0.5 or more, and preferably 5 or less, more preferably 2 or less, even more preferably 1.5 or less, and still more preferably 1 or less.

[21] The non-aqueous oral composition of any one of [1] to

[20] above, wherein the mass ratio of the content of component (C) to the content of component (E) ((C) / (E)) is preferably 0.1 or more, more preferably 0.2 or more, even more preferably 0.3 or more, still more preferably 0.35 or more, preferably 8 or less, more preferably 3 or less, even more preferably 2.5 or less, and still more preferably 1.5 or less.

[0057]

[22] The non-aqueous oral composition of any one of [1] to

[21] above, further comprising one or more metal compounds (F) selected from zinc oxide, magnesium oxide, calcium oxide, aluminum oxide, titanium oxide, sodium sulfate, magnesium sulfate, calcium sulfate, calcium chloride, magnesium chloride, zinc chloride, magnesium silicate, and calcium silicate.

[23] The non-aqueous oral composition of

[22] above, wherein component (F) is preferably one or more metal compounds selected from zinc oxide, magnesium oxide, and magnesium sulfate, more preferably one or two metal compounds selected from zinc oxide and magnesium oxide.

[24] The non-aqueous oral composition of

[22] or

[23] above, wherein the content of component (F) is preferably 0.5% by mass or more, more preferably 0.7% by mass or more, even more preferably 0.8% by mass or more, and preferably 7% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less.

[25] The non-aqueous oral composition of any one of

[22] to

[24] above, wherein the mass ratio of the content of component (F) to the content of component (A) ((F) / (A)) is preferably 0.005 or more, more preferably 0.008 or more, even more preferably 0.01 or more, preferably 0.1 or less, more preferably 0.08 or less, and even more preferably 0.05 or less.

[26] The non-aqueous oral composition of any one of

[22] to

[25] above, wherein the mass ratio of the content of component (F) to the content of component (B) ((F) / (B)) is preferably 0.01 or more, more preferably 0.03 or more, even more preferably 0.05 or more, and preferably 0.7 or less, more preferably 0.6 or less, and even more preferably 0.5 or less.

[27] The non-aqueous oral composition of any one of

[22] to

[26] above, wherein the mass ratio ((F) / (C)) of the content of component (F) to the content of component (C) is preferably 0.005 or more, more preferably 0.008 or more, even more preferably 0.01 or more, and preferably 0.3 or less, more preferably 0.2 or less, even more preferably 0.1 or less.

[0058]

[28] The content of silicic anhydride is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, even more preferably 1% by mass or more, preferably 6.9% by mass or less, more preferably 6.5% by mass or less, even more preferably 6% by mass or less, or preferably less than 10% by mass, more preferably less than 7% by mass, even more preferably less than 5% by mass, still more preferably less than 4% by mass, and even more preferably less than 1% by mass, or the non-aqueous oral composition of the present invention is preferably the non-aqueous oral composition of any one of [1] to

[27] above, wherein the content of a non-aqueous solvent having a dielectric constant of 10 or more at 25°C is preferably less than 18% by mass, more preferably 10% by mass or less, even more preferably 6% by mass or less, and still more preferably 3% by mass or less, or the non-aqueous oral composition of the present invention is preferably the non-aqueous oral composition of any one of [1] to [28 ...

[30] The non-aqueous oral composition according to any one of [1] to

[29] above, wherein component (B) and / or component (C) preferably does not have a coating layer.

[0059] The present invention will be described in detail below with reference to the following examples. Unless otherwise specified in the tables, the content of each component is expressed in mass %.

[0060] [Examples 1 to 11, Comparative Examples 1 to 5] Each non-aqueous oral composition was prepared by a conventional method according to the formulation shown in Table 1, and the manufacturing stability was first evaluated according to the method described below. For compositions with evaluation results of Z1 to Z3, no further evaluations were conducted as the product was unsatisfactory. Next, each of the obtained non-aqueous oral compositions was filled into a tube container (Kyodo Printing Co., Ltd., 32φ aluminum / polyethylene tube, 100 g capacity), and then each evaluation was conducted according to the method described below. The results are shown in Table 1.

[0061] <<Evaluation of manufacturing stability>> When the non-aqueous oral compositions were manufactured, they were evaluated according to the following criteria: X: They could be manufactured without any problems Z1: The dispersibility of the ingredients was poor, and they had no shape retention Z2: The reaction of the ingredients progressed during manufacturing, causing bubbles to form Z3: They were partially liquefied, causing liquid separation

[0062] <Evaluation of Foaming Sensation> 1 g of each non-aqueous oral composition was dispensed from the tube container and placed on a toothbrush, followed by brushing for 2 minutes. The foaming sensation during brushing was evaluated according to the following criteria: 5: Bubbles popped with a very pleasant popping sound 4: Bubbles popped with a pleasant popping sound 3: Bubbles popped with a slight popping sound 2: Bubbles were palpable, but no popping sensation was felt 1: Bubbles were not palpable

[0063] <Evaluation of Oily Feeling> 1 g of each non-aqueous oral composition was dispensed from the tube container and placed on a toothbrush, followed by brushing for 2 minutes. The oily feeling during brushing was evaluated according to the following criteria: 5: Not oily at all 4: Not very oily 3: Slightly oily but within acceptable limits 2: Oily but within acceptable limits 1: Very oily

[0064] <Evaluation of Refreshing Feeling> 1 g of each non-aqueous oral composition was dispensed from the tube container and placed on a toothbrush, followed by brushing for 2 minutes. The refreshing feeling in the oral cavity after brushing was evaluated according to the following criteria, using the degree of refreshing feeling as an index: 5: Very refreshing in the mouth 4: Refreshing in the mouth 3: Slightly refreshing in the mouth 2: Not very refreshing in the mouth, but within an acceptable range 1: Not refreshing in the mouth

[0065] <Evaluation of Storage Stability> Each non-aqueous oral composition was filled into a tube container at room temperature (25°C), and then visually evaluated for the degree of swelling of the container during storage in a thermostatic bath at 50°C for the specified period described below. Photographs of the containers after storage in Example 1, Comparative Example 1 (swelling confirmed 10 minutes after filling), and Comparative Example 2 (swelling confirmed 1 hour after filling) are shown in Figure 1. 5: No swelling was observed within 1 month of storage 4: No swelling was observed within 2 weeks of storage 3: No swelling was observed within 1 week of storage 2: Swelling was observed within 1 week of storage 1: Swelling was observed on the day of filling into the tube container, without even needing to be stored in a thermostatic bath

[0066]

Claims

1. A non-aqueous oral composition containing the following components (A) to (E): (A) a non-aqueous solvent having a dielectric constant of less than 10 at 25°C and a melting point of 0°C or lower; (B) an acid that is solid at 25°C; (C) a carbonate; (D) an oil-based gelling agent; and (E) a sugar alcohol that is solid at 25°C.

2. A non-aqueous oral composition as described in claim 1, wherein the solubility of component (E) in water at 25°C is 5% by mass or more and 75% by mass or less.

3. A non-aqueous oral composition as described in claim 1 or 2, wherein the mass ratio ((A) / (E)) of the content of component (A) to the content of component (E) is 0.4 or more and 5 or less.

4. A non-aqueous oral composition according to any one of claims 1 to 3, wherein the mass ratio ((A) / (D)) of the content of component (A) to the content of component (D) is 10 or more and 30 or less.

5. A non-aqueous oral composition according to any one of claims 1 to 4, wherein the mass ratio of the total content of components (B) and (C) to the content of component (A), ({(B) + (C)} / (A)), is 0.2 or more and 3.5 or less.

6. A non-aqueous oral composition according to any one of claims 1 to 5, wherein component (C) contains sodium bicarbonate and sodium carbonate.

7. A non-aqueous oral composition described in any one of claims 1 to 6, wherein the content of component (B) is 6% by mass or more and 25% by mass or less.

8. A non-aqueous oral composition according to any one of claims 1 to 7, wherein the content of anhydrous silicic acid is less than 7 mass%.

9. A non-aqueous oral composition according to any one of claims 1 to 8, wherein the content of a non-aqueous solvent having a relative dielectric constant of 10 or more at 25°C is less than 18 mass%.

10. A non-aqueous oral composition according to any one of claims 1 to 9, further containing one or more metal compounds (F) selected from zinc oxide, magnesium oxide, calcium oxide, aluminum oxide, titanium oxide, sodium sulfate, magnesium sulfate, calcium sulfate, calcium chloride, magnesium chloride, zinc chloride, magnesium silicate, and calcium silicate.

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