Aqueous composition with a sennoside and at least one hydrotrope agent

Abstract

The present invention relates to a cosmetic composition comprising at least one compound according to formula (I) as defined hereinafter, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts in particular organic or mineral basic salts or solvates such as hydrates, at least 8% by weight with respect to the total weight of the composition of at least one hydrotropic agent, and water.

Description

[0001] Aqueous composition with a sennoside and at least one hydrotrope agent

[0002] The present invention relates to a cosmetic composition comprising:

[0003] (a) at least one compound according to formula (I) as defined hereinafter, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts in particular organic or mineral basic salts or solvates such as hydrates,

[0004] (b) at least 8% by weight with respect to the total weight of the composition of at least one hydrotropic agent, and

[0005] (c) water.

[0006] Human skin is composed of two compartments, namely a deep compartment (the dermis) and a surface compartment (the epidermis). The epidermis is in contact with the external environment, and it particularly has the role of protecting the body from dehydration and stress in particular external, chemical or mechanical stress.

[0007] There is still a need for novel cosmetic compositions having advantageous properties, in particular on the skin.

[0008] Sennosides may be advantageous active agents in this aim. Indeed, this type of active agent is known in cosmetics, for example from application JP2002-255733.

[0009] However, sennosides are partially soluble in some solvents such as methanol and acetone (which are not cosmetically acceptable solvents), and are not soluble in water, in particular at ambient temperature. Therefore, they do not allow, per se, the formulation of cosmetic compositions that are stable and applicable on the skin.

[0010] Therefore, the formulator seeks compositions comprising a sennoside such as sennoside A which are stable and applicable in particular topically (i.e. on the skin and / or mucosa).

[0011] Such compositions must furthermore comprise a certain quantity of water, in order to be able to formulate a sennoside such as sennoside A in a wide range of cosmetic substrates including lotions, gels or emulsions.

[0012] In this context, the inventors surprisingly discovered that particular hydrotropic agents allow the solubilization of a sennoside such as sennoside A, and are compatible with a formulation in aqueous medium. Therefore, the aim of the invention is that of providing a cosmetic composition addressing all these issues.

[0013] Indeed, as demonstrated in the examples, the Applicant surprisingly discovered that sennoside A, though insoluble in water, glycols and various oils, is soluble from 0.5% by weight in an aqueous medium comprising at least 8% by weight with respect to the total weight of the composition of at least one hydrotropic agent.

[0014] Thus, the present invention relates to a cosmetic composition comprising:

[0015] (a) at least one compound according to formula (I) as defined hereinafter, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts in particular organic or mineral basic salts or solvates such as hydrates,

[0016] (b) at least 8% by weight with respect to the total weight of the composition of at least one hydrotropic agent, and

[0017] (c) water.

[0018] Preferably, the present invention relates to a cosmetic composition consisting of:

[0019] (a) at least one compound according to formula (I) as defined hereinafter, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts in particular organic or mineral basic salts or solvates such as hydrates,

[0020] (b) at least 8% by weight with respect to the total weight of the composition of at least one hydrotropic agent, and

[0021] (c) water.

[0022] According to the present invention, and unless indicated otherwise: an "alkyl" radical is a linear or branched saturated hydrocarbon radical, in particular Ci-Ce, preferably C1-C4; a "(poly)(hydroxy) (C1-C6) alkyl" radical denotes a Ci-Ce, preferably C1-C4 alkyl radical, optionally substituted by one or more hydroxy radicals, preferably substituted by 1 to 4 hydroxy groups, more particularly between 1 and 3; a "sugar" radical is a monosaccharide or disaccharide radical. As sugar radical, mention may be made of: sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose or lactose;

[0023] "monosaccharide" means a mono-glycoside sugar comprising at least 5 carbon atoms of formula CX(H2O)X, where x is an integer greater than or equal to 5, preferably x is greater than or equal to 6, in particular x is between 5 and 7 inclusive, preferably x = 6. They may be D or L series, and of alpha or beta anomer, as well as one of their salts or their solvates such as hydrates;

[0024] "disaccharide" means a di-glycoside sugar which is a compound consisting of two glycosides bonded together by O-glycosidic bonds, said compounds consisting of two monosaccharides (also referred to as mono-glycosides) as defined above, said monosaccharide units comprising at least 5 carbon atoms, preferably 6, particularly the mono-glycoside units are bonded together at 1 ,4 or 1 ,6, in a (alpha) or p (beta) anomer, each glycoside unit being capable of being L or D series, as well as one of its salts or its solvates such as hydrates. A disaccharide is more particularly a polymer formed from two glycosides (or monosaccharides) having the general formula: -[Cx(H2O)y)]2- or -[(CH2O)x]2-, where x is an integer greater than or equal to 5, preferably x is greater than or equal to 6, in particular x is between 5 and 7 inclusive, preferably x = 6, and y is an integer which represents x - 1 ;

[0025] "organic or mineral basic salt' means a basic salt or alkaline agent such as alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, ammonia, amines, alkanolamines or so-called "basic" amino acid salts such as lysine or arginine;

[0026] "skin" means facial skin and / or body skin, and the scalp;

[0027] "appendages" means eyelashes, eyebrows, nails and hair, and particularly eyelashes and hair; hereinafter, and unless indicated otherwise, the ranges of values are inclusive, in particular in the expressions "between and" and "ranging from ... to ..."; moreover, the expression "at least one" used in the present description is equivalent to the expression "one or more".

[0028] The invention also relates to a method for care of the skin and / or mucosa comprising application of the composition according to the invention on the skin and / or mucosa.

[0029] The invention also relates to the use of a composition according to the invention for care of the skin and / or mucosa.

[0030] The invention also relates to a final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight, preferably from 60% to 99%, and more preferably from 70% to 95% with respect to the total weight of the composition of a composition as described above (i.e. comprising ingredients a) to c)). This final composition corresponds in particular to the marketed final cosmetic product.

[0031] Compound according to formula (I) (compound (a))

[0032] The composition according to the invention comprises at least one compound according to formula (I) or one of its optical isomers, cis-trans isomers (such as an alpha or beta anomer), tautomers or one of its salts in particular organic or mineral basic salts or one of its solvates such as hydrates:

[0033] [Chem 1] wherein:

[0034] - R’ and R” are identical or different, preferably identical, and represent an H or a monosaccharide or a polysaccharide including up to 20 sugar units, preferably up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide optionally being substituted by an obligatorily free hydroxyl group, and optionally one or more optionally protected amine function(s), and said monosaccharide or polysaccharide optionally being substituted on its -CH2OH group by a -C(O)-CC>2H group;

[0035] - R represents H or -C-(O)-O-Ri or -Alk-X-R1 , preferably -C-(O)-O-Ri or Alk-O-Ri, where X is O, S or -NRi, preferably O; Ri being H or a saturated or unsaturated hydrocarbon chain, preferably saturated C1-C6, more preferably R1 corresponds to H, and Aik corresponds to a Ci-Ce alkylene group, preferably -CH2-.

[0036] Advantageously, R’ and R” are identical or different and represent a monosaccharide or a polysaccharide containing up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide having at least one obligatorily free hydroxyl function and / or optionally one or more obligatorily protected amine function(s).

[0037] Advantageously, the monosaccharide is chosen from D-glucose, D-galactose, D- mannose, D-xylose, D-lyxose, L-fucose, L-arabinose, L-rhamnose, D-glucuronic acid, D- galacturonic acid, D-iduronic acid, N-acetyl-D-glucosamine and N-acetyl-D-galactosamine. The monosaccharide advantageously denotes D-glucose, L-rhamnose, D-xylose, N-acetyl- D-glucosamine or L-fucose, and more preferably D-glucose.

[0038] Advantageously, the polysaccharide containing up to 6 sugar units is chosen from D-maltose, D-lactose, D-cellobiose, D-maltotriose, a disaccharide associating a uronic acid chosen from D-iduronic acid or D-glucuronic acid with a hexosamine chosen from D- galactosamine, D-glucosamine, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, a disaccharide associating L-rhamnose and D-galactose, an oligosaccharide containing at least one xylose which can advantageously be chosen from xylobiose, methyl-p- xylobioside, xylotriose, xylotetraose, xylopentaose and xylohexaose and in particular xylobiose which is composed of two xylose molecules bonded by a 1-4 bond.

[0039] More preferably, R’ and R” are identical or different and represent a monosaccharide chosen from D-glucose, D-xylose, L-fucose, L-rhamnose, D-galactose and D-maltose, preferably D-glucose.

[0040] The monosaccharide or polysaccharide of R’ and / or R” may be substituted on one or more hydroxymethyl residue(s) by a -C(O)-COOH group.

[0041] Preferably, the compound according to formula (I) or one of its optical isomers, cistrans isomers (such as an alpha or beta anomer), tautomers or one of its salts in particular organic or mineral basic salts or one of its solvates such as hydrates, is chosen from sennosides A, B, C, D, E and F, preferably it is chosen from sennosides A and B, more preferably the compound according to formula (I) is sennoside A or one of its salts.

[0042] The compound according to formula (I) or one of its optical isomers, cis-trans isomers (such as an alpha or beta anomer), tautomers or one of its salts in particular organic or mineral basic salts or one of its solvates such as hydrates, preferably sennoside A or one of its salts, is present in solubilized form in the composition. "In solubilized form" means that said compound does not form crystals visible to the naked eye in the composition. Sennoside A (C42H38O20) (or (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5- [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4- hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H- anthracene-2-carboxylic acid under its IIIPAC name) is the chemical compound according to the following formula (I’):

[0043] [Chem 2]

[0044] Its CAS number is 81-27-6. It is a derivative of anthraquinone, which is found in plants of the Senna genus. It is typically presented in the form of a very hygroscopic yellow powder.

[0045] Sennoside A has 4 pKa, the values of which are pKa1 = 3.3, pKa2 = 3.9, pKa3 = 7.5 and its final pKa (pKa4) is equal to 8.2.

[0046] The compound according to formula (I), preferably sennoside A may also be presented in salt form. "Salt" means a cosmetically acceptable salt, i.e. compatible with application on the skin, mucosa and / or skin appendages. The salt of compound according to formula (I), preferably the salt of sennoside A, may be an alkali metal or alkaline-earth salt, preferably a calcium, magnesium, sodium or potassium salt.

[0047] Typically, the salt of compound according to formula (I), preferably the sennoside salt such as the salt of sennoside A, may exist once the compound has been introduced into the composition. Indeed, the compound according to (I) is introduced in non-salified form into the composition.

[0048] Sennoside A is for example marketed by INTERCHIM under the name Sennoside A. Preferably, the composition comprises between 0.1 and 5% by weight of the compound according to formula (I) or one of its optical isomers, cis-trans isomers (such as an alpha or beta anomer), tautomers or one of its salts in particular organic or mineral basic salts or one of its solvates such as hydrates, with respect to the total weight of the composition, preferably between 0.2 and 4% by weight, preferably between 0.3 and 3% by weight, preferably between 0.4 and 1% by weight.

[0049] Preferably, the composition comprises between 0.1 and 10% by weight of sennoside A or one of its salts with respect to the total weight of the composition, preferably between 0.2 and 5% by weight, preferably between 0.3 and 3% by weight, preferably between 0.4 and 1 % by weight.

[0050] Hydrotropic agent

[0051] The composition according to the invention comprises at least 8% by weight with respect to the total weight of the composition of at least one hydrotropic agent.

[0052] Preferably, the composition according to the invention comprises at least 8% by weight with respect to the total weight of the composition of at least two hydrotropic agents.

[0053] Preferably, the hydrotropic agents are cosmetically acceptable hydrotropic agents.

[0054] "Hydrotrope" or "hydrotropic agent" means a water-soluble compound which has an amphiphilic molecular structure and which is capable of considerably increasing the solubility of organic molecules slightly soluble in water. A hydrotrope is different from a polymer (i.e. chemical compound that is constituted of repetitions of a structural unit and having a molar mass greater than 10 000 g / mol). A hydrotrope is a small molecule; typically it presents a molar mass comprised between 1 and 600 g / mol.

[0055] Hydrotropes are like surfactants, but are distinguished by their hydrophobic part which is shorter and does not make it possible to induce spontaneous autoagreggation. Unlike surfactants, these compounds do not have a critical micellar concentration.

[0056] Among the hydrotropic agents known from the prior art, mention may be made of sodium 1 ,3-benzenedisulfonate, sodium benzoate, sodium 4-pyridinecarboxylate (sodium PCA), sodium salicylate, sodium benzene sulfonate, caffeine, sodium p-toluene sulfonate, sodium butyl monoglycolsulfate, 4-aminobenzoic acid and its HCI salt, sodium cumene sulfonate, N,N-diethylnicotinamide, N-picolylnicotinamide, N-allylnicotinamide, 2- methacryloyloxyethyl phosphorylcholine, resorcinol, urea, hydroxyethyl urea, N,N-dimethyl urea, pyrogallol, N-picolylacetamide 3.5, procaine hydrochloride, proline hydrochloride, niacinamide (or nicotinamide), pyridine, 3-picolylamine, ibuprofen sodium, sodium xylene sulfonate, ethyl carbamate, pyridoxal hydrochloride, sodium benzoate, 2-pyrrolidone, ethylurea, N,N-dimethylacetamide, N-methylacetamide or isoniazide. A list of hydrotropes is detailed in the following publications: Lee J. et al, "Hydrotropic

[0057] Solubilization of Paclitaxel: Analysis of Chemical Structures for Hydrotropic Property", Pharmaceutical Research, Vol. 20, No. 7, 2003, Lee S. et al, "Hydrotropic Polymers: Synthesis and Characterization of Polymers Containing Picolylnicotinamide Moieties", Macromolecules, 36, 2248-2255, 2003, and Hodgon T.K., Kaier E.W., "Hydrotropic Solutions", Current Opinion in Colloid and Interface Science, 12, 121-128, 2007.

[0058] Cosmetically acceptable hydrotropes denote hydrotropes which are compatible with a cosmetic application, i.e. application on the skin, mucosa and / or skin appendages.

[0059] Preferably, the suitable hydrotrope according to the invention is chosen from the following hydrotropes and mixtures thereof:

[0060] [Table 1]

[0061] Preferably, the composition according to the invention comprises at least one hydrotropic agent chosen from caffeine, niacinamide and mixtures thereof.

[0062] Preferably, the composition according to the invention comprises a mixture of caffeine and niacinamide.

[0063] Preferably, caffeine and niacinamide are present in the composition according to the invention in a caffeinemiacinamide weight ratio between 0.5 and 1.5, preferably between 0.8 and 1.

[0064] Preferably, the quantity of hydrotropic agent(s) in the composition according to the invention is between 8 and 20% by weight with respect to the total weight of the composition, preferably between 8 and 15% by weight, preferably between 8 and 11 % by weight.

[0065] Preferably, the weight ratio of hydrotropic agent(s): sennoside A or one of its salts in the composition according to the invention is at least 16:1.

[0066] Water

[0067] The composition according to the invention comprises water.

[0068] The water used may be sterile demineralized water and / or floral water such as rose water, cornflower water, chamomile water or linden water, and / or a spring or natural mineral water, such as VITTEL water, LUCAS water or LA ROCHE POSAY water.

[0069] The composition preferably comprises at least 30% by weight of water, with respect to the total weight of the composition, preferably at least 50% by weight, preferably at least 60% by weight, and preferably at least 70% by weight. The composition preferably comprises from 30% to 98% by weight of water with respect to the total weight of the composition, more preferably from 50% to 97% by weight, even more preferably from 70% to 95% by weight.

[0070] Preferably, the composition according to the invention has a pH lower than the 4thpKa of the compound according to formula (I), preferably lower than the 3rdpKa of the compound according to formula (I). Preferably, the pH of the composition according to the invention is between 5.0 and 7.0, preferably between 6.0 and 7.0.

[0071] Indeed, in this specific case, sennoside A is insoluble in water at its native pH, i.e. around 4.3. It is known that raising the pH of a molecule beyond its final pKa makes the molecule soluble. However, as sennoside A has 4 pKa and its final pKa is equal to 8.2, such a pH results in the formulation of sennoside A beyond 8.3, which is incompatible with topical cosmetic application, in particular on the skin and / or mucosa. Indeed, topical cosmetic compositions, in particular applicable on the skin and / or mucosa, must have an acceptable physiological pH, i.e. between 5.0 and 7.0.

[0072] Preferably, the composition according to the invention has a pH lower than 8.3, preferably lower than 7.0.

[0073] Preferably, the present invention relates to a cosmetic composition comprising, preferably consisting of:

[0074] (a) sennoside A or one of its salts,

[0075] (b) at least 8% by weight with respect to the total weight of the composition of at least two hydrotropic agents, and

[0076] (c) water.

[0077] Preferably, the present invention relates to a cosmetic composition comprising, preferably consisting of:

[0078] (a) sennoside A or one of its salts,

[0079] (b) at least 8% by weight with respect to the total weight of the composition of a mixture of caffeine and niacinamide, and

[0080] (c) water.

[0081] The composition according to the invention may also contain usual ingredients in the cosmetics field, such as preservatives, perfumes, fillers, oils, waxes, pasty fats, sun protection filters or UV filters, odor absorbers, dyestuffs, alkaline agents, sequestering agents, or active agents. The quantities of these various ingredients are conventionally the quantities used in the field considered, for example from 0.01 to 20% of the total weight of the composition. These ingredients, depending on their nature, may be introduced into the oily phase and / or into the aqueous phase.

[0082] Obviously, those skilled in the art will take care to choose the optional compound(s) to add to the composition according to the invention and their quantities in such a way that the advantageous properties intrinsically associated with the composition according to the invention are not altered, or are not substantially altered, by the envisaged addition.

[0083] The composition according to the invention may be obtained conventionally by those skilled in the art.

[0084] The invention also relates to a final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight with respect to the total weight of the composition of a composition as described above (i.e. comprising ingredients a) to c)), preferably from 60 to 99% by weight, more preferably from 70 to 95% by weight. The final composition corresponds in particular to the marketed final cosmetic product, based on sennoside. Cosmetically acceptable medium means a medium compatible with the skin and / or its appendages.

[0085] The invention also relates to a method for care of the skin and / or mucosa comprising application of the composition according to the invention or the final composition according to the invention on the skin and / or mucosa.

[0086] The invention also relates to the use of a composition according to the invention or the final composition according to the invention for care of the skin and / or mucosa.

[0087] The following examples make it possible to understand the invention better, without being in any way limitative. The raw materials are referred to with the chemical or INCI name thereof. The amounts indicated are as a % by weight of raw materials with respect to the total weight of the composition (% w / w), unless specified otherwise.

[0088] Examples Example 1 : preparation of compositions according to the invention and evaluation compared to comparative compositions

[0089] Compositions according to the invention are compared with counter-examples.

[0090] Procedure

[0091] The compositions in Tables 2 and 3 below are prepared as follows:

[0092] A solution of caffeine and niacinamide mixture is produced in water based on a content of 4% or 5% caffeine and 5% niacinamide and QS to 100% with water. Sennoside A at 0.5% by weight is sprinkled into the beaker with the hydrotrope solution with different hydrotrope contents under magnetic stirring and heated to a maximum temperature of 50°C.

[0093] The stability of the compositions is evaluated after 2 months at 4°C (2M at 4°C) and after 2 months at ambient temperature (approximately 20°C) (2M at AT).

[0094] Caffeine: niacinamide weight ratio = 1 [Table 2]

[0095] AT = ambient temperature (approximately 20°C)

[0096] Caffeinemiacinamide weight ratio = 0.8

[0097] [Table 3]

[0098] AT = ambient temperature (approximately 20°C)

[0099] The results show that sennoside A is insoluble in water. However, by adding a mixture of hydrotropic agents caffeine and niacinamide in a total amount greater than or equal to 8% by weight with respect to the total weight of the composition, in particular for a caffeinemiacinamide weight ratio between 0.8 and 1 , sennoside A becomes soluble.

[0100] The sennoside A solutions remain clear over time, even at a pH of 4.7 (pH at which sennoside A is not water-soluble).

Claims

CLAIMSCosmetic composition comprising:(a) at least one compound according to formula (I) or one of its optical isomers, cistrans isomers, tautomers or one of its salts in particular organic or mineral basic salts or its solvates such as hydrates:[Chem 1]wherein:- R’ and R” are identical or different, preferably identical, and represent an H or a monosaccharide or a polysaccharide including up to 20 sugar units, preferably up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide optionally being substituted by an obligatorily free hydroxyl group, and optionally one or more optionally protected amine function(s), and said monosaccharide or polysaccharide optionally being substituted on its - CH2OH group by a -C(O)-CC>2H group;- R represents H or -C-(O)-O-Ri or -Alk-X-R1 , preferably -C-(O)-O-Ri or Alk-O-Ri, where X is O, S or -NRi, preferably O; R1 being H or a saturated or unsaturated hydrocarbon chain, preferably saturated C1-C6, more preferably R1 corresponds to H, and Aik corresponds for a Ci-Ce alkylene group, preferably -CH2-,(b) at least 8% by weight with respect to the total weight of the composition of at least one hydrotropic agent, and(c) water.

2. Composition according to claim 1 , wherein the compound according to formula (I) is such that R’ and R” are identical and represent a monosaccharide chosen from D-glucose, D-galactose, D-mannose, D-xylose, D-lyxose, L-fucose, L-arabinose, L- rhamnose, D-glucuronic acid, D-galacturonic acid, D-iduronic acid, N-acetyl-D-glucosamine and N-acetyl-D-galactosamine, preferably chosen from D-glucose, L-rhamnose, D-xylose, N-acetyl-D-glucosamine and L-fucose, and more preferably D-glucose; preferably the compound according to formula (I) or one of its optical isomers, cis-trans isomers, tautomers or one of its salts in particular organic or mineral basic salts or one of its solvates such as hydrates, is chosen from sennosides A, B, C, D, E and F, preferably it is chosen from sennosides A and B.

3. Composition according to one of the preceding claims, wherein the compound according to formula (I) is sennoside A or one of its salts.

4. Composition according to one of the preceding claims, which comprises between 0.1 and 10% by weight of compound according to formula (I) or one of its salts with respect to the total weight of the composition, preferably between 0.2 and 5% by weight, preferably between 0.3 and 3% by weight, preferably between 0.4 and 1% by weight.

5. Composition according to one of the preceding claims, wherein the hydrotropic agent is chosen from niacinamide, caffeine, urea, sodium 4-pyridinecarboxylate (sodium PCA), sodium salicylate, hydroxyethyl urea and mixtures thereof; preferably, the hydrotropic agent is chosen from caffeine, niacinamide and mixtures thereof.

6. Composition according to one of the preceding claims, which comprises at least 8% by weight with respect to the total weight of the composition of at least two hydrotropic agents.

7. Composition according to one of the preceding claims, wherein the quantity of hydrotropic agent(s) is between 8 and 20% by weight with respect to the total weight of the composition, preferably between 8 and 15% by weight, preferably between 8 and 11 % by weight.

8. Composition according to one of the preceding claims, wherein the hydrotropic agent is a mixture of caffeine and niacinamide, preferably in a caffeinemiacinamide weight ratio between 0.5 and 1.5, preferably between 0.8 and 1.

9. Composition according to one of the preceding claims, which comprises at least 30% by weight of water with respect to the total weight of the composition, preferably at least 50% by weight, preferably at least 60% by weight, preferably at least 70% by weight; preferably comprises from 30% to 98% water by weight with respect to the total weight of the composition, more preferably from 50% to 97% by weight, even more preferably from 70% to 95% by weight.

10. Composition according to one of the preceding claims, which has a pH lower than 8.3, preferably lower than 7.0, preferably between 5.0 and 7.0, preferably between 6.0 and 7.0.

11. Composition according to one of the preceding claims, which consists of:(a) at least one compound according to formula (I) as defined hereinafter, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts in particular organic or mineral basic salts or solvates such as hydrates,(b) at least 8% by weight with respect to the total weight of the composition of at least one hydrotropic agent, and(c) water.

12. Final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight, preferably from 60% to 99% by weight, more preferably from 70% to 95% by weight with respect to the total weight of the composition of a composition according to claims 1 to 11.

13. Method for care of the skin and / or mucosa comprising application of the composition according to one of the preceding claims on the skin and / or mucosa.

14. Use of a composition according to one of claims 1 to 11 or 12 for care of the skin and / or mucosa.

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