Cosmetic

Abstract

A cosmetic according to one aspect of the present invention comprises: (A) a C14-C22 higher alcohol; (B) a hydrophilic polyoxyethylene alkyl ether; (C) a glycerin monoalkyl ether; and (D) a pyrimidylpyrazole compound represented by general formula (1) or a pharmacologically acceptable salt thereof. (In general formula (1), R1, R3, R4, and R6 each independently represent a C1-C3 alkyl group, and R2 and R5 each independently represent a hydrogen atom or a C1-C3 alkyl group.)

Description

cosmetics

[0001] The present invention relates to a cosmetic preparation.

[0002] Oil-in-water emulsion cosmetics are preferred as cosmetic bases that provide a fresh feeling when used, because the external phase (continuous phase), i.e., the phase that first comes into contact with the skin, is an aqueous phase. Various attempts have been made to make cosmetics that have an even better feeling when used by improving these properties of oil-in-water emulsion bases.

[0003] For example, an oil-in-water emulsion composition has been proposed that has a moist and non-sticky feel when used, and can impart excellent firmness even when a salt-type whitening agent is incorporated, without decreasing stability over time (see Patent Document 1).

[0004] It is known that the feeling of firmness in the skin can be felt more effectively when cosmetics contain mainly solid oils, film-forming agents, etc. However, the excessive use of solid oils, etc., particularly in oil-in-water emulsion cosmetics, can lead to problems such as a loss of the fresh feel when used, good spreadability, and good skin compatibility.

[0005] JP 2012-31088 A

[0006] In view of the above, an object of one aspect of the present invention is to provide a cosmetic that is non-sticky, blends well with the skin, and provides a moist feeling.

[0007] In order to solve the above-mentioned problems, one aspect of the cosmetic preparation according to the present invention is characterized by containing (A) a higher alcohol having 14 to 22 carbon atoms, (B) a hydrophilic polyoxyethylene alkyl ether, (C) a glycerin monoalkyl ether, and (D) a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof:

[0008] (In the general formula (1), R １ , R ３ , R ４ , and R ６ each independently represents an alkyl group having 1 to 3 carbon atoms; R ２ and R ５each independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.

[0009] According to one aspect of the present invention, it is possible to provide a cosmetic that is non-sticky, blends well with the skin, and provides a moist feeling.

[0010] Hereinafter, embodiments of the present invention will be described in detail. Note that the embodiments are not limited by the following description and can be modified as appropriate within the scope of the present invention. Furthermore, in this specification, unless otherwise specified, the term "to" indicating a range of values ​​means that the values ​​before and after it are included as the lower and upper limits.

[0011] (Cosmetic) A cosmetic according to one embodiment contains (A) a higher alcohol having 14 to 22 carbon atoms, (B) a hydrophilic polyoxyethylene alkyl ether, (C) a glycerin monoalkyl ether, and (D) a pyrimidylpyrazole compound represented by general formula (1) or a pharmacologically acceptable salt thereof, and may further contain other ingredients as necessary.

[0012] The present inventors have found that while the oil-in-water emulsion composition of Patent Document 1 has a fresh, non-sticky feel when used and provides excellent firmness, it has the problem of poor compatibility with the skin upon application. In contrast, a cosmetic preparation according to one embodiment is non-sticky, and has excellent compatibility with the skin and a moisturizing feel.

[0013] <(A) Higher Alcohol Having 14 to 22 Carbon Atoms> The higher alcohol having 14 to 22 carbon atoms (hereinafter, may be referred to as "component (A)") is not particularly limited as long as it has 14 to 22 carbon atoms and can be appropriately selected depending on the purpose. However, from the viewpoint of gel formation, it is preferable that the higher alcohol has a linear saturated alkyl chain.

[0014] The number of carbon atoms in the alkyl chain of component (A) is not particularly limited as long as it is 14 to 22, and can be selected appropriately depending on the purpose, but 18 to 22 is preferred.

[0015] Specific examples of component (A) include myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, and oleyl alcohol. These may be used alone or in combination of two or more. Among these, behenyl alcohol is preferred as component (A).

[0016] The component (A) may be synthesized by a known method, or a commercially available product may be used. Commercially available products of component (A) include myristyl alcohols such as NAA-43 (manufactured by NOF Corporation), Conol 1495 (manufactured by New Japan Chemical Co., Ltd.), and Hynol 14SS (manufactured by Kokyu Alcohol Kogyo Co., Ltd.); cetyl alcohols such as NAA-44 (manufactured by NOF Corporation), Conol 1695 (manufactured by New Japan Chemical Co., Ltd.), Cetanol, and Hynol 16SS (manufactured by Kokyu Alcohol Kogyo Co., Ltd.); stearyl alcohols such as NAA-45 and NAA-46 (all manufactured by NOF Corporation), Conol 30F and Conol 30SS (all manufactured by New Japan Chemical Co., Ltd.), stearyl alcohol, and Hynol 18SS (all manufactured by Kokyu Alcohol Kogyo Co., Ltd.); behenyl alcohols such as behenyl alcohol (manufactured by Kokyu Alcohol Kogyo Co., Ltd.), NAA-422 (manufactured by NOF Corporation), NIKKOL Behenyl Alcohol 65, and NIKKOL Behenyl Alcohol 80 (manufactured by Nikko Chemicals Co., Ltd.); NOFABLE Examples of oleyl alcohols include AO-85S (manufactured by NOF Corporation), oleyl alcohol VP (manufactured by Kokyu Alcohol Kogyo Co., Ltd.), Rikacol 85BJ, Rikacol 90B, and Rikacol 90BHR (all manufactured by New Japan Chemical Co., Ltd.).

[0017] The content of component (A) in the cosmetic according to one embodiment is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.01% by mass to 10% by mass, more preferably 0.01% by mass to 5% by mass, and even more preferably 0.1% by mass to 1% by mass, relative to the total mass of the cosmetic.

[0018] <(B) Hydrophilic Polyoxyethylene Alkyl Ether> The hydrophilic polyoxyethylene alkyl ether (hereinafter, sometimes referred to as "component (B)") has a structure in which an alkyl chain and a polyoxyethylene chain are bonded via an ether bond, and exhibits hydrophilic properties.

[0019] The alkyl chain of component (B) is not particularly limited and can be appropriately selected depending on the purpose, and may be a linear alkyl chain or a branched alkyl chain. Furthermore, the alkyl chain of component (B) may be a saturated alkyl chain or an unsaturated alkyl chain. Among these, a linear saturated alkyl chain is preferred for component (B) from the viewpoint of gel formation.

[0020] In the cosmetic preparation according to one embodiment, "hydrophilic" means that the HLB, determined by the relative strength of the hydrophilic group and the hydrophobic group, is greater than 10.

[0021] The number of carbon atoms in the alkyl chain of component (B) is not particularly limited and can be selected appropriately depending on the purpose, but 16 to 22 is preferred, and 18 to 22 is more preferred.

[0022] The average number of moles of ethylene oxide added in the polyoxyethylene chains of component (B) is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 10 to 30 moles, and more preferably 15 to 25 moles.

[0023] Specific examples of component (B) include polyoxyethylene (10) stearyl ether, polyoxyethylene (11) stearyl ether, polyoxyethylene (20) stearyl ether, polyoxyethylene (30) stearyl ether, polyoxyethylene (10) behenyl ether, polyoxyethylene (20) behenyl ether, and polyoxyethylene (30) behenyl ether. These may be used alone or in combination of two or more. Among these, polyoxyethylene (20) stearyl ether and polyoxyethylene (20) behenyl ether are preferred. The number in parentheses indicates the average number of moles of ethylene oxide added in the polyoxyethylene chain.

[0024] Component (B) may be synthesized by a known method as appropriate, or a commercially available product may be used. Examples of commercially available products of component (B) include polyoxyethylene stearyl ethers such as the EMALEX 600 series (manufactured by Nippon Emulsion Co., Ltd.) and the NIKKOL BS series (manufactured by Nikko Chemicals Co., Ltd.); and polyoxyethylene behenyl ethers such as the EMALEX BHA series (manufactured by Nippon Emulsion Co., Ltd.) and the NIKKOL BB series (manufactured by Nikko Chemicals Co., Ltd.).

[0025] The content of component (B) in the cosmetic according to one embodiment is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.01% by mass to 10% by mass, more preferably 0.01% by mass to 5% by mass, and even more preferably 0.1% by mass to 1% by mass, relative to the total mass of the cosmetic.

[0026] <(C) Glycerin Monoalkyl Ether> Glycerin monoalkyl ether (hereinafter, sometimes referred to as "component (C)") has a structure in which an alkyl chain and glycerin are bonded via an ether bond.

[0027] The alkyl chain of component (C) is not particularly limited and can be appropriately selected depending on the purpose, and may be a linear alkyl chain or a branched alkyl chain. Furthermore, the alkyl chain of component (C) may be a saturated alkyl chain or an unsaturated alkyl chain. Among these, a linear saturated alkyl chain is preferred for component (C) from the viewpoint of gel formation.

[0028] The number of carbon atoms in the alkyl chain of component (C) is not particularly limited and can be selected appropriately depending on the purpose, but 16 to 22 carbon atoms is preferred, and 16 to 18 carbon atoms is even more preferred.

[0029] Specific examples of component (C) include glycerin monocetyl ether (chimyl alcohol) and glycerin monostearyl ether (batyl alcohol). These may be used alone or in combination of two or more. Among these, glycerin monostearyl ether is preferred.

[0030] Component (C) may be synthesized by a known method as appropriate, or a commercially available product may be used. Examples of commercially available products of component (C) include glycerin monocetyl ether such as NIKKOL Chimyl Alcohol 100 (manufactured by Nikko Chemicals Co., Ltd.), NIKKOL Batyl Alcohol 100, and NIKKOL Batyl Alcohol EX (both manufactured by Nikko Chemicals Co., Ltd.).

[0031] The content of component (C) in the cosmetic according to one embodiment is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.01% by mass to 10% by mass, more preferably 0.01% by mass to 5% by mass, and even more preferably 0.01% by mass to 0.1% by mass, relative to the total mass of the cosmetic.

[0032] <(D) Pyrimidylpyrazole Compound Represented by General Formula (1) or a Pharmacologically Acceptable Salt Thereof> The pyrimidylpyrazole compound represented by general formula (1) or a pharmacologically acceptable salt thereof (hereinafter, sometimes referred to as "component (D)") has very low cytotoxicity and can also act as a skin whitening agent.

[0033] In general formula (1), R １ , R ３ , R ４ , and R ６ Each independently represents an alkyl group having 1 to 3 carbon atoms. In one embodiment, R １ , R ３ , R ４ , and R ６ The "C1-C3 alkyl group" is a linear, branched, or cyclic saturated hydrocarbon group having 1 to 3 carbon atoms. １ , R ３ , R ４ , and R ６ may be different alkyl groups having 1 to 3 carbon atoms, or may be the same alkyl group having 1 to 3 carbon atoms.

[0034] R １ , R ３ , R ４ , and R ６Examples of the alkyl group having 1 to 3 carbon atoms represented by R include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, and a cyclopropyl group. １ , R ３ , R ４ , and R ６ The alkyl group having 1 to 3 carbon atoms represented by is preferably a methyl group or an ethyl group, more preferably a methyl group.

[0035] In general formula (1), R ２ and R ５ Each independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms. ２ and R ５ The "C1-C3 alkyl group" is a linear, branched, or cyclic saturated hydrocarbon group having 1 to 3 carbon atoms. ２ and R ５ may be different hydrogen atoms or alkyl groups having 1 to 3 carbon atoms, or may be the same hydrogen atom or alkyl groups having 1 to 3 carbon atoms.

[0036] R ２ and R ５ Examples of the alkyl group having 1 to 3 carbon atoms represented by R include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, and a cyclopropyl group. ２ and R ５ is preferably a hydrogen atom.

[0037] Examples of the pharmacologically acceptable salt of the pyrimidylpyrazole compound represented by general formula (1) include inorganic acid salts such as hydrochloride, hydrobromide, sulfate, and phosphate; and organic acid salts such as acetate, propionate, citrate, lactate, oxalate, maleate, fumarate, succinate, tartrate, and methanesulfonate.

[0038] The pyrimidylpyrazole compound represented by the general formula (1) may be synthesized by a known method or may be a commercially available product.

[0039] Representative synthesis examples of the pyrimidylpyrazole compound represented by general formula (1) are described below, but the synthesis is not limited thereto. Examples of synthesis examples of the pyrimidylpyrazole compound represented by general formula (1) include a synthesis method using the reaction shown in the following Scheme 1. The reaction shown in the following Scheme 1 can be carried out in accordance with the methods described in, for example, JP-A-62-000404, Dharmpal S. Dodd et al., Tetrahedron Letters, Volume 45, Issue 22, 2004, pp. 4265-4267, Gazzetta Chemica Italiana, Vol. 93, Parte I, 1963, p. 100, etc.

[0040]

[0041] In Scheme 1, the reaction of the hydrazine compound represented by the general formula (2) with the 1,3-dicarbonyl compound represented by the general formula (3a) or the 1-sulfonyl-3-carbonyl compound represented by the general formula (3b) can be carried out in a suitable solvent such as methanol, in the presence of an acid catalyst such as hydrochloric acid or acetic acid, and with heating as necessary.

[0042] The pharmacologically acceptable salt of the pyrimidylpyrazole compound represented by general formula (1) may be appropriately synthesized by a known method, or may be a commercially available product.An example of the synthesis of the pharmacologically acceptable salt of the pyrimidylpyrazole compound represented by general formula (1) includes a method of converting the pyrimidylpyrazole compound represented by general formula (1) into an acid addition salt appropriately selected from known methods.The acid used in the method of converting into an acid addition salt includes, for example, inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, etc.; organic acids such as acetic acid, propionic acid, citric acid, lactic acid, oxalic acid, maleic acid, fumaric acid, succinic acid, tartaric acid, methanesulfonic acid, etc.

[0043] The hydrazine compound represented by general formula (2) used as a starting material in Scheme 1 may be synthesized by a known method or may be a commercially available product. An example of a synthesis of the hydrazine compound represented by general formula (2) is a synthesis method using the reaction shown in Scheme 2 below. The reaction shown in Scheme 2 below can be carried out, for example, in accordance with the method described in JP-A-8-208620.

[0044]

[0045] The hydrazine compound represented by general formula (2) used as a starting material in Scheme 1 can also be synthesized from a pyrimidine compound represented by general formula (5) having a leaving group Z by the reaction shown in Scheme 3 below. Examples of the leaving group Z in the pyrimidine compound represented by general formula (5) include halogen. The reaction shown in Scheme 3 below can be carried out, for example, as described in Takeo Naito et al., Chemical and Pharmaceutical Bulletin, 1969, Vol. 17, No. 7, pp. 1467-1478; Kaname Takagi et al., Chemical and Pharmaceutical Bulletin, 1963, Vol. 11, No. 11, pp. 1382-1388; and Kenzo Shirakawa, Pharmaceutical Journal, 1953, Vol. 73, No. 6, p. This can be carried out in accordance with the method described in, for example, J. Am. Chem. Soc. 2002, 635-639.

[0046]

[0047] Other compounds used in the reactions of Schemes 1 to 3 may be synthesized by known methods or may be commercially available products.

[0048] In the reactions of Schemes 1 to 3, when a functional group is present in the molecule and this functional group interferes with or is likely to interfere with the reaction, it is preferable to use an appropriate protecting group to efficiently proceed with the reaction. The protecting group can be used, for example, in accordance with the method described in Greene's Protective Groups in Organic Synthesis by Theodora W. Greene and Peter G. M. Wuts.

[0049] In the reactions of Schemes 1 to 3, when isomers such as conformational isomers, geometric isomers, or optical isomers exist, they can be obtained as pure isomers or geometric isomers by appropriately selecting raw materials and reaction conditions and performing separation procedures. The pyrimidylpyrazole compound represented by general formula (1) or a pharmacologically acceptable salt thereof also includes pure isomers and mixtures thereof.

[0050] The pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof includes R １ , R ３ , R ４ , and R ６ is a methyl group, and R ２ and R ５ is a hydrogen atom, 2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine hydrochloride (also referred to as "dimethylpyrazolyldimethylpyrimidine hydrochloride") is particularly preferred.

[0051] In a cosmetic according to one embodiment, the content of component (D) is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.1% by mass to 1.5% by mass, more preferably 0.1% by mass to 1% by mass, and even more preferably 0.5% by mass to 1% by mass, relative to the total mass of the cosmetic. When the content of component (D) is 0.1% by mass or more, non-stickiness and good compatibility with the skin can be suitably improved. Furthermore, since excessive incorporation of component (D) may not achieve significant effects commensurate with the increased amount and may have an impact on formulation design, usability, and the like, the content of component (D) is preferably 1.5% by mass or less.

[0052] <<Mass Ratio [(D) / (A+B+C)]>> The mass ratio [(D) / (A+B+C)] of the content (% by mass) of the component (D) to the total content (% by mass) of the component (A), the content (% by mass) of the component (B), and the content (% by mass) of the component (C) is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.1 to 3, and more preferably 0.2 to 2.5. When the mass ratio [(D) / (A+B+C)] is 0.1 to 3 or more, the product is non-sticky, blends well with the skin, and provides a moist feeling.

[0053] <Other Components> The cosmetic preparation according to one embodiment may contain other components in addition to the component (A), the component (B), the component (C), and the component (D).

[0054] The other components are not particularly limited as long as they do not impair the effects of the cosmetic composition according to one embodiment, and can be selected appropriately depending on the purpose. Examples of the other components include components used in external skin preparations such as cosmetics and pharmaceuticals. Specific examples of the other components include whitening agents other than component (D), moisturizers, antioxidants, oily components, UV absorbers, surfactants other than component (B), thickeners, alcohols other than component (A), powder components, colorants, aqueous components, solvents, sequestering agents, pharmaceuticals, sugars, synthetic emulsions, amino acids, organic amines, preservatives, chelating agents, various skin nutrients, etc. These may be used alone or in combination of two or more.

[0055] The content of other ingredients is not particularly limited as long as it does not impair the effect of the cosmetic composition according to one embodiment, and can be selected appropriately depending on the purpose.

[0056] <<Whitening Agents Other than Component (D)>> The whitening agent other than component (D) is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include arbutin, 4-methoxysalicylic acid, tranexamic acid, alkoxysalicylic acid, glutathione, ethyl vitamin C, L-ascorbic acid, magnesium ascorbyl phosphate, ascorbic acid glucoside, kojic acid, derivatives or salts thereof, etc. These may be used alone or in combination of two or more.

[0057] L-ascorbic acid, commonly known as vitamin C, has a strong reducing action that promotes cellular respiration, enzyme activation, and collagen formation, as well as melanin reduction. Examples of L-ascorbic acid derivatives include L-ascorbic acid monoesters such as L-ascorbic acid monophosphate and L-ascorbic acid 2-sulfate; L-ascorbic acid triesters such as L-ascorbic acid triphosphate; and L-ascorbic acid glucosides such as L-ascorbic acid 2-glucoside.

[0058] Examples of tranexamic acid derivatives include dimers of tranexamic acid such as trans-4-(trans-aminomethylcyclohexanecarbonyl)aminomethylcyclohexanecarboxylic acid hydrochloride; esters of tranexamic acid and hydroquinone such as 4-(trans-aminomethylcyclohexanecarboxylic acid 4'-hydroxyphenyl ester; esters of tranexamic acid and gentisic acid such as 2-(trans-4-aminomethylcyclohexylcarbonyloxy)-5-hydroxybenzoic acid; and amides of tranexamic acid such as trans-4-aminomethylcyclohexanecarboxylic acid methylamide, trans-4-(p-methoxybenzoyl)aminomethylcyclohexanecarboxylic acid, and trans-4-guanidinomethylcyclohexanecarboxylic acid.

[0059] Examples of alkoxysalicylic acids include salicylic acid in which the hydrogen atom at the 3-, 4-, or 5-position is substituted with an alkoxy group. The alkoxy group as the substituent is preferably any of a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group, and an isobutoxy group, and more preferably a methoxy group or an ethoxy group. Specific examples of alkoxysalicylic acids include 3-methoxysalicylic acid, 3-ethoxysalicylic acid, 4-methoxysalicylic acid, 4-ethoxysalicylic acid, 4-propoxysalicylic acid, 4-isopropoxysalicylic acid, 4-butoxysalicylic acid, 5-methoxysalicylic acid, 5-ethoxysalicylic acid, and 5-propoxysalicylic acid.

[0060] The salt of the drug is not particularly limited, and examples thereof include alkali metal salts or alkaline earth metal salts such as sodium salt, potassium salt, calcium salt, etc.; ammonium salt; amino acid salt; and the like.

[0061] <<Moisturizing Agent>> Examples of moisturizing agents include cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, urea, diglycerin ethylene oxide-propylene oxide adduct, chondroitin sulfate, and hyaluronic acid. Furthermore, alcohols other than component (A), which will be described later, can also be used as moisturizing agents. These may be used alone, or two or more may be used in combination.

[0062] <<Antioxidant>> Examples of antioxidants include ascorbic acid, α-tocopherol, carotenoids, etc. These may be used alone or in combination of two or more.

[0063] <<Oil-Based Component>> Examples of oil-based components include semi-solid oils, natural oils and fats, hydrocarbon-based oils and fats, synthetic oil components, silicones, etc. These may be used alone or in combination of two or more. Among these, it is preferable to contain semi-solid oil.

[0064] -Semi-solid oil- Examples of semi-solid oils include petrolatum, hydrogenated palm oil, palm kernel oil, macadamia nut oil phytosteryl, pentaerythritol tetra(behenate / benzoate / ethylhexanoate), etc. These may be used alone or in combination of two or more.

[0065] The content of the semi-solid oil in the cosmetic according to one embodiment is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 0.1% by mass to 5% by mass relative to the total mass of the cosmetic.

[0066] Furthermore, it is preferable to adjust the content of the semi-solid oil to be in the range of 1% by mass to 50% by mass relative to the total amount of liquid oil components blended in the cosmetic according to one embodiment.

[0067] -Natural Fats and Oils- Examples of natural fats and oils include camellia oil, macadamia nut oil, olive oil, castor oil, safflower oil, soybean oil, tea seed oil, cacao butter, coconut oil, hardened coconut oil, palm oil, Japan wax, hardened castor oil, beeswax, candelilla wax, carnauba wax, lanolin, liquid lanolin, jojoba wax, hard lanolin, polyoxyethylene lanolin alcohol ether, polyoxyethylene cholesterol ether, etc. These may be used alone or in combination of two or more.

[0068] - Hydrocarbon-based oils and fats - Examples of hydrocarbon-based oils and fats include liquid paraffin, ozokerite, squalene, paraffin, ceresin, petrolatum, microcrystalline wax, hydrogenated polydecene, etc. These may be used alone or in combination of two or more.

[0069] - Synthetic Oil Component - Examples of synthetic oil components include isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, pentaerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl-2-ethylhexanoate, castor oil fatty acid methyl ester, pentaerythrityl tetraethylhexanoate, etc. These may be used alone, or two or more may be used in combination.

[0070] -Silicones- Examples of silicones include chain polysiloxanes such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane, and methylhydrogenpolysiloxane; cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane, and tetramethyltetrahydrogenpolysiloxane; silicone resins capable of forming a three-dimensional network structure; and silicone rubber. These may be used alone or in combination of two or more.

[0071] In the cosmetic according to one embodiment, the content of the oily component is not particularly limited and can be selected appropriately depending on the purpose, but the content of the liquid oil is preferably 1% by mass to 30% by mass, and more preferably 5% by mass to 15% by mass, relative to the total mass of the cosmetic.

[0072] <<Ultraviolet Absorber>> Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, and N,N-dimethylpara-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; amyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate. salicylic acid-based ultraviolet absorbers such as octyl cinnamate, ethyl 4-isopropyl cinnamate, methyl 2,5-diisopropyl cinnamate, ethyl 2,4-diisopropyl cinnamate, propyl p-methoxycinnamate, isoamyl p-methoxycinnamate, octyl p-methoxycinnamate (2-ethylhexyl p-methoxycinnamate), 2-ethoxyethyl p-methoxycinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate, and glyceryl Cinnamic acid-based ultraviolet absorbers such as mono-2-ethylhexanoyl-di-p-methoxycinnamate; benzophenone-based ultraviolet absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, and 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate; Examples of ultraviolet absorbers include 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor, urocanic acid, urocanic acid ethyl ester, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one, etc. These may be used alone or in combination of two or more.

[0073] <<Surfactants Other Than Component (B)>> Examples of surfactants other than component (B) include lipophilic nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, etc. These may be used alone or in combination of two or more.

[0074] Lipophilic Nonionic Surfactants Examples of lipophilic nonionic surfactants include sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, and diglycerol sorbitan penta-2-ethylhexylate; glycerin or polyglycerin esters such as glycerin monostearate, glycerin α,α'-oleic acid pyroglutamate, and glycerin monostearate malate; propylene glycol fatty acid esters such as propylene glycol monostearate; and hydrogenated castor oil derivatives.

[0075] - Anionic Surfactant - Examples of anionic surfactants include fatty acid soaps such as sodium laurate and sodium palmitate; higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfates such as polyoxyethylene triethanolamine lauryl sulfate and sodium polyoxyethylene lauryl sulfate; N-acyl sarcosinates such as sodium lauroyl sarcosinate; higher fatty acid amide sulfonates such as sodium N-myristoyl-N-methyl taurate, sodium coconut oil fatty acid methyl tauride, and sodium lauryl methyl tauride; phosphate salts such as sodium polyoxyethylene oleyl ether phosphate and sodium polyoxyethylene stearyl ether phosphate; sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauroyl methyl tauride ... alkylbenzenesulfonates such as sodium linear dodecylbenzenesulfonate and triethanolamine linear dodecylbenzenesulfonate; N-acylglutamates such as monosodium N-lauroylglutamate and disodium N-stearoylglutamate; higher fatty acid ester sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; polyoxyethylene alkyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfates; sodium lauroylmonoethanolamide succinate; N-palmitoylaspartic acid; ditriethanolamine; coconut oil fatty acid collagen hydrolyzed alkali salt; and stearoylmethyl taurine salt.

[0076] -Cationic Surfactants- Examples of cationic surfactants include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; dialkyldimethylammonium salts such as distearyldimethylammonium chloride; alkylpyridinium salts such as poly(N,N'-dimethyl-3,5-methylenepiperidinium chloride) and cetylpyridinium chloride; alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyoxyethylene alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride; cationic polymers; and β-N-N-dimethyl-N-ethylammonioethyl acrylate vinylpyrrolidone chloride copolymers.

[0077] —Amphoteric Surfactant— Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants such as 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt; and betaine-based amphoteric surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amido betaine, and sulfobetaine.

[0078] <<Thickeners>> Examples of thickeners include gum arabic, carrageenan, tragacanth gum, quince seed (marmelo), casein, sodium caseinate, dextrin, gelatin, sodium alginate, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer (carbomer), guar gum, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, etc. These may be used alone or in combination of two or more.

[0079] <<Alcohols Other than Component (A)>> Examples of alcohols other than component (A) include polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, erythritol, trimethylolpropane, pentaerythritol, sorbitol, maltitol, diglycerin, and polyethylene glycol.

[0080] <<Powder Component>> The powder component may be an inorganic powder component or an organic powder component. These may be used alone or in combination of two or more.

[0081] Examples of inorganic powder components include mica, talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, lepidolite, biotite, lithia mica, synthetic mica, anhydrous silicic acid (silica), magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, silica, calcined calcium sulfate (calcined gypsum), aluminum oxide, barium sulfate, zeolite, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, titanium oxide, zinc oxide, metal soaps (zinc myristate, calcium palmitate, aluminum stearate, etc.), and boron nitride.

[0082] Examples of organic powders include polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, calcium carbonate powder, magnesium carbonate powder, styrene-acrylic acid copolymer resin powder, polymethylsilsesquioxane powder, and cellulose powder.

[0083] <<Coloring Material>> Examples of the coloring material include pigments and dyes.

[0084] Pigments Examples of pigments include inorganic pigments, organic pigments, pearl pigments, and metal powder pigments.

[0085] Examples of inorganic pigments include titanium dioxide, zinc oxide, iron oxide (red iron oxide), iron titanate, yellow iron oxide, black iron oxide, carbon black, low-order titanium oxide, mango violet, cobalt violet, chromium oxide, ultramarine, and iron blue.

[0086] Examples of organic pigments include Red No. 3, Red No. 104, Red No. 106, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 227, Red No. 228, Red No. 230, Red No. 401, Red No. 405, Red No. 505, Orange No. 203, Orange No. 204, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Yellow No. 205, Yellow No. 401, Blue No. 1, Blue No. 404, Green No. 3, and zirconium lake, barium lake, or aluminum lake versions of these pigments.

[0087] Examples of pearl pigments include titanium oxide coated mica, colored titanium oxide coated mica, titanium oxide coated bismuth oxychloride, bismuth oxychloride, and fish scale foil.

[0088] Examples of metal powder pigments include aluminum powder and copper powder.

[0089] - Pigments - Examples of pigments include natural pigments such as chlorophyll and β-carotene.

[0090] <<Solvent>> Examples of the solvent include water and lower alcohols. Examples of the lower alcohol include alcohols having 5 or fewer carbon atoms. Specific examples of the lower alcohol include methanol, ethanol, propyl alcohol, isopropyl alcohol, 2-amino-2-methyl-1-propanol, and 2-amino-2-methyl-1,3-propanediol.

[0091] <<Sequestering Agent>> Examples of sequestering agents include disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, and gluconic acid.

[0092] <<Drugs>> Examples of drugs include caffeine, tannin, verapamil, licorice extract, glabridin, hot water extract of fire thorn fruit, various herbal medicines, tocopherol acetate, glycyrrhizic acid, derivatives thereof, and salts thereof.

[0093] <<Sugars>> Examples of sugars include glucose, fructose, mannose, sucrose, and trehalose.

[0094] <<Synthetic Resin Emulsion>> Examples of synthetic resin emulsions include acrylic resin emulsions and polyvinyl acetate resin emulsions.

[0095] <<Amino Acids>> Examples of amino acids include glycine, leucine, phenylalanine, tyrosine, aspartic acid, glutamic acid, sodium glutamate, arginine, histidine, lysine, cystine, cysteine, sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, glutathione, and pyrrolidone carboxylic acid.

[0096] <<Organic Amines>> Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0097] <<Preservatives>> Examples of preservatives include benzoic acid, salicylic acid, paraoxybenzoic acid esters (methylparaben, ethylparaben, butylparaben, etc.), sorbic acid, parachlormetacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizers, and phenoxyethanol.

[0098] <<Chelating Agents>> Examples of chelating agents include citramalic acid, agaric acid, glyceric acid, shikimic acid, hinokitiol, gallic acid, tannic acid, caffeic acid, ethylenediamine-N,N,N',N'-tetraacetic acid trisodium salt dihydrate (EDTA-2Na.2H ２O), ethylene glycol diamine tetraacetic acid, diethylene triamine pentaacetic acid, phytic acid, polyphosphoric acid, metaphosphoric acid, analogs thereof, alkali metal salts thereof, carboxylic acid esters thereof, and the like.

[0099] <Dosage Form> The dosage form of the cosmetic according to one embodiment is not particularly limited and can be appropriately selected depending on the purpose, but is preferably a liquid cosmetic, more preferably a liquid emulsion cosmetic, and even more preferably an oil-in-water emulsion cosmetic.

[0100] The product form of the cosmetic according to one embodiment is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include cosmetics for skin care such as lotion, cream, emulsion, and serum; makeup cosmetics such as foundation and makeup base; sunscreen cosmetics; tanning cosmetics; skin cleansing cosmetics such as face wash and makeup remover; ointments, etc. The product form of the cosmetic according to one embodiment may also be a form in which the cosmetic is impregnated into a base material such as a pack. Among these, the product form of the cosmetic according to one embodiment is preferably used as an emulsion, as this is non-sticky and has excellent compatibility with the skin and a moist feeling.

[0101] <Production Method> The cosmetic preparation according to one embodiment may be produced according to any method typically used for liquid cosmetic preparations, more preferably oil-in-water emulsion cosmetic preparations. For example, an example method involves dissolving an aqueous component by heating and mixing uniformly, then adding an oil component that has also been dissolved by heating and mixed uniformly, and mixing and emulsifying the mixture.

[0102] The heating temperature for the aqueous phase component and the oil phase component is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 70°C to 80°C.

[0103] The emulsification method is not particularly limited, and known methods can be used, including, for example, mechanical emulsification using a high-pressure emulsifier such as a high-pressure homogenizer, a high-shear disperser, a colloid mill, etc., phase inversion emulsification, aggregation method, liquid crystal emulsification, D-phase emulsification, etc. These methods can be used alone or in combination.

[0104] A specific example of a method for producing a cosmetic according to one embodiment includes first dissolving components (A) and (D), and optionally other water-soluble components selected from among the other components, in water to prepare an aqueous phase. Next, components (B) and (C), and optionally other water-insoluble components selected from among the other components, are mixed to prepare an oil phase. Finally, the oil phase is added to the aqueous phase, followed by stirring to produce a cosmetic according to one embodiment.

[0105] The following examples and comparative examples will explain the embodiments in more detail, but the embodiments are not limited to these examples and comparative examples. In the examples and comparative examples, the content of each component shown in Tables 1 and 2 below is expressed as "% by mass" relative to the total mass of the oil-in-water emulsion cosmetic, unless otherwise specified, and all values ​​are converted into pure contents.

[0106] (Examples 1 to 3 and Comparative Examples 1 to 5) Oil-in-water emulsion cosmetics (milks) were prepared by a conventional method, with the compositions and contents (mass%) shown in Tables 1 and 2 below. Note that, since component (D) can also be used as a whitening agent, in Comparative Example 5, "ascorbic acid-2-glycoside" was used as a comparative component to component (D).

[0107] <Evaluation> The oil-in-water emulsion cosmetics prepared in Examples 1 to 3 and Comparative Examples 1 to 5 were evaluated for "non-stickiness," "good compatibility," and "moist feeling" using the following methods. The evaluation results are shown in Tables 1 and 2 below.

[0108] <<Evaluation of Non-stickiness>> The non-stickiness of each of the oil-in-water emulsion cosmetics of Examples 1 to 3 and Comparative Examples 1 to 5 was evaluated using the following method. Five expert evaluators checked the non-stickiness of the skin when applying each of the oil-in-water emulsion cosmetics of Examples 1 to 3 and Comparative Examples 1 to 5 to the skin, and evaluated it based on the following evaluation criteria. [Evaluation criteria for non-stickiness] A (very good): 5 out of 5 people answered that it was not sticky B (good): 4 out of 5 people answered that it was not sticky C (fairly good): 3 out of 5 people answered that it was not sticky D (poor): 2 or more out of 5 people answered that it was not sticky

[0109] <<Evaluation of Compatibility>> The compatibility of each of the oil-in-water emulsion cosmetics of Examples 1 to 3 and Comparative Examples 1 to 5 was evaluated using the following method. Five expert evaluators checked the compatibility of each of the oil-in-water emulsion cosmetics of Examples 1 to 3 and Comparative Examples 1 to 5 to the skin when they were applied, and evaluated them based on the following evaluation criteria. [Evaluation criteria for compatibility] A (very good): 5 out of 5 people answered that the compatibility was good B (good): 4 out of 5 people answered that the compatibility was good C (fairly good): 3 out of 5 people answered that the compatibility was good D (poor): 2 or more out of 5 people answered that the compatibility was good

[0110] <<Evaluation of Moisture Feeling>> The moistness of each of the oil-in-water emulsion cosmetics of Examples 1 to 3 and Comparative Examples 1 to 5 was evaluated using the following method. Five expert evaluators checked the moistness of each of the oil-in-water emulsion cosmetics of Examples 1 to 3 and Comparative Examples 1 to 5 when they were applied to the skin, and evaluated them based on the following evaluation criteria. [Evaluation criteria for moistness feeling] A (very good): 5 out of 5 people answered that there was a moist feeling B (good): 4 out of 5 people answered that there was a moist feeling C (fairly good): 3 out of 5 people answered that there was a moist feeling D (poor): 2 or more out of 5 people answered that there was a moist feeling

[0111]

[0112]

[0113] The components used in the examples and comparative examples are as follows:

[0114] Carboxyvinyl polymer: trade name "Carbopol (registered trademark) 981" (manufactured by Lubrizol) Polyoxyethylene (20) behenyl ether: trade name "NIKKOL BB-20" (manufactured by Nikko Chemicals Co., Ltd.) Pentaerythrityl tetraethylhexanoate: trade name "RA-PE-408" (manufactured by Nippon Fine Chemical Co., Ltd.) Dimethicone: trade name "Silicone KF-96A-6T" (manufactured by Shin-Etsu Silicones Co., Ltd.) 2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine hydrochloride: a compound represented by the following structural formula (1), produced by the method described in Japanese Patent No. 4586108.

[0115]

[0116] The present invention provides, for example, the following embodiments: <1> (A) a higher alcohol having 14 to 22 carbon atoms, (B) a hydrophilic polyoxyethylene alkyl ether, (C) a glycerin monoalkyl ether, and (D) a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof,

[0117] (In the general formula (1), R １ , R ３ , R ４ , and R ６ each independently represents an alkyl group having 1 to 3 carbon atoms; R ２ and R ５ each independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms. <2> The cosmetic is characterized by containing (D) the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof, ２ and R ５ <3> The cosmetic according to <1>, wherein R in the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof (D) is a hydrogen atom. １ , R ３ , R ４ , and R ６is a methyl group. <4> The cosmetic according to any one of <1> to <3>, wherein the content of (D) the pyrimidylpyrazole compound represented by general formula (1) or a pharmacologically acceptable salt thereof is 0.1% by mass to 1% by mass. <5> The cosmetic according to any one of <1> to <4>, wherein the (A) higher alcohol having 14 to 22 carbon atoms has a linear saturated alkyl chain. <6> The cosmetic according to any one of <1> to <5>, wherein the alkyl chain of the (B) hydrophilic polyoxyethylene alkyl ether is a linear saturated alkyl chain. <7> The cosmetic according to any one of <1> to <6>, wherein the average number of moles of ethylene oxide added to the polyoxyethylene chain of the (B) hydrophilic polyoxyethylene alkyl ether is 10 to 30. <8> The cosmetic according to any one of <1> to <7>, wherein the alkyl chain of the (C) glycerin monoalkyl ether is a linear saturated alkyl chain. <9> The cosmetic according to any one of <1> to <8>, wherein the (C) glycerin monoalkyl ether is glycerin monostearyl ether. <10> The cosmetic according to any one of <1> to <9>, wherein the mass ratio [(D) / (A+B+C)] of the total content of (D) the pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof to the total content of the (A) higher alcohol having 14 to 22 carbon atoms, the (B) hydrophilic polyoxyethylene alkyl ether, and the (C) glycerin monoalkyl ether is 0.1 to 3:

[0118] As described above, the present invention has been described based on specific embodiments and examples, but these embodiments and examples are presented merely as examples, and the present invention is not limited to the above embodiments and examples. The above embodiments can be embodied in various other forms, and various combinations, omissions, substitutions, additions, modifications, etc. can be made without departing from the spirit of the invention. These embodiments and their modifications are included in the scope and spirit of the invention, and are also included in the inventions described in the claims and their equivalents.

[0119] This international application claims priority based on Japanese Patent Application No. 2023-217297, filed on December 22, 2023, the entire contents of which are incorporated herein by reference.

Claims

1. (A) a higher alcohol having 14 to 22 carbon atoms; (B) a hydrophilic polyoxyethylene alkyl ether; (C) a glycerin monoalkyl ether; and (D) a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof. (In the general formula (1), R １ , R ３ , R ４ , and R ６ each independently represents an alkyl group having 1 to 3 carbon atoms; R ２ and R ５ each independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.

2. (D) R in the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof ２ and R ５ The cosmetic preparation according to claim 1 , wherein is a hydrogen atom.

3. (D) R in the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof １ , R ３ , R ４ , and R ６ The cosmetic preparation according to claim 1 or 2, wherein is a methyl group.

4. The cosmetic preparation according to claim 1, wherein the content of (D) the pyrimidylpyrazole compound represented by general formula (1) or a pharmacologically acceptable salt thereof is 0.1% by mass to 1% by mass.

5. The cosmetic preparation according to claim 1, wherein the (A) higher alcohol having 14 to 22 carbon atoms has a linear saturated alkyl chain.

6. The cosmetic according to claim 1, wherein the alkyl chain of the hydrophilic polyoxyethylene alkyl ether (B) is a linear, saturated alkyl chain.

7. The cosmetic preparation according to claim 1, wherein the average number of moles of ethylene oxide added to the polyoxyethylene chain of the hydrophilic polyoxyethylene alkyl ether (B) is 10 to 30.

8. The cosmetic preparation according to claim 1, wherein the alkyl chain of the glycerin monoalkyl ether (C) is a linear, saturated alkyl chain.

9. The cosmetic preparation according to claim 1, wherein the (C) glycerin monoalkyl ether is glycerin monostearyl ether.

10. The cosmetic preparation according to claim 1, wherein the mass ratio [(D) / (A+B+C)] of the total content of (D) a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof to the total content of (A) a higher alcohol having 14 to 22 carbon atoms, (B) a hydrophilic polyoxyethylene alkyl ether, and (C) a glycerin monoalkyl ether is 0.1 to 3:

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