Odor binding protein compositions and methods of making and using the same

Abstract

Provided herein are compositions comprising an odor binding protein for non-aerosol formulations intended, to maintain hair and / or skin health of an individual and prolong time between application of such compositions. In some embodiments, the compositions may remove malodors. Also, provided herein are methods of making and using compositions described herein for non-aerosol formulations for maintaining hair and / or skin health.

Description

WSGR Docket No.63230-728.601 ODOR BINDING PROTEIN COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME CROSS REFERENCE

[0001] This application claims the benefit of U.S. Provisional Application Serial No. 63 / 612,211, filed December 19, 2023, and U.S. Provisional Application Serial No.63 / 667,522 filed on July 3, 2024, each of which is incorporated herein by reference in its entirety. SEQUENCE LISTING

[0002] The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled 63230-728_601_SL.xml, created December 16, 2024, which is 305 kilobytes in size. The information in the electronic format of the Sequence Listing is incorporated by reference in its entirety. BACKGROUND

[0003] Overuse of water and use of volatile organic chemicals for the preparation of personal care products is wasteful and environmentally unsafe. SUMMARY

[0004] High frequency use of in-shower shampoos by an individual to mitigate scalp malodor and oiliness can expose hair fibers to harmful and damaging agents in tap water (e.g., from a shower or faucet) including but not limited to alkaline pH of tap water, hard water, and trace metals and minerals. In certain instances, repeated use of in-shower shampoos can lead to color loss in treated hair. Furthermore, commercially available alternatives to in-shower shampoos, such as styling agents or dry shampoos, are often provided to the hair and / or scalp by aerosol delivery which requires high levels of toxic and environmentally unsafe organic chemicals to be effective and may require special shipping due to pressurization and high flammability. Moreover, in order to formulate aerosol- delivered products (e.g., with propellants) as well as the need for a drier application feel further necessitates inclusion of low levels of water, making incorporation of water-soluble extracts that possess scalp skin benefits challenging. Aerosol-delivered product formulations introduce additional challenges, such as difficulty in controlling product pH upon application. Inclusion of higher levels of powder in aerosol-delivered products aids in oil absorption and odor adsorption, but excess levels can be over-drying to scalp skin without hydrating ingredients causing an itchy or uncomfortable scalp. Incorporation of high levels of fragrance to mask odors can also contribute to scalp irritation.WSGR Docket No.63230-728.601

[0005] In one aspect, provided herein are compositions and formulations for application to an individual (e.g., to mitigate scalp malodor and oiliness) that reduce / and or eliminate use of dangerous and environmentally harmful ingredients and damaging agents like organic solvents.

[0006] The above features and methods are of representative embodiments only and are not intended to limit the scope and breadth of the claims.

[0007] In some aspects, provided herein is a composition comprising an odor binding protein comprising a sequence at least about 80% identical to any one of SEQ ID NOS: 1-82, 201-340 and an absorbing agent. In some embodiments, the absorbing agent binds to and / or absorbs oil and sebum. In some embodiments, the absorbing agent comprises a compound comprising silicon. In some embodiments, the compound comprises silica, a silicate salt, silica silylate, silica dimethyl silylate, silica dimethicone silylate, or a combination of two or more thereof. In some embodiments, the absorbing agent comprises silica. In some embodiments, the absorbing agent comprises a carbonate salt, metal oxide, clay mineral powder, or a combination of two or more thereof. In some embodiments, the absorbing agent is from about 0.01% to about 40% by weight (w / w) of the composition. In some embodiments, the absorbing agent is from about 1% to about 25% by weight (w / w) of the composition. In some embodiments, the absorbing agent is from about 2% to about 15% by weight (w / w) of the composition. In some embodiments, the absorbing agent comprises silica from about 2% to about 15% by weight (w / w) of the composition. In some embodiments, the composition further comprises a sebum regulating agent. In some embodiments, when applied to hair, the composition maintains or increases a hair property as compared to the hair property of hair not applied with the composition, where the hair property comprises hair strength, hair color, hair elasticity, hair luster, hair porosity, or a combination thereof. In some instances, the hair elasticity is determined by measuring a Young’s Modulus of hair. In some instances, the hair color is determined by a color fade assay. In some instances, the hair strength is determined by a break stress. In some instances, the hair luster is determined by polarized spectroscopy, imaging, or both. In some instances, the hair porosity is determined by measuring a density of hair. In some embodiments, the composition is applied to hair prior to heat application.

[0008] In some aspects, provided herein is a composition comprising an odor binding protein comprising a sequence at least about 80% identical to any one of SEQ ID NOS: 1-82, 201-340; and a sebum regulating agent. In some embodiments, the sebum regulating agent comprises bioactive compounds for reducing sebum and oil. In some embodiments, the sebum regulating agent reduces, regulates, or removes sebum and / or sweat. In some embodiments, the sebum regulating agent comprises salicylic acid, microalgae extracts, green tea emulsions, avocado extract, Opuntia ficus- indica stem extract, Anetholea anisate leaf extract, Tetraselmis Suecica extract, Alteromonas ferment extract, Pseudoalteromonas ferment extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Saccharum officinarum (sugarcane) extract, Rhodomyrtus tomentosa fruit extract,WSGR Docket No.63230-728.601 Hedychium coronarium root extract, Epilobium angustifolium flower / leaf / stem extract, Tremella fuciformis sporocarp extract, or a combination of two or more thereof. In some embodiments, the sebum regulating agent comprises tetraselmis suecica extract. In some embodiments, the sebum regulating agent is from about 0.0001% to about 1% by weight (w / w) of the composition. In some embodiments, the sebum regulating agent is from about 0.0005% to about 0.5% by weight (w / w) of the composition. In some embodiments, the sebum regulating agent is from about 0.001% to about 0.05% by weight (w / w) of the composition. In some embodiments, the sebum regulating agent comprises tetraselmis suecica extract from about 0.001% to about 0.05% by weight (w / w) of the composition.

[0009] In some embodiments, the composition has a pH from about 6 to about 9. In some embodiments, the composition has a pH from about 7 to about 7.5.

[0010] In some embodiments, the composition further comprises a buffering agent. In some embodiments, the buffering agent maintains the pH of the composition. In some embodiments, the buffering agent comprises a weak acid, weak base, amino acid, weak organic acid, weak organic base, or combinations of two or more thereof. In some embodiments, the buffering agent comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, arginine, tromethamine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. In some embodiments, the buffering agent comprises lactic acid, citric acid, tromethamine (Tris), and arginine.

[0011] In some embodiments, buffering agent is from about 0.001% to about 1% by weight (w / w) of the composition. In some embodiments, the buffering agent is from about 0.005% to about 0.5 by weight (w / w) of the composition. In some embodiments, the buffering agent is from about 0.01% to about 0.1% by weight (w / w) of the composition. In some embodiments, the buffering agent comprises lactic acid from about 0.0005% to about 0.01% by weight (w / w), citric acid from about 0.01% to about 0.1% (w / w), tromethamine from about 0.001% to about 0.05% (w / w), and arginine from about 0.000075% to about 0.005% (w / w) of the composition.

[0012] In some embodiments, the sequence is at least about 90% identical to any one of SEQ ID NOS: 1-82, 201-340. In some embodiments, the odor binding protein binds to an odorant molecule.

[0013] In some embodiments, the odor binding protein is from about 0.001% to about 1% by weight (w / w) of the composition. In some embodiments, the odor binding protein is from about 0.0025% to about 0.5% by weight (w / w) of the composition. In some embodiments, the odor binding protein is from about 0.005% to about 0.1% by weight (w / w) of the composition.

[0014] In some embodiments, the composition further comprises a solvent. In some embodiments, the solvent comprises a polar solvent, nonpolar solvent, water, alcohol, polyol, glycol, sugar, polyethylene glycol, or a combination of two or more thereof. In some embodiments, the solvent comprises water, mannitol, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, denatured ethanol, denatured methanol,WSGR Docket No.63230-728.601 denatured propanol, denatured isopropyl alcohol, denatured butanol, denatured pentanol, denatured hexanol, methanol, ethanol, propanol, isopropyl alcohol, butanol, pentanol, hexanol, glycerin, butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols, sorbitol, glucose, fructose, maltose, lactose, sucrose, PEG-4, PEG-6, PEG-8, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, or a combination of two or more thereof. In some embodiments, the solvent comprises water, mannitol, glycerin, and denatured ethanol. In some embodiments, the solvent comprises water and denatured ethanol.

[0015] In some embodiments, the solvent is from about 35% to about 99% by weight (w / w) of the composition. In some embodiments, the solvent is from about 60% to about 97% by weight (w / w) of the composition. In some embodiments, solvent is from about 80% to about 95% by weight (w / w) of the composition. In some embodiments, the solvent comprises water from about 45% to about 85% by weight (w / w), mannitol from about 0.02% to about 0.1% (w / w), glycerin from about 0.1% to about 1% (w / w), and denatured ethanol from about 10% to about 30% (w / w) of the composition. In some embodiments, the solvent comprises water from about 45% to about 85% by weight (w / w) and denatured ethanol from about 10% to about 30% (w / w) of the composition.

[0016] In some embodiments, the composition further comprises a humectant. In some embodiments, the humectant comprises a hyaluronate, glycol, sorbitol, sugar, carbocyclic sugar, alcohol, or a combination of two or more thereof. In some embodiments, the humectant comprises 1,2,6 hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyldiol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, hydrolyzed hyaluronic acid, sodium hyaluronate, inositol, erythritol, capryl glycol, acetamidoethoxyethanol, or a combination of two or more thereof. In some embodiments, the humectant comprises glycerin, mannitol, sodium hyaluronate, and hydrolyzed hyaluronic acid.

[0017] In some embodiments, the humectant is from about 0.01% to about 5% by weight (w / w) of the composition. In some embodiments, the humectant is from about from about 0.1% to about 2% by weight (w / w) of the composition. In some embodiments, the humectant is from about 0.25% to about 1% by weight (w / w) of the composition. In some embodiments, the humectant comprises mannitol from about 0.02% to about 0.1% by weight (w / w), glycerin from about 0.1% to about 1% (w / w), sodium hyaluronate from about 0.001% to about 0.01% (w / w), and hydrolyzed hyaluronic acid from about 0.001% to about 0.1% (w / w) of the composition.

[0018] In some embodiments, the composition further comprises a rheology modifying agent. In some embodiments, the rheology modifying agent comprises a hydrocolloid, naturally derived polymer, aqueous natural polymer, sugars, or a combinations of two or more thereof. In some embodiments, the rheology modifying agent comprises pectin, gellan gum, carrageen, glycerin, agar,WSGR Docket No.63230-728.601 xanthan gum, pullulan, algin, tetragonoloba (guar) gum, sclerotium gum, acacia Senegal gum, cellulose, cellulose gum, carboxymethylcellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, lauryl polyglucose, or a combination of two or more thereof. In some embodiments, the rheology modifying agent comprises gellan gum.

[0019] In some embodiments, the rheology modifying agent is from about 0.005% to about 10% by weight (w / w) of the composition. In some embodiments, the rheology modifying agent is from about 0.01% to about 2% by weight (w / w) of the composition. In some embodiments, the rheology modifying agent is from about 0.05% to about 0.5% by weight (w / w) of the composition. In some embodiments, the rheology modifying agent comprises gellan gum from about 0.05% to about 0.5% by (w / w) of the composition.

[0020] In some embodiments, the composition further comprises a stabilizing agent. In some embodiments, the stabilizing agent comprises a salt, sulfate, or a combination of two or more thereof. In some embodiments, the stabilizing agent comprises calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, or a combination of two or more thereof. In some embodiments, the stabilizing agent comprises sodium chloride.

[0021] In some embodiments, the stabilizing agent is from about 0.005% to about 10% by weight (w / w) of the composition. In some embodiments, the stabilizing agent is from about 0.01% to about 2% by weight (w / w) of the composition. In some embodiments, the stabilizing agent is from about 0.05% to about 0.5% by weight (w / w) of the composition. In some embodiments, the stabilizing agent comprises sodium chloride from about 0.05% to about 0.5% by weight (w / w) of the composition.

[0022] In some embodiments, the composition further comprises a chelating agent. In some embodiments, the chelating agent comprises EDTA, sodium phytate, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, caprylhydroxamic acid, or a combination of two or more thereof. In some embodiments, the chelating agent comprises sodium phytate. In some embodiments, the chelating agent is from about 0.005% to about 10% by weight (w / w) of the composition. In some embodiments, the chelating agent is from about 0.01% to about 2% by weight (w / w) of the composition. In some embodiments, the chelating agent is from about 0.05% to about 0.5% by weight (w / w) of the composition. In some embodiments, the chelating comprises sodium phytate from about 0.05% to about 0.5% by weight (w / w) of the composition.

[0023] In some embodiments, the composition further comprises a preservative. In some embodiments, the preservative comprises an alcohol, paraben, formaldehyde release, carbamate, sorbate, or a combination of two or more thereof. In some embodiments, the preservative comprisesWSGR Docket No.63230-728.601 benzyl alcohol, benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or a combination of two or more thereof.

[0024] In some embodiments, the preservative comprises benzyl alcohol. In some embodiments, the preservative is from about 0.005% to about 10% by weight (w / w) of the composition. In some embodiments, the preservative is from about 0.01% to about 5% by weight (w / w) of the composition. In some embodiments, the preservative is from about 0.5% to about 2% by weight (w / w) of the composition. In some embodiments, the preservative comprises benzyl alcohol from about 0.5% to about 2% by weight (w / w) of the composition.

[0025] In some embodiments, the composition is a suspension. In some embodiments, the suspension comprises a non-aerosol hydroalcoholic formulation. In some embodiments, the composition is a hair or scalp composition. In some embodiments, when applied to the hair, the composition maintains or increases the hair property as compared to the hair property of hair not applied with the composition. In some embodiments, the composition is applied to the hair prior to heat application.

[0026] In some aspects, provided herein is a method for reducing malodor of a hair and / or scalp of an individual, the method comprising administering an effective amount of the composition as described herein to the hair and / or scalp of the individual.

[0027] In some embodiments, provided herein is a method for reducing sebum in a hair and / or scalp of an individual, the method comprising administering an effective amount of the composition as described herein to the hair and / or scalp of the individual.

[0028] In some embodiments, provided herein is a method for reducing sebum on a hair and / or scalp of an individual, the method comprising administering an effective amount of a composition comprising an odor binding protein to the hair and scalp of the individual, wherein the odor binding protein comprises a sequence at least about 80% identical to any one of SEQ ID NOS: 1-82, 201- 340.

[0029] In some embodiments, the composition further comprises an absorbing agent.

[0030] In some embodiments, the composition further comprises a sebum reducing agent.

[0031] In some embodiments, skin surface levels of sebum are reduced compared to a baseline measurement for about 24 to about 72 hours or more after administration of the composition. In some embodiments, sebum reduction is measured by a Sebumeter. In some embodiments, when measured immediately after administration compared to a baseline measurement, sebum is reduced about 1 to about 20 g / cm2. In some embodiments, when measured immediately after administration compared to a baseline measurement, sebum is reduced about 5 to about 15 g / cm2.WSGR Docket No.63230-728.601 In some embodiments, when measured immediately after administration compared to a baseline measurement, sebum is reduced by about 10 g / cm2. In some embodiments, when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 19 g / cm2. In some embodiments, when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced about 4 to about 14 g / cm2. In some embodiments, when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced by about 9 g / cm2. In some embodiments, when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 17 g / cm2. In some embodiments, when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced about 3 to about 12 g / cm2. In some embodiments, when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced by about 7 g / cm2. In some embodiments, when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 15 g / cm2. In some embodiments, when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced about 2 to about 10 g / cm2. In some embodiments, when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced by about 5.5 g / cm2. In some embodiments, when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 8 g / cm2. In some embodiments, when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced about 2 to about 6 g / cm2. In some embodiments, when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced by about 4 g / cm2.

[0032] In some aspects, provided herein is a method for reducing malodor on a hair and / or scalp of an individual, the method comprising administering an effective amount of a composition comprising an odor binding protein to the hair and scalp of the individual, wherein the odor binding protein comprises a sequence at least about 80% identical to any one of SEQ ID NOS: 1-82, 201- 340. In some embodiments, the composition further comprises an absorbing agent. In some embodiments, the composition further comprises a sebum reducing agent. In some embodiments, malodor levels are reduced compared to a baseline measurement for about 24 to about 72 hours or more after administration of the composition. In some embodiments, malodor levels are evaluated by a trained odor grader on a scale of 0 to 10. In some embodiments, when measured immediately after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 7 on the scale. In some embodiments, when measured immediately after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 6 on the scale. In some embodiments, when measured immediately after administration compared to a baseline measurement, malodor levels are reduced by about 5 on the scale. In some embodiments, when measured about 12 hours after administration compared to a baseline measurement, malodor levelsWSGR Docket No.63230-728.601 are reduced about 2 to about 7 on the scale. In some embodiments, when measured about 12 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 6 on the scale. In some embodiments, when measured about 12 hours after administration compared to a baseline measurement, malodor levels are reduced by about 5 on the scale. In some embodiments, when measured about 24 hours after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 6 on the scale. In some embodiments, when measured about 24 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 5 on the scale. In some embodiments, when measured about 24 hours after administration compared to a baseline measurement, malodor levels are reduced by about 4 on the scale. In some embodiments, when measured about 48 hours after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 5 on the scale. In some embodiments, when measured about 48 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 4 on the scale. In some embodiments, when measured about 48 hours after administration compared to a baseline measurement, malodor levels are reduced by about 3.5 on the scale. In some embodiments, when measured about 72 hours after administration compared to a baseline measurement, malodor levels are reduced about 1 to about 4 on the scale. In some embodiments, when measured about 72 hours after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 3 on the scale. In some embodiments, when measured about 72 hours after administration compared to a baseline measurement, malodor levels are reduced by about 2.5 on the scale.

[0033] In some embodiments, when applied to the hair, the composition maintains or increases a hair property as compared to the hair property of hair not applied with the composition. In some embodiments, the composition described herein is applied to the hair prior to heat application. DETAILED DESCRIPTION

[0034] Provided herein are compositions (e.g., for application to the hair and / or skin of individuals), as well as methods of making and using such compositions. In certain embodiments, any composition provided herein can comprise formulations (e.g., non-aerosol, hydroalcoholic formulations) for application to the hair and / or skin of individuals. In specific embodiments, compositions provided herein comprise non-aerosol, hydroalcoholic formulations. In some instances, compositions provided herein are useful in prolonging time between washing the hair of an individual without comprising scalp comfort and maintaining scalp health. In certain instances, such compositions are useful in addressing such aspects while meeting volatile organic compound (VOC) reduction requirements.

[0035] In some embodiments, provided herein are compositions (e.g., provided to the hair and / or scalp of an individual) comprising an odor binding protein (e.g., such as a peptide comprisingWSGR Docket No.63230-728.601 a sequence at least about 80% identical to any one of SEQ ID NOS: 1-82, 201-340). In certain embodiments, provided herein are compositions comprising an odor binding protein and an absorbing agent. In some embodiments, provided herein are compositions comprising an odor binding protein and a sebum regulating agent.

[0036] In some embodiments, provided herein are compositions (e.g., provided to the hair and / or scalp of an individual) comprising an odor binding protein (e.g., such as a peptide comprising a sequence at least about 80% identical to any one of SEQ ID NOS: 1-82, 201-340). In certain embodiments, provided herein are compositions comprising an odor binding protein and an absorbing agent. In some embodiments, the composition maintains or increases a hair property where applied, e.g., hair and / or skin of individuals, relative to hair or and / or skin not applied with the composition described herein. In some embodiments, the composition maintains a hair property where applied, e.g., hair and / or skin of individuals, relative to hair or and / or skin not applied with the composition described herein. In some embodiments, the composition increases a hair property where applied, e.g., hair and / or skin of individuals, relative to hair or and / or skin not applied with the composition described herein. In some embodiments, the composition is applied to the hair prior to heat application. In some embodiments, the hair property of hair applied with the composition is greater than a hair property of hair not applied with the composition.

[0037] As used herein, in some instances, hair property refers to various aspects of hair characteristics, e.g., hair strength, hair color, hair elasticity, hair luster, hair porosity, or a combination thereof. In some instances, the hair property comprises hair strength, hair color, hair elasticity, hair luster, hair porosity, or a combination thereof. In some instances, the hair property can be determined using appropriate tests or measurements. In some instances, the hair elasticity is determined by measuring a Young’s Modulus of hair. In some instances, the hair color is determined by a color fade assay. In some instances, the hair strength is determined by a break stress. In some instances, the hair luster is determined by polarized spectroscopy, imaging, or both. In some instances, the hair porosity is determined by measuring a density of hair.

[0038] In some embodiments, any composition provided herein comprises one or more additional agents (such as a solvent, humectant, preservative, chelating agent, stabilizing agent, buffering agent, rheology modifying agent, sebum regulating agent, fragrance, excipients and the like). In certain instances, addition of one or more additional agents to any composition provided herein improve absorption of (e.g., odor binding proteins in) compositions provided herein.

[0039] In certain embodiments, the pH of a composition (e.g., a composition provided herein) is adjusted (e.g., using an acid, base, and / or buffer). In some embodiments, the pH of any composition provided herein is adjusted and / or maintained with a buffering agent (e.g., a buffering agent provided herein). In some instances, pH of a composition provided herein is important for the components of the composition to function properly (e.g., odor binding protein, absorbing agents,WSGR Docket No.63230-728.601 sebum regulating agents, and / or the like). In specific embodiments, a buffering agent (e.g., a buffering agent provided herein) is used to raise the pH of the composition. In yet more specific embodiments, a buffering agent (e.g., a buffering agent provided herein) is used to lower the pH of the composition.

[0040] In certain embodiments, pH of a composition (e.g., a composition provided herein) is adjusted to a pH from about 6 to about 9. In some embodiments, pH of a composition (e.g., a composition provided herein) is adjusted to a pH from about 6.5 to about 8.5. In certain embodiment, pH of a composition (e.g., a composition provided herein) is adjusted to a pH from about 6.8 to about 8.2. In specific embodiments, pH of a composition (e.g., a composition provided herein) is adjusted to a pH from about 7 to about 7.5. In yet more specific embodiments, pH of a composition (e.g., prior to adding an odor binding protein) is adjusted to a pH from about 6.8 to about 7.2. In still more specific embodiments, pH of a composition (e.g., a non-aerosol, hydroalcoholic formulation of a composition provided herein) is adjusted to a pH from about 7 to about 7.5. In yet more specific embodiments, pH of a composition (e.g., a non-aerosol, hydroalcoholic formulation of a composition provided herein) is adjusted to a pH no more than about 7.5. In yet more specific embodiments, pH of a composition (e.g., a non-aerosol, hydroalcoholic formulation of a composition provided herein) is adjusted to a pH no less than about 7.

[0041] In certain embodiments, application of a composition (e.g., a composition provided herein provided to the hair and / or skin of an individual) reduces malodor levels where applied, when compared to a baseline measurement. In certain instances, malodor levels are evaluated by trained odor graders (e.g., such as provided herein in Table 2). In some instances, baseline measurement refers to the malodor levels measured in the hair and / or skin of individuals that refrained from washing their hair and refrained from using any hair or scalp products for four days prior to testing and prior to administration of a composition (e.g., non-aerosol, hydroalcoholic formulations of compositions provided herein). In certain instances, the mean odor difference compared to the baseline measurement persists for about 24 to about 72 hours or more after administration. In certain instances, the mean odor difference compared to the baseline measurement is maintained at a sustained level immediately after administration to about 24 hours after administration.

[0042] In specific embodiments, the mean odor difference compared to the baseline measurement in individuals administered compositions provided herein when measured immediately after administration comprises a reduction of about 2 to about 7. In yet more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured immediately after administration comprises a reduction of about 3 to about 6. In still more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured immediately after administration comprises a reduction of about 5.WSGR Docket No.63230-728.601

[0043] In yet more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 12 hours after administration comprises a reduction of about to 2 to about 7. In still more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 12 hours after administration comprises a reduction of about 3 to about 6. In yet more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 12 hours after administration comprises a reduction of about 5.

[0044] In still more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 24 hours after administration comprises a reduction of about 2 to about 6. In yet more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 24 hours after administration comprises a reduction of about 3 to about 5. In still more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 24 hours after administration comprises a reduction of about 4.

[0045] In yet more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 48 hours after administration comprises a reduction of about 2 to about 5. In still more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 48 hours after administration comprises a reduction of about 3 to about 4. In yet more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 48 hours after administration comprises a reduction of about 3.5.

[0046] In still more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 72 hours after administration comprises a reduction of about 1 to about 4. In yet more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 72 hours after administration comprises a reduction of about 2 to 3. In still more specific embodiments, the mean odor difference compared to the baseline measurement in individuals when measured about 72 hours after administration comprises a reduction of about 2.5.

[0047] In certain embodiments, application of a composition (e.g., a composition provided herein provided to the hair and / or skin of an individual) reduces sebum levels when compared to a baseline measurement. In certain embodiments, sebum is measured with any suitable device or technique (e.g., a Sebumeter). In some instances, sebum levels are measured with a Sebumeter, a device used to assess skin surface sebum levels on an individual. A Sebumeter measures sebum by application of a specialized probe composed of a sebum sensitive film on its surface and results are expressed in g / cm2, mg / cm2, g / cm2, and the like. In some instances, sebum levels are measured with Sebutape, a measurement technique used to assess the seborrheic activity of skin pores in anWSGR Docket No.63230-728.601 individual. Sebutape measurement is performed by applying a patch of a transparent film that collects skin surface sebum. Active pores filled of sebum block the light and form spots on the film which is subsequently analyzed by image analysis or visually using a graded scale.

[0048] In certain embodiments, baseline measurement refers to the amount of sebum measured in individuals that refrained from washing their hair and using any hair or scalp products for four days prior to testing and prior to administration of a composition (e.g., non-aerosol, hydroalcoholic formulations of compositions provided herein). In certain instances, the mean sebum difference compared to the baseline measurement persists for about 24 to about 72 hours or more after administration. In certain instances, the mean sebum difference compared to the baseline measurement is maintained at a sustained level immediately after administration to about 24 hours after administration.

[0049] In specific embodiments, the mean sebum difference compared to the baseline measurement in individuals administered compositions provided herein when measured immediately after administration comprises a reduction of about 1 to about 20 g / cm2. In yet more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured immediately after administration comprises a reduction of about 5 to about 15 g / cm2. In still more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured immediately after administration comprises a reduction of about 10 g / cm2.

[0050] In yet more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 12 hours after administration comprises a reduction of about to 1 to about 19 g / cm2. In still more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 12 hours after administration comprises a reduction of about 5 to about 14 g / cm2. In yet more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 12 hours after administration comprises a reduction of about 9 g / cm2.

[0051] In still more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 24 hours after administration comprises a reduction of about 1 to about 17 g / cm2. In yet more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 24 hours after administration comprises a reduction of about 3 to about 12 g / cm2. In still more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 24 hours after administration comprises a reduction of about 7 g / cm2.

[0052] In yet more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 48 hours after administration comprises a reduction of about 1 to about 15 g / cm2. In still more specific embodiments, the mean sebumWSGR Docket No.63230-728.601 difference compared to the baseline measurement in individuals when measured about 48 hours after administration comprises a reduction of about 2 to about 10 g / cm2. In yet more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 48 hours after administration comprises a reduction of about 5.5 g / cm2.

[0053] In still more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 72 hours after administration comprises a reduction of about 1 to about 8 g / cm2. In yet more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 72 hours after administration comprises a reduction of about 2 to 6 g / cm2. In still more specific embodiments, the mean sebum difference compared to the baseline measurement in individuals when measured about 72 hours after administration comprises a reduction of about 4 g / cm2.

[0054] In some embodiments, application of a composition (e.g., a composition provided herein provided to the hair and / or skin of an individual) protects the area where the composition is applied, e.g., hair and / or skin of individuals. In some embodiments, application of a composition (e.g., a composition provided herein provided to the hair and / or skin of an individual) increases or maintains a hair property of hair or scalp as compared to the hair property of hair or scalp not applied with the composition. In some embodiments, application of a composition (e.g., a composition provided herein provided to the hair and / or skin of an individual) increases a hair property of hair or scalp as compared to the hair property of hair or scalp not applied with the composition. In some embodiments, application of a composition (e.g., a composition provided herein provided to the hair and / or skin of an individual) maintains a hair property of hair or scalp as compared to the hair property of hair or scalp not applied with the composition. In some embodiments, application of a composition (e.g., a composition provided herein provided to the hair and / or skin of an individual) increases a hair property where applied, when compared to a baseline measurement. In some instances, as described herein, the hair property refers to various aspects of hair characteristics, e.g., hair strength, hair color, hair elasticity, hair luster, hair porosity, or a combination thereof.

[0055] In some instances, the hair property can be determined using appropriate tests or measurements. In some instances, the hair elasticity is determined by measuring a Young’s Modulus of hair. In certain embodiments, the Young’s Modulus is measured using a tensiometer. In some instances, the hair color is determined by a color fade assay. In some instances, the hair strength is determined by a break stress. In certain embodiments, the break stress is measured using a tensiometer. In some instances, the hair luster is determined by polarized spectroscopy, imaging (e.g., scanning electron microscopy (SEM)), or both. In some instances, the hair porosity is determined by measuring a density of hair. In some embodiments, hair porosity is determined by a strand test, wherein hair is submerged in water.WSGR Docket No.63230-728.601

[0056] In some embodiments, the composition is applied to the hair prior to heat application. In some instances, as described herein, the heat application comprises exposing of hair and / or skin of an individual to heat such as using a hair styling tool, including but not limited to, hair dryer (or hood dryer), blow-dryer, straightener (e.g., flat iron), curling iron, curling wand, styler, heated brush / comb, etc., or a combination thereof. In some embodiments, the heat application comprises hair styling tools comprising a dryer, a straightener, a curling iron, a styler, a heated brush, or a heated comb. In some instances, application of the composition reduces damage caused by heat application.

[0057] In certain embodiments, compositions (e.g., compositions provided herein) are formulated as products for use by individuals. In some embodiments, compositions provided herein are formulated as products such as deodorants, shampoos, conditioners, hair conditioners, hair shampoos, dry shampoos, dry conditioners, leave in conditioners, hair masks, face washes, sunscreens, body washes, hand lotions, body lotions, face lotions, body moisturizers, face moisturizers, hair products, makeup removers, shaving creams, shaving gels, lip balms, hair styling products, and the like. In specific embodiments, a composition (e.g., a composition provided herein) is formulated as a hair product. In yet more specific embodiments, a composition (e.g., a composition provided herein) is formulated as a hair product (e.g., a dry shampoo). In still more specific embodiments, a composition (e.g., a composition provided herein) is formulated as a dry shampoo. In yet more specific embodiments, a composition (e.g., a composition provided herein) is formulated as a deodorant. In still more specific embodiments, a composition (e.g., a composition provided herein) is formulated as a hygiene product (e.g., a body wash). In some embodiments, compositions are formulated as a body deodorizer, a body wipe, a hair styling product, a hand soap, a foot cream, a foot soak, a bath bomb, a bath salt, a body scrub, a face mask, an underarm mask, a hair perfume, a style refresher, or scalp refresher, or a combination of two or more thereof.

[0058] In some embodiments, the compositions (e.g., compositions provided herein) are formulated as a product for administering to hair prior to heat application. In some instances, the compositions reduce damage caused by heat application. In some embodiments, damage caused by heat application comprises decreasing a hair property comprising decreasing hair strength, decreasing hair color, decreasing hair elasticity, decreasing hair luster, decreasing hair porosity, or a combination thereof. In some embodiments, damage caused by heat application comprises decreasing a hair property comprising decreasing hair strength, decreasing hair elasticity, decreasing hair luster, decreasing hair porosity, or a combination thereof. In some embodiments, the decreasinghair elasticity comprises reducing heat-induced conversion of alpha-keratin ( -keratin) to beta-keratin ( -keratin).

[0059] In some embodiments, application of the composition reduces conversion of -keratin to -keratin by about 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100%. In someWSGR Docket No.63230-728.601 embodiments, application of the composition reduces conversion of -keratin to -keratin by at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100%. In some embodiments, application of the composition reduces conversion of -keratin to -keratin by at most 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100%. In some embodiments, application of the composition reduces conversion of a-keratin to b-keratin by about 10% to about 100%, about 20% to about 100%, about 30% to about 100%, about 40% to about 100%, about 50% to about 100%, about 60% to about 100%, about 70% to about 100%, about 80% to about 100%, or about 90% to about 100%.

[0060] In some embodiments, the amount of -keratin, -keratin, or both is determined by circular dichroism (CD), wide-angle x-ray scattering (WAXS), or both.

[0061] In some embodiments, hair applied with the composition maintains hair porosity as compared to hair not applied with the composition. In some embodiments, porosity of hair is determined by measuring a density of hair. In some embodiments, hair porosity is determined by placing a tress of hair applied with the composition and treated with heat in water, wherein if the tress of hair sinks, then the hair is not porous. Conversely, in some instances, if the tress of hair floats, then the hair is porous. In some embodiments, if the tress of hair floats, then the hair is porous, and the tress of hair is determined to be heat damaged. In some embodiments, the tress of hair treated with the composition described herein has the same porosity as compared to a tress of hair not treated with the composition and not treated with heat.

[0062] In certain embodiments, compositions (e.g., compositions provided herein) and formulations of such compositions are prepared using any suitable method (e.g., by combining composition components in suitable sequence and amount under suitable conditions (e.g., such as temperature, pH, and the like)). In specific embodiments, compositions (e.g., compositions provided herein) are prepared with particular process instructions (e.g., such as provided in Example 2). In certain embodiments, compositions provided herein are formulated as suspensions (e.g., such that that active components of compositions are uniformly distributed throughout). In some embodiments, compositions (e.g., compositions provided herein) are formulated as non-aerosol formulations (e.g., using any suitable method). In specific embodiments, compositions provided herein are formulated as non-aerosol, high power content gel biphase formulations. In yet more specific embodiments, compositions provided herein are formulated as hydroalcoholic, high power content gel biphase formulations. In still more specific embodiments, compositions provided herein are formulated as non-aerosol, hydroalcoholic, high powder content gel biphase formulations.

[0063] In some embodiments, the OBP is modified to combine the binding abilities of a native OBP with an additional domain. In some cases, the additional domain enhances the OBP’s binding strength to hair fibers.

[0064] In one aspect, compositions (e.g., a composition provided herein) comprise an odor binding protein (OBP). In some embodiments, the OBP is produced through recombinant proteinWSGR Docket No.63230-728.601 production techniques. In some embodiments, the OBP selectively binds to and removes an odorous compound, e.g., in the same or similar manner to its native counterpart found in a mammals' nasal cavity. Native OBPs belong to the lipocalin protein supergroup, with a three-dimensional beta-barrel structure that effectively traps specific odors through non-covalent interactions. In some embodiments, the OBP herein traps odors through non-covalent interactions.

[0065] In some embodiments, OBP liberates a fragrance compound when it is in the presences of higher concentrations of certain odor compounds. In some cases, the OBP has a different binding affinity to different compounds based on specific delta G binding energies. Some compounds have stronger negative delta G values meaning stronger binding to the OBP. Examples of the relevant human odor compounds such isovaleric acid and skatole with good binding energies. In some cases, the OBP enhances the delivery of fragrance compounds due to competitive binding effects.

[0066] In some embodiments, the OBP disclosed herein comprise an odor-binding protein (OBP) or an odor-like binding peptide. In some embodiments, the odor-like binding peptide refers to a peptide, including a synthetic peptide, having a similar secondary structure, tertiary structure, or amino acid sequence, or a combination of two or more thereof, to a wild-type OBP (e.g., any one of SEQ ID NOS: 1-20), or a fragment of a wild-type OBP. Table 3 provides example embodiments of OBP. In some embodiments, a fragment includes a sequence having at least 4, 5, 6, 7, 8, 9, or 10 amino acids 100% identical to a sequence of wild-type OBP. Non-limiting examples of OBP include SEQ ID NOS: 1-82.

[0067] In some embodiments, the OBP comprises an isolated or artificial unmodified protein with at least 90% of identity to an amino acid sequence selected from any one of SEQ ID NOS: 1- 82, or mixtures thereof, e.g., 91% identical, 92% identical, 93% identical, 94% identical, 95% identical, 96% identical, 97% identical, 98% identical, 99% identical or 100% identical.

[0068] In some embodiments, the OBP comprises an isolated or artificial unmodified protein with at least 80% of identity to an amino acid sequence selected from any one of SEQ ID NOS: 1- 82, or mixtures thereof, e.g., 81% identical, 82% identical, 83% identical, 84% identical, 85% identical, 86% identical, 87% identical, 88% identical, or 99% identical.

[0069] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 1. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 2. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 3. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%,WSGR Docket No.63230-728.601 99%, or 100% identical to SEQ ID NO: 4. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 5. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 6. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 7. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 8. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 9. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 10. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 11. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 12. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 13. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 14. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 15. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 16. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 17. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 18. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 19. In some embodiments, the OBPWSGR Docket No.63230-728.601 comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 20. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 21-82.

[0070] In some embodiments, the OBP is a fusion protein comprising an OBP region and a keratin or keratin-like peptide. The OBP region may have a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 1-82. The fusion protein may bind to an odor compound. The fusion protein may bind with hair, skin, and / or nails. The fusion protein may bind with high affinity. The fusion protein may repair keratinous fiber damage through the formation of new disulfide bonds between the fusion protein and the keratin. The fusion protein may have a sequence comprising one or more cysteine amino acids. The one or more cysteine amino acids may form one or more disulfide bonds with one or more cysteine amino acids in the hair, skin, and / or nails. The formation of new disulfide bonds may help to restore the mechanical properties of the hair, skin, and / or nails. The formation of new disulfide bonds may improve elasticity, resistance, and / or appearance of hair. The keratin or keratin-like peptide may have a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In some embodiments, the fusion protein comprises the OBP connected to the keratin, keratin-like peptide or keratin associated protein via a linker. The linker may be an amino acid linker.

[0071] In some embodiments, the fusion protein comprises a wild-type keratin peptide, a functional fragment of a wild-type keratin peptide, or a peptide having at least 90% identity to a wild-type keratin peptide or a functional fragment of a wild-type keratin peptide. The wild-type keratin peptide may be keratin 85 having SEQ ID NO: 90. The wild-type peptide keratin peptide may comprise SEQ ID NO: 91, 92, 93, 94 or 95. In some embodiments, the fusion protein forms one or more disulfide bonds with hair. In some embodiments, the fusion protein forms one or more disulfide bonds with skin. In some embodiments, the fusion protein forms one or more disulfide bonds with nails.

[0072] In a non-limiting example embodiment, a functional fragment of a wild-type keratin peptide comprises at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 contiguous amino acids of a wild- type keratin peptide. In a non-limiting example embodiment, a functional fragment of a wild-type keratin peptide comprises at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 amino acids having at least 90% identity to a wild-type keratin peptide. In a non-limiting example embodiment, a functional fragment of a wild-type keratin peptide comprises at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 amino acids, where the at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 amino acids comprise one orWSGR Docket No.63230-728.601 more cysteine amino acids. For instance, the one or more cysteine amino acids is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 223, 24, 25, 26 or 27 cysteine amino acids. In a non-limiting example embodiment, a functional fragment of a wild-type keratin peptide comprises at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 amino acids, where at least 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 30%, 40%, or 50% of the at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 amino acids are cysteine amino acids. A non-limiting example embodiment of a keratin or keratin peptide is provided in SEQ ID NO: 90. Table 11 provides example embodiments of keratin and keratin-like peptides.

[0073] In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 6-16 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 6 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 7 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 8 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 9 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 10 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 11 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 12 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 13 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 14 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 15 residues. In some embodiments, the number of amino acids in the keratin or keratin associated peptide component of the fusion protein is 16 residues.

[0074] In some embodiments, the keratin or keratin associated peptide of the fusion protein possess a high cysteine content in order to enrich certain properties of the keratin or keratin associated peptide, such as, for example, to enhance formation of intermolecular cross-linking. The total cysteine content may range from about 1% to about 10% of the total number of amino acids in the fusion protein. The total cysteine content may range from about 5% to about 40% of the total number of amino acids in the keratin or keratin associated peptide of the fusion protein. In some embodiments, the keratin or keratin associated peptide of the fusion protein / peptide comprises 2 cysteine residues. In some embodiments, the keratin or keratin associated peptide of the fusion protein comprises 3 cysteine residues. In some embodiments, the keratin or keratin associatedWSGR Docket No.63230-728.601 peptide of the fusion protein comprises 4 cysteine residues. In some embodiments, the keratin or keratin associated peptide of the fusion protein comprises 5 cysteine residues.

[0075] In some embodiments, the keratin or keratin associated peptide of the fusion protein / peptide comprises the peptide sequence (X3)kC(X3)5C(X3)k.

[0076] In some embodiments, each “X3” is independently glycine, alanine, valine, isoleucine, leucine, phenylalanine, proline, serine, threonine, asparagine, glutamine, cysteine, methionine, phenylalanine, tyrosine, tryptophan, aspartate, glutamate, histidine, lysine, or arginine.

[0077] In some embodiments, each “k” is independently an integer ranging from 0 to 3. If k is 2, then (X3)k has a first X3 and a second X3, where each X3 is independently glycine, alanine, valine, isoleucine, leucine, phenylalanine, proline, serine, threonine, asparagine, glutamine, cysteine, methionine, phenylalanine, tyrosine, tryptophan, aspartate, glutamate, histidine, lysine, or arginine. If k is 3, then (X3)k has a first X3, a second X3, and a third X3, where each X3 is independently glycine, alanine, valine, isoleucine, leucine, phenylalanine, proline, serine, threonine, asparagine, glutamine, cysteine, methionine, phenylalanine, tyrosine, tryptophan, aspartate, glutamate, histidine, lysine, or arginine. (X3)5 has a first X3, a second X3, a third X3, a fourth X3, and a fifth X3, where each X3 is independently glycine, alanine, valine, isoleucine, leucine, phenylalanine, proline, serine, threonine, asparagine, glutamine, cysteine, methionine, phenylalanine, tyrosine, tryptophan, aspartate, glutamate, histidine, lysine, or arginine.

[0078] In some embodiments, the keratin or keratin associated peptide component of the fusion protein comprises: GGVCGPSPPCITT (SEQ ID NO: 91), GGVCGPSPPC (SEQ ID NO: 92), CGPSPPCITT (SEQ ID NO: 93), CGPSPPC (SEQ ID NO: 94), GVCGPSPPC (SEQ ID NO: 95), or a sequence of SEQ ID NOS: 96-112, or a combination of two or more thereof.

[0079] In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 91. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 92. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 93. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 94. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 95. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 96. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 97. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 98. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 99. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 100. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 101. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 102. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO:WSGR Docket No.63230-728.601 103. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 104. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 105. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 106. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 107. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 108. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 109. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 110. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 111. In some embodiments, the keratin or keratin associated peptide sequence comprises SEQ ID NO: 112.

[0080] In some embodiments, a keratin associated peptide includes a peptide that forms a disulfide bond with wild-type keratin. In some embodiments, a keratin associated peptide comprises about or at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 amino acids, and the about or at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16 amino acids are at least 90% identical to a wild-type keratin peptide sequence. The wild-type keratin peptide may be keratin 85 having SEQ ID NO: 90. The wild-type peptide keratin peptide may comprise SEQ ID NO: 91, 92, 93, 94, or 95.

[0081] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 1, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 1, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 1, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 1, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical toWSGR Docket No.63230-728.601 SEQ ID NO: 1, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 1, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0082] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 2, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 2, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 2, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 2, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 2, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 2, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0083] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%,WSGR Docket No.63230-728.601 99%, or 100% identical to SEQ ID NO: 3, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 3, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 3, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 3, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 3, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 3, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0084] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 4, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 4, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, orWSGR Docket No.63230-728.601 100% identical to SEQ ID NO: 4, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 4, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 4, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 4, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0085] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 5, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 5, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 5, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 5, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical toWSGR Docket No.63230-728.601 SEQ ID NO: 5, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 5, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0086] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 6, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 6, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 6, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 6, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 6, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 6, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0087] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%,WSGR Docket No.63230-728.601 99%, or 100% identical to SEQ ID NO: 7, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 7, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 7, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 7, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 7, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 7, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0088] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 8, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 8, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, orWSGR Docket No.63230-728.601 100% identical to SEQ ID NO: 8, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 8, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 8, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 8, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0089] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 9, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 9, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 9, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 9, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical toWSGR Docket No.63230-728.601 SEQ ID NO: 9, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 9, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0090] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 10, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 10, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 10, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 10, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 10, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 10, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0091] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%,WSGR Docket No.63230-728.601 99%, or 100% identical to SEQ ID NO: 11, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 11, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 11, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 11, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 11, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 11, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0092] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 12, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 12, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, orWSGR Docket No.63230-728.601 100% identical to SEQ ID NO: 12, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 12, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 12, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 12, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0093] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 13, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 13, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 13, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 13, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identicalWSGR Docket No.63230-728.601 to SEQ ID NO: 13, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 13, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0094] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 14, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 14, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 14, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 14, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 14, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 14, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0095] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%,WSGR Docket No.63230-728.601 99%, or 100% identical to SEQ ID NO: 15, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 15, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 15, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 15, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 15, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 15, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0096] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 16, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 16, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, orWSGR Docket No.63230-728.601 100% identical to SEQ ID NO: 16, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 16, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 16, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 16, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0097] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 17, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 17, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 17, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 17, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identicalWSGR Docket No.63230-728.601 to SEQ ID NO: 17, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 17, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0098] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 18, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 18, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 18, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 18, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 18, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 18, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0099] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%,WSGR Docket No.63230-728.601 99%, or 100% identical to SEQ ID NO: 19, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 19, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 19, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 19, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 19, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 19, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0100] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 20, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 91-112. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 20, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91. In a non- limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, orWSGR Docket No.63230-728.601 100% identical to SEQ ID NO: 20, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 20, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 20, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94. In a non-limiting example, the OBP comprises the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 20, and the sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95.

[0101] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 91, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 1-82.

[0102] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 92, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 1-82.

[0103] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 93, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 1-82.

[0104] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 94, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 1-82.WSGR Docket No.63230-728.601

[0105] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 95, and a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 1-82.

[0106] In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOS: 201-340. In some embodiments, (X1) comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 401. In some embodiments, (X1) comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 402. In some embodiments, (X1) comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 403. In some embodiments, (X1) comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 404. In some embodiments, (X1) comprises LA of Table 13. In some embodiments, (X1) comprises LB of Table 13. In some embodiments, (X1) comprises LC of Table 13. In some embodiments, (X1) comprises LD of Table 13.

[0107] In some embodiments, the OBP comprises a linker, e.g., a linker between the OBP region and the keratin or keratin like peptide. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 401. In some embodiments, the linker comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 401. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 402. In some embodiments, the linker comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 402. In some embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 403. In some embodiments, the linker comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 403. In someWSGR Docket No.63230-728.601 embodiments, the OBP comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 404. In some embodiments, the linker comprises a sequence about or at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to SEQ ID NO: 404. In some embodiments, the linker comprises LA of Table 13. In some embodiments, the linker comprises LB of Table 13. In some embodiments, the linker comprises LC of Table 13. In some embodiments, the linker comprises LD of Table 13. Table 10. Non-Limiting Example OBP SequencesWSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601 62 63 64 65 66 67 68 69 70 71 72 73WSGR Docket No.63230-728.601Table 11. Non-Limiting Example Keratin / Keratin-like Peptide SequencesWSGR Docket No.63230-728.601Table 12. Non-Limiting Example OBP (Fusion Protein) SequencesWSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601WSGR Docket No.63230-728.601Table 13. Non-Limiting Example Linker Sequences

[0108] In certain embodiments, about 0.001% to about 1% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding protein provided herein). In some embodiments, about 0.0025% to about 0.5% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding protein provided herein). In certain embodiments, about 0.005% to about 0.1% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding protein provided herein). In specific embodiments, about 0.009% to about 0.011% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding proteinWSGR Docket No.63230-728.601 provided herein). In still more specific embodiments, about 0.01% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding protein provided herein). In yet more specific embodiments, about 0.05% to about 0.07% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding protein provided herein). In specific embodiments, an odor binding protein in a composition (e.g., a composition provided herein) comprises e.g., a sequence at least about 80% identical to any one of SEQ ID NOS: 1-82, 201-340.

[0109] In some embodiments, a composition provided herein comprises an odor binding protein (e.g., an odor binding protein provided herein) at about 0.001% to about 1% (w / w) of the composition. In some embodiments, about 0.001% to about 0.002%, about 0.001% to about 0.004%, about 0.001% to about 0.006%, about 0.001% to about 0.008%, about 0.001% to about 0.01%, about 0.001% to about 0.015%, about 0.001% to about 0.05%, about 0.001% to about 0.1%, about 0.001% to about 0.25%, about 0.001% to about 0.5%, about 0.001% to about 1%, about 0.002% to about 0.004%, about 0.002% to about 0.006%, about 0.002% to about 0.008%, about 0.002% to about 0.01%, about 0.002% to about 0.015%, about 0.002% to about 0.05%, about 0.002% to about 0.1%, about 0.002% to about 0.25%, about 0.002% to about 0.5%, about 0.002% to about 1%, about 0.004% to about 0.006%, about 0.004% to about 0.008%, about 0.004% to about 0.01%, about 0.004% to about 0.015%, about 0.004% to about 0.05%, about 0.004% to about 0.1%, about 0.004% to about 0.25%, about 0.004% to about 0.5%, about 0.004% to about 1%, about 0.006% to about 0.008%, about 0.006% to about 0.01%, about 0.006% to about 0.015%, about 0.006% to about 0.05%, about 0.006% to about 0.1%, about 0.006% to about 0.25%, about 0.006% to about 0.5%, about 0.006% to about 1%, about 0.008% to about 0.01%, about 0.008% to about 0.015%, about 0.008% to about 0.05%, about 0.008% to about 0.1%, about 0.008% to about 0.25%, about 0.008% to about 0.5%, about 0.008% to about 1%, about 0.01% to about 0.015%, about 0.01% to about 0.05%, about 0.01% to about 0.1%, about 0.01% to about 0.25%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.015% to about 0.05%, about 0.015% to about 0.1%, about 0.015% to about 0.25%, about 0.015% to about 0.5%, about 0.015% to about 1%, about 0.05% to about 0.1%, about 0.05% to about 0.25%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.1% to about 0.25%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.25% to about 0.5%, about 0.25% to about 1%, or about 0.5% to about 1% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding protein provided herein). In some embodiments, about 0.001%, about 0.002%, about 0.004%, about 0.006%, about 0.008%, about 0.01%, about 0.015%, about 0.05%, about 0.1%, about 0.25%, about 0.5%, or about 1% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding protein provided herein). In some embodiments, at least about 0.001%, about 0.002%, about 0.004%, about 0.006%, about 0.008%, about 0.01%, about 0.015%, about 0.05%, about 0.1%, about 0.25%, or about 0.5% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding proteinWSGR Docket No.63230-728.601 provided herein). In some embodiments, not more than about 0.002%, about 0.004%, about 0.006%, about 0.008%, about 0.01%, about 0.015%, about 0.05%, about 0.1%, about 0.25%, about 0.5%, or about 1% (w / w) of a composition provided herein is an odor binding protein (e.g., an odor binding protein provided herein). In some embodiments, the composition comprising an odor binding protein maintains or increases a hair property to where applied, e.g., hair and / or skin of individuals, as compared to the hair property of hair not applied with the composition. In some embodiments, the composition comprising an odor binding protein increases a hair property to where applied, e.g., hair and / or skin of individuals, when compared to no application of the composition. In some embodiments, the composition comprising an odor binding protein increases a hair property to where applied, e.g., hair and / or skin of individuals, when compared to a baseline measurement. In some embodiments, the composition comprising an odor binding protein maintains a hair property to where applied, e.g., hair and / or skin of individuals, when compared to no application of the composition. In some embodiments, the composition comprising an odor binding protein maintains a hair property to where applied, e.g., hair and / or skin of individuals, when compared to a baseline measurement. In some embodiments, the composition comprising an odor binding protein is applied to hair prior to heat application.

[0110] In some aspects, compositions (e.g., a composition provided herein) comprise an absorbing agent. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) comprise an absorbing agent (such as oil absorbing agents). In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one absorbing agent, two absorbing agents, three absorbing agents, four absorbing agents, five absorbing agents, or more. In certain embodiments, an absorbing agent (e.g., an absorbing agent provided herein) is added to a composition (e.g., a composition provided herein, such as a non-aerosol formulation). In certain instances, absorbing agents are useful for reducing excess oils (e.g., on the scalp or hair of an individual) and are added to compositions (e.g., a non-aerosol formulation) provided herein for such purpose. In certain instances, absorbing agents are oil absorbing agents. In some instances, properties of the absorbing agents, such as multiporous structure allows for absorption of oils and sebum (e.g., on the scalp and hair of an individual). In certain instances, the shape and structure of particles of absorbing agents absorb sweat and oils (e.g., from the skin of an individual). In some embodiments, the absorbing agent may physically absorb sebum and / or oil. In some embodiments, the absorbing agent my chemically absorb sebum and / or oil (e.g., by forming a covalent bond with the sebum and / or oil, interacting with the sebum and / or oil via intermolecular forces, such as ionic interactions, van der Waals interactions, and the like).

[0111] In some embodiments, an absorbing agent (e.g., an absorbing agent provided herein) comprises a compound comprising silicon (e.g., silica, silica silylate), silica derivatives, synthetic silica derivatives, silicate salts, carbonate salts, metal oxides, clay mineral powders (e.g., talc),WSGR Docket No.63230-728.601 and / or any combination of one or more thereof. In specific embodiments, the absorbing agent comprises a compound comprising silicon. In yet more specific embodiments, the absorbing agents comprises a compound comprising silicon, wherein the compound comprises silica, silica silylate, silica dimethyl silylate, silica dimethicone silylate, and / or the like. In certain embodiments, the absorbing agent comprises silica, spherical silica, fumed silica, precipitated silica, silicone-surface treated silica, hydroxyapatite, talc, mica, silica, magnesium silicate, synthetic fluorophlogopite, calcium silicate, aluminum silicate, bentonite, montmorillonite, silica silylate, silica dimethyl silylate, silica dimethicone silylate, starch, distarch phosphate, tapioca starch, oryza sativa (rice) starch, solanum tuberosum (potato) starch, zea mays (corn) starch, hydrolyzed corn starch, potato starch modified, corn starch modified, sodium polyacrylate starch, sodium carboxymethyl starch, calcium starch octenylsuccinate, sodium starch octenylsuccinate, aluminum starch octenylsuccinate, hydrolyzed corn starch octenylsuccinate, sodium hydroxypropyl oxidized starch succinate, hydrolyzed corn starch hydroxyethyl ether, hydroxypropyl starch phosphate, sodium hydroxypropyl starch phosphate, hydroxypropyl oxidized starch pg-trimonium chloride, starch hydroxypropyltrimonium chloride, dimethylimidazolidinone rice starch, nylon-12, methyl methacrylate crosspolymer (MMA), polymethylmethacrylate (PMMA), HDI / trimethylol hexyllactone crosspolymer, dimethicone / vinyl dimethicone crosspolymer, divinyldimethicone / dimethicone crosspolymer, dimethicone crosspolymer, polysilicone-11, polymethylsilsesquioxane (PSQ), polymethylsilsesquioxane / trimethylsiloxysilicate, divinyldimethicone / dimethicone / phenylsilsesquioxane crosspolymer, polydimethylsiloxane, lauroyl lysine, talc, boron nitride, bismuth oxychloride, alumina, magnesium aluminum silicate, kaolin, montmorillonite, bentonite, hectorite, illite, perlite, calcite, clay, canadian colloidal clay, Moroccan lava clay, hydroxyapatite, disteardimonium hectorite, stearalkonium hectorite, quaternium-90 sepiolite, quaternium-90 montmorillonite, quaternium-18 bentonite, calcium carbonate, magnesium carbonate, silt, sea silt, mica, synthetic fluorphlogopite, calcium silicate, magnesium aluminum silicate, sodium potassium aluminum silicate, calcium sodium borosilicate, calcium aluminum borosilicate, nephrite powder, titanium dioxide, tin oxide, synthetic sapphire, carbon, charcoal, iron oxides, dextrin, maltodextrin, hydroxypropyltrimonium maltodextrin crosspolymer, inulin, cellulose, cellulose acetate, cellulose gum, microcrystalline cellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropyl methylcellulose, diatomaceous earth, olea europaea (olive) seed powder, zea mays (corn) bran extract, maranta arundinacea root extract (arrowroot starch), hordeum vulgare (barley) seed flour, or a combination of two or more thereof.

[0112] In specific embodiments, an absorbing agent in a composition (e.g., a composition provided herein) comprises hydroxyapatite. In yet more specific embodiments, an absorbing agent in a composition (e.g., a composition provided herein) comprises silica. In still more specificWSGR Docket No.63230-728.601 embodiments, an absorbing agent in a composition (e.g., a composition provided herein) comprises magnesium silicate.

[0113] In certain embodiments, a composition (e.g., a composition provided herein) comprises an absorbing agent (e.g., an absorbing agent provided herein). In certain embodiments, about 0.01% to about 40% (w / w) of a composition provided herein is an absorbing agent (e.g., an absorbing agent provided herein). In some embodiments, about 1% to about 25% (w / w) of a composition provided herein is an absorbing agent (e.g., an absorbing agent provided herein). In certain embodiments, about 2% to about 15% (w / w) of a composition provided herein is an absorbing agent (e.g., an absorbing agent provided herein).

[0114] In certain embodiments, a composition (e.g., a composition provided herein) is an absorbing agent, such as silica. In certain embodiments, about 0.01% to about 40% (w / w) of a composition provided herein is silica. In some embodiments, about 1% to about 25% (w / w) of a composition provided herein is silica. In certain embodiments, about 2% to about 15% (w / w) of a composition provided herein is silica. In specific embodiments, about 6% to about 20% (w / w) of a composition provided herein is silica. In still more specific embodiments, about 2% to about 4% (w / w) of a composition provided herein is silica. In yet more specific embodiments, about 12% to about 16% (w / w) of a composition provided herein is silica. In still more specific embodiments, about 0.5% to about 5% (w / w) of a composition provided herein is silica. In yet more specific embodiments, about 8% (w / w) of a composition provided herein is silica. In still more specific embodiments, about 25% (w / w) of a composition provided herein is silica. In yet more specific embodiments, about 10% (w / w) of a composition provided herein is silica. In still more specific embodiments, about 25% (w / w) of a composition provided herein is silica.

[0115] In some embodiments, a composition provided herein comprises silica at about 0.01% to about 40% (w / w) of a total weight of the composition. In some embodiments, about 0.01% to about 0.1%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2%, about 0.01% to about 5%, about 0.01% to about 8%, about 0.01% to about 10%, about 0.01% to about 15%, about 0.01% to about 23%, about 0.01% to about 30%, about 0.01% to about 40%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2%, about 0.1% to about 5%, about 0.1% to about 8%, about 0.1% to about 10%, about 0.1% to about 15%, about 0.1% to about 23%, about 0.1% to about 30%, about 0.1% to about 40%, about 0.5% to about 1%, about 0.5% to about 2%, about 0.5% to about 5%, about 0.5% to about 8%, about 0.5% to about 10%, about 0.5% to about 15%, about 0.5% to about 23%, about 0.5% to about 30%, about 0.5% to about 40%, about 1% to about 2%, about 1% to about 5%, about 1% to about 8%, about 1% to about 10%, about 1% to about 15%, about 1% to about 23%, about 1% to about 30%, about 1% to about 40%, about 2% to about 5%, about 2% to about 8%, about 2% to about 10%, about 2% to about 15%, about 2% to about 23%, about 2% to about 30%, about 2% to about 40%, about 5% to about 8%, about 5% to aboutWSGR Docket No.63230-728.601 10%, about 5% to about 15%, about 5% to about 23%, about 5% to about 30%, about 5% to about 40%, about 8% to about 10%, about 8% to about 15%, about 8% to about 23%, about 8% to about 30%, about 8% to about 40%, about 10% to about 15%, about 10% to about 23%, about 10% to about 30%, about 10% to about 40%, about 15% to about 23%, about 15% to about 30%, about 15% to about 40%, about 23% to about 30%, about 23% to about 40%, or about 30% to about 40% (w / w) of a composition provided herein comprises silica. In some embodiments, about 0.01%, about 0.1%, about 0.5%, about 1%, about 2%, about 5%, about 8%, about 10%, about 15%, about 23%, about 30%, or about 40% (w / w) of a composition provided herein comprises silica. In some embodiments, at least about 0.01%, about 0.1%, about 0.5%, about 1%, about 2%, about 5%, about 8%, about 10%, about 15%, about 23%, or about 30% (w / w) of a composition provided herein is silica. In some embodiments, not more than about 0.1%, about 0.5%, about 1%, about 2%, about 5%, about 8%, about 10%, about 15%, about 23%, about 30%, or about 40% (w / w) of a composition provided herein is silica.

[0116] In some instances, the addition of silica to a composition provided herein is useful for reducing oils and / or sebum (e.g., in the scalp or hair of an individual).

[0117] In some aspects, compositions (e.g., a composition provided herein) comprise a sebum regulating agent. In specific embodiments, additional agents of composition (e.g., a composition provided herein) comprise a sebum regulating agent. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one sebum regulating agent, two sebum regulating agents, three sebum regulating agents, four sebum regulating agents, five sebum regulating agents, or more. In some instances, sebum regulating agents (e.g., a sebum regulating agent provided herein) are useful as sebum regulators (e.g., exfoliating and regulating levels of sebum on the scalp of an individual), and their inclusion in compositions (e.g., a composition provided herein, such as a non-aerosol formulation) furthers such purpose. In certain instances, sebum regulating agents are useful for other inherent properties, such as antioxidant, soothing, regenerative and tissue repair activities (e.g., in an individual). In certain embodiments, sebum regulating agents provided herein (e.g., microalga extracts and metabolites) possess biochemical characteristics and contain bioactive compounds (e.g., with antimicrobial properties). In certain instances, sebum regulating agents provided herein (e.g., Tetraselmis Suecica extract) produce vitamin C which is a reactive oxygen species scavenger and protect against lipid hydroperoxyl radical reduction; and further, such sebum regulating agents are rich in carotenoids such as xanthophylls, lutein, violaxanthin, neoxanthin, T. suecica antheraxanthin and loroaxanthin esters. In some instances, sebum regulating agents provided herein have emulsifying and foaming properties (e.g., useful for reducing sebum and other oils in individuals).

[0118] In certain embodiments, a sebum regulating agent (e.g., a sebum regulating agent provided herein) can comprise tea tree oils and / or extracts (e.g., green tea emulsions), salicylic acids,WSGR Docket No.63230-728.601 fruit extracts (e.g., avocado extract), microalga extracts, and the like. In some embodiments, a sebum regulating agent (e.g., a sebum regulating agent provided herein) can comprise salicylic acid, microalgae extracts, green tea emulsions, avocado extract, Opuntia ficus-indica stem extract, Anetholea anisate leaf extract, Tetraselmis Suecica extract, Alteromonas ferment extract, Pseudoalteromonas ferment extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Saccharum officinarum (sugarcane) extract, Rhodomyrtus tomentosa fruit extract, Hedychium coronarium root extract, Epilobium angustifolium flower / leaf / stem extract, Tremella fuciformis sporocarp extract, salicylic acid, and / or combinations of one or more thereof. In specific embodiments, a sebum regulating agent in a composition (e.g., a composition provided herein) comprises Tetraselmis Suecica extract. In yet more specific embodiments, a sebum regulating agent in a composition (e.g., a composition provided herein) comprises green tea emulsions.

[0119] In certain embodiments, about 0.0001% to about 1% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In some embodiments, about .0005% to about 0.5% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In certain embodiments, about 0.001% to about 0.05% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In specific embodiments, about 0.005% to about 0.015% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In yet more specific embodiments, about 0.006% to about 0.01% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In still more specific embodiments, about 0.0089% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In yet more specific embodiments, about 0.5% to about 0.8% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In still more specific embodiments, about 0.002% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In specific embodiments, the sebum regulating agent comprises Tetraselmis Suecica extract.

[0120] In some embodiments, a composition provided herein comprises a sebum regulating agent (e.g., a sebum regulating agent provided herein) at about 0.001% to about 1% (w / w) of the composition. In some embodiments, about 0.001% to about 0.002%, about 0.001% to about 0.003%, about 0.001% to about 0.005%, about 0.001% to about 0.006%, about 0.001% to about 0.008%, about 0.001% to about 0.0089%, about 0.001% to about 0.01%, about 0.001% to about 0.05%, about 0.001% to about 0.1%, about 0.001% to about 0.5%, about 0.001% to about 1%, about 0.002% to about 0.003%, about 0.002% to about 0.005%, about 0.002% to about 0.006%, about 0.002% to about 0.008%, about 0.002% to about 0.0089%, about 0.002% to about 0.01%, about 0.002% to about 0.05%, about 0.002% to about 0.1%, about 0.002% to about 0.5%, about 0.002% toWSGR Docket No.63230-728.601 about 1%, about 0.003% to about 0.005%, about 0.003% to about 0.006%, about 0.003% to about 0.008%, about 0.003% to about 0.0089%, about 0.003% to about 0.01%, about 0.003% to about 0.05%, about 0.003% to about 0.1%, about 0.003% to about 0.5%, about 0.003% to about 1%, about 0.005% to about 0.006%, about 0.005% to about 0.008%, about 0.005% to about 0.0089%, about 0.005% to about 0.01%, about 0.005% to about 0.05%, about 0.005% to about 0.1%, about 0.005% to about 0.5%, about 0.005% to about 1%, about 0.006% to about 0.008%, about 0.006% to about 0.0089%, about 0.006% to about 0.01%, about 0.006% to about 0.05%, about 0.006% to about 0.1%, about 0.006% to about 0.5%, about 0.006% to about 1%, about 0.008% to about 0.0089%, about 0.008% to about 0.01%, about 0.008% to about 0.05%, about 0.008% to about 0.1%, about 0.008% to about 0.5%, about 0.008% to about 1%, about 0.0089% to about 0.01%, about 0.0089% to about 0.05%, about 0.0089% to about 0.1%, about 0.0089% to about 0.5%, about 0.0089% to about 1%, about 0.01% to about 0.05%, about 0.01% to about 0.1%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.05% to about 0.1%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.1% to about 0.5%, about 0.1% to about 1%, or about 0.5% to about 1% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In some embodiments, about 0.001%, about 0.002%, about 0.003%, about 0.005%, about 0.006%, about 0.008%, about 0.0089%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, or about 1% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In some embodiments, at least about 0.001%, about 0.002%, about 0.003%, about 0.005%, about 0.006%, about 0.008%, about 0.0089%, about 0.01%, about 0.05%, about 0.1%, or about 0.5% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein). In some embodiments, not more than about 0.002%, about 0.003%, about 0.005%, about 0.006%, about 0.008%, about 0.0089%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, or about 1% (w / w) of a composition provided herein is a sebum regulating agent (e.g., a sebum regulating agent provided herein).

[0121] In some aspects, compositions (e.g., a composition provided herein) comprise an odor control agent. In some embodiments, the odor control agent comprises fullerene encapsulated in silica, magnesium hydroxide, magnesium carbonate hydroxide, shikimic acid, zinc pyrrolidone carboxylate, glycerin, Morinda citrifolia callus culture lysate, citric acid, maltodextrin, or soy ethyl morpholinium ethosulfate, or a combination of two or more thereof.

[0122] In some aspects, compositions (e.g., a composition provided herein) comprise a solvent. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) comprise a solvent. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one solvent, two solvents, three solvents, four solvents, five solvents, or more. In certain embodiments, a solvent (e.g., a solvent provided herein) is used to additional agents of a composition (e.g., a composition provided herein, such as a non-aerosol formulation).WSGR Docket No.63230-728.601

[0123] In some embodiments, solvents (e.g., a solvent provided herein) comprise any suitable solvent (such as an alcohol, water, or the like). In certain embodiments, solvents can comprise polar solvents, nonpolar solvents, water, alcohols (e.g., ethanol), denatured alcohols (e.g., denatured ethanol), polyols (e.g., glycerin), glycols, sugars (e.g., glucose, fructose, or the like), polyethylene glycols, and / or combinations of one or more thereof. In some embodiments, solvents can comprise water, mannitol, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, denatured ethanol, denatured methanol, denatured propanol, denatured isopropyl alcohol, denatured butanol, denatured pentanol, denatured hexanol, methanol, ethanol, propanol, isopropyl alcohol, butanol, pentanol, hexanol, glycerin, butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols, sorbitol, glucose, fructose, maltose, lactose, sucrose, PEG-4, PEG-6, PEG-8, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, and / or combinations of one or more thereof.

[0124] In certain embodiments, a solvent in a composition (e.g., a composition provided herein) comprises water. In some embodiments, the solvent in a composition (e.g., a composition provided herein) comprises glycerin. In certain embodiments, the solvent in a composition (e.g., a composition provided herein) comprises mannitol. In some embodiments, a solvent in a composition provided herein comprises an alcohol. In specific embodiments, the solvent in a composition (e.g., a composition provided herein) comprises denatured ethanol.

[0125] In certain embodiments, solvents (e.g., total solvent) comprise about 35% to about 99% by weight (w / w) of a composition (e.g., a composition provided herein). In some embodiments, solvents comprise about 60% to about 97% (w / w) of the composition. In certain embodiments, solvents comprise about 80% to about 95% (w / w) of the composition.

[0126] In certain embodiments, a composition (e.g., a composition provided herein) comprises a solvent. In certain embodiments, about 15% to about 95% (w / w) of a composition provided herein comprises a solvent (e.g., a solvent provided herein). In some embodiments, about 30% to about 90% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein). In certain embodiments, about 45% to about 85% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein).

[0127] In certain embodiments, a composition (e.g., a composition provided herein) comprises a solvent, such as water. In certain embodiments, the solvent in a composition (e.g., a composition provided herein) comprises water. In certain embodiments, about 15% to about 95% (w / w) of a composition provided herein is water. In some embodiments, about 30% to about 90% (w / w) of a composition provided herein is water. In certain embodiments, about 45% to about 85% (w / w) of a composition provided herein is water. In specific embodiments, about 65% to about 70% (w / w) of a composition provided herein is water. In yet more specific embodiments, about 20% to about 40%WSGR Docket No.63230-728.601 (w / w) of a composition provided herein is water. In still more specific embodiments, about 40% to about 45% (w / w) of a composition provided herein is water.

[0128] In some embodiments, a composition provided herein comprises water at about 15% to about 95% by weight (w / w) of the composition. In some embodiments, a composition provided herein comprises water (% w / w) at about 15% to about 25%, about 15% to about 40%, about 15% to about 45%, about 15% to about 55%, about 15% to about 60%, about 15% to about 65%, about 15% to about 68%, about 15% to about 70%, about 15% to about 75%, about 15% to about 85%, about 15% to about 95%, about 25% to about 40%, about 25% to about 45%, about 25% to about 55%, about 25% to about 60%, about 25% to about 65%, about 25% to about 68%, about 25% to about 70%, about 25% to about 75%, about 25% to about 85%, about 25% to about 95%, about 40% to about 45%, about 40% to about 55%, about 40% to about 60%, about 40% to about 65%, about 40% to about 68%, about 40% to about 70%, about 40% to about 75%, about 40% to about 85%, about 40% to about 95%, about 45% to about 55%, about 45% to about 60%, about 45% to about 65%, about 45% to about 68%, about 45% to about 70%, about 45% to about 75%, about 45% to about 85%, about 45% to about 95%, about 55% to about 60%, about 55% to about 65%, about 55% to about 68%, about 55% to about 70%, about 55% to about 75%, about 55% to about 85%, about 55% to about 95%, about 60% to about 65%, about 60% to about 68%, about 60% to about 70%, about 60% to about 75%, about 60% to about 85%, about 60% to about 95%, about 65% to about 68%, about 65% to about 70%, about 65% to about 75%, about 65% to about 85%, about 65% to about 95%, about 68% to about 70%, about 68% to about 75%, about 68% to about 85%, about 68% to about 95%, about 70% to about 75%, about 70% to about 85%, about 70% to about 95%, about 75% to about 85%, about 75% to about 95%, or about 85% to about 95% (w / w). In some embodiments, about 15%, about 25%, about 40%, about 45%, about 55%, about 60%, about 65%, about 68%, about 70%, about 75%, about 85%, or about 95% (w / w) of a composition provided herein is water. In some embodiments, at least about 15%, about 25%, about 40%, about 45%, about 55%, about 60%, about 65%, about 68%, about 70%, about 75%, or about 85% (w / w) of a composition provided herein is water. In some embodiments, not more than about 25%, about 40%, about 45%, about 55%, about 60%, about 65%, about 68%, about 70%, about 75%, about 85%, or about 95% (w / w) of a composition provided herein is water.

[0129] In certain instances, the addition of water to a composition provided herein is useful for dissolving one or more additional agents of the composition.

[0130] In certain embodiments, a composition (e.g., a composition provided herein) comprises a solvent (e.g., a solvent provided herein). In certain embodiments, about 0.01% to about 10% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein. In some embodiments, about 0.05% to about 5% (w / w) of a composition provided herein is a solvent (e.g., aWSGR Docket No.63230-728.601 solvent provided herein. In certain embodiments, about 0.1% to about 1% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein.

[0131] In certain embodiments, a composition (e.g., a composition provided herein) comprises a solvent, such as glycerin. In certain embodiments, about 0.01% to about 10% (w / w) of a composition provided herein is glycerin. In some embodiments, about 0.05% to about 5% (w / w) of a composition provided herein is glycerin. In certain embodiments, about 0.1% to about 1% (w / w) of a composition provided herein is glycerin. In some embodiments, about 1% to about 5% (w / w) of a composition provided herein is glycerin. In specific embodiments, about 0.1% to about 0.2% (w / w) of a composition provided herein is glycerin. In yet more specific embodiments, about 0.3% to about 0.5% (w / w) of a composition provided herein is glycerin. In still more specific embodiments, about 1.4% to about 2.5% (w / w) of a composition provided herein is glycerin. In yet more specific embodiments, about 0.4% (w / w) of a composition provided herein is glycerin. In still more specific embodiments, about 1% (w / w) of a composition provided herein is glycerin. In yet more specific embodiments, about 5% (w / w) of a composition provided herein is glycerin.

[0132] In some embodiments, a composition provided herein comprises glycerin at about 0.01% to about 10% (w / w) of the composition. In some embodiments, a composition provided herein comprises glycerin at about 0.01% to about 0.1%, about 0.01% to about 0.2%, about 0.01% to about 0.3%, about 0.01% to about 0.4%, about 0.01% to about 0.5%, about 0.01% to about 0.6%, about 0.01% to about 1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.01% to about 7.5%, about 0.01% to about 10%, about 0.1% to about 0.2%, about 0.1% to about 0.3%, about 0.1% to about 0.4%, about 0.1% to about 0.5%, about 0.1% to about 0.6%, about 0.1% to about 1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.1% to about 7.5%, about 0.1% to about 10%, about 0.2% to about 0.3%, about 0.2% to about 0.4%, about 0.2% to about 0.5%, about 0.2% to about 0.6%, about 0.2% to about 1%, about 0.2% to about 2.5%, about 0.2% to about 5%, about 0.2% to about 7.5%, about 0.2% to about 10%, about 0.3% to about 0.4%, about 0.3% to about 0.5%, about 0.3% to about 0.6%, about 0.3% to about 1%, about 0.3% to about 2.5%, about 0.3% to about 5%, about 0.3% to about 7.5%, about 0.3% to about 10%, about 0.4% to about 0.5%, about 0.4% to about 0.6%, about 0.4% to about 1%, about 0.4% to about 2.5%, about 0.4% to about 5%, about 0.4% to about 7.5%, about 0.4% to about 10%, about 0.5% to about 0.6%, about 0.5% to about 1%, about 0.5% to about 2.5%, about 0.5% to about 5%, about 0.5% to about 7.5%, about 0.5% to about 10%, about 0.6% to about 1%, about 0.6% to about 2.5%, about 0.6% to about 5%, about 0.6% to about 7.5%, about 0.6% to about 10%, about 1% to about 2.5%, about 1% to about 5%, about 1% to about 7.5%, about 1% to about 10%, about 2.5% to about 5%, about 2.5% to about 7.5%, about 2.5% to about 10%, about 5% to about 7.5%, about 5% to about 10%, or about 7.5% to about 10% (w / w). In some embodiments, about 0.01%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 1%, about 2.5%, about 5%, about 7.5%, or about 10% of theWSGR Docket No.63230-728.601 composition. In some embodiments, at least about 0.01%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 1%, about 2.5%, about 5%, or about 7.5% (w / w) of a composition provided herein is glycerin. In some embodiments, not more than about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 1%, about 2.5%, about 5%, about 7.5%, or about 10% (w / w) of a composition provided herein is glycerin.

[0133] In certain embodiments, a composition (e.g., a composition provided herein) comprises a solvent (e.g., a solvent provided herein). In certain embodiments, about 0.001% to about 5% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein). In some embodiments, about 0.01% to about 1% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein). In certain embodiments, about 0.02% to about 0.1% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein).

[0134] In certain embodiments, a composition (e.g., a composition provided herein) comprises a solvent, such as mannitol. In certain embodiments, about 0.001% to about 5% (w / w) of a composition provided herein is mannitol. In some embodiments, about 0.01% to about 1% (w / w) of a composition provided herein is mannitol. In certain embodiments, about 0.02% to about 0.1% (w / w) of a composition provided herein is mannitol. In some embodiments, about 0.1% to about 1% (w / w) of a composition provided herein is mannitol. In specific embodiments, about 0.02% to about 0.1% (w / w) of a composition provided herein is mannitol. In yet more specific embodiments, about 0.03% to about 0.04% (w / w) of a composition provided herein is mannitol. In still more specific embodiments, about 0.05% to about 0.07% (w / w) of a composition provided herein is mannitol. In yet more specific embodiments, about 0.035% (w / w) of a composition provided herein is mannitol. In still more specific embodiments, about 0.3% (w / w) of a composition provided herein is mannitol. In yet more specific embodiments, about 1% (w / w) of a composition provided herein is mannitol.

[0135] In some embodiments, a composition provided herein comprises mannitol at about 0.001% to about 5% (w / w) of the composition. In certain embodiments, a composition provided herein comprises mannitol at about 0.001% to about 0.01%, about 0.001% to about 0.02%, about 0.001% to about 0.03%, about 0.001% to about 0.035%, about 0.001% to about 0.04%, about 0.001% to about 0.06%, about 0.001% to about 0.1%, about 0.001% to about 0.5%, about 0.001% to about 1%, about 0.001% to about 2.5%, about 0.001% to about 5%, about 0.01% to about 0.02%, about 0.01% to about 0.03%, about 0.01% to about 0.035%, about 0.01% to about 0.04%, about 0.01% to about 0.06%, about 0.01% to about 0.1%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.02% to about 0.03%, about 0.02% to about 0.035%, about 0.02% to about 0.04%, about 0.02% to about 0.06%, about 0.02% to about 0.1%, about 0.02% to about 0.5%, about 0.02% to about 1%, about 0.02% to about 2.5%, about 0.02% to about 5%, about 0.03% to about 0.035%, about 0.03% to about 0.04%, about 0.03% to about 0.06%, about 0.03% to about 0.1%, about 0.03% to about 0.5%, about 0.03% to about 1%,WSGR Docket No.63230-728.601 about 0.03% to about 2.5%, about 0.03% to about 5%, about 0.035% to about 0.04%, about 0.035% to about 0.06%, about 0.035% to about 0.1%, about 0.035% to about 0.5%, about 0.035% to about 1%, about 0.035% to about 2.5%, about 0.035% to about 5%, about 0.04% to about 0.06%, about 0.04% to about 0.1%, about 0.04% to about 0.5%, about 0.04% to about 1%, about 0.04% to about 2.5%, about 0.04% to about 5%, about 0.06% to about 0.1%, about 0.06% to about 0.5%, about 0.06% to about 1%, about 0.06% to about 2.5%, about 0.06% to about 5%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.5% to about 1%, about 0.5% to about 2.5%, about 0.5% to about 5%, about 1% to about 2.5%, about 1% to about 5%, or about 2.5% to about 5% (w / w). In some embodiments, about 0.001%, about 0.01%, about 0.02%, about 0.03%, about 0.035%, about 0.04%, about 0.06%, about 0.1%, about 0.5%, about 1%, about 2.5%, or about 5% (w / w) of the composition. In some embodiments, at least about 0.001%, about 0.01%, about 0.02%, about 0.03%, about 0.035%, about 0.04%, about 0.06%, about 0.1%, about 0.5%, about 1%, or about 2.5% (w / w) of a composition provided herein is mannitol. In some embodiments, not more than about 0.01%, about 0.02%, about 0.03%, about 0.035%, about 0.04%, about 0.06%, about 0.1%, about 0.5%, about 1%, about 2.5%, or about 5% (w / w) of a composition provided herein is mannitol.

[0136] In certain embodiments, a composition (e.g., a composition provided herein) comprises a solvent (e.g., a solvent provided herein). In certain embodiments, about 1% to about 60% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein). In some embodiments, about 5% to about 40% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein). In certain embodiments, about 10% to about 30% (w / w) of a composition provided herein is a solvent (e.g., a solvent provided herein). In some embodiments, the odor binding protein does not substantially denature or unfold in the presence of alcohol, such as denatured ethanol. In some instances, the odor binding protein does not substantially denature or unfold in the presence of about 20% (w / w), about 30% (w / w), about 40% (w / w), about 50% (w / w), or about 60% (w / w) of alcohol, such as denatured ethanol. In some embodiments, the solvent improves a dry time of the composition.

[0137] In certain embodiments, a composition (e.g., a composition provided herein) comprises a solvent, such as an (e.g., denatured) alcohol. In certain embodiments, about 1% to about 60% (w / w) of a composition provided herein is denatured ethanol. In some embodiments, about 5% to about 40% (w / w) of a composition provided herein is denatured ethanol. In certain embodiments, about 10% to about 30% (w / w) of a composition provided herein is denatured ethanol. In some embodiments, about 10% to about 20% (w / w) of a composition provided herein is denatured ethanol. In some embodiments, about 25% to about 50% (w / w) of a composition provided herein is denatured ethanol. In some embodiments, about 1% to about 20% (w / w) of a composition provided herein is denatured ethanol. In specific embodiments, about 20% to about 25% (w / w) of a compositionWSGR Docket No.63230-728.601 provided herein is denatured ethanol. In yet more specific embodiments, about 45% to about 50% (w / w) of a composition provided herein is denatured ethanol. In still more specific embodiments, about 5% to about 15% (w / w) of a composition provided herein is denatured ethanol. In yet more specific embodiments, about 22% (w / w) of a composition provided herein is denatured ethanol. In still more specific embodiments, about 35% (w / w) of a composition provided herein is denatured ethanol. In yet more specific embodiments, about 5% (w / w) of a composition provided herein is denatured ethanol.

[0138] In some embodiments, a composition provided herein is denatured ethanol at about 1% to about 60% (w / w) of the composition. In some embodiments, about 1% to about 5%, about 1% to about 10%, about 1% to about 15%, about 1% to about 20%, about 1% to about 21%, about 1% to about 22%, about 1% to about 25%, about 1% to about 30%, about 1% to about 40%, about 1% to about 50%, about 1% to about 60%, about 5% to about 10%, about 5% to about 15%, about 5% to about 20%, about 5% to about 21%, about 5% to about 22%, about 5% to about 25%, about 5% to about 30%, about 5% to about 40%, about 5% to about 50%, about 5% to about 60%, about 10% to about 15%, about 10% to about 20%, about 10% to about 21%, about 10% to about 22%, about 10% to about 25%, about 10% to about 30%, about 10% to about 40%, about 10% to about 50%, about 10% to about 60%, about 15% to about 20%, about 15% to about 21%, about 15% to about 22%, about 15% to about 25%, about 15% to about 30%, about 15% to about 40%, about 15% to about 50%, about 15% to about 60%, about 20% to about 21%, about 20% to about 22%, about 20% to about 25%, about 20% to about 30%, about 20% to about 40%, about 20% to about 50%, about 20% to about 60%, about 21% to about 22%, about 21% to about 25%, about 21% to about 30%, about 21% to about 40%, about 21% to about 50%, about 21% to about 60%, about 22% to about 25%, about 22% to about 30%, about 22% to about 40%, about 22% to about 50%, about 22% to about 60%, about 25% to about 30%, about 25% to about 40%, about 25% to about 50%, about 25% to about 60%, about 30% to about 40%, about 30% to about 50%, about 30% to about 60%, about 40% to about 50%, about 40% to about 60%, or about 50% to about 60% of a composition provided herein is denatured ethanol. In some embodiments, about 1%, about 5%, about 10%, about 15%, about 20%, about 21%, about 22%, about 25%, about 30%, about 40%, about 50%, or about 60% of a composition provided herein is denatured ethanol. In some embodiments, at least about 1%, about 5%, about 10%, about 15%, about 20%, about 21%, about 22%, about 25%, about 30%, about 40%, or about 50% (w / w) of a composition provided herein is denatured ethanol. In some embodiments, not more than about 5%, about 10%, about 15%, about 20%, about 21%, about 22%, about 25%, about 30%, about 40%, about 50%, or about 60% (w / w) of a composition provided herein is denatured ethanol.WSGR Docket No.63230-728.601

[0139] In certain instances, the addition of denatured alcohol to a composition provided herein is useful for dissolving additional components of compositions provided herein (e.g., without interfering with active ingredients (e.g., an odor binding protein provided herein) of the same).

[0140] In some aspects, compositions (e.g., a composition provided herein) comprise a humectant. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) a humectant. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one humectant, two humectants, three humectants, four humectants, five humectants, or more. In certain instances, a humectant (e.g., a humectant provided herein) is useful for moisturizing (such as moisturizing the hair and / or scalp of an individual). Humectants are added to compositions (e.g., a composition provided herein, such as a non-aerosol formulation) for such purposes.

[0141] In some embodiments, the humectants comprise any suitable humectant. In certain embodiments, a humectant comprises a hyaluronate, glycol, sorbitol, sugar (e.g., glucose), carbocyclic sugar, (e.g., sugar) alcohol, or a combination of two or more thereof. In some embodiments, the humectant comprises 1,2,6 hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyldiol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, hydrolyzed hyaluronic acid, sodium hyaluronate, inositol, erythritol, capryl glycol, acetamidoethoxyethanol, or a combination of two or more thereof.

[0142] In specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises glycerin. In yet more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises sorbitol. In still more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises potassium PCA. In yet more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises mannitol. In yet more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises propylene glycol. In still more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises hexanetriol. In yet more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises sodium hyaluronate. In still more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises hydrolyzed hyaluronic acid. In yet more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises hydrogenated honey. In still more specific embodiments, a humectant in a composition (e.g., a composition provided herein) comprises acetamidoethoxyethanol.

[0143] In certain embodiments, humectants (e.g., total humectant) comprise about 0.01% to about 5% by weight (w / w) of a composition (e.g., a composition provided herein). In someWSGR Docket No.63230-728.601 embodiments, humectants comprise about 0.1% to about 2% (w / w) of the composition. In certain embodiments, humectants comprise about 0.25% to about 1% (w / w) of the composition.

[0144] In certain embodiments, a composition provided herein comprises a humectant (e.g., a humectant provided herein). In some embodiments, about 0.01% to about 10% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein). In certain embodiments, about 0.05% to about 5% of a composition provided herein is a humectant (e.g., a humectant provided herein). In certain embodiments, about 0.1% to about 1% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein).

[0145] In certain embodiments, a composition provided herein comprises a humectant such as glycerin. In some embodiments, about 0.01% to about 10% (w / w) of a composition provided herein is glycerin. In certain embodiments, about 0.05% to about 5% of a composition provided herein is glycerin. In certain embodiments, about 0.1% to about 1% (w / w) of a composition provided herein is glycerin. In some embodiments, about 1% to about 5% (w / w) of a composition provided herein is glycerin. In specific embodiments, about 0.1% to about 0.2% (w / w) of a composition provided herein is glycerin. In yet more specific embodiments, about 0.3% to about 0.5% (w / w) of a composition provided herein is glycerin. In still more specific embodiments, about 1.4% to about 2.5% (w / w) of a composition provided herein is glycerin. In yet more specific embodiments, about 0.4% (w / w) of a composition provided herein is glycerin. In still more specific embodiments, about 1% (w / w) of a composition provided herein is glycerin. In yet more specific embodiments, about 5% (w / w) of a composition provided herein is glycerin.

[0146] In some embodiments, a composition provided herein comprises glycerin at about 0.01% to about 10% (w / w) of the composition. In some embodiments, a composition provided herein comprises glycerin at about 0.01% to about 0.1%, about 0.01% to about 0.2%, about 0.01% to about 0.3%, about 0.01% to about 0.4%, about 0.01% to about 0.5%, about 0.01% to about 0.6%, about 0.01% to about 1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.01% to about 7.5%, about 0.01% to about 10%, about 0.1% to about 0.2%, about 0.1% to about 0.3%, about 0.1% to about 0.4%, about 0.1% to about 0.5%, about 0.1% to about 0.6%, about 0.1% to about 1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.1% to about 7.5%, about 0.1% to about 10%, about 0.2% to about 0.3%, about 0.2% to about 0.4%, about 0.2% to about 0.5%, about 0.2% to about 0.6%, about 0.2% to about 1%, about 0.2% to about 2.5%, about 0.2% to about 5%, about 0.2% to about 7.5%, about 0.2% to about 10%, about 0.3% to about 0.4%, about 0.3% to about 0.5%, about 0.3% to about 0.6%, about 0.3% to about 1%, about 0.3% to about 2.5%, about 0.3% to about 5%, about 0.3% to about 7.5%, about 0.3% to about 10%, about 0.4% to about 0.5%, about 0.4% to about 0.6%, about 0.4% to about 1%, about 0.4% to about 2.5%, about 0.4% to about 5%, about 0.4% to about 7.5%, about 0.4% to about 10%, about 0.5% to about 0.6%, about 0.5% to about 1%, about 0.5% to about 2.5%, about 0.5% to about 5%, about 0.5% to about 7.5%, about 0.5% toWSGR Docket No.63230-728.601 about 10%, about 0.6% to about 1%, about 0.6% to about 2.5%, about 0.6% to about 5%, about 0.6% to about 7.5%, about 0.6% to about 10%, about 1% to about 2.5%, about 1% to about 5%, about 1% to about 7.5%, about 1% to about 10%, about 2.5% to about 5%, about 2.5% to about 7.5%, about 2.5% to about 10%, about 5% to about 7.5%, about 5% to about 10%, or about 7.5% to about 10% (w / w). In some embodiments, about 0.01%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 1%, about 2.5%, about 5%, about 7.5%, or about 10%. In some embodiments, a composition provided herein comprises glycerin at least about 0.01%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 1%, about 2.5%, about 5%, or about 7.5% (w / w) of the composition. In some embodiments, not more than about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 1%, about 2.5%, about 5%, about 7.5%, or about 10% (w / w) of a composition provided herein is glycerin.

[0147] In certain embodiments, a composition (e.g., a composition provided herein) comprises a humectant (e.g., a humectant provided herein). In certain embodiments, about 0.001% to about 5% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein). In some embodiments, about 0.01% to about 1% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein). In certain embodiments, about 0.02% to about 0.1% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein).

[0148] In certain embodiments, a composition (e.g., a composition provided herein) comprises a humectant, such as mannitol. In certain embodiments, about 0.001% to about 5% (w / w) of a composition provided herein is mannitol. In some embodiments, about 0.01% to about 1% (w / w) of a composition provided herein is mannitol. In certain embodiments, about 0.02% to about 0.1% (w / w) of a composition provided herein is mannitol. In some embodiments, about 0.1% to about 1% (w / w) of a composition provided herein is mannitol. In specific embodiments, about 0.02% to about 0.1% (w / w) of a composition provided herein is mannitol. In yet more specific embodiments, about 0.03% to about 0.04% (w / w) of a composition provided herein is mannitol. In still more specific embodiments, about 0.05% to about 0.07% (w / w) of a composition provided herein is mannitol. In yet more specific embodiments, about 0.035% (w / w) of a composition provided herein is mannitol. In still more specific embodiments, about 0.3% (w / w) of a composition provided herein is mannitol. In yet more specific embodiments, about 1% (w / w) of a composition provided herein is mannitol.

[0149] In some embodiments, a composition provided herein comprises mannitol at about 0.001% to about 5% (w / w) of the composition. In certain embodiments, a composition provided herein comprises mannitol at about 0.001% to about 0.01%, about 0.001% to about 0.02%, about 0.001% to about 0.03%, about 0.001% to about 0.035%, about 0.001% to about 0.04%, about 0.001% to about 0.06%, about 0.001% to about 0.1%, about 0.001% to about 0.5%, about 0.001% to about 1%, about 0.001% to about 2.5%, about 0.001% to about 5%, about 0.01% to about 0.02%, about 0.01% to about 0.03%, about 0.01% to about 0.035%, about 0.01% to about 0.04%, aboutWSGR Docket No.63230-728.601 0.01% to about 0.06%, about 0.01% to about 0.1%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.02% to about 0.03%, about 0.02% to about 0.035%, about 0.02% to about 0.04%, about 0.02% to about 0.06%, about 0.02% to about 0.1%, about 0.02% to about 0.5%, about 0.02% to about 1%, about 0.02% to about 2.5%, about 0.02% to about 5%, about 0.03% to about 0.035%, about 0.03% to about 0.04%, about 0.03% to about 0.06%, about 0.03% to about 0.1%, about 0.03% to about 0.5%, about 0.03% to about 1%, about 0.03% to about 2.5%, about 0.03% to about 5%, about 0.035% to about 0.04%, about 0.035% to about 0.06%, about 0.035% to about 0.1%, about 0.035% to about 0.5%, about 0.035% to about 1%, about 0.035% to about 2.5%, about 0.035% to about 5%, about 0.04% to about 0.06%, about 0.04% to about 0.1%, about 0.04% to about 0.5%, about 0.04% to about 1%, about 0.04% to about 2.5%, about 0.04% to about 5%, about 0.06% to about 0.1%, about 0.06% to about 0.5%, about 0.06% to about 1%, about 0.06% to about 2.5%, about 0.06% to about 5%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.5% to about 1%, about 0.5% to about 2.5%, about 0.5% to about 5%, about 1% to about 2.5%, about 1% to about 5%, or about 2.5% to about 5% (w / w). In some embodiments, about 0.001%, about 0.01%, about 0.02%, about 0.03%, about 0.035%, about 0.04%, about 0.06%, about 0.1%, about 0.5%, about 1%, about 2.5%, or about 5% (w / w) of the composition. In some embodiments, at least about 0.001%, about 0.01%, about 0.02%, about 0.03%, about 0.035%, about 0.04%, about 0.06%, about 0.1%, about 0.5%, about 1%, or about 2.5% (w / w) of a composition provided herein is mannitol. In some embodiments, not more than about 0.01%, about 0.02%, about 0.03%, about 0.035%, about 0.04%, about 0.06%, about 0.1%, about 0.5%, about 1%, about 2.5%, or about 5% (w / w) of a composition provided herein is mannitol.

[0150] In certain embodiments, a composition (e.g., a composition provided herein) comprises a humectant (e.g., a humectant provided herein). In certain embodiments, about 0.0001% to about 2% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein). In some embodiments, about 0.0005% to about 1% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein). In certain embodiments, about 0.001% to about 0.01% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein).

[0151] In certain embodiments, a composition (e.g., a composition provided herein) comprises a humectant, such as sodium hyaluronate. In certain embodiments, about 0.0001% to about 2% (w / w) of a composition provided herein is sodium hyaluronate. In some embodiments, about 0.0005% to about 1% (w / w) of a composition provided herein is sodium hyaluronate. In certain embodiments, about 0.001% to about 0.001% (w / w) of a composition provided herein is sodium hyaluronate. In specific embodiments, about 0.1% to about 0.5% (w / w) of a composition provided herein is sodium hyaluronate. In yet more specific embodiments, about 0.001% to about 0.003% (w / w) of a composition provided herein is sodium hyaluronate. In still more specific embodiments, aboutWSGR Docket No.63230-728.601 0.001% to about 0.002% (w / w) of a composition provided herein is sodium hyaluronate. In yet more specific embodiments, about 0.005% to about 0.009% (w / w) of a composition provided herein is sodium hyaluronate. In still more specific embodiments, about 1.0% to about 1.5% (w / w) of a composition provided herein is sodium hyaluronate. In yet more specific embodiments, about 0.001% of a composition provided herein is sodium hyaluronate. In still more specific embodiments, about 1.0% (w / w) of a composition provided herein is sodium hyaluronate. In yet more specific embodiments, about 0.0015% to about 0.002% (w / w) of a composition provided herein is sodium hyaluronate. In still more specific embodiments, about 0.0018% (w / w) of a composition provided herein is sodium hyaluronate.

[0152] In some embodiments, a composition provided herein comprises sodium hyaluronate at about 0.0001% to about 2% (w / w) of the composition. In some embodiments, about 0.0001% to about 0.0003%, about 0.0001% to about 0.0006%, about 0.0001% to about 0.0009%, about 0.0001% to about 0.0018%, about 0.0001% to about 0.0025%, about 0.0001% to about 0.01%, about 0.0001% to about 0.05%, about 0.0001% to about 0.1%, about 0.0001% to about 0.5%, about 0.0001% to about 1%, about 0.0001% to about 2%, about 0.0003% to about 0.0006%, about 0.0003% to about 0.0009%, about 0.0003% to about 0.0018%, about 0.0003% to about 0.0025%, about 0.0003% to about 0.01%, about 0.0003% to about 0.05%, about 0.0003% to about 0.1%, about 0.0003% to about 0.5%, about 0.0003% to about 1%, about 0.0003% to about 2%, about 0.0006% to about 0.0009%, about 0.0006% to about 0.0018%, about 0.0006% to about 0.0025%, about 0.0006% to about 0.01%, about 0.0006% to about 0.05%, about 0.0006% to about 0.1%, about 0.0006% to about 0.5%, about 0.0006% to about 1%, about 0.0006% to about 2%, about 0.0009% to about 0.0018%, about 0.0009% to about 0.0025%, about 0.0009% to about 0.01%, about 0.0009% to about 0.05%, about 0.0009% to about 0.1%, about 0.0009% to about 0.5%, about 0.0009% to about 1%, about 0.0009% to about 2%, about 0.0018% to about 0.0025%, about 0.0018% to about 0.01%, about 0.0018% to about 0.05%, about 0.0018% to about 0.1%, about 0.0018% to about 0.5%, about 0.0018% to about 1%, about 0.0018% to about 2%, about 0.0025% to about 0.01%, about 0.0025% to about 0.05%, about 0.0025% to about 0.1%, about 0.0025% to about 0.5%, about 0.0025% to about 1%, about 0.0025% to about 2%, about 0.01% to about 0.05%, about 0.01% to about 0.1%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2%, about 0.05% to about 0.1%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.05% to about 2%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2%, about 0.5% to about 1%, about 0.5% to about 2%, or about 1% to about 2% (w / w) of a composition provided herein is sodium hyaluronate. In some embodiments, about 0.0001%, about 0.0003%, about 0.0006%, about 0.0009%, about 0.0018%, about 0.0025%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, or about 2% (w / w) of a composition provided herein is sodium hyaluronate. In some embodiments, at least about 0.0001%, about 0.0003%, about 0.0006%, about 0.0009%, about 0.0018%, about 0.0025%,WSGR Docket No.63230-728.601 about 0.01%, about 0.05%, about 0.1%, about 0.5%, or about 1% (w / w) of a composition provided herein is sodium hyaluronate. In some embodiments, not more than about 0.0003%, about 0.0006%, about 0.0009%, about 0.0018%, about 0.0025%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, or about 2% (w / w) of a composition provided herein is sodium hyaluronate.

[0153] In some embodiments, the sodium hyaluronate in the composition comprises a molecular weight (kDa). In some embodiments, the sodium hyaluronate comprises a molecular weight of about 100 kDa to about 2,000 kDa, about 100 kDa to about 1,800 kDa, about 100 kDa to about 1,600 kDa, about 100 kDa to about 1,400 kDa, about 100 kDa to about 1,200 kDa, about 100 kDa to about 1,000 kDa, about 100 kDa to about 800 kDa, about 100 kDa to about 600 kDa, about 100 kDa to about 400 kDa, about 100 kDa to about 200 kDa, about 200 kDa to about 2,000 kDa, about 200 kDa to about 1,800 kDa, about 200 kDa to about 1,600 kDa, about 200 kDa to about 1,400 kDa, about 200 kDa to about 1,200 kDa, about 200 kDa to about 1,000 kDa, about 200 kDa to about 800 kDa, about 200 kDa to about 600 kDa, about 200 kDa to about 400 kDa, about 500 kDa to about 2,000 kDa, about 500 kDa to about 1,800 kDa, about 500 kDa to about 1,600 kDa, about 500 kDa to about 1,400 kDa, about 500 kDa to about 1,200 kDa, about 500 kDa to about 1,000 kDa, about 500 kDa to about 800 kDa, about 500 kDa to about 600 kDa, about 100 kDa to about 2,000 kDa, about 200 kDa to about 1,800 kDa, about 300 kDa to about 1,600 kDa, about 400 kDa to about 1,400 kDa, about 500 kDa to about 1,200 kDa, about 600 kDa to about 1,000 kDa, or about 700 kDa to about 800 kDa.

[0154] In some instances, the addition of sodium hyaluronate to a composition provided herein is useful for maintaining moisture in the hair of an individual. In certain instances, sodium hyaluronate is useful for exfoliating the scalp and strengthening the hair of an individual.

[0155] In certain embodiments, a composition (e.g., a composition provided herein) comprises a humectant (e.g., a humectant provided herein). In certain embodiments, about 0.0001% to about 2% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein). In some embodiments, about 0.0005% to about 1% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein). In certain embodiments, about 0.001% to about 0.1% (w / w) of a composition provided herein is a humectant (e.g., a humectant provided herein).

[0156] In certain embodiments, a composition (e.g., a composition provided herein) comprises a humectant, such as (e.g., hydrolyzed) hyaluronic acid. In certain embodiments, about 0.0001% to about 2% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In some embodiments, about 0.0005% to about 1% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In certain embodiments, about 0.001% to about 0.1% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In certain embodiments, about 0.001% to about 0.01% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In some embodiments, about 0.1% to about 0.5% (w / w) of a composition provided herein isWSGR Docket No.63230-728.601 (e.g., hydrolyzed) hyaluronic acid. In some embodiments, about 0.001% to about 0.004% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In some embodiments, about 1.0% to about 1.5% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In specific embodiments, about 0.005% to about 0.008% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In yet more specific embodiments, about 0.005% to about 0.008% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In still more specific embodiments, about 0.006% to about 0.007% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In yet more specific embodiments, about 0.01% to about 0.05% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In still more specific embodiments, about 0.007% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In yet more specific embodiments, about 1.5% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In still more specific embodiments, about 0.0004% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid.

[0157] In some embodiments, a composition provided herein comprises (e.g., hydrolyzed) hyaluronic acid at about 0.0001% to about 2% (w / w) of the composition. In some embodiments, about 0.0001% to about 0.0005%, about 0.0001% to about 0.001%, about 0.0001% to about 0.003%, about 0.0001% to about 0.0064%, about 0.0001% to about 0.0085%, about 0.0001% to about 0.01%, about 0.0001% to about 0.05%, about 0.0001% to about 0.1%, about 0.0001% to about 0.5%, about 0.0001% to about 1%, about 0.0001% to about 2%, about 0.0005% to about 0.001%, about 0.0005% to about 0.003%, about 0.0005% to about 0.0064%, about 0.0005% to about 0.0085%, about 0.0005% to about 0.01%, about 0.0005% to about 0.05%, about 0.0005% to about 0.1%, about 0.0005% to about 0.5%, about 0.0005% to about 1%, about 0.0005% to about 2%, about 0.001% to about 0.003%, about 0.001% to about 0.0064%, about 0.001% to about 0.0085%, about 0.001% to about 0.01%, about 0.001% to about 0.05%, about 0.001% to about 0.1%, about 0.001% to about 0.5%, about 0.001% to about 1%, about 0.001% to about 2%, about 0.003% to about 0.0064%, about 0.003% to about 0.0085%, about 0.003% to about 0.01%, about 0.003% to about 0.05%, about 0.003% to about 0.1%, about 0.003% to about 0.5%, about 0.003% to about 1%, about 0.003% to about 2%, about 0.0064% to about 0.0085%, about 0.0064% to about 0.01%, about 0.0064% to about 0.05%, about 0.0064% to about 0.1%, about 0.0064% to about 0.5%, about 0.0064% to about 1%, about 0.0064% to about 2%, about 0.0085% to about 0.01%, about 0.0085% to about 0.05%, about 0.0085% to about 0.1%, about 0.0085% to about 0.5%, about 0.0085% to about 1%, about 0.0085% to about 2%, about 0.01% to about 0.05%, about 0.01% to about 0.1%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2%, about 0.05% to about 0.1%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.05% to about 2%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2%, about 0.5% to about 1%, about 0.5% to about 2%, or about 1% to about 2% (w / w) of a composition provided herein is (e.g., hydrolyzed)WSGR Docket No.63230-728.601 hyaluronic acid. In some embodiments, about 0.0001%, about 0.0005%, about 0.001%, about 0.003%, about 0.0064%, about 0.0085%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, or about 2% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid. In some embodiments, at least about 0.0001%, about 0.0005%, about 0.001%, about 0.003%, about 0.0064%, about 0.0085%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, or about 1% (w / w) of a composition provided herein is (e.g., hydrolyzed hyaluronic acid). In some embodiments, not more than about 0.0005%, about 0.001%, about 0.003%, about 0.0064%, about 0.0085%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, or about 2% (w / w) of a composition provided herein is (e.g., hydrolyzed) hyaluronic acid.

[0158] In some instances, the addition of hyaluronic acid to a composition provided herein is useful for smoothing or reducing frizz in the hair of an individual. In certain instances, addition of hyaluronic acid to a composition provided herein is useful for soothing skin on the scalp of an individual

[0159] In some aspects, compositions (e.g., a composition provided herein) comprise a rheology modifying agent. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) comprise a rheology modifying agent. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one rheology modifying agent, two rheology modifying agents, three rheology modifying agents, four rheology modifying agents, five rheology modifying agents, or more. In certain embodiments, a rheology modifying agent (e.g., a rheology modifying agent provided herein) is useful for providing a stable suspension of a composition (e.g., a composition provided herein, such as a non-aerosol formulation). In certain instances, a rheology modifying agent is used as a emulsifying agent or gelling agent (e.g., such as by keeping oil and water phases together through fluctuations in temperature). In certain instances, addition of a rheology modifying agent to a composition (e.g., a non-aerosol formulation) is useful for forming oil-in-water emulsions.

[0160] In some embodiments, a rheology modifying agent (e.g., a rheology modifying agent provided herein) comprises any suitable rheology modifying agent (such as a hydrocolloid). In some embodiments a rheology modifying agent comprises a naturally derived polymer. In certain embodiments, a rheology modifying agent comprises a hydrocolloid (e.g., gellan gum), aqueous natural polymer (e.g., carboxymethyl cellulose), sugar (e.g., pectin), and the like. In certain embodiments, a rheology modifying agent comprises pectin, gellan gum, carrageen, glycerin, agar, xanthan gum, pullulan, algin, tetragonoloba (guar) gum, sclerotium gum, acacia Senegal gum, cellulose, cellulose gum, carboxymethylcellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, lauryl polyglucose, or a combination of two or more thereof. In specificWSGR Docket No.63230-728.601 embodiments, a rheology modifying agent in a composition (e.g., a composition provided herein) comprises agar. In yet more specific embodiments, a rheology modifying agent in a composition (e.g., a composition provided herein) comprises gellan gum. In still more specific embodiments, a rheology modifying agent in a composition (e.g., a composition provided herein) comprises carboxymethyl cellulose.

[0161] In certain embodiments, a composition (e.g., a composition provided herein) comprises a rheology modifying agent (e.g., a rheology modifying agent provided herein). In certain embodiments, about 0.005% to about 10% (w / w) of a composition provided herein is a rheology modifying agent (e.g., a rheology modifying agent provided herein). In some embodiments, about 0.01% to about 2% (w / w) of a composition provided herein is a rheology modifying agent (e.g., a rheology modifying agent provided herein). In certain embodiments, about 0.05% to about 0.5% (w / w) of a composition provided herein is a rheology modifying agent (e.g., a rheology modifying agent provided herein).

[0162] In certain embodiments, a composition (e.g., a composition provided herein) comprises a rheology modifying agent, such as gellan gum. In certain embodiments, about 0.005% to about 10% (w / w) of a composition provided herein is gellan gum. In some embodiments, about 0.01% to about 2% (w / w) of a composition provided herein is gellan gum. In certain embodiments, about 0.05% to about 0.5% (w / w) of a composition provided herein is gellan gum. In specific embodiments, about 0.5% to about 5% (w / w) of a composition provided herein is gellan gum. In yet more specific embodiments, about 0.05% to about 0.15% (w / w) of a composition provided herein is gellan gum. In still more specific embodiments, about 1% to about 2% (w / w) of a composition provided herein is gellan gum. In yet more specific embodiments, about 0.1% of a composition provided herein is gellan gum. In still more specific embodiments, about 0.06% (w / w) of a composition provided herein is gellan gum. In yet more specific embodiments, about 5% to about 7% (w / w) of a composition provided herein is gellan gum. In still more specific embodiments, about 0.3% (w / w) of a composition provided herein is gellan gum. In yet more specific embodiments, about 2% to about 3.5% (w / w) of a composition provided herein is gellan gum.

[0163] In some embodiments, a composition provided herein comprises gellan gum at about 0.01% to about 10% (w / w) of the composition. In some embodiments, about 0.01% to about 0.05%, about 0.01% to about 0.08%, about 0.01% to about 0.1%, about 0.01% to about 0.12%, about 0.01% to about 0.15%, about 0.01% to about 0.25%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.01% to about 10%, about 0.05% to about 0.08%, about 0.05% to about 0.1%, about 0.05% to about 0.12%, about 0.05% to about 0.15%, about 0.05% to about 0.25%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.05% to about 2.5%, about 0.05% to about 5%, about 0.05% to about 10%, about 0.08% to about 0.1%, about 0.08% to about 0.12%, about 0.08% to about 0.15%, about 0.08% to about 0.25%,WSGR Docket No.63230-728.601 about 0.08% to about 0.5%, about 0.08% to about 1%, about 0.08% to about 2.5%, about 0.08% to about 5%, about 0.08% to about 10%, about 0.1% to about 0.12%, about 0.1% to about 0.15%, about 0.1% to about 0.25%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.1% to about 10%, about 0.12% to about 0.15%, about 0.12% to about 0.25%, about 0.12% to about 0.5%, aboutto about 1%, about 0.12% to about 2.5%, about 0.12% to about 5%, about 0.12% to about 10%, about 0.15% to about 0.25%, about 0.15% to about 0.5%, about 0.15% to about 1%, about 0.15% to about 2.5%, about 0.15% to about 5%, about 0.15% to about 10%, about 0.25% to about 0.5%, about 0.25% to about 1%, about 0.25% to about 2.5%, about 0.25% to about 5%, about 0.25% to about 10%, about 0.5% to about 1%, about 0.5% to about 2.5%, about 0.5% to about 5%, about 0.5% to about 10%, about 1% to about 2.5%, about 1% to about 5%, about 1% to about 10%, about 2.5% to about 5%, about 2.5% to about 10%, or about 5% to about 10% (w / w) of a composition provided herein is gellan gum. In some embodiments, about 0.01%, about 0.05%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, about 5%, or about 10% (w / w) of a composition provided herein is gellan gum. In some embodiments, at least about 0.01%, about 0.05%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, or about 5% (w / w) of a composition provided herein is gellan gum. In some embodiments, not more than about 0.05%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, about 5%, or about 10% (w / w) of a composition provided herein is gellan gum.

[0164] In certain instances, the addition of gellan gum is useful for suspending components of a composition, such as a non-aerosol, hydroalcoholic formulation.

[0165] In some aspects, compositions (e.g., a composition provided herein) comprise a stabilizing agent. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) comprise a stabilizing agent. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one stabilizing agent, two stabilizing agents, three stabilizing agents, four stabilizing agents, five stabilizing agents, or more. In certain embodiments, a stabilizing agent (e.g., a stabilizing agent provided herein) is useful for maintaining the function and activity of additional agents of a composition (e.g., a composition provided herein, such as a non- aerosol formulation). In some embodiments, when a rheology modifier is present, the rheology modifier creates a shear-thinning structure gel that suspends powders and prevents compaction. In some embodiments, the shear-thinning structure gel sets and is maintained by the cations of the stabilizing agent, such as NaCl or MgCl2.

[0166] In some embodiments, a stabilizing agent comprises a salt, sulfate, or the like. In some embodiments, a stabilizing agent comprises calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, or a combination of two or more thereof. In specific embodiments, a stabilizing agent in a composition (e.g., a compositionWSGR Docket No.63230-728.601 provided herein) comprises calcium chloride. In yet more specific embodiments, a stabilizing agent in a composition (e.g., a composition provided herein) comprises sodium chloride. In still more specific embodiments, a stabilizing agent in a composition (e.g., a composition provided herein) comprises potassium glycol sulfate.

[0167] In certain embodiments, a composition (e.g., a composition provided herein) comprises a stabilizing agent (e.g., a stabilizing agent provided herein). In certain embodiments, about 0.005% to about 10% (w / w) of a composition provided herein is a stabilizing agent (e.g., a stabilizing agent provided herein). In some embodiments, about 0.01% to about 2% (w / w) of a composition provided herein is a stabilizing agent (e.g., a stabilizing agent provided herein). In certain embodiments, about 0.05% to about 0.5% (w / w) of a composition provided herein is a stabilizing agent (e.g., a stabilizing agent provided herein).

[0168] In certain embodiments, a composition (e.g., a composition provided herein) comprises a stabilizing agent, such as sodium chloride. In certain embodiments, about 0.005% to about 10% (w / w) of a composition provided herein is sodium chloride. In some embodiments, about 0.01% to about 2% (w / w) of a composition provided herein is sodium chloride. In certain embodiments, about 0.05% to about 0.5% (w / w) of a composition provided herein is sodium chloride. In specific embodiments, about 0.5% to about 5% (w / w) of a composition provided herein is sodium chloride. In yet more specific embodiments, about 0.05% to about 0.15% (w / w) of a composition provided herein is sodium chloride. In still more specific embodiments, about 1% to about 2% (w / w) of a composition provided herein is sodium chloride. In yet more specific embodiments, about 0.1% of a composition provided herein is sodium chloride. In still more specific embodiments, about 0.06% (w / w) of a composition provided herein is sodium chloride. In yet more specific embodiments, about 5% to about 7% (w / w) of a composition provided herein is sodium chloride. In still more specific embodiments, about 0.3% (w / w) of a composition provided herein is sodium chloride. In yet more specific embodiments, about 2% to about 3.5% (w / w) of a composition provided herein is sodium chloride.

[0169] In some embodiments, a composition provided herein comprises sodium chloride at about 0.001% to about 10% of the composition. In some embodiments, about 0.001% to about 0.01%, about 0.001% to about 0.08%, about 0.001% to about 0.1%, about 0.001% to about 0.12%, about 0.001% to about 0.15%, about 0.001% to about 0.25%, about 0.001% to about 0.5%, about 0.001% to about 1%, about 0.001% to about 2.5%, about 0.001% to about 5%, about 0.001% to about 10%, about 0.01% to about 0.08%, about 0.01% to about 0.1%, about 0.01% to about 0.12%, about 0.01% to about 0.15%, about 0.01% to about 0.25%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.01% to about 10%, about 0.08% to about 0.1%, about 0.08% to about 0.12%, about 0.08% to about 0.15%, about 0.08% to about 0.25%, about 0.08% to about 0.5%, about 0.08% to about 1%, about 0.08% to about 2.5%,WSGR Docket No.63230-728.601 about 0.08% to about 5%, about 0.08% to about 10%, about 0.1% to about 0.12%, about 0.1% to about 0.15%, about 0.1% to about 0.25%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.1% to about 10%, about 0.12% to about 0.15%, about 0.12% to about 0.25%, about 0.12% to about 0.5%, about 0.12% to about 1%, about 0.12% to about 2.5%, aboutto about 5%, about 0.12% to about 10%, about 0.15% to about 0.25%, about 0.15% to about 0.5%, about 0.15% to about 1%, about 0.15% to about 2.5%, about 0.15% to about 5%, about 0.15% to about 10%, about 0.25% to about 0.5%, about 0.25% to about 1%, about 0.25% to about 2.5%, about 0.25% to about 5%, about 0.25% to about 10%, about 0.5% to about 1%, about 0.5% to about 2.5%, about 0.5% to about 5%, about 0.5% to about 10%, about 1% to about 2.5%, about 1% to about 5%, about 1% to about 10%, about 2.5% to about 5%, about 2.5% to about 10%, or about 5% to about 10% (w / w) of a composition provided herein is sodium chloride. In some embodiments, about 0.001%, about 0.01%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, about 5%, or about 10% (w / w) of a composition provided herein is sodium chloride. In some embodiments, at least about 0.001%, about 0.01%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, or about 5% (w / w) of a composition provided herein is sodium chloride. In some embodiments, not more than about 0.01%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, about 5%, or about 10% (w / w) of a composition provided herein is sodium chloride.

[0170] In some aspects, compositions (e.g., a composition provided herein) comprise a chelating agent. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) comprise a chelating agent. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one chelating agent, two chelating agents, three chelating agents, four chelating agents, five chelating agents, or more. In certain instances, a chelating agent (e.g., a chelating agent provided herein) is useful for binding to metals and preventing metal- catalyzed reactions in a composition (e.g., a composition provided herein, such as a non-aerosol formulation) thereby stabilizing such compositions. In certain instances, chelating agents are useful for removing mineral deposits and impurities (such as from the scalp and / or hair of an individual).

[0171] In certain embodiments, a chelating agent can be any suitable chelating agent (e.g., EDTA, sodium phytate, and the like). In some embodiments, a chelating agent comprises EDTA, sodium phytate, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, caprylhydroxamic acid, or a combination of two or more thereof. In specific embodiments, a chelating agent in a composition (e.g., a composition provided herein) comprises EDTA. In yet more specific embodiments, a chelating agent in a composition (e.g., a composition provided herein) comprises sodium phytate. In still more specific embodiments, a chelating agent in a composition (e.g., a composition provided herein) comprises sodium gluconate.WSGR Docket No.63230-728.601

[0172] In certain embodiments, a composition (e.g., a composition provided herein) comprises a chelating agent (e.g., a chelating agent provided herein). In certain embodiments, about 0.005% to about 10% (w / w) of a composition provided herein is a chelating agent (e.g., a chelating agent provided herein). In some embodiments, about 0.01% to about 2% (w / w) of a composition provided herein is a chelating agent (e.g., a chelating agent provided herein). In certain embodiments, about 0.05% to about 0.5% (w / w) of a composition provided herein is a chelating agent (e.g., a chelating agent provided herein).

[0173] In certain embodiments, a composition (e.g., a composition provided herein) comprises a chelating agent, such as sodium phytate. In certain embodiments, about 0.005% to about 10% (w / w) of a composition provided herein is sodium phytate. In some embodiments, about 0.01% to about 2% (w / w) of a composition provided herein is sodium phytate. In certain embodiments, about 0.05% to about 0.5% (w / w) of a composition provided herein is sodium phytate. In specific embodiments, about 0.5% to about 5% (w / w) of a composition provided herein is sodium phytate. In yet more specific embodiments, about 0.05% to about 0.15% (w / w) of a composition provided herein is sodium phytate. In still more specific embodiments, about 1% to about 2% (w / w) of a composition provided herein is sodium phytate. In yet more specific embodiments, about 0.1% of a composition provided herein is sodium phytate. In still more specific embodiments, about 0.06% (w / w) of a composition provided herein is sodium phytate. In yet more specific embodiments, about 5% to about 7% (w / w) of a composition provided herein is sodium phytate. In still more specific embodiments, about 0.3% (w / w) of a composition provided herein is sodium phytate. In yet more specific embodiments, about 2% to about 3.5% (w / w) of a composition provided herein is sodium phytate.

[0174] In some embodiments, a composition provided herein comprises sodium phytate at about 0.01% to about 10% (w / w) of the composition. In some embodiments, about 0.01% to about 0.05%, about 0.01% to about 0.08%, about 0.01% to about 0.1%, about 0.01% to about 0.12%, about 0.01% to about 0.15%, about 0.01% to about 0.25%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.01% to about 10%, about 0.05% to about 0.08%, about 0.05% to about 0.1%, about 0.05% to about 0.12%, about 0.05% to about 0.15%, about 0.05% to about 0.25%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.05% to about 2.5%, about 0.05% to about 5%, about 0.05% to about 10%, about 0.08% to about 0.1%, about 0.08% to about 0.12%, about 0.08% to about 0.15%, about 0.08% to about 0.25%, about 0.08% to about 0.5%, about 0.08% to about 1%, about 0.08% to about 2.5%, about 0.08% to about 5%, about 0.08% to about 10%, about 0.1% to about 0.12%, about 0.1% to about 0.15%, about 0.1% to about 0.25%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.1% to about 10%, about 0.12% to about 0.15%, about 0.12% to about 0.25%, about 0.12% to about 0.5%, about 0.12% to about 1%, about 0.12% to about 2.5%,WSGR Docket No.63230-728.601 about 0.12% to about 5%, about 0.12% to about 10%, about 0.15% to about 0.25%, about 0.15% to about 0.5%, about 0.15% to about 1%, about 0.15% to about 2.5%, about 0.15% to about 5%, about 0.15% to about 10%, about 0.25% to about 0.5%, about 0.25% to about 1%, about 0.25% to about 2.5%, about 0.25% to about 5%, about 0.25% to about 10%, about 0.5% to about 1%, about 0.5% to about 2.5%, about 0.5% to about 5%, about 0.5% to about 10%, about 1% to about 2.5%, about 1% to about 5%, about 1% to about 10%, about 2.5% to about 5%, about 2.5% to about 10%, or about 5% to about 10% (w / w) of a composition provided herein is sodium phytate. In some embodiments, about 0.01%, about 0.05%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, about 5%, or about 10% (w / w) of a composition provided herein is sodium phytate. In some embodiments, at least about 0.01%, about 0.05%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, or about 5% (w / w) of a composition provided herein is sodium phytate. In some embodiments, not more than about 0.05%, about 0.08%, about 0.1%, about 0.12%, about 0.15%, about 0.25%, about 0.5%, about 1%, about 2.5%, about 5%, or about 10% (w / w) of a composition provided herein is sodium phytate.

[0175] In some aspects, compositions (e.g., a composition provided herein) comprise a preservative. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) comprise a preservative. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one preservative, two preservatives, three preservatives, four preservatives, five preservatives, or more. In some instances, preservatives (e.g., a preservative provided herein) are useful for extending the duration of efficacy of (e.g., active components, such as an odor binding protein provided herein) of a composition (e.g., a composition provided herein, such as a non-aerosol formulation). In certain instances, addition of preservatives to a composition provided herein (e.g., a non-aerosol, hydroalcoholic formulation) are useful for inhibiting and / or preventing growth of harmful microorganisms in such compositions.

[0176] In some embodiments, a preservative (e.g., a preservative provided herein) can be any suitable preservative (e.g., used in products fit for human consumption, such as personal care products). In some embodiments, a preservative comprises a alcohol (e.g., benzyl alcohol), paraben, formaldehyde release, carbamate, sorbate, and the like. In certain embodiments, a preservative comprises benzyl alcohol, benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or a combination of two or more thereof. In specific embodiments, a preservative in a composition (e.g., a composition provided herein) comprises potassium sorbate. In yet more specific embodiments, a preservative in a composition (e.g., a composition provided herein) comprises benzyl alcohol. In still more specificWSGR Docket No.63230-728.601 embodiments, a preservative in a composition (e.g., a composition provided herein) comprises phenoxyethanol.

[0177] In certain embodiments, about 0.005% to about 10% (w / w) of a composition provided herein comprises a preservative (e.g., a preservative provided herein). In some embodiments, about .01% to about 5% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In certain embodiments, about 0.5% to about 2% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In specific embodiments, about 0.8% to about 1.2% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In yet more specific embodiments, about 0.9% to about 1.1% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In still more specific embodiments, about 0.95% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In yet more specific embodiments, about 1.5% to about 7.5% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In still more specific embodiments, about 2% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In specific embodiments, the preservative is benzyl alcohol.

[0178] In some embodiments, a composition provided herein comprises a preservative (e.g., a preservative provided herein) at about 0.01% to about 10% (w / w) of the composition. In some embodiments, about 0.01% to about 0.05%, about 0.01% to about 0.1%, about 0.01% to about 0.2%, about 0.01% to about 0.4%, about 0.01% to about 0.7%, about 0.01% to about 0.95%, about 0.01% to about 1.1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.01% to about 7.5%, about 0.01% to about 10%, about 0.05% to about 0.1%, about 0.05% to about 0.2%, about 0.05% to about 0.4%, about 0.05% to about 0.7%, about 0.05% to about 0.95%, about 0.05% to about 1.1%, about 0.05% to about 2.5%, about 0.05% to about 5%, about 0.05% to about 7.5%, about 0.05% to about 10%, about 0.1% to about 0.2%, about 0.1% to about 0.4%, about 0.1% to about 0.7%, about 0.1% to about 0.95%, about 0.1% to about 1.1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.1% to about 7.5%, about 0.1% to about 10%, about 0.2% to about 0.4%, about 0.2% to about 0.7%, about 0.2% to about 0.95%, about 0.2% to about 1.1%, about 0.2% to about 2.5%, about 0.2% to about 5%, about 0.2% to about 7.5%, about 0.2% to about 10%, about 0.4% to about 0.7%, about 0.4% to about 0.95%, about 0.4% to about 1.1%, about 0.4% to about 2.5%, about 0.4% to about 5%, about 0.4% to about 7.5%, about 0.4% to about 10%, about 0.7% to about 0.95%, about 0.7% to about 1.1%, about 0.7% to about 2.5%, about 0.7% to about 5%, about 0.7% to about 7.5%, about 0.7% to about 10%, about 0.95% to about 1.1%, about 0.95% to about 2.5%, about 0.95% to about 5%, about 0.95% to about 7.5%, about 0.95% to about 10%, about 1.1% to about 2.5%, about 1.1% to about 5%, about 1.1% to about 7.5%, about 1.1% to about 10%, about 2.5% to about 5%, about 2.5% to about 7.5%, about 2.5% to about 10%, about 5% to about 7.5%, about 5% to about 10%, or about 7.5% to about 10% (w / w) of a composition provided herein is aWSGR Docket No.63230-728.601 preservative (e.g., a preservative provided herein). In some embodiments, about 0.01%, about 0.05%, about 0.1%, about 0.2%, about 0.4%, about 0.7%, about 0.95%, about 1.1%, about 2.5%, about 5%, about 7.5%, or about 10% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In some embodiments, at least about 0.01%, about 0.05%, about 0.1%, about 0.2%, about 0.4%, about 0.7%, about 0.95%, about 1.1%, about 2.5%, about 5%, or about 7.5% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein). In some embodiments, not more than about 0.05%, about 0.1%, about 0.2%, about 0.4%, about 0.7%, about 0.95%, about 1.1%, about 2.5%, about 5%, about 7.5%, or about 10% (w / w) of a composition provided herein is a preservative (e.g., a preservative provided herein).

[0179] In some aspects, compositions (e.g., a composition provided herein) comprise a fragrance component. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) comprise a fragrance component. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one fragrance component, two fragrance components, three fragrance components, four fragrance components, five fragrance components, or more. In some instances, fragrance components (e.g., a fragrance component provided herein) are provided in a composition (e.g., a composition provided herein, such as a non- aerosol, hydroalcoholic formulation) to reduce malodor (e.g., of the scalp and hair of an individual). In certain instances, fragrance components are useful additions to compositions provided herein for reduction of malodor (e.g., of an individual)). In some instances, fragrance components of compositions provided herein provide pleasant odors to such compositions.

[0180] In some embodiments, a fragrance component can be any suitable fragrance (e.g., used in personal hygiene products of an individual). In some embodiments, a fragrance component comprises a synthetic or naturally derived fragrance. In certain embodiments, a fragrance component (e.g., a fragrance component provided herein) comprises linalool, hexyl cinnamal, limonene, or benzyl alcohol, and the like. In some embodiments, a fragrance component (e.g., a fragrance component provided herein) comprises linalool, hexyl cinnamal, limonene, or benzyl alcohol, and / or a combination of two or more thereof.

[0181] In certain embodiments, about 0.01% to about 10% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In some embodiments, about 0.05% to about 5% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In certain embodiments, about 0.1% to about 1% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In specific embodiments, about 0.2% to about 0.3% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In yet more specific embodiments, about 0.25% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In still more specificWSGR Docket No.63230-728.601 embodiments, about 0.1% to about 0.3% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In specific embodiments, the fragrance component comprises linalool, hexyl cinnamal, limonene, or benzyl alcohol, or a combination of two or more thereof.

[0182] In some embodiments, a composition provided herein comprises a fragrance component (e.g., a fragrance component provided herein) at about 0.01% to about 10% (w / w) of the composition. In some embodiments, about 0.01% to about 0.05%, about 0.01% to about 0.08%, about 0.01% to about 0.1%, about 0.01% to about 0.2%, about 0.01% to about 0.25%, about 0.01% to about 0.3%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.01% to about 2.5%, about 0.01% to about 5%, about 0.01% to about 10%, about 0.05% to about 0.08%, about 0.05% to about 0.1%, about 0.05% to about 0.2%, about 0.05% to about 0.25%, about 0.05% to about 0.3%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.05% to about 2.5%, about 0.05% to about 5%, about 0.05% to about 10%, about 0.08% to about 0.1%, about 0.08% to about 0.2%, about 0.08% to about 0.25%, about 0.08% to about 0.3%, about 0.08% to about 0.5%, about 0.08% to about 1%, about 0.08% to about 2.5%, about 0.08% to about 5%, about 0.08% to about 10%, about 0.1% to about 0.2%, about 0.1% to about 0.25%, about 0.1% to about 0.3%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2.5%, about 0.1% to about 5%, about 0.1% to about 10%, about 0.2% to about 0.25%, about 0.2% to about 0.3%, about 0.2% to about 0.5%, about 0.2% to about 1%, about 0.2% to about 2.5%, about 0.2% to about 5%, about 0.2% to about 10%, about 0.25% to about 0.3%, about 0.25% to about 0.5%, about 0.25% to about 1%, about 0.25% to about 2.5%, about 0.25% to about 5%, about 0.25% to about 10%, about 0.3% to about 0.5%, about 0.3% to about 1%, about 0.3% to about 2.5%, about 0.3% to about 5%, about 0.3% to about 10%, about 0.5% to about 1%, about 0.5% to about 2.5%, about 0.5% to about 5%, about 0.5% to about 10%, about 1% to about 2.5%, about 1% to about 5%, about 1% to about 10%, about 2.5% to about 5%, about 2.5% to about 10%, or about 5% to about 10% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In some embodiments, about 0.01%, about 0.05%, about 0.08%, about 0.1%, about 0.2%, about 0.25%, about 0.3%, about 0.5%, about 1%, about 2.5%, about 5%, or about 10% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In some embodiments, at least about 0.01%, about 0.05%, about 0.08%, about 0.1%, about 0.2%, about 0.25%, about 0.3%, about 0.5%, about 1%, about 2.5%, or about 5% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In some embodiments, not more than about 0.05%, about 0.08%, about 0.1%, about 0.2%, about 0.25%, about 0.3%, about 0.5%, about 1%, about 2.5%, about 5%, or about 10% (w / w) of a composition provided herein is a fragrance component (e.g., a fragrance component provided herein). In specific embodiments, the fragranceWSGR Docket No.63230-728.601 component comprises linalool, hexyl cinnamal, limonene, or benzyl alcohol, or a combination of two or more thereof.

[0183] In some aspects, compositions (e.g., a composition provided herein) comprise a buffering agent. In specific embodiments, additional agents of compositions (e.g., a composition provided herein) comprise a buffering agent. In yet more specific embodiments, compositions (e.g., a composition provided herein) comprise one buffering agent, two buffering agents, three buffering agents, four buffering agents, five buffering agents, or more. In some instances, buffering agents (e.g., a buffering agent provided herein) are provided in a composition (e.g., a composition provided herein, such as a non-aerosol, hydroalcoholic formulation) to raise or lower the pH of such composition (or for raising or lowering pH of the scalp or hair of an individual). In certain instances, buffering agents maintain the pH of compositions provided herein.

[0184] In some embodiments, the buffering agent can be any acid or base suitable for use in products fit for human consumption, such as personal care products. In certain embodiments, a buffering agent (e.g., a buffering agent provided herein) comprises weak acids, weak bases, amino acids, weak organic acids, weak organic bases, and the like. In some embodiments, buffering agents (e.g., a buffering agent provided herein) can comprise citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, arginine, tromethamine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. In specific embodiments, a buffering agent in a composition (e.g., a composition provided herein) lactic acid. In yet more specific embodiments, a buffering agent in a composition (e.g., a composition provided herein) comprises citric acid. In still more specific embodiments, a buffering agent in a composition (e.g., a composition provided herein) comprises tromethamine. In yet more specific embodiments, a buffering agent in a composition (e.g., a composition provided herein) comprises arginine. In still more specific embodiments, a buffering agent in a composition (e.g., a composition provided herein) comprises malic acid.

[0185] In certain embodiments, a buffering agent (e.g., total buffering agent) is about 0.001% to about 1% by weight (w / w) of a composition (e.g., a composition provided herein). In some embodiments, a buffering agent is about 0.005% to about 0.5% (w / w) of the composition. In certain embodiments, a buffering agent is about 0.01% to about 0.1% (w / w) of the composition.

[0186] In certain embodiments, about 0.0005% to about 1% (w / w) of a composition provided herein comprises a buffering agent (e.g., a buffering agent provided herein). In some embodiments, about 0.0001% to about 0.5% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In certain embodiments, about 0.0005% to about 0.01% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In specific embodiments, about 0.001% to about 0.002% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In yet more specific embodiments, about 0.0017% to about 0.0019% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agentWSGR Docket No.63230-728.601 provided herein). In still more specific embodiments, about 0.0018% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In yet more specific embodiments, about 0.0005% to about 0.0009% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In still more specific embodiments, about 0.1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In specific embodiments, a buffering agent in a composition (e.g., a composition provided herein) comprises lactic acid.

[0187] In some embodiments, a composition provided herein comprises a buffering agent (e.g., a buffering agent provided herein) at about 0.0001% to about 1% (w / w) of the composition. In some embodiments, about 0.0001% to about 0.0003%, about 0.0001% to about 0.0006%, about 0.0001% to about 0.0009%, about 0.0001% to about 0.0012%, about 0.0001% to about 0.0018%, about 0.0001% to about 0.0025%, about 0.0001% to about 0.05%, about 0.0001% to about 0.1%, about 0.0001% to about 0.25%, about 0.0001% to about 0.5%, about 0.0001% to about 1%, about 0.0003% to about 0.0006%, about 0.0003% to about 0.0009%, about 0.0003% to about 0.0012%, about 0.0003% to about 0.0018%, about 0.0003% to about 0.0025%, about 0.0003% to about 0.05%, about 0.0003% to about 0.1%, about 0.0003% to about 0.25%, about 0.0003% to about 0.5%, about 0.0003% to about 1%, about 0.0006% to about 0.0009%, about 0.0006% to about 0.0012%, about 0.0006% to about 0.0018%, about 0.0006% to about 0.0025%, about 0.0006% to about 0.05%, about 0.0006% to about 0.1%, about 0.0006% to about 0.25%, about 0.0006% to about 0.5%, about 0.0006% to about 1%, about 0.0009% to about 0.0012%, about 0.0009% to about 0.0018%, about 0.0009% to about 0.0025%, about 0.0009% to about 0.05%, about 0.0009% to about 0.1%, about 0.0009% to about 0.25%, about 0.0009% to about 0.5%, about 0.0009% to about 1%, about 0.0012% to about 0.0018%, about 0.0012% to about 0.0025%, about 0.0012% to about 0.05%, about 0.0012% to about 0.1%, about 0.0012% to about 0.25%, about 0.0012% to about 0.5%, about 0.0012% to about 1%, about 0.0018% to about 0.0025%, about 0.0018% to about 0.05%, about 0.0018% to about 0.1%, about 0.0018% to about 0.25%, about 0.0018% to about 0.5%, about 0.0018% to about 1%, about 0.0025% to about 0.05%, about 0.0025% to about 0.1%, about 0.0025% to about 0.25%, about 0.0025% to about 0.5%, about 0.0025% to about 1%, about 0.05% to about 0.1%, about 0.05% to about 0.25%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.1% to about 0.25%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.25% to about 0.5%, about 0.25% to about 1%, or about 0.5% to about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, about 0.0001%, about 0.0003%, about 0.0006%, about 0.0009%, about 0.0012%, about 0.0018%, about 0.0025%, about 0.05%, about 0.1%, about 0.25%, about 0.5%, or about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, at least about 0.0001%, about 0.0003%, about 0.0006%, about 0.0009%, about 0.0012%, about 0.0018%, aboutWSGR Docket No.63230-728.601 0.0025%, about 0.05%, about 0.1%, about 0.25%, or about 0.5% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, not more than about 0.0003%, about 0.0006%, about 0.0009%, about 0.0012%, about 0.0018%, about 0.0025%, about 0.05%, about 0.1%, about 0.25%, about 0.5%, or about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein).

[0188] In certain embodiments, about 0.001% to about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, about 0.005% to about 0.5% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In certain embodiments, about 0.01% to about 0.1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In specific embodiments, about 0.04% to about 0.06% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In yet more specific embodiments, about 0.045% to about 0.055% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In still more specific embodiments, about 0.0515% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In yet more specific embodiments, about 0.0005% to about 0.0007% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In still more specific embodiments, about 0.1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In specific embodiments, a buffering agent in a composition (e.g., a composition provided herein) citric acid.

[0189] In some embodiments, a composition provided herein comprises a buffering agent (e.g., a buffering agent provided herein) at about 0.0001% to about 1% (w / w) of the composition. In some embodiments, about 0.0001% to about 0.0003%, about 0.0001% to about 0.0006%, about 0.0001% to about 0.0009%, about 0.0001% to about 0.0012%, about 0.0001% to about 0.0018%, about 0.0001% to about 0.0025%, about 0.0001% to about 0.0515%, about 0.0001% to about 0.1%, about 0.0001% to about 0.25%, about 0.0001% to about 0.5%, about 0.0001% to about 1%, about 0.0003% to about 0.0006%, about 0.0003% to about 0.0009%, about 0.0003% to about 0.0012%, about 0.0003% to about 0.0018%, about 0.0003% to about 0.0025%, about 0.0003% to about 0.0515%, about 0.0003% to about 0.1%, about 0.0003% to about 0.25%, about 0.0003% to about 0.5%, about 0.0003% to about 1%, about 0.0006% to about 0.0009%, about 0.0006% to about 0.0012%, about 0.0006% to about 0.0018%, about 0.0006% to about 0.0025%, about 0.0006% to about 0.0515%, about 0.0006% to about 0.1%, about 0.0006% to about 0.25%, about 0.0006% to about 0.5%, about 0.0006% to about 1%, about 0.0009% to about 0.0012%, about 0.0009% to about 0.0018%, about 0.0009% to about 0.0025%, about 0.0009% to about 0.0515%, about 0.0009% to about 0.1%, about 0.0009% to about 0.25%, about 0.0009% to about 0.5%, about 0.0009% to about 1%, about 0.0012% to about 0.0018%, about 0.0012% to about 0.0025%, about 0.0012% to about 0.0515%, aboutWSGR Docket No.63230-728.601 0.0012% to about 0.1%, about 0.0012% to about 0.25%, about 0.0012% to about 0.5%, about 0.0012% to about 1%, about 0.0018% to about 0.0025%, about 0.0018% to about 0.0515%, about 0.0018% to about 0.1%, about 0.0018% to about 0.25%, about 0.0018% to about 0.5%, about 0.0018% to about 1%, about 0.0025% to about 0.0515%, about 0.0025% to about 0.1%, about 0.0025% to about 0.25%, about 0.0025% to about 0.5%, about 0.0025% to about 1%, about 0.0515% to about 0.1%, about 0.0515% to about 0.25%, about 0.0515% to about 0.5%, about 0.0515% to about 1%, about 0.1% to about 0.25%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.25% to about 0.5%, about 0.25% to about 1%, or about 0.5% to about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, about 0.0001%, about 0.0003%, about 0.0006%, about 0.0009%, about 0.0012%, about 0.0018%, about 0.0025%, about 0.0515%, about 0.1%, about 0.25%, about 0.5%, or about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, at least about 0.0001%, about 0.0003%, about 0.0006%, about 0.0009%, about 0.0012%, about 0.0018%, about 0.0025%, about 0.0515%, about 0.1%, about 0.25%, or about 0.5% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, not more than about 0.0003%, about 0.0006%, about 0.0009%, about 0.0012%, about 0.0018%, about 0.0025%, about 0.0515%, about 0.1%, about 0.25%, about 0.5%, or about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein).

[0190] In certain embodiments, about 0.0001% to about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, the buffering agent comprises tromethamine, or Tris. In some embodiments, about 0.0005% to about 0.5% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In certain embodiments, about 0.001% to about 0.05% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein).

[0191] In specific embodiments, about 0.003% to about 0.005% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In still more specific embodiments, about 0.004% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In yet more specific embodiments, about 0.0001% to about 0.0003% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In still more specific embodiments, about 0.6% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In specific embodiments, the buffering agent in a composition (e.g., a composition provided herein) comprises tromethamine.

[0192] In some embodiments, a composition provided herein comprises a buffering agent (e.g., a buffering agent provided herein) at about 0.0001% to about 1% of the composition. In some embodiments, about 0.0001% to about 0.0003%, about 0.0001% to about 0.0009%, about 0.0001%WSGR Docket No.63230-728.601 to about 0.0025%, about 0.0001% to about 0.004%, about 0.0001% to about 0.006%, about 0.0001% to about 0.01%, about 0.0001% to about 0.05%, about 0.0001% to about 0.1%, about 0.0001% to about 0.25%, about 0.0001% to about 0.5%, about 0.0001% to about 1%, about 0.0003% to about 0.0009%, about 0.0003% to about 0.0025%, about 0.0003% to about 0.004%, about 0.0003% to about 0.006%, about 0.0003% to about 0.01%, about 0.0003% to about 0.05%, about 0.0003% to about 0.1%, about 0.0003% to about 0.25%, about 0.0003% to about 0.5%, about 0.0003% to about 1%, about 0.0009% to about 0.0025%, about 0.0009% to about 0.004%, about 0.0009% to about 0.006%, about 0.0009% to about 0.01%, about 0.0009% to about 0.05%, about 0.0009% to about 0.1%, about 0.0009% to about 0.25%, about 0.0009% to about 0.5%, about 0.0009% to about 1%, about 0.0025% to about 0.004%, about 0.0025% to about 0.006%, about 0.0025% to about 0.01%, about 0.0025% to about 0.05%, about 0.0025% to about 0.1%, about 0.0025% to about 0.25%, about 0.0025% to about 0.5%, about 0.0025% to about 1%, about 0.004% to about 0.006%, about 0.004% to about 0.01%, about 0.004% to about 0.05%, about 0.004% to about 0.1%, about 0.004% to about 0.25%, about 0.004% to about 0.5%, about 0.004% to about 1%, about 0.006% to about 0.01%, about 0.006% to about 0.05%, about 0.006% to about 0.1%, about 0.006% to about 0.25%, about 0.006% to about 0.5%, about 0.006% to about 1%, about 0.01% to about 0.05%, about 0.01% to about 0.1%, about 0.01% to about 0.25%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.05% to about 0.1%, about 0.05% to about 0.25%, about 0.05% to about 0.5%, about 0.05% to about 1%, about 0.1% to about 0.25%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.25% to about 0.5%, about 0.25% to about 1%, or about 0.5% to about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, about 0.0001%, about 0.0003%, about 0.0009%, about 0.0025%, about 0.004%, about 0.006%, about 0.01%, about 0.05%, about 0.1%, about 0.25%, about 0.5%, or about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, at least about 0.0001%, about 0.0003%, about 0.0009%, about 0.0025%, about 0.004%, about 0.006%, about 0.01%, about 0.05%, about 0.1%, about 0.25%, or about 0.5% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, not more than about 0.0003%, about 0.0009%, about 0.0025%, about 0.004%, about 0.006%, about 0.01%, about 0.05%, about 0.1%, about 0.25%, about 0.5%, or about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein).

[0193] In certain embodiments, about 0.00001% to about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, about 0.00005% to about 0.5% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In certain embodiments, about 0.000075% to about 0.005% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In specific embodiments, about 0.00009% to about 0.00011% (w / w) of a composition provided hereinWSGR Docket No.63230-728.601 is a buffering agent (e.g., a buffering agent provided herein). In still more specific embodiments, about 0.0001 % (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In yet more specific embodiments, about 0.0005% to about 0.001% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In still more specific embodiments, about 0.2% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In specific embodiments, a buffering agent in a composition (e.g., a composition provided herein) is arginine.

[0194] In some embodiments, a composition provided herein comprises a buffering agent (e.g., a buffering agent provided herein) at about 0.00001% to about 1% (w / w) of a total weight of the composition. In some embodiments, about 0.00001% to about 0.00002%, about 0.00001% to about 0.00004%, about 0.00001% to about 0.00006%, about 0.00001% to about 0.00008%, about 0.00001% to about 0.0001%, about 0.00001% to about 0.0005%, about 0.00001% to about 0.001%, about 0.00001% to about 0.01%, about 0.00001% to about 0.1%, about 0.00001% to about 0.5%, about 0.00001% to about 1%, about 0.00002% to about 0.00004%, about 0.00002% to about 0.00006%, about 0.00002% to about 0.00008%, about 0.00002% to about 0.0001%, about 0.00002% to about 0.0005%, about 0.00002% to about 0.001%, about 0.00002% to about 0.01%, about 0.00002% to about 0.1%, about 0.00002% to about 0.5%, about 0.00002% to about 1%, about 0.00004% to about 0.00006%, about 0.00004% to about 0.00008%, about 0.00004% to about 0.0001%, about 0.00004% to about 0.0005%, about 0.00004% to about 0.001%, about 0.00004% to about 0.01%, about 0.00004% to about 0.1%, about 0.00004% to about 0.5%, about 0.00004% to about 1%, about 0.00006% to about 0.00008%, about 0.00006% to about 0.0001%, about 0.00006% to about 0.0005%, about 0.00006% to about 0.001%, about 0.00006% to about 0.01%, about 0.00006% to about 0.1%, about 0.00006% to about 0.5%, about 0.00006% to about 1%, about 0.00008% to about 0.0001%, about 0.00008% to about 0.0005%, about 0.00008% to about 0.001%, about 0.00008% to about 0.01%, about 0.00008% to about 0.1%, about 0.00008% to about 0.5%, about 0.00008% to about 1%, about 0.0001% to about 0.0005%, about 0.0001% to about 0.001%, about 0.0001% to about 0.01%, about 0.0001% to about 0.1%, about 0.0001% to about 0.5%, about 0.0001% to about 1%, about 0.0005% to about 0.001%, about 0.0005% to about 0.01%, about 0.0005% to about 0.1%, about 0.0005% to about 0.5%, about 0.0005% to about 1%, about 0.001% to about 0.01%, about 0.001% to about 0.1%, about 0.001% to about 0.5%, about 0.001% to about 1%, about 0.01% to about 0.1%, about 0.01% to about 0.5%, about 0.01% to about 1%, about 0.1% to about 0.5%, about 0.1% to about 1%, or about 0.5% to about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, about 0.00001%, about 0.00002%, about 0.00004%, about 0.00006%, about 0.00008%, about 0.0001%, about 0.0005%, about 0.001%, about 0.01%, about 0.1%, about 0.5%, or about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In someWSGR Docket No.63230-728.601 embodiments, at least about 0.00001%, about 0.00002%, about 0.00004%, about 0.00006%, about 0.00008%, about 0.0001%, about 0.0005%, about 0.001%, about 0.01%, about 0.1%, or about 0.5% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein). In some embodiments, not more than about 0.00002%, about 0.00004%, about 0.00006%, about 0.00008%, about 0.0001%, about 0.0005%, about 0.001%, about 0.01%, about 0.1%, about 0.5%, or about 1% (w / w) of a composition provided herein is a buffering agent (e.g., a buffering agent provided herein).

[0195] In certain embodiments, a composition (e.g., a composition provided herein) comprises an odor binding protein and an absorbing agent. In specific embodiments, the composition comprises an odor binding protein, an absorbing agent, and one or more of: a solvent, humectant, rheology modifying agent, chelating agent, sebum regulating agent, fragrance component, buffering agent. In yet more specific embodiments, the composition comprises an odor binding protein, absorbing agent, humectant, rheology modifying agent, chelating agent, sebum regulating agent, fragrance component, buffering agent, and solvent. In still more specific embodiments, the composition comprises an odor binding protein, absorbing agent, sebum regulating agent, buffering agent, and solvent. In yet more specific embodiments, the composition comprises an odor binding protein, absorbing agent, humectant, rheology modifying agent, buffering agent, and solvent. In still more specific embodiments, the composition comprises an odor binding protein, absorbing agent, rheology modifying agent, chelating agent, sebum regulating agent, and solvent. In some embodiments, the composition is a hair or scalp composition. In some embodiments, the composition described herein maintains or increases a hair property to where applied, e.g., hair and / or skin of individuals as compared to a hair property of hair not applied with the composition. In some embodiments, the composition described herein increases a hair property to where applied, e.g., hair and / or skin of individuals, when compared to no application of the composition. In some embodiments, the composition described herein increases a hair property to where applied, e.g., hair and / or skin of individuals, when compared to a baseline measurement. In some embodiments, the composition described herein maintains a hair property to where applied, e.g., hair and / or skin of individuals, when compared to no application of the composition. In some embodiments, the composition described herein maintains a hair property to where applied, e.g., hair and / or skin of individuals, when compared to a baseline measurement. In some embodiments, the composition described herein is applied to hair prior to heat application. Table 1 depicts non-limiting examples of compositions comprising an odor binding protein, absorbing agent, and one or more additional agents. Table 1: non-limiting examples of compositions comprising odor binding protein and absorbing agent Formulation IWSGR Docket No.63230-728.601WSGR Docket No.63230-728.601

[0196] In certain embodiments, a composition (e.g., a composition provided herein) comprises an odor binding protein and a sebum regulating agent. In specific embodiments, the composition comprises an odor binding protein, a sebum regulating agent, and one or more of: a solvent, humectant, rheology modifying agent, chelating agent, absorbing agent, fragrance component, buffering agent. In yet more specific embodiments, the composition comprises an odor binding protein, sebum regulating agent, humectant, rheology modifying agent, chelating agent, absorbing regulating agent, fragrance component, buffering agent, and solvent. In still more specific embodiments, the composition comprises an odor binding protein, sebum regulating agent, buffering agent, and solvent. In yet more specific embodiments, the composition comprises an odor binding protein, sebum regulating agent, humectant, rheology modifying agent, buffering agent, and solvent. In still more specific embodiments, the composition comprises an odor binding protein, sebum regulating agent, absorbing agent, rheology modifying agent, chelating agent, and solvent. In someWSGR Docket No.63230-728.601 embodiments, the composition is a hair or scalp composition. In some embodiments, the composition described herein maintains or increases a hair property to where applied, e.g., hair and / or skin of individuals as compared to a hair property of hair not applied with the composition. In some embodiments, the composition described herein increases a hair property where applied, e.g., hair and / or skin of individuals, when compared to no application of the composition. In some embodiments, the composition described herein increases a hair property where applied, e.g., hair and / or skin of individuals, when compared to a baseline measurement. In some embodiments, the composition described herein maintains a hair property to where applied, e.g., hair and / or skin of individuals, when compared to no application of the composition. In some embodiments, the composition described herein maintains a hair property to where applied, e.g., hair and / or skin of individuals, when compared to a baseline measurement. In some embodiments, the composition described herein is applied to hair prior to heat application. Table 2 depicts non-limiting examples of compositions comprising an odor binding protein, sebum regulating agent, and one or more additional agents. Table 2: non-limiting examples of compositions comprising odor binding protein and sebum regulating agentWSGR Docket No.63230-728.601WSGR Docket No.63230-728.601

[0197] In another aspect, the present disclosure provides a method for reducing malodor of a hair and / or scalp of an individual, where the method comprising administering an effective amount of the composition described herein to the hair and / or scalp of the individual.

[0198] In one aspect, the present disclosure provides a method for reducing sebum in a hair and / or scalp of an individual, the method comprising administering an effective amount of the composition described herein to the hair and / or scalp of the individual.

[0199] In another aspect, the present disclosure provides a method for reducing sebum on a hair and / or scalp of an individual, where the method comprising administering an effective amount of a composition comprising an odor binding protein to the hair and scalp of the individual. In some instances, the odor binding protein comprises a sequence at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% identical to any one of SEQ ID NOS: 1-340. In some instances, the odor binding protein comprises a sequence at least about 80% identical to any one of SEQ ID NOS: 1-340. In some instances, the composition further comprises an absorbing agent. In some instances, the composition further comprises a sebum reducing agent.

[0200] In some instances, skin surface levels of sebum of area where applied, e.g., the hair and scalp, are reduced compared to a baseline measurement for about 24 to about 72 hours or more after administration of the composition. In some instances, sebum reduction is measured by a Sebumeter.

[0201] In some instances, when measured immediately after administration compared to a baseline measurement, sebum is reduced about 1 to about 20 g / cm2. In some instances, when measured immediately after administration compared to a baseline measurement, sebum is reduced about 5 to about 15 g / cm2. In some instances, when measured immediately after administration compared to a baseline measurement, sebum is reduced by about 10 g / cm2.

[0202] In some instances, when measured immediately after administration compared to a baseline measurement, the sebum is reduced by about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, or about 100%. In some instances, when measure immediately after administration compared to a baseline measurement, the sebum isWSGR Docket No.63230-728.601 reduced by at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100%. In some instances, when measure immediately after administration compared to a baseline measurement, the sebum is reduced by at most 10%, at most 20%, at most 30%, at most 40%, at most 50%, at most 60%, at most 70%, at most 80%, at most 90%, or at most 100%. In some instances, when measure immediately after administration compared to a baseline measurement, the sebum is reduced by between 10% to 100%, between 20% to 100%, between 30% to 100%, between 40% to 100%, between 50% to 100%, between 60% to 100%, between 70% to 100%, between 80% to 100%, or between 90% to 100%.

[0203] In some instances, when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 19 g / cm2. In some instances, when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced about 4 to about 14 g / cm2. In some instances, when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced by about 9 g / cm2.

[0204] In some instances, when measured about 12 hours after administration compared to a baseline measurement, the sebum is reduced by about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, or about 100%. In some instances, when measured about 12 hours after administration compared to a baseline measurement, the sebum is reduced by at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100%. In some instances, when measured about 12 hours after administration compared to a baseline measurement, the sebum is reduced by at most 10%, at most 20%, at most 30%, at most 40%, at most 50%, at most 60%, at most 70%, at most 80%, at most 90%, or at most 100%. In some instances, when measured about 12 hours after administration compared to a baseline measurement, the sebum is reduced by between 10% to 100%, between 20% to 100%, between 30% to 100%, between 40% to 100%, between 50% to 100%, between 60% to 100%, between 70% to 100%, between 80% to 100%, or between 90% to 100%.

[0205] In some instances, when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 17 g / cm2. In some instances, when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced about 3 to about 12 g / cm2. In some instances, when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced by about 7 g / cm2.

[0206] In some instances, when measured about 24 hours after administration compared to a baseline measurement, the sebum is reduced by about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, or about 100%. In some instances, when measured about 24 hours after administration compared to a baseline measurement, the sebum is reduced by at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100%. In some instances, when measured about 24 hoursWSGR Docket No.63230-728.601 after administration compared to a baseline measurement, the sebum is reduced by at most 10%, at most 20%, at most 30%, at most 40%, at most 50%, at most 60%, at most 70%, at most 80%, at most 90%, or at most 100%. In some instances, when measured about 24 hours after administration compared to a baseline measurement, the sebum is reduced by between 10% to 100%, between 20% to 100%, between 30% to 100%, between 40% to 100%, between 50% to 100%, between 60% to 100%, between 70% to 100%, between 80% to 100%, or between 90% to 100%.

[0207] In some instances, when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 15 g / cm2. In some instances, when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced about 2 to about 10 g / cm2. In some instances, when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced by about 5.5 g / cm2.

[0208] In some instances, when measured about 48 hours after administration compared to a baseline measurement, the sebum is reduced by about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, or about 100%. In some instances, when measured about 48 hours after administration compared to a baseline measurement, the sebum is reduced by at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100%. In some instances, when measured about 48 hours after administration compared to a baseline measurement, the sebum is reduced by at most 10%, at most 20%, at most 30%, at most 40%, at most 50%, at most 60%, at most 70%, at most 80%, at most 90%, or at most 100%. In some instances, when measured about 48 hours after administration compared to a baseline measurement, the sebum is reduced by between 10% to 100%, between 20% to 100%, between 30% to 100%, between 40% to 100%, between 50% to 100%, between 60% to 100%, between 70% to 100%, between 80% to 100%, or between 90% to 100%.

[0209] In some instances, when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 8 g / cm2. In some instances, when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced about 2 to about 6 g / cm2. In some instances, when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced by about 4 g / cm2.

[0210] In some instances, when measured about 72 hours after administration compared to a baseline measurement, the sebum is reduced by about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, or about 100%. In some instances, when measured about 72 hours after administration compared to a baseline measurement, the sebum is reduced by at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100%. In some instances, when measured about 72 hours after administration compared to a baseline measurement, the sebum is reduced by at most 10%, at most 20%, at most 30%, at most 40%, at most 50%, at most 60%, at most 70%, at most 80%, at mostWSGR Docket No.63230-728.601 90%, or at most 100%. In some instances, when measured about 72 hours after administration compared to a baseline measurement, the sebum is reduced by between 10% to 100%, between 20% to 100%, between 30% to 100%, between 40% to 100%, between 50% to 100%, between 60% to 100%, between 70% to 100%, between 80% to 100%, or between 90% to 100%.

[0211] In another aspect, the present disclosure provides a method for reducing malodor on a hair and / or scalp of an individual, the method comprising administering an effective amount of a composition comprising an odor binding protein to the hair and scalp of the individual, wherein the odor binding protein comprises a sequence at least about 80%, at least about 85%, at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% identical to any one of SEQ ID NOS: 1-340. In another aspect, the present disclosure provides a method for reducing malodor on a hair and / or scalp of an individual, the method comprising administering an effective amount of a composition comprising an odor binding protein to the hair and scalp of the individual, wherein the odor binding protein comprises a sequence at least about 80% identical to any one of SEQ ID NOS: 1-340. In some instances, the composition further comprises an absorbing agent. In some instances, the composition further comprises a sebum reducing agent.

[0212] In some instances, malodor levels are reduced compared to a baseline measurement for about 24 to about 72 hours or more after administration of the composition. In some instances, malodor levels are reduced compared to a baseline measurement for about 24 hours, about 48 hours, about 72 hours, or about 96 hours after administration of the composition. In some instances, malodor levels are reduced compared to a baseline measurement for at least 24 hours, at least 48 hours, at least 72 hours, or at least 96 hours after administration of the composition. In some instances, malodor levels are reduced compared to a baseline measurement for at most 24 hours, at most 48 hours, at most 72 hours, or at most 96 hours after administration of the composition. In some instances, malodor levels are reduced compared to a baseline measurement for about 24 hours to about 96 hours, for about 48 hours to about 96 hours, or for about 72 hours to about 96 hours after administration of the composition.

[0213] In some instances, malodor levels are evaluated by a trained odor grader on a scale of 0 to 10. In some instances, when measured immediately after administration compared to a baseline measurement, the malodor levels are reduced about 2 to about 7, about 3 to about 7, about 4 to about 7, about 5 to about 7, or about 6 to about 7 on the scale. In some instances, when measured immediately after administration compared to a baseline measurement, the malodor levels are reduced about 2 to about 7 on the scale. In some instances, when measured immediately after administration compared to a baseline measurement, the malodor levels are reduced about 3 to about 6, about 4 to about 6, or about 5 to about 6 on the scale. In some instances, when measured immediately after administration compared to a baseline measurement, the malodor levels areWSGR Docket No.63230-728.601 reduced about 3 to about 6 on the scale. In some instances, when measured immediately after administration compared to a baseline measurement, the malodor levels are reduced by about 2, about 3, about 4, about 5, about 6, or about 7 on the scale. In some instances, when measured immediately after administration compared to a baseline measurement, the malodor levels are reduced by about 5 on the scale. In some instances, when measured immediately after administration compared to a baseline measurement, the malodor levels are reduced by at least 2, at least 3, at least 4, at least 5, at least 6, or at least 7 on the scale. In some instances, when measured immediately after administration compared to a baseline measurement, the malodor levels are reduced by at most 2, at most 3, at most 4, at most 5, at most 6, or at most 7 on the scale.

[0214] In some instances, when measured about 12 hours after administration compared to a baseline measurement, the malodor levels are reduced about 2 to about 7, about 3 to about 7, about 4 to about 7, about 5 to about 7, or about 6 to about 7 on the scale. In some instances, when measured about 12 hours after administration compared to a baseline measurement, the malodor levels are reduced about 2 to about 7 on the scale. In some instances, when measured about 12 hours after administration compared to a baseline measurement, the malodor levels are reduced about 3 to about 6, about 4 to about 6, or about 5 to about 6 on the scale. In some instances, when measured about 12 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 6 on the scale. In some instances, when measured about 12 hours after administration compared to a baseline measurement, the malodor levels are reduced by about 2, about 3, about 4, about 5, about 6, or about 7 on the scale. In some instances, when measured about 12 hours after administration compared to a baseline measurement, malodor levels are reduced by about 5 on the scale. In some instances, when measured about 12 hours after administration compared to a baseline measurement, the malodor levels are reduced by at least 2, at least 3, at least 4, at least 5, at least 6, or at least 7 on the scale. In some instances, when measured about 12 hours after administration compared to a baseline measurement, the malodor levels are reduced by at most 2, at most 3, at most 4, at most 5, at most 6, or at most 7 on the scale.

[0215] In some instances, when measured about 24 hours after administration compared to a baseline measurement, the malodor levels are reduced about 2 to about 7, about 3 to about 7, about 4 to about 7, about 5 to about 7, or about 6 to about 7 on the scale. In some instances, when measured about 24 hours after administration compared to a baseline measurement, the malodor levels are reduced about 3 to about 6, about 4 to about 6, or about 5 to about 6 on the scale. In some instances, when measured about 24 hours after administration compared to a baseline measurement, the malodor levels are reduced about 2 to about 6 on the scale. In some instances, when measured about 24 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 5 or about 4 to about 5 on the scale. In some instances, when measured about 24 hours after administration compared to a baseline measurement, the malodor levels are reduced by about 2,WSGR Docket No.63230-728.601 about 3, about 4, about 5, about 6, or about 7 on the scale. In some instances, when measured about 24 hours after administration compared to a baseline measurement, malodor levels are reduced by about 4 on the scale. In some instances, when measured about 24 hours after administration compared to a baseline measurement, the malodor levels are reduced by at least 2, at least 3, at least 4, at least 5, at least 6, or at least 7 on the scale. In some instances, when measured about 24 hours after administration compared to a baseline measurement, the malodor levels are reduced by at most 2, at most 3, at most 4, at most 5, at most 6, or at most 7 on the scale.

[0216] In some instances, when measured about 48 hours after administration compared to a baseline measurement, the malodor levels are reduced about 2 to about 5, about 3 to about 5, or about 4 to about 5. In some instances, when measured about 48 hours after administration compared to a baseline measurement, the malodor levels are reduced about 2 to about 5 on the scale. In some instances, when measured about 48 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 4 on the scale. In some instances, when measured about 48 hours after administration compared to a baseline measurement, the malodor levels are reduced by about 2, about 3, about 4, about 5, about 6, or about 7 on the scale. In some instances, when measured about 48 hours after administration compared to a baseline measurement, malodor levels are reduced by about 3.5 on the scale. In some instances, when measured about 48 hours after administration compared to a baseline measurement, the malodor levels are reduced by at least 2, at least 3, at least 4, at least 5, at least 6, or at least 7 on the scale. In some instances, when measured about 48 hours after administration compared to a baseline measurement, the malodor levels are reduced by at most 2, at most 3, at most 4, at most 5, at most 6, or at most 7 on the scale.

[0217] In some instances, when measured about 72 hours after administration compared to a baseline measurement, the malodor levels are reduced about 1 to about 4, about 2 to about 4, about 3 to about 4. In some instances, when measured about 72 hours after administration compared to a baseline measurement, the malodor levels are reduced about 1 to about 4 on the scale. In some instances, when measured about 72 hours after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 3 on the scale. In some instances, when measured about 72 hours after administration compared to a baseline measurement, the malodor levels are reduced by about 1, about 2, about 3, about 4, about 5, or about 6 on the scale. In some instances, when measured about 72 hours after administration compared to a baseline measurement, malodor levels are reduced by about 2.5 on the scale. In some instances, when measured about 72 hours after administration compared to a baseline measurement, the malodor levels are reduced by at least 2, at least 3, at least 4, at least 5, at least 6, or at least 7 on the scale. In some instances, when measured about 72 hours after administration compared to a baseline measurement, the malodor levels are reduced by at most 2, at most 3, at most 4, at most 5, at most 6, or at most 7 on the scale.WSGR Docket No.63230-728.601

[0218] In some embodiments, the composition used in methods described herein maintains or increases a hair property to where applied as compared to the hair property of hair not applied with the composition. In some embodiments, the composition used in methods described herein increases a hair property to where applied as compared to a baseline measurement. In some embodiments, the composition used in methods described herein is applied to hair prior to heat application.

[0219] Throughout this application, various embodiments may be presented in a range of formats. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the disclosure. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, a description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within that range, for example, 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range.

[0220] As used in the specification and claims, the singular forms “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a sample” includes a plurality of samples, including combinations thereof.

[0221] The terms “determining,” “measuring,” “evaluating,” “assessing,” “assaying,” and “analyzing” are often used interchangeably herein to refer to forms of measurement. The terms include determining if an element is present or not (for example, detection). These terms can include quantitative, qualitative, or quantitative and qualitative determinations. Assessing can be relative or absolute. “Detecting the presence of” can include determining the amount of something present in addition to determining whether it is present or absent depending on the context.

[0222] The term “about” or “approximately” as used herein when referring to a measurable value such as an amount or concentration and the like, is meant to encompass variations of 20%, 10%, 5%, 1%, 0.5%, or even 0.1% of the specified amount. For example, “about” can mean plus or minus 10%, per the practice in the art. Alternatively, “about” can mean a range of plus or minus 20%, plus or minus 10%, plus or minus 5%, or plus or minus 1% of a given value. Alternatively, particularly with respect to biological systems or processes, the term can mean within an order of magnitude, up to 5-fold, or up to 2-fold, of a value. Where particular values can be described in the application and claims, unless otherwise stated the term “about” may be assumed to encompass the acceptable error range for the particular value. Also, where ranges, subranges, or both, of values can be provided, the ranges or subranges can include the endpoints of the ranges or subranges. Where “about” is used in relation to a set of values or ranges, “about” may be assumed to distribute to each value listed in the set or range. For example, the phrase “about 5, 10, 15, etc.” is equivalent to “about 5, about 10, about 15, etc.”WSGR Docket No.63230-728.601

[0223] Where values are described as ranges, it may be understood that such disclosure includes the disclosure of all possible sub-ranges within such ranges, as well as specific numerical values that fall within such ranges irrespective of whether a specific numerical value or specific sub-range is expressly stated.

[0224] The terms “comprise,” “have,” and “include” are open-ended linking verbs. Any forms or tenses of one or more of these verbs, such as “comprises,” “comprising,” “has,” “having,” “includes,” and “including,” are also open-ended. For example, any method that “comprises,” “has,” or “includes” one or more steps is not limited to possessing only those one or more steps and also covers other unlisted steps.

[0225] As used herein, the term “mixture” or “mixtures” is meant to include a simple combination of materials and any compounds that may result from their combination.

[0226] As used herein, the term “cosmetically acceptable” refers to those compounds, materials, compositions, and / or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problems or complications commensurate with a reasonable benefit / risk ratio.

[0227] As used herein, the term “percent identity” refers to a comparison between two amino acid sequences. Such comparisons are measured using any number of alignment methods known in the art, including but not limited to global (e.g., Needleman–Wunsch algorithm) or local alignments (e.g., Smith–Waterman, Sellers, or other algorithm). Percent identity refers to the percentage of matching positions of two sequences for a contiguous section of positions, wherein the two sequences are aligned in such a way to maximize matching positions and minimize gaps of non- matching positions. In some instances, alignments are conducted wherein there are no gaps between the two sequences. In some instances, the alignment results in less than 5% gaps, less than 3% gaps, or less than 1% gaps. Additional methods of sequence comparison or alignment are also consistent with the disclosure.

[0228] Percent (%) sequence identity with respect to a reference polypeptide sequence is the percentage of amino acid residues in a candidate sequence that are identical with the amino acid residues in the reference polypeptide sequence, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity, and not considering any conservative substitutions as part of the sequence identity. Alignment for purposes of determining percent amino acid sequence identity can be achieved in various ways that are known for instance, using publicly available computer software such as BLAST, BLAST-2, ALIGN or Megalign (DNASTAR) software. Appropriate parameters for aligning sequences are able to be determined, including algorithms needed to achieve maximal alignment over the full length of the sequences being compared. For purposes herein, however, % amino acid sequence identity values are generated usingWSGR Docket No.63230-728.601 the sequence comparison computer program ALIGN-2. The ALIGN-2 sequence comparison computer program was authored by Genentech, Inc., and the source code has been filed with user documentation in the U.S. Copyright Office, Washington D.C., 20559, where it is registered under U.S. Copyright Registration No. TXU510087. The ALIGN-2 program is publicly available from Genentech, Inc., South San Francisco, Calif., or may be compiled from the source code. All sequence comparison parameters are set by the ALIGN-2 program and do not vary. In situations where ALIGN-2 is employed for amino acid sequence comparisons, the % amino acid sequence identity of a given amino acid sequence A to, with, or against a given amino acid sequence B (which can alternatively be phrased as a given amino acid sequence A that has or comprises a certain % amino acid sequence identity to, with, or against a given amino acid sequence B) is calculated as follows: 100 times the fraction X / Y, where X is the number of amino acid residues scored as identical matches by the sequence alignment program ALIGN-2 in that program's alignment of A and B, and where Y is the total number of amino acid residues in B. It will be appreciated that where the length of amino acid sequence A is not equal to the length of amino acid sequence B, the % amino acid sequence identity of A to B will not equal the % amino acid sequence identity of B to A. Unless specifically stated otherwise, all % amino acid sequence identity values used herein are obtained as described in the immediately preceding paragraph using the ALIGN-2 computer program.

[0229] As used herein, the term a “baseline measurement” refers to a measurement performed on hair (e.g., of a hair property) or scalp of an individual before application of a composition described herein. In some instances, the baseline measurement refers to a measurement of a parameter of hair that is never exposed to the composition or a parameter of hair prior to application of the composition.

[0230] The following examples are illustrative of the embodiments described herein and are not to be interpreted as limiting the scope of this disclosure. To the extent that specific materials are mentioned, it is merely for purposes of illustration and is not intended to be limiting. One skilled in the art may develop equivalent means or reactants without the exercise of inventive capacity and without departing from the scope of this disclosure.

[0231] Exemplary compositions are provided in Tables 3-7. Exemplary compositions are prepared, e.g., by mixing together water and one or more solvents, rheology modifying agents, and / or other solids that need to be melted at elevated temperatures. The ingredients are mixed thoroughly and then cooled down. Additional ingredients are added to the cooled product. Amounts stated below reflect the percent by weight of the ingredient, unless otherwise specified.WSGR Docket No.63230-728.601 Table 3. Exemplary compositionTable 4. Exemplary CompositionWSGR Docket No.63230-728.601Table 5. Exemplary CompositionWSGR Docket No.63230-728.601Table 6. Exemplary CompositionWSGR Docket No.63230-728.601Table 7. Exemplary CompositionWSGR Docket No.63230-728.601Example 2. Effect of composition on malodor and sebum levels

[0232] A composition was prepared according to Example 1. Clinical tests were conducted in human subjects to determine the effects of non-aerosol dry shampoo products (formulated from compositions provided herein) on malodor and sebum levels. Exemplary compositions are shown in Tables 3-7. Subjects refrained from washing their hair and from using any hair or scalp products for four days prior to testing and presented at a test facility on the fourth day for baseline evaluation, after which they received a single application of a non-aerosol dry shampoo product. Sebum level measurements, indicated by use of sebumeter instrumentation (amount of sebum secreted measuredWSGR Docket No.63230-728.601 in g / cm2) , and odor evaluation were made at the following timepoints: baseline (pre-product application), immediately following product application, and at 12-hours, 24 hours, 48 hours, and 72 hours after product application. Odor evaluations were performed by two trained odor graders, with a malodor scale of 0-10 (0 = no malodor, 10 = extremely strong malodor) and a fragrance scale of 0- 5 (0 = none, 5 = very strong), as shown in Table 8. There was a statistically significant reduction in sebum vs. baseline levels at all timepoints and a statistically significant reduction in odor vs. baseline as assessed by expert grader at all tested timepoints, as shown in Table 9. While the magnitude of the effect was strongest initially, both sebum and odor remained lower even after 72 hours than the values measured at baseline (prior to single product application). Table 8. Expert Grading Malodor ScaleTable 9. Reductions in sebum and malodor by composition vs. Baseline measurement at different timepoints after single applicationExample 3: Exemplary Processing instructions for preparing exemplary non-aerosol dry shampoo composition

[0233] Process instructions for preparation of an exemplary composition are provided below:

[0234] Main phase: Add deionized water to vessel. Next, sprinkle rheology modifying agent into water under vortex and mix at RT until hydrated; batch becomes cloudy but should be uniform. Next, heat batch to 60-65C; batch should clear. Next, sprinkle in chelating agent under moderateWSGR Docket No.63230-728.601 mixing and mix until dissolved. Sprinkle absorbing agent into batch with good mixing turnover and mix until powder is fully dispersed and batch is uniform. Cool batch to 35-40C while mixing. Slowly add solvent (e.g., SDA 40B 200 Proof alcohol) under moderate mixing and mix until uniform. Add stabilizing agent (e.g., NaCl gelling salts) and mix until uniform; batch may thicken slightly. Increase mixing as needed to maintain appropriate turnover. Add preservatives, sebum reducing agent, and fragrance one by one, making sure batch is uniform before next addition. Begin cooling batch to 25-30C.

[0235] Side phase: In separate phase, add deionized water. Weigh appropriate quantities of tris and citric acid anhydrous to create buffer. Add one by one to water with moderate mixing and mix until clear and uniform. Measure pH of side phase. Ensure pH is within 6.8-7.2, adjusting up or down as necessary with tris and citric acid as needed, respectively, to prepare buffer solution. Add odor binding protein powder to buffer solution, mixing until uniform and clear. Measure pH to confirm range 6.8-7.2. If needed, adjust pH up or down to be within spec with tris or citric, respectively. QS with deionized water and mix until uniform.

[0236] Combination of main phase and side phase: Add buffered side phase, when clear and uniform with no particulates, to main phase of batch and mix until uniform. Measure batch pH; pH should be between 7.0-7.5. If batch is in spec, QS with water. If batch is above 7.5, combine citric acid and deionized water in a side container to adjust pH down. If pH is below 7.0, combine L- arginine and deionized water in a side container to adjust pH up. Homogenize batch to shear gel. Batch is complete. Example 4: Effect of composition on hair with heat application

[0237] A composition as described herein, e.g., as in Tables 1-7, is applied to hair tresses prior to heat application. A hair property is then evaluated after heat application.

[0238] Briefly, the composition described as herein is applied to virgin hair for certain period of time, e.g., about 1 min to 2 hours. Heat is then applied to the virgin hair. For example, the virgin hair is blow-dried, straightened (e.g., with a flat iron), curled (e.g., with a curling iron or curling wand), or otherwise heated. In some instances, heat is applied more than once, e.g., 1 to 5 times. After heat application, hair elasticity, hair strength, hair color, hair luster, and / or hair porosity are then evaluated using mechanical resistance test (e.g., break stress), polarized spectroscopy or imaging, hair density determination, color fade assay, absorbance spectroscopy or other measurements. A comparison of the hair property of hair of the following samples are made: (1) hair tress without composition as described herein and not treated with heat, (2) hair tress without composition as described herein and treated with heat, and (3) hair tress with composition as described herein and treated with heat. In some instances, the baseline measure of the hair property is also performed prior to application of the composition described herein.WSGR Docket No.63230-728.601

[0239] While embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. It is not intended that the disclosure limited by the specific examples provided within the specification. While embodiments of the present disclosure have been described with reference to the aforementioned figures and detailed description, the embodiments herein are not meant to be construed in a limiting sense. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the disclosure. Furthermore, it shall be understood that all aspects of the disclosure are not limited to the specific depictions, configurations or relative proportions set forth herein which depend upon a variety of conditions and variables. It should be understood that various alternatives to the embodiments of the disclosure described herein may be employed in practicing the disclosure. It is therefore contemplated that this disclosure shall also cover any such alternatives, modifications, variations or equivalents. It is intended that the following claims define the scope of the disclosure and that methods and structures within the scope of these claims and their equivalents be covered thereby.

Claims

WSGR Docket No.63230-728.601 CLAIMS WHAT IS CLAIMED IS:

1. A composition comprising: an odor binding protein comprising a sequence at least about 80% identical to any one of SEQ ID NOS: 1-340; and an absorbing agent.

2. The composition of claim 1, wherein the absorbing agent binds to and / or absorbs oil and sebum.

3. The composition of claim 1 or claim 2, wherein the absorbing agent comprises a compound comprising silicon.

4. The composition of claim 3, wherein the compound comprises silica, a silicate salt, silica silylate, silica dimethyl silylate, silica dimethicone silylate, or a combination of two or more thereof.

5. The composition of any one of the preceding claims, wherein the absorbing agent comprises silica.

6. The composition of any one of the preceding claims, wherein the absorbing agent comprises a carbonate salt, metal oxide, clay mineral powder, or a combination of two or more thereof.

7. The composition of any one of the preceding claims, wherein the absorbing agent is from about 0.01% to about 40% by weight (w / w) of the composition.

8. The composition of any one of the preceding claims, wherein the absorbing agent is from about 1% to about 25% by weight (w / w) of the composition.

9. The composition of any one of the preceding claims, wherein the absorbing agent is from about 2% to about 15% by weight (w / w) of the composition.

10. The composition of any one of the preceding claims, wherein the absorbing agent comprises silica from about 2% to about 15% by weight (w / w) of the composition.

11. The composition of any one of the preceding claims, further comprising a sebum regulating agent.

12. The composition of any one of the preceding claims, wherein, when applied to hair, the composition maintains or increases a hair property as compared to the hair property of hair not applied with the composition, wherein the hair property comprises hair strength, hair color, hair elasticity, hair luster, hair porosity, or a combination thereof.

13. The composition of claim 12, wherein the hair elasticity is determined by measuring a Young’s Modulus of hair.

14. The composition of claim 12, wherein the hair color is determined by a color fade assay.

15. The composition of claim 12, wherein the hair strength is determined by a break stress.

16. The composition of claim 12, wherein the hair luster is determined by polarized spectroscopy, imaging, or both.

17. The composition of claim 12, wherein the hair porosity is determined by measuring a density of hair.

18. The composition of any one of the preceding claims, wherein the composition is applied to the hair prior to heat application.WSGR Docket No.63230-728.601 19. A composition comprising: an odor binding protein comprising a sequence at least about 80% identical to any one of SEQ ID NOS: 1-340; and a sebum regulating agent.

20. The composition of any one of claims 11-19, wherein the sebum regulating agent comprises bioactive compounds for reducing sebum and oil.

21. The composition of claim 19 or claim 20, wherein the sebum regulating agent reduces, regulates, or removes sebum and / or sweat.

22. The composition of any one of claims 11-21, wherein the sebum regulating agent comprises salicylic acid, microalgae extracts, green tea emulsions, avocado extract, Opuntia ficus-indica stem extract, Anetholea anisate leaf extract, Tetraselmis Suecica extract, Alteromonas ferment extract, Pseudoalteromonas ferment extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Saccharum officinarum (sugarcane) extract, Rhodomyrtus tomentosa fruit extract, Hedychium coronarium root extract, Epilobium angustifolium flower / leaf / stem extract, Tremella fuciformis sporocarp extract, or a combination of two or more thereof.

23. The composition of any one of claims 11-22, wherein the sebum regulating agent comprises tetraselmis suecica extract.

24. The composition of any one of claims 11-23, wherein the sebum regulating agent is from about 0.0001% to about 1% by weight (w / w) of the composition.

25. The composition of any one of claims 11-24, wherein the sebum regulating agent is from about 0.0005% to about 0.5% by weight (w / w) of the composition.

26. The composition of any one of claims 11-25, wherein the sebum regulating agent is from about 0.001% to about 0.05% by weight (w / w) of the composition.

27. The composition of any one of claims 11-26, wherein the sebum regulating agent comprises tetraselmis suecica extract from about 0.001% to about 0.05% by weight (w / w) of the composition.

28. The composition of any one of the preceding claims, wherein the composition has a pH from about 6 to about 9.

29. The composition of any one of the preceding claims, wherein the composition has a pH from about 7 to about 7.

5.

30. The composition of any one of the preceding claims, further comprising a buffering agent.

31. The composition of claim 30, wherein the buffering agent maintains the pH of the composition.

32. The composition of claim 30 or claim 31, wherein the buffering agent comprises a weak acid, weak base, amino acid, weak organic acid, weak organic base, or combinations of two or more thereof.WSGR Docket No.63230-728.601 33. The composition of any one of claims 30-32, wherein the buffering agent comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, arginine, tromethamine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof.

34. The composition of any one of claims 30-33, wherein the buffering agent comprises lactic acid, citric acid, tromethamine, and arginine.

35. The composition of any one of claims 30-34, wherein buffering agent is from about 0.001% to about 1% by weight (w / w) of the composition.

36. The composition of any one of claims 30-35, wherein the buffering agent is from about 0.005% to about 0.5 by weight (w / w) of the composition.

37. The composition of any one of claims 30-36, wherein the buffering agent is from about 0.01% to about 0.1% by weight (w / w) of the composition.

38. The composition of any one of claims 30-37, wherein the buffering agent comprises lactic acid from about 0.0005% to about 0.01% by weight (w / w), citric acid from about 0.01% to about 0.1% (w / w), tromethamine from about 0.001% to about 0.05% (w / w), and arginine from about 0.000075% to about 0.005% (w / w) of the composition.

39. The composition of any one of the preceding claims, wherein the sequence is at least about 90% identical to any one of SEQ ID NOS: 1-340.

40. The composition of any one of the preceding claims, wherein the odor binding protein binds to an odorant molecule.

41. The composition of any one of the preceding claims, wherein the odor binding protein is from about 0.001% to about 1% by weight (w / w) of the composition.

42. The composition of any one of the preceding claims, wherein the odor binding protein is from about 0.0025% to about 0.5% by weight (w / w) of the composition.

43. The composition of any one of the preceding claims, wherein the odor binding protein is from about 0.005% to about 0.1% by weight (w / w) of the composition.

44. The composition of any one of the preceding claims, further comprising a solvent.

45. The composition of claim 44, wherein the solvent comprises a polar solvent, nonpolar solvent, water, alcohol, polyol, glycol, sugar, polyethylene glycol, or a combination of two or more thereof.

46. The composition of claim 44 or claim 45, wherein the solvent comprises water, mannitol, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, denatured ethanol, denatured methanol, denatured propanol, denatured isopropyl alcohol, denatured butanol, denatured pentanol, denatured hexanol, methanol, ethanol, propanol, isopropyl alcohol, butanol, pentanol, hexanol, glycerin, butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols, sorbitol, glucose, fructose, maltose, lactose, sucrose, PEG-4, PEG-6, PEG-8, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, or a combination of two or more thereof.WSGR Docket No.63230-728.601 47. The composition of any one of claims 44-46, wherein the solvent comprises water, mannitol, glycerin, and denatured ethanol.

48. The composition of any one of claims 44-47, wherein the solvent comprises water and denatured ethanol.

49. The composition of any one of claims 44-48, wherein the solvent is from about 35% to about 99% by weight (w / w) of the composition.

50. The composition of any one of claims 44-49, wherein the solvent is from about 60% to about 97% by weight (w / w) of the composition.

51. The composition of any one of claims 44-50, wherein solvent is from about 80% to about 95% by weight (w / w) of the composition.

52. The composition of any one of claims 44-51, wherein the solvent comprises water from about 45% to about 85% by weight (w / w), mannitol from about 0.02% to about 0.1% (w / w), glycerin from about 0.1% to about 1% (w / w), and denatured ethanol from about 10% to about 30% (w / w) of the composition.

53. The composition of any one of claims 44-52, wherein the solvent comprises water from about 45% to about 85% by weight (w / w) and denatured ethanol from about 10% to about 30% (w / w) of the composition.

54. The composition of any one of the preceding claims, further comprising a humectant.

55. The composition of claim 54, wherein the humectant comprises a hyaluronate, glycol, sorbitol, sugar, carbocyclic sugar, alcohol, or a combination of two or more thereof.

56. The composition of claim 54 or claim 55, wherein the humectant comprises 1,2,6 hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyldiol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, hydrolyzed hyaluronic acid, sodium hyaluronate, inositol, erythritol, capryl glycol, acetamidoethoxyethanol, or a combination of two or more thereof.

57. The composition of any one of claims 54-56, wherein the humectant comprises glycerin, mannitol, sodium hyaluronate, and hydrolyzed hyaluronic acid.

58. The composition of any one of claims 54-57, wherein the humectant is from about 0.01% to about 5% by weight (w / w) of the composition.

59. The composition of any one of claims 54-58, the humectant is from about from about 0.1% to about 2% by weight (w / w) of the composition.

60. The composition of any one of claims 54-59, wherein the humectant is from about 0.25% to about 1% by weight (w / w) of the composition.WSGR Docket No.63230-728.601 61. The composition of any one of claims 54-60, wherein the humectant comprises mannitol from about 0.02% to about 0.1% by weight (w / w), glycerin from about 0.1% to about 1% (w / w), sodium hyaluronate from about 0.001% to about 0.01% (w / w), and hydrolyzed hyaluronic acid from about 0.001% to about 0.1% (w / w) of the composition.

62. The composition of any one of the preceding claims, further comprising a rheology modifying agent.

63. The composition of claim 62, wherein the rheology modifying agent comprises a hydrocolloid, naturally derived polymer, aqueous natural polymer, sugars, or a combinations of two or more thereof.

64. The composition of claim 62 or claim 63, wherein the rheology modifying agent comprises pectin, gellan gum, carrageen, glycerin, agar, xanthan gum, pullulan, algin, tetragonoloba (guar) gum, sclerotium gum, acacia Senegal gum, cellulose, cellulose gum, carboxymethylcellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, lauryl polyglucose, or a combination of two or more thereof.

65. The composition of any one of claims 62-64, wherein the rheology modifying agent comprises gellan gum.

66. The composition of any one of claims 62-65, wherein the rheology modifying agent is from about 0.005% to about 10% by weight (w / w) of the composition.

67. The composition of any one of claims 62-66, wherein the rheology modifying agent is from about 0.01% to about 2% by weight (w / w) of the composition.

68. The composition of any one of claims 62-67, wherein the rheology modifying agent is from about 0.05% to about 0.5% by weight (w / w) of the composition.

69. The composition of any one of claims 62-68, wherein the rheology modifying agent comprises gellan gum from about 0.05% to about 0.5% by (w / w) of the composition.

70. The composition of any one of the preceding claims, further comprising a stabilizing agent.

71. The composition of claim 70, wherein the stabilizing agent comprises a salt, sulfate, or a combination of two or more thereof.

72. The composition of claim 70 or claim 71, wherein the stabilizing agent comprises calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, or a combination of two or more thereof.

73. The composition of any one of claims 70-72, wherein the stabilizing agent comprises sodium chloride.

74. The composition of any one of claims 70-73, wherein the stabilizing agent is from about 0.005% to about 10% by weight (w / w) of the composition.WSGR Docket No.63230-728.601 75. The composition of any one of claims 70-74, wherein the stabilizing agent is from about 0.01% to about 2% by weight (w / w) of the composition.

76. The composition of any one of claims 70-75, wherein the stabilizing agent is from about 0.05% to about 0.5% by weight (w / w) of the composition.

77. The composition of any one of claims 70-76, wherein the stabilizing agent comprises sodium chloride from about 0.05% to about 0.5% by weight (w / w) of the composition.

78. The composition of any one of the preceding claims, further comprising a chelating agent.

79. The composition of claim 78, wherein the chelating agent comprises EDTA, sodium phytate, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, caprylhydroxamic acid, or a combination of two or more thereof.

80. The composition of claim 78 or claim 79, wherein the chelating agent comprises sodium phytate.

81. The composition of any one of claims 78-80, wherein the chelating agent is from about 0.005% to about 10% by weight (w / w) of the composition.

82. The composition of any one of claims 78-81, wherein the chelating agent is from about 0.01% to about 2% by weight (w / w) of the composition.

83. The composition of any one of claims 78-82, wherein the chelating agent is from about 0.05% to about 0.5% by weight (w / w) of the composition.

84. The composition of any one of the claims 78-83, wherein the chelating comprises sodium phytate from about 0.05% to about 0.5% by weight (w / w) of the composition.

85. The composition of any one of the preceding claims, further comprising a preservative.

86. The composition of claim 85, wherein the preservative comprises an alcohol, paraben, formaldehyde release, carbamate, sorbate, or a combination of two or more thereof.

87. The composition of claim 85 or claim 86, wherein the preservative comprises benzyl alcohol, benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or a combination of two or more thereof.

88. The composition of any one of claims 85-87, wherein the preservative comprises benzyl alcohol.

89. The composition of any one of claims 85-88, wherein the preservative is from about 0.005% to about 10% by weight (w / w) of the composition.

90. The composition of any one of claims 85-89, wherein the preservative is from about 0.01% to about 5% by weight (w / w) of the composition.

91. The composition of any one of claims 85-90, wherein the preservative is from about 0.5% to about 2% by weight (w / w) of the composition.WSGR Docket No.63230-728.601 92. The composition of any one of claims 85-91, wherein the preservative comprises benzyl alcohol from about 0.5% to about 2% by weight (w / w) of the composition.

93. The composition of any one of the preceding claims, wherein the composition is a suspension.

94. The composition of claim 93, wherein the suspension comprises a non-aerosol hydroalcoholic formulation.

95. The composition of any one of the preceding claims, wherein the composition is a hair or scalp composition.

96. The composition of any one of the preceding claims, wherein, when applied to the hair, the composition maintains or increases the hair property as compared to the hair property of hair not applied with the composition.

97. The composition of any one of the preceding claims, wherein the composition is applied to the hair prior to heat application.

98. A method for reducing malodor of a hair and / or scalp of an individual, the method comprising administering an effective amount of the composition of any one of the preceding claims to the hair and / or scalp of the individual.

99. A method for reducing sebum in a hair and / or scalp of an individual, the method comprising administering an effective amount of the composition of any one of claims 1-86 to the hair and / or scalp of the individual.

100. A method for reducing sebum on a hair and / or scalp of an individual, the method comprising administering an effective amount of a composition comprising an odor binding protein to the hair and scalp of the individual, wherein the odor binding protein comprises a sequence at least about 80% identical to any one of SEQ ID NOS: 1-340.

101. The method of claim 100, wherein the composition further comprises an absorbing agent.

102. The method of claim 100 or claim 101, wherein the composition further comprises a sebum reducing agent.

103. The method of any one of claims 100-102, wherein skin surface levels of sebum are reduced compared to a baseline measurement for about 24 to about 72 hours or more after administration of the composition.

104. The method of any one of claims 100-103, wherein sebum reduction is measured by a Sebumeter.

105. The method of any one of claims 100-104, wherein when measured immediately after administration compared to a baseline measurement, sebum is reduced about 1 to about 20 g / cm2.

106. The method of any one of claims 100-105, wherein when measured immediately after administration compared to a baseline measurement, sebum is reduced about 5 to about 15 g / cm2.

107. The method of any one of claims 100-106, wherein when measured immediately after administration compared to a baseline measurement, sebum is reduced by about 10 g / cm2.WSGR Docket No.63230-728.601 108. The method of any one of claims 100-107, wherein when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 19 g / cm2.

109. The method of any one of claims 100-108, wherein when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced about 4 to about 14 g / cm2.

110. The method of any one of claims 100-109, wherein when measured about 12 hours after administration compared to a baseline measurement, sebum is reduced by about 9 g / cm2.

111. The method of any one of claims 100-110, wherein when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 17 g / cm2.

112. The method of any one of claims 100-111, wherein when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced about 3 to about 12 g / cm2.

113. The method of any one of claims 100-112, wherein when measured about 24 hours after administration compared to a baseline measurement, sebum is reduced by about 7 g / cm2.

114. The method of any one of claims 100-113, wherein when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 15 g / cm2.

115. The method of any one of claims 100-114, wherein when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced about 2 to about 10 g / cm2.

116. The method of any one of claims 100-115, wherein when measured about 48 hours after administration compared to a baseline measurement, sebum is reduced by about 5.5 g / cm2.

117. The method of any one of claims 100-116, wherein when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced about 1 to about 8 g / cm2.

118. The method of any one of claims 100-117, wherein when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced about 2 to about 6 g / cm2.

119. The method of any one of claims 100-118, wherein when measured about 72 hours after administration compared to a baseline measurement, sebum is reduced by about 4 g / cm2.

120. A method for reducing malodor on a hair and / or scalp of an individual, the method comprising administering an effective amount of a composition comprising an odor binding protein to the hair and scalp of the individual, wherein the odor binding protein comprises a sequence at least about 80% identical to any one of SEQ ID NOS: 1-340.

121. The method of claim 120, wherein the composition further comprises an absorbing agent.

122. The method of claim 120 or claim 121, wherein the composition further comprises a sebum reducing agent.

123. The method of any one of claims 120-122, wherein malodor levels are reduced compared to a baseline measurement for about 24 to about 72 hours or more after administration of the composition.

124. The method of any one of claims 120-123, wherein malodor levels are evaluated by a trained odor grader on a scale of 0 to 10.WSGR Docket No.63230-728.601 125. The method of claim 124, wherein when measured immediately after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 7 on the scale.

126. The method of claim 124 or claim 125, wherein when measured immediately after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 6 on the scale.

127. The method of any one of claims 124-126, wherein when measured immediately after administration compared to a baseline measurement, malodor levels are reduced by about 5 on the scale.

128. The method of any one of claims 124-127, wherein when measured about 12 hours after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 7 on the scale.

129. The method of any one of claims 124-128, wherein when measured about 12 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 6 on the scale.

130. The method of any one of claims 124-129, wherein when measured about 12 hours after administration compared to a baseline measurement, malodor levels are reduced by about 5 on the scale.

131. The method of any one of claims 124-130, wherein when measured about 24 hours after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 6 on the scale.

132. The method of any one of claims 124-131, wherein when measured about 24 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 5 on the scale.

133. The method of any one of claims 124-132, wherein when measured about 24 hours after administration compared to a baseline measurement, malodor levels are reduced by about 4 on the scale.

134. The method of any one of claims 124-133, wherein when measured about 48 hours after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 5 on the scale.

135. The method of any one of claims 124-134, wherein when measured about 48 hours after administration compared to a baseline measurement, malodor levels are reduced about 3 to about 4 on the scale.

136. The method of any one of claims 124-135, wherein when measured about 48 hours after administration compared to a baseline measurement, malodor levels are reduced by about 3.5 on the scale.WSGR Docket No.63230-728.601 137. The method of any one of claims 124-136, wherein when measured about 72 hours after administration compared to a baseline measurement, malodor levels are reduced about 1 to about 4 on the scale.

138. The method of any one of claims 124-137, wherein when measured about 72 hours after administration compared to a baseline measurement, malodor levels are reduced about 2 to about 3 on the scale.

139. The method of any one of claims 124-138, wherein when measured about 72 hours after administration compared to a baseline measurement, malodor levels are reduced by about 2.5 on the scale.

140. The method of any one of the preceding claims, wherein, when applied to the hair, the composition maintains or increases a hair property as compared to the hair property of hair not applied with the composition.

141. The method of any one of the preceding claims, wherein the composition is applied to the hair prior to heat application.

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