Optimized geometric design of a cell processing cassette

An optimized geometric design for cell processing cassettes addresses inefficiencies by incorporating angled surfaces and microstructures, improving efficiency and scalability for diverse cell types.

WO2025145118A1PCT designated stage expired Publication Date: 2025-07-03TRENCHANT BIOSYSTEMS INC
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Patent Information

Application Number
PCT/US2024/062189
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-12-31
Filing Date
2024-12-28
Publication Date
2025-07-03

AI Technical Summary

Technical Problem

Existing cell processing cassettes lack optimized geometric designs that enhance processing efficiency and compatibility with various cell types, leading to suboptimal performance and limited scalability.

Method used

The development of an optimized geometric design for cell processing cassettes that incorporates specific features such as angled surfaces and microstructures to improve fluid dynamics and compatibility with different cell types, enhancing processing efficiency and scalability.

Benefits of technology

The optimized design improves processing efficiency and compatibility with diverse cell types, resulting in enhanced performance and scalability of cell processing operations.

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Abstract

The disclosed invention presents the AutoCell Platform (ACP), an advanced, fully automated, and functionally closed system designed to revolutionize the manufacturing of gene-modified cell therapies. This innovative platform integrates automation, closed-loop processing, and novel technologies to address the inefficiencies and high costs of conventional methods. Key features include automated spinoculation for enhanced genetic modification efficiency, microbubble-assisted cell selection for precise cell isolation, and modular design for scalability across clinical and research settings. By reducing production timelines from 30-40 days to under 3 days and lowering costs by an order of magnitude, the ACP enables point-of-care manufacturing, decentralization, and broader accessibility. Advanced quality control measures and a standardized design ensure regulatory compliance and consistent therapeutic outcomes. The ACP supports diverse applications, from CAR-T therapies to regenerative medicine, representing a transformative leap in precision medicine and the global accessibility of life-saving cell-based therapies.
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Description

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