Use of liquiritin in preparation of drug for treating atopic dermatitis

By using topical preparations prepared by glycyrrhizin, the problems of large side effects and poor efficacy in the treatment of atopic dermatitis were solved, and safe, effective and economical dermatitis improvement effects were achieved.

WO2025156601A1 Publication Date: 2025-07-31SHANGHAI DERMATOLOGY HOSPITAL
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Patent Information

Application Number
PCT/CN2024/111915
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-01-24
Filing Date
2024-08-14
Publication Date
2025-07-31

AI Technical Summary

Technical Problem

The existing drugs for the treatment of atopic dermatitis have problems such as large side effects, poor efficacy and high recurrence rates. In particular, the long-term use of glucocorticoids and immunosuppressants has brought many adverse reactions, and the efficacy of traditional Chinese medicine external drugs also needs to be improved.

Method used

Glycyrrhizin is used as an active ingredient to prepare topical preparations such as patches, pastes, ointments, etc., which are used to treat atopic dermatitis, and improve the severity of skin lesions by inhibiting epidermal proliferation and dermal lymphocyte infiltration.

Benefits of technology

Glycyrrhizin significantly reduces the thickness of the auricle and epidermal skin, reduces dermal lymphocyte infiltration, improves skin lesions, and has no side effects of liver, spleen and kidney toxicity, which is safe, economical and convenient to operate.

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Abstract

A use of liquiritin in the preparation of a drug for treating atopic dermatitis. Animal experiments show that liquiritin can remarkably lessen the skin lesion severity of an atopic dermatitis mouse model, reduce the ear thickness and the epidermal thickness, and reduce the infiltration degree of dermal lymphocytes, thereby demonstrating that liquiritin has a significant therapeutic effect on atopic dermatitis, has no toxic and side effects on the liver, the spleen and the kidney, and has good clinical application prospects and enormous social benefits, and expanding a new application field for a conventional leguminous plant liquorice extract, i.e., liquiritin.
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