Compound capable of killing bacteria and viruses and manufacturing method therefor

The complex prepared by mixing food-grade nano-calcium powder and vaseline uses electrostatic action and Coulomb attraction to adsorb cell membranes, combined with macrophage phagocytosis, to achieve efficient sterilization and virus killing, enhance immune function, solve the side effects and drug resistance problems of traditional disinfection methods, and provide an efficient, safe and environmentally friendly disinfection solution.

WO2025199841A1PCT designated stage Publication Date: 2025-10-02WU REUI-HONG
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Patent Information

Application Number
PCT/CN2024/084256
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-03-28
Publication Date
2025-10-02

AI Technical Summary

Technical Problem

Existing disinfection methods have side effects and are prone to drug resistance. The development of vaccines and antibiotics takes too long, and there is a lack of efficient, safe and environmentally friendly disinfection methods.

Method used

A mixture of food-grade nano-calcium powder and vaseline is used to adsorb on the cell membrane through electrostatic action and Coulomb attraction to denature cell proteins. Combined with the phagocytic action of macrophages, a complex that can kill bacteria and viruses is prepared.

Benefits of technology

It effectively kills viruses and bacteria, enhances immune function, does not produce drug resistance, is easy to use, and is environmentally friendly and harmless.

✦ Generated by Eureka AI based on patent content.

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Abstract

Provided are a compound capable of killing bacteria and viruses and a manufacturing method therefor. The compound comprises an effective amount of a mixture formed by an oleophylic phase ingredient and at least a food-grade nano-calcium-containing ingredient. By heating the mixture at 100 °C and then letting to stand at room temperature for cooling, the compound is obtained. When the compound is applied at pathogen-hiding sites on the skin, calcium ions in the food-grade nano-calcium-containing ingredient will trigger physiological reactions such as phagocytosis of macrophages, intercellular signal transmission, hormone secretion, and the like, to antagonize foreign pathogens; in addition, calcium ions will also be adsorbed on cell membranes of bacteria or viruses to denature cell proteins, which disables cell breath, metabolism, and proliferation and ultimately causes cell death, thus completing cell killing and achieving the effects of killing bacteria and viruses.
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Description

Bactericidal and viral-killing compound and method for producing the same Technical Field

[0001] The present invention relates to a bactericidal and viral complex and a method for producing the same, in particular to a bactericidal and viral complex that attaches to the cell membrane of bacteria or viruses through calcium ions and triggers macrophage phagocytosis and a method for producing the same. Background Art

[0002] With the acceleration of globalization, the spread of infectious diseases is expanding and accelerating. Infectious diseases primarily rely on bacteria and viruses, which are typically transmitted through contact or air. Viruses and bacteria are the main causes of various diseases and pose a serious threat to human health. While traditional disinfection methods such as ultraviolet light, high temperatures, and chemical agents are somewhat effective, they also have side effects and are prone to developing drug resistance. Furthermore, the development of vaccines and antibiotics is time-consuming. Technical issues

[0003] Therefore, finding an efficient, safe and environmentally friendly disinfection method has always been an urgent need in the medical and biological fields. Technical Solutions

[0004] To solve the above problems, the present invention provides a compound that can be directly applied to the surface of discomfort or adjacent infection to kill bacteria and viruses, and a method for producing the same.

[0005] To achieve the above objectives, one embodiment of the present invention provides a bactericidal and antiviral composite comprising a mixture of an effective amount of a lipophilic phase component and at least one food-grade nano-calcium-containing component.

[0006] The ratio of the lipophilic phase component to the food-grade nano calcium-containing component is 1:X, and X is 0.65 to 0.8.

[0007] Wherein, the lipophilic phase component is vaseline.

[0008] Wherein, the food-grade nano calcium-containing component is food-grade nano calcium powder.

[0009] The food-grade nano calcium-containing ingredient is food-grade nano calcium powder and food-grade pearl powder.

[0010] The ratio of the lipophilic phase component, the food-grade nano-calcium powder and the food-grade pearl powder is 1:(X / 2):(X / 2), and X is 0.65 to 0.8.

[0011] Wherein, the food-grade pearl powder contains at least 90% of food-grade nano calcium carbonate.

[0012] The composite is installed in a containing space of a container. The container has an opening communicating with the containing space. A cover is provided on the opening.

[0013] In one embodiment, the present invention provides a method for preparing a bactericidal and antiviral complex, comprising the following steps: S1: heating vaseline at a temperature of 90°C to 100°C until completely dissolved; S2: pouring food-grade nano-calcium powder into the completely dissolved vaseline and stirring evenly to form a mixture, wherein the vaseline and food-grade nano-calcium powder are mixed in a ratio of 1:X, wherein X is 0.65 to 0.8; S3: cooling the mixture at room temperature for 30 minutes to obtain a complex.

[0014] In one embodiment, the present invention also provides a method for preparing a bactericidal and antiviral complex, comprising the following steps: S1: heating the vaseline at a temperature of 90°C to 100°C until it is completely dissolved; S2: pouring the food-grade nano-calcium powder and the food-grade pearl powder into the completely dissolved vaseline and stirring evenly to form the mixture, wherein the vaseline, the food-grade nano-calcium powder and the food-grade pearl powder are mixed in a ratio of 1:(X / 2):(X / 2), characterized in that X is 0.65 to 0.8; S3: after the mixture is allowed to cool at room temperature for 30 minutes, the complex can be obtained. Beneficial effects

[0015] The beneficial effects of the present invention are:

[0016] Through the above structure, the complex of the present invention is applied to the surface location corresponding to discomfort or adjacent infection, and calcium ions are adsorbed on the cell membrane to denature cell proteins and activate macrophages to enhance the body's immunity, thereby achieving the purpose of sterilization and virus elimination. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] FIG1 is a schematic block diagram of the structure of the bactericidal and viral complex of the present invention.

[0018] FIG2 is a schematic diagram showing the bactericidal and antiviral complex of the present invention installed in a container.

[0019] FIG3 is a flow chart of the method for producing a complex capable of killing bacteria and viruses according to the first embodiment of the present invention.

[0020] FIG4 is a flow chart showing the process of manufacturing a complex capable of killing bacteria and viruses according to the second embodiment of the present invention.

[0021] Description of Reference Numerals

[0022] 10: mixture; 11: lipophilic phase component; 12: food-grade nano-calcium-containing component; 20: container; 21: accommodating space; 22: opening; 23: cover; S1, S2, S3: steps. Best Mode for Carrying Out the Invention

[0023] In order to make the above and other objects, features and advantages of the present invention more clearly understood, preferred embodiments of the present invention are described in detail below with reference to the accompanying drawings:

[0024] 1 , the present invention discloses a bactericidal and antiviral composite, comprising a mixture 10 formed of an effective amount of a lipophilic phase component 11 and a food-grade nano-calcium-containing component 12. The ratio of the lipophilic phase component 11 to the food-grade nano-calcium-containing component 12 is 1:X, where X is 0.65 to 0.8, wherein X can be 0.65, 0.66, 0.67, 0.68, 0.69, 0.7, 0.71, 0.72, 0.73, 0.74, 0.75, 0.76, 0.77, 0.78, 0.79, or 0.8.

[0025] The lipophilic phase component 11 is vaseline.

[0026] Wherein, the food-grade nano calcium-containing ingredient 12 is food-grade nano calcium powder.

[0027] The food-grade nano calcium-containing ingredient 12 comprises food-grade nano calcium powder and food-grade pearl powder, wherein the food-grade pearl powder contains at least 90% of food-grade nano calcium carbonate, and the ratio of the lipophilic phase ingredient 11, the food-grade nano calcium powder and the food-grade pearl powder is 1:(X / 2):(X / 2), and X is 0.65 to 0.8, wherein X can be 0.65, 0.66, 0.67, 0.68, 0.69, 0.7, 0.71, 0.72, 0.73, 0.74, 0.75, 0.76, 0.77, 0.78, 0.79, or 0.8.

[0028] 2 , the disclosed composite is installed in a receiving space 21 of a container 20 . The container 20 has an opening 22 communicating with the receiving space 21 . The opening 22 is provided with a cover 23 .

[0029] 3 and 1 , the method of the present invention for producing a bactericidal and viral complex is disclosed, comprising the following steps:

[0030] S1: Heat vaseline at 90°C to 100°C until it is completely dissolved.

[0031] S2: Pour food-grade nano-calcium powder into the completely dissolved vaseline and stir evenly to form a mixture 10. The vaseline and the food-grade nano-calcium powder are mixed in a ratio of 1:X, wherein X is 0.65 to 0.8.

[0032] S3: The mixture 10 is allowed to stand and cool at room temperature for 30 minutes to obtain a composite.

[0033] 4 and 1 , the method of the present invention for producing a bactericidal and viral complex is disclosed, comprising the following steps:

[0034] S1: heating the vaseline at 90° C. to 100° C. until it is completely dissolved.

[0035] S2: Pour food-grade nano-calcium powder and food-grade pearl powder into the completely dissolved vaseline and stir evenly to form a mixture 10. The vaseline, food-grade nano-calcium powder and food-grade pearl powder are mixed in a ratio of 1:(X / 2):(X / 2), wherein X is 0.65 to 0.8.

[0036] S3: The mixture 10 is allowed to stand and cool at room temperature for 30 minutes to obtain a composite.

[0037] principle:

[0038] Many viruses have negatively charged glyciprites, such as SARS coronavirus, MERS coronavirus, Epstein-Barr virus (EBV), herpes simplex virus (HSV), varicella zoster virus (VZV), and the novel coronavirus. Nanomaterials, on the other hand, have positively charged structures. Therefore, when the negatively charged structure of the virus encounters the food-grade nano-calcium-containing component 12 of the present invention, due to the principle of positive and negative charge attraction and neutralization, the food-grade nano-calcium-containing component 12 can disintegrate the virus structure or aggregate it, thereby preventing the virus from spreading and invading human cells.

[0039] The positively charged virus-killing method relies on electrostatic interaction and Coulomb attraction. When the positively charged nanomaterial comes into contact with negatively charged pathogenic microbial cells (including bacteria, viruses, and fungi), the calcium ions in the nano-calcium component 12 adhere to the cell membrane due to Coulomb attraction (positive and negative charges attract each other), denaturing the cell's proteins and preventing it from respiration, metabolism, and reproduction until the cell dies, effectively killing it.

[0040] Macrophages are found in various tissues and organs of the human body, including the skin, lungs, liver, kidneys, spleen, and lymphatic tissue. They are part of the immune system and are responsible for engulfing and breaking down bacteria, viruses, and other foreign matter. Macrophages and calcium ions are closely linked in inflammation and immune processes. During inflammation, calcium ions can participate in multiple macrophage functions:

[0041] 1. Phagocytosis: Calcium ions participate in the process of macrophages engulfing foreign substances (phagicytisis). This is an important defense mechanism in the immune system, in which macrophages ingest and break down cell debris, pathogens, or other foreign matter.

[0042] 2. Cell signaling: Calcium ions play a key role in macrophage signaling. They can regulate macrophage activity and affect the extent of inflammatory responses.

[0043] 3. Immune regulation: Calcium ions also participate in regulating the immune function of macrophages. They can affect the release of cytokines and the extent of immune response, thereby regulating the body's response to infection and injury.

[0044] Macrophages can be activated in various ways, generally including:

[0045] 1. Bacterial infection: When macrophages sense bacterial infection in the body, they become activated to engulf and digest these pathogens.

[0046] 2. Viral infection: Macrophages can be activated by signaling molecules released by virus-infected cells, which prompts them to participate in the immune response.

[0047] 3. Damage or inflammation: When cells are damaged or tissues are inflamed, the chemical signals released can also activate macrophages to help clean up the damaged area.

[0048] 4. Immune system signaling: Other immune cells, such as T cells, can release signaling molecules to activate macrophages and encourage them to participate in immune responses.

[0049] The present invention applies a food-grade nano-calcium component 12 of sufficient concentration to the skin where pathogens are hiding, thereby increasing the calcium ion concentration to trigger physiological reactions such as macrophage phagocytosis, intercellular signal transmission, and hormone secretion. These reactions prompt macrophages to perform phagocytic and inflammatory reactions, which help increase the immune function of macrophages to fight against foreign pathogens.

[0050] Directions:

[0051] Nasal allergies:

[0052] When the nose is allergic, the complex of the present invention can be directly applied to the outside of the nose. After the first application, the bacteria in the nostrils will be killed immediately, causing runny nose and sneezing. Apply it again after blowing the nose. The nasal allergy symptoms will be relieved after about 15 minutes.

[0053] Cold and Flu:

[0054] For a common cold, apply to the outside of the nose, neck, and other areas of infection. Symptoms will ease after about 20 minutes. If symptoms persist after half an hour, apply to the outside of the nose and neck, along the respiratory tract, every four hours. For a cough, apply to the bronchi and lungs. For diarrhea and abdominal pain, apply to the large and small intestines. Apply every four hours. Recovery will occur in about one to two days. For pneumonia, apply to the outside of the nose, neck, respiratory tract, bronchi, and upper lungs every four hours for about one to two days. For lobar pneumonia, apply to the tail lung as well, applying every four hours. Recovery will occur in about one to two days.

[0055] Stubborn ringworm:

[0056] The complex of the present invention is applied to the stubborn tinea site, and only one application is required to prevent the stubborn tinea from recurring.

[0057] Through the above structure and method, the advantages of the present invention are as follows:

[0058] 1. Effectively kill bacteria: Since viruses and bacteria are negatively charged, the present invention uses positively charged nano-calcium materials and combines them with their high surface area, high activity, high biocompatibility and other characteristics to effectively kill viruses and bacteria, and has the advantages of high efficiency, safety and environmental protection.

[0059] 2. Boosting immunity: Calcium ions activate macrophages, which release inflammatory mediators such as cytokines and chemicals to attract other immune cells, clear infected or damaged cells, and promote tissue repair. Macrophages can also phagocytize and decompose bacteria, viruses, and cell debris, helping to eliminate sources of infection and participating in the immune system's adaptive response.

[0060] 3. Easy to use: It is only necessary to apply the complex of the present invention to the surface where discomfort or infection occurs.

[0061] 4. No impact on normal cells: The complex of the present invention is highly compatible with the human body and therefore does not affect normal cells but only poses a threat to viruses and bacteria.

[0062] 5. No drug resistance: Since the composite of the present invention utilizes electrostatic interaction and Coulomb attraction, there is no problem of drug resistance. Even viruses or bacteria with multiple drug resistance can still be killed using the composite of the present invention.

[0063] 6. Harmless to the body: The present invention uses food-grade nano calcium-containing ingredients 12. Food grade means that it does not contain heavy metals and ingredients harmful to the human body. Therefore, it will not cause harm to the human body when applied to the human body surface.

[0064] The above embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. Any modification or variation that does not violate the claims of the present invention shall fall within the scope of protection of the present invention.

Claims

1. A bactericidal and viral compound, characterized in that: The invention comprises a mixture formed by an effective amount of a lipophilic phase component and at least one food-grade nano calcium-containing component.

2. The bactericidal and viral complex according to claim 1, wherein The ratio of the lipophilic phase component to the food-grade nano calcium-containing component is 1:X, and X is 0.65 to 0.

8.

3. The bactericidal and viral complex according to claim 1, wherein The lipophilic phase component is vaseline.

4. The bactericidal and viral complex according to claim 3, wherein: The food-grade nano calcium-containing ingredient is food-grade nano calcium powder.

5. The bactericidal and viral complex according to claim 3, wherein: The food-grade nano calcium-containing component comprises food-grade nano calcium powder and food-grade pearl powder.

6. The bactericidal and viral complex according to claim 5, wherein The ratio of the lipophilic phase component, the food-grade nano-calcium powder and the food-grade pearl powder is 1:(X / 2):(X / 2), and X is 0.65 to 0.

8.

7. The bactericidal and viral complex according to claim 5, wherein This food-grade pearl powder contains at least 90% food-grade nano-calcium carbonate.

8. The bactericidal and viral complex according to any one of claims 1 to 7, characterized in that The compound is installed in a containing space of a container. The container has an opening communicating with the containing space. A cover is provided on the opening.

9. A method for producing the bactericidal and viral complex according to claim 4, characterized in that: The following steps are involved: S1: heating the vaseline at 90° C. to 100° C. until it is completely dissolved; S2: Pour the food-grade nano-calcium powder into the completely dissolved vaseline and stir evenly to form the mixture, wherein the vaseline and the food-grade nano-calcium powder are mixed in a ratio of 1:X, where X is 0.65 to 0.8; S3: The mixture is allowed to stand and cool at room temperature for 30 minutes to obtain the composite.

10. A method for producing the bactericidal and viral complex according to claim 5, characterized in that: The following steps are involved: S1: heating the vaseline at 90° C. to 100° C. until it is completely dissolved; S2: Pour the food-grade nano-calcium powder and the food-grade pearl powder into the completely dissolved vaseline and stir evenly to form a mixture, wherein the vaseline, the food-grade nano-calcium powder and the food-grade pearl powder are mixed in a ratio of 1:(X / 2):(X / 2), where X is 0.65 to 0.8; S3: The mixture is allowed to stand and cool at room temperature for 30 minutes to obtain the composite.

Citation Information

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