Whitening and Anti-aging composition, and method for preparing same, and use thereof

Abstract

The present invention relates to the field of cosmetic technology, and particularly, to a whitening and anti-aging composition, a method for preparing same, and use thereof. The whitening and anti-aging composition is prepared from the following ingredients in parts by weight: 0.1-2 parts of hydroxypropyl cyclodextrin; 0.1-2 parts of tocopherol; 1-5 parts of an emulsifier; 0.5-1 part of a preservative; 1-5 parts of a functional solvent; 0.1-0.9 part of retinol; 0.1-3 parts of an adjusting mixed acid agent; and 90-100 parts of deionized water. The adjusting mixed acid agent consists of lactobionic acid, inositol hexaphosphate, and ferulic acid, and the ratio of lactobionic acid to inositol hexaphosphate to ferulic acid is (5-7):(0.5-1):1. The method for preparing the whitening and anti-aging composition comprises: dissolving the adjusting mixed acid agent in a portion of deionized water; adding hydroxypropyl cyclodextrin, the emulsifier, and retinol into the remaining deionized water and heating for dissolution; and finally, mixing and stirring the two resulting solutions along with the addition of tocopherol and the preservative during the process to give the composition. The composition exhibits excellent whitening and anti-aging effects with low irritation, and is also suitable for populations having sensitive skin with damaged skin barriers.

Description

A whitening and anti-aging composition and its preparation method and application Technical Field

[0001] The present application relates to the field of cosmetic technology, and more specifically, to a whitening and anti-aging composition and a preparation method and application thereof. Background Art

[0002] Whitening and anti-aging can reduce wrinkles, brighten skin tone, and make skin look younger. It is an effective way to improve skin tone and delay skin aging. Among the cosmetic products commonly used by people, high purity, high activity, and high penetration are the standard features for excellent whitening and anti-aging effects.

[0003] For people with sensitive skin with damaged skin barriers, their skin has a thin stratum corneum and lacks lipids between the sebum membrane and stratum corneum cells. Therefore, they have poor tolerance to most of the active ingredients in cosmetics. Therefore, when using the above-mentioned skin care products with strong effects, they often cause irritation to the skin, prone to redness, fever, stinging, itching, swelling, etc. At present, in order to obtain a whitening and anti-aging product suitable for people with sensitive skin with damaged skin barriers, some soothing ingredients are often used to achieve corresponding whitening and anti-aging effects on the basis of maintaining stability. For example, natural plant extracts are less irritating to damaged skin, but the content of active ingredients extracted from plants is low, and the whitening and anti-aging effects they bring are also extremely limited. Technical issues

[0004] Regarding the above-mentioned related technologies, the inventors believe that for people with sensitive skin with damaged skin barriers, it is difficult for existing whitening and anti-aging products to achieve high-efficiency whitening and anti-aging while reducing irritation. Therefore, there is an urgent need to propose a solution to solve the above-mentioned technical problems. Technical Solutions

[0005] In order to obtain a low-irritation product suitable for people with sensitive skin with damaged skin barrier and capable of achieving excellent whitening and anti-aging effects, the present application provides a whitening and anti-aging composition and its preparation method and application.

[0006] In the first aspect, the present application provides a whitening and anti-aging composition, which adopts the following technical solution:

[0007] A whitening and anti-aging composition is prepared from the following raw materials in parts by weight:

[0008] 0.1-2 parts of hydroxypropyl cyclodextrin;

[0009] Tocopherol 0.1-2 parts;

[0010] 1-5 parts of emulsifier;

[0011] 0.5-1 part of preservative;

[0012] 1-5 parts of functional solvent;

[0013] Retinol 0.1-0.9 parts;

[0014] Adjust the mixed acid to 0.1-3 parts;

[0015] 90-100 parts of deionized water;

[0016] The regulating mixed acid agent consists of lactobionic acid, phytic acid and ferulic acid, and the weight ratio of lactobionic acid, phytic acid and ferulic acid is (5-7): (0.5-1):1.

[0017] By adopting the above technical solution, the combination of hydroxypropyl cyclodextrin and tocopherol can bring about moisturizing, whitening and anti-aging effects. During the application process, it can not only increase the skin's absorption of active substances and show a strong penetration-promoting effect, but also reduce the damage of oxidative stress to cells and regulate the metabolism of the skin during the absorption of effective ingredients, thereby achieving efficient whitening and anti-aging. For people with sensitive skin whose skin barrier is damaged, the combination of retinol and a regulating mixed acid can achieve efficient whitening and anti-aging while reducing irritation. Among them, retinol can increase skin elasticity and promote collagen production, thereby reducing dark spots and improving skin texture, and has an excellent effect in regulating skin metabolism. The regulating mixed acid composed of lactobionic acid, phytic acid and ferulic acid, in addition to its own whitening and anti-aging effects, can also be combined with retinol to bring different degrees of appropriate regulating effects on the skin's stratum corneum, transparent layer, granular layer, spinous layer, basal layer and dermis, thereby reducing the efficient irritation caused by itself and other effective ingredients to people with sensitive skin whose skin barrier is damaged. It can be seen that under the premise of the excellent compound effect of retinol and the regulating mixed acid, they can be combined with other raw materials to obtain a whitening and anti-aging composition that is low in irritation, suitable for people with sensitive skin whose skin barrier is damaged, and can achieve excellent whitening and anti-aging effects.

[0018] Preferably, the weight ratio of lactobionic acid, phytic acid and ferulic acid is 5:0.5:1.

[0019] By adopting the above technical solution, when lactobionic acid, phytic acid and ferulic acid in the above weight ratio are used in combination, they can not only exert excellent effects on their own and bring excellent whitening and anti-aging effects, but can also cooperate with retinol to exert better application effects, thereby making the obtained whitening and anti-aging composition more suitable for people with sensitive skin with damaged skin barrier, and exhibiting lower irritation and more efficient whitening and anti-aging effects.

[0020] Preferably, the weight ratio of the retinol to the regulating mixed acid agent is 1:7.

[0021] By adopting the above technical solution, when lactobionic acid, phytic acid, and ferulic acid are used in a specific weight ratio to form a regulating mixed acid agent, retinol and the regulating mixed acid agent in the above weight ratio can cooperate to exert a better application effect, can form a relatively excellent multi-level regulating effect on sensitive skin with damaged skin barrier, and have a better regulating effect on the stimulation brought by itself and other effective ingredients, thereby ensuring that the overall quality of the final whitening and anti-aging composition is also higher.

[0022] Preferably, the raw materials of the whitening and anti-aging composition further include 0.2-0.5 parts by weight of a functional regulator, wherein the functional regulator is composed of acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin, and the weight ratio of acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin is (0.1-0.3): (0.5-0.7):1.

[0023] By adopting the above technical solution, acetyl tetrapeptide-2 can upregulate the expression of genes related to collagen synthesis and focal adhesion, induce the synthesis of elastin and type I collagen, thereby increasing skin firmness and rebuilding the epidermal structure; hydrolyzed algin can keep the skin moisturized, repair damaged skin, and shrink pores to make the skin more delicate; fine algae polysaccharide can increase the skin's self-repair ability and bring moisturizing and antioxidant effects; and when acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin are used in a whitening and anti-aging composition according to a specific weight ratio to form a functional blending agent, the three components can bring about a complex synergistic effect. Acetyl tetrapeptide-2 is mainly internal, hydrolyzed algin is mainly external, and fine algae polysaccharide acts as a bridge to connect and coordinate the two inside and outside, achieving an effect from the outside to the inside and taking both inside and outside into consideration, thereby bringing about an outstanding effect of reducing the absorption stimulation of high-efficiency ingredients. The obtained whitening and anti-aging composition is not only more suitable for people with sensitive skin with damaged skin barrier, but also has a richer whitening and anti-aging system, and the whitening and anti-aging effect exerted by the application is also more excellent.

[0024] Preferably, the weight ratio of acetyl tetrapeptide-2, euglena polysaccharide and hydrolyzed algin is 0.2: 0.6: 1.

[0025] By adopting the above technical solution, the acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin in the above weight ratio can exert a better coordination effect during the application process, and form a strong response with retinol and the regulating mixed acid agent, thereby significantly improving the low stimulation and whitening and anti-aging effects, and the overall quality of the whitening and anti-aging composition is high.

[0026] Preferably, the functional solvent consists of caprylic / capric triglyceride and 1,2-hexanediol.

[0027] By adopting the above technical solution, caprylic acid / capric acid triglyceride has good hydrophilicity and lipophilicity, which can form a relatively stable binding state for the component raw materials; 1,2-hexanediol can disperse the various component raw materials; and the functional solvent composed of caprylic acid / capric acid triglyceride and 1,2-hexanediol is applied to the whitening and anti-aging composition, which can ensure that the various component raw materials can quickly cooperate with each other and exert excellent effects after application, thereby making the whitening and anti-aging composition more adaptable to people with sensitive skin with damaged skin barriers.

[0028] Preferably, the emulsifier is one or a combination of polysorbate-20, alkyl polyglucoside, arachidyl alcohol, lecithin and sorbitan oleate.

[0029] By adopting the above technical solution, the above types of emulsifiers are all suitable for the preparation of whitening and anti-aging compositions, and can form uniform dispersion and close combination between the various component raw materials, thereby ensuring that the coordination effect between the various raw materials is excellent and stable.

[0030] Preferably, the preservative is one or a combination of p-hydroxyacetophenone, phenoxyethanol, caprylyl glycol, sodium metabisulfite and butylated hydroxytoluene.

[0031] By adopting the above technical solution, the above types of preservatives can prevent or delay the growth of microorganisms and prevent the occurrence of spoilage components in the raw materials, thereby maintaining the stability of the properties of the whitening and anti-aging composition.

[0032] In a second aspect, the present application provides a method for preparing a whitening and anti-aging composition, which adopts the following technical solution:

[0033] A method for preparing a whitening and anti-aging composition comprises the following steps:

[0034] (1) Prepare raw materials including hydroxypropyl cyclodextrin, tocopherol, emulsifier, preservative, functional solvent, retinol, mixed acid adjusting agent and deionized water according to the ratio;

[0035] (2) dissolving the adjusted mixed acid in step (1) in a portion of deionized water to obtain a first phase material; simultaneously, adding hydroxypropyl cyclodextrin, an emulsifier, and retinol to the remaining deionized water, heating and dissolving the mixture to obtain a second phase material;

[0036] (3) The first phase material and the second phase material in step (2) are mixed and stirred, and tocopherol and a preservative are added during the process to obtain a whitening and anti-aging composition.

[0037] By adopting the above technical solution, the above preparation method is simple to operate and is convenient for large-scale industrial production. At the same time, during the operation, the first phase material and the second phase material are prepared separately, which facilitates quality control during the process, and hydroxypropyl cyclodextrin can protect unstable retinol, thereby ensuring that the obtained whitening and anti-aging composition has excellent and stable quality.

[0038] In a third aspect, the present application provides an application of a whitening and anti-aging composition in a whitening and anti-aging product, using the following technical solution:

[0039] A whitening and anti-aging composition is used in whitening and anti-aging products, wherein the whitening and anti-aging products include lotions, skin creams, skin creams, emulsions, essences, and facial masks.

[0040] By adopting the above technical solutions, the whitening and anti-aging compositions can be stably applied to the above-mentioned types of whitening and anti-aging products, and can be suitable for people with sensitive skin whose skin barrier is damaged. The overall composition has a variety of application forms and outstanding industrial application effects. Beneficial effects

[0041] In summary, this application has the following beneficial effects:

[0042] 1. The present invention utilizes retinol and a regulating mixed acid agent to provide varying degrees of appropriate regulating effects on the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum basale, and dermis, thereby reducing the high-efficiency irritation caused by retinol and other active ingredients to people with sensitive skin with damaged skin barriers. The resulting whitening and anti-aging composition can exert excellent whitening and anti-aging effects, is relatively mild overall, and is more suitable for people with sensitive skin with damaged skin barriers.

[0043] 2. This application adds a functional regulator composed of acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin, and utilizes the synergistic compounding effect brought by the three components, which not only achieves the effect of entering from the outside to the inside and taking both the inside and the outside into consideration, but also can bring about the outstanding effect of reducing the absorption stimulation of high-efficiency ingredients, and also makes the whitening and anti-aging system of the obtained whitening and anti-aging composition richer, and has better applicability for people with sensitive skin with damaged skin barrier. Modes for Carrying Out the Invention

[0044] The present application is further described in detail below with reference to the embodiments.

[0045] The raw materials used in the examples and comparative examples of this application all comply with the relevant requirements of the "Technical Specifications for Safety of Cosmetics". Example Example 1

[0046] A whitening and anti-aging composition, the raw materials used and their corresponding weight parts are shown in Table 1, and is prepared by the following method:

[0047] (1) Prepare raw materials including hydroxypropyl cyclodextrin, tocopherol, emulsifier, preservative, functional solvent, retinol, mixed acid adjusting agent and deionized water according to the ratio;

[0048] (2) dissolving the adjusted mixed acid in step (1) in 2 times the weight of deionized water to obtain a first phase material; simultaneously, adding hydroxypropyl cyclodextrin, emulsifier and retinol to the remaining deionized water, heating to 60° C. to dissolve, to obtain a second phase material;

[0049] (3) The first phase material and the second phase material in step (2) are mixed and stirred at a temperature of 40° C. and a stirring speed of 500 r / min. Tocopherol and preservatives are added during the process and stirring is continued for 10 minutes to obtain a whitening and anti-aging composition.

[0050] Note: In the above steps, the regulating mixed acid agent used is composed of lactobionic acid, phytic acid and ferulic acid in a weight ratio of 5:0.5:1; the emulsifier is polysorbate 20; the preservative is p-hydroxyacetophenone; and the functional solvent is composed of caprylic / capric triglyceride and 1,2-hexanediol in a weight ratio of 6:1.

[0051] Example 2-3

[0052] A whitening and anti-aging composition is different from Example 1 in that the raw materials used and their corresponding weight parts are as shown in Table 1.

[0053] Table 1 Raw materials used in the whitening and anti-aging compositions of Examples 1-3 and their weight parts (kg / part)

[0054] Raw Materials Example 1 Example 2 Example 3 Hydroxypropyl cyclodextrin 10.12 Tocopherol 120.1 Emulsifier 315 Preservative 0.750.51 Functional Solvent 315 Retinol 0.50.10.9 Adjusting Mixed Acid 1.530.1 Deionized Water 9590100

[0055] Example 4

[0056] A whitening and anti-aging composition, which differs from Example 1 in that the adjusted mixed acid agent is composed of lactobionic acid, phytic acid and ferulic acid in a weight ratio of 7:1:1. Example 5

[0057] A whitening and anti-aging composition, which differs from Example 1 in that the adjusted mixed acid agent is composed of lactobionic acid, phytic acid and ferulic acid in a weight ratio of 6:0.75:1. Example 6

[0058] A whitening and anti-aging composition is different from Example 1 in that the adjusting mixed acid agent is composed of lactobionic acid, phytic acid and ferulic acid in a weight ratio of 5.2:0.6:1. Example 7

[0059] A whitening and anti-aging composition is different from Example 1 in that the total amount of retinol and the regulating mixed acid agent remains unchanged, and the weight ratio of retinol to the regulating mixed acid agent is adjusted to 1:7. Example 8

[0060] A whitening and anti-aging composition is provided, which is different from Example 1 in that the functional solvent is composed of caprylic / capric triglyceride and 1,2-hexanediol in a weight ratio of 4:1. Example 9

[0061] A whitening and anti-aging composition, which differs from Example 8 in that caprylic / capric triglyceride is replaced by 1,2-hexanediol. Example 10

[0062] A whitening and anti-aging composition, which differs from Example 8 in that 1,2-hexanediol is replaced by caprylic / capric triglyceride. Example 11

[0063] A whitening and anti-aging composition, which differs from Example 1 in that 0.35 parts by weight of a functional regulator are further added to the raw materials of the whitening and anti-aging composition. The functional regulator is composed of acetyl tetrapeptide-2, fine algae polysaccharide, and hydrolyzed algin in a weight ratio of 0.2:0.6:1. In the preparation of the whitening and anti-aging composition, the functional regulator is added during the mixing and stirring of the first phase and the second phase. Example 12

[0064] A whitening and anti-aging composition, which is different from Example 11 in that the weight portion of the functional regulator added is 0.2 parts. Example 13

[0065] A whitening and anti-aging composition, which is different from Example 11 in that the functional regulator is added in an amount of 0.5 parts by weight. Example 14

[0066] A whitening and anti-aging composition, which differs from Example 11 in that the functional regulator is composed of acetyl tetrapeptide-2, fine algae polysaccharide, and hydrolyzed algin in a weight ratio of 0.1:0.5:1. Example 15

[0067] A whitening and anti-aging composition, which differs from Example 11 in that the functional regulator is composed of acetyl tetrapeptide-2, euglena polysaccharide, and hydrolyzed algin in a weight ratio of 0.3:0.7:1. Example 16

[0068] A whitening and anti-aging composition, which is different from Example 11 in that the raw materials do not contain acetyl tetrapeptide-2. Example 17

[0069] A whitening and anti-aging composition, which is different from Example 11 in that the raw materials do not contain fine algae polysaccharide. Example 18

[0070] A whitening and anti-aging composition, which is different from Example 11 in that the raw materials do not contain hydrolyzed algin. Example 19

[0071] A whitening and anti-aging composition, which is different from Example 11 in that the raw materials do not contain acetyl tetrapeptide-2 and fine algae polysaccharide. Example 20

[0072] A whitening and anti-aging composition, which is different from Example 11 in that the raw materials do not contain acetyl tetrapeptide-2 and hydrolyzed algin. Example 21

[0073] A whitening and anti-aging composition, which is different from Example 11 in that the raw materials do not contain fine algae polysaccharide and hydrolyzed algin. Comparative Example

[0074] Comparative Example 1

[0075] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain retinol.

[0076] Comparative Example 2

[0077] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain a regulating mixed acid agent.

[0078] Comparative Example 3

[0079] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain retinol and regulating mixed acid agent.

[0080] Comparative Example 4

[0081] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain lactobionic acid.

[0082] Comparative Example 5

[0083] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain phytic acid.

[0084] Comparative Example 6

[0085] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain ferulic acid.

[0086] Comparative Example 7

[0087] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain lactobionic acid and phytic acid.

[0088] Comparative Example 8

[0089] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain lactobionic acid and ferulic acid.

[0090] Comparative Example 9

[0091] A whitening and anti-aging composition, which is different from Example 1 in that the raw materials do not contain phytic acid and ferulic acid. Performance testing

[0092] Test samples: The whitening and anti-aging compositions obtained in Examples 1-21 were used as test samples 1-21, and the whitening and anti-aging compositions obtained in Comparative Examples 1-9 were used as control samples 1-9.

[0093] Test Method: 60 subjects with sensitive skin and damaged skin barriers, aged 20-35 years, were selected for the experiment and divided into 30 groups, with one male and one female in each group. Test samples 1-21 and control samples 1-9 were used respectively. Before using the whitening and anti-aging composition, the test subjects performed a simple facial cleansing. A 3cm*3cm non-woven membrane cloth soaked with 0.5ml of the whitening and anti-aging composition was applied to the test subject's face for 10 minutes, once at 9:00 am and once at 6:00 pm, and the same skin location was covered. After 7 consecutive days, the following test was conducted:

[0094] (1) Transepidermal water loss (TEWL) change test: Transepidermal water loss (TEWL), also known as transdermal water loss, refers to the loss of water from the deep dermis through evaporation of the epidermis. It is an important parameter for describing the skin barrier. The lower the TEWL rate, the stronger the skin barrier ability and the less sensitive the skin. The German CK skin tester Tewameter TM Hex was used to measure the TEWL of the test subjects before using the whitening and anti-aging composition, which was recorded as the initial value. After using the composition for 7 consecutive days, the TEWL was measured again, which was recorded as the end value. Finally, the change rate of TEWL was calculated, which is the change rate = (initial value - end value) / initial value. The greater the change rate, the better the effect of the whitening and anti-aging composition.

[0095] (2) Hemoglobin content change test: After the skin barrier is damaged, the capillaries under the stratum corneum are easily exposed. Due to external stimulation, the capillaries will expand and fill, causing the skin to become red. After using cosmetics, the lower the hemoglobin content, the less irritation the skin is exposed to. The German CK skin hemoglobin tester Mexameter MX18 is used to measure the hemoglobin content of the tester before using the whitening and anti-aging composition. The initial value is recorded. After 7 days of continuous use, the hemoglobin content is measured again. The end value is recorded. Finally, the change rate of the hemoglobin content is calculated. The change rate = (initial value - end value) / initial value. The greater the change rate, the better the effect of the whitening and anti-aging composition.

[0096] (3) Wrinkle area change test: The wrinkle area ratio is often used to reflect the anti-aging effect of cosmetics. The smaller the value, the less wrinkles there are, and the better the anti-wrinkle effect. The American facial image analyzer VISIA-CR is used to measure the wrinkle area of ​​the test subjects before using the whitening and anti-aging composition, which is recorded as the initial value. After using it for 7 consecutive days, the wrinkle area is measured again, which is recorded as the end value. Finally, the change rate of the wrinkle area is calculated, which is the change rate = (initial value - end value) / initial value. The larger the change rate, the better the effect of the whitening and anti-aging composition.

[0097] (4) Skin whitening effect test: The tyrosinase activity detection method in the relevant literature was used. The referenced literature is Song Qiru, Huang Lei, Jin Xipeng's Biochemical Enzymology Determination of Tyrosinase Activity in Cells [J]. Surfactant Chemical Industry, 2001, 4 (8): 52-53. Based on the principle of spectral absorption, the melanin content in the skin was determined by the amount of reflection after a specific wavelength of light was irradiated on the human skin using an autologous melanocyte detector. The tester measured the melanin content before using the whitening and anti-aging composition, which was recorded as the initial value. After using it for 7 consecutive days, the melanin content was measured again, which was recorded as the end value. Finally, the change rate of the melanin content was calculated, which is the change rate = (initial value - end value) / initial value. The greater the change rate, the better the effect of the whitening and anti-aging composition.

[0098] Table 2 Application test results of test samples 1-21 and control samples 1-9

[0099] Change rate of transepidermal water loss of sample skin (%) Change rate of hemoglobin content (%) Change rate of wrinkle area (%) Change rate of melanin content (%) Test sample 1 20.12 10.55 11.32 12.45 Test sample 2 19.95 10.43 11.17 12.27 Test sample 3 19.87 10.48 11.24 12.35 Test sample 4 19.56 10.45 11.13 12.31 Test sample 5 19.67 10.51 11.15 12.24 Test sample 6 19.75 10.40 11.10 12 .39 Test sample 7 20.31 10.89 11.57 12.67 Test sample 8 20.08 10.53 11.29 12.42 Test sample 9 19.23 10.31 10.87 11.94 Test sample 10 19.41 10.28 10.92 12.06 Test sample 11 27.24 14.71 16.54 18.71 Test sample 12 27.13 14.64 16.46 18.64 Test sample 13 27.19 14.68 16.49 18.67 Test sample 14 27.11 14.6 216.4318.61 Test sample 1527.2014.6516.5118.69 Test sample 1622.9812.3113.3214.88 Test sample 1722.7712.2013.2314.71 Test sample 1822.6112.0813.0914.56 Test sample 1921.6311.4912.3913.74 Test sample 2021.4711.3712.2513.59 Test sample 2121.2611.2612.1613.42 Control sample 113.233.757.799.06Control sample 213.59-0.428.119.35Control sample 311.45-3.216.177.23Control sample 414.113.128.609.99Control sample 514.183.238.6810.07Control sample 614.142.958.579.93Control sample 713.871.498.419.73Control sample 813.831.218.309.62Control sample 913.901.328.389.69

[0100] Combining Example 1 and Comparative Examples 1-3 with Table 2, it can be seen that the combination of retinol and the regulating mixed acid agent can achieve a synergistic effect, so that the obtained whitening and anti-aging composition performs more prominently in the performance of the change rate of transepidermal water loss, the change rate of hemoglobin content, the change rate of wrinkle area, and the change rate of melanin content; while using retinol or the regulating mixed acid agent alone can also bring about the improvement of the above-mentioned effects, the sum of the improvement is far less than the excellent combination of the two, and when the whitening and anti-aging composition lacks the combination of retinol and the regulating mixed acid agent, it will cause the other effective ingredients to cause a certain irritation to sensitive skin with damaged skin barrier. Combined with Comparative Examples 4-9 and Table 2, it can be seen that the regulating mixed acid agent composed of lactobionic acid, phytic acid, and ferulic acid has strong applicability to sensitive skin with damaged skin barrier, and can exert excellent effects in combination with retinol. However, if any one or two of lactobionic acid, phytic acid, and ferulic acid are used as the regulating mixed acid agent, the effect exerted in combination with retinol is limited.

[0101] From Example 1 and Examples 4-6 and Table 2, it can be seen that when the weight ratio of lactobionic acid, phytic acid, and ferulic acid is 2:2:1, they can cooperate with retinol to achieve a better application effect, so that the resulting whitening and anti-aging composition exhibits lower irritation when used, and has a more efficient whitening and anti-aging effect.

[0102] From Examples 1-3 and Example 7 in conjunction with Table 2, it can be seen that when lactobionic acid, phytic acid, and ferulic acid are used in a specific weight ratio to form a regulating mixed acid agent, and retinol and the regulating mixed acid agent are used in a weight ratio of 1:3, the resulting whitening and anti-aging composition can have a higher application quality.

[0103] From Example 1 and Examples 8-10 and Table 2, it can be seen that when the solvent is composed of caprylic / capric triglyceride and 1,2-hexanediol, the component raw materials can be evenly dispersed and form a relatively stable binding state, thereby making the whitening and anti-aging composition more adaptable to people with sensitive skin with damaged skin barrier, and the performance of the change rate of transepidermal water loss, the change rate of hemoglobin content, the change rate of wrinkle area and the change rate of melanin content are relatively stable; if caprylic / capric triglyceride or 1,2-hexanediol is used alone, the application effect of the whitening and anti-aging composition will be significantly damaged.

[0104] Combining Example 1 and Examples 11-15 with Table 2, it can be seen that the application of the functional blending agent composed of acetyl tetrapeptide-2, euglena polysaccharide and hydrolyzed algin in the whitening and anti-aging composition can further improve the performance of the change rate of transepidermal water loss, the change rate of hemoglobin content, the change rate of wrinkle area and the change rate of melanin content. When the weight ratio of acetyl tetrapeptide-2, euglena polysaccharide and hydrolyzed algin is 0.2: 0.6: 1, the improvement effect brought by the application is better. Combined with Examples 16-24 and Table 2, it can be seen that if any one or two of acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin are applied to the whitening and anti-aging composition, the lifting effect is limited and far inferior to the excellent lifting effect brought by the combination of the three. At the same time, it can also be seen that the combination of acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin is not a simple superposition, and the three have a synergistic effect of compounding, which can bring about an outstanding effect of reducing the absorption stimulation of high-efficiency ingredients. The obtained whitening and anti-aging composition is not only more suitable for people with sensitive skin with damaged skin barrier, but also can exert a more excellent whitening and anti-aging effect.

[0105] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A whitening and anti-aging composition, characterized in that: Made from the following raw materials in parts by weight: 0.1-2 parts of hydroxypropyl cyclodextrin; Tocopherol 0.1-2 parts; 1-5 parts of emulsifier; 0.5-1 part of preservative; 1-5 parts of functional solvent; Retinol 0.1-0.9 parts; Adjust the mixed acid to 0.1-3 parts; 90-100 parts of deionized water; The regulating mixed acid agent consists of lactobionic acid, phytic acid and ferulic acid, and the weight ratio of lactobionic acid, phytic acid and ferulic acid is (5-7): (0.5-1):

1.

2. The whitening and anti-aging composition according to claim 1, characterized in that: The weight ratio of the lactobionic acid, phytic acid and ferulic acid is 5:0.5:

1.

3. The whitening and anti-aging composition according to claim 2, characterized in that: The weight ratio of the retinol to the regulating mixed acid agent is 1:

7.

4. The whitening and anti-aging composition according to claim 1, characterized in that: The raw materials of the whitening and anti-aging composition are further added with 0.2-0.5 parts by weight of a functional regulator, wherein the functional regulator is composed of acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin, and the weight ratio of acetyl tetrapeptide-2, fine algae polysaccharide and hydrolyzed algin is (0.1-0.3): (0.5-0.7):

1.

5. The whitening and anti-aging composition according to claim 4, characterized in that: The weight ratio of the acetyl tetrapeptide-2, the fine algae polysaccharide and the hydrolyzed algin is 0.2: 0.6:

1.

6. The whitening and anti-aging composition according to claim 1, characterized in that: The functional solvent consists of caprylic / capric triglyceride and 1,2-hexanediol.

7. The whitening and anti-aging composition according to claim 1, characterized in that: The emulsifier is one or a combination of polysorbate-20, alkyl polyglucoside, arachidyl alcohol, lecithin and sorbitan oleate.

8. The whitening and anti-aging composition according to claim 1, characterized in that: The preservative is one or a combination of p-hydroxyacetophenone, phenoxyethanol, caprylyl glycol, sodium metabisulfite and butylated hydroxytoluene.

9. The method for preparing the whitening and anti-aging composition according to claim 1, characterized in that: The following steps are involved: (1) Prepare raw materials including hydroxypropyl cyclodextrin, tocopherol, emulsifier, preservative, functional solvent, retinol, mixed acid adjusting agent and deionized water according to the ratio; (2) dissolving the adjusted mixed acid in step (1) in a portion of deionized water to obtain a first phase material; simultaneously, adding hydroxypropyl cyclodextrin, an emulsifier, and retinol to the remaining deionized water, heating and dissolving the mixture to obtain a second phase material; (3) The first phase material and the second phase material in step (2) are mixed and stirred, and tocopherol and a preservative are added during the process to obtain a whitening and anti-aging composition.

10. Use of the whitening and anti-aging composition according to any one of claims 1 to 8 in whitening and anti-aging products, characterized in that: The whitening and anti-aging products include lotions, skin creams, skin creams, emulsions, essences and facial masks.