Intraocular lens device, intraocular lens system, and methods of using the same

Abstract

An intraocular lens device comprising an annular body portion comprising an anterior portion having an anterior opening, a posterior portion having a posterior opening, a lateral portion interposed between the anterior portion and the posterior portion; and a plurality of haptics extending from the anterior portion of the annular body; the anterior opening and the posterior opening are radially centered along an optical axis, the lateral portion comprises a plurality of lateral openings perpendicular to the optical axis, and a method of implanting an intraocular lens using the same intraocular lens device.

Description

INTRAOCULAR LENS DEVICE, INTRAOCULAR LENS SYSTEM, AND METHODS OF USING THE SAME1. CROSS REFERENCE

[0001] This application claims the benefit of priority from U.S. Provisional Application No. 63 / 573,217, filed April 2, 2024, and U.S. Provisional Application No. 63 / 684,074, filed August 16, 2024. Each of the foregoing related applications, in its entirety, is incorporated herein by reference.2. FIELD

[0002] Provided herein relates to an intraocular lens device, an intraocular lens system, and methods for insertion into an eye.3. SUMMARY

[0003] Provided herein is an intraocular lens device, comprising: i) an annular body comprising: a) an anterior portion comprising an anterior opening radially centered along an optical axis; and b) a posterior portion comprising a posterior opening radially centered along the optical axis; wherein the anterior portion and the posterior portion meet at a plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening; and ii) a plurality of haptics attached to the anterior portion.

[0004] In another aspect, provided herein is an intraocular lens device, comprising: i) an annular body portion: a) an anterior portion comprising an anterior opening radially centered along an optical axis; b) a posterior portion comprising a posterior opening radially centered along the optical axis; and c) a lateral portion interposed between the anterior portion and the posterior portion, wherein the lateral portion protrudes radially beyond the anterior portion and the posterior portion; and ii) a plurality of haptics extending from the anterior portion of the annular body.

[0005] In another aspect, provided herein is an intraocular lens device, comprising: i) an annular body portion: a) an anterior opening radially centered along an optical axis; b) a posterior opening radially centered along an optical axis; and c) a lateral portion extending from the anterior opening to the posterior opening, wherein the lateral portion protrudes radially beyond the anterior opening and the posterior opening; and ii) a plurality of haptics extending from an anterior portion of the lateral portion of the annular body.

[0006] In another aspect, provided herein is an intraocular lens device, comprising: i) an annular body portion comprising an anterior portion comprising an anterior opening, aposterior portion comprising a posterior opening, and a lateral portion interposed between the anterior portion and the posterior portion; and ii) a plurality of haptics extending from the anterior portion of the annular body; wherein: a) the anterior opening and the posterior opening are radially centered along an optical axis, b) the anterior opening is larger than the posterior opening, and c) the lateral portion comprises a plurality of lateral openings (sometimes referred to as lateral ports) perpendicular to the optical axis.

[0007] In another aspect, provided herein is an intraocular lens device, comprising: i) an intraocular ring that is radially centered along an optical axis; ii) a plurality of haptics extending from the intraocular ring; and iii) a plurality of loops extending from the intraocular ring and substantially perpendicular to the optical axis.

[0008] In another aspect, provided herein is an intraocular lens device, comprising: i) an intraocular ring that is radially centered along an optical axis; ii) a plurality of haptics extending from the intraocular ring; and iii) a plurality of nodes arranged around the intraocular ring; wherein the intraocular ring comprises a continuous recess, a plurality of perforations, or a plurality of slits, or combinations thereof, along a circumference of the intraocular ring.

[0009] In another aspect, provided herein is an intraocular lens system, comprising an intraocular lens (IOL) within the cavity of the intraocular lens device as disclosed herein.

[0010] In another aspect, provided herein is a method of implanting an intraocular lens (IOL) into the eye of a subject, comprising: i) injecting the intraocular lens device as disclosed herein into an eye of a subject; optionally into a capsular bag of an eye of a subject; and ii) injecting an intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

[0011] In another aspect, provided herein is a method of implanting an intraocular lens (IOL) into the eye of a subject, comprising injecting the intraocular lens system as disclosed herein.

[0012] In another aspect, provided herein is a method of forming an opening sufficient for insertion of an IOL haptic, comprising piercing or opening a portion of the continuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring of the intraocular lens device as disclosed herein.

[0013] In another aspect, provided herein is a method of preparing the intraocular lens system as disclosed herein, comprising piercing or opening a portion of the continuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring of said intraocular lens device sufficient to insert an IOLhaptic.4. BRIEF DESCRIPTION OF THE FIGURES

[0014] FIG. 1A depicts anterior oblique views of the intraocular lens (IOL) device 100 having an annular body 102A.

[0015] FIG. IB depicts anterior oblique views of the intraocular lens (IOL) device 100 having an annular body 102B.

[0016] FIG. 2A depict anterior oblique views of the intraocular lens (IOL) system 200 having an annular body 102A.

[0017] FIG. 2B depict anterior oblique views of the intraocular lens (IOL) system 200 having an annular body 102C.

[0018] FIG. 3A depicts an anterior plan view of the intraocular lens (IOL) device 100.

[0019] FIG. 3B depicts a cross-sectional side view of the intraocular lens (IOL) device100

[0020] FIG. 3C depicts a posterior plan view of the intraocular lens (IOL) device 100.

[0021] FIG. 4A depicts an anterior plan view of an intraocular lens (IOL) system 200.

[0022] FIG. 4B depicts a cross-sectional side view of the intraocular lens (IOL) system200.

[0023] FIGS. 5A, 5B, 5C, and 5D depict anterior oblique views of intraocular lens (IOL) devices with lateral opening variations 500.

[0024] FIG. 6A depicts an anterior plan view of an intraocular lens (IOL) system 600.

[0025] FIG. 6B depicts a cross-sectional side view of the intraocular lens (IOL) system600.

[0026] FIG. 7A depicts an anterior plan view of an intraocular lens (IOL) system 700.

[0027] FIG. 7B depicts a cross-sectional side view of the intraocular lens (IOL) system700.

[0028] FIG. 8A depicts an anterior oblique view of the intraocular lens (IOL) device 800.

[0029] FIG. 8B depicts an anterior plan view of the intraocular lens (IOL) device 800.

[0030] FIG. 8C depicts a cross-sectional side view of the intraocular lens (IOL) device 800.

[0031] FIG. 9A depicts an anterior oblique view of the intraocular lens (IOL) device 900.

[0032] FIG. 9B depicts an anterior plan view of the intraocular lens (IOL) device 900.

[0033] FIG. 9C depicts a cross-sectional side view of the intraocular lens (IOL) device 900.

[0034] FIG. 10A depicts an anterior oblique view of the intraocular lens (IOL) device 1000

[0035] FIG. 10B depicts an anterior plan view of the intraocular lens (IOL) device 1000.

[0036] FIG. 10C depicts a cross-sectional side view of the intraocular lens (IOL) device1000

[0037] FIG. 11A depicts an anterior oblique view of the intraocular lens (IOL) device 1100

[0038] FIG. 11B depicts an anterior plan view of the intraocular lens (IOL) device 1100.

[0039] FIG. 11C depicts a cross-sectional side view of the intraocular lens (IOL) device1100

[0040] FIG. 12 is a diagrammatic cross-sectional side view of an eye 1202 into which an IOL system 1200 has been implanted.

[0041] FIG. 13A depicts a close-up, cross-sectional view of an eye implanted with an IOL system 1200 from an anterior oblique perspective.

[0042] FIG. 13B depicts a close-up, cross-sectional sideview of an eye implanted with an IOL system 1200.

[0043] FIG. 14A depicts an anterior plan view of an intraocular lens (IOL) system 200.

[0044] FIG. 14B depicts an anterior plan view of an implanted intraocular lens (IOL) system 1200.

[0045] FIG. 15 depicts an anterior plan view of an intraocular lens (IOL) device 1500 with elongated haptics 110A.

[0046] FIG. 16A depicts anterior plan views of an intraocular lens (IOL) device 1600 with three haptics 110.

[0047] FIG. 16B depicts anterior plan views of an intraocular lens (IOL) device 1600 with four haptics 110.

[0048] FIG. 17 depicts an anterior plan view of an intraocular lens (IOL) device 1700 with four petal-shaped haptics HOB.

[0049] FIG. 18 depicts an anterior plan view of an intraocular lens (IOL) device 1800 with haptics HOC containing eyelets 1802.

[0050] FIG. 19 depicts an anterior plan view of an intraocular lens (IOL) device 1900 with haptics HOD containing attachment points 1902.

[0051] FIG. 20A depicts a de-roofed needle 2000 with a de-roofed portion 2002 and enclosed endpoints.

[0052] FIG. 20B depicts a de-roofed needle 2000 with a de-roofed portion 2002 and ade-roofed endpoint.

[0053] FIG. 21 depicts a close-up, cross-sectional view of an eye 2100 implanted with the de-roofed needle 2000 from an anterior oblique perspective.

[0054] FIG. 22 depicts an anterior plan view of an eye 2200 implanted with the deroofed needle 2000 that has been threaded with anchor threads 2202.

[0055] FIG. 23 depicts an anterior plan view of an eye 2300 implanted with an intraocular lens (IOL) device 1900 with haptics HOD containing attachment points 1902.

[0056] FIG. 24 depicts an anterior plan view of an eye 2400 implanted with an intraocular lens (IOL) device 1900 with haptics HOD that have been externalized and fastened with fasteners 2404.

[0057] FIG. 25A depicts an anterior view of a prototype of intraocular lens (IOL) device 100 having an annular body 102A.

[0058] FIGS. 25B and 25C depict lateral views of a prototype of intraocular lens (IOL) system 100 having an annular body 102A.

[0059] FIG. 26A depicts an anterior oblique view of the intraocular lens (IOL) device 2600 having an interocular ring 2601.

[0060] FIG. 26B depicts an anterior oblique view of the intraocular lens (IOL) system 2600 having an interocular ring 2601.

[0061] FIG. 26C depicts an anterior view of the intraocular lens (IOL) system 2600 having an interocular ring 2601.

[0062] FIG. 26D depicts a cross-sectional side view of the intraocular lens (IOL) system 2600.

[0063] FIG. 27A depicts an anterior oblique view of the intraocular lens (IOL) device 2700 having an interocular ring 2701.

[0064] FIG. 27B depicts an anterior oblique view of the intraocular lens (IOL) system 2700 having an interocular ring 2701.

[0065] FIG. 27C depicts an anterior view of the intraocular lens (IOL) system 2700 having an interocular ring 2701.

[0066] FIG. 27D depicts a cross-sectional side view of the intraocular lens (IOL) system 2700.

[0067] FIG. 27E depicts an expanded view of the interocular ring 2701 of intraocular lens (IOL) device 2700.

[0068] FIG. 28A depicts an anterior oblique view of the intraocular lens (IOL) device 2800 having an interocular ring 2801.

[0069] FIG. 28B depicts an anterior oblique view of the intraocular lens (IOL) system 2800 having an interocular ring 2801.

[0070] FIG. 29A depicts an anterior oblique view of the intraocular lens (IOL) device 2900 having an interocular ring 2901.

[0071] FIG. 29B depicts an anterior oblique view of the intraocular lens (IOL) system 2900 having an interocular ring 2901.5. DETAILED DESCRIPTION

[0072] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of ordinary skill in the art. All patents, applications, published applications and other publications are incorporated by reference in their entirety. In the event that there are a plurality of definitions for a term herein, those in this section prevail unless stated otherwise.

[0073] As used herein, and in the specification and the accompanying claims, the indefinite articles “a” and “an” and the definite article “the” include plural as well as single referents, unless the context clearly indicates otherwise.

[0074] As used herein, and unless otherwise specified, the term “about” when used in connection with a measured value, for example, a length, angle, tensile strength, weight, indicate that the value or range of values may deviate to an extent deemed reasonable to one of ordinary skill in the art while still describing the particular device or system feature. For example, in particular embodiments, the term “about” when used in this context, indicate that the numeric value or range of values may vary within 25%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1.5%, 1%, 0.5%, or 0.25% of the recited value or range of values.

[0075] As used herein, the term “subject” to which administration or treatment is contemplated, can be an animal, including, but not limited to, a human (e.g., a male or female of any age group, such as an adult subject or an adolescent subject); a primate (e.g., cynomolgus monkey, rhesus monkey), and / or another mammal, including a commercially relevant mammal such as cattle, pig, horse, sheep, goat, cat, dog, rabbit, rodent, and / or bird. In some embodiments, the subject is a mammal. In some embodiments, the subject is a human. In some embodiments, the subject is a patient, such as a human patient. In some embodiments, the subject is an adolescent human. In some embodiments, the subject is an adult human.

[0076] The incidence of a posterior capsular tear occurring during cataract surgery is around 0.45% to 5% of cataract surgeries. The current standard for treatment of a posteriorcapsular tear is to perform an anterior vitrectomy on the affected eye, followed by implantation of a 3 -piece non-toric monofocal intraocular lens (IOL) within the sulcus of the affected eye. This surgical response is suboptimal for multiple reasons. For instance, instead of a planned single piece IOL being inserted a 3 -piece IOL has to be implanted within the sulcus. The latter’s power needs to be altered at the time of surgery to account for the more anterior implantation i.e in the sulcus instead of the capsular bag. This adds to the stress of the surgeon during an already stressful situation and surgeons can potentially make a calculation error. The refractive outcome becomes less predictable compared with the capsular bag implantation. Monofocal non-toric 3 piece IOLS do not correct astigmatism and do not offer multifocality. As a result, some surgeons outright refuse to perform presbyopia correcting IOL (PCIOL) surgeries as there are currently no multifocal 3 piece IOL. This problem could be overcome by producing multifocal or presbyopia correcting 3-piece IOLs. However, a large stock would have to be maintained of different powers for different eyes for sporadic emergency use. Since the product is used infrequently, manufacturers have discontinued production of 3-piece multifocal IOLs to save cost. Astigmatic correction was never incorporated into the 3-piece IOLs. Therefore, in a case where posterior capsular tear occurs the patient cannot have their astigmatic error corrected affecting their distance and near vision.

[0077] Once a 3 piece non-toric monofocal IOL is implanted in the sulcus it restricts the surgical options for correcting residual spherical and astigmatic refractive error. For example, a secondary IOL cannot be implanted in the sulcus due to a lack of available space. Laser treatments (e.g., LRI, LASIK, PRK, etc.) can be sufficiently noninvasive, but high equipment costs associated with these procedures make these types of treatments prohibitive for many eye surgeons. Furthermore, astigmatism related to complications from cataract surgery can produce a residual astigmatism that may exceed the treatment capacity of refractive lasers. Additionally, if a presbyopia correcting i.e. multifocal IOL is implanted in the first eye and a posterior capsular tear occurs in the second eye then the patient is caught with different IOL models in each eye.

[0078] The IOL device disclosed herein provide an implantation solution that is specifically designed for implantation following a posterior capsular tear. For example, the IOL device disclosed herein is configured for placement within a dedicated position (i.e. posterior to the anterior capsule), similar to the effective positioning that is achieved in the presence of an intact capsular bag. Surgeons would therefore be able to achieve consistent, reliable results that are congruous with preoperative calculations and planning, therebyeliminating or substantially reducing the need for real-time adaption, recalculation, and / or arrangement of a backup IOL that most likely results in an inferior outcome for the patient.

[0079] In some embodiments, the IOL device disclosed herein is similar in design with the most popular 3 piece monofocal IOLS on the market, including the MA60AC IOL (registered product of Alcon Surgical). This shortens the learning curve for adoption by surgeons, who are generally already familiar with the most popular 3 piece monofocal rescue IOLs including the MA60AC IOL. Furthermore, the flexibility of the IOL device disclosed herein means that utilization of the MA60AC IOL may actually decrease. For example, currently a stock of 50 3-piece IOLs such MA60AC (registered product of Alcon Surgical) IOLs spanning all possible eye prescriptions (+6D to +30D at +0.5 steps) needs to be constantly maintained by surgery centers as a backup in case of a posterior capsular tear. This quantity is disproportional to the actual incidence rate of posterior capsular tears. In some embodiments, because the IOL device disclosed herein can accept varying sizes / shapes of IOLs and / or multiple IOLs, surgery centers no longer need to maintain the aforementioned library of MA60AC IOLs, and may instead maintain a supply of just 2-4 of the IOL device disclosed herein and use the planned single piece IOL. As another consequence of this flexibility, a lack of the correct MA60AC IOL for a given patient will not result in a postponement of a scheduled surgery or require a follow-up procedure for cylinder correction. This may also result in an increase in PCIOL surgeries.

[0080] The design of the IOL device disclosed herein is highly accommodating of surgical manipulations. For example, in some embodiments, the fenestrated and / or reticulated design of the IOL device disclosed herein enables an uncompromised view of the posterior chamber by the surgeon. This means an anterior vitrectomy can continue to be performed even if more vitreous is encountered during the procedure than anticipated. Furthermore, post-surgery, this poses no risk of capsular contraction, since by definition the capsule cannot phimose following a posterior capsular tear. In some embodiments, the IOL device disclosed herein can also be used to keep open and / or support an intact capsular bag.

[0081] In some embodiments, the IOL device disclosed herein is also useful in surgical treatments for aphakia. For example, in some embodiments, the haptics of the IOL device can be extravasated and anchored to the sclera, allowing a toric IOL and / or PCIOL to be inserted.

[0082] In some embodiments, the IOL device disclosed herein is useful in treatments of age-related macular degeneration (AMD) and / or glaucoma.

[0083] In some embodiments, provided herein is an intraocular lens device, comprising:i) an annular body comprising: a) an anterior portion comprising an anterior opening radially centered along an optical axis; and b) a posterior portion comprising a posterior opening radially centered along the optical axis; wherein the anterior portion and the posterior portion meet at a plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening; and ii) a plurality of haptics attached to the anterior portion.

[0084] In some embodiments, provided herein is an intraocular lens device, comprising: i) an annular body portion: a) an anterior portion comprising an anterior opening radially centered along an optical axis; b) a posterior portion comprising a posterior opening radially centered along the optical axis; and c) a lateral portion interposed between the anterior portion and the posterior portion, wherein the lateral portion protrudes radially beyond the anterior portion and the posterior portion; and ii) a plurality of haptics extending from the anterior portion of the annular body.

[0085] In some embodiments, provided herein is an intraocular lens device, comprising: i) an annular body portion: a) an anterior opening radially centered along an optical axis; b) a posterior opening radially centered along an optical axis; and c) a lateral portion extending from the anterior opening to the posterior opening, wherein the lateral portion protrudes radially beyond the anterior opening and the posterior opening; and ii) a plurality of haptics extending from an anterior portion of the lateral portion of the annular body.

[0086] In some embodiments, provided herein is an intraocular lens device, comprising: i) an annular body portion comprising an anterior portion comprising an anterior opening, a posterior portion comprising a posterior opening, and a lateral portion interposed between the anterior portion and the posterior portion; and ii) a plurality of haptics extending from the anterior portion of the annular body; wherein: a) the anterior opening and the posterior opening are radially centered along an optical axis, b) the anterior opening is larger than the posterior opening, and c) the lateral portion comprises a plurality of lateral openings perpendicular to the optical axis.

[0087] In some embodiments, the IOL device disclosed herein is sized and shaped for implantation into the capsular bag of an ophthalmic patient’s eye. In some embodiments, the intraocular lens device is configured to be inserted inside the capsular bag of an eye. In some embodiments, the capsular bag can also be implanted after removal of a lens, such as during surgery to treat cataracts. In some embodiments, the IOL device is further configured to be inserted into an eye as a replacement capsular bag / prosthetic capsular device. This may involve an alternative surgical procedure that includes suturing eyelets embedded within the device haptics to the subject’s eye. The haptics or part of the haptic may be extravasated fromthe eye through an opening in the sclera or a suture can be passed through the eyelet and externalized through the sclera to anchor the device to the scleral wall in situations where there is partial or total zonular loss. In some embodiments, the IOL device disclosed herein is cross-compatible for implantation in both diseased, pathological, tom, and / or weakened capsular bags, as well as healthy, intact, or otherwise functional capsular bags.

[0088] In some embodiments, the IOL device comprises a single-molded design. In other words, the whole device, or substantially the whole device other than the lens or refractive surface and / or one or more haptics, can be molded from a single piece of material. In some embodiments, the whole IOL device, or substantially the whole IOL device, can be molded from a single piece of biocompatible material. In some embodiments, the annular body and the plurality of haptics of the IOL device disclosed herein is molded from a single piece of biocompatible material. In some embodiments, the biocompatible material is PMMA, silicone, acrylic, such as hydrophilic acrylic or hydrophobic acrylic, silicone, such as hydrophilic silicone or hydrophobic silicone, some other biocompatible hydrophobic or hydrophilic material, or a combination thereof. For example, in some embodiments, the whole IOL device, or substantially the whole IOL device, can be molded from a single piece of PMMA, silicone, acrylic, some other biocompatible hydrophobic or hydrophilic material, or a combination thereof. For example, in some embodiments, the whole device, or substantially the whole device can be molded of poly(methyl-methacrylate) (sometimes referred to as PMMA) using a poly(methyl-methacrylate) compression mold. In other embodiments, the device or any portion thereof can be manufactured by 3D laser cutting, two photon lithography, additive manufacturing, 3D printing, compression molding, and / or any combination of the aforementioned manufacturing processes or others. In some embodiments, the IOL device comprises a single-molded design, whereby the IOL device is capable of being molded from a single piece of material. In some embodiments, the device comprises poly(methyl-methacrylate). In some embodiments, the IOL device disclosed herein is flexible in order to accommodate varying sizes of IOLS. In some embodiments, the IOL device disclosed herein is flexible enough to be loaded into a cartridge for implantation. In some embodiments, the IOL device may have an anti-lens epithelial cell proliferation coating and / or the IOL device may comprise of a material which allows removal of proliferating cells.

[0089] In some embodiments of the IOL device disclosed herein, the annular body has radial symmetry, a ring shape, a substantially prolate spheroid shape, a substantially ellipsoidal shape, or a substantially toroid shape. In some embodiments, the annular body issubstantially donut-shaped or substantially tire-shaped. In some embodiments, the annular body is bilaterally symmetrical across a plane perpendicular to the optical axis. In some embodiments, annular body is bilaterally symmetrical across at least one plane dividing the anterior and posterior openings. In some embodiments, the annular body is bilaterally symmetrical across at least one plane parallel to the anterior and posterior openings. In some embodiments, the annular body has a mesh surface. In some embodiments, the annular body has a smooth surface. In some embodiments, the annular body has a smooth, continuous surface. In some embodiments, the annular body has a non-porous surface.

[0090] In some embodiments of the IOL device disclosed herein, the height of the annular body along the optical axis is in the range of between about 1.5-3.5 mm. For example, in some embodiments, the height of the annular body along the optical axis is in the range of between about 1.5-2.0 mm, about 1.5-2.5 mm, about 2.0-2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, or about 3.0-3.5 mm, such as in the range of between about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, or about 3.5 mm.

[0091] In some embodiments of the IOL device disclosed herein, the anterior portion of the annular body has radial symmetry. In some embodiments, the anterior portion is domed. In some embodiments, the anterior portion is curvilinear. In some embodiments, the anterior portion is arcuate. In some embodiments, the anterior portion extends from the plane substantially at the midpoint of the annular body and terminates at the anterior opening. In some embodiments, the anterior portion is tapered towards the anterior opening.

[0092] In some embodiments of the IOL device disclosed herein, the posterior portion of the annular body has radial symmetry. In some embodiments, the posterior portion is domed. In some embodiments, the posterior portion is curvilinear. In some embodiments, the posterior portion is arcuate. In some embodiments, the posterior portion extends from the plane substantially at the midpoint of the annular body and terminates at the posterior opening. In some embodiments, the posterior portion is tapered towards the posterior opening. In some embodiments, the annular body is symmetrical over the plane at a midpoint between the anterior portion and the posterior portion. In some embodiments, the annular body is not symmetrical over the plane at a midpoint between the anterior portion and the posterior portion.

[0093] In some embodiments of the IOL device disclosed herein, the annular body comprises a transition dividing the anterior portion and the posterior portion. In some embodiments, the transition point comprises an outermost diameter of the annular body. In some embodiments, the annular body at the plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening comprises an outermost diameter of the annular body. In some embodiments, the portion of the annular body where the anterior portion and the posterior portion meet substantially at the plane at the midpoint of the annular body between the anterior opening and the posterior opening is a lateral portion. In some embodiments, the anterior portion extends from the lateral portion and terminates at the anterior opening. In some embodiments, the posterior portion extends from the lateral portion and terminates at the posterior opening. In some embodiments, the transition point comprises an outermost perimeter of the annular body. In some embodiments, the outermost diameter of the annular body spans the outermost perimeter of the annular body. In some embodiments, the lateral portion extends from the anterior portion to the posterior portion through a plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening. In some embodiments, the lateral portion comprises a plurality of lateral openings. In some embodiments, the lateral portion protrudes radially beyond the anterior portion and the posterior portion. In some embodiments, the lateral portion comprises an outermost diameter of the annular body.

[0094] In some embodiments of the IOL device disclosed herein, the outermost diameter of the annular body is in the range of between about 5.0-20 mm. For example, in some embodiments, the outermost diameter is in the range of between about 5-6 mm, about 5-7 mm, about 5-8 mm, about 5-9 mm, about 6-7 mm, about 6-8 mm, about 6-9 mm, about 6-10 mm, about 7-8 mm, about 7-9 mm, about 7-10 mm, about 8-9 mm, about 8-10 mm, or about 9-10 mm, about 5-10 mm, about 5-12 mm, about 6-12 mm, about 8-12 mm, about 10-12 mm, about 10-15 mm, about 12-14 mm, about 12-15 mm, about 14-15 mm, about 5-18 mm, about 8-20 mm, about 10-20 mm, about 10-18 mm, about 12-20 mm, about 12-18 mm, or about 14- 20 mm, such as about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, about 16 mm, about 17 mm, about 18 mm, about 19 mm, or about 20 mm. In some embodiments, the annular body comprises a curve between the anterior and posterior portions, wherein the curve comprises a radius in the range of between about 0.1-10 mm. In some embodiments, the arcuate path of the surface along the anterior portion from the anterior opening comprises a radius in the range of between about 5.0-20 mm. In some embodiments, the arcuate path ofthe surface along the posterior portion from the posterior opening comprises a radius in the range of between about 1.0-20 mm. In some embodiments, the annular body comprises a vertical portion between the anterior and posterior portions, wherein the vertical portion is substantially parallel to the optical axis.

[0095] In some embodiments of the IOL device disclosed herein, the annular body further comprises a plurality of lateral openings. In some embodiments, the plurality of lateral openings comprises 2-4, 2-6, or 2-8 lateral openings. In some embodiments, the plurality of lateral openings comprises 2, 3, 4, 5, 6, 7, or 8 lateral openings. For example, in some embodiments, the plurality of lateral openings comprises at least a first lateral opening substantially opposite at least a second lateral opening. In some embodiments, the plurality of lateral openings comprises at least a third lateral opening substantially opposite at least a fourth lateral opening. In some embodiments, the plurality of lateral openings are positioned along a plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening. In some embodiments, the plurality of lateral openings is substantially symmetrical along the plane at the midpoint. In some embodiments, the plurality of lateral openings are substantially evenly spaced about a circumference of the annular body; optionally wherein the plurality of lateral openings are substantially evenly spaced about a circumference at the outermost diameter of the annular body. In some embodiments, the plurality of lateral openings are positioned along the lateral portion of the annular body. In some embodiments, the plurality of lateral openings are substantially symmetrical along the lateral portion of the annular body. In some embodiments, the plurality of lateral openings are substantially evenly spaced about a circumference of the lateral portion of the annular body; optionally wherein the plurality of lateral openings are substantially evenly spaced about a circumference at the outermost diameter of the lateral portion of the annular body. In some embodiments, the plurality of lateral openings are positioned perpendicularly, substantially perpendicularly, and / or obliquely to the optical axis. In some embodiments, at least one lateral opening of the plurality of lateral openings has a height sufficient to accommodate a haptic of an IOL; optionally wherein each of the plurality of lateral openings has a height sufficient to accommodate a haptic of an IOL. For example, in some embodiments, at least one lateral opening of the plurality of lateral openings has a height that is in the range of between about 15-75%, about 20-70%, about 25-60%, or about 25-50% of the height of the annular body; wherein each of the plurality of lateral openings has a height that is in the range of between 15-75%, 20-70%, 25-60%, or 25-50% of the height of the annular body. In some embodiments, at least one lateral opening of the pluralityof lateral openings has a height in the range of between about 500 microns to about 2 mm, about 600 microns to about 2 mm, about 750 microns to about 1.5 mm, or about 0.5 mm to about 1.0 mm; optionally wherein each of the plurality of lateral openings has a height in the range of between about 500 microns to about 2 mm, about 600 microns to about 2 mm, about 750 microns to about 1.5 mm, or about 0.5 mm and about 1.0 mm. In some embodiments, the at least one lateral opening has a rectangular profile; optionally wherein each of the plurality of lateral openings has a rectangular profile. In some embodiments, the at least one lateral opening has an elliptical profile; optionally wherein each of the plurality of lateral openings has an elliptical profile. In some embodiments, the at least one lateral opening has a trapezoidal profile; optionally wherein each of the plurality of lateral openings has a trapezoidal profile. In some embodiments, at least one lateral opening of the plurality of lateral openings has a tapered profile such that a posterior portion of the at least one lateral opening has a width that is less than an anterior portion of the at least one lateral opening; optionally wherein each of the plurality of lateral openings has a tapered profile such that each lateral opening of the plurality of lateral openings has a posterior portion has a width that is less than an anterior portion of said respective lateral opening.

[0096] In some embodiments of the IOL device disclosed herein, the annular body has a thickness sufficient to provide adequate stiffness to maintain its shape upon insertion in the capsular bag. In some embodiments, the annular body has a thickness in the range of between about 0.01-1.0 mm. For example, in some embodiments, the annular body has a thickness in the range of between about 0.01-0.05 mm, about 0.01-0.1 mm, about 0.01-0.5 mm, about 0.01-1.0 mm, about 0.05-0.1 mm, about 0.05-0.5 mm, about 0.05-1.0 mm, about 0.1-0.5 mm, about 0.1-1.0 mm, or about 0.5-1.0 mm, such as a thickness of about 0.01 mm, about 0.02 mm, about 0.03 mm, about 0.04 mm, about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, or about 1.0 mm. In some embodiments, the annular body has an interior surface and an outer surface. In some embodiments, the interior surface of the annular body comprises a ridge. In some embodiments, the annular body forms an interior ridge on the interior surface between the anterior and posterior openings. In some embodiments, the ridge is configured for securing and / or retaining an intraocular lens. In some embodiments, the ridge is configured for securing and / or retaining an intraocular lens. In some embodiments, a portion of the annular body is substantially parallel to the optical axis. In some embodiments, a portion of the annular body is substantially perpendicular to the plane of the anterior and posterioropenings.

[0097] In some embodiments of the IOL device disclosed herein, the annular body comprises an internal cavity. In some embodiments, the internal cavity of the annular body extends between the anterior portion and the posterior portion. In some embodiments, the internal cavity of the annular body has a volume in the range of about 15-85 mm3. For example, in some embodiments, the internal cavity of the annular body has a volume in the range of about 15-20 mm3, about 15-25 mm3, about 20-25 mm3, about 20-30 mm3, about 25-30 mm3, about 25-35 mm3, about 30-35 mm3, about 30-40 mm3, about 35-40 mm3, about 35-45 mm3, about 40-45 mm3, about 40-50 mm3, about 45-50 mm3, about 45-55 mm3, about SO-55 mm3, about 50-60 mm3, about 55-60 mm3, about 55-65 mm3, about 60-65 mm3, about 60-70 mm3, about 65-70 mm3, about 65-75 mm3, about 70-75 mm3, about 70-80 mm3, about 75-80 mm3, about 75-85 mm3, or about 80-85 mm3. In some embodiments, the internal cavity of the annular body has a volume of about 15 mm3, about 20 mm3, about 25 mm3, about 30 mm3, about 35 mm3, about 40 mm3, about 45 mm3, about 50 mm3, about 55 mm3, about 60 mm3, about 65 mm3, about 70 mm3, about 75 mm3, about 80 mm3, or about 85 mm3. In some embodiments, the anterior portion comprises a first volume and the posterior portion comprises a second volume. In some embodiments, the anterior portion and the posterior portion have substantially equal volumes. In some embodiments, the anterior portion has a greater volume than the posterior portion. In some embodiments, the posterior portion has a greater volume than the anterior portion.

[0098] In some embodiments of the IOL device disclosed herein, the annular body has a size that is substantially smaller than the size of a capsular bag. In some embodiments, the annular body has a size that is 10-50% smaller than the size of a capsular bag. In some embodiments, the size of the annular body minimizes anterior, posterior, and / or radial protrusion of the annular body into the capsular bag. In some embodiments, the annular body has a volume that is substantially smaller than the volume of a capsular bag. In some embodiments, the annular body has a volume that is 10-50% smaller than the volume of a capsular bag. In some embodiments, the volume of the annular body minimizes anterior, posterior, and / or radial protrusion of the annular body into the capsular bag. In some embodiments, the shape of the annular body minimizes anterior, posterior, and / or radial protrusion of the annular body into the capsular bag. In some embodiments, the curvature of the annular body is such that the tangent angle of a protruding haptic varies longitudinally along the annular body.

[0099] In some embodiments, provided herein is an intraocular lens device, comprising:i) an intraocular ring that is radially centered along an optical axis; ii) a plurality of haptics extending from the intraocular ring; and iii) a plurality of loops extending from the intraocular ring and substantially perpendicular to the optical axis.

[0100] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, the each of the plurality of loops extend anteriorly from the intraocular ring relative to a plane of the intraocular ring. In some embodiments, each of the plurality of loops extend posteriorly from the intraocular ring relative to a plane of the intraocular ring.

[0101] In some embodiments, the intraocular ring comprises a substantially toroidal body portion. In some embodiments, the toroidal body portion has a substantially square cross- sectional shape, a substantially rectangular cross-sectional shape, a substantially circular cross-sectional shape, a substantially oval cross-sectional shape, a substantially trapezoidal cross-sectional shape, or a substantially hexagonal cross-sectional shape. In some embodiments, the intraocular ring comprises an annular body portion having a substantially cylindrical shape; optionally wherein the intraocular ring comprises an annular body portion having a cylindrical shape.

[0102] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, the plurality of loops comprises 2-4, 2-6, or 2-8 loops, such as 2, 3, 4, 5, 6, 7, or 8 loops. In some embodiments, the plurality of loops comprises at least a first loop substantially opposite at least a second loop. In some embodiments, the plurality of loops comprises at least a third loop substantially opposite at least a fourth loop. In some embodiments, the plurality of loops are substantially evenly spaced about a circumference of the intraocular ring. In some embodiments, the plurality of loops are positioned perpendicularly, substantially perpendicularly, and / or obliquely to the optical axis.

[0103] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, at least one loop or each of the plurality of loops has a height sufficient to accommodate a haptic of an IOL. In some embodiments, at least one loop or each loop of the plurality of loops has a diameter in the range of between about 500 microns to about 4 mm, about 600 microns to about 3.5 mm, about 750 microns to about 1.5 mm, about 1.0 mm to about 2.0 mm, about 1.0 mm to about 3.0 mm, about 1.0 mm to about 3.5 mm, about 1.5 mm to about 2.5 mm, about 1.5 mm to about 2.5 mm, about 2.0 to about 3.0 mm, about 2.0 mm to about 3.5 mm, about 2.5 mm to about 3.0 mm, about 2.5 to about 3.5 mm, or about 0.5 mm to about 1.0 mm; optionally wherein at least one loop or each of the plurality of loops has a diameter of about 500 microns, about 1.0 mm, about 1.5 mm, about 1.75 mm, about 2.0 mm, about 2.25 mm, about 2.5 mm, about 2.75 mm, about 3.0 mm, about 3.25 mm, or about 3.5mm.

[0104] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, at least one loop or each of the plurality of loops has a substantially toroidal shape, a substantially tubular shape, a substantially square shape, a substantially rectangular shape, a substantially elliptical shape, a substantially circular shape, a substantially oval shape, a substantially trapezoidal shape, or a substantially hexagonal shape, or combinations thereof. In some embodiments, the at least one loop or each of the plurality of loops has a substantially square cross-sectional shape, a substantially rectangular cross-sectional shape, a substantially circular cross-sectional shape, a substantially oval cross-sectional shape, a substantially trapezoidal cross-sectional shape, or a substantially hexagonal cross-sectional shape. In some embodiments, the at least one loop or each of the plurality of loops has a substantially toroidal shape, and has a substantially square, rectangular, circular, oval, trapezoidal, or hexagonal cross-sectional shape. In some embodiments, the at least one loop or each of the plurality of loops has a substantially elliptical, circular, or oval shape, and has a substantially square, rectangular, circular, oval, trapezoidal, or hexagonal cross-sectional shape. In some embodiments, the at least one loop or each of the plurality of loops has a substantially square, rectangular, or trapezoidal shape, and has a substantially square, rectangular, circular, oval, trapezoidal, or hexagonal cross-sectional shape. In some embodiments, at least one loop of the plurality of loops has a tapered profile such that a posterior portion of the at least one loop has a width that is less than an anterior portion of the at least one loop; optionally wherein each of the plurality of loops has a tapered profile such that each loop of the plurality of loops has a posterior portion has a width that is less than an anterior portion of said respective loop. In some embodiments, each loop of the plurality of loops both extends from a unique portion and returns to that same unique portion. In some embodiments, each loop of the plurality of loops is attached from a unique portion along the intraocular ring. In some embodiments, each loop of the plurality of loops has two attachment points with the intraocular ring; optionally sharing both attachment points with both adjacent neighboring loops. In some embodiments, an arch, truss, lattice, mesh, and / or rod extends between two or more loops of the plurality of loops for increased stability.

[0105] In some embodiments, provided herein is an intraocular lens device, comprising: i) an intraocular ring that is radially centered along an optical axis; ii) a plurality of haptics extending from the intraocular ring; and iii) a plurality of nodes arranged around the intraocular ring; wherein the intraocular ring comprises a continuous recess, a plurality of perforations, or a plurality of slits, or combinations thereof, along a circumference of theintraocular ring.

[0106] In some embodiments, the intraocular ring comprises an annular body portion comprising: i) an anterior surface; ii) a posterior surface: and iii) a sidewall extending substantially parallel to the optical axis between the anterior surface and the posterior surface, wherein the sidewall has an interior surface and an exterior surface proximal and distal from said optical axis, respectively. In some embodiments, the annular body portion of the intraocular ring has a substantially toroidal shape. In some embodiments, the substantially toroidal shaped annular body portion has a substantially square cross-sectional shape or a substantially rectangular cross-sectional shape.

[0107] In some embodiments, the intraocular ring comprises the continuous recess along the circumference of the intraocular ring. In some embodiments, the continuous recess is along the sidewall. In some embodiments, the continuous recess is along a median portion of the exterior surface of the sidewall. In some embodiments, the continuous recess along the sidewall comprises a cutout of a portion of the exterior surface of the sidewall. In some embodiments, the cutout portion extends about 15% to no more than about 80% into the sidewall towards the interior surface of said sidewall; optionally extends about 25-80%, about 35-80%, about 45-80%, about 55-80%, about 65-80%, about 20-70%, about 30-70%, about 40-70%, about 50-70%, about 60-70%, about 30-60%, about 40-60%, about 50-60%, or about 40-50% into the sidewall towards the interior surface of said sidewall. In some embodiments, the cutout portion extends between the anterior surface and the posterior surface of about 15% to no more than about 50% along the median portion of the exterior surface of said sidewall; optionally extends between the anterior surface and the posterior surface of about 15-50%, about 15-45%, about 15-40%, about 15-35%, about 15-30%, about 15-25%, about 20-45%, about 25-35%, about 25-50%, or about 30-45% along the median portion of the exterior surface of said sidewall.

[0108] In some embodiments, the intraocular ring comprises the plurality of perforations along the circumference of the intraocular ring. In some embodiments, the plurality of perforations is along a median portion of the exterior surface of the sidewall. In some embodiments, a plurality or each of the plurality of perforations extend through the sidewall. In some embodiments, a plurality or each of the plurality of perforations extend between the anterior surface and the posterior surface of about 15% to no more than about 50% along the median portion of the exterior surface of said sidewall; optionally extend between the anterior surface and the posterior surface of about 15-50%, about 15-45%, about 15-40%, about 15- 35%, about 15-30%, about 15-25%, about 20-45%, about 25-35%, about 25-50%, or about30-45% along the median portion of the exterior surface of said sidewall.

[0109] In some embodiments, the intraocular ring comprises the plurality of slits along the circumference of the intraocular ring. In some embodiments, the plurality of slits is along a median portion of the exterior surface of the sidewall. In some embodiments, a plurality or each of the plurality of slits extend through the sidewall. In some embodiments, a plurality or each of the plurality of slits extend between the anterior surface and the posterior surface of about 15% to no more than about 50% along the median portion of the exterior surface of said sidewall; optionally extend between the anterior surface and the posterior surface of about 15-50%, about 15-45%, about 15-40%, about 15-35%, about 15-30%, about 15-25%, about 20-45%, about 25-35%, about 25-50%, or about 30-45% along the median portion of the exterior surface of said sidewall. In some embodiments, a plurality or each of the plurality of slits extend about 15 degrees to no more than about 45 degrees radially about the optical axis and along the median portion of the exterior surface of said sidewall. In some embodiments, the plurality of slits comprises 2, 3, or 4 slits along a median portion of the exterior surface of the sidewall.

[0110] In some embodiments, the intraocular ring comprises a combination of the continuous recess, the plurality of perforations, and the plurality of slits along the circumference of the intraocular ring. In some embodiments, the intraocular ring comprises the continuous recess and the plurality of perforations along the circumference of the intraocular ring. In some embodiments, the intraocular ring comprises the continuous recess and the plurality of slits along the circumference of the intraocular ring. In some embodiments, the intraocular ring comprises the plurality of perforations and the plurality of slits along the circumference of the intraocular ring. In some embodiments, the intraocular ring comprises the continuous recess, the plurality of perforations, and the plurality of slits along the circumference of the intraocular ring.

[0111] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, the continuous recess, the plurality of perforations, and / or the plurality of slits are suitable for dividing a portion of the sidewall along the median portion of the intraocular ring; optionally wherein the continuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring creates at least one line of weakness dividing at least one portion of the intraocular ring. In some embodiments, the intraocular ring comprises one or more divided portions of the sidewall along the median portion of said intraocular ring. In some embodiments, a divided portion of the one or more divided portions of the sidewall along the median portion of saidintraocular ring are suitable for insertion of a haptic of an intraocular lens (IOL). In some embodiments, each divided portion of the one or more divided portions of the sidewall along the median portion of said intraocular ring are suitable for insertion of a haptic of an intraocular lens (IOL). In some embodiments, the intraocular ring is sufficiently large to permit the insertion of an IOL; optionally wherein the intraocular ring has an internal diameter that is about 0.1 mm to about 1.0 mm greater than an optic diameter of an IOL, such as about 0.1 mm, about 0.2 mm, about 0.25 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.75 mm, about 0.8 mm, about 0.9 mm, or about 1.0 mm, greater than an optic diameter of an IOL. In some embodiments, the intraocular ring is sufficiently large to permit the insertion of an IOL with an optical diameter in the range of between about 4.0-8.0 mm; optionally about 6.0 mm. In some embodiments, the intraocular ring has an internal diameter of 6.25 mm to 8.0 mm; optionally an internal diameter of 7.5 mm. In some embodiments, the intraocular ring has an outermost diameter in the range of between about 5-10 mm, for example, in the range of between about 5-6 mm, about 5-7 mm, about 5-8 mm, about 5-9 mm, about 5.0-10 mm, about 6-7 mm, about 6-8 mm, about 6-9 mm, about 6-10 mm, about 7-8 mm, about 7-9 mm, about 7-10 mm, about 8-9 mm, about 8- 10 mm, about 9-10 mm, about 5-10 mm, about 6-6.5 mm, about 6-7 mm, about 6-7.5 mm, about 6-8 mm, about 6.25-7 mm, about 6.25-7.25 mm, about 6.5-7 mm, about 6.5-7.25 mm, about 6.5-7.5 mm, about 6.75-7.25 mm, about 7-7.5 mm, about 7-8 mm, about 7.25-8 mm, about 7.25-7.75 mm, or about 7.5-8 mm, such as about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 5.25 mm, about 5.5 mm, about 5.75 mm, about 6.25 mm, about 6.5 mm, about 6.75 mm, about 7.25 mm, about 7.5 mm, about 7.75, about 8.25 mm, about 8.5 mm, about 8.75 mm, about 9.25 mm, or about 9.5 mm.

[0112] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, the plurality of nodes is arranged in a symmetrical pattern around the intraocular ring. In some embodiments, each of the plurality of nodes is arranged about 15- 45 degrees from adjacent nodes along the intraocular ring; optionally wherein the plurality of nodes is arranged about 15-30, 20-40, 25-45, or 30-45 degrees around the intraocular ring, such as about 15, 20, 25, 30, 35, 40, or 45 degrees around the intraocular ring. In some embodiments, the plurality of nodes is arranged about 15-45 degrees around the intraocular ring; optionally wherein the plurality of nodes is arranged about 15-30, 20-40, 25-45, or 30- 45 degrees around the intraocular ring, such as about 15, 20, 25, 30, 35, 40, or 45 degrees around the intraocular ring. In some embodiments, the plurality of nodes is arranged along the anterior surface of the intraocular ring. In some embodiments, the plurality of nodes isarranged along the posterior surface of the intraocular ring. In some embodiments, the plurality of nodes is arranged along the anterior and posterior surfaces of the intraocular ring.

[0113] In some embodiments, the intraocular ring has radial symmetry. In some embodiments, the intraocular ring has a substantially toroidal shape. In some embodiments, the intraocular ring is bilaterally symmetrical across a plane perpendicular to the optical axis. In some embodiments, the intraocular ring is bilaterally symmetrical across a plane dividing anterior and posterior portions of the intraocular ring. In some embodiments, the intraocular ring is bilaterally symmetrical across a plane parallel to anterior and posterior portions of the intraocular ring.

[0114] In some embodiments, the height of the intraocular ring along the optical axis is in the range of between about 0.5-3.5 mm, for example, between about 0.5-1.0 mm, about 0.5- 1.5 mm, about 0.5-2.0 mm, about 0.5-2.5 mm, about 0.5-3.0 mm, about 0.5-3.5 mm, about 1.0-1.5 mm, about 1.0-2.0 mm, about 1.0-2.5 mm, about 1.0-3.0 mm, about 1.0-3.5 mm, about 1.5-2.0 mm, about 1.5-2.5 mm, about 2.0-2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, or about 3.0-3.5 mm, such as about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, or about 3.5 mm.

[0115] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, the continuous recess, the plurality of perforations, and / or the plurality of slits along the circumference of the intraocular ring have a height along the optical axis is in the range of between about 0.1-0.5 mm, about 0.1-0.2 mm, about 0.15-0.4 mm, about 0.15- 0.3 mm, about 0.15-0.25 mm, about 0.2-0.5 mm, or about 0.2-0.3 mm, such as about 0.1 mm, about 0.15 mm, about 0.2 mm, about 0.25 mm, about 0.3 mm, about 0.4 mm, or about 0.5 mm.

[0116] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, the plurality of loops protrudes tangentially beyond a diameter of the intraocular ring. In some embodiments, the intraocular ring has a thickness sufficient to provide adequate stiffness to maintain its shape upon insertion in the capsular bag. In some embodiments, the intraocular ring and / or a loop of the plurality of loops has a thickness in the range of between about 0.01-1.5 mm, for example, between about 0.01-0.05 mm, about 0.01- 0.1 mm, about 0.01-0.5 mm, about 0.01-1.0 mm, about 0.01-1.5 mm, about 0.05-0.1 mm,about 0.05-0.5 mm, about 0.05-1.0 mm, about 0.05-1.5 mm, about 0.1-0.5 mm, about 0.1-1.0 mm, about 0.1-1.5 mm, about 0.5-1.0 mm, about 0.5-1.5 mm, or about 1.0-1.5 mm, such as about 0.01 mm, about 0.02 mm, about 0.03 mm, about 0.04 mm, about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, or about 1.5 mm.

[0117] In some embodiments, the intraocular ring has an interior surface and an outer surface. In some embodiments, the interior surface of the intraocular ring comprises a ridge. In some embodiments, the ridge is configured for securing and / or retaining an intraocular lens. In some embodiments, the intraocular ring comprises an internal cavity. In some embodiments, the internal cavity of the intraocular ring has a volume in the range of about 0.5-100 mm3. In some embodiments, the intraocular ring has a size that is substantially smaller than the size of a capsular bag. In some embodiments, the intraocular ring has a size that is 10-50% smaller than the size of a capsular bag. In some embodiments, the size of the intraocular ring minimizes anterior, posterior, and / or radial protrusion of the intraocular ring into the capsular bag. In some embodiments, the shape of the intraocular ring minimizes anterior, posterior, and / or radial protrusion of the intraocular ring into the capsular bag.

[0118] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, the device has a weight in the range of between about 2-250 mg, for example, between about 2-10 mg, about 2-15 mg, about 2-25 mg, about 2-35 mg, about 2-45 mg, about 2-55 mg, about 2-65 mg, about 2-70 mg about 10-15 mg, about 10-20 mg, about 10-30 mg, about 10-40 mg, about 10-50 mg, about 10-60 mg, about 10-70 mg, about 15-25 mg, about 15-35 mg, about 15-45 mg, about 15-55 mg, about 15-65 mg, about 20-25 mg, about 25-30 mg, about 25-35 mg, about 30-35 mg, about 35-40 mg, about 35-45 mg, about 40-45 mg, about 45-50 mg, about 45-55 mg, about 50-55 mg, about 55-60 mg, about 55-65 mg, about 60-65 mg, about 60-70 mg, about 65-70 mg, about 2-100 mg, about 2-125 mg, about 2-150 mg, about 2-175 mg, about 2-200 mg, about 2-225 mg, about 2-250 mg, about 50-100 mg, about 50-125 mg, about 50-150 mg, about 50-175 mg, about 50-200 mg, about 50-225 mg, about 50-250 mg, about 100-125 mg, about 100-150 mg, about 100-175 mg, about 100-200 mg, about 100-225 mg, about 100-250 mg, about 150-175 mg, about 150-200 mg, about 150-225 mg, or about 150-250 mg. In some embodiments, the device has a weight of about 5.0 mg, about 10 mg, about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg, about 40 mg, about 45 mg, about 50 mg, about 55 mg, about 60 mg, about 65 mg,about 70 mg, about 100 mg, about 125 mg, about 150 mg, about 175 mg, about 200 mg, about 225 mg, or about 250 mg. In some embodiments, the plurality of haptics are configured to support the weight of the device. In some embodiments, each of the plurality of haptics extends smoothly from the intraocular ring. In some embodiments, at least one haptic or each of the plurality of haptics has a smooth surface along the entire length of the haptic. In some embodiments, the plurality of haptics are configured to be non-abrasive and / or non-irritating to the sulcus of an eye. In some embodiments, the plurality of haptics are configured to be non-abrasive and / or non-irritating to the cornea of an eye.

[0119] In some embodiments of the IOL device comprising the intraocular ring as disclosed herein, the device is flexible; optionally wherein the device is flexible enough to be loaded into a cartridge for implantation. In some embodiments, the device is collapsible, compressible and / or foldable; optionally wherein the device is collapsible, compressible and / or foldable enough to be loaded into a cartridge for implantation. In some embodiments, the device is collapsible, compressible and / or foldable; optionally wherein the device is collapsible, compressible and / or foldable enough to be insertable using a pair of forceps or other grasping instrument, and / or injectable by a needle and / or a cartridge; optionally injectable by a cartridge with a width of about 2.4 mm. In some embodiments, the device is deformable for insertion into a capsular bag of an eye; optionally wherein the device is deformable enough to be loaded into a cartridge for implantation. In some embodiments, the device is self-expandable upon insertion into a capsular bag of an eye. In some embodiments, the device is a prosthetic capsular device. In some embodiments, the collapsed, compressed and / or folded device has a length of about 8-15 mm; optionally a length of around 13 mm in length.

[0120] In some embodiments, the intraocular ring is hydrophobic. In some embodiments, the intraocular ring is hydrophilic. In some embodiments, the device comprises a biocompatible, compressible, flexible, elastic, hydrophobic, and / or hydrophilic material; optionally wherein the device comprises poly(methyl-methacrylate) (PMMA), hydrophilic acrylic or hydrophobic acrylic, hydrophilic silicone or hydrophobic silicone, polycarbonate, polypropylene, polystyrene, polyethylene, noryl, polysulfone, acetal, acrylonitrile butadiene styrene, PC-ABS alloy, nylon, nylon 6, nylon 6,6, nylon 11, nylon 12, thermoplastic elastomer, thermoplastic polyurethane, thermoplastic vulcanizate, coloring agents, talc, stiffening agents, glass fibre, and / or antimicrobial agents. In some embodiments, the intraocular ring has a smooth, continuous surface. In some embodiments, the intraocular ring has a non-porous surface.

[0121] In some embodiments of the IOL device disclosed herein, the plurality of haptics are arranged around the anterior portion; optionally wherein the plurality of haptics are arranged in a symmetrical pattern around the anterior portion. In some embodiments, each of the plurality of haptics originates from positions proximal to the anterior opening; optionally wherein each of the plurality of haptics originates from positions radially symmetrical and proximal to the anterior opening. In some embodiments, each of the plurality of haptics originate proximate to the anterior opening. In some embodiments, the plurality of haptics radially extend from the anterior portion of the annular body. In some embodiments, the plurality of haptics extend beyond the outermost perimeter of the annular body. In some embodiments, the plurality of haptics extend laterally beyond the outermost diameter of the annular body.

[0122] In some embodiments of the IOL device disclosed herein, at least one haptic of the plurality of haptics extends at an angle in the range of between 30 degrees below and 30 degrees above a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body. For example, in some embodiments, each haptic of the plurality of haptics extends at an angle in the range of between 30 degrees below and 30 degrees above a plane where the respective haptic of the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, each haptic of the plurality of haptics extends at an angle in the range of between 20 degrees below and 20 degrees above a plane where said respective haptic of the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, the plurality of haptics extend at an angle in the range of between 30 degrees below and 30 degrees above a plane where the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, each of the plurality of haptics originates on substantially a single plane.

[0123] In some embodiments of the IOL device disclosed herein, the plurality of haptics extends in a posterior direction; optionally wherein the plurality of haptics extends in a posterior direction towards the plane bifurcating the anterior portion and the posterior portion. In some embodiments, the degree of posteriorly-directed angulation of the plurality of haptics is between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below a plane where at least one haptic of the plurality of haptics originates from the anterior portion. For example, in some embodiments, the degree of posteriorly-directed angulation of the plurality of haptics is about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 degrees below a plane where at least one haptic of the plurality of haptics originates from the anterior portion. In some embodiments,the degree of posteriorly-directed angulation of the plurality of haptics is 10 degrees below a plane where at least one haptic of the plurality of haptics originates from the anterior portion. In some embodiments, at least one haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, each haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below a plane where the respective haptic of the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, the plurality of haptics extend at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below a plane where the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, each of the plurality of haptics originates on substantially a single plane.

[0124] In some embodiments of the IOL device disclosed herein, the plurality of haptics extends in an anterior direction; optionally wherein the plurality of haptics extends in an anterior direction away from the plane bifurcating the anterior portion and the posterior portion. In some embodiments, the plurality of haptics extends in an anterior direction and above the plane of the anterior opening. In some embodiments, the degree of anteriorly- directed angulation of the plurality of haptics is between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees above a plane where at least one haptic of the plurality of haptics originates from the anterior portion. For example, in some embodiments, the degree of anteriorly-directed angulation of the plurality of haptics is about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 degrees above a plane where at least one haptic of the plurality of haptics originates from the anterior portion. In some embodiments, the degree of anteriorly-directed angulation of the plurality of haptics is 10 degrees above a plane where at least one haptic of the plurality of haptics originates from on the anterior portion. In some embodiments, at least one haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees above a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, each haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees above a plane where the respective haptic of theplurality of haptics originates from the anterior portion of the annular body. In some embodiments, the plurality of haptics extend at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees above a plane where the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, each of the plurality of haptics originates on substantially a single plane.

[0125] In some embodiments of the IOL device disclosed herein, the plurality of haptics extends in a direction substantially parallel to the plane bifurcating the anterior portion and the posterior portion. In some embodiments, the plurality of haptics extends in a direction substantially parallel to a plane perpendicular to the optical axis. In some embodiments, the plurality of haptics extends in a direction substantially parallel to a plane where at least one haptic of the plurality of haptics originates from the anterior portion. In some embodiments, the plurality of haptics extends beyond the an outermost perimeter of the annular body at an angle such that the plurality is substantially coplanar with the anterior opening. In some embodiments, at least one haptic of the plurality of haptics extends at an angle substantially parallel to a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, each haptic of the plurality of haptics extends at an angle substantially parallel to a plane where the respective haptic of the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, the plurality of haptics extend at an angle substantially parallel to a plane where the plurality of haptics originates from the anterior portion of the annular body. In some embodiments, each of the plurality of haptics originates on substantially a single plane.

[0126] In some embodiments of the IOL device disclosed herein, the plurality of haptics are configured to be substantially rotationally symmetric with respect to the optical axis. In some embodiments, the plurality of haptics are configured to be substantially radially symmetric with respect to the optical axis. In some embodiments, the plurality of haptics comprises 2-6 haptics, for example, the plurality of haptics comprises 2, 3, 4, 5, or 6 haptics. In some embodiments, the plurality of haptics comprises of two diametrically opposed haptics. In some embodiments, the plurality of haptics comprises of three trigonally positioned haptics. In some embodiments, the plurality of haptics comprises of four equally spaced haptics. In some embodiments, the plurality of haptics are flexible. In some embodiments, the plurality of haptics are collapsible. In some embodiments, the plurality of haptics are deformable; optionally wherein the plurality of haptics are deformable for insertion into a capsular bag of an eye. In some embodiments, the plurality of haptics areself-expandable; optionally wherein the plurality of haptics are self-expandable upon insertion into a capsular bag of an eye. In some embodiments, at least one haptic or each of the plurality of haptics has a wire shape. In some embodiments, at least one haptic or each of the plurality of haptics has a boomerang wire shape. In some embodiments, at least one haptic or each of the plurality of haptics has an arcing wire shape. In some embodiments, at least one haptic or each of the plurality of haptics has a thin, cylindrical wire shape. In some embodiments, at least one haptic or each of the plurality of haptics has a petal-like shape. In some embodiments, at least one haptic or each of the plurality of haptics comprises a first substantially linear portion, an arcuate portion, and a second substantially linear portion. In some embodiments, at least one haptic or each of the plurality of haptics has a point of peak convexity. In some embodiments, at least one haptic or each of the plurality of haptics comprises a parabolic arc. In some embodiments, at least one haptic or each of the plurality of haptics extend radially from the anterior portion and then curve back towards the anterior portion.

[0127] In some embodiments of the IOL device disclosed herein, each of the plurality of haptics has a cross-sectional diameter between about 0.001-1.5 mm. For example, in some embodiments, each of the plurality of haptics has a cross-sectional diameter between about 0.001-0.01 mm, about 0.001-0.1 mm, about 0.01-1.0 mm, about 0.1 -1.0 mm, about 0.1-0.5 mm, about 0.5-1.5 mm, about 0.5-1.0 mm, or about 1.0-1.5 mm, such as a cross-sectional diameter of about 0.01 mm, about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.1 mm, about 0.11 mm, about 0.12 mm, about 0.13 mm, about 0.14 mm, about 0.15 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, or about 1.5 mm.

[0128] In some embodiments of the IOL device disclosed herein, at least one haptic or each of the plurality of haptics has a pathlength in the range of between about 10-16 mm. For example, in some embodiments, at least one haptic or each of the plurality of haptics has a pathlength in the range of between about 10-12 mm, about 10-12 mm, about 10-13 mm, about 12-13 mm, about 12-14 mm, about 13-14 mm, about 13-15 mm, about 14-15 mm, about 14-16 mm, or about 15-16 mm, such as a pathlength of about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0129] In some embodiments of the IOL device disclosed herein, a wingspan between two diametrically opposed haptics of the plurality of haptics comprises the distance between the points of peak convexity of each haptic. In some embodiments, a configurationcomprising two haptics has a wingspan that is in the range of between about 5.0-16 mm. For example, in some embodiments, a configuration comprising two haptics has a wingspan that is in the range of between about 5-8 mm, about 5-11 mm, about 5-14 mm, about 5-16, about 6-9 mm, about 6-12 mm, about 6-15 mm, about 6-16 mm, about 7-10 mm, about 7-13 mm, about 7-16 mm, about 8-11 mm, about 8-14 mm, about 8-16 mm, about 9-12 mm, about 9-14 mm, about 9-16 mm, about 10-12 mm, about 10-14 mm, about 10-16 mm, about 11-13 mm, about 11-16 mm, about 12-14 mm, about 12-16 mm, about 13-15 mm, about 13-16 mm, about 14-15 mm, about 14-16 mm, or about 15-16 mm. In some embodiments, a configuration comprising two haptics has a wingspan that is about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0130] In some embodiments of the I0L device disclosed herein, a single haptic has a curve at the point of peak convexity comprising a radius in the range of between about 3-15 mm. For example, in some embodiments, a single haptic has a curve at the point of peak convexity comprising a radius in the range of between about 3-4 mm, about 3-5 mm, about 4- 5 mm, about 4-6 mm, about 5-6 mm, about 5-7 mm, about 6-7 mm, about 6-8 mm, about 7-8 mm, about 7-9 mm, about 8-9 mm, about 8-10 mm, about 9-10 mm, about 9-11 mm, about 10-11 mm, about 10-12 mm, about 11-12 mm, about 11-13 mm, about 12-13 mm, about 12- 14 mm, about 13-14 mm, about 13-15 mm, or about 14-15 mm, such as a radius of about 3.0 mm, about 4.0 mm, about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0131] In some embodiments of the IOL device disclosed herein, the plurality of haptics are suitable for pressing against the tissue of the sulcus of the eye upon implantation. In some embodiments, the plurality of haptics are suitable for supporting the device within a capsular bag upon implantation in an eye. In some embodiments, device has a weight in the range of between about 5-250 mg. For example, in some embodiments, the device has a weight in the range of between about 5-10 mg, about 5-15 mg, about 5-25 mg, about 5-35 mg, about 5-45 mg, about 5-55 mg, about 5-65 mg, about 5-70 mg, about 10-15 mg, about 10-20 mg, about 10-30 mg, about 10-40 mg, about 10-50 mg, about 10-60 mg, about 10-70 mg, about 15-25 mg, about 15-35 mg, about 15-45 mg, about 15-55 mg, about 15-65 mg, about 20-25 mg, about 25-30 mg, about 25-35 mg, about 30-35 mg, about 35-40 mg, about 35-45 mg, about 40-45 mg, about 45-50 mg, about 45-55 mg, about 50-55 mg, about 55-60 mg, about 55-65 mg, about 60-65 mg, about 60-70 mg, about 65-70 mg, about 5-100 mg,about 5-125 mg, about 5-150 mg, about 5-175 mg, about 5-200 mg, about 5-225 mg, about 5- 250 mg, about 50-100 mg, about 50-125 mg, about 50-150 mg, about 50-175 mg, about 50- 200 mg, about 50-225 mg, about 50-250 mg, about 100-125 mg, about 100-150 mg, about 100-175 mg, about 100-200 mg, about 100-225 mg, about 100-250 mg, about 150-175 mg, about 150-200 mg, about 150-225 mg, or about 150-250 mg, for example, preferably 5-70 mg, or such as a weight of about 5.0 mg, about 10 mg, about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg, about 40 mg, about 45 mg, about 50 mg, about 55 mg, about 60 mg, about 65 mg, about 70 mg, about 100 mg, about 125 mg, about 150 mg, about 175 mg, about 200 mg, about 225 mg, or about 250 mg. In some embodiments, the plurality of haptics are configured to support the weight of the device. For reference, a natural crystalline lens of an eye has a weight of about 250 mg, though it is considered to weigh about 15-20 mg in aqueous when the buoyancy of the lens is taken into consideration. Similarly, a hydrophilic IOL has a hydrated weight of about 34 mg, and a hydrophobic IOL has a hydrated weight of about 14 mg, though both are considered to weigh about 3 mg or less when the buoyancy of the hydrophilic IOL or hydrophobic IOL are taken into consideration. Vazquez, et al., Journal of Ophthalmology, “Weight of Different Intraocular Lenses: Evaluation of Toricity, ocality, Design, and Material,” 2021, Article ID 6686700, https: / / doi.org / 10.1155 / 2021 / 6686700.

[0132] In some embodiments of the IOL device disclosed herein, each of the plurality of haptics extends smoothly from the anterior portion of the annular body. In some embodiments, at least one haptic or each of the plurality of haptics has a smooth surface along the entire length of the haptic. In some embodiments, the plurality of haptics are configured to be non-abrasive and / or non-irritating to the sulcus of an eye. In some embodiments, the plurality of haptics are configured to be non-abrasive and / or non-irritating to the cornea of an eye. In some embodiments, the amount of iris chaffing resulting from an implanted IOL device does not exceed or is substantially similar to an amount resulting from the implantation of a 3 piece IOL such as MA60AC IOL (registered product of Alcon Surgical). In some embodiments, the amount of deformation of the IOL device and / or the plurality of haptics in-vitro does not exceed or is substantially similar to an amount experienced by a 3 piece IOL such as MA60AC IOL(registered product of Alcon Surgical). In some embodiments, at least one haptic or each of the plurality of haptics comprises an eyelet for surgical suturing, said eyelet being sufficient for allowing a 10-0 proline or vortex suture to pass through it.

[0133] In some embodiments of the IOL device disclosed herein, a single haptic of the plurality of haptics has a tensile strength in the range of between about 10-80 MPa. For example, in some embodiments, a single haptic of the plurality of haptics has a tensile strength in the range of between about 10-15 MPa, about 10-20 MPa, about 15-20 MPa, about 15-25 MPa, about 20-25 MPa, about 20-30 MPa, about 25-30 MPa, about 25-35 MPa, about 30-35 MPa, about 30-40 MPa, about 35-40 MPa, about 35-45 MPa, about 40-45 MPa, about 40-50 MPa, about 45-50 MPa, about 45-55 MPa, about 50-55 MPa, about 50-60 MPa, about 55-60 MPa, about 55-65 MPa, about 60-65 MPa, about 60-70 MPa, about 65-70 MPa, about 65-75 MPa, about 70-75 MPa, about 70-80 MPa, or about 75-80 MPa, such as a tensile strength of about 10 MPa, about 15 MPa, about 20 MPa, about 25 MPa, about 30 MPa, about 35 MPa, about 40 MPa, about 45 MPa, about 50 MPa, about 55 MPa, about 60 MPa, about 65 MPa, about 70 MPa, about 75 MPa, or about 80 MPa.

[0134] In some embodiments of the IOL device disclosed herein, a single haptic of the plurality of haptics has a stiffness in the range of between about 50-100 N / m2. For example, in some embodiments, a single haptic of the plurality of haptics has a stiffness in the range of between about 50-55 N / m2, about 50-60 N / m2, about 55-60 N / m2, about 55-65 N / m2, about 60-65 N / m2, about 60-70 N / m2, about 65-70 N / m2, about 65-75 N / m2, about 70-75 N / m2, about 70-80 N / m2, about 75-80 N / m2, about 75-85 N / m2, about 80-85 N / m2, about 80-90 N / m2, about 85-90 N / m2, about 85-95 N / m2, about 90-95 N / m2, about 90-100 N / m2, or about 95-100 N / m2, such as a stiffness of about 50 N / m2, about 55 N / m2, about 60 N / m2, about 65 N / m2, about 70 N / m2, about 75 N / m2, about 80 N / m2, about 85 N / m2, about 90 N / m2, about 95 N / m2, or about 100 N / m2.

[0135] In some embodiments of the IOL device disclosed herein, the plurality of haptics support a weight in the range of between about 10-125 mg. For example, in some embodiments, the plurality of haptics support a weight in the range of between about 10-30 mg, about 10-50 mg, about 10-70 mg, about 10-90 mg, about 10-110 mg, about 20-40 mg, about 20-60 mg, about 20-80 mg, about 20-100 mg, about 20-120 mg, about 30-50 mg, about 30-70 mg, about 30-90 mg, about 30-110 mg, about 40-60 mg, about 40-80 mg, about 40-100 mg, about 40-120 mg, about 50-75 mg, about 50-95 mg, about 50-115 mg, about 50-125 mg, about 60-85 mg, about 60-105 mg, about 60-125 mg, about 75-95 mg, about 75-115 mg, about 75-125 mg, about 85-105 mg, about 80-125 mg, about 90-100 mg, about 90-110 mg, about 90-125 mg, about 100-115 mg, or about 100-125 mg, such as support a weight of about 5.0 mg, about 10 mg, about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg,about 40 mg, about 45 mg, about 50 mg, about 55 mg, about 60 mg, about 65 mg, about 70 mg, about 75 mg, about 80 mg, about 85 mg, about 90 mg, about 95 mg, or about 100 mg.

[0136] In some embodiments of the IOL device disclosed herein, two diametrically opposed haptics allow radially-directed compression in the range of between about 5.0-15.0 mm, for example about 5.0-10.0 mm.

[0137] In some embodiments of the IOL device disclosed herein, the three trigonally positioned haptics allow radially-directed compression in the range of between about 3.0-15.0 mm, for example about 3.0-8.0 mm.

[0138] In some embodiments of the IOL device disclosed herein, the four equally spaced haptics allow radially-directly compression in the range of between about 1.0-15.0 mm, for example about 3.0-15.0 mm or about 1.0-6.0 mm.

[0139] In some embodiments of the IOL device disclosed herein, the anterior opening has at least one dimension sufficiently large to permit the insertion of an IOL. In some embodiments, the anterior opening has at least one dimension sufficiently large to permit the insertion of an IOL with a radius in the range of between about 4.0-8.0 mm. In some embodiments, the anterior opening has a circular shape. In some embodiments, the anterior opening has a diameter that is in the range of between about 2.0-8.0 mm, for example about 3.0-8.0 mm. For example, in some embodiments, the anterior opening has a diameter that is in the range of between about 3-4 mm, about 3-5 mm, about 3-6 mm, about 3-7 mm, about 4- 5 mm, about 4-6 mm, about 4-7 mm, about 4-8 mm, about 5-6 mm, about 5-7 mm, about 5-8 mm, about 6-7 mm, about 6-8 mm, or about 7-8 mm, such as a diameter of about 3.0 mm, about 4.0 mm, about 5.0 mm, about 6.0 mm, about 7.0 mm, or about 8.0 mm. In some embodiments, the posterior portion overlaps a portion of the anterior opening. In some embodiments, the posterior portion radially overlaps 5-50% of the anterior opening. In some embodiments, the anterior opening comprises a rim having a squared edge, a rounded edge, or a tapered edge. In some embodiments, the anterior opening is larger than the posterior opening.

[0140] In some embodiments of the IOL device disclosed herein, the posterior opening has at least one dimension sufficiently small to prevent the insertion of an IOL. In some embodiments, the posterior opening has at least one dimension sufficiently small to prevent an inserted IOL from falling into the vitreous upon implantation into the eye of a subject. In some embodiments, the posterior opening has at least one dimension sufficiently small to prevent the insertion of a collapsed, compressed and / or folded IOL. In some embodiments, the posterior opening has a smaller dimension than the anterior opening. In someembodiments, the posterior opening is not wide enough to block the optical axis. In some embodiments, the posterior opening has a circular shape. In some embodiments, the posterior opening is smaller than the anterior opening in the range of between about 10-70%. For example, in some embodiments, the posterior opening is smaller than the anterior opening in the range of between about 10-15 %, about 10-20 %, about 15-20 %, about 15-25 %, about 20-25 %, about 20-30 %, about 25-30 %, about 25-35 %, about 30-35 %, about 30-40 %, about 35-40 %, about 35-45 %, about 40-45 %, about 40-50 %, about 45-50 %, about 45-55 %, about 50-55 %, about 50-60 %, about 55-60 %, about 55-65 %, about 60-65 %, about 60- 70 %, or about 65-70 %. In some embodiments, the posterior opening is smaller than the anterior opening by about 10 %, about 15 %, about 20 %, about 25 %, about 30 %, about 35 %, about 40 %, about 45 %, about 50 %, about 55 %, about 60 %, about 65 %, or about 70 %. In some embodiments, the posterior opening has a diameter that is in the range of between about 1.5-5.5 mm. For example, in some embodiments, the posterior opening has a diameter in the range of between about 1.5-2.0 mm, about 1.5-2.5 mm, about 1.5-3.5 mm, about 2.0- 2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, about 3.0-3.5 mm, about 3.5-4.0 mm, about 3.5-4.5 mm, about 4.0-4.5 mm, about 4.5-5.0 mm, about 4.5-5.5 mm, or about 5.0-5.5 mm, such as a diameter of about 2.0 mm, about 3.0 mm, about 3.5 mm, about 4.0 mm, about 4.5 mm, about 5.0 mm, or about 5.5 mm. In some embodiments, the posterior opening comprises a rim having a squared edge, a rounded edge, or a tapered edge.

[0141] In some embodiments of the IOL device disclosed herein, the anterior portion comprises a gutter, track, well, or reservoir is proximal to the anterior opening. In some embodiments, the gutter, track, well, or reservoir, is suitable for containing and / or eluting a drug component, optionally comprising fenestrations that allow for drug elution. In some embodiments, the annular volume of a gutter may be fully or partially filled with said drug component. For example, in some embodiments, gutter may be used to carry and / or deliver a payload of anti-VEGF treatments, such as by holding a gel and / or pellet of medication that is inserted periodically, in the treatment of AMD. For example, in some embodiments, gutter may be used to carry and / or deliver a payload of a drug for the treatment of glaucoma. In such an embodiment, the fillable gutter may be rigid or it may instead be inflatable and / or deformable. Alternatively, an annulus or a container containing the drug component may be attached or clipped to the interior or exterior of the gutter, or the annulus or container containing the drug component may be threaded into the gutter. In some embodiments, the gutter, track, well, or reservoir, may have an anti-lens epithelial cell proliferation coating and / or the gutter, track, well, or reservoir, may comprise of a material which allows removalof proliferating cells. In some embodiments, the gutter, track, well, or reservoir has a diameter of about 0.1-3.0 mm. For example, in some embodiments, the gutter, track, well, or reservoir has a diameter that is in the range of between about 0.1-0.5 mm, about 0.1-1.0 mm, about 0.1-1.5 mm, about 0.1-2.0 mm, about 0.1-2.5 mm, about 0.1-3.0 mm, about 0.5-1.0 mm, about 0.5-1.5 mm, about 0.5-2.0 mm, about 0.5-2.5 mm, about 0.5-3.0 mm, about 1.0- 1.5 mm, about 1.0-2.0 mm, about 1.0-2.5 mm, about 1.0-3.0 mm, about 1.5-2.0 mm, about 1.5-2.5 mm, about 1.5-3.0 mm, about 2.0-2.5 mm, about 2.0-3.0 mm, or about 2.5-3.0 mm, such as a diameter of about 0.1 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, or about 3.0 mm. In some embodiments, the gutter, track, well, or reservoir has a volume capacity of about 9 microliters.

[0142] In some embodiments of the I0L device disclosed herein, the annular body is hydrophobic. In some embodiments, the plurality of haptics is hydrophobic. In some embodiments, the device is hydrophobic.

[0143] In some embodiments of the IOL device disclosed herein, the annular body is hydrophilic. In some embodiments, the plurality of haptics is hydrophilic. In some embodiments, the device is hydrophilic.

[0144] In some embodiments of the IOL device disclosed herein, a collapsed, compressed and / or folded device has a length of about 10-20 mm, such as 12 mm, 13 mm, 14 mm, 15 mm, 16 mm, 17 mm, or 18 mm. In some embodiments, the collapsed, compressed and / or folded device has a length of about 14 mm.

[0145] In some embodiments, provided herein is an intraocular lens system, comprising an intraocular lens (IOL) within the cavity of the intraocular lens device as disclosed herein. In some embodiments, the intraocular lens system has a diameter of less than about 2.2 mm when collapsed, compressed and / or folded. In some embodiments, the intraocular lens system has a length of about 14 mm when collapsed, compressed and / or folded. In some embodiments, the IOL is hydrophobic. In some embodiments, the IOL is hydrophilic. In some embodiments, the optical diameter of the IOL is between about 10-15 mm. For example, in some embodiments, the optical diameter of the IOL is between about 4-6 mm, about 4-8 mm, about 4-10 mm, about 4-12 mm, about 6-8 mm, about 6-10 mm, about 6-12 mm, about 8-10 mm, about 8-12 mm, about 10-12 mm, about 10-15 mm, about 12-14 mm, about 12-15 mm, or about 14-15 mm. In some embodiments, the optical diameter of the IOLis 10-15 mm. In some embodiments, the intraocular lens device comprises 1, 2, or 3 IOLS. In some embodiments, the intraocular lens device contains no more than 1 or 2 IOLs.

[0146] In some embodiments, provided herein is an intraocular lens system, comprising an intraocular lens (IOL) and the intraocular lens device comprising the intraocular ring as disclosed herein. In some embodiments, the intraocular lens system has a diameter of less than about 2.2 mm when collapsed, compressed and / or folded. In some embodiments, the intraocular lens system has a length of about 10-15 mm when collapsed, compressed and / or folded. In some embodiments, the IOL is hydrophobic. In some embodiments, the IOL is hydrophilic. In some embodiments, the optical diameter of the IOL is between about 4-15 mm, for example, between about 4-6 mm, about 4-8 mm, about 4-10 mm, about 4-12 mm, about 6-8 mm, about 6-10 mm, about 6-12 mm, about 8-10 mm, about 8-12 mm, about 10-12 mm, about 10-15 mm, about 12-14 mm, about 12-15 mm, or about 14-15 mm. In some embodiments, the diameter of the IOL optic is about 4-8 mm; optionally 6-8 mm. In some embodiments, there is no gap between the IOL and an interior surface of the intraocular ring. In some embodiments, there is a gap between the IOL and an interior surface of the intraocular ring. In some embodiments, the gap between the IOL and an interior surface of the intraocular ring is within a range of about 0.01 and about 1.0 mm; optionally within a range of about 0.15-0.75 mm or about 0.25-0.5 mm, such as about 0.1 mm, about 0.2 mm, about 0.25 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm. In some embodiments, the intraocular lens device comprises 1, 2, or 3 IOLs. In some embodiments, the intraocular lens device contains no more than 1 or 2 IOLs.

[0147] In some embodiments, provided herein is a method of implanting an intraocular lens (IOL) into the eye of a subject, comprising: i) injecting the intraocular lens device as disclosed herein into an eye of a subject; optionally into a capsular bag of an eye of a subject; and ii) injecting an intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye. In some embodiments, provided herein is a method of implanting an intraocular lens (IOL) into the eye of a subject, comprising injecting the intraocular lens system as disclosed herein. In some embodiments, the IOL is hydrophobic. In some embodiments, the IOL is hydrophilic. In some embodiments, the method further comprises injecting a second intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye. In some embodiments, the method further comprises injecting a second intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye. In some embodiments, the optical diameter of the IOL is between about 10-15 mm. For example, in some embodiments, the opticaldiameter of the IOL is between about 4-6 mm, about 4-8 mm, about 4-10 mm, about 4-12 mm, about 6-8 mm, about 6-10 mm, about 6-12 mm, about 8-10 mm, about 8-12 mm, about 10-12 mm, about 10-15 mm, about 12-14 mm, about 12-15 mm, or about 14-15 mm. In some embodiments, a minimum incision length of the subject’s eye for implantation of the intraocular lens device or the intraocular lens system is about 2.2 mm. In some embodiments, a minimum incision length of the subject’s eye for implantation of the intraocular lens device or the intraocular lens system is between about 1.0-4.0 mm. In some embodiments, a minimum incision length of the subject’s eye for implantation of the intraocular lens device or the intraocular lens system is in the range of between about 1.5-2.0 mm, about 1.5-2.5 mm, about 2.0-2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, or about 3.0-3.5 mm. In some embodiments, a minimum incision length of the subject’s eye for implantation of the intraocular lens device or the intraocular lens system is about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, or about 3.5 mm.

[0148] In some embodiments, the IOL device is deformable for insertion into a capsular bag of an eye; optionally wherein the IOL device is deformable enough to be loaded into a cartridge for implantation. Upon implantation / insertion, the IOL device can then self-expand and / or unfold into its active form capable of receiving an IOL. In some embodiments, the device may be configured to self-expand either within or in the absence of an original capsular bag. In some embodiments, the IOL device and IOL are pre-packaged together prior to implantation, thereby forming an IOL system as disclosed herein, and are subsequently injected simultaneously into the eye of a patient.

[0149] In some embodiments, the surgical process to implant the IOL device has the option of being minimally invasive, as the device is collapsible, compressible, flexible, deformable, and / or foldable so as to reduce the amount of space required to accommodate it. In some embodiments the device is able to achieve a sufficient small volume and / or dimension to be loaded into an injectable cartridge for implantation. In some embodiments, the cartridge is injectable through a needle with a width as little as 2.4 mm. In some embodiments, the IOL device and / or the IOL system disclosed herein is able to achieve a sufficient small volume and / or dimension to be loaded into, and dispensed from, an A-, B-, C-, or D-sized cartridge or folded and manually inserted using forceps.

[0150] In some embodiments, the IOL device or IOL system is inserted into an eye lacking a capsular bag or having a damaged or defective capsular bag. In such instances, additional procedures can be employed to assist in securing the IOL device or IOL system in place within the eye of a subject, which can include the use of a de-roofed needle and a method of anchoring one or more haptics of the plurality of haptics into the sclera of the eye. In some embodiments, the method of implanting an intraocular lens (IOL) into the eye of a subject with a missing, damaged, and / or defective capsular bag may comprise of injecting an intraocular lens device into the eye of a subject; securing the intraocular lens device within the eye of the subject by employing a de-roofed needle and thread to externalize and affix a portion of two haptics of the plurality of haptics through the sclera of the eye of the subject; and injecting an intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye. In some embodiments, the method of implanting an intraocular lens (IOL) into the eye of a subject with a missing, damaged, and / or defective capsular bag may comprise of injecting an intraocular lens system into the eye of a subject, and securing the intraocular lens device within the eye of the subject by employing a deroofed needle and thread to externalize and affix a portion of two haptics of the plurality of haptics through the sclera of the eye of the subject.

[0151] In some embodiments, the de-roofed portion of the de-roofed needle has a length in the range of between about 10-90% of the overall length of the de-roofed needle. In some embodiments, an overall length of the de-roofed needle is at least 50% of the total needle length, for example, at least 60%, at least 70%, at least 80%, at least 90%, or at least 95% of the total needle length. In some embodiments, the de-roofed portion of the de-roofed needle spans the interior portion of the needle, with full, intact needle portions of the needle at both endpoints. In some embodiments, the de-roofed portion of the de-roofed needle spans the interior portion of the needle and extends to one endpoint, with a full, intact needle portion at one endpoint. For example, in some embodiments, the length of the de-roofed portion of the de-roofed needle is shorter than the overall length of the de-roofed needle in the range of between about 10-15 %, about 10-20 %, about 10-30 %, about 10-40 %, about 10-50 %, about 10-60 %, about 10-70 %, about 10-80 %, about 10-90 %, about 20-30 %, about 20-40 %, about 20-50 %, about 20-60 %, about 20-70 %, about 20-80 %, about 20-90 %, about 30- 40 %, about 30-50 %, about 30-60 %, about 30-70 %, about 30-80 %, about 30-90 %, about 40-50 %, about 40-60 %, about 40-70 %, about 40-80 %, about 40-90 %, about 50-60 %, about 50-70 %, about 50-80 %, about 50-90 %, about 60-70 %, about 60-80 %, about 60-90 %, about 70-80 %, about 70-90 %, or about 80-90 %. In some embodiments, the length ofthe de-roofed portion is shorter than the overall length of the de-roofed needle by about 10 %, about 20 %, about 30 %, about 40 %, about 50 %, about 60 %, about 70 %, about 80 %, or about 90 %.

[0152] In some embodiments, the de-roofed portion comprises an arclength that is in the range of between about 10-70% of the outer circumference and / or perimeter of a crosssection of the de-roofed needle. For example, in some embodiments, said arclength is a percentage of the outer circumference and / or perimeter of a cross-section of the de-roofed needle in the range of between about 10-15 %, about 10-20 %, about 15-20 %, about 15-25 %, about 20-25 %, about 20-30 %, about 25-30 %, about 25-35 %, about 30-35 %, about 30- 40 %, about 35-40 %, about 35-45 %, about 40-45 %, about 40-50 %, about 45-50 %, about 45-55 %, about 50-55 %, about 50-60 %, about 55-60 %, about 55-65 %, about 60-65 %, about 60-70 %, about 65-70 %, or about 20-40 %. In some embodiments, the length of the de-roofed portion is shorter than the overall length of the de-roofed needle by about 10 %, about 15 %, about 20 %, about 25 %, about 30 %, about 35 %, about 40 %, about 45 %, about 50 %, about 55 %, about 60 %, about 65 %, or about 70 %.

[0153] In some embodiments, an overall length of the de-roofed needle is between about2.5-4.0 mm. In some embodiments, an overall length of the de-roofed needle is in the range of between about 2.5-3.0 mm, about 2.5-3.5 mm, about 3.0-3.5 mm, about 3.0-4.0 mm, or about 3.5-4.0 mm. In some embodiments, an overall length of the de-roofed needle is about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, or about 4.0 mm.

[0154] In some embodiments, a length of the de-roofed portion of the de-roofed needle is between about 0.5-2.5 mm. In some embodiments, a length of the de-roofed portion of the de-roofed needle is in the range of between about 0.5-1.0 mm, about 0.5-1.5 mm, about 0.5- 2.0 mm, about 1.0-1.5 mm, about 1.0-2.0 mm, about 1.0-2.5 mm, about 1.5-2.0 mm, about1.5-2.5 mm, or about 2.0-2.5 mm. In some embodiments, a length of the de-roofed portion of the de-roofed needle is about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, or about 2.5 mm.

[0155] In some embodiments, the thickness of the de-roofed needle may be 30, 29, 28, 27, 26, 25, 24, 23, 22, 21, or 20 gauge.

[0156] In some embodiments, the wall thickness of the de-roofed needle is between about 0.05-0.20 mm. In some embodiments, the wall thickness of the de-roofed needle is in the range of between about 0.05-0.10 mm, about 0.05-0.15 mm, about 0.10-0.15 mm, about 0.10- 0.20 mm, or about 0.15-0.20 mm. In some embodiments, the wall thickness of the de-roofed needle is about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.10 mm, about 0.11 mm, about 0.12 mm, about 0.13 mm, about 0.14 mm, about 0.15 mm, about 0.16 mm, about 0.17 mm, about 0.18 mm, about 0.19 mm, or about 0.20 mm.

[0157] In some embodiments, the thread thickness allowed by the de-roofed needle is between about 0.05-0.20 mm. In some embodiments, the thread thickness allowed by the deroofed needle is in the range of between about 0.05-0.10 mm, about 0.05-0.15 mm, about 0.10-0.15 mm, about 0.10-0.20 mm, or about 0.15-0.20 mm. In some embodiments, the thread thickness allowed by the de-roofed needle is about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.10 mm, about 0.11 mm, about 0.12 mm, about 0.13 mm, about 0.14 mm, about 0.15 mm, about 0.16 mm, about 0.17 mm, about 0.18 mm, about 0.19 mm, or about 0.20 mm.

[0158] In one exemplary embodiment, a de-roofed needle with a thickness of 25 gauge may have an outer diameter of about 0.515 mm, an inner diameter of about 0.153 mm, and a wall thickness of about 0.178 mm. In an embodiment wherein 40 % of said needle is deroofed, then the outer circumference gap may be about 0.647 mm and the internal circumference gap may be about 0.192 mm, allowing for a thread thickness that is between about 0.150 mm to 0.180 mm. In another embodiment wherein 20 % of said needle is deroofed, then the outer circumference gap may be about 0.323 mm and the internal circumference gap may be about 0.096 mm, allowing for a thread thickness of about 0.08 mm. In yet another exemplary embodiment, a de-roofed needle with a thickness of 23 gauge may have an outer diameter of about 0.642 mm, an inner diameter of about 0.337 mm, and a wall thickness of about 0.152 mm. In an embodiment wherein 40 % of said needle is deroofed, then the outer circumference gap may be about 0.807 mm and the internal circumference gap may be about 0.424 mm, allowing for a thread thickness that is between about 0.150 mm to 0.3 mm. In another embodiment wherein 20 % of said needle is deroofed, then the outer circumference gap may be about 0.404 mm and the internal circumference gap may be about 0.212 mm, allowing for a thread thickness that is between about 0.150 mm to 0.2 mm.

[0159] In some embodiments, provided herein is a method of forming an opening sufficient for insertion of an IOL haptic, comprising piercing or opening a portion of thecontinuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring of the intraocular lens device as disclosed herein. In some embodiments, the splitting or opening is performed via use of a scalpel and / or grasping instrument, such as pair of forceps or tweezers. In some embodiments, 1-6 piercings or openings sufficient to insert an IOL haptic are formed along the circumference of the intraocular ring of said intraocular lens device; optionally wherein 1, 2, 3, 4, 5, or 6, such as 2 or 4, piercings or openings sufficient to insert an IOL haptic are formed along the circumference of the intraocular ring of said intraocular lens device, wherein the positions of the piercings or openings are variable.

[0160] In some embodiments, provided herein is a method of preparing the intraocular lens system comprising the intraocular lens device comprising the intraocular ring as disclosed herein, comprising piercing or opening a portion of the continuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring of said intraocular lens device sufficient to insert an IOL haptic. In some embodiments, the splitting or opening is performed via use of a scalpel and / or grasping instrument, such as pair of forceps or tweezers. In some embodiments, 1-6 piercings or openings sufficient to insert an IOL haptic are formed along the circumference of the intraocular ring of said intraocular lens device; optionally wherein 1, 2, 3, 4, 5, or 6, such as 2 or 4, piercings or openings sufficient to insert an IOL haptic are formed along the circumference of the intraocular ring of said intraocular lens device, wherein the positions of the piercings or openings are suited to the particular needs of the patient.

[0161] FIG. 1A and FIG. IB depict anterior oblique views of the intraocular lens (IOL) device 100, in accordance with some embodiments. The IOL device 100 comprises an annular body 102 having an anterior opening 104 located at the anterior portion of the annular body 102 and a posterior opening 106 located at the posterior portion of the annular body 102. The posterior opening 106 is positioned opposite (antipode) to the anterior opening 104, and both the anterior opening 104 and the posterior opening 106 are centered along an optical axis 112. Upon implantation of the IOL device 100 into an eye of a patient, the IOL device 100 is to be positioned such that the anterior opening 104 faces towards the cornea of the patient’s eye and the posterior opening 106 faces towards the posterior chamber of the patient’s eye. In some embodiments, the IOL device 100 further comprises a plurality of lateral openings 108 that perforate the annular body 102, which are positioned between the anterior opening 104 and the posterior opening 106. As depicted in FIG. 1A and FIG. IB, in some embodiments, the IOL device 100 may be perforated with four lateral openings 108.Each lateral opening 108 is positioned such that it may receive a haptic of an intraocular lens (IOL) upon insertion of the IOL into the IOL device 100. In the embodiments depicted in FIG. 1A and FIG. IB, each lateral opening 108 is a rectangularly-shaped opening oriented perpendicularly to its adjacent openings and positioned along the equator of the annular body 102. According to some embodiments, the openings being substantially 90 degrees apart from each other helps rotate and align toric IOLS. The IOL device 100 further comprises a plurality of haptics 110, such as the two haptics 110 depicted in FIG. 1A and FIG. IB, which originate proximately to the anterior opening 104 and extend from the anterior portion of the annular body 102. In some embodiments, each of the plurality of haptics 110, including each of their respective points of origination from the anterior portion, have a smooth surface. In the embodiments depicted in FIG. 1A and FIG. IB, the plurality of haptics 110 is two diametrically-opposed haptics 110 that are rotationally symmetric with each other. In some embodiments, the annular body 102 of the IOL device 100 has a smooth and / or continuous surface (102A), as depicted in FIG. 1A. In some embodiments, the annular body 102 of the IOL device 100 has a mesh surface (102B), as depicted in FIG. IB.

[0162] FIG. 2A and FIG. 2B depict anterior oblique views of the intraocular lens (IOL) system 200, in accordance with some embodiments. The IOL system 200 comprises a complex of the IOL device 100 and an intraocular lens (IOL). As depicted in FIG. 2A and FIG. 2B, the IOL comprises an IOL optic 202 and a plurality of IOL haptics 204. The IOL optic 202 is housed within the interior cavity of the annular body 102 and is visible through the anterior opening 104. In some embodiments, such as depicted in FIG. 2A and FIG. 2B, the IOL optic 202 is larger than the anterior opening 104. In some embodiments, the IOL device 100 may also accommodate an IOL having an IOL optic 202 that is substantially the same size or smaller than the anterior opening 104, depending on the ophthalmic needs of the patient. The IOL haptics 204 extend from the edge of the IOL optic 202 and through the lateral openings 108. The dimensions of the lateral openings 108 are sufficient to at least restrict the movement of the IOL haptics 204 within the IOL device 100. With the IOL haptics 204 extended through the lateral openings 108, the IOL optic 202 is centered along the optical axis 112 and the IOL is secured so as not to rotate freely within the device 100 or become dislodged. In some embodiments, the annular body 102 of the IOL device 100 has a smooth and / or continuous surface (102A), as depicted in FIG. 2A. In some embodiments, the annular body 102 of the IOL device 100 has a cage-like surface (102C), as depicted in FIG. 2B

[0163] FIG. 3A depicts an anterior plan view of the intraocular lens (IOL) device 100, inaccordance with some embodiments. As depicted in FIG. 3A, in some embodiments, the anterior portion of the annular body 302 comprises a substantially circular shape from an anterior plan perspective, which may be quantified and / or described by a diameter spanning an outermost perimeter 308 of the anterior portion of the annular body 302. In some embodiments, such as depicted in FIG. 3A, the outermost perimeter 308 is equivalent to an outermost circumference. In some embodiments, the IOL device 100 may comprise alternative shapes when viewed from an anterior plan perspective, such as an ellipse. In such an elliptical embodiment, a dimension of the anterior portion of the annular body 302 may instead be quantified and / or described by at least a major axis and a minor axis of the ellipse. As depicted in the embodiment of FIG. 3A, the anterior portion of the annular body 302 is visible and extends from the anterior opening 104 to the outermost perimeter 308 of the anterior portion of the annular body 302. As depicted in the embodiment of FIG. 3A, the posterior opening 106 and the anterior opening 104 are aligned along the optical axis 112 and form concentric circles, with the posterior opening 106 being distal to the anterior opening 104. The anterior opening 104 is larger than (e.g., encircles) the posterior opening 106 and, from the anterior plan perspective, creates an annulus comprising an exposed portion of the posterior portion 304. In other embodiments, the respective diameters of the anterior opening 104 and / or the posterior opening 106 may be increased and / or decreased depending on the ophthalmic needs of the patient. In some embodiments, the anterior opening 104 has at least one dimension larger than the posterior opening 106.

[0164] In some embodiments, such as depicted in FIG. 3A, the rectangular lateral openings 108 may “jut into” the anterior portion of the annular body 302, when viewed from the anterior plan view perspective. In some embodiments, the radial distance by which the lateral openings 108 may extend into the anterior portion of the annular body 302 and / or towards the optical axis 112 may depend upon the dimensions of the lateral openings 108 and the curvature of the annular body of the intraocular lens (IOL) device 100. In some embodiments, such as depicted in FIG. 3A, the proximal anterior sides of the plurality of lateral openings 108 match the contour of a line of latitude around the anterior portion of the annular body 302 and may substantially match the curvature of the outermost perimeter 308. In some embodiments, such as the embodiment of FIG. 2B, the plurality of lateral openings 108 may instead be substantially two-dimensional and / or comprised of one or more sides that appear to be substantially linear at least from the anterior plan perspective. In some embodiments, one or more edges, such as each edge, among the plurality of lateral openings 108 may be tapered, beveled, square, or round. For example, in some embodiments, such asdepicted by FIG. 3A, an edge, such as each edge, of the plurality of lateral openings 108 is square.

[0165] In some embodiments, the IOL device 100 has two haptics 110, for example two diametrically-opposed haptics 110, such as depicted in FIG. 3A. In some embodiments, such as depicted in FIG. 3A, the haptics 110 extend with radial symmetry from the anterior portion of the annular body 302, beginning substantially parallel to each other before continuing in a parabolic curve. In some embodiments, the region of peak convexity of a haptic 110 may align with a lateral opening 108. For example, as depicted in FIG. 3A, the regions of peak convexity of both haptics 110 may be substantially aligned with a pair of opposite lateral openings 108. In some embodiments, the regions of peak convexity of one or more haptics 110 may not align with one or more lateral openings 108, depending upon the shape of the haptics 110, the number of the lateral openings 108, and / or the size of the lateral openings 108.

[0166] In some embodiments, such as depicted in FIG. 3A, the points of origin from which the plurality of haptics 110 extend are rotationally and bilaterally symmetrical with each other. In this embodiment, the points of origin are about halfway across the radial distance from the rim of the anterior opening 104 to the outer perimeter 308. Furthermore, in this embodiment, the points of origin are located proximately to opposite lateral openings 108. In other embodiments, the plurality of points of origin may appear uniformly-spaced along any single line of latitude located between the rim of the anterior opening 104 to the outermost perimeter 308. In substantially circular embodiments, such as is depicted in FIG. 3A, the points of origin may be located along a circle that is concentric with the anterior opening 104.

[0167] FIG. 3B depicts a cross-sectional side view of the IOL device 100 rotated along line 3B-3B of FIG. 3A, in accordance with some embodiments. As depicted in FIG. 3B, in some embodiments, the annular body, comprised of an anterior portion 302 and a posterior portion 304, may have a substantially donut-shaped and / or toroidal profile. As depicted in the embodiment of FIG. 3B, both the anterior portion of the annular body 302 and the posterior portion of the annular body 304 are visible and connect at a midpoint plane 306, which is located between the anterior opening 104 and posterior opening 106. The midpoint plane 306 is centered around and orthogonal to the optical axis 112. In the embodiment of FIG. 3B, the anterior portion 302 and posterior portion 304 are substantially bilaterally symmetrical across the midpoint plane 306, although the anterior opening 104 is larger than the posterior opening 106. Furthermore, in this embodiment, the midpoint plane 306 roughlycontains the outermost perimeter 308 and substantially bisects the lateral openings 108 longitudinally. In some embodiments, the shapes of the anterior portion 302 and posterior portion 304 may be independently specialized and / or distinct such that they are not substantially bilaterally symmetric across the midpoint plane 306. In some embodiments, the placement of the lateral openings 108 may not coincide with the midpoint plane 306 and / or the outermost perimeter 308. For example, in some embodiments, the lateral openings 108 may be positioned above or below the midpoint plane 306 and / or the outermost perimeter 308. The radius of curvature, or the radius of a circle that best fits a curve, of the interior surface of the annular body of the IOL device 100 may vary substantially across embodiments. Additionally, some embodiments may comprise of a plurality of curvatures in their interior surfaces.

[0168] FIG. 3C depicts a posterior plan view of the intraocular lens (IOL) device 100, in accordance with some embodiments. As depicted in FIG. 3C, in some embodiments, the posterior portion of the annular body 304 comprises a substantially circular shape from a posterior plan perspective, which may be quantified and / or described by a diameter spanning an outermost perimeter 308 of the posterior portion of the annular body 304. In the example of FIG. 3A, the outermost perimeter 308 is equivalent to an outermost circumference. Other embodiments of IOL device 100 may comprise alternative shapes when viewed from an anterior plan perspective, such as an ellipse. In such an elliptical embodiment, a dimension of the posterior portion of the annular body 304 may instead be quantified and / or described by at least a major axis and a minor axis of the ellipse. As depicted in the embodiment of FIG. 3C, the posterior portion of the annular body 304 is visible and extends from the posterior opening 106 to the outermost perimeter 308 of the posterior portion the annular body 304. As depicted in the embodiment of FIG. 3C, the posterior opening 106 and the anterior opening 104 are aligned along the optical axis 112 and form concentric circles, with the anterior opening 104 being distal to the posterior opening 106 from the perspective as shown.. In some embodiments, such as depicted in FIG. 3C, the posterior portion 304 obscures the edge of the anterior opening 104. In some embodiments, such as depicted in FIG. 3C, the rectangular lateral openings 108 may “jut into” the posterior portion 304. In some embodiments, the radial distance by which the lateral openings 108 may extend into the posterior portion 304 and / or towards the optical axis 112 may depend upon the size of the lateral openings 108 and the curvature of the annular body of the intraocular lens (IOL) device 100. In some embodiments, such as depicted in FIG. 3C, the proximal posterior sides of the plurality of lateral openings 108 match the contour of a line of latitude around theposterior portion 304 and may substantially match the curvature of the outermost perimeter 308. In some embodiments, such as the embodiment of FIG. 2B, the plurality of lateral openings 108 may be substantially two-dimensional and / or comprised of one or more sides that are substantially linear at least from the posterior plan perspective. From the posterior plan view of FIG. 3C, the points of origin of the haptics 110 are obscured.

[0169] FIG. 4A depicts an anterior plan view of an intraocular lens (IOL) system 200, comprised of an intraocular lens (IOL) device 100, such as detailed in FIG. 3A, in combination with an intraocular lens (IOL), which comprises of an IOL optic 202 and a plurality of IOL haptics 204. In some embodiments, such as depicted in FIG. 4A, an IOL haptic 204 extends through a lateral opening 108, which secures the IOL within the IOL device 100. In some embodiments, such as depicted in FIG. 4A, each IOL haptic 204, such as the two diametrically-opposed IOL haptics 204 that are rotationally symmetric with each other, extend through two opposing lateral openings 108, which secures the IOL within the IOL device 100. In some embodiments, such as depicted in FIG. 4A (and as depicted in FIG. 2A and FIG. 2B), the device haptics 110 and the IOL haptics 204 are oriented perpendicularly to each other. In some embodiments, the device haptics 110 and the IOL haptics 204 may be oriented in different arrangements. In some embodiments, the IOL haptics 204 extend from the edge of the IOL optic 202 and through the lateral openings 108. In some embodiments, the dimensions of the lateral openings 108 are sufficient to restrict the movement of the IOL haptics 204 within the IOL device 100. In some embodiments, with the IOL haptics 204 extended through the lateral openings 108, the IOL optic 202 is centered along the optical axis 112 and the IOL is secured so as not to rotate freely within the device 100 or become dislodged. In some embodiments, the posterior portion 304 may partially occlude light that enters the anterior opening 104 and passes through the IOL optic 202.

[0170] FIG. 4B depicts a cross-sectional side view of the IOL system 200 rotated along line 4B-4B of FIG. 4A. In some embodiments, such as depicted in the embodiment of FIG. 4B, the IOL optic 202 is located substantially at the midpoint plane 306. In some embodiments, the lateral openings 108 and the IOL optic 202 do not coincide with the midpoint plane 306 and / or the outermost perimeter 308. For example, in some embodiments, the lateral openings 108 and the IOL optic 202 may be positioned above or below the midpoint plane 306 and / or the outermost perimeter 308. In some the embodiment, such as depicted in FIG. 4B, the IOL optic 202 extends substantially equally into both the anterior portion 302 and the posterior portion 304. In other embodiments, the IOL optic 202 may be located substantially or completely within the anterior portion 302 or the posterior portion304. In some the embodiments, such as depicted in FIG. 4A and FIG. 4B, the IOL optic 202 has a larger diameter than the anterior opening 104. In some embodiments, the IOL device 100 may accommodate an IOL having an IOL optic 202 that is substantially the same size or smaller than the anterior opening 104, depending on the ophthalmic needs of the patient. In some the embodiments, such as depicted in FIG. 4B, the IOL comprises of a uniform thickness across both the IOL optic 202 and the IOL haptics 204. In some embodiments, such as depicted in FIG. 4B, the thickness of the IOL occupies roughly half the width of the lateral openings 108. In some embodiments, the thickness of the IOL may vary depending upon the ophthalmic needs of the patient, while width of the lateral openings 108 may be constricted or expanded in order to properly accommodate a particular IOL haptic 204.

[0171] FIGS. 5A-5D depict anterior oblique views of intraocular lens (IOL) devices with lateral opening variations 500, in accordance with some embodiments. FIG. 5A shows an embodiment of the IOL device 500 with six rectangular lateral openings evenly distributed along the equator of the annular body of the IOL device 500. FIG. 5B shows an embodiment of the IOL device 500 with eight rectangular lateral openings evenly distributed along the equator of the annular body of the device 500. FIG. 5C shows an embodiment of the IOL device 500 with trapezoidal lateral openings. The orientation of these trapezoidal lateral openings may alternate as depicted in FIG. 5C, or the orientation of the plurality of lateral openings may remain uniform throughout the annular body of the device. FIG. 5D shows an embodiment of the IOL device 500 comprising of both elliptical lateral openings and rectangular lateral openings. The arrangement of the elliptical lateral openings and the rectangular lateral openings may alternate as depicted in FIG. 5D, or the arrangement of lateral openings may comprise of alternative patterns, ratios, and / or combinations of different shapes. In some embodiments, the lateral opening may have an elliptical, circular, arcuate, triangular, rectangular, and / or polygonal shape.

[0172] Some embodiments may possess one or more combinations of any of the features depicted within FIGS. 5A-5D. For example, in some embodiments, the IOL device 500 may be perforated with a plurality of lateral openings substantially exceeding four lateral openings, while in other embodiments the IOL device 500 may only contain one, two, or three lateral openings. In some embodiments, the lateral openings 108 may be distributed throughout the annular body, for example, arranged along an non-equatorial latitude and / or a plurality of latitudes of the annular body of the device. In some embodiments, the lateral openings may have radial and / or bilateral symmetry, while other embodiments may lack radial and / or bilateral symmetry. These variations in shape and / or orientation of the lateralopenings may facilitate proper orientation and / or proper alignment of the IOL haptics 204, thereby providing correct orientation, correct placement, and / or a secure fit of the IOL optic 202 within the IOL device 100. In some embodiments, where the lateral openings 108 overlap with the outermost perimeter 308 but are not positioned symmetrically across it, for example, perforating more of the anterior portion than the posterior portion, then an overhanging portion of the posterior portion 304 may be visible from an anterior plan view. In some embodiments, where the lateral openings 108 overlap with the outermost perimeter 308 but are not positioned symmetrically across it, for example, perforating more of the posterior portion than the anterior portion, then an overhanging portion of the anterior portion 304 may be visible from a posterior plan view.

[0173] FIG. 6A depicts an anterior plan view of an intraocular lens (IOL) system 600 lacking a plurality of lateral openings, in accordance with some embodiments. FIG. 6B depicts a cross-sectional side view of the IOL system 600 rotated along line 6B-6B of FIG. 6A. Similarly to the IOL system 200 depicted in FIG. 4A and FIG. 4B, the embodiment depicted in FIG. 6A and FIG. 6B comprises an anterior opening 104, a posterior opening 106, haptics 110, an anterior portion 302, a posterior portion 304, and an IOL comprising of an IOL optic 202 and a plurality of IOL haptics 204. In some embodiments, the annular body of IOL device of the IOL system 600 comprises a single, continuous annular body without any lateral openings 108. Further, the IOL device of the IOL system 600 comprises one or more interior ridges 602, which may be configured to provide support or otherwise affix an IOL within the IOL device. In the embodiment depicted in FIG. 6B, the IOL haptics 204 may be flexible such that each bends radially inward towards the IOL optic and configured such that each IOL haptic 204 can slide into and / or between the two interior ridges 602. In some embodiments, the ridges 602 can be located in the anterior portion 302. In some embodiments, the ridges 602 can be located in the posterior portion 304. In the embodiment depicted in FIG. 6B, the ridges 602 are located substantially at the midpoint plane 306 of the IOL device, with one ridge 602 located in the anterior portion 302 and one ridge 602 located in the posterior portion 304. In some embodiments, an interior ridge 602 may extend completely around the annular body of the device as depicted in FIG. 6A, or an interior ridge 602 may be restricted to only a portion of the annular body of the IOL device. A plurality of interior ridges 602 may be overlapping, staggered, or non-overlapping. The longitudinal and / or latitudinal distances between the interior ridges 602 may be controlled to provide sufficient space to accommodate the IOL haptics 204.

[0174] FIG. 7A depicts an anterior plan view of an intraocular lens (IOL) system 700lacking a plurality of lateral openings, in accordance with some embodiments. FIG. 7B depicts a cross-sectional side view of the IOL system 700 rotated along line 7B-7B of FIG. 7A. Similarly to the IOL system 200 depicted in FIG. 4A and FIG. 4B, the embodiment depicted in FIG. 7A and FIG. 7B comprises an anterior opening 104, a posterior opening 106, haptics 110, an anterior portion 302, a posterior portion 304, and an IOL comprising of an IOL optic 202. In some embodiments, the IOL comprises a plurality of IOL tabs 704 to facilitate attachment of the IOL to the IOL device of the IOL system 700. In the embodiment of FIG. 7A, the IOL is shown to comprise of four evenly-spaced IOL tabs 704. In some embodiments, the annular body of IOL device of the IOL system 700 comprises a single, continuous annular body without any lateral openings 108. Further, the IOL device of the IOL system 700 comprises one or more interior ridges 702, which may be configured to provide support or otherwise affix an IOL within the IOL device. In the embodiment depicted in FIG. 7B, the IOL tabs 702 can be configured to be slid, inserted, and / or “clicked” into and / or between the two interior ridges 702. In some embodiments, the ridges 702 can be located in the anterior portion 302. In some embodiments, the ridges can be located in the posterior portion 304. In the embodiment depicted in FIG. 7B, the ridges 702 are located substantially at the midpoint plane 306 of the IOL device, with one ridge 702 located in the anterior portion 302 and one ridge 702 located in the posterior portion 304. In some embodiments, an interior ridge 702 may extend completely around the annular body of the device as depicted in FIG. 7A, or an interior ridge 702 may be restricted to only a portion of the annular body of IOL device. A plurality of interior ridges 702 may be overlapping, staggered, or non-overlapping. The longitudinal and / or latitudinal distances between the interior ridges 702 may be controlled to provide sufficient space to accommodate the IOL tabs 702.

[0175] FIG. 8A depicts an anterior oblique view of an intraocular lens (IOL) device 800 lacking a plurality of lateral openings, in accordance with some embodiments. FIG. 8B depicts an anterior plan view of the IOL device 800, and FIG. 8C depicts a cross-sectional side view of the IOL device 800 rotated along line 8C-8C of FIG. 8B. Similarly to the IOL device 100 depicted in FIG. 3A and FIG. 3B, the embodiment depicted in FIG. 8A, FIG. 8B, and FIG. 8C comprises an anterior opening 104, a posterior opening 106, haptics 110, an anterior portion 302, and a posterior portion 304.

[0176] In some embodiments, the IOL device 800 when viewed from the perspective of FIG. 8C comprises an exterior ridge 802. The exterior ridge 802 can be formed by the shape and / or curvature of the annular body of the device 800. The exterior ridge 802 can be definedby two additional planes, including a plane corresponding to an anterior cusp 804 of the exterior ridge 802, and a second plane corresponding to a posterior cusp 806 of the exterior ridge 802. The width of this exterior ridge can be controlled by varying the distance between the plane of the anterior cusp 804 and the plane of the posterior cusp 806. In the example depicted in FIG. 8C, a groove is formed on the interior of the exterior ridge, which may be used to retain a plurality of IOL haptics 204, or a plurality of IOL tabs 702 (such as in FIG. 7 A and FIG. 7B), of an IOL.

[0177] FIG. 9A depicts an anterior oblique view of an intraocular lens (IOL) device 900 comprising a vertical portion, in accordance with some embodiments. FIG. 9B depicts an anterior plan view of the IOL device 900, and FIG. 9C depicts a cross-sectional side view of the IOL device 900 rotated along line 9C-9C of FIG. 9B. Similarly to the IOL device 100 depicted in FIG. 3A and FIG. 3B, the embodiment depicted in FIG. 9A, FIG. 9B, and FIG. 9C comprises an anterior opening 104, a posterior opening 106, lateral openings 108, haptics 110, an anterior portion 302, and a posterior portion 304.

[0178] In some embodiments, the IOL device 900 when viewed from the perspective of FIG. 9C comprises a vertical portion 902 that extends substantially parallel to optical axis. The vertical portion 902 can be formed by the shape and / or curvature of the annular body of the device 900. The vertical portion 902 can be defined by two additional planes, including a plane corresponding to an anterior cusp 904 of the vertical portion 902, and a second plane corresponding to a posterior cusp 906 of the vertical portion 902. The width of this vertical portion can be controlled by varying the distance between the plane of the anterior cusp 904 and the plane of the posterior cusp 906. In some embodiments, the anterior cusp 902 and the posterior cusp 906 can be linked to an angled and / or curvilinear anterior portion 302 and / or posterior portion 304, respectively. In the example depicted in FIG. 9A, FIG. 9B and FIG. 9C, the vertical portion 902 may be used to retain a plurality of IOL haptics 204, or a plurality of IOL tabs 702 (such as in FIG. 7A and FIG. 7B), of an IOL.

[0179] FIG. 10A depicts an anterior oblique view of an intraocular lens (IOL) device 1000 comprising an anterior ridge, in accordance with some embodiments. FIG. 10B depicts an anterior plan view of the IOL device 1000, and FIG. 10C depicts a cross-sectional side view of the IOL device 1000 rotated along line 10C-10C of FIG. 10B. Similarly to the IOL device 100 depicted in FIG. 3A and FIG. 3B, The embodiment depicted in FIG. 10A, FIG. 10B, and FIG. 10C comprises an anterior opening 104, a posterior opening 106, haptics 110, an anterior portion 302, and a posterior portion 304.

[0180] In some embodiments, the IOL device 1000 when viewed from the perspective ofFIG. IOC comprises an annular body that is bilaterally asymmetric across the midpoint plane 306. In some embodiments, the device mays be slightly, partly, substantially, or highly asymmetric. The annular body of the IOL device 1000 as depicted in FIG. 10C comprises a partially flattened anterior portion 302 that then sharply reverts radially inward to form a trapezoidal shape. In some embodiments, the shape and size of the device of the IOL device 1000 may minimize anterior, posterior, and / or radial protrusion into the portions of the eye, such as the capsular sac, the anterior chamber of the eye, and / or the peripheral regions of the eye.

[0181] From the perspective of FIG. 10C, the plurality of lateral openings 108 are located substantially and / or completely within the posterior portion 304 of the annular body. In other embodiments, the plurality of lateral openings 108 may be located substantially or completely within the anterior portion 302, or the plurality 108 may be allocated across both the anterior portion 302 and the posterior portion 304. In further embodiments, the plurality of lateral openings may extend substantially equally into both the anterior portion 302 and the posterior portion 304.

[0182] FIG. 11A depicts an oblique anterior plan view of an intraocular lens (IOL) device 1100 containing a drug-delivery gutter 1102, in accordance with some embodiments. FIG. 11B depicts an anterior plan view of the IOL device 1100, and FIG. 11C depicts a cross-sectional side view of the IOL system 1100 rotated along line 11C-11C of FIG. 11B. Similarly to the IOL device 100 depicted in FIG. 3A and FIG. 3B, the embodiment depicted in FIG. 11 A, FIG. 11B, and FIG. 11C comprises an anterior opening 104, a posterior opening 106, lateral openings 108, haptics 110, an anterior portion 302, and a posterior portion 304. In some embodiments, the gutter 1102 may be positioned proximate to or along the edge of the anterior opening 104. In some embodiments, the gutter 1102 may be suitable for depositing, storing, releasing, and / or delivering of pharmaceutical components, such as pharmaceutical drugs, for example, ophthalmic drugs, to the eye of a subject. In some embodiments, the gutter 1102 may further comprise fenestrations that allow for drug elution. In other embodiments, the gutter may comprise of a balloon-like flexible membrane that may exist in an inflated and / or filled state, a deflated and / or compressed state, or an in-between state.

[0183] FIG. 12 is a diagrammatic cross-sectional side view of an eye 1202 into which an IOL system 1200 has been implanted according to some embodiments. Among the many features of an eye, certain features of the eye 1202 that are identified in FIG. 12 include a cornea 1204, an anterior chamber 1206, a posterior chamber 1208, a retina 1212, a vitreouscavity 1216, and an iris 1218. Similarly to the IOL system 200 depicted in FIG. 4A and FIG. 4B, the implanted embodiment depicted in FIG. 12 comprises an anterior opening 104, a posterior opening 106, a plurality of lateral openings 108, haptics 110, an anterior portion 302, a posterior portion 304, and an IOL comprising of an IOL optic 202 and IOL haptics 204, wherein at least one IOL haptic 204, extends through a lateral opening 108. In some embodiments, the implanted IOL system 1200 is located substantially in the posterior chamber 1208. According to the embodiment depicted in FIG. 12, the implanted IOL system 1200 is further located within a capsular bag 1210. The haptics 110 are in direct contact with, such as pressed against, a portion of the sulcus 1214 within the patient’s eye 1202. The sulcus 1214 comprises at least one furrow / groove between a posterior surface of the base of the iris 1218 and an anterior surface of a ciliary body 1220. The sulcus 1214 substantially extends 360 degrees around the base of the iris 1218. The implanted IOL system 1200 is positioned such that the anterior opening 104 faces towards the cornea 1204 of the patient’s eye 1202 and the posterior opening 106 faces towards the posterior chamber 1208 of the patient’s eye 1202. The anterior opening 104, the IOL optic 202, and the posterior opening 106 are centered along the optical axis 112. According to some embodiments, the implanted IOL system 1200 occupies at least some portion of the capsular bag 1210. The proportion of space occupied by the implanted system 1200 to unoccupied space may vary depending on the needs of the patient and / or the physical condition of the capsular bag 1210, and may be controlled by varying the size and / or shape of the annular body 102 and / or haptics 110 of the IOL device of the implanted system 1200. In other embodiments, the capsular bag 1210 may substantially shrink-wrap / fit snugly around the implanted IOL system 1200.

[0184] FIG. 13A depicts a close-up, cross-sectional view of an eye implanted with an IOL system 1200 from an anterior oblique perspective. FIG. 13B depicts a close-up, cross- sectional sideview of an eye implanted with an IOL system 1200. In the embodiments depicted in FIG. 13A and FIG. 13B, the haptics 110 are configured to center and / or maintain alignment of the IOL optic 202, the anterior opening 104, and the posterior opening 106 along the optical axis 112. The haptics 110 are configured to contact or engage at least a portion of the sulcus 1214. The IOL haptics 204 are further configured to resist movement of the implanted IOL system 1200. In other embodiments, the haptics 110 may be configured to prevent and / or limit anterior, posterior, and / or rotational movements of the implanted IOL system 1200. In some embodiments, the plurality of haptics 110 may serve to absorb, dampen, and / or cushion shock impulses and / or kinetic energy. According to other embodiments, the haptics 110 may serve as struts by resisting longitudinal compressionand / or serving in tension.

[0185] As depicted by the embodiments in FIG. 13A and FIG. 13B, the plurality of haptics 110 may have a length configured to extend from the annular portion 302 of the implanted system 1200 to the sulcus 1214. According to some embodiments, the wingspan and / or pathlength of the plurality of haptics 110 may be adjustable prior to or after implantation of the IOL system 1200 in the eye, or may be adjustable prior to or after implantation of the corresponding IOL device in the eye. In some embodiments, the haptics 110 can be open-loop, closed-loop, plate-style, plate-loop, monobloc-plate style, J-loop, C- loop, modified J-loop, multi-piece, single-piece, angulated, planar, or offset. In some embodiments, the haptics 110 can be coaxial or coplanar with anterior opening 104, or positioned on a different plane than the anterior opening 104.

[0186] In the embodiment depicted by FIG. 13B, the haptics 110 comprise curves that are substantially planar (i.e., two-dimensional). In other embodiments, the haptics 110 may contain a twist or are otherwise shaped such that they are nonplanar (i.e., three-dimensional). In the embodiment depicted by FIG. 13B, the haptics 110 emerge from the annular body 102 substantially tangentially to the surface of the annular body. In other embodiments, the angles at which the haptics 110 emerge from the annular body 102 may be discontinuous with the planes tangent to their points of origin. In some embodiments, a portion of the annular body 102 of the implanted IOL system 1200 may engage against an interior region or a substantially equatorial region of the capsular bag 1210, as depicted from the perspective of FIG. 13B. In some embodiments, the annular body 102 of the implanted IOL system 1200 may expand within the capsular bag 1210 in a substantially circular shape the mimics the natural and / or original anatomic shape of the capsular bag 1210. In some embodiments, the annular body 102 of the implanted IOL system 1200 may maintain the capsular bag 1210 in an expanded condition so as to fully separate the anterior opening 104 from the posterior opening 106. In some embodiments, the implanted IOL system 1200 may be configured to be self-centering within the capsular bag 1210 as it is nestled within the equatorial region during a surgical implantation procedure. In some embodiments, the self-retaining and / or retractor-like nature of the implanted system 1200, as provided by the shape and contour of the haptics 110 and / or annular body 102, may eliminate the need for suturing or holding of the system 1200. In some embodiments, the haptics 110 may additionally aid in centering the IOL, contained in the IOL system 1200, within the capsular bag 1210.

[0187] FIG. 14A depicts an anterior plan view of an intraocular lens (IOL) system 200. Similarly to the IOL device 100 depicted in FIG. 3A, in this embodiment, the IOL system200 comprises of a plurality of haptics 110 comprise of two diametrically-opposed haptics extending with radial symmetry from the anterior portion of the annular body 302, beginning substantially parallel to each other before continuing in a parabolic curve. As depicted in the embodiment of FIG. 14A, a dashed line 1402A spans the distance between the regions of peak convexity of each haptic 110. In some embodiments, such as depicted in FIG. 14A, the regions of peak convexity substantially correspond to the points of maximum curvature along the parabolic curves of the haptics 110, respectively. In some embodiments, such as depicted in FIG. 14A, the haptics 110 are in an uncompressed state, which enables a maximum distance between the opposite regions of peak convexity, or wingspan. In some embodiments, the alternate interior angles formed when the points of origin are connected by a transversal line that intersects the two substantially parallel haptics 110 may comprise any angle from 0 to 180 degrees. In some embodiments, such as depicted in FIG. 14A, the transversal line connecting the points of origin is roughly perpendicular with the orientation of the haptics 110. In some embodiments where there are two rotationally symmetric haptics are oriented to be substantially diametric about the optical axis 112, each point of origin may travel an equal arclength in the same direction along any fixed latitude while the haptics are kept substantially parallel to each other.

[0188] FIG. 14B depicts an anterior plan view of an implanted intraocular lens (IOL) system 1200. In an implanted state within the eye of a patent, the haptics 110 may undergo compression against the sulcus 1214 of the eye in order to accommodate for the reduction in available lateral space. In some embodiments, such as depicted in FIG. 14B, this results in a reduced wingspan 1402B of the haptics 110. In some embodiments, implantation may also cause the haptics 110 to deform either plastically or elastically depending on the material composition of the haptics 110 and load applied to the haptics 110. This deformation may result in a spontaneous adjustment in the curvature of the haptics 110, either throughout the entire haptic 110 or localized to a particular region. The regions of peak convexity may similarly shift or disappear.

[0189] FIG. 15 depicts an anterior plan view of an intraocular lens (IOL) device 1500 with elongated haptics 110A, in accordance with some embodiments. Similarly to the IOL device 100 depicted in FIG. 3A, the embodiment depicted in FIG. 15 comprises at least an anterior opening 104, a posterior opening 106, an anterior portion 302, and a posterior portion 304 (not visible). In some embodiments, the plurality of haptics 110, such as the elongated haptics 110A, may interface with a substantial proportion of the circumference of the sulcus 1214 of the eye. In some embodiments, the variations in the size, contour, length, number,and / or orientation of the haptics 110 may facilitate proper orientation and / or proper alignment of the implanted IOL system 1200, thereby providing correct orientation, correct placement, and / or a secure fit of the IOL optic 202 within the IOL device 100. The embodiment shown in FIG. 15 is without lateral openings, but in other embodiments, elongated haptics are included with devices having the lateral openings as disclosed herein.

[0190] FIG. 16A and FIG. 16B depict anterior plan views of intraocular lens (IOL) devices with variations in the number of haptics 110 extending from the anterior portion 302, in accordance with some embodiments. FIG. 16A shows an embodiment of the IOL device 1600, similar to the IOL device 100 depicted in FIG. 3A, but now having three haptics 110 arranged in a trigonal planar configuration around the anterior opening 104. FIG. 16B shows an embodiment of the IOL device 1600, similar to the IOL device 100 depicted in FIG. 3A, but now having four haptics 110 arranged substantially perpendicularly to each other around the anterior opening 104. The mirror images of these embodiments are also contemplated. Other embodiments may have chiral symmetry, reflective symmetry, or neither. The embodiments shown in FIG. 16A and FIG. 16B are without lateral openings, but in other embodiments, variations in the numbers of haptics are included with devices having the lateral openings as disclosed herein.

[0191] FIG. 17 depicts an anterior plan view of an intraocular lens (IOL) device 1700 with four petal-shaped haptics HOB, in accordance with some embodiments. Similarly to the IOL device 100 depicted in FIG. 3A, the embodiment depicted in FIG. 17 comprises at least an anterior opening 104, a posterior opening 106, an anterior portion 302, and a posterior portion 304 (not visible). In some embodiments, the petal-shaped haptics HOB form a ringlike shape such that it forms a continuous loop or band of material, with both ends of each haptic HOB extending from (or into) the anterior portion 302. The embodiment shown in FIG. 17 is without lateral openings, but in other embodiments, petal-shaped haptics are included with devices having the lateral openings as disclosed herein.

[0192] FIG. 18 depicts an anterior plan view of an intraocular lens (IOL) device 1800 with haptics HOC containing eyelets 1802, in accordance with some embodiments. Similarly to the IOL device 100 depicted in FIG. 3A, the embodiment depicted in FIG. 18 comprises at least an anterior opening 104, a posterior opening 106, an anterior portion 302, and a posterior portion 304 (not visible). In some embodiments, when the capsular bag is unavailable, the haptics HOC may enable an alternative method of implantation by containing eyelets 1802 with which to suture the implanted IOL system 1200 to the eye. The HOC haptics may further comprise a biting element towards their terminal ends to improvefixation of the haptics HOC within the eye. The biting element can include a grooved edge and / or an eyelet or hole 1802. For example, the grooved edge and / or eyelet or hole may be sufficient for allowing a 10-0 proline or vortex suture to pass through it. According to some embodiments, the biting element may comprise of a hanging element and / or T-shape which can be extravasated from the sclera. The embodiment shown in FIG. 18 is without lateral openings, but in other embodiments, haptics containing eyelets are included with devices having the lateral openings as disclosed herein.

[0193] FIG. 19 depicts an anterior plan view of an intraocular lens (IOL) device 1900 with haptics HOD containing attachment points 1902, in accordance with some embodiments. Similarly to the IOL device 100 depicted in FIG. 3A, the embodiment depicted in FIG. 19 comprises at least an anterior opening 104, a posterior opening 106, an anterior portion 302, and a posterior portion 304 (not visible). In some embodiments, when the capsular bag is unavailable, the haptics HOD may enable an alternative method of implantation by containing attachment points 1902 comprising a pair of nodules and / or flanges that form grooves around the circumference of the haptic. In some embodiments, anchor threads with looped ends may be positioned and / or located within the grooves of the attachment points 1902 to form a secure connection, and then pulled through the eye in order to externalize haptics HOD. In some embodiments, the attachment points 1902 may be located further towards the terminal ends of the haptics HOD to improve fixation to the anchor threads. According to some embodiments, the attachment points may further comprise of a biting element, hanging element, and / or T-shape. The embodiment shown in FIG. 19 comprises lateral openings, but in other embodiments, haptics containing attachment points are included with devices excluding the lateral openings as disclosed herein.

[0194] FIG. 20A and FIG. 20B depict a de-roofed needle 2000 comprising de-roofed portions 2002 and needlepoints 2004. In some embodiments, de-roofed needle 2000 may comprise of a needle shaft with the de-roofed portion 2002 comprising a longitudinal and / or rectilinear portion removed from its wall, creating a groove, canoe, dugout, and / or cutaway that exposes the internal lumen / borehole of the needle. The length of this de-roofed portion 2002 is at least long enough to span the diameter of the anterior chamber and / or a transconjunctival bridge formed by the de-roofed needle 2000 following implantation within the eye of a patient. The de-roofed portion 2002 may terminate before reaching the end of the needle as depicted in FIG. 20A, or extend throughout the entire length of the needle as depicted in FIG. 20B. The lumen may be sufficient for allowing a thread, such as a PMMA thread, to pass through the de-roofed needle 2000. In some embodiments, the de-roofedneedle 2000 may be classified as a thin-walled and / or ultrathin needle, such as a 30- or 27- gauge needle. In some embodiments, the needlepoint 2004 may have, a taper, a blunt taper, a cutting edge, a reverse cutting edge, a beveled edge, a curved edge, or a spatula-edge. The lumen and / or de-roofed portion 2002 may continue through the needlepoint 2002 or not. In some embodiments, the cross-sectional shape of the de-roofed needle 2000 may form a circle, an ellipse, an isosceles triangle, an equilateral triangle, a scalene triangle, a trapezoid, a quadrilateral, a crescent, a horseshoe, a semi-circle, a minor sector of a circle, a major sector of a circle, a minor segment of a circle, or a major segment of a circle. In some embodiments, the cross-sectional diameter, shape, and / or area of the de-roofed needle 2000 may vary continuously throughout the length of the needle, change abruptly, or a combination of both.

[0195] FIG. 21 depicts a close-up, cross-sectional view of an eye 2100 implanted with the de-roofed needle 2000 from an anterior oblique perspective. In some embodiments, when the capsular bag is unavailable, transconjunctival scleral fixation of an IOL device may be performed. In some embodiments, transconjunctival scleral fixation of the IOL device may be performed without involving the use of glue or sutures. In some embodiments, two transconjunctival sclerotomies may be performed using the de-roofed needle 2000 to enter the conjunctiva at an entry point 2102, traverse the anterior chamber 1206 through the center of the cornea, and exit through the conjunctiva at an exit point 2104, thereby forming an internalized bridge across the anterior chamber 1206 and piercing and / or tunneling through the sclera 2106 at either end. In some embodiments, the entry point 2102 and / or exit point 2104 may be located above or below the base of the iris 1218. The length of the de-roofed portion 2002 is sufficient to allow for the de-roofed portion 2002 to extend from the surface of the sclera 2106 at either end. In some embodiments, an anterior chamber maintainer may be used to support the eye during the method. Paracentesis wounds to the conjunctiva may be made to facilitate intraocular maneuvering within the anterior chamber.

[0196] FIG. 22 depicts an anterior plan view of an eye 2200 implanted with the deroofed needle 2000 that has been threaded with anchor threads 2202. Following placement of the de-roofed needle 2000 within the eye, the ends of two opposing anchor threads 2202 may then be passed ab-interno into the anterior chamber at the entry point 2102 and the exit point 2104 via the tunnels through the sclera 2106 created by the exposed lumen of the de-roofed portion 2002 of the de-roofed needle 2000. In some embodiments, as the anchor threads 2202 are pushed they are guided by the channel formed by the lumen of the de-roofed needle 2000 and moved towards the center of the anterior chamber, remaining visible within the de-roofed portion 2002. In some embodiments, the de-roofed needle 2000 is extracted via pulling orpushing out of the eye. In some embodiments, the ends of the two threads may comprise loops. Note that the de-roofed needle 2000 need not necessarily pass through the center of the anterior chamber 1206, but can connect any two endpoints that lie along the limbus 2206 of the eye.

[0197] FIG. 23 depicts an anterior plan view of an eye 2300 implanted with an intraocular lens (IOL) device 1900 with haptics HOD containing attachment points 1902, in accordance with some embodiments. In some embodiments, following insertion of the deroofed needle 2000 and implantation of the IOL device 1900 within the anterior chamber 1206, two diametrically opposed haptics HOD of the plurality of haptics of the IOL device 1900 are then threaded into either loop 2204 of the anchor threads 2202. In some embodiments, the looped ends 2204 may be positioned and / or located within the grooves of the attachment points 1902 to form a secure connection, and then pulled through the eye in order to externalize haptics HOD. In some embodiments, the haptics HOD may be laced and / or threaded along the exposed channel and / or lumen of the de-roofed portion 2002 of the needle directly from within the anterior chamber. In some embodiments, the haptics HOD may be externalized by pulling and / or pushing each haptic HOD and / or attached anchor thread 2202 out of the anterior chamber 1206 and through the small scleral tunnels created by the two transconjunctival sclerotomies, exiting from the original entry point 2102 and exit point 2104. In some embodiments, the de-roofed needle 2000 remains implanted throughout the extemalization process, such that the haptics HOD and / or attached anchor threads 2202 are pulled along and then out of the externally exposed de-roofed portion 2002 of the needle. In some embodiments, intraocular forceps may be used to manipulate the positioning of the haptics HOD and / or anchor threads 2202, or used to reorient and / or rotate the implanted IOL device 1900.

[0198] FIG. 24 depicts an anterior plan view of an eye 2400 implanted with an intraocular lens (IOL) device 1900 with haptics HOD that have been externalized and fastened with fasteners 2404, in accordance with some embodiments. In some embodiments, following extemalization of the haptics HOD, the tips and / or terminal ends of the haptics HOD are melted using disposable cautery to form a mushroom tip and / or button-like configuration. In some embodiments, attached anchor threads 2202 may first be disconnected and / or severed from the externalized haptics HOD. In some embodiments, the externalized haptics HOD may be further shortened and / or trimmed, which may result in the removal of attachment points 1902, as desired. In some embodiments, pushing the ends of the externalized haptics into the sclera 2106 may cause the IOL device 1900 to be pushedtowards the center of the anterior chamber 1206, thereby achieving centration and / or stability of the IOL device 1900. In some embodiments, the ends of the haptics HOD may comprise teeth that engage with a fastener 2404 comprising an external pawl and / or latch that abuts the outer surface of the sclera 2106 at the entry point 2102 and exit point 2104, whereby the haptics HOD become fastened via a ratcheting mechanism.

[0199] FIG. 26A depicts an anterior oblique views of the IOL device 2600, in accordance with some embodiments. The IOL device 2600 comprises an intraocular ring 2601 centered along an optical axis 112, further comprising a plurality of loops 2602 that are attached to and / or extend from the intraocular ring 2601. Each loop 2602 is positioned such that it is suitable for and may receive a haptic of an IOL upon insertion of an IOL into the IOL device 2600. In the embodiment depicted in FIG. 26A, each loop 2602 is an elliptically-shaped loop oriented substantially perpendicular to the intraocular ring 2601 and facing radially outward from the optical axis 112. According to some embodiments, the loops 2602 being substantially 90 degrees apart from each other helps rotate and align toric IOLS. In the embodiment of FIG. 26A, the loops are positioned below the intraocular ring 2601 such that the loops 2602 extend towards the posteriorly-facing side of the intraocular ring 2601. The IOL device 2600 further comprises a plurality of haptics 110, such as the two haptics 110 depicted in FIG. 26A, which are attached to and / or extend from the intraocular ring 2601. In some embodiments, each of the plurality of haptics 110, including each of their respective points of origination from the intraocular ring 2601, have a smooth surface. In the embodiment depicted in FIG. 26A, the plurality of haptics 110 is two diametrically-opposed haptics 110 that are rotationally symmetric with each other. In some embodiments, the intraocular ring 2601 of the IOL device 2600 has a smooth and / or continuous surface, as depicted in FIG. 26A.

[0200] FIG. 26B depicts an anterior oblique view of the intraocular lens (IOL) system, in accordance with some embodiments. The IOL system comprises a complex of the IOL device 2600 and an intraocular lens (IOL). As depicted in FIG. 26B, the IOL comprises an IOL optic 202 and a plurality of IOL haptics 204. The IOL optic 202 is closely secured to the intraocular ring 2601. In the embodiment of FIG. 26B, the IOL is positioned below the intraocular ring 2601. In some embodiments, such as depicted in FIG. 26B, the IOL optic 202 is smaller than the intraocular ring 2601. In some embodiments, the IOL device 2600 may also accommodate an IOL having an IOL optic 202 that is substantially the same size as the intraocular ring 2601, depending on the ophthalmic needs of the patient. The IOL haptics 204 extend from the edge of the IOL optic 202 and through the loops 2602. The dimensionsof the loops 2602 are sufficient to at least restrict the movement of the IOL haptics 204 within the IOL device 2600. With the IOL haptics 204 extended through the loops 2602, the IOL optic 202 is centered along the optical axis 112 and the IOL is secured so as not to rotate freely within the device 2600 or become dislodged. According to some embodiments, the IOL is held within a certain distance from the intraocular ring 2601 such that a gap 2603 is substantially maintained between the IOL optic 202 and the intraocular ring 2601. In some embodiments, the intraocular ring 2601 of the IOL device 2600 has a smooth and / or continuous surface.

[0201] FIG. 26C depicts an anterior plan view of the IOL system detailed in FIG. 26B, which comprises of an IOL optic 202 and the IOL device 2600. In some embodiments, such as depicted in FIG. 26C, an IOL haptic 204 extends through a loop 2602, which secures the IOL within the IOL device 2600. In some embodiments, such as depicted in FIG. 26C, each IOL haptic 204, such as the two diametrically-opposed IOL haptics 204 that are rotationally symmetric with each other, extend through two opposing loops 2602, which secures the IOL within the IOL device 2600. In some embodiments, such as depicted in FIG. 26C, the device haptics 110 and the IOL haptics 204 are oriented perpendicularly to each other. In some embodiments, the device haptics 110 and the IOL haptics 204 may be oriented in different arrangements. In some embodiments, the IOL haptics 204 extend from the edge of the IOL optic 202 and through the loops 2602. In some embodiments, the dimensions of the loops 2602 are sufficient to restrict the movement of the IOL haptics 204 within the IOL device 2600. In some embodiments, with the IOL haptics 204 extended through the loops 2602, the IOL optic 202 is centered along the optical axis 112 and the IOL is secured so as not to rotate freely within the device 100 or become dislodged. In some embodiments, the size and / or shape of the gap 2603 may be modulated so as to partially occlude or obstruct light from passing through the gap 2603.

[0202] FIG. 26D depicts a cross-sectional side view of the IOL system rotated along line 26D-26D of FIG. 26C. In some embodiments, such as depicted in the embodiment of FIG. 26D, the IOL optic 202 is located substantially just beneath the intraocular ring 2601. However, in some embodiments, the IOL optic 202 may substantially be secured along a midpoint plane of the plurality of loops 2602, or may rest along a bottom and / or posterior portion of at least one loop 2602. In other embodiments, the loops 2602 and the IOL optic 202 may be positioned above the intraocular ring 2601, or the intraocular ring may correspond substantially with a midpoint of one or more of the plurality of loops 2602. In some embodiments, such as depicted in FIG. 26D, the IOL optic 202 is located substantiallyor completely within an anterior portion of the IOL device 2600. In other embodiments, the IOL optic may be substantially or completely within a posterior portion of the IOL device 2600, or extend substantially equally into both the anterior portion and the posterior portion. In some the embodiments, such as depicted in FIG. 26D, the IOL optic 202 has a diameter that is substantially equal to or smaller than the intraocular ring 2601, such that a gap 2603 is present between the IOL optic 202 and the interocular ring 2601, depending on the ophthalmic needs of the patient. In some the embodiments, such as depicted in FIG. 26D, the IOL comprises of a uniform thickness across both the IOL optic 202 and the IOL haptics 204. In some embodiments, such as depicted in FIG. 26D, the thickness of the IOL occupies roughly a quarter of the width of the loops 2602. In some embodiments, the thickness of the IOL may vary depending upon the ophthalmic needs of the patient, while width of the loops 2602 may be constricted or expanded in order to properly accommodate a particular IOL haptic 204.

[0203] FIG. 27A depicts an anterior oblique view of an IOL device 2700 comprising an intraocular ring 2701, haptics 110, and an exterior and / or interior recess 2704. In the embodiment depicted in FIG. 27A, an exterior and interior recess 2704 is located substantially at a midpoint plane of the IOL device 2700, which may subsequently create a ridge located in an anterior portion of the intraocular ring 2701 and another ridge located in a posterior portion of the intraocular ring 2701. In some embodiments, the recess 2704 may extend completely around (e.g., continuously) the intraocular ring 2701 as depicted in FIG. 27A, or the recess 2704 may be restricted to only a portion of the intraocular ring 2701. The longitudinal and / or latitudinal dimensions and / or shape of the recess 2704 may be controlled to provide sufficient space to accommodate the IOL haptics 204. In addition, the recess 2704 may be configured to provide support or otherwise affix one or more IOLS within the IOL device. Furthermore, the embodiment of FIG. 27A depicts a plurality of nodes 2702 evenly- spaced along the anterior portion of the intraocular ring 2701, which are suitable for designating the position within the recess 2704 to divide further for accepting a haptic from an IOL (see FIG. 27B). In some embodiments, the nodes 2702 may potentially be positioned as-desired anywhere along the circumference of the intraocular ring 2701, including in the anterior portion, posterior portion, and / or an intermediate portion of the intraocular ring 2701.

[0204] FIG. 27B depicts an anterior oblique view of an IOL system comprising a complex of the IOL device 2700 and an intraocular lens (IOL). In the embodiment of FIG. 27B, the recess 2704 may create a line of weakness along the circumference of the intraocular ring 2701, such that the intraocular ring 2701 is separable along the line of weakness to formone or more loops, bubbles, and / or open portions 2705 of a size sufficient to accommodate an IOL haptic 204. In the embodiment depicted in FIG. 27A, the IOL haptics 204 may be configured such that each IOL haptic 204 can slide and / or be pulled through open portions 2705 and / or between anterior and / or posterior ridges. In other embodiments, the recess 2704 may be configured such that the intraocular ring 2701 can be forcibly pulled apart, or configured such that the use of a scalpel or cutting instrument is required to separate the intraocular ring 2701 along the recess. In some embodiments, one or more nodes 2702 may be configured to demarcate a boundary point of the recess 2704 along a circumference of the intraocular ring 2701, including the position of one or more open portions 2705. In the embodiment depicted in FIG. 27B, the IOL is positioned co-planar with the intraocular ring 2701. In some embodiments, such as depicted in FIG. 27B, the IOL optic 202 is smaller than the intraocular ring 2701. In some embodiments, the IOL device 2700 may also accommodate an IOL having an IOL optic 202 that is substantially the same size as the intraocular ring 2601, depending on the ophthalmic needs of the patient. The IOL haptics 204 extend from the edge of the IOL optic 202 and through the open portions 2705. The dimensions of the open portions 2705 are sufficient to at least restrict the movement of the IOL haptics 204 within the IOL device 2700. With the IOL haptics 204 extended through the open portions 2705, the IOL optic 202 is centered along the optical axis 112 and the IOL is secured so as not to rotate freely within the device 2700 or become dislodged. According to some embodiments, the IOL is held within a certain distance from the intraocular ring 2701 such that a gap 2703 is substantially maintained between the IOL optic 202 and the intraocular ring 2701.

[0205] FIG. 27C depicts an anterior plan view of the IOL system detailed in FIG. 27B, which comprises of an IOL optic 202 and the IOL device 2700. In some embodiments, such as depicted in FIG. 27C, an IOL haptic 204 extends through an open portion 2705 of the recess 2702, which secures the IOL within the IOL device 2700. In some embodiments, such as depicted in FIG. 27C, each IOL haptic 204, such as the two diametrically-opposed IOL haptics 204 that are rotationally symmetric with each other, extend through two open portions 2705 that have been opened opposite each other along the intraocular ring 2702, which secures the IOL within the IOL device 2700. In some embodiments, such as depicted in FIG. 27C, the device haptics 110 and the IOL haptics 204 are oriented perpendicularly to each other. In some embodiments, the device haptics 110 and the IOL haptics 204 may be oriented in different arrangements. In some embodiments, the IOL haptics 204 extend from the edge of the IOL optic 202 and through the open portions 2705. In some embodiments,the dimensions of the open portions 2705 are sufficient to restrict the movement of the IOL haptics 204 within the IOL device 2700. In some embodiments, with the IOL haptics 204 extended through the open portions 2705, the IOL optic 202 is centered along the optical axis 112 and the IOL is secured so as not to rotate freely within the device 100 or become dislodged. In some embodiments, the size and / or shape of the gap 2703 may be modulated so as to partially occlude or obstruct light from passing through the gap 2703.

[0206] FIG. 27D depicts a cross-sectional side view of the IOL system rotated along line 27D-27D of FIG. 27C. In some embodiments, such as depicted in the embodiment of FIG. 27D, the IOL optic 202 is located substantially just beneath the intraocular ring 2701. In some embodiments, such as depicted in the embodiment of FIG. 27D, the IOL optic 202 is substantially secured along a midpoint plane of the intraocular ring 2701, which has been partially split laterally to form open portions 2705. In some embodiments, the open portions 2705 and the IOL optic 202 do not coincide with the outermost perimeter of the intraocular ring 2701. In other embodiments, the open portions 2705 and the IOL optic 202 may be positioned towards an anterior or posterior portion of the intraocular ring 2701. According to some embodiments, the open portions 2705 may potentially be created and / or positioned as- desired anywhere along the circumference of the recess 2704, including in the anterior portion, posterior portion, and / or an intermediate portion of the intraocular ring 2701. Alternatively and / or additionally, the formation of the open portions 2705 may be restricted by the placement of one or more nodes 2702. In some the embodiments, the IOL optic 202 has a diameter that is substantially equal to or smaller than the intraocular ring 2701, depending on the ophthalmic needs of the patient. In some the embodiments, such as depicted in FIG. 27D, the IOL comprises of a uniform thickness across both the IOL optic 202 and the IOL haptics 204. In some embodiments, such as depicted in FIG. 27D, the thickness of the IOL occupies roughly a full width of the open portion 2705. In some embodiments, the thickness of the IOL may vary depending upon the ophthalmic needs of the patient, while width of the open portions 2705 may be constricted or expanded in order to properly accommodate a particular IOL haptic 204.

[0207] FIG. 27E depicts a close-up view of a segment of an intraocular ring 2701 from an anterior oblique perspective. In the embodiment of FIG. 27E depicts a pair of adjacent nodes 2702, which are positioned alongside a portion of the recess 2704.

[0208] FIG. 28A depicts an anterior oblique view of an IOL device 2800 comprising an intraocular ring 2801, haptics 110, and a plurality of perforations 2804. In the embodiment depicted in FIG. 28A, the perforations 2804 are located substantially at a midpoint plane ofthe IOL device 2800, which may subsequently create a first section comprising an anterior portion of the intraocular ring 2801 and a second section comprising a posterior portion of the intraocular ring 2801. In some embodiments, a series of perforations 2804 may extend completely around (e.g., continuously) the intraocular ring 2801 as depicted in FIG. 28A, or the perforations 2804 may be restricted to only a portion of the intraocular ring 2801. The longitudinal and / or latitudinal dimensions and / or shape of the a line and / or region of perforations 2804 may be controlled to provide sufficient space to accommodate the IOL haptics 204. For example, the perforations 2804 may be configured to create a detachable and / or knock-out region along the wall of the intraocular ring 2801. Alternatively and / or additionally, a series of perforations may be configured into a variety of different patterns, such as zigzag, curved, wavy, cross-hatched, diagonal, intersecting, parallel, squiggly, concentric, scalloped, staggered, diverging, converging, and / or a combination thereof. In addition, the size of each individual perforation 2804 may vary. Furthermore, the embodiment of FIG. 28A depicts a plurality of nodes 2802 evenly-spaced along the anterior portion of the intraocular ring 2801, which are suitable for designating the position among the perforations 2804 to begin tearing and / or separating so as to reconfigure the intraocular ring 2801 to accept a haptic from an IOL (see FIG. 28B). In some embodiments, the nodes 2802 may potentially be positioned as-desired anywhere along the circumference of the intraocular ring 2801, including in the anterior portion, posterior portion, and / or an intermediate portion of the intraocular ring 2801.

[0209] FIG. 28B depicts an anterior oblique view of an IOL system comprising a complex of the IOL device 2800 and an intraocular lens (IOL). In the embodiment of FIG. 28B, the perforations 2804 may create a line of weakness along the circumference of the intraocular ring 2801, such that the intraocular ring 2801 is separable along the line of weakness to form one or more loops, bubbles, and / or open portions 2805 of a size sufficient to accommodate an IOL haptic 204. In the embodiment depicted in FIG. 28A, the IOL haptics 204 may be configured such that each IOL haptic 204 can slide and / or be pulled through open portions 2805 and / or between anterior and / or posterior sections. In other embodiments, the perforations 2804 may be configured such that the intraocular ring 2801 can be forcibly pulled and / or tom apart, or configured such that the use of a scalpel or cutting instrument is required to separate the intraocular ring 2801 along the recess. In some embodiments, one or more nodes 2802 may be configured to demarcate a boundary point of the recess 2804 along a circumference of the intraocular ring 2801, including the position of one or more preconfigured open portions 2805. In the embodiment depicted in FIG. 28B, theIOL is positioned co-planar with the intraocular ring 2801. In some embodiments, such as depicted in FIG. 28B, the IOL optic 202 is smaller than the intraocular ring 2801. In some embodiments, the IOL device 2800 may also accommodate an IOL having an IOL optic 202 that is substantially the same size as the intraocular ring 2801, depending on the ophthalmic needs of the patient. The IOL haptics 204 extend from the edge of the IOL optic 202 and through the open portions 2805. The dimensions of the open portions 2805 are sufficient to at least restrict the movement of the IOL haptics 204 within the IOL device 2800. With the IOL haptics 204 extended through the open portions 2805, the IOL optic 202 is centered along the optical axis 112 and the IOL is secured so as not to rotate freely within the device 2800 or become dislodged. According to some embodiments, the IOL is held within a certain distance from the intraocular ring 2801 such that a gap 2803 is substantially maintained between the IOL optic 202 and the intraocular ring 2801.

[0210] FIG. 29A depicts an anterior oblique view of an IOL device 2900 comprising an intraocular ring 2901, haptics 110, and a plurality of slits 2904. In the embodiment depicted in FIG. 29A, the slits 2904 are located substantially at a midpoint plane of the IOL device 2900, which may subsequently create a first section comprising an anterior portion of the intraocular ring 2901 and a second section comprising a posterior portion of the intraocular ring 2901. In some embodiments, a series of slits 2904 may extend completely around (e.g., continuously) the intraocular ring 2901 as depicted in FIG. 29A, or the slits 2904 may be restricted to only a portion of the intraocular ring 2901. The longitudinal and / or latitudinal dimensions and / or shape of the a line and / or area of slits 2904 may be controlled to provide sufficient space to accommodate the IOL haptics 204. For example, the slits 2904 may be configured to create a detachable and / or knock-out region along the wall of the intraocular ring 2901. Alternatively and / or additionally, a series of slits may be configured into a variety of different patterns, such as zigzag, curved, wavy, cross-hatched, diagonal, intersecting, parallel, squiggly, concentric, scalloped, staggered, diverging, converging, and / or a combination thereof. In addition, the size of each individual slit 2904 may vary.Furthermore, the embodiment of FIG. 29A depicts a plurality of nodes 2902 evenly-spaced along the anterior portion of the intraocular ring 2901, which are suitable for designating the position among the slits 2904 to begin tearing and / or separating so as to reconfigure the intraocular ring 2901 to accept a haptic from an IOL (see FIG. 29B). In some embodiments, the nodes 2902 may potentially be positioned as-desired anywhere along the circumference of the intraocular ring 2901, including in the anterior portion, posterior portion, and / or an intermediate portion of the intraocular ring 2901.

[0211] FIG. 29B depicts an anterior oblique view of an IOL system comprising a complex of the IOL device 2900 and an intraocular lens (IOL). In the embodiment of FIG. 29B, the slits 2904 may create a line of weakness along the circumference of the intraocular ring 2901, such that the intraocular ring 2901 is separable along the line of weakness to form one or more loops, bubbles, and / or open portions 2905 of a size sufficient to accommodate an IOL haptic 204. In the embodiment depicted in FIG. 29A, the IOL haptics 204 may be configured such that each IOL haptic 204 can slide and / or be pulled through open portions 2905 and / or between anterior and / or posterior sections. In other embodiments, the slits 2904 may be configured such that the intraocular ring 2901 can be forcibly pulled and / or torn apart, or configured such that the use of a scalpel or cutting instrument is required to separate the intraocular ring 2901 along the recess. In some embodiments, one or more nodes 2902 may be configured to demarcate a boundary point of the recess 2904 along a circumference of the intraocular ring 2901, including the position of one or more preconfigured open portions 2905. In the embodiment depicted in FIG. 29B, the IOL is positioned co-planar with the intraocular ring 2901. In some embodiments, such as depicted in FIG. 29B, the IOL optic 202 is smaller than the intraocular ring 2901. In some embodiments, the IOL device 2900 may also accommodate an IOL having an IOL optic 202 that is substantially the same size as the intraocular ring 2901, depending on the ophthalmic needs of the patient. The IOL haptics 204 extend from the edge of the IOL optic 202 and through the open portions 2905. The dimensions of the open portions 2905 are sufficient to at least restrict the movement of the IOL haptics 204 within the IOL device 2900. With the IOL haptics 204 extended through the open portions 2905, the IOL optic 202 is centered along the optical axis 112 and the IOL is secured so as not to rotate freely within the device 2900 or become dislodged. According to some embodiments, the IOL is held within a certain distance from the intraocular ring 2901 such that a gap 2903 is substantially maintained between the IOL optic 202 and the intraocular ring 2901.

[0212] The embodiments described herein are intended to be merely exemplary, and those skilled in the art will recognize, or are able to ascertain using no more than routine experimentation, numerous equivalents of specific compounds, materials, and procedures. All such equivalents are considered to be within the scope of the invention and are encompassed by the appended claims.6. EXEMPLARY EMBODIMENTS

[0213] One or more than one (including for instance all) of the following exemplaryEmbodiments may comprise each of the other embodiments or parts thereof.

[0214] 1 A. An intraocular lens device, comprising: i) an annular body comprising: a) an anterior portion comprising an anterior opening radially centered along an optical axis; and b) a posterior portion comprising a posterior opening radially centered along the optical axis; wherein the anterior portion and the posterior portion meet at a plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening; and ii) a plurality of haptics attached to the anterior portion.

[0215] 2A. An intraocular lens device, comprising: i) an annular body portion: a) an anterior portion comprising an anterior opening radially centered along an optical axis; b) a posterior portion comprising a posterior opening radially centered along the optical axis; and c) a lateral portion interposed between the anterior portion and the posterior portion, wherein the lateral portion protrudes radially beyond the anterior portion and the posterior portion; and ii) a plurality of haptics extending from the anterior portion of the annular body.

[0216] 3 A. An intraocular lens device, comprising: i) an annular body portion: a) an anterior opening radially centered along an optical axis; b) a posterior opening radially centered along an optical axis; and c) a lateral portion extending from the anterior opening to the posterior opening, wherein the lateral portion protrudes radially beyond the anterior opening and the posterior opening; and ii) a plurality of haptics extending from an anterior portion of the lateral portion of the annular body.

[0217] 4A. An intraocular lens device, comprising: i) an annular body portion comprising an anterior portion comprising an anterior opening, a posterior portion comprising a posterior opening, and a lateral portion interposed between the anterior portion and the posterior portion; andii) a plurality of haptics extending from the anterior portion of the annular body; wherein: a) the anterior opening and the posterior opening are radially centered along an optical axis, b) the anterior opening is larger than the posterior opening, and c) the lateral portion comprises a plurality of lateral openings perpendicular to the optical axis.

[0218] 5 A. The intraocular lens device of any one of Embodiments 1 A-4A, wherein the device is configured to be inserted in a capsular bag of an eye; optionally the device comprises an anti-lens epithelial cell proliferation coating and / or is made of a material which allows removal of proliferating cells.

[0219] 6 A. The intraocular lens device of any one of Embodiments 1 A-5A, wherein the device is configured to be inserted in a capsular bag of an eye after removal of a lens.

[0220] 7 A. The intraocular lens device of any one of Embodiments 1 A-6A, wherein the device is sized and shaped for implantation into a capsular bag of an eye.

[0221] 8 A. The intraocular lens device of any one of Embodiments 1 A-4A, wherein the device is configured to be inserted in an eye lacking a capsular bag.

[0222] 9 A. The intraocular lens device of any one of Embodiments 1 A-8A, wherein the device is sized and scaled to accommodate a size of an eye.

[0223] 10 A. The intraocular lens device of any one of Embodiments 1 A-9A, wherein the device is a single-molded design.

[0224] 11 A. The intraocular lens device of any one of Embodiments 1 A-10A, wherein the device is molded from a single piece of material.

[0225] 12 A. The intraocular lens device of any one of Embodiments 1 A-l 1 A, wherein the device is flexible; optionally wherein the device is flexible enough to be loaded into a cartridge for implantation.

[0226] 13A. The intraocular lens device of any one of Embodiments 1 A-12A, wherein the device is collapsible, compressible and / or foldable; optionally wherein the device is collapsible, compressible and / or foldable enough to be loaded into a cartridge for implantation.

[0227] 14A. The intraocular lens device of any one of Embodiments 1 A-13A, wherein the device is collapsible, compressible and / or foldable; optionally wherein the device is collapsible, compressible and / or foldable enough to be injectable by a needle with a width of about 2.4 mm.

[0228] 15 A. The intraocular lens device of any one of Embodiments 1A-14A, wherein the device is deformable for insertion into a capsular bag of an eye; optionally wherein the device is deformable enough to be loaded into a cartridge for implantation.

[0229] 16 A. The intraocular lens device of any one of Embodiments 1A-15A, wherein the device is self-expandable upon insertion into a capsular bag of an eye.

[0230] 17 A. The intraocular lens device of any one of Embodiments 1 A-16A, wherein the device is a prosthetic capsular device.

[0231] 18 A. The intraocular lens device of any one of Embodiments 1A-17A, wherein the device comprises poly(methyl-methacrylate).

[0232] 19 A. The intraocular lens device of any one of Embodiments 1A-18A, wherein the annular body has radial symmetry.

[0233] 20 A. The intraocular lens device of any one of Embodiments 1A-18A, wherein the annular body has a ring shape.

[0234] 21 A. The intraocular lens device of any one of Embodiments 1A-18A, wherein the annular body has a substantially prolate spheroid shape.

[0235] 22 A. The intraocular lens device of any one of Embodiments 1A-18A, wherein the annular body has a substantially ellipsoidal shape.

[0236] 23 A. The intraocular lens device of any one of Embodiments 1A-18A, wherein the annular body has a substantially toroid shape.

[0237] 24 A. The intraocular lens device of any one of Embodiments 1A-18A, wherein the annular body is substantially donut-shaped or substantially tire-shaped.

[0238] 25 A. The intraocular lens device of any one of Embodiments 1 A-24A, wherein the annular body extends from the anterior opening of the anterior portion to the posterior opening of the posterior portion.

[0239] 26 A. The intraocular lens device of any one of Embodiments 1 A-25A, wherein the annular body is bilaterally symmetrical across a plane perpendicular to the optical axis.

[0240] 27 A. The intraocular lens device of any one of Embodiments 1 A-26A, wherein annular body is bilaterally symmetrical across at least one plane dividing the anterior and posterior openings.

[0241] 28 A. The intraocular lens device of any one of Embodiments 1 A-27A, wherein the annular body is bilaterally symmetrical across at least one plane parallel to the anterior and posterior openings.

[0242] 29 A. The intraocular lens device of any one of Embodiments 1 A-28A, wherein the annular body has a mesh surface.

[0243] 30 A. The intraocular lens device of any one of Embodiments 1 A-28A, wherein the annular body has a smooth surface.

[0244] 31 A. The intraocular lens device of any one of Embodiments 1A-30A, wherein the annular body has a smooth, continuous surface.

[0245] 32A. The intraocular lens device of any one of Embodiments 1A-31A, wherein the annular body has a non-porous surface.

[0246] 33A. The intraocular lens device of any one of Embodiments 1 A-32A, wherein the height of the annular body along the optical axis is in the range of between about 1.5-3.5 mm.

[0247] 34A. The intraocular lens device of Embodiment 33A, wherein the height of the annular body along the optical axis is in the range of between about 1.5-2.0 mm, about 1.5-2.5 mm, about 2.0-2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, or about 3.0-3.5 mm.

[0248] 35A. The intraocular lens device of Embodiment 33A or Embodiment 34A, wherein the height of the annular body along the optical axis is in the range of between about1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, or about 3.5 mm.

[0249] 36 A. The intraocular lens device of any one of Embodiments 1 A-35A, wherein the anterior portion has radial symmetry.

[0250] 37 A. The intraocular lens device of any one of Embodiments 1 A-36A, wherein the anterior portion is domed.

[0251] 38 A. The intraocular lens device of any one of Embodiments 1 A-37A, wherein the anterior portion is curvilinear.

[0252] 39 A. The intraocular lens device of any one of Embodiments 1 A-38A, wherein the anterior portion is arcuate.

[0253] 40 A. The intraocular lens device of any one of Embodiments 1 A-39A, wherein the anterior portion extends from the plane substantially at the midpoint of the annular body and terminates at the anterior opening.

[0254] 41 A. The intraocular lens device of any one of Embodiments 1 A-40A, wherein the anterior portion is tapered towards the anterior opening.

[0255] 42 A. The intraocular lens device of any one of Embodiments 1 A-41 A, wherein the posterior portion has radial symmetry.

[0256] 43 A. The intraocular lens device of any one of Embodiments 1 A-42A, whereinthe posterior portion is domed.

[0257] 44A. The intraocular lens device of any one of Embodiments 1 A-43A, wherein the posterior portion is curvilinear.

[0258] 45 A. The intraocular lens device of any one of Embodiments 1 A-44A, wherein the posterior portion is arcuate.

[0259] 46 A. The intraocular lens device of any one of Embodiments 1 A-45A, wherein the posterior portion extends from the plane substantially at the midpoint of the annular body and terminates at the posterior opening.

[0260] 47 A. The intraocular lens device of any one of Embodiments 1 A-46A, wherein the posterior portion is tapered towards the posterior opening.

[0261] 48 A. The intraocular lens device of any one of Embodiments 1 A-47A, wherein the annular body is symmetrical over the plane at a midpoint between the anterior portion and the posterior portion.

[0262] 49 A. The intraocular lens device of any one of Embodiments 1 A-48A, wherein the annular body is not symmetrical over the plane at a midpoint between the anterior portion and the posterior portion.

[0263] 50A. The intraocular lens device of any one of Embodiments 1 A-49A, wherein the annular body comprises a transition dividing the anterior portion and the posterior portion.

[0264] 51 A. The intraocular lens device of Embodiment 50A, wherein the transition point comprises an outermost diameter of the annular body.

[0265] 52A. The intraocular lens device of any one of Embodiments 1A-51A, wherein the annular body at the plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening comprises an outermost diameter of the annular body.

[0266] 53A. The intraocular lens device of any one of Embodiments 1 A-52A, wherein the portion of the annular body where the anterior portion and the posterior portion meet substantially at the plane at the midpoint of the annular body between the anterior opening and the posterior opening is a lateral portion.

[0267] 54A. The intraocular lens device of any one of Embodiments 1 A-53A, wherein the anterior portion extends from the lateral portion and terminates at the anterior opening.

[0268] 55 A. The intraocular lens device of any one of Embodiments 1 A-54A, wherein the posterior portion extends from the lateral portion and terminates at the posterior opening.

[0269] 56A. The intraocular lens device of any one of Embodiments 1 A-55A, whereinthe transition point comprises an outermost perimeter of the annular body.

[0270] 57A. The intraocular lens device of any one of Embodiments 51-56A, wherein the outermost diameter of the annular body spans the outermost perimeter of the annular body.

[0271] 58A. The intraocular lens device of any one of Embodiments 1 A-57A, wherein the lateral portion extends from the anterior portion to the posterior portion through a plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening.

[0272] 59A. The intraocular lens device of any one of Embodiments 1 A-58A, wherein the lateral portion comprises a plurality of lateral openings.

[0273] 60A. The intraocular lens device of any one of Embodiments 1 A-59A, wherein the lateral portion protrudes radially beyond the anterior portion and the posterior portion.

[0274] 61 A. The intraocular lens device of any one of Embodiments 1 A-60A, wherein the lateral portion comprises an outermost diameter of the annular body.

[0275] 62A. The intraocular lens device of any one of Embodiments 51A-61A, wherein the outermost diameter of the annular body is in the range of between about 5-20 mm.

[0276] 63 A. The intraocular lens device of Embodiment 62A, wherein the outermost diameter is in the range of between about 5-6 mm, about 5-7 mm, about 5-8 mm, about 5-9 mm, about 5.0-10 mm, about 6-7 mm, about 6-8 mm, about 6-9 mm, about 6-10 mm, about 7-8 mm, about 7-9 mm, about 7-10 mm, about 8-9 mm, about 8-10 mm, about 9-10 mm, about 5-10 mm, about 5-12 mm, about 6-12 mm, about 8-12 mm, about 10-12 mm, about 10- 15 mm, about 12-14 mm, about 12-15 mm, about 14-15 mm, about 5-18 mm, about 8-20 mm, about 10-20 mm, about 10-18 mm, about 12-20 mm, about 12-18 mm, or about 14-20 mm.

[0277] 64A. The intraocular lens device of Embodiment 62A or Embodiment 63 A, wherein the outermost diameter of the annular body is about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, about 16 mm, about 17 mm, about 18 mm, about 19 mm, or about 20 mm.

[0278] 65 A. The intraocular lens device of any one of Embodiments 1 A-64A, wherein the annular body comprises a curve between the anterior and posterior portionsA, wherein the curve comprises a radius in the range of between about 0.1-10 mm.

[0279] 66 A. The intraocular lens device of any one of Embodiments 1 A-65A, wherein the arcuate path of the surface along the anterior portion from the anterior opening comprises a radius in the range of between about 5.0-20 mm.

[0280] 67 A. The intraocular lens device of any one of Embodiments 1 A-66A, wherein the arcuate path of the surface along the posterior portion from the posterior opening comprises a radius in the range of between about 1.0-20 mm, optionally 5.0-20 mm.

[0281] 68 A. The intraocular lens device of any one of Embodiments 1 A-67A, wherein the annular body comprises a vertical portion between the anterior and posterior portions, wherein the vertical portion is substantially parallel to the optical axis.

[0282] 69 A. The intraocular lens device of any one of Embodiments 1 A-68A, wherein the annular body further comprises a plurality of lateral openings.

[0283] 70A. The intraocular lens device of any one of Embodiments 1 A-69A, wherein the plurality of lateral openings comprises 2-4, 2-6, or 2-8 lateral openings.

[0284] 71 A. The intraocular lens device of any one of Embodiments 1 A-69A, wherein the plurality of lateral openings comprises 2, 3, 4, 5, 6, 7, or 8 lateral openings.

[0285] 72 A. The intraocular lens device of any one of Embodiments 1 A-71 A, wherein the plurality of lateral openings comprises at least a first lateral opening substantially opposite at least a second lateral opening.

[0286] 73 A. The intraocular lens device of any one of Embodiments 1 A-72A, wherein the plurality of lateral openings comprises at least a third lateral opening substantially opposite at least a fourth lateral opening.

[0287] 74A. The intraocular lens device of any one of Embodiments 1 A-73A, wherein the plurality of lateral openings are positioned along a plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening.

[0288] 75 A. The intraocular lens device of any one of Embodiments 1 A-74A, wherein the plurality of lateral openings is substantially symmetrical along the plane at the midpoint.

[0289] 76A. The intraocular lens device of any one of Embodiments 1 A-75A, wherein the plurality of lateral openings are substantially evenly spaced about a circumference of the annular body; optionally wherein the plurality of lateral openings are substantially evenly spaced about a circumference at the outermost diameter of the annular body.

[0290] 77A. The intraocular lens device of any one of Embodiments 1 A-76A, wherein the plurality of lateral openings are positioned along the lateral portion of the annular body.

[0291] 78A. The intraocular lens device of any one of Embodiments 1 A-77A, wherein the plurality of lateral openings are substantially symmetrical along the lateral portion of the annular body.

[0292] 79A. The intraocular lens device of any one of Embodiments 1 A-78A, wherein the plurality of lateral openings are substantially evenly spaced about a circumference of thelateral portion of the annular body; optionally wherein the plurality of lateral openings are substantially evenly spaced about a circumference at the outermost diameter of the lateral portion of the annular body.

[0293] 80A. The intraocular lens device of any one of Embodiments 1 A-79A, wherein the plurality of lateral openings are positioned perpendicularly, substantially perpendicularly, and / or obliquely to the optical axis.

[0294] 81 A. The intraocular lens device of any one of Embodiments 1A-80A, wherein at least one lateral opening of the plurality of lateral openings has a height sufficient to accommodate a haptic of an IOL; optionally wherein each of the plurality of lateral openings has a height sufficient to accommodate a haptic of an IOL.

[0295] 82 A. The intraocular lens device of any one of Embodiments 1A-81A, wherein at least one lateral opening of the plurality of lateral openings has a height that is in the range of between about 15-75%, about 20-70%, about 25-60%, or about 25-50% of the height of the annular body; wherein each of the plurality of lateral openings has a height that is in the range of between 15-75%, 20-70%, 25-60%, or 25-50% of the height of the annular body.

[0296] 83 A. The intraocular lens device of any one of Embodiments 1 A-82A, wherein at least one lateral opening of the plurality of lateral openings has a height in the range of between about 500 microns to about 2 mm, about 600 microns to about 2 mm, about 750 microns to about 1.5 mm, or about 0.5 mm to about 1.0 mm; optionally wherein each of the plurality of lateral openings has a height in the range of between about 500 microns to about 2 mm, about 600 microns to about 2 mm, about 750 microns to about 1.5 mm, or about 0.5 mm and about 1.0 mm.

[0297] 84A. The intraocular lens device of any one of Embodiments 1 A-83A, wherein the at least one lateral opening has a rectangular profile; optionally wherein each of the plurality of lateral openings has a rectangular profile.

[0298] 85A. The intraocular lens device of any one of Embodiments 1 A-84A, wherein the at least one lateral opening has an elliptical profile; optionally wherein each of the plurality of lateral openings has an elliptical profile.

[0299] 86A. The intraocular lens device of any one of Embodiments 1 A-85A, wherein the at least one lateral opening has a trapezoidal profile; optionally wherein each of the plurality of lateral openings has a trapezoidal profile.

[0300] 87 A. The intraocular lens device of any one of Embodiments 1 A-86A, wherein at least one lateral opening of the plurality of lateral openings has a tapered profile such that a posterior portion of the at least one lateral opening has a width that is less than an anteriorportion of the at least one lateral opening; optionally wherein each of the plurality of lateral openings has a tapered profile such that each lateral opening of the plurality of lateral openings has a posterior portion has a width that is less than an anterior portion of said respective lateral opening.

[0301] 88A. The intraocular lens device of any one of Embodiments 1 A-87A, wherein the annular body has a thickness sufficient to provide adequate stiffness to maintain its shape upon insertion in the capsular bag.

[0302] 89 A. The intraocular lens device of any one of Embodiments 1 A-89A, wherein the annular body has a thickness in the range of between about 0.01-1.0 mm.

[0303] 90A. The intraocular lens device of Embodiment 89A, wherein the annular body has a thickness in the range of between about 0.01-0.05 mm, about 0.01-0.1 mm, about 0.01- 0.5 mm, about 0.01-1.0 mm, about 0.05-0.1 mm, about 0.05-0.5 mm, about 0.05-1.0 mm, about 0.1-0.5 mm, about 0.1-1.0 mm, or about 0.5-1.0 mm.

[0304] 91 A. The intraocular lens device of Embodiment 89 A or Embodiment 90 A, wherein the annular body has a thickness of about 0.01 mm, about 0.02 mm, about 0.03 mm, about 0.04 mm, about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, or about 1.0 mm.

[0305] 92 A. The intraocular lens device of any one of Embodiments 1 A-91 A, wherein the annular body has an interior surface and an outer surface.

[0306] 93 A. The intraocular lens device of any one of Embodiments 1 A-92A, wherein the interior surface of the annular body comprises a ridge.

[0307] 94A. The intraocular lens device of any one of Embodiments 1 A-93A, wherein the annular body forms an interior ridge on the interior surface between the anterior and posterior openings.

[0308] 95 A. The intraocular lens device of Embodiment 93 A or Embodiment 94A, wherein the ridge is configured for securing and / or retaining an intraocular lens.

[0309] 96A. The intraocular lens device of any one of Embodiments 93A-95A, wherein the ridge is configured for securing and / or retaining an intraocular lens.

[0310] 97 A. The intraocular lens device of any one of Embodiments 1 A-96A, wherein a portion of the annular body is substantially parallel to the optical axis.

[0311] 98 A. The intraocular lens device of any one of Embodiments 1 A-97A, wherein a portion of the annular body is substantially perpendicular to the plane of the anterior and posterior openings.

[0312] 99 A. The intraocular lens device of any one of Embodiments 1 A-98A, wherein the annular body comprises an internal cavity.

[0313] 100 A. The intraocular lens device of Embodiment 99 A, wherein the internal cavity of the annular body extends between the anterior portion and the posterior portion.

[0314] 101 A. The intraocular lens device of any one of Embodiments 99 A or 100 A, wherein the internal cavity of the annular body has a volume in the range of about 15-85 mm .

[0315] 102 A. The intraocular lens device of any one of Embodiments 99A-101 A, wherein the internal cavity of the annular body has a volume in the range of about 15-20 mm3, about 15-25 mm3, about 20-25 mm3, about 20-30 mm3, about 25-30 mm3, about 25-35 mm3, about 30-35 mm3, about 30-40 mm3, about 35-40 mm3, about 35-45 mm3, about 40-45 mm3, about 40-50 mm3, about 45-50 mm3, about 45-55 mm3, about 50-55 mm3, about 50-60 mm3, about 55-60 mm3, about 55-65 mm3, about 60-65 mm3, about 60-70 mm3, about 65-70 mm3, about 65-75 mm3, about 70-75 mm3, about 70-80 mm3, about 75-80 mm3, about 75-85 mm3, or about 80-85 mm3.

[0316] 103 A. The intraocular lens device of any one of Embodiments 99A-102A, wherein the internal cavity of the annular body has a volume of about 15 mm3, about 20 mm3, about mm3, about 30 mm3, about 35 mm3, about 40 mm3, about 45 mm3, about 50 mm3, about 55 mm3, about 60 mm3, about 65 mm3, about 70 mm3, about 75 mm3, about 80 mm3, or about 85 mm3.

[0317] 104A. The intraocular lens device of any one of Embodiments 1A-103A, wherein the anterior portion comprises a first volume and the posterior portion comprises a second volume.

[0318] 105 A. The intraocular lens device of Embodiment 104 A, wherein the anterior portion and the posterior portion have substantially equal volumes.

[0319] 106 A. The intraocular lens device of Embodiment 104 A or Embodiment 105 A, wherein the anterior portion has a greater volume than the posterior portion.

[0320] 107 A. The intraocular lens device of any one of Embodiments 104A-106A, wherein the posterior portion has a greater volume than the anterior portion.

[0321] 108 A. The intraocular lens device of any one of Embodiments 1 A- 107 A, wherein the annular body has a size that is substantially smaller than the size of a capsular bag.

[0322] 109 A. The intraocular lens device of any one of Embodiments 1 A- 108 A, wherein the annular body has a size that is 10-50% smaller than the size of a capsular bag.

[0323] 110 A. The intraocular lens device of any one of Embodiments 1 A- 109 A, whereinthe size of the annular body minimizes anterior, posterior, and / or radial protrusion of the annular body into the capsular bag.

[0324] 111 A. The intraocular lens device of any one of Embodiments 1 A-l 10 A, wherein the annular body has a volume that is substantially smaller than the volume of a capsular bag.

[0325] 112 A. The intraocular lens device of any one of Embodiments 1 A-l 11 A, wherein the annular body has a volume that is 10-50% smaller than the volume of a capsular bag.

[0326] 113A. The intraocular lens device of any one of Embodiments 1 A-l 12A, wherein the volume of the annular body minimizes anterior, posterior, and / or radial protrusion of the annular body into the capsular bag.

[0327] 114A. The intraocular lens device of any one of Embodiments 1 A-l 13A, wherein the shape of the annular body minimizes anterior, posterior, and / or radial protrusion of the annular body into the capsular bag.

[0328] 115 A. The intraocular lens device of any one of Embodiments 1 A-l 14A, wherein the curvature of the annular body is such that the tangent angle of a protruding haptic varies longitudinally along the annular body.

[0329] 116 A. The intraocular lens device of any one of Embodiments 1 A-l 15 A, wherein the plurality of haptics are arranged around the anterior portion; optionally wherein the plurality of haptics are arranged in a symmetrical pattern around the anterior portion.

[0330] 117 A. The intraocular lens device of any one of Embodiments 1 A-l 16A, wherein each of the plurality of haptics originates from positions proximal to the anterior opening; optionally wherein each of the plurality of haptics originates from positions radially symmetrical and proximal to the anterior opening.

[0331] 118 A. The intraocular lens device of any one of Embodiments 1 A-l 17A, wherein each of the plurality of haptics originate proximate to the anterior opening.

[0332] 119 A. The intraocular lens device of any one of Embodiments 1 A-l 18A, wherein the plurality of haptics radially extend from the anterior portion of the annular body.

[0333] 120 A. The intraocular lens device of any one of Embodiments 1 A-l 19A, wherein the plurality of haptics extend beyond the outermost perimeter of the annular body.

[0334] 121 A. The intraocular lens device of any one of Embodiments 1 A- 120 A, wherein the plurality of haptics extend laterally beyond the outermost diameter of the annular body.

[0335] 122 A. The intraocular lens device of any one of Embodiments 1 A- 121 A, wherein at least one haptic of the plurality of haptics extends at an angle in the range of between 30 degrees below and 30 degrees above a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0336] 123 A. The intraocular lens device of any one of Embodiments 1A-121A, wherein each haptic of the plurality of haptics extends at an angle in the range of between 30 degrees below and 30 degrees above a plane where the respective haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0337] 124 A. The intraocular lens device of any one of Embodiments 1 A- 121 A, wherein each haptic of the plurality of haptics extends at an angle in the range of between 20 degrees below and 20 degrees above a plane where said respective haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0338] 125 A. The intraocular lens device of any one of Embodiments 1 A- 121 A, wherein the plurality of haptics extend at an angle in the range of between 30 degrees below and 30 degrees above a plane where the plurality of haptics originates from the anterior portion of the annular body.

[0339] 126 A. The intraocular lens device of any one of Embodiments 1 A- 125 A, wherein the plurality of haptics extends in a posterior direction; optionally wherein the plurality of haptics extends in a posterior direction towards the plane bifurcating the anterior portion and the posterior portion.

[0340] 127A. The intraocular lens device of Embodiment 126A, wherein the degree of posteriorly-directed angulation of the plurality of haptics is between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below a plane where at least one haptic of the plurality of haptics originates from the anterior portion.

[0341] 128A. The intraocular lens device of Embodiment 126A or Embodiment 127A, wherein the degree of posteriorly-directed angulation of the plurality of haptics is about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 degrees below a plane where at least one haptic of the plurality of haptics originates from the anterior portion.

[0342] 129 A. The intraocular lens device of any one of Embodiments 126A-128A, wherein the degree of posteriorly-directed angulation of the plurality of haptics is 10 degrees below a plane where at least one haptic of the plurality of haptics originates from the anterior portion.

[0343] 130A. The intraocular lens device of any one of Embodiments 1 A- 129 A, wherein at least one haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0344] 131 A. The intraocular lens device of any one of Embodiments 1A-130A, whereineach haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below a plane where the respective haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0345] 132A. The intraocular lens device of any one of Embodiments 1A-131A, wherein the plurality of haptics extend at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below a plane where the plurality of haptics originates from the anterior portion of the annular body.

[0346] 133A. The intraocular lens device of any one of Embodiments 1A-125A, wherein the plurality of haptics extends in an anterior direction; optionally wherein the plurality of haptics extends in an anterior direction away from the plane bifurcating the anterior portion and the posterior portion.

[0347] 134A. The intraocular lens device of any one of Embodiments 1A-125A orEmbodiment 133A, wherein the plurality of haptics extends in an anterior direction and above the plane of the anterior opening.

[0348] 135 A. The intraocular lens device of any one of Embodiments 1 A- 125 A,Embodiment 133A or Embodiment 134A, wherein the degree of anteriorly-directed angulation of the plurality of haptics is between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees above a plane where at least one haptic of the plurality of haptics originates from the anterior portion.

[0349] 136A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 133A-135A, wherein the degree of anteriorly-directed angulation of the plurality of haptics is about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 degrees above a plane where at least one haptic of the plurality of haptics originates from the anterior portion.

[0350] 137A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 133A-136A, wherein the degree of anteriorly-directed angulation of the plurality of haptics is 10 degrees above a plane where at least one haptic of the plurality of haptics originates from on the anterior portion.

[0351] 138A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 133A-137A, wherein at least one haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees above a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0352] 139A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 133A-138A, wherein each haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7- 20 degrees, or about 12-25 degrees above a plane where the respective haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0353] 140 A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 133A-139A, wherein the plurality of haptics extend at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees above a plane where the plurality of haptics originates from the anterior portion of the annular body.

[0354] 141 A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiment 140A, wherein the plurality of haptics extends in a direction substantially parallel to the plane bifurcating the anterior portion and the posterior portion.

[0355] 142 A. The intraocular lens device of any one of Embodiments 1 A- 125 A,Embodiment 140 A or Embodiment 141 A, wherein the plurality of haptics extends in a direction substantially parallel to a plane perpendicular to the optical axis.

[0356] 143A. The intraocular lens device of any one of Embodiments 1A-125A orEmbodiments 140A-142A, wherein the plurality of haptics extends in a direction substantially parallel to a plane where at least one haptic of the plurality of haptics originates from the anterior portion.

[0357] 144 A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 140A-143A, wherein the plurality of haptics extends beyond the an outermost perimeter of the annular body at an angle such that the plurality is substantially coplanar with the anterior opening.

[0358] 145 A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 140A-144A, wherein at least one haptic of the plurality of haptics extends at an angle substantially parallel to a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0359] 146 A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 140A-145A, wherein each haptic of the plurality of haptics extends at an angle substantially parallel to a plane where the respective haptic of the plurality of haptics originates from the anterior portion of the annular body.

[0360] 147 A. The intraocular lens device of any one of Embodiments 1 A- 125 A orEmbodiments 140A-146A, wherein the plurality of haptics extend at an angle substantiallyparallel to a plane where the plurality of haptics originates from the anterior portion of the annular body.

[0361] 148 A. The intraocular lens device of any one of Embodiments 1 A- 147 A, wherein each of the plurality of haptics originates on substantially a single plane.

[0362] 149 A. The intraocular lens device of any one of Embodiments 1 A- 148 A, wherein the plurality of haptics are configured to be substantially rotationally symmetric with respect to the optical axis.

[0363] 150A. The intraocular lens device of any one of Embodiments 1A-149A, wherein the plurality of haptics are configured to be substantially radially symmetric with respect to the optical axis.

[0364] 151A. The intraocular lens device of any one of Embodiments 1A-150A, wherein the plurality of haptics comprises 2-6 haptics.

[0365] 152 A. The intraocular lens device of any one of Embodiments 1A-151A, wherein the plurality of haptics comprises 2, 3, 4, 5, or 6 haptics.

[0366] 153A. The intraocular lens device of any one of Embodiments 1A-152A, wherein the plurality of haptics comprises of two diametrically opposed haptics.

[0367] 154 A. The intraocular lens device of any one of Embodiments 1 A- 152 A, wherein the plurality of haptics comprises of three trigonally positioned haptics.

[0368] 155 A. The intraocular lens device of any one of Embodiments 1 A- 152 A, wherein the plurality of haptics comprises of four equally spaced haptics.

[0369] 156A. The intraocular lens device of any one of Embodiments 1A-155A, wherein the plurality of haptics are flexible.

[0370] 157A. The intraocular lens device of any one of Embodiments 1A-156A, wherein the plurality of haptics are collapsible.

[0371] 158A. The intraocular lens device of any one of Embodiments 1A-157A, wherein the plurality of haptics are deformable; optionally wherein the plurality of haptics are deformable for insertion into a capsular bag of an eye.

[0372] 159A. The intraocular lens device of any one of Embodiments 1A-158A, wherein the plurality of haptics are self-expandable; optionally wherein the plurality of haptics are self-expandable upon insertion into a capsular bag of an eye.

[0373] 160A. The intraocular lens device of any one of Embodiments 1A-159A, wherein at least one haptic or each of the plurality of haptics has a wire shape.

[0374] 161 A. The intraocular lens device of any one of Embodiments 1 A- 160 A, wherein at least one haptic or each of the plurality of haptics has a boomerang wire shape.

[0375] 162 A. The intraocular lens device of any one of Embodiments 1A-161A, wherein at least one haptic or each of the plurality of haptics has an arcing wire shape.

[0376] 163A. The intraocular lens device of any one of Embodiments 1A-162A, wherein at least one haptic or each of the plurality of haptics has a thin, cylindrical wire shape.

[0377] 164A. The intraocular lens device of any one of Embodiments 1A-163A, wherein at least one haptic or each of the plurality of haptics has a petal-like shape.

[0378] 165 A. The intraocular lens device of any one of Embodiments 1 A- 164 A, wherein at least one haptic or each of the plurality of haptics comprises a first substantially linear portion, an arcuate portion, and a second substantially linear portion.

[0379] 166 A. The intraocular lens device of any one of Embodiments 1 A- 165 A, wherein at least one haptic or each of the plurality of haptics has a point of peak convexity.

[0380] 167 A. The intraocular lens device of any one of Embodiments 1 A- 166 A, wherein at least one haptic or each of the plurality of haptics comprises a parabolic arc.

[0381] 168 A. The intraocular lens device of any one of Embodiments 1 A- 167 A, wherein at least one haptic or each of the plurality of haptics extend radially from the anterior portion and then curve back towards the anterior portion.

[0382] 169 A. The intraocular lens device of any one of Embodiments 1 A- 168 A, wherein each of the plurality of haptics has a cross-sectional diameter between about 0.001-1.5 mm.

[0383] 170A. The intraocular lens device of Embodiment 169A, wherein each of the plurality of haptics has a cross-sectional diameter between about 0.001-0.01 mm, about 0.001-0.1 mm, about 0.01-1.0 mm, about 0.1-1.0 mm, about 0.1-0.5 mm, about 0.5-1.5 mm, about 0.5- 1.0 mm, or about 1.0-1.5 mm.

[0384] 171 A. The intraocular lens device of Embodiment 169A or Embodiment 170A, wherein each of the plurality of haptics has a cross-sectional diameter of about 0.01 mm, about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.1 mm, about 0.11 mm, about 0.12 mm, about 0.13 mm, about 0.14 mm, about 0.15 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, or about 1.5 mm.

[0385] 172 A. The intraocular lens device of any one of Embodiments 1A-171A, wherein at least one haptic or each of the plurality of haptics has a pathlength in the range of between about 10-16 mm.

[0386] 173 A. The intraocular lens device of Embodiment 172A, wherein at least one haptic or each of the plurality of haptics has a pathlength in the range of between about 10-12mm, about 10-12 mm, about 10-13 mm, about 12-13 mm, about 12-14 mm, about 13-14 mm, about 13-15 mm, about 14-15 mm, about 14-16 mm, or about 15-16 mm.

[0387] 174A. The intraocular lens device of Embodiment 172A or Embodiment 173 A, wherein at least one haptic or each of the plurality of haptics has a pathlength of about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0388] 175 A. The intraocular lens device of any one of Embodiments 1 A- 174 A, wherein a wingspan between two diametrically opposed haptics of the plurality of haptics comprises the distance between the points of peak convexity of each haptic.

[0389] 176A. The intraocular lens device of Embodiment 175A, wherein a configuration comprising two haptics has a wingspan that is in the range of between about 5.0-16 mm.

[0390] 177A. The intraocular lens device of Embodiment 175A or Embodiment 176A, wherein a configuration comprising two haptics has a wingspan that is in the range of between about 5-8 mm, about 5-11 mm, about 5-14 mm, about 5-16, about 6-9 mm, about 6- 12 mm, about 6-15 mm, about 6-16 mm, about 7-10 mm, about 7-13 mm, about 7-16 mm, about 8-11 mm, about 8-14 mm, about 8-16 mm, about 9-12 mm, about 9-14 mm, about 9-16 mm, about 10-12 mm, about 10-14 mm, about 10-16 mm, about 11-13 mm, about 11-16 mm, about 12-14 mm, about 12-16 mm, about 13-15 mm, about 13-16 mm, about 14-15 mm, about 14-16 mm, or about 15-16 mm.

[0391] 178A. The intraocular lens device of any one of Embodiments 175A-177A, wherein a configuration comprising two haptics has a wingspan that is about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0392] 179A. The intraocular lens device of any one of Embodiments 1A-178A, wherein a single haptic has a curve at the point of peak convexity comprising a radius in the range of between about 3-15 mm.

[0393] 180A. The intraocular lens device of Embodiment 179A, wherein a single haptic has a curve at the point of peak convexity comprising a radius in the range of between about 3-4 mm, about 3-5 mm, about 4-5 mm, about 4-6 mm, about 5-6 mm, about 5-7 mm, about 6- 7 mm, about 6-8 mm, about 7-8 mm, about 7-9 mm, about 8-9 mm, about 8-10 mm, about 9- 10 mm, about 9-11 mm, about 10-11 mm, about 10-12 mm, about 11-12 mm, about 11-13 mm, about 12-13 mm, about 12-14 mm, about 13-14 mm, about 13-15 mm, or about 14-15 mm.

[0394] 181 A. The intraocular lens device of Embodiment 179A or Embodiment 180A, wherein a single haptic has a curve at the point of peak convexity comprising a radius ofabout 3.0 mm, about 4.0 mm, about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0395] 182 A. The intraocular lens device of any one of Embodiments 1A-181A, wherein the plurality of haptics are suitable for pressing against the tissue of the sulcus of the eye upon implantation.

[0396] 183A. The intraocular lens device of any one of Embodiments 1A-182A, wherein the plurality of haptics are suitable for supporting the device within a capsular bag upon implantation in an eye.

[0397] 184A. The intraocular lens device of any one of Embodiments 1A-183A, wherein the device has a weight in the range of between about 5-250 mg.

[0398] 185 A. The intraocular lens device of Embodiment 184A, wherein the device has a weight in the range of between about 5-10 mg, about 5-15 mg, about 5-25 mg, about 5-35 mg, about 5-45 mg, about 5-55 mg, about 5-65 mg, about 5-70 mg about 10-15 mg, about 10- 20 mg, about 10-30 mg, about 10-40 mg, about 10-50 mg, about 10-60 mg, about 10-70 mg, about 15-25 mg, about 15-35 mg, about 15-45 mg, about 15-55 mg, about 15-65 mg, about20-25 mg, about 25-30 mg, about 25-35 mg, about 30-35 mg, about 35-40 mg, about 35-45 mg, about 40-45 mg, about 45-50 mg, about 45-55 mg, about 50-55 mg, about 55-60 mg, about 55-65 mg, about 60-65 mg, about 60-70 mg, about 65-70 mg, about 5-100 mg, about 5-125 mg, about 5-150 mg, about 5-175 mg, about 5-200 mg, about 5-225 mg, about 5-250 mg, about 50-100 mg, about 50-125 mg, about 50-150 mg, about 50-175 mg, about 50-200 mg, about 50-225 mg, about 50-250 mg, about 100-125 mg, about 100-150 mg, about 100-175 mg, about 100-200 mg, about 100-225 mg, about 100-250 mg, about 150-175 mg, about 150- 200 mg, about 150-225 mg, or about 150-250 mg.

[0399] 186A. The intraocular lens device of Embodiment 184A or Embodiment 185 A, wherein the device has a weight of about 5.0 mg, about 10 mg, about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg, about 40 mg, about 45 mg, about 50 mg, about 55 mg, about 60 mg, about 65 mg, about 70 mg, about 100 mg, about 125 mg, about 150 mg, about 175 mg, about 200 mg, about 225 mg, or about 250 mg.

[0400] 187 A. The intraocular lens device of any one of Embodiments 1 A- 186 A, wherein the plurality of haptics are configured to support the weight of the device.

[0401] 188A. The intraocular lens device of any one of Embodiments 1A-187A, wherein each of the plurality of haptics extends smoothly from the anterior portion of the annular body.

[0402] 189A. The intraocular lens device of any one of Embodiments 1A-188A, wherein at least one haptic or each of the plurality of haptics has a smooth surface along the entire length of the haptic.

[0403] 190 A. The intraocular lens device of any one of Embodiments 1 A- 189 A, wherein the plurality of haptics are configured to be non-abrasive and / or non-irritating to the sulcus of an eye.

[0404] 191 A. The intraocular lens device of any one of Embodiments 1 A- 190 A, wherein the plurality of haptics are configured to be non-abrasive and / or non-irritating to the cornea of an eye.

[0405] 192 A. The intraocular lens device of any one of Embodiments 1A-191A, wherein at least one haptic or each of the plurality of haptics comprises an eyelet for surgical suturing, optionally sufficient for allowing a 10-0 proline or vortex suture to pass through said eyelet.

[0406] 193 A. The intraocular lens device of any one of Embodiments 1A-192A, wherein a single haptic of the plurality of haptics has a tensile strength in the range of between about 10-80 MPa.

[0407] 194A. The intraocular lens device of Embodiment 193 A, wherein a single haptic of the plurality of haptics has a tensile strength in the range of between about 10-15 MPa, about 10-20 MPa, about 15-20 MPa, about 15-25 MPa, about 20-25 MPa, about 20-30 MPa, about 25-30 MPa, about 25-35 MPa, about 30-35 MPa, about 30-40 MPa, about 35-40 MPa, about 35-45 MPa, about 40-45 MPa, about 40-50 MPa, about 45-50 MPa, about 45-55 MPa, about 50-55 MPa, about 50-60 MPa, about 55-60 MPa, about 55-65 MPa, about 60-65 MPa, about 60-70 MPa, about 65-70 MPa, about 65-75 MPa, about 70-75 MPa, about 70-80 MPa, or about 75-80 MPa.

[0408] 195A. The intraocular lens device of Embodiment 193A or Embodiment 194A, wherein a single haptic of the plurality of haptics has a tensile strength of about 10 MPa, about 15 MPa, about 20 MPa, about 25 MPa, about 30 MPa, about 35 MPa, about 40 MPa, about 45 MPa, about 50 MPa, about 55 MPa, about 60 MPa, about 65 MPa, about 70 MPa, about 75 MPa, or about 80 MPa.

[0409] 196 A. The intraocular lens device of any one of Embodiments 1 A- 195 A, wherein a single haptic of the plurality of haptics has a stiffness in the range of between about 50-100 N / m2.

[0410] 197 A. The intraocular lens device of Embodiment 196 A, wherein a single haptic of the plurality of haptics has a stiffness in the range of between about 50-55 N / m2, about 50- 60 N / m2, about 55-60 N / m2, about 55-65 N / m2, about 60-65 N / m2, about 60-70 N / m2, about65-70 N / m2, about 65-75 N / m2, about 70-75 N / m2, about 70-80 N / m2, about 75-80 N / m2, about 75-85 N / m2, about 80-85 N / m2, about 80-90 N / m2, about 85-90 N / m2, about 85-95 N / m2, about 90-95 N / m2, about 90-100 N / m2, or about 95-100 N / m2.

[0411] 198 A. The intraocular lens device of Embodiment 196 A or Embodiment 197 A, wherein a single haptic of the plurality of haptics has a stiffness of about 50 N / m2, about 55 N / m2, about 60 N / m2, about 65 N / m2, about 70 N / m2, about 75 N / m2, about 80 N / m2, about 85 N / m2, about 90 N / m2, about 95 N / m2, or about 100 N / m2.

[0412] 199 A. The intraocular lens device of any one of Embodiments 1 A- 198 A, wherein the plurality of haptics support a weight in the range of between about 10-125 mg.

[0413] 200 A. The intraocular lens device of Embodiment 199 A, wherein the plurality of haptics support a weight in the range of between about 10-30 mg, about 10-50 mg, about 10- 70 mg, about 10-90 mg, about 10-110 mg, about 20-40 mg, about 20-60 mg, about 20-80 mg, about 20-100 mg, about 20-120 mg, about 30-50 mg, about 30-70 mg, about 30-90 mg, about 30-110 mg, about 40-60 mg, about 40-80 mg, about 40-100 mg, about 40-120 mg, about SO- 75 mg, about 50-95 mg, about 50-115 mg, about 50-125 mg, about 60-85 mg, about 60-105 mg, about 60-125 mg, about 75-95 mg, about 75-115 mg, about 75-125 mg, about 85-105 mg, about 80-125 mg, about 90-100 mg, about 90-110 mg, about 90-125 mg, about 100-115 mg, or about 100-125 mg.

[0414] 201 A. The intraocular lens device of Embodiment 199 A or Embodiment 200 A, wherein the plurality of haptics support a weight of about 5.0 mg, about 10 mg, about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg, about 40 mg, about 45 mg, about 50 mg, about 55 mg, about 60 mg, about 65 mg, about 70 mg, about 75 mg, about 80 mg, about 85 mg, about 90 mg, about 95 mg, or about 100 mg.

[0415] 202 A. The intraocular lens device of any one of Embodiments 1A-201A, wherein two diametrically opposed haptics allow radially-directed compression in the range of between about 5.0-15.0 mm, optionally about 5.0-10.0 mm.

[0416] 203A. The intraocular lens device of any one of Embodiments 1A-201A, wherein three trigonally positioned haptics allow radially-directed compression in the range of between about 3.0-15.0 mm, optionally about 3.0-8.0 mm.

[0417] 204 A. The intraocular lens device of any one of Embodiments 1A-201A, wherein four equally spaced haptics allow radially-directly compression in the range of between about 1.0-15.0 mm, optionally about 1.0-6.0 mm.

[0418] 205 A. The intraocular lens device of any one of Embodiments 1A-204A, wherein the anterior opening has at least one dimension sufficiently large to permit the insertion of anIOL.

[0419] 206 A. The intraocular lens device of any one of Embodiments 1A-205A, wherein the anterior opening has at least one dimension sufficiently large to permit the insertion of an IOL with a radius in the range of between about 4.0-8.0 mm.

[0420] 207 A. The intraocular lens device of any one of Embodiments 1A-206A, wherein the anterior opening has a circular shape.

[0421] 208 A. The intraocular lens device of any one of Embodiments 1A-207A, wherein the anterior opening has a diameter that is in the range of between about 2.0-8.0 mm.

[0422] 209A. The intraocular lens device of Embodiment 208 A, wherein the anterior opening has a diameter that is in the range of between about 3-4 mm, about 3-5 mm, about 3- 6 mm, about 3-7 mm, about 4-5 mm, about 4-6 mm, about 4-7 mm, about 4-8 mm, about 5-6 mm, about 5-7 mm, about 5-8 mm, about 6-7 mm, about 6-8 mm, or about 7-8 mm.

[0423] 210A. The intraocular lens device of Embodiment 208 A or Embodiment 209 A, wherein the anterior opening has a diameter of about 3.0 mm, about 4.0 mm, about 5.0 mm, about 6.0 mm, about 7.0 mm, or about 8.0 mm.

[0424] 211 A. The intraocular lens device of any one of Embodiments 1 A-210A, wherein the posterior portion overlaps a portion of the anterior opening.

[0425] 212A. The intraocular lens device of any one of Embodiments 1 A-211 A, wherein the posterior portion radially overlaps 5-50% of the anterior opening.

[0426] 213A. The intraocular lens device of any one of Embodiments 1A-212A, wherein the anterior opening comprises a rim having a squared edge, a rounded edge, or a tapered edge.

[0427] 214A. The intraocular lens device of any one of Embodiments 1A-213A, wherein the anterior opening is larger than the posterior opening.

[0428] 215 A. The intraocular lens device of any one of Embodiments 1 A-214 A, wherein the posterior opening has at least one dimension sufficiently small to prevent the insertion of an IOL.

[0429] 216A. The intraocular lens device of any one of Embodiments 1 A-215 A, wherein the posterior opening has at least one dimension sufficiently small to prevent an inserted IOL from falling into the vitreous upon implantation into the eye of a subject.

[0430] 217A. The intraocular lens device of any one of Embodiments 1 A-216 A, wherein the posterior opening has at least one dimension sufficiently small to prevent the insertion of a collapsed, compressed and / or folded IOL.

[0431] 218A. The intraocular lens device of any one of Embodiments 1 A-217 A, whereinthe posterior opening has a smaller dimension than the anterior opening.

[0432] 219A. The intraocular lens device of any one of Embodiments 1A-218A, wherein the posterior opening is not wide enough to block the optical axis.

[0433] 220 A. The intraocular lens device of any one of Embodiments 1A-219A, wherein the posterior opening has a circular shape.

[0434] 221 A. The intraocular lens device of any one of Embodiments 1A-220A, wherein the posterior opening is smaller than the anterior opening in the range of between about 10- 70%.

[0435] 222 A. The intraocular lens device of Embodiment 221 A, wherein the posterior opening is smaller than the anterior opening in the range of between about 10-15 %, about 10-20 %, about 15-20 %, about 15-25 %, about 20-25 %, about 20-30 %, about 25-30 %, about 25-35 %, about 30-35 %, about 30-40 %, about 35-40 %, about 35-45 %, about 40-45 %, about 40-50 %, about 45-50 %, about 45-55 %, about 50-55 %, about 50-60 %, about 55- 60 %, about 55-65 %, about 60-65 %, about 60-70 %, or about 65-70 %.

[0436] 223 A. The intraocular lens device of Embodiment 221 A or Embodiment 222A, wherein the posterior opening is smaller than the anterior opening by about 10 %, about 15 %, about 20 %, about 25 %, about 30 %, about 35 %, about 40 %, about 45 %, about 50 %, about 55 %, about 60 %, about 65 %, or about 70 %.

[0437] 224A. The intraocular lens device of any one of Embodiments 1A-223A, wherein the posterior opening has a diameter that is in the range of between about 1.5-5.5 mm.

[0438] 225 A. The intraocular lens device of Embodiment 224A, wherein the posterior opening has a diameter in the range of between about 1.5-2.0 mm, about 1.5-2.5 mm, about 1.5-3.5 mm, about 2.0-2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, about 3.0-3.5 mm, about 3.5-4.0 mm, about 3.5-4.5 mm, about 4.0-4.5 mm, about 4.5-5.0 mm, about 4.5-5.5 mm, or about 5.0-5.5 mm.

[0439] 226A. The intraocular lens device of Embodiment 224A or Embodiment 225 A, wherein the posterior opening has a diameter of about 2.0 mm, about 3.0 mm, about 3.5 mm, about 4.0 mm, about 4.5 mm, about 5.0 mm, or about 5.5 mm.

[0440] 227 A. The intraocular lens device of any one of Embodiments 1A-226A, wherein the posterior opening comprises a rim having a squared edge, a rounded edge, or a tapered edge.

[0441] 228 A. The intraocular lens device of any one of Embodiments 1A-227A, wherein the anterior portion comprises a gutter, track, well, or reservoir is proximal to the anterior opening.

[0442] 229A. The intraocular lens device of Embodiment 228 A, wherein the gutter, track, well, or reservoir is suitable for containing and / or eluting a drug component, optionally wherein the gutter, track, well, or reservoir comprises fenestrations that allow for drug elution.

[0443] 230A. The intraocular lens device of Embodiment 228A or Embodiment 229A, wherein the gutter, track, well, or reservoir has a diameter of about 0.1-3.0 mm.

[0444] 231 A. The intraocular lens device of any one of Embodiments 228A-230A, wherein the gutter, track, well, or reservoir has a diameter that is in the range of between about 0.1-0.5 mm, about 0.1-1.0 mm, about 0.1-1.5 mm, about 0.1-2.0 mm, about 0.1-2.5 mm, about 0.1-3.0 mm, about 0.5-1.0 mm, about 0.5-1.5 mm, about 0.5-2.0 mm, about 0.5- 2.5 mm, about 0.5-3.0 mm, about 1.0-1.5 mm, about 1.0-2.0 mm, about 1.0-2.5 mm, about 1.0-3.0 mm, about 1.5-2.0 mm, about 1.5-2.5 mm, about 1.5-3.0 mm, about 2.0-2.5 mm, about 2.0-3.0 mm, or about 2.5-3.0 mm.

[0445] 232A. The intraocular lens device of any one of Embodiments 228A-231 A, wherein the gutter, track, well, or reservoir has a diameter of about 0.1 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, or about 3.0 mm.

[0446] 233A. The intraocular lens device of any one of Embodiments 228A-232A, wherein the gutter, track, well, or reservoir has a volume capacity of about 9 microliters.

[0447] 234A. The intraocular lens device of any one of Embodiments 1A-233A, wherein the annular body is hydrophobic.

[0448] 235A. The intraocular lens device of any one of Embodiments 1A-234A, wherein the plurality of haptics is hydrophobic.

[0449] 236 A. The intraocular lens device of any one of Embodiments 1A-235A, wherein the device is hydrophobic.

[0450] 237A. The intraocular lens device of any one of Embodiments 1A-233A, wherein the annular body is hydrophilic.

[0451] 238A. The intraocular lens device of any one of Embodiments 1A-233A orEmbodiment 237A, wherein the plurality of haptics is hydrophilic.

[0452] 239A. The intraocular lens device of any one of Embodiments 1 A-233A,Embodiment 237A or Embodiment 238A, wherein the device is hydrophilic.

[0453] 240 A. The intraocular lens device of any one of Embodiments 1A-239A, wherein a collapsed, compressed and / or folded device has a length of about 14 mm.

[0454] 241 A. An intraocular lens system, comprising an intraocular lens (IOL) within the cavity of the intraocular lens device of any one of Embodiments 1 A-240A.

[0455] 242 A. The intraocular lens system of Embodiment 241 A, wherein the intraocular lens system has a diameter of less than about 2.2 mm when collapsed, compressed and / or folded.

[0456] 243 A. The intraocular lens system of Embodiment 241 A or Embodiment 242A, wherein the intraocular lens system has a length of about 14 mm when collapsed, compressed and / or folded.

[0457] 244A. The intraocular lens system of any one of Embodiments 241A-243A, wherein the IOL is hydrophobic.

[0458] 245A. The intraocular lens system of any one of Embodiments 241A-243A, wherein the IOL is hydrophilic.

[0459] 246 A. The intraocular lens system of any one of Embodiments 241A-245A, wherein the optical diameter of the IOL is between about 10-15 mm.

[0460] 247 A. The intraocular lens system of Embodiment 246 A, wherein the optical diameter of the IOL is between about 4-6 mm, about 4-8 mm, about 4-10 mm, about 4-12 mm, about 6-8 mm, about 6-10 mm, about 6-12 mm, about 8-10 mm, about 8-12 mm, about 10-12 mm, about 10-15 mm, about 12-14 mm, about 12-15 mm, or about 14-15 mm.

[0461] 248 A. The intraocular lens system of Embodiment 246 A or Embodiment 247 A, wherein the diameter of the IOL is 10-15 mm.

[0462] 249 A. The intraocular lens system of any one of Embodiments 241A-248A, wherein the intraocular lens device comprises 1, 2, or 3 IOLS.

[0463] 250A. The intraocular lens system of any one of Embodiments 241A-248A, wherein the intraocular lens device contains no more than 1 or 2 IOLs.

[0464] 251 A. A method of implanting an intraocular lens (IOL) into the eye of a subject, comprising: i) injecting the intraocular lens device of any one of Embodiments 1A-240A into an eye of a subject; optionally into a capsular bag of an eye of a subject; and ii) injecting an intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

[0465] 252A. The method of Embodiment 251 A, wherein the IOL is hydrophobic.

[0466] 253 A. The method of Embodiment 251 A, wherein the IOL is hydrophilic.

[0467] 254A. The method of any one of Embodiments 251A-253A, wherein the method further comprises injecting a second intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

[0468] 255 A. The method of any one of Embodiments 251A-254A, wherein the method further comprises injecting a second intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

[0469] 256A. The method of any one of Embodiments 251A-255A, wherein the optical diameter of the IOL is between about 10-15 mm.

[0470] 257A. The method of any one of Embodiments 251A-256A, wherein the optical diameter of the IOL is between about 4-6 mm, about 4-8 mm, about 4-10 mm, about 4-12 mm, about 6-8 mm, about 6-10 mm, about 6-12 mm, about 8-10 mm, about 8-12 mm, about 10-12 mm, about 10-15 mm, about 12-14 mm, about 12-15 mm, or about 14-15 mm.

[0471] 258A. The method of any one of Embodiments 251A-257A, wherein a minimum incision length of the subject’s eye for implantation of the intraocular lens device is about 2.2 mm.

[0472] 259A. The method of any one of Embodiments 251A-258A, wherein a minimum incision length of the subject’s eye for implantation of the intraocular lens device is between about 1.0-4.0 mm.

[0473] 260A. The method of any one of Embodiments 251A-259A, wherein a minimum incision length of the subject’s eye for implantation of the intraocular lens device is in the range of between about 1.5-2.0 mm, about 1.5-2.5 mm, about 2.0-2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, or about 3.0-3.5 mm.

[0474] 261 A. The method of any one of Embodiments 251A-260A, wherein a minimum incision length of the subject’s eye for implantation of the intraocular lens device is about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, or about 3.5 mm.

[0475] 262 A. A method of implanting an intraocular lens (IOL) into the eye of a subject, comprising injecting the intraocular lens system of any one of Embodiments 241 A-250A into an eye of a subject.

[0476] 263 A. The method of Embodiment 262A, wherein a minimum incision length of the subject’s eye for implantation of the intraocular lens system is about 2.2 mm.

[0477] 264A. The method of Embodiment 262A or Embodiment 263 A, wherein aminimum incision length of the subject’s eye for implantation of the intraocular lens system is between about 1.0-4.0 mm.

[0478] 265 A. The method of any one of Embodiments 262A-264A, wherein a minimum incision length of the subject’s eye for implantation of the intraocular lens system is in the range of between about 1.5-2.0 mm, about 1.5-2.5 mm, about 2.0-2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, or about 3.0-3.5 mm.

[0479] 266A. The method of any one of Embodiments 262A-265A, wherein a minimum incision length of the subject’s eye for implantation of the intraocular lens system is about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, or about 3.5 mm.

[0480] 267 A. A method of implanting an intraocular lens (IOL) into the eye of a subject, comprising: i) injecting the intraocular lens device of any one of Embodiments 1A-240A into an eye of a subject, wherein the eye of the subject lacks a capsular bag or has a damaged capsular bag; ii) securing the intraocular lens device within the eye of the subject by employing a de-roofed needle and thread to externalize and affix a portion of two haptics of the plurality of haptics through the sclera of the eye of the subject; and iii) injecting an intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

[0481] 267 A. A method of implanting an intraocular lens (IOL) into the eye of a subject, comprising: i) injecting the intraocular lens system of any one of Embodiments 241A-250A into an eye of a subject, wherein the eye of the subject lacks a capsular bag or has a damaged capsular bag; and ii) securing the intraocular lens device within the eye of the subject by employing a de-roofed needle and thread to externalize and affix a portion of two haptics of the plurality of haptics through the sclera of the eye of the subject.

[0482] IB. In an Embodiment, an intraocular lens device, comprising: i) an intraocular ring that is radially centered along an optical axis; ii) a plurality of haptics extending from the intraocular ring; andiii) a plurality of loops extending from the intraocular ring and substantially perpendicular to the optical axis.

[0483] 2B. The intraocular lens device of Embodiment IB, wherein each of the plurality of loops extend anteriorly from the intraocular ring relative to a plane of the intraocular ring.

[0484] 3B. The intraocular lens device of Embodiment IB, wherein each of the plurality of loops extend posteriorly from the intraocular ring relative to a plane of the intraocular ring.

[0485] 4B. The intraocular lens device of any one of Embodiments 1B-3B, wherein the intraocular ring comprises a substantially toroidal body portion.

[0486] 5B. The intraocular lens device of Embodiment 4B, wherein the toroidal body portion has a substantially square cross-sectional shape, a substantially rectangular cross- sectional shape, a substantially circular cross-sectional shape, a substantially oval cross- sectional shape, a substantially trapezoidal cross-sectional shape, or a substantially hexagonal cross-sectional shape.

[0487] 6B. The intraocular lens device of Embodiments 1B-3B, wherein the intraocular ring comprises an annular body portion having a substantially cylindrical shape; optionally wherein the intraocular ring comprises an annular body portion having a cylindrical shape.

[0488] 7B. The intraocular lens device of any one of Embodiments 1B-6B, wherein the plurality of loops comprises 2-4, 2-6, or 2-8 loops.

[0489] 8B. The intraocular lens device of any one of Embodiments 1B-6B, wherein the plurality of loops comprises 2, 3, 4, 5, 6, 7, or 8 loops.

[0490] 9B. The intraocular lens device of any one of Embodiments 1B-7B, wherein the plurality of loops comprises at least a first loop substantially opposite at least a second loop.

[0491] 10B. The intraocular lens device of any one of Embodiments 1B-9B, wherein the plurality of loops comprises at least a third loop substantially opposite at least a fourth loop.

[0492] 1 IB. The intraocular lens device of any one of Embodiments 1B-10B, wherein the plurality of loops are substantially evenly spaced about a circumference of the intraocular ring.

[0493] 12B. The intraocular lens device of any one of Embodiments IB-1 IB, wherein the plurality of loops are positioned perpendicularly, substantially perpendicularly, and / or obliquely to the optical axis.

[0494] 13B. The intraocular lens device of any one of Embodiments 1B-12B, wherein at least one loop or each of the plurality of loops has a height sufficient to accommodate a haptic of an IOL.

[0495] 14B. The intraocular lens device of any one of Embodiments 1B-13B, wherein atleast one loop or each loop of the plurality of loops has a diameter in the range of between about 500 microns to about 4 mm, about 600 microns to about 3.5 mm, about 750 microns to about 1.5 mm, about 1.0 mm to about 2.0 mm, about 1.0 mm to about 3.0 mm, about 1.0 mm to about 3.5 mm, about 1.5 mm to about 2.5 mm, about 1.5 mm to about 2.5 mm, about 2.0 to about 3.0 mm, about 2.0 mm to about 3.5 mm, about 2.5 mm to about 3.0 mm, about 2.5 to about 3.5 mm, or about 0.5 mm to about 1.0 mm; optionally wherein at least one loop or each of the plurality of loops has a diameter of about 500 microns, about 1.0 mm, about 1.5 mm, about 1.75 mm, about 2.0 mm, about 2.25 mm, about 2.5 mm, about 2.75 mm, about 3.0 mm, about 3.25 mm, or about 3.5 mm.

[0496] 15B. The intraocular lens device of any one of Embodiments 1B-14B, wherein at least one loop or each of the plurality of loops has a substantially toroidal shape, a substantially tubular shape, a substantially square shape, a substantially rectangular shape, a substantially elliptical shape, a substantially circular shape, a substantially oval shape, a substantially trapezoidal shape, or a substantially hexagonal shape, or combinations thereof.

[0497] 16B. The intraocular lens device of Embodiment 15B, wherein the at least one loop or each of the plurality of loops has a substantially square cross-sectional shape, a substantially rectangular cross-sectional shape, a substantially circular cross-sectional shape, a substantially oval cross-sectional shape, a substantially trapezoidal cross-sectional shape, or a substantially hexagonal cross-sectional shape.

[0498] 17B. The intraocular lens device of Embodiment 15B or Embodiment 16B, wherein the at least one loop or each of the plurality of loops has a substantially toroidal shape, and has a substantially square, rectangular, circular, oval, trapezoidal, or hexagonal cross-sectional shape.

[0499] 18B. The intraocular lens device of any one of Embodiments 1B-17B, wherein the at least one loop or each of the plurality of loops has a substantially elliptical, circular, or oval shape, and has a substantially square, rectangular, circular, oval, trapezoidal, or hexagonal cross-sectional shape.

[0500] 19B. The intraocular lens device of any one of Embodiments 1B-18B, wherein the at least one loop or each of the plurality of loops has a substantially square, rectangular, or trapezoidal shape, and has a substantially square, rectangular, circular, oval, trapezoidal, or hexagonal cross-sectional shape.

[0501] 20B. The intraocular lens device of any one of Embodiments 1B-19B, wherein at least one loop of the plurality of loops has a tapered profile such that a posterior portion of the at least one loop has a width that is less than an anterior portion of the at least one loop;optionally wherein each of the plurality of loops has a tapered profile such that each loop of the plurality of loops has a posterior portion has a width that is less than an anterior portion of said respective loop.

[0502] 21B. The intraocular lens device of any one of Embodiments 1B-20B, wherein each loop of the plurality of loops both extends from a unique portion and returns to that same unique portion.

[0503] 22B. The intraocular lens device of any one of Embodiments 1B-21B, wherein each loop of the plurality of loops is attached from a unique portion along the intraocular ring.

[0504] 23B. The intraocular lens device of any one of Embodiments 1B-20B, wherein each loop of the plurality of loops has two attachment points with the intraocular ring; optionally sharing both attachment points with both adjacent neighboring loops.

[0505] 24B. The intraocular lens device of any one of Embodiments 1B-23B, wherein an arch, truss, lattice, mesh, and / or rod extends between two or more loops of the plurality of loops for increased stability.

[0506] 25B. In an Embodiment, an intraocular lens device, comprising: i) an intraocular ring that is radially centered along an optical axis; ii) a plurality of haptics extending from the intraocular ring; and iii) a plurality of nodes arranged around the intraocular ring;

[0507] wherein the intraocular ring comprises a continuous recess, a plurality of perforations, or a plurality of slits, or combinations thereof, along a circumference of the intraocular ring.

[0508] 26B. The intraocular lens device of Embodiment 24B, wherein the intraocular ring comprises an annular body portion comprising: i) an anterior surface; ii) a posterior surface: and iii) a sidewall extending substantially parallel to the optical axis between the anterior surface and the posterior surface, wherein the sidewall has an interior surface and an exterior surface proximal and distal from said optical axis, respectively.

[0509] 27B. The intraocular lens device of Embodiment 25B or Embodiment 26B, wherein the intraocular ring comprises the continuous recess along the circumference of the intraocular ring.

[0510] 28B. The intraocular lens device of any one of Embodiments 25B-27B, wherein the continuous recess is along the sidewall.

[0511] 29B. The intraocular lens device of any one of Embodiments 25B-28B, wherein the continuous recess is along a median portion of the exterior surface of the sidewall.

[0512] 30B. The intraocular lens device of any one of Embodiments 25B-29B, wherein the continuous recess along the sidewall comprises a cutout of a portion of the exterior surface of the sidewall.

[0513] 3 IB. The intraocular lens device of Embodiment 30B, wherein the cutout portion extends about 15% to no more than about 80% into the sidewall towards the interior surface of said sidewall; optionally extends about 25-80%, about 35-80%, about 45-80%, about 55- 80%, about 65-80%, about 20-70%, about 30-70%, about 40-70%, about 50-70%, about 60- 70%, about 30-60%, about 40-60%, about 50-60%, or about 40-50% into the sidewall towards the interior surface of said sidewall.

[0514] 32B. The intraocular lens device of Embodiment 30B or Embodiment 3 IB, wherein the cutout portion extends between the anterior surface and the posterior surface of about 15% to no more than about 50% along the median portion of the exterior surface of said sidewall; optionally extends between the anterior surface and the posterior surface of about 15-50%, about 15-45%, about 15-40%, about 15-35%, about 15-30%, about 15-25%, about 20-45%, about 25-35%, about 25-50%, or about 30-45% along the median portion of the exterior surface of said sidewall.

[0515] 33B. The intraocular lens device of any one of Embodiments 26B-32B, wherein the annular body portion of the intraocular ring has a substantially toroidal shape.

[0516] 34B. The intraocular lens device of Embodiment 33B, wherein the substantially toroidal shaped annular body portion has a substantially square cross-sectional shape or a substantially rectangular cross-sectional shape.

[0517] 35B. The intraocular lens device of any one of Embodiments 25B-34B, wherein the intraocular ring comprises the plurality of perforations along the circumference of the intraocular ring.

[0518] 36B. The intraocular lens device of Embodiment 35B, wherein the plurality of perforations is along a median portion of the exterior surface of the sidewall.

[0519] 37B. The intraocular lens device of Embodiment 35B or Embodiment 36B, wherein a plurality or each of the plurality of perforations extend through the sidewall.

[0520] 38B. The intraocular lens device of any one of Embodiments 35B-37B, wherein a plurality or each of the plurality of perforations extend between the anterior surface and the posterior surface of about 15% to no more than about 50% along the median portion of the exterior surface of said sidewall; optionally extend between the anterior surface and theposterior surface of about 15-50%, about 15-45%, about 15-40%, about 15-35%, about 15- 30%, about 15-25%, about 20-45%, about 25-35%, about 25-50%, or about 30-45% along the median portion of the exterior surface of said sidewall.

[0521] 39B. The intraocular lens device of any one of Embodiments 25B-38B, wherein the intraocular ring comprises the plurality of slits along the circumference of the intraocular ring.

[0522] 40B. The intraocular lens device of Embodiment 39B, wherein the plurality of slits is along a median portion of the exterior surface of the sidewall.

[0523] 41B. The intraocular lens device of Embodiment 39B or Embodiment 40B, wherein a plurality or each of the plurality of slits extend through the sidewall.

[0524] 42B. The intraocular lens device of any one of Embodiments 39B-41B, wherein a plurality or each of the plurality of slits extend between the anterior surface and the posterior surface of about 15% to no more than about 50% along the median portion of the exterior surface of said sidewall; optionally extend between the anterior surface and the posterior surface of about 15-50%, about 15-45%, about 15-40%, about 15-35%, about 15-30%, about 15-25%, about 20-45%, about 25-35%, about 25-50%, or about 30-45% along the median portion of the exterior surface of said sidewall.

[0525] 43B. The intraocular lens device of any one of Embodiments 39B-42B, wherein a plurality or each of the plurality of slits extend about 15 degrees to no more than about 45 degrees radially about the optical axis and along the median portion of the exterior surface of said sidewall.

[0526] 44B. The intraocular lens device of any one of Embodiments 39B-43B, wherein the plurality of slits comprises 2, 3, or 4 slits along a median portion of the exterior surface of the sidewall.

[0527] 45B. The intraocular lens device of any one of Embodiments 25B-44B, wherein the intraocular ring comprises a combination of the continuous recess, the plurality of perforations, and the plurality of slits along the circumference of the intraocular ring.

[0528] 46B. The intraocular lens device of any one of Embodiments 25B-45B, wherein the intraocular ring comprises the continuous recess and the plurality of perforations along the circumference of the intraocular ring.

[0529] 47B. The intraocular lens device of any one of Embodiments 25B-45B, wherein the intraocular ring comprises the continuous recess and the plurality of slits along the circumference of the intraocular ring.

[0530] 48B. The intraocular lens device of any one of Embodiments 25B-45B, whereinthe intraocular ring comprises the plurality of perforations and the plurality of slits along the circumference of the intraocular ring.

[0531] 49B. The intraocular lens device of any one of Embodiments 25B-45B, wherein the intraocular ring comprises the continuous recess, the plurality of perforations, and the plurality of slits along the circumference of the intraocular ring.

[0532] 50B. The intraocular lens device of any one of Embodiments 25B-49B, wherein the continuous recess, the plurality of perforations, and / or the plurality of slits are suitable for dividing a portion of the sidewall along the median portion of the intraocular ring; optionally wherein the continuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring creates at least one line of weakness dividing at least one portion of the intraocular ring.

[0533] 5 IB. The intraocular lens device of Embodiment 50B, wherein the intraocular ring comprises one or more divided portions of the sidewall along the median portion of said intraocular ring.

[0534] 52B. The intraocular lens device of Embodiment 5 IB, wherein a divided portion of the one or more divided portions of the sidewall along the median portion of said intraocular ring are suitable for insertion of a haptic of an intraocular lens (IOL).

[0535] 53B. The intraocular lens device of Embodiment 52B, wherein each divided portion of the one or more divided portions of the sidewall along the median portion of said intraocular ring are suitable for insertion of a haptic of an intraocular lens (IOL).

[0536] 54B. The intraocular lens device of any one of Embodiments 1B-53B, wherein the intraocular ring is sufficiently large to permit the insertion of an IOL; optionally wherein the intraocular ring has an internal diameter that is about 0.1 mm to about 1.0 mm greater than an optic diameter of an IOL, such as about 0.1 mm, about 0.2 mm, about 0.25 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.75 mm, about 0.8 mm, about 0.9 mm, or about 1.0 mm, greater than an optic diameter of an IOL.

[0537] 55B. The intraocular lens device of any one of Embodiments 1B-54B, wherein the intraocular ring is sufficiently large to permit the insertion of an IOL with an optical diameter in the range of between about 4.0-8.0 mm; optionally about 6.0 mm.

[0538] 56B. The intraocular lens device of any one of Embodiments 1B-55B, wherein the intraocular ring has an internal diameter of 6.25 mm to 8.0 mm; optionally an internal diameter of 7.5 mm.

[0539] 57B. The intraocular lens device of any one of Embodiments 1B-56B, wherein the intraocular ring has an outermost diameter in the range of between about 5-10 mm.

[0540] 58B. The intraocular lens device of Embodiment 57B, wherein the outermost diameter is in the range of between about 5-6 mm, about 5-7 mm, about 5-8 mm, about 5-9 mm, about 5.0-10 mm, about 6-7 mm, about 6-8 mm, about 6-9 mm, about 6-10 mm, about 7-8 mm, about 7-9 mm, about 7-10 mm, about 8-9 mm, about 8-10 mm, about 9-10 mm, about 5-10 mm, about 6-6.5 mm, about 6-7 mm, about 6-7.5 mm, about 6-8 mm, about 6.25-7 mm, about 6.25-7.25 mm, about 6.5-7 mm, about 6.5-7.25 mm, about 6.5-7.5 mm, about 6.75-7.25 mm, about 7-7.5 mm, about 7-8 mm, about 7.25-8 mm, about 7.25-7.75 mm, or about 7.5-8 mm.

[0541] 59B. The intraocular lens device of Embodiment 57B or Embodiment 58B, wherein the outermost diameter of the intraocular ring is about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 5.25 mm, about 5.5 mm, about 5.75 mm, about 6.25 mm, about 6.5 mm, about 6.75 mm, about 7.25 mm, about 7.5 mm, about 7.75, about 8.25 mm, about 8.5 mm, about 8.75 mm, about 9.25 mm, or about 9.5 mm.

[0542] 60B. The intraocular lens device of any one of Embodiments 25B-59B, wherein the plurality of nodes is arranged in a symmetrical pattern around the intraocular ring.

[0543] 61B. The intraocular lens device of any one of Embodiments 25B-60B, wherein each of the plurality of nodes is arranged about 15-45 degrees from adjacent nodes along the intraocular ring; optionally wherein the plurality of nodes is arranged about 15-30, 20-40, 25- 45, or 30-45 degrees around the intraocular ring, such as about 15, 20, 25, 30, 35, 40, or 45 degrees around the intraocular ring.

[0544] 62B. The intraocular lens device of any one of Embodiments 25B-60B, wherein the plurality of nodes is arranged about 15-45 degrees around the intraocular ring; optionally wherein the plurality of nodes is arranged about 15-30, 20-40, 25-45, or 30-45 degrees around the intraocular ring, such as about 15, 20, 25, 30, 35, 40, or 45 degrees around the intraocular ring.

[0545] 63B. The intraocular lens device of any one of Embodiments 25B-62B, wherein the plurality of nodes is arranged along the anterior surface of the intraocular ring.

[0546] 64B. The intraocular lens device of any one of Embodiments 25B-62B, wherein the plurality of nodes is arranged along the posterior surface of the intraocular ring.

[0547] 65B. The intraocular lens device of any one of Embodiments 25B-62B, wherein the plurality of nodes is arranged along the anterior and posterior surfaces of the intraocular ring.

[0548] 66B. The intraocular lens device of any one of Embodiments 1B-65B, wherein the device is configured to be inserted in a capsular bag of an eye; optionally the devicecomprises an anti-lens epithelial cell proliferation coating and / or is made of a material which allows removal of proliferating cells.

[0549] 67B. The intraocular lens device of any one of Embodiments 1B-66B, wherein the device is configured to be inserted in a capsular bag of an eye after removal of a lens.

[0550] 68B. The intraocular lens device of any one of Embodiments 1B-67B, wherein the device is sized and shaped for implantation into a capsular bag of an eye.

[0551] 69B. The intraocular lens device of any one of Embodiments 1B-65B, wherein the device is configured to be inserted in an eye lacking a capsular bag.

[0552] 70B. The intraocular lens device of any one of Embodiments 1B-69B, wherein the device is sized and scaled to accommodate a size of an eye.

[0553] 71B. The intraocular lens device of any one of Embodiments 1B-70B, wherein the device is a single-molded design.

[0554] 72B. The intraocular lens device of any one of Embodiments 1B-71B, wherein the device is molded from a single piece of material.

[0555] 73B. The intraocular lens device of any one of Embodiments 1B-72B, wherein the device is flexible; optionally wherein the device is flexible enough to be loaded into a cartridge for implantation.

[0556] 74B. The intraocular lens device of any one of Embodiments 1B-73B, wherein the device is collapsible, compressible and / or foldable; optionally wherein the device is collapsible, compressible and / or foldable enough to be loaded into a cartridge for implantation.

[0557] 75B. The intraocular lens device of any one of Embodiments 1B-74B, wherein the device is collapsible, compressible and / or foldable; optionally wherein the device is collapsible, compressible and / or foldable enough to be insertable using a pair of forceps or other grasping instrument, and / or injectable by a needle and / or a cartridge; optionally injectable by a cartridge with a width of about 2.4 mm.

[0558] 76B. The intraocular lens device of any one of Embodiments 1B-75B, wherein the device is deformable for insertion into a capsular bag of an eye; optionally wherein the device is deformable enough to be loaded into a cartridge for implantation.

[0559] 77B. The intraocular lens device of any one of Embodiments 1B-76B, wherein the device is self-expandable upon insertion into a capsular bag of an eye.

[0560] 78B. The intraocular lens device of any one of Embodiments 1B-77B, wherein the device is a prosthetic capsular device.

[0561] 79B. The intraocular lens device of any one of Embodiments 1B-78B, whereinthe device comprises a biocompatible, compressible, flexible, elastic, hydrophobic, and / or hydrophilic material; optionally wherein the device comprises poly(methyl-methacrylate) (PMMA), hydrophilic acrylic or hydrophobic acrylic, hydrophilic silicone or hydrophobic silicone, polycarbonate, polypropylene, polystyrene, polyethylene, noryl, polysulfone, acetal, acrylonitrile butadiene styrene, PC-ABS alloy, nylon, nylon 6, nylon 6,6, nylon 11, nylon 12, thermoplastic elastomer, thermoplastic polyurethane, thermoplastic vulcanizate, coloring agents, talc, stiffening agents, glass fibre, and / or antimicrobial agents.

[0562] 80B. The intraocular lens device of any one of Embodiments 1B-79B, wherein the intraocular ring has radial symmetry.

[0563] 8 IB. The intraocular lens device of any one of Embodiments 1B-80B, wherein the intraocular ring has a substantially toroidal shape.

[0564] 82B. The intraocular lens device of any one of Embodiments 1B-81B, wherein the intraocular ring is bilaterally symmetrical across a plane perpendicular to the optical axis.

[0565] 83B. The intraocular lens device of any one of Embodiments 1B-82B, wherein the intraocular ring is bilaterally symmetrical across a plane dividing anterior and posterior portions of the intraocular ring.

[0566] 84B. The intraocular lens device of any one of Embodiments 1B-83B, wherein the intraocular ring is bilaterally symmetrical across a plane parallel to anterior and posterior portions of the intraocular ring.

[0567] 85B. The intraocular lens device of any one of Embodiments 1B-84B, wherein the intraocular ring has a smooth, continuous surface.

[0568] 86B. The intraocular lens device of any one of Embodiments 1B-85B, wherein the intraocular ring has a non-porous surface.

[0569] 87B. The intraocular lens device of any one of Embodiments 1B-86B, wherein the height of the intraocular ring along the optical axis is in the range of between about 0.5-3.5 mm.

[0570] 88B. The intraocular lens device of Embodiment 87B, wherein the height of the intraocular ring along the optical axis is in the range of between about 0.5-1.0 mm, about 0.5-1.5 mm, about 0.5-2.0 mm, about 0.5-2.5 mm, about 0.5-3.0 mm, about 0.5-3.5 mm, about 1.0-1.5 mm, about 1.0-2.0 mm, about 1.0-2.5 mm, about 1.0-3.0 mm, about 1.0-3.5 mm, about 1.5-2.0 mm, about 1.5-2.5 mm, about 2.0-2.5 mm, about 2.5-3.0 mm, about 2.5-3.5 mm, or about 3.0-3.5 mm.

[0571] 89B. The intraocular lens device of Embodiment 87B or Embodiment 88B, wherein the height of the intraocular ring along the optical axis is about 0.5 mm, about 0.6mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, or about 3.5 mm.

[0572] 90B. The intraocular lens device of any one of Embodiments 25B-89B, wherein the continuous recess, the plurality of perforations, and / or the plurality of slits along the circumference of the intraocular ring have a height along the optical axis is in the range of between about 0.1-0.5 mm, about 0.1-0.2 mm, about 0.15-0.4 mm, about 0.15-0.3 mm, about 0.15-0.25 mm, about 0.2-0.5 mm, or about 0.2-0.3 mm, such as about 0.1 mm, about 0.15 mm, about 0.2 mm, about 0.25 mm, about 0.3 mm, about 0.4 mm, or about 0.5 mm.

[0573] 91B. The intraocular lens device of any one of Embodiments 1B-90B, wherein the plurality of loops protrudes tangentially beyond a diameter of the intraocular ring.

[0574] 92B. The intraocular lens device of any one of Embodiments 1B-91B, wherein the intraocular ring has a thickness sufficient to provide adequate stiffness to maintain its shape upon insertion in the capsular bag.

[0575] 93B. The intraocular lens device of any one of Embodiments 1B-92B, wherein the intraocular ring and / or a loop of the plurality of loops has a thickness in the range of between about 0.01-1.5 mm.

[0576] 94B. The intraocular lens device of Embodiment 93B, wherein the intraocular ring and / or a loop of the plurality of loops has a thickness in the range of between about 0.01- 0.05 mm, about 0.01-0.1 mm, about 0.01-0.5 mm, about 0.01-1.0 mm, about 0.01-1.5 mm, about 0.05-0.1 mm, about 0.05-0.5 mm, about 0.05-1.0 mm, about 0.05-1.5 mm, about 0.1- 0.5 mm, about 0.1-1.0 mm, about 0.1-1.5 mm, about 0.5-1.0 mm, about 0.5-1.5 mm, or about 1.0-1.5 mm.

[0577] 95B. The intraocular lens device of Embodiment 93B or Embodiment 94B, wherein the intraocular ring and / or a loop of the plurality of loops has a thickness of about 0.01 mm, about 0.02 mm, about 0.03 mm, about 0.04 mm, about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, or about 1.5 mm.

[0578] 96B. The intraocular lens device of any one of Embodiments 1B-95B, wherein the intraocular ring has an interior surface and an outer surface.

[0579] 97B. The intraocular lens device of any one of Embodiments 1B-96B, whereinthe interior surface of the intraocular ring comprises a ridge.

[0580] 98B. The intraocular lens device of Embodiment 97B, wherein the ridge is configured for securing and / or retaining an intraocular lens.

[0581] 99B. The intraocular lens device of any one of Embodiments 1B-98B, wherein the intraocular ring comprises an internal cavity.

[0582] 100B. The intraocular lens device of Embodiment 99B, wherein the internal cavity of the intraocular ring has a volume in the range of about 0.5-100 mm3.

[0583] 101B. The intraocular lens device of any one of Embodiments 1B-100B, wherein the intraocular ring has a size that is substantially smaller than the size of a capsular bag.

[0584] 102B. The intraocular lens device of any one of Embodiments 1B-101B, wherein the intraocular ring has a size that is 10-50% smaller than the size of a capsular bag.

[0585] 103B. The intraocular lens device of any one of Embodiments 1B-102B, wherein the size of the intraocular ring minimizes anterior, posterior, and / or radial protrusion of the intraocular ring into the capsular bag.

[0586] 104B. The intraocular lens device of any one of Embodiments 1B-103B, wherein the shape of the intraocular ring minimizes anterior, posterior, and / or radial protrusion of the intraocular ring into the capsular bag.

[0587] 105B. The intraocular lens device of any one of Embodiments 1B-104B, wherein at least one haptic of the plurality of haptics extends at an angle in the range of between 30 degrees below and 30 degrees above the plane of the intraocular ring.

[0588] 106B. The intraocular lens device of any one of Embodiments 1B-105B, wherein each haptic of the plurality of haptics extends at an angle in the range of between 30 degrees below and 30 degrees above the plane of the intraocular ring.

[0589] 107B. The intraocular lens device of any one of Embodiments 1B-106B, wherein each haptic of the plurality of haptics extends at an angle in the range of between 20 degrees below and 20 degrees above the plane of the intraocular ring.

[0590] 108B. The intraocular lens device of any one of Embodiments 1B-106B, wherein the plurality of haptics extend at an angle in the range of between 30 degrees below and 30 degrees above the plane of the intraocular ring.

[0591] 109B. The intraocular lens device of any one of Embodiments 1B-108B, wherein the plurality of haptics extends in a posterior direction

[0592] 110B. The intraocular lens device of Embodiment 109B, wherein the degree of posteriorly-directed angulation of the plurality of haptics is between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees belowthe plane of the intraocular ring.

[0593] 11 IB. The intraocular lens device of Embodiment 109B or Embodiment HOB, wherein the degree of posteriorly-directed angulation of the plurality of haptics is about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 degrees below the plane of the intraocular ring.

[0594] 112B. The intraocular lens device of any one of Embodiments 109B-11 IB, wherein the degree of posteriorly-directed angulation of the plurality of haptics is 10 degrees below the plane of the intraocular ring.

[0595] 113B. The intraocular lens device of any one of Embodiments IB-112B, wherein at least one haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below the plane of the intraocular ring.

[0596] 114B. The intraocular lens device of any one of Embodiments IB-113B, wherein each haptic of the plurality of haptics extends at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below the plane of the intraocular ring.

[0597] 115B. The intraocular lens device of any one of Embodiments IB-114B, wherein the plurality of haptics extend at an angle in the range of between about 5-25 degrees, about 5-20 degrees, about 5-15 degrees, about 7-20 degrees, or about 12-25 degrees below the plane of the intraocular ring.

[0598] 116B. The intraocular lens device of any one of Embodiments 1B-105B, wherein the plurality of haptics extends in a direction substantially parallel to the plane of the intraocular ring.

[0599] 117B. The intraocular lens device of any one of Embodiments 1B-105B orEmbodiment 116B, wherein the plurality of haptics extends in a direction substantially parallel to a plane perpendicular to the optical axis.

[0600] 118B. The intraocular lens device of any one of Embodiments IB-117B, wherein the plurality of haptics are configured to be substantially rotationally symmetric with respect to the optical axis.

[0601] 119B. The intraocular lens device of any one of Embodiments IB-118B, wherein the plurality of haptics are configured to be substantially radially symmetric with respect to the optical axis.

[0602] 120B. The intraocular lens device of any one of Embodiments IB-119B, wherein the plurality of haptics comprises 2-6 haptics.

[0603] 121B. The intraocular lens device of any one of Embodiments 1B-120B, wherein the plurality of haptics comprises 2, 3, 4, 5, or 6 haptics.

[0604] 122B. The intraocular lens device of any one of Embodiments 1B-121B, wherein the plurality of haptics comprises of two diametrically opposed haptics.

[0605] 123B. The intraocular lens device of any one of Embodiments 1B-121B, wherein the plurality of haptics comprises of three trigonally positioned haptics.

[0606] 124B. The intraocular lens device of any one of Embodiments 1B-121B, wherein the plurality of haptics comprises of four equally spaced haptics.

[0607] 125B. The intraocular lens device of any one of Embodiments 1B-124B, wherein the plurality of haptics are flexible.

[0608] 126B. The intraocular lens device of any one of Embodiments 1B-125B, wherein the plurality of haptics are collapsible.

[0609] 127B. The intraocular lens device of any one of Embodiments 1B-126B, wherein the plurality of haptics are deformable; optionally wherein the plurality of haptics are deformable for insertion into a capsular bag of an eye.

[0610] 128B. The intraocular lens device of any one of Embodiments 1B-127B, wherein the plurality of haptics are self-expandable; optionally wherein the plurality of haptics are self-expandable upon insertion into a capsular bag of an eye.

[0611] 129B. The intraocular lens device of any one of Embodiments 1B-128B, wherein at least one haptic or each of the plurality of haptics has a wire shape.

[0612] 130B. The intraocular lens device of any one of Embodiments 1B-129B, wherein at least one haptic or each of the plurality of haptics has a boomerang wire shape.

[0613] 13 IB. The intraocular lens device of any one of Embodiments 1B-130B, wherein at least one haptic or each of the plurality of haptics has an arcing wire shape.

[0614] 132B. The intraocular lens device of any one of Embodiments 1B-131B, wherein at least one haptic or each of the plurality of haptics has a thin, cylindrical wire shape.

[0615] 133B. The intraocular lens device of any one of Embodiments 1B-132B, wherein at least one haptic or each of the plurality of haptics has a petal-like shape.

[0616] 134B. The intraocular lens device of any one of Embodiments 1B-133B, wherein at least one haptic or each of the plurality of haptics comprises a first substantially linear portion, an arcuate portion, and a second substantially linear portion.

[0617] 135B. The intraocular lens device of any one of Embodiments 1B-134B, wherein at least one haptic or each of the plurality of haptics has a point of peak convexity.

[0618] 136B. The intraocular lens device of any one of Embodiments 1B-135B, whereinat least one haptic or each of the plurality of haptics comprises a parabolic arc.

[0619] 137B. The intraocular lens device of any one of Embodiments 1B-136B, wherein at least one haptic or each of the plurality of haptics extend radially from the intraocular ring and then curve back towards the intraocular ring.

[0620] 138B. The intraocular lens device of any one of Embodiments 1B-137B, wherein each of the plurality of haptics has a cross-sectional diameter between about 0.001-1.5 mm.

[0621] 139B. The intraocular lens device of Embodiment 138B, wherein each of the plurality of haptics has a cross-sectional diameter between about 0.001-0.01 mm, about 0.001-0.1 mm, about 0.01-1.0 mm, about 0.1-1.0 mm, about 0.1-0.5 mm, about 0.5-1.5 mm, about 0.5- 1.0 mm, or about 1.0-1.5 mm.

[0622] 140B. The intraocular lens device of Embodiment 138B or Embodiment 139B, wherein each of the plurality of haptics has a cross-sectional diameter of about 0.01 mm, about 0.05 mm, about 0.06 mm, about 0.07 mm, about 0.08 mm, about 0.09 mm, about 0.1 mm, about 0.11 mm, about 0.12 mm, about 0.13 mm, about 0.14 mm, about 0.15 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, or about 1.5 mm.

[0623] 141B. The intraocular lens device of any one of Embodiments 1B-140B, wherein at least one haptic or each of the plurality of haptics has a pathlength in the range of between about 10-16 mm.

[0624] 142B. The intraocular lens device of Embodiment 141B, wherein at least one haptic or each of the plurality of haptics has a pathlength in the range of between about 10-12 mm, about 10-12 mm, about 10-13 mm, about 12-13 mm, about 12-14 mm, about 13-14 mm, about 13-15 mm, about 14-15 mm, about 14-16 mm, or about 15-16 mm.

[0625] 143B. The intraocular lens device of Embodiment 141B or Embodiment 142B, wherein at least one haptic or each of the plurality of haptics has a pathlength of about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0626] 144B. The intraocular lens device of any one of Embodiments 1B-143B, wherein a wingspan between two diametrically opposed haptics of the plurality of haptics comprises the distance between the points of peak convexity of each haptic.

[0627] 145B. The intraocular lens device of Embodiment 144B, wherein a configuration comprising two haptics has a wingspan that is in the range of between about 5.0-16 mm.

[0628] 146B. The intraocular lens device of Embodiment 144B or Embodiment 145B, wherein a configuration comprising two haptics has a wingspan that is in the range ofbetween about 5-8 mm, about 5-11 mm, about 5-14 mm, about 5-16, about 6-9 mm, about 6- 12 mm, about 6-15 mm, about 6-16 mm, about 7-10 mm, about 7-13 mm, about 7-16 mm, about 8-11 mm, about 8-14 mm, about 8-16 mm, about 9-12 mm, about 9-14 mm, about 9-16 mm, about 10-12 mm, about 10-14 mm, about 10-16 mm, about 11-13 mm, about 11-16 mm, about 12-14 mm, about 12-16 mm, about 13-15 mm, about 13-16 mm, about 14-15 mm, about 14-16 mm, or about 15-16 mm.

[0629] 147B. The intraocular lens device of any one of Embodiments 144B-146B, wherein a configuration comprising two haptics has a wingspan that is about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0630] 148B. The intraocular lens device of any one of Embodiments 1B-147B, wherein a single haptic has a curve at the point of peak convexity comprising a radius in the range of between about 3-15 mm.

[0631] 149B. The intraocular lens device of Embodiment 148B, wherein a single haptic has a curve at the point of peak convexity comprising a radius in the range of between about 3-4 mm, about 3-5 mm, about 4-5 mm, about 4-6 mm, about 5-6 mm, about 5-7 mm, about 6- 7 mm, about 6-8 mm, about 7-8 mm, about 7-9 mm, about 8-9 mm, about 8-10 mm, about 9- 10 mm, about 9-11 mm, about 10-11 mm, about 10-12 mm, about 11-12 mm, about 11-13 mm, about 12-13 mm, about 12-14 mm, about 13-14 mm, about 13-15 mm, or about 14-15 mm.

[0632] 150B. The intraocular lens device of Embodiment 148B or Embodiment 149B, wherein a single haptic has a curve at the point of peak convexity comprising a radius of about 3.0 mm, about 4.0 mm, about 5.0 mm, about 6.0 mm, about 7.0 mm, about 8.0 mm, about 9.0 mm, about 10 mm, about 11 mm, about 12 mm, about 13 mm, about 14 mm, about 15 mm, or about 16 mm.

[0633] 151B. The intraocular lens device of any one of Embodiments 1B-150B, wherein the plurality of haptics are suitable for pressing against the tissue of the sulcus of the eye upon implantation.

[0634] 152B. The intraocular lens device of any one of Embodiments 1B-151B, wherein the plurality of haptics are suitable for supporting the device within a capsular bag upon implantation in an eye.

[0635] 153B. The intraocular lens device of any one of Embodiments 1B-152B, wherein the device has a weight in the range of between about 2-250 mg.

[0636]

[0637] 154B. The intraocular lens device of Embodiment 153B, wherein the device has a weight in the range of between about 2-10 mg, about 2-15 mg, about 2-25 mg, about 2-35 mg, about 2-45 mg, about 2-55 mg, about 2-65 mg, about 2-70 mg about 10-15 mg, about 10- 20 mg, about 10-30 mg, about 10-40 mg, about 10-50 mg, about 10-60 mg, about 10-70 mg, about 15-25 mg, about 15-35 mg, about 15-45 mg, about 15-55 mg, about 15-65 mg, about 20-25 mg, about 25-30 mg, about 25-35 mg, about 30-35 mg, about 35-40 mg, about 35-45 mg, about 40-45 mg, about 45-50 mg, about 45-55 mg, about 50-55 mg, about 55-60 mg, about 55-65 mg, about 60-65 mg, about 60-70 mg, about 65-70 mg, about 2-100 mg, about 2- 125 mg, about 2-150 mg, about 2-175 mg, about 2-200 mg, about 2-225 mg, about 2-250 mg, about 50-100 mg, about 50-125 mg, about 50-150 mg, about 50-175 mg, about 50-200 mg, about 50-225 mg, about 50-250 mg, about 100-125 mg, about 100-150 mg, about 100-175 mg, about 100-200 mg, about 100-225 mg, about 100-250 mg, about 150-175 mg, about 150- 200 mg, about 150-225 mg, or about 150-250 mg.

[0638] 155B. The intraocular lens device of Embodiment 153 or Embodiment 154B, wherein the device has a weight of about 5.0 mg, about 10 mg, about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg, about 40 mg, about 45 mg, about 50 mg, about 55 mg, about 60 mg, about 65 mg, about 70 mg, about 100 mg, about 125 mg, about 150 mg, about 175 mg, about 200 mg, about 225 mg, or about 250 mg.

[0639] 156B. The intraocular lens device of any one of Embodiments 1B-155B, wherein the plurality of haptics are configured to support the weight of the device.

[0640] 157B. The intraocular lens device of any one of Embodiments 1B-156B, wherein each of the plurality of haptics extends smoothly from the intraocular ring.

[0641] 158B. The intraocular lens device of any one of Embodiments 1B-157B, wherein at least one haptic or each of the plurality of haptics has a smooth surface along the entire length of the haptic.

[0642] 159B. The intraocular lens device of any one of Embodiments 1B-158B, wherein the plurality of haptics are configured to be non-abrasive and / or non-irritating to the sulcus of an eye.

[0643] 160B. The intraocular lens device of any one of Embodiments 1B-159B, wherein the plurality of haptics are configured to be non-abrasive and / or non-irritating to the cornea of an eye.

[0644] 161B. The intraocular lens device of any one of Embodiments 1B-160B, wherein at least one haptic or each of the plurality of haptics comprises an eyelet for surgical suturing, optionally sufficient for allowing a 10-0 proline or vortex suture to pass through said eyelet.

[0645] 162B. The intraocular lens device of any one of Embodiments 1B-161B, wherein a single haptic of the plurality of haptics has a tensile strength in the range of between about 10-80 MPa.

[0646] 163B. The intraocular lens device of Embodiment 162B, wherein a single haptic of the plurality of haptics has a tensile strength in the range of between about 10-15 MPa, about 10-20 MPa, about 15-20 MPa, about 15-25 MPa, about 20-25 MPa, about 20-30 MPa, about 25-30 MPa, about 25-35 MPa, about 30-35 MPa, about 30-40 MPa, about 35-40 MPa, about 35-45 MPa, about 40-45 MPa, about 40-50 MPa, about 45-50 MPa, about 45-55 MPa, about 50-55 MPa, about 50-60 MPa, about 55-60 MPa, about 55-65 MPa, about 60-65 MPa, about 60-70 MPa, about 65-70 MPa, about 65-75 MPa, about 70-75 MPa, about 70-80 MPa, or about 75-80 MPa.

[0647] 164B. The intraocular lens device of Embodiment 162B or Embodiment 163B, wherein a single haptic of the plurality of haptics has a tensile strength of about 10 MPa, about 15 MPa, about 20 MPa, about 25 MPa, about 30 MPa, about 35 MPa, about 40 MPa, about 45 MPa, about 50 MPa, about 55 MPa, about 60 MPa, about 65 MPa, about 70 MPa, about 75 MPa, or about 80 MPa.

[0648] 165B. The intraocular lens device of any one of Embodiments 1B-164B, wherein a single haptic of the plurality of haptics has a stiffness in the range of between about 50-100 N / m2.

[0649] 166B. The intraocular lens device of Embodiment 165B, wherein a single haptic of the plurality of haptics has a stiffness in the range of between about 50-55 N / m2, about 50- 60 N / m2, about 55-60 N / m2, about 55-65 N / m2, about 60-65 N / m2, about 60-70 N / m2, about 65-70 N / m2, about 65-75 N / m2, about 70-75 N / m2, about 70-80 N / m2, about 75-80 N / m2, about 75-85 N / m2, about 80-85 N / m2, about 80-90 N / m2, about 85-90 N / m2, about 85-95 N / m2, about 90-95 N / m2, about 90-100 N / m2, or about 95-100 N / m2.

[0650] 167B. The intraocular lens device of Embodiment 165B or Embodiment 166B, wherein a single haptic of the plurality of haptics has a stiffness of about 50 N / m2, about 55 N / m2, about 60 N / m2, about 65 N / m2, about 70 N / m2, about 75 N / m2, about 80 N / m2, about 85 N / m2, about 90 N / m2, about 95 N / m2, or about 100 N / m2.

[0651] 168B. The intraocular lens device of any one of Embodiments 1B-167B, wherein the plurality of haptics support a weight in the range of between about 10-125 mg.

[0652] 169B. The intraocular lens device of Embodiment 168B, wherein the plurality of haptics support a weight in the range of between about 10-30 mg, about 10-50 mg, about 10- 70 mg, about 10-90 mg, about 10-110 mg, about 20-40 mg, about 20-60 mg, about 20-80 mg,about 20-100 mg, about 20-120 mg, about 30-50 mg, about 30-70 mg, about 30-90 mg, about 30-110 mg, about 40-60 mg, about 40-80 mg, about 40-100 mg, about 40-120 mg, about SO- 75 mg, about 50-95 mg, about 50-115 mg, about 50-125 mg, about 60-85 mg, about 60-105 mg, about 60-125 mg, about 75-95 mg, about 75-115 mg, about 75-125 mg, about 85-105 mg, about 80-125 mg, about 90-100 mg, about 90-110 mg, about 90-125 mg, about 100-115 mg, or about 100-125 mg.

[0653] 170B. The intraocular lens device of Embodiment 168B or Embodiment 269B, wherein the plurality of haptics support a weight of about 5.0 mg, about 10 mg, about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg, about 40 mg, about 45 mg, about 50 mg, about 55 mg, about 60 mg, about 65 mg, about 70 mg, about 75 mg, about 80 mg, about 85 mg, about 90 mg, about 95 mg, or about 100 mg.

[0654] 171B. The intraocular lens device of any one of Embodiments 1B-170B, wherein two diametrically opposed haptics allow radially-directed compression in the range of between about 1.0-15.0 mm, optionally about 5.0-10.0 mm.

[0655] 172B. The intraocular lens device of any one of Embodiments 1B-171B, wherein three trigonally positioned haptics allow radially-directed compression in the range of between about 3.0-15.0 mm, optionally about 3.0-8.0 mm.

[0656] 173B. The intraocular lens device of any one of Embodiments 1B-172B, wherein four equally spaced haptics allow radially-directly compression in the range of between about 1.0-15.0 mm, optionally about 1.0-6.0 mm.

[0657] 174B. The intraocular lens device of any one of Embodiments 1B-173B, wherein the intraocular ring comprises a rim having a squared edge, a rounded edge, or a tapered edge.

[0658] 175B. The intraocular lens device of any one of Embodiments 1B-174B, wherein the intraocular ring has at least one dimension sufficiently small to prevent the insertion of an IOL.

[0659] 176B. The intraocular lens device of any one of Embodiments 1B-175B, wherein the intraocular ring has at least one dimension sufficiently small to prevent an inserted IOL from falling into the vitreous upon implantation into the eye of a subject.

[0660] 177B. The intraocular lens device of any one of Embodiments 1B-176B, wherein the intraocular ring has at least one dimension sufficiently small to prevent the insertion of a collapsed, compressed and / or folded IOL.

[0661] 178B. The intraocular lens device of any one of Embodiments 1B-177B, wherein the intraocular ring is hydrophobic.

[0662] 179B. The intraocular lens device of any one of Embodiments 1B-178B, wherein the plurality of haptics is hydrophobic.

[0663] 180B. The intraocular lens device of any one of Embodiments 1B-179B, wherein the device is hydrophobic.

[0664] 181B. The intraocular lens device of any one of Embodiments 1B-180B, wherein the intraocular ring is hydrophilic.

[0665] 182B. The intraocular lens device of any one of Embodiments 1B-179B orEmbodiment 18 IB, wherein the plurality of haptics is hydrophilic.

[0666] 183B. The intraocular lens device of any one of Embodiments 1B-179B,Embodiment 18 IB or Embodiment 182B, wherein the device is hydrophilic.

[0667] 184B. The intraocular lens device of any one of Embodiments 1B-183B, wherein a collapsed, compressed and / or folded device has a length of about 8-15 mm; optionally a length of around 13 mm in length.

[0668] 185B. In an Embodiment, a intraocular lens system, comprising an intraocular lens (IOL) and the intraocular lens device of any one of Embodiments 1B-184B.

[0669] 186B. The intraocular lens system of Embodiment 185B, wherein the intraocular lens system has a diameter of less than about 2.2 mm when collapsed, compressed and / or folded.

[0670] 187B. The intraocular lens system of Embodiment 185B or Embodiment 186B, wherein the intraocular lens system has a length of about 10-15 mm when collapsed, compressed and / or folded.

[0671] 188B. The intraocular lens system of any one of Embodiments 185B-187B, wherein the IOL is hydrophobic.

[0672] 189B. The intraocular lens system of any one of Embodiments 185B-188B, wherein the IOL is hydrophilic.

[0673] 190B. The intraocular lens system of any one of Embodiments 185B-189B, wherein the optical diameter of the IOL is between about 4-15 mm.

[0674] 191B. The intraocular lens system of Embodiment 190B, wherein the optical diameter of the IOL is between about 4-6 mm, about 4-8 mm, about 4-10 mm, about 4-12 mm, about 6-8 mm, about 6-10 mm, about 6-12 mm, about 8-10 mm, about 8-12 mm, about 10-12 mm, about 10-15 mm, about 12-14 mm, about 12-15 mm, or about 14-15 mm.

[0675] 192B. The intraocular lens system of Embodiment 190B or Embodiment 191B, wherein the diameter of the IOL optic is about 4-8 mm; optionally 6-8 mm.

[0676] 193B. The intraocular lens system of any one of Embodiments 190B-192B,wherein there is no gap between the IOL and an interior surface of the intraocular ring.

[0677] 194B. The intraocular lens system of any one of Embodiments 190B-193B, wherein there is a gap between the IOL and an interior surface of the intraocular ring.

[0678] 195B. The intraocular lens system of Embodiment 194B, wherein the gap between the IOL and an interior surface of the intraocular ring is within a range of about 0.01 and about 1.0 mm; optionally within a range of about 0.15-0.75 mm or about 0.25-0.5 mm, such as about 0.1 mm, about 0.2 mm, about 0.25 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm.

[0679] 196B. The intraocular lens system of any one of Embodiments 190B-195B, wherein the intraocular lens device comprises 1, 2, or 3 IOLS.

[0680] 197B. The intraocular lens system of any one of Embodiments 190B-196B, wherein the intraocular lens device contains no more than 1 or 2 IOLs.

[0681] 198B. In an Embodiment, a method of implanting an intraocular lens (IOL) into the eye of a subject, comprising: i) injecting the intraocular lens device of any one of Embodiments 1B-197B into an eye of a subject; optionally into a capsular bag of an eye of a subject; and ii) injecting an intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

[0682] 199B. The method of Embodiment 198B, wherein the IOL is hydrophobic.

[0683] 200B. The method of Embodiment 198B, wherein the IOL is hydrophilic.

[0684] 201B. The method of any one of Embodiments 198B-200B, wherein the method further comprises injecting a second intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

[0685] 202B. The method of any one of Embodiments 198B-201B, wherein the method further comprises injecting a second intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

[0686] 203B. The method of any one of Embodiments 198B-202B, wherein the optical diameter of the IOL is between about 10-15 mm.

[0687] 204B. The method of any one of Embodiments 198B-203B, wherein the optical diameter of the IOL is between about 4-6 mm, about 4-8 mm, about 4-10 mm, about 4-12 mm, about 6-8 mm, about 6-10 mm, about 6-12 mm, about 8-10 mm, about 8-12 mm, about 10-12 mm, about 10-15 mm, about 12-14 mm, about 12-15 mm, or about...

Claims

What is claimed is:

1. An intraocular lens device, comprising: i) an annular body comprising: a) an anterior portion comprising an anterior opening radially centered along an optical axis; and b) a posterior portion comprising a posterior opening radially centered along the optical axis; wherein the anterior portion and the posterior portion meet at a plane substantially at the midpoint of the annular body between the anterior opening and the posterior opening; and ii) a plurality of haptics attached to the anterior portion.

2. An intraocular lens device, comprising: i) an annular body portion: a) an anterior portion comprising an anterior opening radially centered along an optical axis; b) a posterior portion comprising a posterior opening radially centered along the optical axis; and c) a lateral portion interposed between the anterior portion and the posterior portion, wherein the lateral portion protrudes radially beyond the anterior portion and the posterior portion; and ii) a plurality of haptics extending from the anterior portion of the annular body.

3. An intraocular lens device, comprising: i) an annular body portion: a) an anterior opening radially centered along an optical axis; b) a posterior opening radially centered along an optical axis; and c) a lateral portion extending from the anterior opening to the posterior opening, wherein the lateral portion protrudes radially beyond the anterior opening and the posterior opening; and ii) a plurality of haptics extending from an anterior portion of the lateral portion of the annular body.

4. An intraocular lens device, comprising: i) an annular body portion comprising an anterior portion comprising an anterior opening, a posterior portion comprising a posterior opening, and a lateral portion interposed between the anterior portion and the posterior portion; and ii) a plurality of haptics extending from the anterior portion of the annular body; wherein: a) the anterior opening and the posterior opening are radially centered along an optical axis, b) the anterior opening is larger than the posterior opening, and c) the lateral portion comprises a plurality of lateral openings perpendicular to the optical axis.

5. The intraocular lens device of any one of claims 1-4, wherein the annular body has radial symmetry; optionally wherein the annular body has a ring shape, a substantially prolate spheroid shape, a substantially ellipsoidal shape, or a substantially toroid shape.

6. The intraocular lens device of any one of claims 1-5, wherein the annular body extends from the anterior opening of the anterior portion to the posterior opening of the posterior portion.

7. The intraocular lens device of any one of claims 1-6, wherein the annular body has a mesh surface or wherein the annular body has a smooth surface, a smooth, continuous surface, and / or a non-porous surface.

8. The intraocular lens device of any one of claims 1-7, wherein the annular body further comprises a plurality of lateral openings.

9. The intraocular lens device of claim 8, wherein the plurality of lateral openings are substantially evenly spaced about a circumference of the annular body; optionally wherein the plurality of lateral openings are substantially evenly spaced about a circumference at the outermost diameter of the annular body.

10. The intraocular lens device of claim 8 or claim 9, wherein at least one lateral opening of the plurality of lateral openings has a height sufficient to accommodate a haptic of an IOL; optionally wherein each of the plurality of lateral openings has a height sufficient to accommodate a haptic of an IOL.

11. The intraocular lens device of any one of claims 1-10, wherein the annular body comprises an internal cavity.

12. The intraocular lens device of any one of claims 1-11, wherein the annular body has a size that is substantially smaller than the size of a capsular bag.

13. The intraocular lens device of any one of claims 1-12, wherein the device has a weight in the range of between about 5-250 mg.

14. The intraocular lens device of any one of claims 1-13, wherein the anterior opening has at least one dimension sufficiently large to permit the insertion of an IOL.

15. The intraocular lens device of any one of claims 1-14, wherein the posterior portion overlaps a portion of the anterior opening; optionally wherein the posterior portion radially overlaps 5-50% of the anterior opening.

16. The intraocular lens device of any one of claims 1-15, wherein the anterior opening is larger than the posterior opening.

17. The intraocular lens device of any one of claims 1-16, wherein the posterior opening has at least one dimension sufficiently small to prevent (i) the insertion of an IOL, (ii) an inserted IOL from falling into the vitreous upon implantation into the eye of a subject, and / or (iii) the insertion of a collapsed, compressed and / or folded IOL.

18. The intraocular lens device of any one of claims 1-17, wherein the posterior opening has a smaller dimension than the anterior opening.

19. The intraocular lens device of any one of claims 1-18, wherein the anterior portion comprises a gutter, track, well, or reservoir is proximal to the anterior opening;optionally wherein the gutter, track, well, or reservoir has a volume capacity of about 9 microliters.

20. An intraocular lens device, comprising: i) an intraocular ring that is radially centered along an optical axis; ii) a plurality of haptics extending from the intraocular ring; and iii) a plurality of loops extending from the intraocular ring and substantially perpendicular to the optical axis.

21. The intraocular lens device of claim 20, wherein each of the plurality of loops extend anteriorly from the intraocular ring relative to a plane of the intraocular ring.

22. The intraocular lens device of claim 20, wherein each of the plurality of loops extend posteriorly from the intraocular ring relative to a plane of the intraocular ring.

23. The intraocular lens device of any one of claims 20-22, wherein the intraocular ring comprises a substantially toroidal body portion.

24. The intraocular lens device of any one of claims 20-23, wherein the plurality of loops comprises 2-4, 2-6, or 2-8 loops; optionally wherein the plurality of loops are substantially evenly spaced about a circumference of the intraocular ring.

25. The intraocular lens device of any one of claims 20-24, wherein the plurality of loops are positioned perpendicularly, substantially perpendicularly, and / or obliquely to the optical axis.

26. The intraocular lens device of any one of claims 20-25, wherein at least one loop or each of the plurality of loops has a height sufficient to accommodate a haptic of an IOL.

27. The intraocular lens device of any one of claims 20-26, wherein at least one loop or each of the plurality of loops has a substantially toroidal shape, a substantially tubular shape, a substantially square shape, a substantially rectangular shape, a substantially elliptical shape, a substantially circular shape, a substantially oval shape, asubstantially trapezoidal shape, or a substantially hexagonal shape, or combinations thereof.

28. An intraocular lens device, comprising: i) an intraocular ring that is radially centered along an optical axis; ii) a plurality of haptics extending from the intraocular ring; and iii) a plurality of nodes arranged around the intraocular ring; wherein the intraocular ring comprises a continuous recess, a plurality of perforations, or a plurality of slits, or combinations thereof, along a circumference of the intraocular ring.

29. The intraocular lens device of claim 28, wherein the intraocular ring comprises an annular body portion comprising: i) an anterior surface; ii) a posterior surface: and iii) a sidewall extending substantially parallel to the optical axis between the anterior surface and the posterior surface, wherein the sidewall has an interior surface and an exterior surface proximal and distal from said optical axis, respectively.

30. The intraocular lens device of claim 28 or claim 29, wherein the annular body portion of the intraocular ring has a substantially toroidal shape.

31. The intraocular lens device of any one of claims 28-30, wherein the intraocular ring comprises the continuous recess along the circumference of the intraocular ring; optionally wherein the continuous recess is along the sidewall; optionally wherein the continuous recess is along a median portion of the exterior surface of the sidewall.

32. The intraocular lens device of any one of claims 28-30, wherein the intraocular ring comprises the plurality of perforations along the circumference of the intraocular ring; optionally wherein the plurality of perforations is along a median portion of the exterior surface of the sidewall; optionally wherein a plurality or each of the plurality of perforations extend through the sidewall.

33. The intraocular lens device of any one of claims 28-30, wherein the intraocular ring comprises the plurality of slits along the circumference of the intraocular ring; optionally wherein the plurality of slits is along a median portion of the exterior surface of the sidewall; optionally wherein a plurality or each of the plurality of slits extend through the sidewall.

34. The intraocular lens device of any one of claims 28-33, wherein the continuous recess, the plurality of perforations, and / or the plurality of slits are suitable for dividing a portion of the sidewall along the median portion of the intraocular ring; optionally wherein the continuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring creates at least one line of weakness dividing at least one portion of the intraocular ring.

35. The intraocular lens device of claim 34, wherein the intraocular ring comprises one or more divided portions of the sidewall along the median portion of said intraocular ring.

36. The intraocular lens device of claim 35, wherein a divided portion of the one or more divided portions of the sidewall along the median portion of said intraocular ring are suitable for insertion of a haptic of an intraocular lens (IOL).

37. The intraocular lens device of any one of claims 28-36, wherein the plurality of nodes is arranged in a symmetrical pattern around the intraocular ring.

38. The intraocular lens device of any one of claims 20-37, wherein the intraocular ring is sufficiently large to permit the insertion of an IOL; optionally wherein the intraocular ring has an internal diameter that is about 0.1 mm to about 1.0 mm greater than an optic diameter of an IOL, such as about 0.1 mm, about 0.2 mm, about 0.25 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.75 mm, about 0.8 mm, about 0.9 mm, or about 1.0 mm, greater than an optic diameter of an IOL.

39. The intraocular lens device of any one of claims 20-38, wherein the intraocular ring has radial symmetry; optionally wherein the intraocular ring has a substantially toroidal shape.

40. The intraocular lens device of any one of claims 20-39, wherein the device has a weight in the range of between about 2-250 mg.

41. The intraocular lens device of any one of claims 1-40, wherein the plurality of haptics are arranged around the anterior portion; optionally wherein the plurality of haptics are arranged in a symmetrical pattern around the anterior portion.

42. The intraocular lens device of any one of claims 1-41, wherein the plurality of haptics extend beyond the outermost perimeter of the annular body.

43. The intraocular lens device of any one of claims 1-42, wherein at least one haptic of the plurality of haptics extends at an angle in the range of between 30 degrees below and 30 degrees above a plane where the at least one haptic of the plurality of haptics originates from the anterior portion of the annular body; optionally wherein each haptic of the plurality of haptics extends at an angle in the range of between 30 degrees below and 30 degrees above a plane where the respective haptic of the plurality of haptics originates from the anterior portion of the annular body.

44. The intraocular lens device of any one of claims 1-43, wherein each of the plurality of haptics originates on substantially a single plane.

45. The intraocular lens device of any one of claims 1-44, wherein the plurality of haptics are configured to be substantially rotationally symmetric with respect to the optical axis.

46. The intraocular lens device of any one of claims 1-45, wherein the plurality of haptics comprises 2-6 haptics.

47. The intraocular lens device of any one of claims 1-46, wherein the plurality of haptics are flexible, collapsible, and / or deformable; optionally wherein the plurality of haptics are deformable for insertion into a capsular bag of an eye.

48. The intraocular lens device of any one of claims 1-47, wherein the plurality of haptics are self-expandable; optionally wherein the plurality of haptics are self-expandable upon insertion into a capsular bag of an eye.

49. The intraocular lens device of any one of claims 1-48, wherein at least one haptic or each of the plurality of haptics has a wire shape, a boomerang wire shape, an arcing wire shape, a thin, cylindrical wire shape, or a petal-like shape.

50. The intraocular lens device of any one of claims 1-49, wherein at least one haptic or each of the plurality of haptics has a pathlength in the range of between about 10-16 mm.

51. The intraocular lens device of any one of claims 1-50, wherein a wingspan between two diametrically opposed haptics of the plurality of haptics comprises the distance between the points of peak convexity of each haptic; optionally wherein a configuration comprising two haptics has a wingspan that is in the range of between about 5.0-16 mm.

52. The intraocular lens device of any one of claims 1-51, wherein a single haptic has a curve at the point of peak convexity comprising a radius in the range of between about 3-15 mm.

53. The intraocular lens device of any one of claims 1-52, wherein the plurality of haptics are suitable for pressing against the tissue of the sulcus of the eye upon implantation.

54. The intraocular lens device of any one of claims 1-53, wherein the plurality of haptics are suitable for supporting the device within a capsular bag upon implantation in an eye.

55. The intraocular lens device of any one of claims 1-54, wherein the plurality of haptics are configured to support the weight of the device.

56. The intraocular lens device of any one of claims 1-55, wherein the plurality of haptics are configured to be non-abrasive and / or non-irritating to the sulcus of an eye and / or to the cornea of an eye.

57. The intraocular lens device of any one of claims 1-56, wherein the device is configured to be inserted in a capsular bag of an eye; optionally the device comprises an anti-lens epithelial cell proliferation coating and / or is made of a material which allows removal of proliferating cells.

58. The intraocular lens device of any one of claims 1-57, wherein the device is flexible; optionally wherein the device is flexible enough to be loaded into a cartridge for implantation.

59. The intraocular lens device of any one of claims 1-58, wherein the device is collapsible, compressible and / or foldable; optionally wherein the device is collapsible, compressible and / or foldable enough to be loaded into a cartridge for implantation; optionally wherein the device is collapsible, compressible and / or foldable enough to be insertable using a pair of forceps or other grasping instrument, and / or injectable by a needle and / or a cartridge; optionally injectable by a cartridge with a width of about 2.4 mm.

60. The intraocular lens device of any one of claims 1-59, wherein the device is configured to be inserted in a capsular bag of an eye after removal of a lens.

61. The intraocular lens device of any one of claims 1-60, wherein the device is sized and shaped for implantation into a capsular bag of an eye.

62. The intraocular lens device of any one of claims 1-61, wherein the device is configured to be inserted in an eye lacking a capsular bag.

63. The intraocular lens device of any one of claims 1-62, wherein the device is sized andscaled to accommodate a size of an eye.

64. An intraocular lens system, comprising an intraocular lens (IOL) within the cavity of the intraocular lens device of any one of claims 1-63.

65. The intraocular lens system of claim 64, wherein the intraocular lens device comprises 1, 2, or 3 IOLS.

66. A method of implanting an intraocular lens (IOL) into the eye of a subject, comprising: i) injecting the intraocular lens device of any one of claims 1-63 into an eye of a subject; optionally into a capsular bag of an eye of a subject; and ii) injecting an intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

67. A method of implanting an intraocular lens (IOL) into the eye of a subject, comprising injecting the intraocular lens system of claim 64 or claim 65 into an eye of a subject.

68. A method of implanting an intraocular lens (IOL) into the eye of a subject, comprising: i) injecting the intraocular lens device of any one of claims 1-63 into an eye of a subject, wherein the eye of the subject lacks a capsular bag or has a damaged capsular bag; ii) securing the intraocular lens device within the eye of the subject by employing a de-roofed needle and thread to externalize and affix a portion of two haptics of the plurality of haptics through the sclera of the eye of the subject; and iii) injecting an intraocular lens (IOL) into the injected intraocular lens device residing in the capsular bag of the subject’s eye.

69. A method of implanting an intraocular lens (IOL) into the eye of a subject, comprising:i) injecting the intraocular lens system of claim 64 or claim 65 into an eye of a subject, wherein the eye of the subject lacks a capsular bag or has a damaged capsular bag; and ii) securing the intraocular lens device within the eye of the subject by employing a de-roofed needle and thread to externalize and affix a portion of two haptics of the plurality of haptics through the sclera of the eye of the subject.

70. A method of forming an opening sufficient for insertion of an IOL haptic, comprising piercing or opening a portion of the continuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring of the intraocular lens device of any one of claims 20-63.

71. A method of preparing the intraocular lens system of claim 64 or claim 65, comprising piercing or opening a portion of the continuous recess, the plurality of perforations, or the plurality of slits, or combinations thereof, along the circumference of the intraocular ring of said intraocular lens device sufficient to insert an IOL haptic.

Images