Liquid sample test device

Abstract

The present disclosure relates to the technical field of biological test devices. Provided is a liquid sample test device, comprising a base layer. Using an opening structure can ensure sufficient contact of a liquid sample with a test element and the flow of the liquid sample. A blocking portion can block a liquid that rushes into a test slot via the opening structure, and the blocking portion can block an instantaneous liquid impact passing through the opening structure, such that the base layer can instantaneously resist the introduction of a large amount of liquid into the test slot during the introduction of the liquid sample, thereby avoiding a "flooding" phenomenon in the test slot, and alleviating the technical problems in the prior art whereby, during sample testing, the liquid sample tends to flow improperly in the test element or directly flows into a non-test area of the test element, affecting the accuracy of a test result, and possibly resulting in sample leakage and environmental contamination.

Description

Liquid sample testing device

[0001] Cross Reference to Related Applications

[0002] This application claims priority to the Chinese patent application No. 2024207358026, filed on April 10, 2024, and entitled “Liquid sample testing device”, the content of which is incorporated herein by reference in its entirety. TECHNICAL FIELD

[0003] The present disclosure relates to the technical field of biological detection devices, in particular to a liquid sample testing device. BACKGROUND

[0004] For many sample testing devices, it is necessary to take samples from the sample collector before testing, which is inefficient. During the testing process, adverse phenomena such as no strip running or flooding often occur, affecting the accuracy of the test results, and may cause sample leakage and environmental pollution.

[0005] SUMMARY

[0006] The purpose of the present disclosure is to provide a liquid sample testing device to alleviate the technical problems that in the existing sample testing process, it is easy to cause no strip running or liquid sample directly flowing into the non-testing area of the testing element, forming a “flooding” phenomenon, affecting the accuracy of the test results, and may cause sample leakage and environmental pollution.

[0007] The present disclosure provides a liquid sample testing device, comprising: a base layer;

[0008] The base layer has a test slot accommodating a testing element, and one end of the base layer corresponding to the test slot is in a closed structure, and the other end is in an open structure.

[0009] The test slot comprises a bottom wall, and the bottom wall is provided with a blocking portion at one end close to the open structure, the blocking portion can abut against the testing element, and the blocking portion is configured to block the liquid flowing into the test slot through the open structure.

[0010] In a preferred embodiment of the present disclosure, the blocking portion comprises a blocking protrusion.

[0011] The test slot further comprises a side wall, the blocking protrusion is arranged along the surface of the bottom wall, the blocking protrusion abuts against the side wall, and the blocking protrusion is configured to block the instantaneous liquid impact.

[0012] In a preferred embodiment of the present disclosure, the blocking portion further comprises a trapping groove.

[0013] The trapping groove is located on a side of the blocking protrusion away from the opening structure, the trapping groove is in abutment with the side wall, and the trapping groove is configured to trap liquid that has passed over the blocking protrusion.

[0014] In a preferred embodiment of the present disclosure, the blocking protrusion is arranged in an inclined manner along an end close to the opening structure to another end, and the height of the blocking protrusion close to the opening structure to the bottom wall is greater than the height of the other end.

[0015] In a preferred embodiment of the present disclosure, an end of the blocking protrusion away from the opening structure extends into the trapping groove.

[0016] In a preferred embodiment of the present disclosure, a side surface of the blocking protrusion close to the opening structure extends in an arc shape;

[0017] A side surface of the trapping groove close to the blocking protrusion extends in an arc shape.

[0018] In a preferred embodiment of the present disclosure, a sealing protrusion is arranged on the side wall.

[0019] The sealing protrusion can be in abutment with the side wall of the test element located in the test groove to seal to limit the flow of liquid entering the test groove through the gap between the side wall and the test element.

[0020] In a preferred embodiment of the present disclosure, a plurality of sealing protrusions are arranged, and the plurality of sealing protrusions are arranged at intervals along the extension direction of the side wall, wherein at least one of the sealing protrusions is located at the position of the trapping groove.

[0021] In a preferred embodiment of the present disclosure, a plurality of test grooves are arranged, and the plurality of test grooves are arranged at intervals along the base layer, and any two adjacent test grooves are independently separated by the side wall.

[0022] In a preferred embodiment of the present disclosure, a cover layer and a protective sleeve are further included.

[0023] The cover layer is connected to a side of the base layer away from the bottom wall, and the cover layer is configured to form a sealed test cavity for the test groove.

[0024] The protective sleeve is sleeved outside the base layer and the cover layer through one end of the opening structure, and the protective sleeve is in abutment with the base layer and the cover layer, respectively.

[0025] The present disclosure provides a liquid sample detection device, including a base layer, a cover layer, and a microfluidic structure.

[0026] The base layer has a test groove for accommodating a test element, and one end of the base layer corresponds to the test groove and has a closed structure, and the other end has an open structure;

[0027] The microfluidic structure is connected to the end of the base layer having the open structure, the cover layer covers the microfluidic structure, the side of the base layer away from the cover layer has a liquid inlet, the microfluidic structure is provided with an exhaust hole corresponding to the test groove, and the exhaust hole is arranged in a serpentine shape.

[0028] In a preferred embodiment of the present disclosure, the test groove includes a bottom wall, the bottom wall is provided with a blocking portion near one end of the open structure, the blocking portion can abut against the test element, and the blocking portion is configured to block the liquid flowing into the test groove through the open structure.

[0029] In a preferred embodiment of the present disclosure, a spacing portion is further included.

[0030] The spacing portion corresponds to the side wall of the test groove, and any two adjacent spacing portions form a containing groove configured to hold the test element.

[0031] Each containing groove is provided with one exhaust hole.

[0032] In a preferred embodiment of the present disclosure, a buffer portion is further included.

[0033] The buffer portion includes an abutting section and an inclined section which are integrally formed, the abutting section is connected to the microfluidic structure, the inclined section is arranged in an inclined manner from one end of the abutting section to the liquid inlet, and the distance between the inclined section and the test element gradually increases from one end of the abutting section to the other end.

[0034] The liquid sample detection device provided by the present disclosure includes a base layer, the base layer has a test groove for accommodating a test element, and one end of the base layer corresponds to the test groove and has a closed structure, and the other end has an open structure; the open structure can ensure sufficient contact and flow of the liquid sample and the test element; the test groove includes a bottom wall, the bottom wall is provided with a blocking portion near one end of the open structure, the blocking portion can abut against the test element, the blocking portion can block the liquid flowing into the test groove through the open structure, the blocking portion can block the instantaneous liquid impact through the open structure, so that the base layer can resist a large amount of liquid entering the test groove at the moment of entering the liquid sample, avoid the "flooding" phenomenon in the test groove, and alleviate the technical problems existing in the prior art, such as the non-running strip phenomenon or the liquid sample directly flowing into the non-test area of the test element during the sample test process, affecting the accuracy of the detection result, and possibly causing sample leakage and environmental pollution. BRIEF DESCRIPTION OF DRAWINGS

[0035] In order to more clearly illustrate the technical solutions in the specific embodiments of the present disclosure or the prior art, the following will briefly introduce the drawings needed to be used in the description of the specific embodiments or the prior art. Obviously, the drawings described below are only some embodiments of the present disclosure, and all other drawings obtained by those of ordinary skill in the art without creative work based on these drawings are within the protection scope of the present disclosure.

[0036] Fig. 1 is a schematic diagram of the overall appearance structure of the liquid sample detection device provided by the embodiments of the present disclosure;

[0037] Fig. 2 is a schematic diagram of the structure of the base layer and the test element of the liquid sample detection device provided by the embodiments of the present disclosure after assembly;

[0038] Fig. 3 is a schematic diagram of the structure of the base layer of the liquid sample detection device provided by the embodiments of the present disclosure;

[0039] Fig. 4 is a schematic diagram of the local enlarged structure of the base layer of the liquid sample detection device provided by the embodiments of the present disclosure;

[0040] Fig. 5 is a schematic diagram of the structure of the liquid sample detection device with a microfluidic structure provided by the embodiments of the present disclosure;

[0041] Fig. 6 is a schematic diagram of the structure of the liquid sample detection device with the microfluidic structure and the base layer forming an integral whole provided by the embodiments of the present disclosure;

[0042] Fig. 7 is a schematic diagram of the cross-sectional structure of the liquid sample detection device with a microfluidic structure provided by the embodiments of the present disclosure;

[0043] Fig. 8 is a schematic diagram of the local enlarged structure of the liquid sample detection device with a microfluidic structure provided by the embodiments of the present disclosure.

[0044] Fig. 1 is a schematic diagram of the overall appearance structure of the liquid sample detection device provided by the embodiments of the present disclosure; DETAILED DESCRIPTION

[0045] The technical solutions of the present disclosure will be described below in conjunction with the embodiments. Obviously, the described embodiments are only some of the embodiments of the present disclosure, but not all the embodiments. Based on the embodiments in the present disclosure, all other embodiments obtained by those of ordinary skill in the art without creative work are within the protection scope of the present disclosure.

[0046] As shown in FIGS. 1-8, the liquid sample detection device provided by the embodiment includes a base layer 100, the base layer 100 has a test groove 300 accommodating a test element 200, one end of the base layer 100 corresponding to the test groove 300 is in a closed structure 110, and the other end is in an open structure 120; the test groove 300 includes a bottom wall 310, and the bottom wall 310 is provided with a blocking part 400 close to one end of the open structure 120, the blocking part 400 can abut against the test element 200, and the blocking part 400 is configured to block the liquid poured into the test groove 300 through the open structure 120.

[0047] It should be noted that the liquid sample detection device provided by the embodiment can adjust the flow of the liquid in the corresponding stage during the liquid sample detection process, so as to ensure that the liquid sample can meet the sufficient contact reaction with the test element 200, avoid the liquid sample from impacting the test groove 300, ensure the accuracy of the test result, and avoid the possibility of liquid sample leakage and environmental pollution; specifically, the base layer 100 is used as a basic placement structure of the test element 200, one end of the base layer 100 is in the closed structure 110, and the other end is in the open structure 120, which can ensure the contact of the liquid sample on the basis of protecting the test element 200; wherein the test groove 300 can be selected based on the structure of the test element 200, generally, the test groove 300 and the test element 200 are in a rectangular structure, the test groove 300 can accommodate one test element 200, and one end of the test element 200 can extend out of the test groove 300 to contact the liquid sample through the open structure 120; optionally, the blocking part 400 is used as a structure for blocking the flow of the liquid in the test groove 300, the blocking part 400 is arranged on the bottom wall 310 of the test groove 300, and the blocking part 400 abuts against the surface of the test element 200, when the base layer 100 drives the test element 200 to contact the liquid sample through the open structure 120, the liquid sample will instantaneously impact the test element 200 and the test groove 300, in order to avoid the liquid sample from instantaneously impacting the test groove 300, the blocking part 400 can block and buffer the liquid sample, so that the liquid sample gradually reacts along one end of the test element 200 close to the open structure 120 for testing, which relieves the "flooding" phenomenon in the test groove 300, avoids a large amount of liquid sample from invading the test element 200 in various directions, and solves the technical problem of inaccurate test result.

[0048] Optionally, the test element 200 comprises a test strip, which can take a variety of forms, for example, in the form of an immunoassay or a chemical test, configured to detect an analyte in a sample, for example, a drug of abuse or a related metabolite indicative of a physical condition; when the test element 200 is a test strip, it can be made of a variety of materials, either absorbent or non-absorbent, and a test strip can use a variety of materials configured to facilitate the transfer of a liquid; one material of a test strip can be layered on another test strip material, for example, filter paper layered on nitrocellulose; alternatively, at least one region of a test strip can be positioned after another region of at least one different material; a test strip can be configured to provide feedback by applying a solution of a signal-generating substance to the surface of an application region or by soaking one or more materials in a signal solution. The various regions of a test strip can be arranged as follows: a complete necessary test strip can include a sample application region and a test region. Typically, a liquid first contacts the sample application region and then flows to the test region based on capillary action, and these regions are made of different materials and are connected together in the direction of liquid transfer.

[0049] Optionally, the liquid sample can be derived from a solid or semi-solid sample, including excretions, biological tissue and food samples, and the solid or semi-solid sample can be converted into a liquid sample using any suitable method, for example, mixing, mashing, macerating, incubating, dissolving or digesting the solid sample using enzymatic action in a suitable solution. The liquid sample can be derived from an animal, a plant and a food sample, for example, including urine, saliva, blood and its components, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissue, organs, tumors, cultures of tissue and organs, cell cultures and media, optionally, the biological sample is urine. Among them, drug of abuse (DOA) refers to the use of drugs for non-medical purposes. The abuse of these drugs can cause physical and mental damage, dependence, addiction and / or death. These drugs are absorbed by the human body and decomposed into different small molecule substances, which exist in blood, urine, saliva, sweat and other body fluids or part of the body fluids exist in the above small molecule substances; the test element 200 can test the drug of abuse based on the test reaction to provide feedback.

[0050] The liquid sample detection device provided by the embodiment comprises a base layer 100; the base layer 100 has a test groove 300 accommodating a test element 200, one end of the base layer 100 corresponding to the test groove 300 is in a closed structure 110, and the other end is in an open structure 120; the open structure 120 can ensure sufficient contact and flow of the liquid sample and the test element 200; the test groove 300 comprises a bottom wall 310, and a blocking part 400 is arranged at one end of the bottom wall 310 close to the open structure 120; the blocking part 400 can abut against the test element 200, and can block the liquid flowing into the test groove 300 through the open structure 120; the blocking part 400 can block the instantaneous liquid impact through the open structure 120, so that the base layer 100 can resist a large amount of liquid from entering the test groove 300 at the moment of entering the liquid sample, thereby avoiding the “flooding” phenomenon in the test groove 300, and relieving the technical problems that the sample test process is prone to not running stripes or the liquid sample directly flows into the non-test area of the test element 200 in the prior art, which affects the accuracy of the detection result, and may cause sample leakage and environmental pollution.

[0051] Optionally, in the preferred embodiment of the present disclosure, the blocking part 400 comprises a blocking protrusion 410 and a trapping groove 420; the test groove 300 further comprises a side wall 320, the blocking protrusion 410 is arranged along the surface of the bottom wall 310, the blocking protrusion 410 abuts against the side wall 320, and the blocking protrusion 410 is configured to block the instantaneous liquid impact; the trapping groove 420 is located on the side of the blocking protrusion 410 away from the open structure 120, the trapping groove 420 abuts against the side wall 320, and the trapping groove 420 is configured to trap the liquid passing over the blocking protrusion 410.

[0052] In the embodiment, the blocking protrusion 410 can be raised along the surface of the bottom wall 310; when the test element 200 is placed in the test groove 300, the blocking protrusion 410 can abut against the test element 200, that is, the blocking protrusion 410 is a structure at one end of the bottom wall 310 close to the open structure 120; at the moment when the test groove 300 contacts the liquid sample through the open structure 120, the liquid sample will flow in the direction of the closed structure 110 along the bottom wall 310 of the test groove 300; the blocking protrusion 410 can block the liquid sample, so that the liquid sample cannot enter the end of the test groove 300 close to the closed structure 110 through the blocking protrusion 410; when the liquid sample contacts the base layer 100 and tends to be stable, the liquid sample will gradually perform a wetting reaction along the test element 200, thereby avoiding the possibility that the impact of the liquid sample causes inaccurate feedback of the test element 200, and reducing the possibility of the “flooding” phenomenon of the test groove 300.

[0053] Optionally, the trapping groove 420 is located on the side of the blocking protrusion 410 away from the opening structure 120, and the trapping groove 420 can be recessed along the surface of the bottom wall 310, that is, when part of the liquid sample impacts the blocking protrusion 410 and passes the blocking protrusion 410 along the gap between the blocking protrusion 410 and the test element 200, the trapping groove 420 can trap and store the part of the liquid sample in the trapping groove 420, thereby better ensuring that the liquid sample does not enter the test slot 300 and affect the normal use of the test element 200.

[0054] In a preferred embodiment of the present disclosure, the blocking protrusion 410 is inclined from one end close to the opening structure 120 to the other end.

[0055] In a preferred embodiment of the present disclosure, the end of the blocking protrusion 410 away from the opening structure 120 extends into the trapping groove 420.

[0056] In the present embodiment, the blocking protrusion 410 is arranged adjacent to the trapping groove 420, that is, the end of the blocking protrusion 410 close to the opening structure 120 is the highest point, and the blocking protrusion 410 extends downward and downward from the highest point until the blocking protrusion 410 extends to the lowest point of the trapping groove 420. With the inclined blocking protrusion 410, the liquid sample that passes the blocking protrusion 410 can slowly enter the trapping groove 420 along the inclined surface, slowing down the impact of the liquid sample. At the same time, the liquid sample entering the trapping groove 420 is also blocked by the side wall of the trapping groove 420 away from the blocking protrusion 410, thereby better trapping and storing the liquid sample in the trapping groove 420, ensuring the stability of the liquid sample flow.

[0057] In a preferred embodiment of the present disclosure, the side surface of the blocking protrusion 410 toward the opening structure 120 extends in an arc shape; and the side surface of the trapping groove 420 toward the blocking protrusion 410 extends in an arc shape.

[0058] In the present embodiment, the end of the blocking protrusion 410 toward the opening structure 120 can extend in a crescent shape. With the concave surface of the crescent shape directly facing the impact of the liquid sample, the liquid sample can be better buffered and slowed down. Similarly, when part of the liquid sample passes the blocking protrusion 410 and enters the trapping groove 420, the side wall 320 of the trapping groove 420 also extends in a crescent shape, and the concave surface of the crescent shape can also be used to directly face the impact of the liquid sample. Optionally, the liquid sample can be buffered and slowed down to maximize the blocking and trapping of the liquid sample at the blocking portion 400.

[0059] In the preferred embodiment of the present disclosure, the side wall 320 is provided with a sealing protrusion 500; the sealing protrusion 500 can be in abutting sealing with the side wall 320 of the test element 200 located in the test groove 300, so as to limit the liquid flowing into the test groove 300 through the gap between the side wall 320 and the test element 200.

[0060] In the present embodiment, when the test element 200 is placed in the test groove 300, it cannot be guaranteed that the test element 200 and the side wall 320 are completely attached, which may cause a capillary gap between the test element 200 and the side wall 320, and the capillary gap may cause the liquid sample to enter the test groove 300 and wet the test element 200 in advance, thereby causing inaccurate detection results. By providing the sealing protrusion 500 on the side wall 320, the sealing protrusion 500 can adopt a pointed protrusion structure similar to a card fir structure, and the sealing protrusion 500 can reduce, prevent or limit capillary flow. Since the sealing protrusion 500 protrudes from the side wall 320, when the test element 200 has a width comparable to or close to that of the test groove 300, the sealing protrusion 500 can press the test element 200 when the test element 200 is placed in the test groove 300, so that the side of the test element 200 is in contact with the side wall 320 of the test groove 300, thereby preventing capillary flow. In addition, even if there is a capillary gap between the test element 200 and the side wall 320 of the test groove 300, the sealing protrusion 500 is in close contact with the test element 200, and the liquid sample opened on the opening structure 120 is blocked at the sealing protrusion 500, so that the liquid sample cannot continue to flow downstream along the capillary gap, thereby avoiding the possibility that the liquid sample in the capillary gap contacts the test element 200 in advance.

[0061] In the preferred embodiment of the present disclosure, the sealing protrusion 500 is provided in a plurality, and the plurality of sealing protrusions 500 are arranged at intervals along the extension direction of the side wall 320.

[0062] In the present embodiment, by arranging a plurality of sealing protrusions 500 along the side wall 320, the plurality of sealing protrusions 500 can better avoid capillary flow of the liquid sample in the test groove 300, improve the directional flow of the liquid sample, and better ensure the accuracy of the test results. Optionally, at least one sealing protrusion 500 is located at the position of the trapping groove 420.

[0063] In the preferred embodiment of the present disclosure, the test groove 300 is provided in a plurality of groups, and the plurality of groups of test grooves 300 are arranged at intervals along the base layer 100, and any two adjacent test grooves 300 are independently separated by the side wall 320.

[0064] In the embodiment, the plurality of test grooves 300 are mutually isolated structures, one test groove 300 contains one test element 200, and through the plurality of test grooves 300, the requirement of simultaneously detecting a plurality of liquid samples can be achieved, and meanwhile, any two adjacent test grooves 300 are independently separated by the side wall 320, so as to avoid mutual interference between the test elements 200 and result in misjudgment.

[0065] In the preferred embodiment of the present disclosure, a cover layer 600 and a protective sleeve 700 are further included; the cover layer 600 is connected to the side of the base layer 100 away from the bottom wall 310, and the cover layer 600 is configured to form a sealed test cavity for the test groove 300; the protective sleeve 700 is sleeved outside the base layer 100 and the cover layer 600 through one end of the opening structure 120, and the protective sleeve 700 abuts against the base layer 100 and the cover layer 600, respectively.

[0066] Optionally, the base layer 100 can be made of transparent material, or the cover layer 600 can be made of transparent material, and optionally, the base layer 100 is made of transparent material, which facilitates observation of the test reaction of the test element 200 inside the test groove 300.

[0067] In the embodiment, the side of the base layer 100 away from the bottom wall 310 of the test groove 300 is in an open structure, the cover layer 600 can be placed at the open structure of the base layer 100, and the cover layer 600 can be used to fix the test element 200 in the test groove 300, so as to ensure that the test element 200 is fixed in the test groove 300, and also to ensure that the end of the test element 200 is exposed at the opening structure 120; the protective sleeve 700 can protect the test element 200 through one end of the opening structure 120, and also can avoid possible separation of the base layer 100 and the cover layer 600, in addition, the protective sleeve 700 can form end sealing for the test element 200 and the test groove 300 after the test is completed, so as to avoid the possibility of liquid sample leakage and environmental pollution after the test is completed.

[0068] As shown in FIGS. 5-8, the present embodiment provides a liquid sample detection device, which comprises a base layer 100, a cover layer 600 and a microfluidic structure 800; the base layer 100 has a test groove 300 containing a test element 200, one end of the base layer 100 corresponding to the test groove 300 is in a closed structure 110, and the other end is in an opening structure 120;

[0069] The microfluidic structure 800 is connected to one end of the base layer 100 having the opening structure 120, the cover layer 600 covers the microfluidic structure 800, the side of the base layer 100 away from the cover layer 600 has a liquid inlet 900, the microfluidic structure 800 is provided with an exhaust hole 810 corresponding to the test groove 300, and the exhaust hole 810 is arranged in a serpentine shape.

[0070] The liquid sample detection device provided by the embodiment can be used as a separate product, or can be combined with the blocking part 400 to form a combined product. When the base layer is fixedly connected with the microfluidic structure 800, the microfluidic structure 800 can form a seal with the opening structure 120, and because the microfluidic structure 800 and the base layer 100 have the liquid inlet 900 through which the liquid sample flows, when the liquid sample flows through the liquid inlet 900 and contacts the test element 200 and the test groove 300, the excess gas in the test groove 300 can be directly discharged through the exhaust hole 810, so that sufficient liquid sample can enter the test groove 300, and the test element 200 can be fully contacted with the liquid sample. The exhaust hole 810 arranged in a serpentine manner can better prevent the liquid sample that has entered the test groove 300 from flowing out of the exhaust hole 810.

[0071] When the base layer has the microfluidic structure 800 and the blocking part 400, the blocking part 400 is a structure that blocks the flow of liquid in the test groove 300, and the microfluidic structure 800 can directly discharge the excess gas in the test groove 300 through the exhaust hole 810. When the base layer 100 drives the test element 200 to contact the liquid sample through the liquid inlet 900, the liquid sample will instantaneously impact the test element 200 and the test groove 300. In order to avoid the instantaneous impact of the liquid sample on the test groove 300, the blocking part 400 can form a blocking buffer for the liquid sample, so that the liquid sample gradually performs reaction testing along the end of the test element 200 close to the liquid inlet 900, and the "flooding" phenomenon in the test groove 300 is alleviated, and a large amount of liquid sample does not invade the test element 200 in all directions, thereby avoiding the technical problem of inaccurate test results.

[0072] On the basis of the above embodiment, optionally, in the preferred embodiment of the present disclosure, a spacing part 1100 is further included; the spacing part 1100 corresponds to the side wall of the test groove 300, and any two adjacent spacing parts 1100 form a containing groove configured to clamp the test element 200; each containing groove is provided with an exhaust hole 810.

[0073] In the preferred embodiment of the present disclosure, a buffer part 1200 is further included; the buffer part 1200 includes an abutment section 1210 and an inclined section 1220 which are integrally formed, the abutment section 1210 is connected with the microfluidic structure 800, the inclined section 1220 is arranged in an inclined manner from one end of the abutment section 1210 to the liquid inlet 900, and the distance between the inclined section 1220 and the test element 200 gradually increases from one end close to the abutment section 1210 to the other end.

[0074] In the embodiment, the spacing part 1100 can be arranged corresponding to the test groove 300, the accommodation groove formed by the spacing part 1100 can test the end part of the test element 200 to form a clamping spacing arrangement, the position of the accommodation groove abutting the microfluidic structure 800 has a buffer part 1200, the buffer part 1200 is arranged corresponding to the bottom wall 310 of the test groove 300, and the height of the abutting section 1210 is matched with the height of the bottom wall 310, and the inclined section 1220 can gradually contact the liquid sample of the test element 200 along the position of the liquid inlet 900, so as to ensure that the test element 200 is in sufficient contact with the liquid sample; and the excess gas in the test groove 300 can be directly discharged through the exhaust hole 810.

[0075] It should be noted that the liquid sample detection device provided in the embodiment and the liquid sample detection device provided in the above embodiment can be independent products or can be combined to form a combined product. Since the other technical effects of the liquid sample detection device provided in the embodiment are the same as those of the liquid sample detection device provided in the above embodiment, the details are not repeated here.

[0076] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present disclosure, and not to limit them; although the present disclosure has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacements for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present disclosure. Industrial applicability

[0077] The liquid sample detection device provided by the present disclosure comprises a base layer; the base layer has a test groove for accommodating a test element, one end of the base layer is in a closed structure, and the other end is in an open structure; the open structure can ensure sufficient contact and flow of the liquid sample and the test element; the test groove comprises a bottom wall, one end of the bottom wall near the open structure is provided with a blocking part, the blocking part can abut against the test element, and the blocking part can block the liquid flowing into the test groove through the open structure; the blocking part can block the instantaneous liquid impact through the open structure, so that the base layer can resist a large amount of liquid entering the test groove at the moment of entering the liquid sample, avoid the "flooding" phenomenon in the test groove, and alleviate the technical problems of the prior art, such as the non-running strip phenomenon or the liquid sample directly flowing into the non-test area of the test element during the sample test process, affecting the accuracy of the detection result, and possibly causing sample leakage and environmental pollution.

Claims

1. A liquid sample detection device, characterized in that: include: Grassroots (100); The base layer (100) is provided with a test slot (300) for accommodating a test element (200); one end of the base layer (100) corresponding to the test slot (300) is in a closed structure (110), and the other end is in an open structure (120); The test slot (300) includes a bottom wall (310), and a blocking portion (400) is provided at one end of the bottom wall (310) close to the opening structure (120). The blocking portion (400) can abut against the test element (200), and the blocking portion (400) is configured to form a barrier against liquid that flows into the test slot (300) through the opening structure (120).

2. The liquid sample detection device according to claim 1, characterized in that: The blocking portion (400) includes a blocking protrusion (410); The test slot (300) further includes a side wall (320), the blocking protrusion (410) extending along the surface of the bottom wall (310), the blocking protrusion (410) abutting against the side wall (320), and the blocking protrusion (410) is configured to block instantaneous liquid impact.

3. The liquid sample detection device according to claim 2, characterized in that: The blocking portion (400) further includes a retaining groove (420); The retaining groove (420) is located on a side of the blocking protrusion (410) away from the opening structure (120), the retaining groove (420) abuts against the side wall (320), and the retaining groove (420) is configured to retain liquid that passes over the blocking protrusion (410).

4. The liquid sample detection device according to claim 3, characterized in that: The blocking protrusion (410) is arranged obliquely from one end close to the opening structure (120) to the other end, and the height of the blocking protrusion (410) from one end close to the opening structure (120) to the bottom wall (310) is greater than the height of the other end.

5. The liquid sample detection device according to claim 4, characterized in that: One end of the blocking protrusion (410) away from the opening structure (120) extends into the interior of the retaining groove (420).

6. The liquid sample detection device according to claim 5, characterized in that: The blocking protrusion (410) extends in an arc shape on one side surface toward the opening structure (120); The retaining groove (420) extends in an arc shape on one side surface toward the blocking protrusion (410).

7. The liquid sample detection device according to claim 1, characterized in that: The test slot (300) further includes a side wall (320), and a sealing protrusion (500) is provided on the side wall (320); The sealing protrusion (500) can abut and seal against the side wall (320) of the test element (200) located in the test slot (300) to limit the liquid entering the test slot (300) from flowing through the gap between the side wall (320) and the test element (200).

8. The liquid sample detection device according to claim 7, characterized in that: A plurality of the sealing protrusions (500) are provided, and the plurality of sealing protrusions (500) are arranged at intervals along the extension direction of the side wall (320).

9. The liquid sample detection device according to claim 8, characterized in that: The test slots (300) are provided in multiple groups, and the multiple groups of test slots (300) are arranged at intervals along the base layer (100), and any two adjacent test slots (300) form an independent separation structure through the side wall (320).

10. The liquid sample detection device according to any one of claims 1 to 9, characterized in that: Also includes a covering layer (600) and a protective cover (700); The covering layer (600) is connected to a side of the base layer (100) facing away from the bottom wall (310), and the covering layer (600) is configured to form the test slot (300) into a sealed test cavity; The protective cover (700) is sleeved on the outside of the base layer (100) and the covering layer (600) through one end of the opening structure (120), and the protective cover (700) is respectively in contact with the base layer (100) and the covering layer (600).

11. A liquid sample detection device, characterized in that: It includes a base layer (100), a cover layer (600) and a microfluidic structure (800); The base layer (100) is provided with a test slot (300) for accommodating a test element (200); one end of the base layer (100) corresponding to the test slot (300) is in a closed structure (110), and the other end is in an open structure (120); The microfluidic structure (800) is connected to one end of the base layer (100) having the opening structure (120), the covering layer (600) covers the microfluidic structure (800), and the base layer (100) has a liquid inlet (900) on a side facing away from the covering layer (600). The microfluidic structure (800) is provided with an exhaust hole (810) corresponding to the test slot (300), and the exhaust hole (810) is arranged in a serpentine shape.

12. The liquid sample detection device according to claim 11, characterized in that: The test slot (300) includes a bottom wall (310), and a blocking portion (400) is provided at one end of the bottom wall (310) close to the opening structure (120). The blocking portion (400) can abut against the test element (200), and the blocking portion (400) is configured to form a barrier against liquid that flows into the test slot (300) through the opening structure (120).

13. The liquid sample detection device according to claim 11 or 12, characterized in that: Also included is a spacer (1100); The partitions (1100) correspond to the side walls of the test slot (300), and a receiving slot configured to clamp the test element (200) is formed between any two adjacent partitions (1100); Each of the accommodating grooves is correspondingly provided with an exhaust hole (810).

14. The liquid sample detection device according to claim 13, characterized in that: Also includes a buffer portion (1200); The buffer portion (1200) includes an integrally formed abutting section (1210) and an inclined section (1220), wherein the abutting section (1210) is connected to the microfluidic structure (800), and the inclined section (1220) is arranged at an angle from one end of the abutting section (1210) to the liquid inlet (900), and the distance between the inclined section (1220) and the test element (200) gradually increases from one end close to the abutting section (1210) to the other end.

15. The liquid sample detection device according to claim 10, characterized in that: The base layer (100) is made of a transparent material, or the cover layer (600) is made of a transparent material.

16. The liquid sample detection device according to claim 12, characterized in that: The base layer (100) has an open structure on one side facing away from the bottom wall (310) of the test slot (300); the covering layer (600) is placed on the open structure of the base layer (100); and the covering layer (600) is used to fix the test element (200) in the test slot (300).

17. The liquid sample detection device according to claim 14, characterized in that: The buffer portion (1200) is arranged corresponding to the bottom wall (310) of the test slot (300), and the height of the abutting section (1210) is adapted to the height of the bottom wall (310).

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