Method for calculating technified ketogenic therapy to induce a ketogenic state

Abstract

The present invention relates to a method for calculating technified ketogenic therapy to induce a ketogenic state. The method comprises analysing a user's physiological and health data to determine calorie intake, food diet percentage and food formula, and a ketogenic rate derived from food diet. The aforementioned data are used to define the macronutrients required for the user to enter ketosis and the amount of a food formula to be administered to the user depending on their physical and medical conditions, reduce side effects related to a ketogenic diet, and ensure that the user enters a ketogenic state.

Description

[0001] TECHNICALLY DEVELOPED KETOGENIC THERAPY CALCULATION METHOD FOR INDUCING A KETOGENIC STATE TECHNICAL FIELD This disclosure relates to computer-implemented methods and systems for personalized nutrition. In particular, this disclosure relates to personalized nutritional methods and systems for inducing a ketogenic state in an individual. DESCRIPTION OF THE PRIOR ART High-carbohydrate diets can have harmful effects on the human body. For example, consuming high-glycemic sugars such as refined sugars can cause metabolic syndrome, a condition that increases the likelihood of developing cardiovascular disease, diabetes, obesity, high blood pressure, elevated triglyceride levels, and other health conditions. A ketogenic diet is a low-carbohydrate, high-fat, moderate-protein diet that is intended to induce ketosis in a user.For the purposes of this disclosure, ketosis or the ketogenic state is understood to be a metabolic state in which the blood contains a high concentration of ketone bodies, which are the result of the metabolism of fat as the primary energy source. According to some studies, the ketogenic state is considered beneficial for weight loss, diabetes treatment, epilepsy treatment, and other diseases. The ketogenic diet prioritizes foods rich in healthy fats and oils, such as coconut oil, olive oil, nuts, seeds, meats, and fish, and limits carbohydrates, especially those from sugars, fruits, and starches. Achieving ketosis requires taking into account, in addition to the diet, the user's particular physiological characteristics, as well as their health status and conditions that may affect their metabolism.Therefore, there is a need to provide personalized methods to induce ketosis in an individual, optimizing the benefits and minimizing the associated risks.

[0002] Page 1 of 33 Disclosures identified in the prior art are WO2023038137A1 and WO2021006276A which relate to methods for inducing a ketogenic state in an individual. WO2023038137A1 discloses an information processing method wherein biometric information about a user on a ketogenic diet is acquired, the acquired biometric information is sent to a nutritionist's terminal which provides dietary guidance to the user based on the biometric information. The ketogenic menu is defined based on the patient's biometric information via the nutritionist's terminal, and the acquired ketogenic menu is sent to the patient's terminal. The method is intended for cancer patients in whom a ketogenic diet can suppress the proliferation of cancer cells.In particular, WO2023038137A1 discloses that the patient's biological information may include cancer type, cancer progression, body weight, muscle mass, activity level, basal metabolic rate, blood sugar level, blood albumin concentration, and at least one of the mean CRP concentrations. It also discloses that the information processing method outputs restriction data related to the amount of sugar, amount of fat, amount of protein, amount of energy, and proportion of ketones required for a meal of the patient to the nutritionist terminal. With the obtained information, the nutritionist terminal can obtain the information necessary for the nutritionist to specify the ketogenic diet menu.WO2023038137A1 further discloses that if a predetermined condition based on the patient's biological information is met, restriction data is sent to the nutritionist's terminal to produce a second ketogenic diet menu with different ketone ratios for the patient, allowing that if certain dietary conditions are met, an additional tailored menu with different macronutrient and ketone ratios can be generated. WO2023038137A1 also discloses that the dietitian can specify a ketogenic diet menu with a low ketone ratio at a predetermined time, so that the patient's psychological burden can be reduced. The dietitian can further use patient assessment data to adjust the patient's ketogenic diet.

[0003] Page 2 of 33 For its part, WO2021006276A1 relates to a method for predicting the effectiveness of a ketogenic diet in a cancer patient and to a method for selecting an appropriate therapy for a cancer patient who is on a ketogenic diet. In particular, it proposes using specific indices for therapeutic selection, including nutritional status, determined by albumin concentration, and inflammatory status, assessed by blood concentration of C-reactive protein. WO2021006276A1 also discloses that the ketogenic diet can be determined based on the ketone ratio (lipids / (protein + sugar)) (mass ratio). The ketogenic diet includes a diet having a ketone ratio of about 1 or more (preferably about 2 or more, more preferably about 2.5 or more), and the upper limit of the ketone ratio is, for example, about 4 or may be about 3.5.Furthermore, the ketone ratio can be set, for example, at about 1 to about 2, and can be set at about 2 at the time of introduction. The amount of protein and sugar can be any amount as long as the ketone ratio satisfies this definition, but is preferably about 30 g or less per day, more preferably about 20 g or less per day, and even more preferably about 10 g or less per day, or they can be combined depending on the timing. The single intake can be in any range as long as it is within the daily intake range, but is preferably about 10 g or less at a single time.WO2021006276A1 further discloses that the ketogenic diet can also be used in combination with medium chain fatty acid oil, which is also called MCT (medium chain triglyceride) or medium chain fatty acid triglyceride, and is typically composed of 6 to 12 carbon atoms, or 8 to 12 carbon atoms, or 8 to 11 carbon atoms or 8 to 10 carbon atoms. However, there is no evidence in the state of the art of a personalized nutrition method to induce a ketogenic state that takes into account, in addition to the particular conditions of the user, medical criteria and that does not use only foods in order to facilitate ketosis in the user.

[0004] Page 3 of 33 BRIEF DESCRIPTION The present disclosure relates to a personalized nutrition method for inducing a ketogenic state in a user. The method comprises several steps for determining and administering the appropriate nutritional intake, a step a) of determining a daily caloric intake required by the user, a step b) of determining a percentage of intake of a food formula and a percentage of a food diet to be used such that the sum of both percentages is equal to 100% of the total daily intake required and a step c) of selecting a ketogenic rate from the user's food diet.Next, in step d), the macronutrients necessary to induce a ketogenic state are determined according to the ketogenic rate from the food diet selected in step c) and the percentage of food diet intake from step b), and in step e), the user (20) is provided with the food formula (11), where the food formula (11) comprises a caloric intake between 5 and 10 kcal per gram and a ketogenic rate selected from 1:1, 2:1, 3:1 or 4:1. Next, in step f), the necessary caloric intake from the food formula (11) from step e) is calculated according to the percentage of the food formula (11) selected in step b), and in step g), the amount of food formula (11) from step e) necessary to provide the caloric intake of step f) is calculated. Finally, the final ketogenic rate is calculated according to the combination of ketogenic rates of the selected food formula (11) and food diet (12).BRIEF DESCRIPTION OF THE FIGURES FIG. 1 shows a flow diagram of an embodiment of the method for inducing a ketogenic state of the present disclosure. FIG. 2 shows a block diagram of an embodiment of the method for inducing a ketogenic state.

[0005] Page 4 of 33 DETAILED DESCRIPTION This disclosure relates to a personalized nutrition method for inducing a ketogenic state in a user. This state, known for its ability to transform ketone bodies into the body's primary energy source, offers various potential health benefits, including improved weight management,cognitive performance and the control of certain medical conditions. Specifically, the method analyzes the user's physical and health status to determine the user's required daily caloric intake and percentages of food formula and diet to meet the daily caloric requirement. The method determines an appropriate ketogenic rate for the patient from a food formula and a food diet and thus determines the necessary macronutrients of the food diet. Taking into account the characteristics of the food formula, the method determines its caloric intake and the amount of food formula required. Finally, the method recalculates the ketogenic rate according to the selected food formula and diet combination. Referring to FIG. 1, in one embodiment of the disclosure, the personalized nutrition method for inducing a ketogenic state,comprises: a) determining a daily caloric intake (10) required by the user (20); b) determining a percentage intake of a food formula (11) and a percentage of a food diet (12) to be used such that the sum of both percentages is equal to 100% of the total daily intake required; c) selecting a ketogenic rate from the food diet (12) of the user (20); d) determining macronutrients necessary to induce a ketogenic state according to the ketogenic rate from the food diet (12) selected in step c), and the percentage intake of the food diet (12) from step b); e) providing the user (20) with the food formula (11) wherein the food formula (11) comprises a caloric intake between 5 and 10 kcal per gram and a ketogenic rate selected from 1:1, 2:1,3:1 or 4:1; f) calculate the necessary caloric intake from the food formula (11) in step e) according to the percentage of the food formula (11) selected in step b);,

[0006] Page 5 of 33 g) calculate the amount of food formula (11) from step e) necessary to provide the caloric intake of step f); h) calculate the final ketogenic rate according to the combination of ketogenic rates of food formula (11) and food diet (12) selected and the percentage of intake of a food formula (11) and the percentage of a food diet (12) selected in step b). For the understanding of the present disclosure, ketosis or ketogenic state will be understood as the metabolic state in which the body mainly uses ketone bodies as an energy source. To achieve ketosis or a ketogenic state, it is necessary for blood glucose levels to be low so that the body searches for other forms of energy such as fats stored in adipose tissue.Ketone bodies, or ketones, are chemical compounds produced by the liver from fatty acids during periods of prolonged fasting, during intense exercise, or when carbohydrate intake is very low, as in the case of a ketogenic diet. Ketone bodies are an alternative source of energy for the body when blood glucose levels are low. The three main ketone bodies produced by the liver are: Acetoacetate (AcAc), Beta-hydroxybutyrate (BHB), and Acetone. Ketone bodies can be used by many cells in the body, including the brain, as an energy source in place of glucose. During ketosis, ketone body levels in the blood can increase significantly. Ketone bodies have several physiological effects on the body, including reducing appetite, improving mental and cognitive ability, and promoting fat oxidation.On the other hand, excessively high levels of ketone bodies in the blood can cause ketoacidosis. The ketogenic state, or ketosis, is achieved with a ketogenic diet—a low-carb, high-fat diet that induces the body to produce ketones from fats used as an energy source instead of carbohydrates. Normally, the body obtains energy primarily from carbohydrates that are broken down into glucose, but by restricting carbohydrate intake and increasing fat intake, the body begins to burn fat for fuel and produces ketones as a byproduct.

[0007] Page 6 of 33 Additionally, it is widely known as a therapeutic strategy for patients with refractory or drug-resistant epilepsy, that is, patients who do not respond to drug treatments. This dietary approach, by inducing and maintaining the ketogenic state, has shown a remarkable ability to reduce the frequency and severity of seizures in various groups of patients with epilepsy. Refractory epilepsy corresponds to a group of patients with epilepsy who do not respond to treatment with antiepileptic drugs and is approximately 30% of all patients with epilepsy, who, because they are refractory to drugs, require other management options, including the ketogenic diet.Modifications are achieved at various levels of neuroendocrine, metabolic, epigenetic control with the induction of peroxisome proliferative receptors (PPARs) and biochemical, which has led to the proposal of different possibilities through which the ketogenic diet serves to help modulate epileptic seizures. Several mechanisms of action have been described for the use of the ketogenic diet in refractory epilepsy, including modulation of ion channels, modification of neurotransmitter metabolism, modulation of inflammation, increased mitochondrial biogenesis, increased ATP production and, in the case of medium-chain triglycerides, an antiepileptic effect by blocking glutamate receptors, which is the main excitatory neurotransmitter. In accordance with the above, the method to induce a ketogenic state includes: a. Determining a daily dietary caloric intake.Step a) of the method of the present disclosure is to determine the daily caloric intake (10) of the user (20). To determine the daily caloric intake (10) of the user (20), some of the parameters related to the health and physical condition of the user selected from gender, body weight, body composition, level of physical activity, health status, basal metabolism, blood glucose, particular nutritional needs of the user or combinations of the above may be taken into account. In one embodiment of the disclosure, the minimum parameters to determine the caloric intake are gender, age, weight and physical activity.

[0008] Page 7 of 33 For the purposes of this disclosure, body weight shall be understood as the measurement of the user's total mass, including muscle mass, bone mass, body fat, internal organs, and body fluids. Body weight is commonly expressed in kilograms. Body weight is the simplest way to determine a user's caloric intake. Body mass composition, on the other hand, is the distribution of the different components of the human body, such as muscle mass, fat mass, bones, and internal organs. Body composition allows for the evaluation of the user's health and physical condition and, therefore, allows for the determination of the user's caloric intake. Health status refers to the user's general level of physical, mental, and social well-being and is not limited to diseases but includes factors such as functional capacity, quality of life, mental health, and emotional well-being.Basal metabolic rate (BMR) is the amount of energy the body needs to maintain its vital functions at rest, that is, the basic functions necessary to sustain life, such as respiration, blood circulation, body temperature regulation, cellular activity, and other essential metabolic functions. Basal metabolic rate (BMR) represents the majority of a person's daily energy expenditure, contributing approximately 60-70% of the total. This expenditure is influenced by factors such as age, sex, body composition, genetics, and hormonal status. Basal metabolic rate (BMR) helps determine a user's caloric needs. Blood glucose (BG), or blood sugar (glucose) level, is the concentration of glucose in the blood at a given time.On the other hand, nutritional needs refer to specific nutrient requirements that can vary from person to person, depending on factors such as age, sex, weight, height, physical activity level, health status, and other medical conditions or individual circumstances. These needs are unique to each individual and may differ significantly from general nutrient intake recommendations. Other parameters related to a user's specific health conditions, such as specific diseases, disease progression, symptoms, and limitations caused by the particular condition, may also be taken into account.

[0009] Page 8 of 33 A health professional can take these parameters into account to determine the user's necessary caloric requirement (10). On the other hand, government agencies in charge of formulating policies, regulating, supervising and promoting public health in different countries can issue resolutions with recommendations for energy and nutrient intake according to the population type. For illustrative purposes, but not limited to, the daily recommendations for calories and nutrients issued by the Ministry of Health and Social Protection in Colombia, in resolution 003803 of 2016, can be used to determine the daily caloric intake for the population.It should be noted that this recommendation does not take into account the specific health conditions of certain users. Therefore, a specific analysis should be performed for these users, as indicated above. Government guidelines from other countries may also be used. Likewise, for illustrative purposes, but not limited to, Resolution 003803 includes recommended daily energy requirements for the Colombian population of children aged 1 to 18 years with three levels of regular physical activity. These values ​​are presented in Table 1. Table 1: Daily Energy Requirement 1 to 18 years.

[0010] Page 9 of 33 Likewise, for illustrative purposes, but not limited to, Resolution 03803 also includes recommended daily energy requirements for the Colombian male population over 18 years of age with three levels of physical activity. These values ​​are presented in the following table: Table 2: Daily energy requirements for men over 18 years of age. Likewise, for illustrative purposes, but not limited to, Resolution 03803 includes recommendations for daily energy requirements for the Colombian population of women over 18 years of age with three levels of physical activity. These values ​​are presented in the following table:

[0011] Page 10 of 33

[0012] Table 3: Daily energy requirements for women over 18 years of age. Likewise, for illustrative purposes, but not limited to, Resolution 03803 includes recommendations for protein intake. These values ​​are presented in the following table:

[0013] Page 11 of 33

[0014] Table 4: Protein intake recommendations. b. Determine a percentage of intake of a food formula (11) and a percentage of a food diet (12). Once the daily caloric intake (10) required by the user has been determined in step a), the next step is to determine a percentage of intake of a food formula (11) and a percentage of a food diet (12) to be used such that the sum of both percentages is equal to 100% of the total daily intake required. The method of the present disclosure comprises a ketogenic diet in which part of the daily caloric intake comes from a food formula (11) and part of the daily caloric intake comes from a food diet (12). The percentage of food formula (11) is selected according to the particular conditions of the user and can be between 30% and 100%.The user's specific conditions may be targeted by the ketogenic diet, based on individual nutritional needs, nutritional deficiencies, health conditions, dietary habits, and tolerance to the ketogenic diet, among others.

[0015] Page 12 of 33 The goals of the ketogenic diet can be weight loss, increased energy, treatment of a medical condition, among others. The particular goal of each user may change the percentage of food formula to use. The user may also have individual nutritional needs due to health conditions or physical conditions that can also change the percentage of formula to use. A percentage of food formula close to 30% can be considered in users who can consume food without physical limitations and their nutritional status and therefore the food diet (12) provides a greater percentage of the user's caloric requirement. On the other hand, a percentage close to 100% can be used in users with health conditions that prevent them from consuming food and therefore most of their caloric requirement will come from the food formula (11).On the other hand, the percentage of food formula (11) can start at 30% and increase according to the user's response to the diet or their particular health conditions. In addition, the percentage of food formula (11) can start at a high value close to 100% and decrease if the user's health conditions allow them to ingest a food diet (12). c. Selecting a ketogenic rate from the user's food diet (12) (20) Once the percentage of food diet (12) to be used has been determined, a ketogenic rate from said food diet (12) is selected. For the understanding of the present disclosure, the ketogenic rate from the food diet (12) is the ratio of fats to the combined sum of proteins and carbohydrates in the food diet (12). This ratio indicates how many times there is more fat than protein and carbohydrates together.A 2:1 ketogenic ratio means there is twice as much fat as protein and carbohydrates combined, a 3:1 ketogenic ratio means there is three times as much fat as protein and carbohydrates combined, and a 4:1 ketogenic ratio means there is four times as much fat as protein and carbohydrates combined. In one embodiment of the disclosure, the ketogenic ratio of the dietary intake is 2:1. The ketogenic ratio of the dietary intake (12) is calculated in terms of grams per macronutrient. Accordingly, in a 2:1 ketogenic ratio, for every two grams of fat, there is one gram of protein and carbohydrates combined.

[0016] Page 13 of 33 For the purposes of this disclosure, macronutrients are the essential nutrients that the human body needs to stay healthy and function properly. There are three main categories of macronutrients: carbohydrates, proteins, and fats. Carbohydrates are the body's primary source of energy and are found in foods such as cereals and their derivatives, fruits, vegetables, grains, legumes, and dairy products. Carbohydrates are broken down into simple sugars, such as glucose, which the body uses as fuel for daily activities and organ function. Proteins are essential for building and repairing tissues, producing enzymes and hormones, among other functions. Proteins are found in foods such as meat, fish, eggs, dairy products, legumes, nuts, and seeds.Proteins are made up of chains of amino acids, some of which are essential and must be obtained through the diet. Fats, on the other hand, are a concentrated source of energy and are also vital for the absorption of fat-soluble vitamins, hormone production, and brain function. Fats are found in foods such as vegetable oils, nuts, seeds, avocados, fatty fish, and full-fat dairy products. The ketogenic ratio of a diet (12) is selected depending on several factors such as health goals, the user's tolerance to the chosen ketogenic ratio, nutritional needs, and healthcare professional recommendations. A low ketogenic ratio such as 1:1 can be used for weight loss and metabolic syndrome, for example, while higher ratios such as 1:1 can be used for weight loss and metabolic syndrome.5:1, 2:1, 3:1 can be used for example in specific clinical situations as a treatment for refractory or drug-resistant epilepsy and 4:1 ratio can be used for example as a treatment for super refractory status epilepticus. Ketogenic ratios from high diets (12) such as 3:1 or 4:1 can be difficult to maintain due to the high fat intake and low carbohydrate intake. These side effects can be fatigue, dizziness, headaches, irritability, nausea and difficulty concentrating, gastrointestinal discomfort, constipation among others. A high ketogenic ratio from high diets (12) such as 3:1 or 4:1 can be difficult to achieve because it requires eating particular high-fat foods that can be difficult to digest, and it is a restrictive diet because there are few.

[0017] Page 14 of 33 foods that provide the necessary fat to carbohydrate and protein ratio to maintain the ketogenic rate from food formula (12) at 3:1 or 4:1. On the other hand, a 1:1 ketogenic rate is a low rate that may not achieve the desired ketogenic state. To alleviate severe side effects from a high ketogenic rate from food formula (11) or to facilitate entry into the ketogenic state, a higher percentage of food formula (11) from step b) can be used in order to facilitate nutrient intake and ensure the ketogenic state in the user. d.determine macronutrients necessary to induce a ketogenic state according to the ketogenic rate from the food diet (12) selected in step c), and the percentage of intake of the food diet (12) from step b); Once the percentage of the food diet (12) and the ketogenic rate from the food diet (12) have been determined, the macronutrients necessary to induce a ketogenic state from the food diet (12) are determined. To determine these macronutrients, the ketogenic units are first determined. A ketogenic unit is the calorie value at the ketogenic rate from the food diet (12). 1 gram of fat provides 9 calories, 1 gram of protein provides 4 calories. The ketogenic units then depend on the ketogenic ratio of the selected diet (12). In one embodiment of the disclosure, the ketogenic ratio of the selected diet (12) is 2:1. This 2:1 ketogenic ratio of the selected diet (12) has better adherence and is not as food restrictive as a higher ratio. In addition, this 2:1 ratio gets the user into a ketogenic state, which may not occur with lower ratios such as 1:1. The daily ketogenic units are then determined.

[0018] Page 15 of 33^^^^^^^^ ^^^^^^^ ^^^^^é^^^^^ =^^^^^^ ^^^ó^^^^ ^^^^^^ ^^ ^^ ^^^^^^ ^^^^^é^^^^ Once the daily ketogenic units have been determined, the daily fat requirement is determined: ^^!. ^^^^^ ^^^ = ^^^^ ^^^^^é^^^^ × ^^^^^^^ ^^^^^é^^^^^Once the daily fat requirement has been determined, the daily carbohydrate requirement is determined: ^^!. ^^^^ ^^^ = ^^^^^^^ ^^^^^é^^^^^ ^^^^^^^ − ^^!. ^^^^.The user's daily protein requirement is determined according to the daily requirement recommendations as explained above. e.providing the user (20) with the food formula (11) wherein the food formula (11) comprises a caloric intake between 5 and 10 kcal per gram and a ketogenic ratio selected from 1:1, 2:1, 3:1 or 4:1; To facilitate the user entering a ketogenic state or when the user's health conditions require it, for example, users with difficulty in ingesting food, a food formula (11) can be provided to the user as part of the personalized nutrition method. The food formula (11) can have a 1:1, 2:1, 3:1 or 4:1 ketogenic ratio. The selection of the ketogenic ratio of the food formula (11) depends on the particular conditions of the user, their health status and the objectives of the ketogenic diet. In one embodiment of the disclosure the ketogenic ratio of the food formula (11) is 4:1.

[0019] Page 16 of 33 f. calculate the necessary caloric intake from the food formula (11) in step e) according to the percentage of the food formula (11) selected in step b); Once the percentage of intake of the food formula (11) has been selected in step (b), the specific caloric intake that this formula must provide to the user is calculated. This calculation is based on the caloric density of the food formula, which ranges from 5 to 10 kcal per gram, depending on the specific composition adapted to the user. To perform this calculation, the total amount of daily calories needed, determined in step (a), is multiplied by the percentage of the diet to be covered by the food formula, obtained in step (b).For example, if it has been decided that the food formula will constitute 40% of the user's daily caloric intake and the total daily calories required is 2000 kcal, then the caloric intake of the food formula would be: 2000 kcal×0.40=800 kcal If the chosen food formula contains 700 kcal per 100 grams, the necessary amount of formula would be calculated as follows: 800 &^^^ &^^^= 114 ^ ^^ )ó^* ^^ ^^^^+^*^^^*^^^^700100 ^ In this example you can see that the calculation provides the exact amount of food formula that must be consumed to comply with the established nutritional plan, thus ensuring accuracy in the administration of the ketogenic diet. g. Calculate the amount of food formula (11) from step e) necessary to provide the caloric intake in step f).After establishing the calorie intake required by the formula in step (f), the exact amount of formula the user needs to consume daily is calculated. This calculation is based on the specific caloric density of the formula (for example, in the previous example, 700 kcal per 100 grams was used) and the total calorie intake required by the formula.

[0020] Page 17 of 33 To determine the total amount of formula to be consumed, the total daily caloric requirement of the formula (calculated in step f) is divided by the caloric density of the formula. Additionally, the total amount must be adjusted based on the number of daily feedings, which is defined according to the user’s tolerance and their medical or dietary needs. If, for example, it is determined that the user must divide their intake into three daily feedings, the total amount of formula is divided by the number of feedings to determine how much formula to consume in each feeding. The choice of the number of daily feedings is adapted to the user’s ability to ingest the formula throughout the day and their dietary preferences or restrictions, thus ensuring adherence to the nutritional regimen and the effectiveness of the treatment. h. Calculate the final ketogenic rate according to the dietary combination of food formula (11) and food diet (12) selected.Finally, the final ketogenic rate is calculated according to the ketogenic rates of the food formula (11) and food diet (12) selected and the intake percentage of a food formula (11) and the percentage of a food diet (12) selected in step b). This final ketogenic rate is taken into account to carry out a re-evaluation of the ketogenic rate from the food diet according to the patient's tolerance to the ketogenic diet and with changes in his health condition. Blood ketone body analysis makes it possible to determine whether the user has entered ketosis. If the user has entered ketosis and does not have considerable side effects, the same ketogenic rate can be maintained with continuous monitoring. If the user has entered ketosis, the final ketogenic rate can be adjusted by adjusting the percentage of food formula (12) to reduce side effects of the diet.In order to maintain the ketogenic state, the food formula (11) comprises between 15% and 25% of C8 and C10 medium chain triglycerides of the total fatty acids. The food formula (11) may comprise between 10 and 20 grams of C8 and C10 medium chain triglycerides per 100 grams of food formula (12). C8 and C10 medium chain triglycerides are fatty acids that have 8 or 10 carbon atoms in their molecular structure. These medium chain fatty acids are particularly beneficial in a ketogenic diet because they are metabolized from.

[0021] Page 18 of 33 faster and more efficiently compared to long-chain fatty acids. Medium-chain triglycerides, including C8 and C10 medium-chain fatty acids, can provide a quick source of energy for the body and can help maintain the state of ketosis. The medium-chain triglycerides in the food formula (11) can come from fractionated coconut oil. These are in particular capric acid and caprylic acid. The food formula (11) can also comprise long-chain triglycerides from palm oil. In one embodiment of the disclosure, the method comprises readjusting the amount of food formula (11) each week according to the patient's tolerance to the ketogenic diet. The ketogenic diet may have side effects on the user, in order to lessen these effects or make them more tolerable to the user,In one embodiment of the disclosure, the food formula can be provided at 30% in the first week, 50% in the second week, 70% in the third week, and 100% of the selected food formula percentage in the fourth week. These percentages can be adjusted according to the user's tolerance to the ketogenic diet. In one embodiment of the disclosure, and referring to FIG. 2, the personalized nutrition method for inducing a ketogenic state is executed on a computing unit (30),the method executed in the computing unit (30) comprises: a) receiving in a computing unit (30) physiological data (40) of a user (20) and determining a daily caloric intake data (41) necessary for the user (20) by means of a first analysis process (50); b) determining a percentage intake data of a food formula (42) and a percentage data of a food diet (43) to be used in such a way that the sum of both percentages is equal to 100% of the total daily intake required; c) determining a ketogenic rate data (44) from the food diet of the user (20); d) determining a macronutrient data (45) necessary to induce a ketogenic state according to the ketogenic rate from the food diet selected in step c), and the percentage intake of the food diet of step b) by means of a second analysis process (51);

[0022] Page 19 of 33 e) providing the user (20) with the food formula (11) wherein the food formula comprises a caloric intake between 5 and 10 kcal per gram and a ketogenic rate (14) selected from 1:1, 2:1, 3:1 or 4:1; f) calculating data on the necessary caloric intake from the food formula (46) of step e) according to the percentage of the food formula selected in step b) and calculating data on the amount of food formula (47) of step e) necessary to provide the caloric intake of step f) by executing a third analysis process (52) in the computing unit; g) calculating data in the computing unit the final ketogenic rate (48) according to the dietary combination of food formula and food diet selected. Particularly, the method of the present disclosure processes physiological data (40) of a user (30).Physiological data may include body weight, body composition, physical activity level, health status, basal metabolism, blood glucose, ketones, the user's particular nutritional needs, or combinations of the foregoing. In this disclosure, data is understood to mean a symbolic representation that may be numeric, alphabetic, algorithmic, logical, and / or vector that encodes information. Data may have a structure or frame composed of blocks of characters or bits that represent different types of information. Each block is made up of character strings, numbers, logical symbols, among others. Data may also consist solely of bits (strings in binary language), consist of characters formed one by one by a combination of bits, consist of fields, records, or tables made up of fields and records, or consist of data exchange files (formats such as CSV, JSON, XLS, among others).Additionally, a piece of data can be a matrix of n rows by m columns. A piece of data can contain multiple pieces of data. For example, when the data is frame-structured, the frame can have a block of identifying characters, generally known as a header, which contains information related to a computing device or processor that sends the data, and it can also contain information related to a computing device or processor that receives the data. Preferably, if the data is in frame format, the frame contains blocks associated with layers according to the OSI reference model.

[0023] Page 20 of 33 Likewise, the frame may have a block of tail characters (or simply tail), or "tail" in English, which allows to identify a computing unit or server that is the end of the data, that is, after that block there is no longer information contained in the data previously identified by the computing unit or server with the "header". In addition, the data has between the "header" block and the "tail" block one or more blocks of characters that represent statistics, numbers, descriptors, words, letters, logical values ​​​​(e.g. Booleans) and combinations of these. The computing unit (30) is a device that allows to process data coming from an external element, for example, from devices for collecting physiological data of the user (20).The computing unit (21) analyzes the data that it can send to an external element and carries out actions such as generating data, for example, the macronutrient data necessary to enter a ketogenic state. The data generated by the computing unit can be stored in memory units, transmitted by means of communications modules or displayed on display devices as will be explained later. | The computing unit (30) can be selected from the group consisting of: microcontrollers (v.gr PSOC 4BLE), microprocessors, DSCs (Digital Signal Controller), FPGAs (Field Programmable Gate Array), CPLDs (Complex Programmable Logic Device), ASICs (Application Specific Integrated Circuit), SoCs (System on Chip), PSoCs (Programmable System on Chip), computers, servers, tablets, cell phones, smart phones, signal generators and computing units, processing units or processing modules known to a person of ordinary skill in the art and combinations thereof. In one embodiment of the disclosure, the computing unit (30) is a processor.On the other hand, the computing unit (30) may include a communications module or communications circuit with one or more connection ports configured to access a communications network, for example, a wired network, a wireless network and combinations thereof. Examples of communications networks may be Internet networks, VPN networks, LAN networks, WAN networks, other equivalent communications networks and.

[0024] Page 21 of 33 similar known to a person of ordinary skill in the art, and combinations thereof. In the examples of wired communications modules, they may have a wired connection port that allows communication with external devices through a communications bus, which is selected, among others, from the group consisting of I2C (from the acronym for IIC Inter-Integrated Circuit), CAN (for the acronym in English for Controller Area Network), Ethernet, SPI (for the acronym in English for Serial Peripheral Interface), SCI (for the acronym in English for Serial Communication Interface), QSPI (for the acronym in English for Quad Serial Peripheral Interface), 1-Wire, WO2021006276A1B (for the acronym in English for Domestic Digital Bus), Profibus and others known to a person of ordinary skill in the art, and combinations thereof.Examples of wireless communication modules use a wireless communication technology selected from the group consisting of Bluetooth, WiFi, Radio Frequency RFID (Radio Frequency Identification), UWB (Ultra Wide B-and), GPRS, Konnex or KNX, DMX (Digital MultipleX), WiMax, IR (infrared) and equivalent wireless communication technologies that are known to a person of ordinary skill in the art and combinations thereof. In any embodiment of the system of the present disclosure, the computing unit (30) may be connected to a memory module, wherein the memory module may be configured to store user physiological data or macronutrient data necessary to enter a ketogenic state.In the present disclosure, a memory module or memory register will be understood as a hardware element that includes, but is not limited to, RAM memories (cache memory, SRAM, DRAM, DDR), ROM memory (Flash, Cache, hard drives, SSD, EPROM, EEPROM, removable ROM memories (e.g. SD (miniSD, microSD, etc.), MMC (MultiMedia Card), Compact Flash, SMC (Smart Media Card), SDC (Secure Digital Card), MS (Memory Stick), among others)), CD-ROM, digital versatile discs (DVD for Digital Versatile Disc) or other optical storage, magnetic cassettes, magnetic tapes, storage or any other medium that can be used to store information and that can be accessed by a computing unit.

[0025] Page 22 of 33 processing unit, or processing module. Instructions, data structures, and software modules are generally incorporated into memory modules. Some examples of data structures are: a text sheet, a spreadsheet, or a database. Example 1 A method for calculating technified ketogenic therapy was designed to induce a ketogenic state in a user. a) Determine the user's daily caloric intake (10) required (20): It was determined that the user is a user with no particular health conditions, 40 years old, with a moderate activity level, and weighing 80 kg. Based on the above, the user's caloric requirement is 39 kcal per kilogram or 3,120 calories. b) Determine a percentage of food formula intake (11) and a percentage of food diet (12): The user has no particular health conditions and is starting the personalized nutrition method.According to the above, it was determined that the selected percentage is 30% of food formula (11) and 70% of food diet (12). c) Select a ketogenic rate (13) from the user's food diet (20): The user does not have particular health conditions or particular nutritional requirements. According to the above, the ketogenic rate from the selected food diet is 2:1. d) Determine the macronutrients necessary to induce a ketogenic state according to the percentage from the food diet (12): and the ketogenic rate from the food diet (13) - Calculation of ketogenic units value:

[0026] Page 23 of 33 ^^^^^ ^^^^^ ^^^^^é^^^^ ^^^^^^^^ ^^^^^é^^^^^ = ^ ^^^ ^ 1 ^ ^^ ^^^^^ ^ × ^^^^ ^^^^^é^^^^ ^+ ^^^ 1 ^ ^^ ^^^^ + ^^^^. 1 g of fat = 9 calories 1 g of protein + carbohydrate. = 4 calories Ketogenic unit value = (9 x 2.1) + 4 = 22.9 - Calculation of daily ketogenic units ^^^^^^ ^^^ó^^^^ ^^^^^^^ ^^^^^^^^ ^^^^^é^^^^^ ^^^^^^ = ^^^^^ ^^ ^^ ^^^^^ ^^^^^é^^^^ Daily calorie intake 3120 calories 70% Daily calorie intake: 2184 calories Daily Ketogenic Units = 2184 / 22.9 = 95.4 - Calculation of daily fat requirement ^^! ^^^*^^^^^ ^^ ^^^^^ ^ ^ ^ =^^^^ ^^^^^é^^^^ × ^^^. ^^^^^. ^^^^^^^Ketogenic Rate = 2.1 Daily Ketogenic Units = 95.4 Fat Requirement = 2.1 x 95.4 = 200.3 grams - Daily Carbohydrate Requirement Calculation ^^!. ^^^^ ^^^ = ^^^^^^^ ^^^^^é^^^^^ ^^^^^^^ − ^^! ^^^*^^^^^ ^^^^.Daily Ketogenic Units = 95.4 Protein Requirement = According to the Recommended Dietary Allowance in Table 4, the protein requirement is 1.1 grams per kilogram per day 80 kg X 1.1 grams / kg day = 88 g

[0027] English: Page 24 of 33 To determine the protein requirement from the food diet, the grams of protein in the food formula are calculated and subtracted from the daily protein requirement. Daily protein requirement = 88 g – 19 g (protein intake in 131 g of food formula) = 69 g Daily carbohydrate requirement = 95.4 – 69 = 26.4 g In summary, the following are required: 200.3 grams of fat / day 69 grams of protein / day 26.4 grams of carbohydrate per day e) provide the user (20) with the food formula (11) where the food formula (11) comprises a caloric intake between 5 and 10 kcal per gram and a ketogenic rate (14) selected from 1:1, 2:1, 3:1 or 4:1; The user is provided with a 4:1 ketogenic ratio formula to reduce the amount of formula and the number of feedings required.f) calculate the necessary caloric intake from the food formula (11) in step e) according to the percentage of the food formula (11) selected in step b); According to step b) 30% of food formula (11) was selected. The daily caloric intake is 3120 calories. 30% of this total must be administered with the food formula. Daily caloric intake (10) required by the user (20): 3120 x 30% = 936 Calories.

[0028] Page 25 of 33 g) calculate the amount of food formula (11) from step e) needed to provide the caloric intake from step f); Each 100 grams of food formula contains 716 calories. Therefore, 936 / 7.16 = 131 grams of food formula (11) are required per day. h) calculate the final ketogenic rate (14) according to the dietary combination of food formula (11) and food diet (12) selected. The final ketogenic rate is calculated using the percentages of food formula and food diet. In this case, with 30% food formula and 70% food diet, the final ketogenic ratio is 2.6:1. It should be understood that the present disclosure is not limited to the modalities described and illustrated, since, as will be evident to a person skilled in the art, there are possible variations and modifications that do not depart from the spirit of the invention, defined by the following claims.

[0029] Page 26 of 33

Claims

CLAIMS 1. A method for calculating technified ketogenic therapy to induce a ketogenic state in a user (20), the method comprising: a) determining a daily caloric intake (10) required by the user (20); b) determining a percentage of intake of a food formula (11) and a percentage of a food diet (12) to be used such that the sum of both percentages is equal to 100% of the total daily intake required; c) selecting a ketogenic rate (13) from the food diet (12) of the user (20); d) determining macronutrients required to induce a ketogenic state according to the ketogenic rate from the food diet (13) selected in step c), and the percentage of intake of the food diet (12) in step b);e) providing the user (20) with the food formula (11) wherein the food formula (11) comprises a caloric intake between 5 and 10 kcal per gram and a ketogenic rate (14) selected from 1:1, 2:1, 3:1 or 4:1; f) calculating the necessary caloric intake from the food formula (11) of step e) according to the percentage of the food formula (11) selected in step b); g) calculating the amount of food formula (11) of step e) necessary to provide the caloric intake of step f);(h) calculating the final ketogenic rate (14) according to the combination of ketogenic rates of food formula (11) and food diet (12) selected and the intake percentage of a food formula (11) and the percentage of a food diet (12) selected in step b).

2. The method of Claim 1, wherein the ketogenic rate (13) from the food diet (12) is 2:

1.

3. The method of Claim 1, wherein the ketogenic rate (14) from the food formula (11) is 4:1.; Page 27 of 33 4. The method of Claim 1, wherein the percentage of intake of food formula (11) is selected between 30% and 100%.

5. The method of Claim 1, wherein the amount of food formula (11) is provided 30% in the first week, 50% in the second week, 70% in the third week and 100% in the fourth week.

6. The method of Claim 1, wherein the food formula (11) comprises between 15% and 25% of C8 and C10 medium chain triglycerides of the total fatty acids.

7. The method of Claim 1, wherein the food formula (11) comprises between 10 g and 20 g of C8 and C10 medium chain triglycerides per 100 g of food formula (11).

8. The method of Claim 1, wherein the food formula (11) comprises long chain triglycerides of palm oil, and medium chain triglycerides of fractionated coconut oil which are capric acid and caprylic acid. 9.The method of Claim 1, wherein the food formula (11) has a macronutrient composition of between 1 and 4 grams of carbohydrates per 100 grams, between 12 and 16 grams of protein per 100 grams and between 65 and 80 grams of fat per 100 grams. Page 28 of 33

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