Allergen-reducing agent, synthetic resin composition, allergen-reducing coating material, and allergen-reducing product

Abstract

The present invention provides an allergen-reducing agent that is less likely to whiten even when water comes into contact therewith. This allergen-reducing agent comprises (A) an organic acid having a solubility in water at 25°C of less than 100 g / L and (B) an organic acid having a solubility in water at 25°C of 100 g / L or more. Due to this feature, the allergen-reducing agent not only has excellent allergen-reducing effects, but also has excellent whitening resistance so as not to cause the whitening of the surface of an allergen-reducing product containing the allergen-reducing agent even when water comes into contact with the surface of the allergen-reducing product.

Description

Allergen reducing agent, synthetic resin composition, allergen reducing paint and allergen reducing product

[0001] The present invention relates to an allergen-reducing agent, a synthetic resin composition, an allergen-reduced paint, and an allergen-reduced product.

[0002] In recent years, many allergic diseases such as atopic dermatitis, bronchial asthma, and allergic rhinitis have become a problem. The main causes of these allergic diseases are mites that live in homes, particularly allergens (Dermatophagoides pteronyssinus, Dermatophagoides typhimurium) that are abundant in house dust, and cedar pollen allergens (Cryj1, Cryj2) that are airborne in large quantities mainly in spring.

[0003] Therefore, there is a need for a technology that can remove allergens from living spaces or inactivate them by denaturing them.

[0004] Patent Document 1 discloses, as an allergen reducing agent, particles for removing allergens, which are made of a vinyl polymer having 0.5 to 12 mmol / g of H-type carboxyl groups and a crosslinked structure.

[0005] JP 2009-160563 A

[0006] In daily life, the surfaces of articles containing allergen-reducing agents are routinely cleaned by wiping with water, and there are also cases where water gets splashed onto the surfaces of the articles during use.

[0007] The inventors have discovered a problem in that when a coating film containing an allergen reducing agent containing a specific organic acid is applied to the surface of an article, if the coating film is exposed to water as described above, the coating film will whiten, which can damage the appearance of the article.

[0008] The present invention provides an allergen denaturing agent that is less likely to cause whitening on the product surface even when water is applied.

[0009] The allergen reducing agent of the present invention is characterized by comprising an organic acid (A) having a solubility in water at 25°C of less than 100 g / L and an organic acid (B) having a solubility in water at 25°C of 100 g / L or more.

[0010] The resin composition of the present invention is characterized by containing the allergen reducing agent and a synthetic resin.

[0011] The allergen-reducing paint of the present invention is characterized by comprising the above-mentioned allergen-reducing agent and a paint.

[0012] The allergen-reduced product of the present invention is characterized by having a substrate and a coating film provided on the surface of the substrate and containing the allergen-reducing agent.

[0013] The allergen reducing agent of the present invention contains an organic acid (A) having a solubility in water at 25°C of less than 100 g / L and an organic acid (B) having a solubility in water at 25°C of 100 g / L or more, and therefore has an excellent allergen reducing effect and also has excellent whitening resistance such that even when water is applied to the surface of an allergen reduced product containing the allergen reducing agent, whitening does not occur on the surface of the allergen reduced product.

[0014] In the numerical ranges described in stages in this specification, the upper or lower limit of a certain numerical range can be arbitrarily combined with the upper or lower limit of another numerical range. In the numerical ranges described in this specification, the upper or lower limit of the numerical range may be replaced with a value shown in an example or a value that can be unambiguously derived from an example. In this specification, a numerical value connected with "to" means a numerical range that includes the numbers before and after "to" as the lower and upper limits.

[0015] The allergen reducing agent of the present invention comprises an organic acid (A) having a solubility in water at 25°C of less than 100 g / L (hereinafter, sometimes simply referred to as "organic acid (A)") and an organic acid (B) having a solubility in water at 25°C of 100 g / L or more (hereinafter, sometimes simply referred to as "organic acid (B)").

[0016] The total content of the organic acid (A) and the organic acid (B) is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, and more preferably 99% by mass or more, based on 100% by mass of the allergen reducing agent.

[0017] [Organic Acid (A)] The allergen denaturing agent contains, as an active ingredient, an organic acid (A) having a solubility in water at 25°C of less than 100 g / L.

[0018] The solubility of the organic acid (A) is less than 100 g / L, preferably 80 g / L or less, more preferably 60 g / L or less, more preferably 40 g / L or less, and more preferably 30 g / L or less. The solubility of the organic acid (A) is preferably 0 g / L or more.

[0019] The organic acid (A) is sufficient as long as it has a solubility in water at 25°C of less than 100 g / L, and since this improves the whitening resistance of the allergen reducing agent, the molecular weight is preferably 1,000 or less, more preferably 800 or less, and even more preferably 600 or less.

[0020] In the present invention, the solubility (g / L) of an organic acid in water at 25°C refers to the mass (g) of the organic acid that can be dissolved in 1 L of water, or the mass (g) of the organic acid dissolved in 1 L of water in a saturated aqueous solution at 25°C. Specifically, the solubility of an organic acid in water at 25°C refers to a value measured at 25°C in accordance with OECD Chemicals Testing Guideline No. 105 (Water Solubility).

[0021] The organic acid (A) preferably has a carboxy group (-COOH), a sulfo group (-SOH), a phosphonic acid group [-P(=O)(OH)], or a phosphate group [-OPO(OH)] in its molecule, and may have only one of these functional groups or may have multiple types of functional groups. Because the organic acid (A) can improve the allergen reduction effect and whitening resistance, it preferably has a carboxy group (-COOH), a sulfo group (-SOH), or a phosphate group [-OPO(OH)] in its molecule, more preferably a carboxy group (-COOH) or a sulfo group (-SOH), and even more preferably a carboxy group (-COOH).

[0022] The organic acid (A) preferably has, in its molecule, a plurality of functional groups selected from the group consisting of a carboxy group (-COOH), a sulfo group (-SO3H), a phosphonic acid group [-P(=O)(OH)2], and a phosphate group [-OPO(OH)2], more preferably a carboxy group among the plurality of functional groups, and even more preferably a plurality of carboxy groups. When the organic acid (A) has a plurality of the above functional groups, the allergen reduction effect and whitening resistance can be improved.

[0023] The organic acid (A) is not particularly limited as long as its solubility in water at 25°C is less than 100 g / L, and examples thereof include iminodiacetic acid (24.3 g / L), fumaric acid (6.3 g / L), sulfanilic acid (10.8 g / L), phthalic acid (6.25 g / L), terephthalic acid (0.017 g / L), isophthalic acid (0.1 g / L), diethylenetriaminepentaacetic acid (DTPA, 4.8 g / L), 1,3-propanediamine-N,N,N',N'-tetraacetic acid (PDTA, 9.08 g / L), alginic acid (solubility: 0 g / L), sebacic acid (solubility: 0.25 g / L), dodecanedioic acid (solubility: 0 g / L), isophthalic acid (solubility: 0.13 g / L), methylenedisalicylic acid (solubility: 0 g / L), cis-Δ4-tetrahydrophthalic acid (solubility: 0 g / L). pelargonic acid (solubility: 0.28 g / L), capric acid (solubility: 0.15 g / L), lauric acid (solubility: 0.0048 g / L), myristic acid (solubility: 0 g / L), palmitic acid (solubility: 0 g / L), stearic acid (solubility: 0 g / L), myristoleic acid (solubility: 0 g / L), oleic acid (solubility: 0 g / L), and ricinoleic acid (solubility: 0 g / L) are examples. Among these, iminodiacetic acid (24.3 g / L), fumaric acid (6.3 g / L), sulfanilic acid (10.8 g / L), phthalic acid (6.25 g / L), terephthalic acid (0.017 g / L), isophthalic acid (0.1 g / L), diethylenetriaminepentaacetic acid (DTPA, 4.8 g / L), and 1,3-propanediamine-N,N,N',N'-tetraacetic acid (PDTA, 9.08 g / L) are preferred. The solubility shown in parentheses is the solubility of the organic acid (A) in water at 25°C. The organic acid (A) may be used alone or in combination of two or more.

[0024] [Organic Acid (B)] The allergen denaturing agent contains, as an active ingredient, an organic acid (B) having a solubility in water at 25°C of 100 g / L or more.

[0025] The organic acid (B) is sufficient as long as it has a solubility in water at 25°C of 100 g / L or more, and since this improves the whitening resistance of the allergen reducing agent, it preferably has a molecular weight of 1,000 or less, more preferably 800 or less, and even more preferably 400 or less.

[0026] The solubility of the organic acid (B) in water at 25° C. is 100 g / L or more, preferably 200 g / L or more, more preferably 300 g / L or more, and even more preferably 400 g / L or more.

[0027] The solubility of the organic acid (B) in water at 25° C. is preferably 3000 g / L or less, more preferably 2500 g / L or less, more preferably 2000 g / L or less, more preferably 1600 g / L or less, and more preferably 1200 g / L or less. When the solubility of the organic acid (B) in water at 25° C. is 3000 g / L or less, even when the allergen denaturing agent comes into contact with water, excessive elution of the allergen denaturing agent is reduced, and the allergen denaturing agent has excellent water resistance.

[0028] The organic acid (B) preferably has a carboxy group (-COOH), a sulfo group (-SOH), a phosphonic acid group [-P(=O)(OH)2], or a phosphate group [-OPO(OH)2] in its molecule, and may have only one of these functional groups or may have multiple types of functional groups. The organic acid (B) preferably has a carboxy group (-COOH), a sulfo group (-SOH), or a phosphonic acid group [-P(=O)(OH)2] in its molecule, as this can improve the allergen reduction effect and whitening resistance.

[0029] The organic acid (B) preferably has, in its molecule, a plurality of functional groups selected from the group consisting of a carboxyl group (-COOH), a sulfo group (-SO3H), and a phosphonic acid group [-P(=O)(OH)2]. When the organic acid (B) has a plurality of such functional groups, the allergen reduction effect and whitening resistance can be improved.

[0030] The organic acid (B) is not particularly limited as long as it has a solubility in water at 25°C of 100 g / L or more, and examples thereof include citric acid (1166 g / L), phenylphosphonic acid (381 g / L), benzenesulfonic acid (725 g / L), and malic acid (558 g / L), with citric acid (1166 g / L), phenylphosphonic acid (381 g / L), and benzenesulfonic acid (725 g / L) being preferred. The solubility shown in parentheses is the solubility of the organic acid (B) in water at 25°C. The organic acid (B) may be used alone or in combination of two or more.

[0031] The sum of the solubility of organic acid (A) in water at 25°C and the solubility of organic acid (B) in water at 25°C (hereinafter sometimes referred to as the "total solubility of organic acids (A) and (B)") is preferably 300 g / L or more, more preferably 350 g / L or more, and even more preferably 400 g / L or more. The sum of the solubility of organic acid (A) in water at 25°C and the solubility of organic acid (B) in water at 25°C is preferably 1250 g / L or less, more preferably 1200 g / L or less. When the total solubility of organic acids (A) and (B) is within the above range, the allergen reducing agent has superior allergen reducing effect and whitening resistance.

[0032] In the allergen reducing agent, the content of the organic acid (B) is preferably 100 parts by mass or more, more preferably 120 parts by mass or more, more preferably 130 parts by mass or more, more preferably 140 parts by mass or more, and more preferably 150 parts by mass or more, per 100 parts by mass of the organic acid (A). In the allergen reducing agent, the content of the organic acid (B) is preferably 2000 parts by mass or less, more preferably 1800 parts by mass or less, more preferably 1700 parts by mass or less, more preferably 1600 parts by mass or less, and more preferably 1500 parts by mass or less, per 100 parts by mass of the organic acid (A). When the content of the organic acid (B) is within the above range, the allergen reducing agent has excellent allergen reducing effect and whitening resistance.

[0033] [Allergen-reducing agent] The allergen-reducing agent can be produced by mixing organic acids (A) and (B) by a commonly used method. By containing both organic acids (A) and (B), the allergen-reducing agent achieves both excellent allergen-reducing effect and whitening resistance.

[0034] Here, the allergen reducing agent refers to an agent having an allergen reducing effect. The allergen reducing effect can be determined by measuring the allergen reduction rate for cedar pollen allergen (Cryj1) or mite allergen (Derf1) as described below, and if the allergen reduction rate for at least either allergen is 60% or more, the agent can be determined to have an allergen reducing effect.

[0035] An allergen-reducing paint is prepared by adding 90 parts by weight of binder resin (solid content) to 10 parts by weight of allergen-reducing agent. Next, a polyester film is prepared as a substrate. The allergen-reducing paint is applied to one side of the substrate, and then dried or cured to produce an allergen-reducing product with a coating film 18 μm thick formed on one side.

[0036] The lyophilized powders of the allergens were dissolved separately in purified water to prepare an aqueous allergen solution containing 10 μg / mL of the allergen. Then, phosphate-buffered saline (pH 7.4, hereinafter referred to as "PBS-T") containing 0.05 w / v% polysorbate 20 was added to the aqueous allergen solution and mixed uniformly to prepare an aqueous allergen solution containing 15 ng / mL of the allergen.

[0037] The allergen-reduced product is cut into a flat square with sides of 5 cm, 0.4 mL of the allergen solution is dropped onto the coating, and the product is then covered with a flat square polyethylene film with sides of 4 cm and left to stand for 24 hours at 25°C to prepare a test solution. Next, the amount of allergen present in the test solution, W1 (ng / mL), is measured using the measurement reagent.

[0038] A blank product with a coating film formed on one side is prepared in the same manner as above, except that a binder resin is used as the blank paint instead of the allergen-reduced paint. The amount of allergen present in the test solution, W0 (ng / mL), is measured in the same manner as above, except that the blank product is used instead of the allergen-reduced product. The allergen reduction rate (%) is calculated using the following formula: Allergen reduction rate (%) = 100 - (W1 / W0) x 100

[0039] Allergens targeted by allergen reducing agents include animal allergens such as house dust mite allergens (Der1, Der2) and allergens caused by dogs and cats (Canf1, Feld1), airborne cedar pollen allergens (Cryj1, Cryj2), and plant allergens such as pollen. Particularly effective animal allergens include allergens from mites (mites are organisms of the Arthropoda class - order Acari, and are divided into seven main suborders: dorsal stigmata represented by Dermestida, tetrastigmata represented by hard mites, posterior stigmata represented by Ixodes ovatus and Ornithoides pulcherrimus, middle stigmata represented by house mites and Passer mites, anterior stigmata represented by Lunanese Cheyletida and Tarsoria cruzi, house dust mites such as Dermatophagoides farinae, astigmata represented by Tyrophagus putrescentiae, and cryptostigmata represented by Ornithoides nigricans and Neospora nigricans). However, it is particularly effective against house dust mites, which are abundant in house dust, especially in bedding, and cause allergic diseases.

[0040] The cedar pollen allergen (Cryj1) may be, for example, a product commercially available from ITEA under the trade name "Cedar Pollen Extract, Code 10103." The mite allergen (Derf1) may be, for example, a product commercially available from ITEA under the trade name "Mite Allergen Extract, Code 10102."

[0041] The cedar pollen allergen measurement kit may be, for example, a measurement kit commercially available from ITEA under the product name "Cedar Pollen Allergen (Cryj1) ELISA Kit, Code 10204."The mite allergen measurement kit may be, for example, a measurement kit commercially available from ITEA under the product name "Mite Allergen (Derf1) ELISA Kit, Code 10205."

[0042] The allergen reduction rate of the allergen reducing agent is preferably 65% ​​or more, more preferably 70% or more, more preferably 80% or more, more preferably 85% or more, more preferably 90% or more, and more preferably 95% or more.

[0043] Next, the usage of the allergen-reducing agent will be described. The allergen-reducing agent is used, for example, by being contained in a substrate to which an allergen-reducing effect is to be imparted, thereby constituting an allergen-reduced product. The substrate containing the allergen-reducing agent exhibits an allergen-reducing effect as an allergen-reduced product. The form in which the allergen-reducing agent is contained in the substrate is not particularly limited, and examples include a form in which the allergen-reducing agent is mixed into the substrate, a form in which the allergen-reducing agent is attached to the surface of the substrate, and a form in which the allergen-reducing agent is kneaded into the substrate.

[0044] The allergen-reducing agent can be attached to the surface of a substrate by dissolving or dispersing the allergen-reducing agent in a solvent to prepare an allergen-reducing liquid, and then applying the allergen-reducing liquid to the substrate. The allergen-reducing liquid may contain additives such as solvents, oils, emulsions, and suspending agents, as needed.

[0045] Examples of the solvent include water (preferably ion-exchanged water), alcohols (methyl alcohol, ethyl alcohol, propyl alcohol, etc.), hydrocarbons (toluene, xylene, methylnaphthalene, kerosene, cyclohexane, etc.), ethers (diethyl ether, tetrahydrofuran, dioxane, etc.), ketones (acetone, methyl ethyl ketone, etc.), and amides (N,N-dimethylformamide, etc.), with water or alcohols being preferred.

[0046] The content of the allergen-reducing agent in 100% by mass of the allergen-reducing liquid is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and more preferably 1% by mass or more. The content of the allergen-reducing agent in 100% by mass of the allergen-reducing liquid is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less.

[0047] The substrate into which the allergen reducing agent is to be incorporated is not particularly limited as long as it is capable of incorporating the allergen reducing agent, and examples include synthetic resin molded bodies, paints, wallpaper, decorative sheets, flooring materials, fibers, textile products (woven fabrics, nonwoven fabrics, knitted fabrics), interior and interior materials for vehicles (for example, cars, airplanes, ships, etc.) (seats, child seats, and foams that constitute these, etc.), kitchenware, baby products, and architectural interior materials.

[0048] The building interior materials are not particularly limited, and examples thereof include flooring materials, wallpaper, ceiling materials, paints, doorknobs, switches, switch covers, wax, and the like.

[0049] The vehicle interior goods and materials are not particularly limited, and examples thereof include seats, child seats, seat belts, car mats, seat covers, doors, ceiling materials, floor mats, door trim, instrument panels, consoles, glove boxes, handrails, and the like.

[0050] The synthetic resin constituting the synthetic resin molded body is not particularly limited, and examples thereof include thermoplastic resins (e.g., polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyvinyl acetate, polyurethane, Teflon (registered trademark), acrylonitrile butadiene styrene resin, acrylonitrile styrene resin, acrylic resin, polyvinyl alcohol, polyamide, polyacetal, polycarbonate, modified polyphenylene ether, polyester, polyethylene terephthalate, polybutylene terephthalate, cyclic polyolefin, polyphenylene sulfide, polytetrafluoroethylene, polysulfone, polyethersulfone, polyarylate, polyether ether ketone, thermoplastic polyimide, polyamide imide, etc.), thermosetting resins (e.g., phenolic resin, epoxy resin, melamine resin, urea resin, unsaturated polyester resin, alkyd resin, silicone resin, polyurethane, thermosetting polyimide, etc.). The synthetic resins may be used alone or in combination of two or more.

[0051] The allergen-reducing agent may be kneaded into the synthetic resin. Even when the allergen-reducing agent is kneaded into the synthetic resin, the allergen-reducing agent is effectively present in a protruding state on the surface of the resulting allergen-reduced product (molded article), and the allergen-reduced product exhibits excellent allergen-reducing effects.

[0052] A method for kneading an allergen-reducing agent into a synthetic resin involves mixing the allergen-reducing agent with a raw synthetic resin to prepare a resin composition, and then using this resin composition to obtain an allergen-reduced product of a desired shape as a molded article by a general-purpose synthetic resin molding method. Examples of general-purpose synthetic resin molding methods include extrusion molding, injection molding, and blow molding. A synthetic resin and an allergen-reducing agent may be mixed to prepare a synthetic resin molding masterbatch, which may then be mixed with the raw synthetic resin to produce an allergen-reduced product as a molded article by a general-purpose synthetic resin molding method.

[0053] The content of the allergen reducing agent in 100% by mass of the resin composition is preferably 1% by mass or more, more preferably 3% by mass or more, and more preferably 5% by mass or more. The content of the allergen reducing agent in 100% by mass of the resin composition is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less.

[0054] The content of the allergen reducing agent in 100% by mass of the synthetic resin molding masterbatch is preferably 20% by mass or more, more preferably 30% by mass or more, and more preferably 50% by mass or more. The content of the allergen reducing agent in 100% by mass of the synthetic resin molding masterbatch is preferably 80% by mass or less, more preferably 70% by mass or less, and more preferably 60% by mass or less.

[0055] Allergen-reducing paints can be produced by incorporating an allergen-reducing agent into paint. Conventional paints can be used as the paint, including oil-based paints (e.g., blended paints, oil varnishes, etc.), cellulose paints, and synthetic resin paints. The paint also includes photocurable paints that polymerize upon exposure to radiation such as ultraviolet light to produce a binder resin component.

[0056] Paints generally contain a binder resin and a solvent. The solvent is the same as that described above, so a detailed description will be omitted. The paint may contain additives such as pigments, plasticizers, curing agents, extenders, fillers, antioxidants, thickeners, and surfactants, as long as the additives do not impair the paint's physical properties. Examples of methods for preparing an allergen-reducing paint by incorporating an allergen-reducing agent into the paint include a method in which the allergen-reducing agent and the paint are supplied to a dispersing device and mixed uniformly. Examples of dispersing devices include a high-speed mill, a ball mill, and a sand mill.

[0057] Examples of binder resins include urethane-based resins such as one-component urethane resins and two-component urethane resins, silicone-based resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, and epoxy acrylate resins.

[0058] The content of the allergen-reducing agent in 100% by mass of the allergen-reducing paint is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and more preferably 1% by mass or more. The content of the allergen-reducing agent in 100% by mass of the allergen-reducing paint is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less.

[0059] By applying a paint to the surface of the above-mentioned substrate and then providing a coating film containing an allergen-reducing agent on the surface of the substrate (laminated and integrated), an allergen-reducing product having an allergen-reducing effect can be constructed.

[0060] The present invention will be described in more detail using examples, but the present invention is not limited thereto. Specific numerical values ​​of the blending ratio (content ratio), physical property values, parameters, etc. used in the following description can be replaced with the upper limit (a numerical value defined as "equal to or less than") or lower limit (a numerical value defined as "equal to or more than") of the blending ratio (content ratio), physical property values, parameters, etc. described in the "Description of Embodiments" or "Summary of the Problems" section.

[0061] (Examples 1 to 10, Comparative Examples 1 to 3) Allergen reducing agents were prepared by uniformly mixing the organic acids (A) and (B) of the types shown in Table 1 in the predetermined amounts shown in the "Content (parts by mass)" column of Table 1. In Table 1, "diethylenetriaminepentaacetic acid" is represented as "DTPA" and "1,3-propanediamine-N,N,N',N'-tetraacetic acid" is represented as "PDTA."

[0062] For the organic acids (A) and (B) shown in Table 1, the solubility in water at 25°C and the molecular weight are shown in the "Water solubility (g / L)" and "Molecular weight" columns, respectively.

[0063] The whitening resistance and allergen reduction rate of the obtained allergen reducing agent were measured in the following manner, and the results are shown in Table 1.

[0064] (Allergen Reduction Rate) The allergen denaturing agents were subjected to an anti-allergen test using mite allergen (Derf1) and pollen allergen (Cryj1).

[0065] The mite allergen (Derf1) used was a freeze-dried powder of mite allergen (Derf1) (manufactured by Cosmo Bio Co., Ltd., product name "Mite Extract-Df"), and the measurement reagent used was a measurement reagent (manufactured by Nichinici Co., Ltd., product name "Mite Allergen Derf1 Measurement ELISA Kit").

[0066] The cedar pollen allergen (Cryj1) used was a freeze-dried powder of cedar pollen allergen (Cryj1) (manufactured by ITEA, product name "Cedar Pollen Extract"), and the measurement reagent used was a measurement reagent (manufactured by Nichinici, product name "Cedar Pollen Allergen Cryj1 Measurement ELISA Kit").

[0067] An allergen-reducing paint was prepared by adding 90 parts by mass of an ultraviolet-curable acrylic paint (manufactured by Coattec Co., Ltd., product name "AI-N2") to 10 parts by mass of the allergen-reducing agent and uniformly mixing them. Next, a polyester film was prepared as a substrate. One side of this substrate was coated with the allergen-reducing paint to a thickness of 18 μm using a wire bar coater #8, and then ultraviolet light with a wavelength of 365 nm was applied to the coating layer at 25°C using a UV conveyor device (manufactured by iGraphics Co., Ltd., product name "ECS301G1") at an integrated light dose of 500 mJ / cm. 2 The ultraviolet-curable acrylic paint was cured by irradiating the paint so that a coating film having a thickness of 18 μm was formed on one side, thereby producing an allergen-reduced product.

[0068] The freeze-dried powders of the above allergens were dissolved separately in purified water to prepare aqueous allergen solutions containing 10 μg / mL of allergen. PBS-T was then added to the aqueous allergen solutions and mixed uniformly to prepare an allergen solution containing 15 ng / mL of allergen.

[0069] The allergen-reduced product was cut into a 5 cm square shape, 0.4 mL of the allergen solution was dropped onto the coating, and the product was then covered with a 4 cm square polyethylene film and left to stand for 24 hours at 25°C to prepare a test solution. The amount of allergen present in the test solution, W1 (ng / mL), was then measured using the measurement reagent.

[0070] A blank product with a coating film formed on one side was prepared in the same manner as above, except that an ultraviolet-curing acrylic paint (manufactured by Coattec Co., Ltd., product name "AI-N2") was used as the blank paint instead of the allergen-reduced paint. The amount of allergen present in the test solution, W0 (ng / mL), was measured in the same manner as above, except that the blank product was used instead of the allergen-reduced product. The allergen reduction rate (%) was calculated based on the following formula. The results obtained are shown in the "Allergen reduction rate (%)" columns for "mite (Derf1)" and "cedar (Cryj1)" in Table 1. Allergen reduction rate (%) = 100 - (W1 / W0) x 100

[0071] (Whitening Resistance) Allergen-reduced products were prepared in the same manner as in the measurement of the allergen reduction rate. The obtained allergen-reduced products were cut into flat squares with sides of 8 cm to prepare test pieces. A flat square filter paper with sides of 4 cm was placed on the coating film of the test piece, and 0.4 mL of tap water was dropped onto the filter paper and allowed to stand at 25°C for 24 hours. The filter paper and tap water were wiped off, and the test piece was allowed to dry at room temperature for 1 hour.

[0072] Next, the L* value (L1) of the coating film of the test piece was measured using a spectrophotometer (manufactured by Konica Minolta, product name "CM-5"). The L* value (L0) of the coating film of the blank product was also measured in the same manner, and the whitening degree ΔL was calculated based on the following formula. The results obtained are shown in the "Whitening resistance (ΔL)" column of Table 1. Whitening degree ΔL = L1 - L0 L1: L* value of the coating film of the allergen-reduced product L0: L* value of the coating film of the blank product

[0073]

[0074] The allergen-reducing agent of the present invention contains organic acid (A) and organic acid (B), and therefore has an excellent allergen-reducing effect. An allergen-reduced product containing the allergen-reducing agent has excellent whitening resistance, meaning that the surface of the allergen-reduced product does not whiten even when water is applied to the surface. The allergen-reducing agent can be applied to a variety of substrates. The allergen-reducing agent can be used to produce allergen-reduced products that can be used for a variety of purposes.

[0075] (Cross-reference to related applications) This application claims priority to Japanese Patent Application No. 2024-062428, filed on April 8, 2024, the disclosure of which is incorporated herein by reference in its entirety.

Claims

1. An allergen reducing agent comprising an organic acid (A) having a solubility in water at 25°C of less than 100 g / L and an organic acid (B) having a solubility in water at 25°C of 100 g / L or more.

2. The allergen reducing agent according to claim 1, characterized in that it contains 100 parts by mass of the organic acid (A) and 100 to 2000 parts by mass of the organic acid (B).

3. An allergen reducing agent according to claim 1 or 2, characterized in that the molecular weight of the organic acid (A) is 1,000 or less.

4. An allergen reducing agent according to claim 1 or 2, characterized in that the organic acid (A) has a carboxy group or a sulfo group in the molecule.

5. The allergen reducing agent according to claim 1 or 2, characterized in that the organic acid (A) contains at least one organic acid selected from the group consisting of iminodiacetic acid, fumaric acid, sulfanilic acid, phthalic acid, terephthalic acid, isophthalic acid, diethylenetriaminepentaacetic acid, and 1,3-propanediamine-N,N,N',N'-tetraacetic acid.

6. An allergen reducing agent according to claim 1 or 2, characterized in that the organic acid (B) has a carboxyl group, a phosphonic acid group or a sulfo group in the molecule.

7. An allergen reducing agent according to claim 1 or claim 2, characterized in that the organic acid (B) contains at least one organic acid selected from the group consisting of citric acid, phenylphosphonic acid and benzenesulfonic acid.

8. A resin composition comprising the allergen reducing agent according to claim 1 or 2 and a synthetic resin.

9. An allergen-reducing paint comprising the allergen-reducing agent according to claim 1 or 2 and a paint.

10. An allergen-reducing product comprising a substrate and a coating film provided on the surface of the substrate and containing the allergen-reducing agent according to claim 1 or 2.

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