Apparatus for manual implantation of self-thermoregulating magnetic hydrogel

Abstract

Provided is an apparatus for manual implantation of a self-thermoregulating magnetic hydrogel, comprising a needle cylinder (2). The needle cylinder (2) is loaded with a magnetic hydrogel. The needle cylinder (2) comprises a needle head interface (4). An injection implantation needle (6) is mounted on the needle head interface (4). A temperature control unit (5) is mounted at the position of the needle head interface (4). The apparatus for manual implantation of a self-thermoregulating magnetic hydrogel solves the problem of hydrogel curing in a needle channel in the injection process.

Description

A self-temperature-controlled magnetic hydrogel manual implantation device TECHNICAL FIELD

[0001] The present application belongs to the field of medical devices, and particularly relates to a self-temperature-controlled magnetic hydrogel manual implantation device. BACKGROUND

[0002] Since the temperature tolerance of normal cells is higher than that of tumor cells, by heating the tumor tissue to an appropriate temperature (42-45 DEG C), cancer cells can be effectively killed, and the damage to the surrounding normal cells can be effectively controlled, so that the heat therapy is considered to be a more green and safe tumor treatment method compared with chemotherapy and radiotherapy. In the heat therapy method, the magnetic heat therapy method uses the characteristics of the magnetic substance in the alternating magnetic field to heat up and heat, and by implanting or interventional therapy of the magnetic medium into the target area, the magnetic induction heat is used to selectively kill cancer cells, and the normal tissue is not affected, so that the targeted treatment at the organ / tissue level is realized. Compared with the ultrasonic heat therapy method, the magnetic heat therapy method is not affected by the air cavity, bone reflection and bone absorption, compared with the microwave heat therapy method, the magnetic heat therapy method can heat the deep area in the body, and compared with the electric field divergence radio frequency heat therapy method, the magnetic heat therapy method can accurately and uniformly heat the tumor area. In the magnetic heat therapy method, the magnetic nano-particles are used as the heating medium, the uniform distribution of the temperature field in the tumor can be realized by using the small particle size of the magnetic nano-particles, and the magnetic nano-particle heat therapy has been clinically successfully treated in prostate cancer, lung cancer and other aspects.

[0003] At present, the traditional syringe is used to inject and implant the magnetic hydrogel, and due to the influence of the human tissue on the inserted needle, the hydrogel is solidified in the needle channel during the injection process. SUMMARY

[0004] In view of the defects of the prior art, the purpose of the present application is to provide a self-temperature-controlled magnetic hydrogel manual implantation device, which solves the problem of solidification of the hydrogel in the needle channel during the injection process.

[0005] The following means are used to achieve the above purpose:

[0006] A self-temperature-controlled magnetic hydrogel manual implantation device, comprising:

[0007] A needle cylinder, the needle cylinder is loaded with magnetic hydrogel;

[0008] The needle cylinder comprises a needle head interface, an injection and implantation needle is installed on the needle head interface, and a temperature control unit is installed at the position of the needle head interface.

[0009] In some embodiments, the temperature control unit is detachably connected with the needle head interface.

[0010] In some embodiments, the temperature control unit comprises a mounting hole with an internal thread, and the mounting hole is threadedly connected with the needle head interface.

[0011] In some of the disclosure, the temperature control unit comprises a semiconductor refrigerator.

[0012] In some of the disclosure, the material of the injection implant needle is a medical non-magnetic metal material; the medical non-magnetic metal material comprises one of titanium alloy, nickel-titanium alloy and cobalt-based alloy.

[0013] In some of the disclosure, the outer wall of the needle cylinder is attached with a heat preservation layer 。

[0014] In some of the disclosure, the heat preservation layer is one of polytetrafluoroethylene and micrometer-level thin ceramic coating.

[0015] In some of the disclosure, the inner wall of the needle cylinder and / or the wall of the channel in the injection implant needle is attached with a hydrophobic layer.

[0016] In some of the disclosure, the hydrophobic layer is one of polytetrafluoroethylene, dihydrofluorescein and silicone resin.

[0017] In some of the disclosure, further comprising: a rotating push rod, the rotating push rod comprises a connecting piece I and a connecting sleeve, one end of the connecting piece I is fixedly installed with a piston, the piston is attached to the inner wall of the needle cylinder, the end of the connecting piece I away from the piston is fixedly connected with the connecting sleeve, the connecting sleeve is partially sleeved on the outer wall of the needle cylinder, the piston of the rotating push rod pushes the magnetic hydrogel in the needle cylinder, so that the magnetic hydrogel loaded in the needle cylinder is injected into the target position through the needle;

[0018] The outer wall of the needle cylinder is provided with a quantitative knob moving along the length direction of the needle cylinder, when the piston of the rotating push rod pushes the magnetic hydrogel in the needle cylinder, until the connecting sleeve of the rotating push rod abuts against the quantitative knob.

[0019] The outer wall of the needle cylinder is provided with an external thread screwing with the quantitative knob;

[0020] The outer wall of the needle cylinder is threadedly connected with the connecting sleeve.

[0021] The present application has at least one of the following beneficial effects:

[0022] 1. Realize self-temperature-control magnetic hydrogel implantation;

[0023] 2. Realize self-temperature-control magnetic hydrogel non-solidification and non-adhesion in the implantation device;

[0024] 3. Realize self-temperature-control magnetic hydrogel implantation quantity accurate control. BRIEF DESCRIPTION OF DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, for those skilled in the art, other drawings can also be obtained based on these drawings without any creative effort.

[0026] Fig. 1 is a schematic diagram of the overall structure in an embodiment;

[0027] Fig. 2 is a schematic diagram of the enlarged structure in an embodiment;

[0028] Fig. 3 is a schematic diagram of the cross-sectional structure in an embodiment. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present application will be described clearly and completely in the following with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without any creative effort fall within the scope of the present application.

[0030] Some commonly used words related to the present application are explained as follows:

[0031] Magnetic hydrogel is prepared by taking hydrogel as a base body and carrying magnetic nanoparticles. The magnetic hydrogel has the characteristics of room-temperature liquid injectable and body-temperature gelation solidification, and can be stably maintained between a specified hyperthermia temperature (42℃-45℃), and will not be liquefied again when being continuously heated after gelation solidification;

[0032] Injectable hydrogel is a water-soluble polymer solution which can be in situ gelled when applied to a target environment (such as human body or porous scaffold). By using this characteristic of hydrogel, the human body can be treated in various ways, for example, the hydrogel is mixed with drugs and biological agents and can be injected into the target site to achieve targeted therapy; for another example, the hydrogel is injected into the damaged organs in the body to form a stable porous structure, allowing living cells to grow on it to repair the damaged organs of human beings. The magnetic hydrogel is developed to improve the targeting and treatment effect of magnetic induction hyperthermia.

[0033] As shown in Fig. 1, in the present application, a self-temperature-controlled magnetic hydrogel manual implantation device is provided, which comprises a needle cylinder 2, the needle cylinder 2 is loaded with magnetic hydrogel; the needle cylinder 2 comprises a needle head interface 4, an injection implantation needle 6 is installed on the needle head interface 4, and a temperature control unit 5 is installed at the position of the needle head interface 4.

[0034] In actual use, the magnetic hydrogel in the needle cylinder 2 is injected into the designated site through the injection implant needle 6, such as in some cases, for the treatment of liver cancer, it is injected into the liver tumor site; for the treatment of rectal cancer, it is injected into the rectal tumor site; for the treatment of colon cancer, it is injected into the colon tumor site; etc.; during this period, in order to avoid the influence of the human body to cause the magnetic hydrogel to solidify in the needle tube, such as the magnetic hydrogel is prone to solidification at a temperature of ≥ 36 ℃, at this time, the temperature of the injection implant needle 6 is controlled by the temperature controller, such as the temperature of the injection implant needle 6 is controlled at room temperature (10.0 ℃-23.0 ℃), at this temperature range, the magnetic hydrogel in the injection implant needle 6 is in a flowing state, since the magnetic hydrogel flowing out of the needle tip of the injection implant needle 6 is in a flowing state, it avoids blocking the needle hole of the injection implant needle 6, and at the same time, after the magnetic hydrogel is injected into the target treatment site, it can quickly solidify into a gel, preventing penetration into the surrounding normal tissue, avoiding the loss of magnetic heat nanoparticles, thereby improving the tumor killing effect and ensuring the targeting of treatment.

[0035] Of course, for the temperature controller in this application, it can be designed in a split type between the needle interface 4, such as the case shown in the figure, the temperature control unit 5 includes a mounting hole with internal threads, which is threadedly connected between the needle interface 4; of course, the detachable way of threaded connection is only one of them, in actual use, it can be designed in other split type according to the needs; the purpose is to facilitate the temperature controller to be installed on the needle interface 4, or to be detached from the needle interface 4; in actual use, in this way, the injection implant needle 6 is first installed on the needle interface 4, and then the temperature controller is installed.

[0036] Of course, for the temperature controller in this application, it can be designed in an integral type with the needle interface 4, such as the temperature controller is integrally formed on the needle interface 4 by the connecting piece 1; such as it can be applied to the needle tube and the injection implant needle 6 in an integral type, the temperature controller is pre-held on the needle interface 4, which is convenient for direct operation.

[0037] In this application, the principle of the temperature controller controlling the injection implant needle 6 is to use heat conduction, such as the temperature controller itself is heated, and the heat conduction of the injection implant needle 6 itself is used to reduce or avoid the solidification of the magnetic hydrogel flowing through the injection implant needle 6; of course, in some cases, the material of the injection implant needle 6 is a medical non-magnetic metal material; the medical non-magnetic metal material includes titanium alloy, nickel-titanium alloy, cobalt-based alloy, etc.; the purpose is to prevent the magnetic nanoparticles in the magnetic hydrogel from being adsorbed in the injection implant needle 6; for the heat conduction mode, under the material of the injection implant needle 6, it can quickly and effectively conduct heat.

[0038] For the temperature controller, such as in the drawings of the present application, the temperature controller is, for example, a micro-TEC (semiconductor refrigerator), or a thermistor, etc.; the hot end of the TEC is located on the outer surface, and the cold end is attached to the implant needle; the TEC is powered to cool the implant needle to ensure that the temperature of the hydrogel is lower than the solidification value; of course, the above-mentioned temperature controller only refers to one, in actual use, a circulating water temperature controller can also be selected; and the like.

[0039] As shown in FIG. 2, of course, in order to reduce the adhesion of magnetic hydrogel in the needle cylinder 2 or in the injection implant needle 6, a hydrophobic layer can be attached to the inner wall of the needle cylinder 2 and / or the channel wall of the injection implant needle 6, such as in the drawings of the present application, a hydrophobic layer 21 is attached to the inner wall of the insulating body 22 of the needle cylinder 2; a hydrophobic layer 62 is attached to the inner wall of the insulating non-magnetic needle body of the injection implant needle 61; the use of the hydrophobic layer reduces the adhesion of the magnetic hydrogel in the needle cylinder 2 or in the injection implant needle 6; when the adhesion of the magnetic hydrogel in the needle cylinder 2 or in the injection implant needle 6 is reduced, that is, during the implantation of the magnetic hydrogel in the needle cylinder 2 through the injection implant needle 6, the speed of the magnetic hydrogel flowing out of the needle cylinder 2 or the injection implant needle 6 is accelerated, thereby reducing the influence of the ambient temperature of the needle cylinder 2 or the injection implant needle 6 on the magnetic hydrogel itself, such as the influence of the human body causing the magnetic hydrogel to solidify in the needle cylinder, and the magnetic hydrogel is prone to solidification;

[0040] For the selection of the hydrophobic layer, in some cases, the hydrophobic layer is selected as a nanometer film, which utilizes the hydrophobic, self-cleaning and antibacterial properties of the nanometer film to reduce the adhesion of the magnetic hydrogel in the needle cylinder 2 or in the injection implant needle 6; of course, in actual use, other materials can also be selected for the hydrophobic layer, such as polytetrafluoroethylene (PTFE), dihydrofluorescein or silicone, etc.

[0041] Of course, in an optional case of the present application, the outer wall of the needle cylinder 2 is attached with a heat preservation layer 23, which is used to avoid the influence of the external environment on the magnetic hydrogel in the needle cylinder 2 to cause the magnetic hydrogel to solidify due to the increase in temperature; in some cases, the heat preservation layer 23 is selected as a heat preservation film, which utilizes the heat preservation performance of the heat preservation film; of course, in actual use, other materials can also be selected for the heat preservation layer 23, such as PTFE, micrometer-level thin ceramic coating, and other medical heat preservation coating materials.

[0042] The above utilizes heat preservation or temperature control and improves the fluidity of the magnetic hydrogel, so that the magnetic hydrogel has a certain fluidity, and in the treatment stage, the amount of the magnetic hydrogel can only be injected quantitatively according to the clinical needs; that is, the accuracy of the amount of the magnetic hydrogel is required, and on the basis of the above, as shown in FIG. 3, the application improves the implantation precision of the magnetic hydrogel in some cases, and also includes: the rotating push rod 1 includes the connecting piece one 11 and the connecting sleeve 12, one end of the connecting piece one 11 is fixedly installed with the piston 13, the piston 13 is attached between the inner wall of the needle cylinder 2, and the connecting sleeve 12 fixedly connected with the piston 13 away from the one end of the connecting piece one 11 is partially sleeved on the outer wall of the needle cylinder 2, the piston 13 of the rotating push rod 1 pushes the magnetic hydrogel in the needle cylinder 2, so that the magnetic hydrogel loaded in the needle cylinder 2 is injected into the target position through the needle; the outer wall of the needle cylinder 2 is installed with the quantitative knob 3 moving along the length direction of the needle cylinder 2, when the piston 13 of the rotating push rod 1 pushes the magnetic hydrogel in the needle cylinder 2, until the connecting sleeve 12 of the rotating push rod 1 abuts against the quantitative knob 3; the outer wall of the needle cylinder 2 is provided with external threads matched with the quantitative knob 3; the outer wall of the needle cylinder 2 is threadedly connected with the connecting sleeve 12.

[0043] When the implantation device is inserted into the human tissue, first rotate the quantitative knob 3 to the predetermined scale line, then rotate the rotating push rod 1, the push rod injection implantation needle 6 needle tip direction movement pushes the self-controlled temperature magnetic hydrogel to flow to the needle tip direction, until the rotating push rod 1 and the quantitative knob 3 contact, which indicates that the predetermined amount of self-controlled temperature hydrogel is implanted; the implantation amount of the self-controlled temperature magnetic hydrogel is accurately controlled.

[0044] In the description of the present specification, the description of the terms "one embodiment", "example", "specific example" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0045] The basic principles, main features and advantages of the present application are shown and described above. It should be understood by those skilled in the art that the present application is not limited by the above embodiments, and the above embodiments and descriptions in the specification are only to illustrate the principles of the present application, and various changes and improvements can be made without departing from the spirit and scope of the present application, and these changes and improvements all fall within the scope of the claimed present application.

Claims

1. A self-temperature-controllable magnetic hydrogel manual implantation device, comprising: a syringe (2) in which a magnetic hydrogel is loaded; the syringe (2) comprises a needle interface (4), and an injection implantation needle (6) is installed on the needle interface (4), characterized in that a temperature control unit (5) is installed in the position of the needle interface (4).

2. The self-regulated magnetic hydrogel manual implantation device according to claim 1, wherein, The temperature control unit (5) is detachably connected with the needle interface (4).

3. The self-regulated magnetic hydrogel manual implantation device according to claim 2, wherein, The temperature control unit (5) comprises a mounting hole with internal threads, which is threadedly connected with the needle interface (4).

4. The self-regulated magnetic hydrogel manual implantation device according to claim 1, wherein, The temperature control unit (5) comprises a semiconductor refrigerator.

5. The self-regulated magnetic hydrogel manual implantation device according to claim 1, wherein, The material of the injection implantation needle (6) is one of titanium alloy, nickel-titanium alloy, and cobalt-based alloy.

6. The self-regulated magnetic hydrogel manual implantation device according to claim 1, wherein, The outer wall of the syringe (2) is attached with a heat preservation layer (23).

7. The self-regulated magnetic hydrogel manual implantation device according to claim 6, wherein, The heat preservation layer (23) is one of polytetrafluoroethylene and micron-level thin ceramic coating.

8. The self-regulated magnetic hydrogel manual implantation device according to claim 1, wherein, The inner wall of the syringe (2) and / or the inner passage wall of the injection implantation needle (6) is attached with a hydrophobic layer.

9. The self-regulated magnetic hydrogel manual implantation device according to claim 8, wherein, The hydrophobic layer is one of nanomembrane, polytetrafluoroethylene, dihydrofluorescein, or silicone resin.

10. The self-regulated magnetic hydrogel manual implantation device according to claim 1, wherein, Further comprising: a rotating push rod (1) comprising a connecting piece I (11) and a connecting sleeve (12), one end of the connecting piece I (11) is fixedly installed with a piston (13) which is attached to the inner wall of the syringe (2), and the end of the connecting piece I (11) away from the piston (13) is fixedly connected with the connecting sleeve (12), part of the connecting sleeve (12) is sleeved on the outer wall of the syringe (2), the piston (13) of the rotating push rod (1) pushes the magnetic hydrogel in the syringe (2), so that the magnetic hydrogel loaded in the syringe (2) is injected into the target position through the needle; an outer wall of the syringe (2) is installed with a dosing knob (3) which moves along the length direction of the syringe (2), during the process that the piston (13) of the rotating push rod (1) pushes the magnetic hydrogel in the syringe (2), until the connecting sleeve (12) of the rotating push rod (1) abuts against the dosing knob (3); an outer thread is formed on the outer wall of the syringe (2) and threadedly cooperates with the dosing knob (3); the outer wall of the syringe (2) is threadedly connected with the connecting sleeve (12).

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