A bioactive fat membrane processing apparatus for human skin injuries

Abstract

This invention relates to a medical device that generates a bioactive membrane using autologous fat and plasma. Belly fat is gently extracted using a syringe and passed through filters of different sizes to remove impurities. This purified fat is then mixed with platelet-rich plasma, which is made from the patient's blood. The mixture is placed in a special temperature-controlled incubator where it's shaken and exposed to red light. This apparatus facilitates the nano fat cells and iPRF to bind together, creating a thin, stretchy membrane. This membrane is then placed on the skin to cover injuries, scars, or create new skin. The fat membrane contains stem cells and growth factors, which promote healing and regeneration. It's a natural and safe way to improve skin health and appearance. This device has the potential to revolutionize plastic surgery and dermatology by offering new solutions for skin issues and enhancing recovery from procedures.

Description

A Bioactive Fat Membrane Processing Apparatus for Human Skin Injuries

[0001] Skin is always one of the most important parts of human beings in both terms of health and appearance, unfortunately, sometimes people can go through a skin crisis and spend a lot of time in dermatology clinics and money, and problems like scars, burning, and diseases such as necrosis, diabetic foot, bed sores, keloid, and infected wounds which leaves very difficult solutions or even no solution for the patients but to lose their hopes. Especially when skin damage happens in the facial area, it damages the beauty and may affect a person’s self-confidence. Nowadays, there are many cures and medicines for the mentioned incidents, but most are made of unnatural chemicals and have many side effects.

[0002] The fat membrane processing device is a new way for people to experience a new soft reparative coverage membrane that induces the skin to repair itself. This device creates a regenerative membrane by mixing the patient’s body fat with their blood plasma to make a new membrane for covering damaged skin and mucosa that induces repair by using the invented tools.

[0003] A61B 17 / 00 - A61P 17 / 02

[0004] 1- CN108355170B

[0005] A kind of concentrated nano fat and its preparation method and application

[0006] The invention discloses a concentrated nano fat and a method for preparing the concentrated nano fat. The steps of this method include (1) centrifugation to remove water, (2) preparation of nano-fat, (3) negative pressure centrifugation, and (4) second centrifugation. The invention also discloses the application of concentrated nano fat to prepare matrix blood vessel components. The invention further discloses the application of concentrated nano fat in the preparation of platelet rich plasma. The invention also discloses a transplanting material of concentrated nano-fat and platelet-rich plasma.

[0007] The mentioned invention at hand involves a physical apparatus; The prior art does not produce a membrane; it prepares an injectable product. There is no use of mechanical activation such as vibration, red light, and cold incubation, and no structural control over the shape or thickness of the final product. It also does not integrate an automated, bedside-compatible device for clinical use.

[0008] 2- US10478587B2

[0009] Device and method for preparing tissue, particularly adipose tissue

[0010] A device and a method for preparing adipose tissue for transplantation from lobular fat extracted, for instance by liposuction, the fat including a fluid component that have an oily component, a blood component and / or sterile solutions, and a solid component including cell fragments, cells and one or more cell macroagglomerates of heterogeneous size, wherein the device includes at least one washing and separating container having a washing chamber, the container has an inlet and an outlet for the liposuctioned material to enter the washing chamber through the inlet and for at least part of the material to exit the washing chamber through the outlet, the washing chamber including stirring means for forming an emulsion of fluid components.

[0011] The mentioned invention describes a closed-loop system for washing and fragmenting adipose tissue for autologous injection in various medical indications. The said patent processes only fat tissue; it does not combine with PRP or PRF. It does not produce a membrane; only injectable fat. The said patent lacks platelet activation mechanisms such as light or vibration. It does not form a structured, implantable bio-membrane for wound coverage or provide a multi-functional unit integrating multiple steps.

[0012] 3- WO2005 / 105121A1

[0013] USE OF PLATELETS OR PLATELET RICH PLASMA

[0014] A new use is disclosed for the content of platelets or platelet rich plasma (PRP) obtained by disruption of their membranes for the preparation of an agent for the treatment of bone, cartilage or skin.

[0015] This patent relates to the activation of platelet-rich plasma (PRP) using ultrasound waves to accelerate growth factor release for therapeutic use. The said patent focuses solely on PRP activation, and there is no use of adipose tissue; no membrane or combination product is formed. It does not involve physical processing components or integrated device design and lacks wound-specific application capability. The mentioned invention is not suited for use as an autonomous system for bedside application.

[0016] 4- US20210100573A1

[0017] Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal

[0018] This invention describes a surgical tool designed for harvesting fractional skin grafts to enhance healing or reduce scarring. In the mentioned invention, there is no biological material processing (blood or fat)m and it is mechanically oriented without regenerative content. It does not produce or process membranes, lacks autologous, bioactive output, and generally it is generally not a biochemical or bioengineering solution.

[0019] 5- CN105246439B

[0020] Wound or skin treatment device with variable edge geometry

[0021] The devices, kits, and methods described herein are provided for treating skin, including but not limited to wound healing, treating, ameliorating, and / or preventing scars and / or keloids. The dressing may be applied to the subject using a book-like package, an applicator, and / or a tensioning device. The packaging, applicator and / or tensioning device applies and / or maintains strain in the elastic dressing and includes a wavy edge configuration to reduce peak stresses applied to the skin as compared to conventional dressing shapes.

[0022] The mentioned patent describes a wound dressing designed with special geometric patterns to reduce mechanical stress on healing tissues. It is a synthetic, prefabricated product, not a biological or regenerative content. It is not derived from autologous materials, and there is no processing device or active ingredient. Overall, It is not suitable as a substitute for bioactive membranes.

[0023] A device that is designed to create a fat membrane using a person's blood and fat for wound coverage and repair. Blood is centrifuged using the PRP method to separate plasma, which is then converted into liquid PRF without adding any special substances. Body fat is extracted using a nano-fat separation kit, which includes a fat extraction cannula and filters for purification. Both the plasma (PRF) and fat (nanofat) enter the device, where they are treated with red light, vibration, and cold chain. The device facilitates the integration of nanofat and injectable PRF (iPRF) to activate blood platelets, which stick to fat cells, forming a solid, jelly-like fat membrane that is elastic and adheres to the wound. The device functions like an incubator with various containers made of silicone and stainless steel, designed for disposable use. The containers have ends for syringe connection and locking, allowing for the simultaneous injection of fat and plasma. Inside, a mesh container controls the membrane's thickness and collects excess liquid. The device includes a metal cold transfer tray to fix the containers and chill them using ice packs. A vibrating plate with a motor creates movement that helps form membranes. Sterile gauze cloth absorbs excess water from the fat membrane and is replaceable. The device uses violet lights for disinfection after the membrane is made, while red light activates for one minute during the process. Two switches control the device's power and disinfection.

[0024] Chronic wounds remain a formidable clinical challenge due to their susceptibility to infections and prolonged healing durations, often rendering conventional therapies inadequate. To address these limitations, this innovation introduces an advanced therapeutic approach leveraging a device designed to create a bioactive fat membrane derived from the patient’s adipose tissue. The process begins with the gentle extraction of abdominal fat using a syringe, followed by filtration through filters with different pore sizes to eliminate impurities. The purified fat is then combined with platelet-rich plasma (PRP), obtained from the patient’s blood, to form a mixture rich in stem cells and growth factors.

[0025] This pioneering device holds the potential to revolutionize wound management and aesthetic procedures by offering a natural, patient-specific, and highly effective solution for skin regeneration and recovery.Solution of Problem

[0026] This apparatus weighs approximately 15 kg, and its dimensions are 41 cm in length, 36 cm in width, and 40 cm in height. It uses the person's blood and fat to create a membrane-like covering layer that can be used to cover wounds like a layer and help the wound heal itself. For this purpose, a certain amount of blood is taken from the person on an outpatient basis and this blood is centrifuged to separate its plasma (blood is made up of two main cellular parts, which include red blood cells, white blood cells, and platelets, and a liquid part called plasma, which contains water, electrolytes, and nutrients such as sugar and fat, as well as immune defense substances such as antibodies).

[0027] Some fat is also obtained from the body through gentle suctioning. The combination of plasma and fat inside this device produces a membrane-like product that has wound-healing properties. This device uses physical properties that affect blood platelets, activating them and stimulating the secretion of wound-regenerating substances.

[0028] This patent, with the help of red light, cold chain, and vibration, can activate platelets in a way that adheres to fat cells and creates a membrane and layer that is from the person's own body and does not have the possibility of transmitting infection or allergic reactions and rejection and has healing properties and can help treat difficult-to-heal wounds such as diabetic wounds and bedsores or pressure ulcers or infected wounds and burn wounds and necrosis. Everybody has a self-healing property, for example, if our hand is cut with a razor, at first blood will flow and a wound will be formed, but after a few days, the body's regeneration mechanisms will repair the wound site and the wound will be healed after a few days. The regenerative effects and help in the regeneration of substances extracted from a person's blood, such as PRP, have been known for a long time, and in restorative and visual medicine, the use of PRP, which is the same as the extract of activated plasma platelets, is used routinely and daily. PRP is obtained by centrifuging blood after two rounds and with specific times, but to make this membrane, the blood is used only once and with a specific round. the centrifuging is processed for a specific time and separate the blood plasma. This plasma contains platelets floating in the blood and can clot because platelets are the main cells in the body that cause clots. If a person has low platelets or does not have good and proper activity, their blood will not clot or their coagulation mechanism will be impaired. The obtained liquid is called PRF, and its difference from PRP is the amount of floating platelets in it. In addition, to obtain PRP, blood plasma must be activated with special substances to release the substances inside it, but to obtain this PRF plasma, there is no need to add liquid and activating drugs. PRF is obtained in two forms, solid and liquid, depending on the centrifuge speed, and its liquid form is used to make a fat membrane. Extracting fat from the body and returning it to other parts of the body after physical processing and without adding special substances is a well-known process in medicine, and fat injection is used in skin volume rejuvenation and wound healing.

[0029] The fat that is removed from the body, if prepared under certain conditions, contains living cells that, when these living cells are transferred to another location in the same person's body, implant in the new location and continue their life and activity.

[0030] If this fat is removed from the body, and passes through special filters and sieves with specific diameters, its waste materials are removed, and valuable components such as stem cells located in the adipose tissue and vascular parts, fibroblast cells, and collagen-forming cells remain along with the fat cells.

[0031] Body fat tissue is extant throughout the body, especially under the skin, and along with the bone marrow and liver, it is one of the most important areas where germinal or primary cells, or stem cells, are abundant so that between 0.1 and 1 percent of adipose tissue is made up of these stem cells. In addition, adipose tissue, especially if it is in the form of nanofat, contains a large amount of cell growth factors.

[0032] The term nano fat has been popular in medicine since 2013, and it refers to the extraction of fat with thin needles and tubes with holes of one millimeter in diameter. Then, this fat is transferred between two syringes until it becomes almost white and foamy, just like egg yolks that are used to make a cake. Then, this liquid fat is passed through filters, and the result is called nanofat. It has been found that the inside of this nanofat is full of growth factors, especially vascular growth factor and growth factor of collagen-forming cells and stem cells.

[0033] By combining centrifuged blood plasma (PRF), which is a liquid, and the person's body fat (nanofat), which is also a type of liquid, inside this device, a product is attained that activates platelets with the physical properties of cold, red light, and liquid vibration, and activates the coagulation cascade mechanism. It is a solid jelly-like membrane that is elastic and sutureable, contains germ cells and live cells, and can be used to cover wounds, and is expected that the wound will heal significantly.

[0034] - Components of the fat membrane processing device with the explanation of each part:

[0035] This device is a container with a lid that has parts placed inside it, and functions as a type of incubator.

[0036] -Valved reservoir containers with lids:

[0037] A valved reservoir container with a lid is a two-layer container that has a valve at the bottom for draining and collecting the liquid. These containers are designed in the shape of rectangular, square, and cylindrical cubes. Each of these containers has the same properties and uses the same thing, and only the result they produce has a different shape. These containers are made of stainless steel or disposable medical silicone (if the purpose is to use disposable items, the container is made of silicone, and if it is used several times, it is made of steel). On the lid of this device, which is separated from the container, there are two ends for connecting the syringe and locking the syringe by screwing it to these inlets. This type of screw head is called a "luer lock". These inlet heads are essential for the simultaneous injection of fat and plasma.

[0038] Inside this container, there is another container whose walls are mesh. This mesh is shaped like a container, but its mesh fragment is five millimeters away from the bottom of the container, and the mesh part starts at a higher distance than the bottom of the container. This mesh can be removed from the container. The purpose of the mesh hole spacing from the bottom, is to control the thickness of the fat membrane or the product itself.

[0039] The reason why the holes start from above the wall is because the excess fat and plasma spill out of it and collect in the container tank.

[0040] The container tank has a lattice shape and has grooves in it that collect excess liquid and ends with a sloping tunnel that ends with a luer lock valve through which excess liquid can be removed.

[0041] -Metal cold transfer tray:

[0042] This tray is a metal plate that has rectangular, circular, and square cube containers on it so that when these containers are placed on it, they are fixed and do not easily move on the moving plate so the liquid inside the container spills out. The task of this tray is to transfer the cold of the lower ice bag to the containers holding the liquid.

[0043] -Vibrating plate:

[0044] This plate is responsible for transmitting vibration from the device to the cold transfer plate.

[0045] The vibrating plate is equipped with a motor that causes the containers to move up and down. This movement helps to form membranes. This plate is activated by two electrical methods with a small vibrating motor or by a mechanical method of pressing the internal shock absorbers and using regulation.

[0046] The motor of the device is placed inside and has an activation switch so that when the vibrating tray is inserted, the motor is activated. The motor of the device is designed with a limited sliding time and is connected to a timer that sets the appropriate time.

[0047] -Cold tank:

[0048] This tank is attached to the vibrating plate and is located under it, and ice packs or ice packs are placed inside it. Cold activates platelets hardens the fat membrane and plays a key role in its formation.

[0049] -Red cold light source:

[0050] Red LED lamps with a length of 470 to 420 nanometers are assembled into the ceiling of this device. This wavelength of light activates platelets.

[0051] When two liquids are poured into these containers and mixed with the help of movement, Nanotechnology, cold chain, and red light shining into the tank, an effective and stable combination of fat and plasma called fat membrane is achieved within ten minutes.

[0052] -Pressure seals:

[0053] There are plates exactly the size of rectangular, square, and cylindrical containers that have points around them from the outside and a central screw location to which the handle of this seal is screwed in the center. This stamp-like seal device is designed to compress the fat membrane and the sterile gauze fabric is attached to its points and the lower part of the seal is upholstered and covered with sterile gauze fabric. The function of this seal is to remove excess water from the fat membrane inside the tank container, and after compressing the fat membrane, the gauze is separated from its points and can be replaced with new gauze.

[0054] -Violet lights:

[0055] On the ceiling of the device, violet lamps are installed inward, whose function is to emit violet light with a wavelength of about seven hundred nanometers. After using the device and making the fat membrane, these lamps can be used to disinfect the internal environment of the device. They can go on for a few hours to disinfect the environment inside the device.

[0056] -Centrifuge section:

[0057] This unit, which is detached from the main tank, is responsible for centrifuging and separating blood plasma.

[0058] -Nanofat separation set:

[0059] This section, which is detached from the main device, includes fat extraction cannulas, cannulas for injecting tumescent or anesthetic liquid, seven hundred, five hundred and three hundred micrometer filters, and two-head syringe-to-syringe connectors in diameters of three and two tenths, two and seven-tenths, two and two tenths, one and seven-tenths, and one and two tenths.

[0060] The sets of nanofat and the centrifuge device are only connected to the main device and the tank and are separate from the membrane manufacturing device.

[0061] -The red light turns on when the device door is closed for 1 minute, simultaneously with the rocking motion system.

[0062] After 1 minute, the device is fixed in the middle position, and when the device door is opened, the red light turns off.

[0063] -There is a separate switch for the blue light behind the device so that the user can turn it on separately after completing tasks.

[0064] -There is also a switch to turn the device on, and the second key is for disinfecting the device.Advantage Effects of the Invention

[0065] 1) Using only two liquid phases of plasma and nano fat without any extra peculiar substances.

[0066] 2) The process is based on the natural body fat adipose-derived stem cells that are pluripotent mesenchymal cells and can change themselves to other cells, and also platelet-derived growth factors and nano fat growth factors that accentuate each other.

[0067] 3) The fat tissue is one of the richest reservoirs of stem cells in the human body

[0068] 4) The fat membrane can cover all the skin injuries and wounds to create a new skin layer.

[0069] 5) The fat membrane is full of live Adipose-derived stem cells.

[0070] 6) The resulting fat membrane also has Platelets, which are filled with growth factors.

[0071] 7) It promotes the revascularization and regeneration of the tissue.

[0072] shows the aluminum plate circular stamp.

[0073] shows the square aluminum plate stamp.

[0074] is the stainless steel round container.

[0075] displays the stainless steel round container from a side view.

[0076] presents the aluminum round container from four angles.

[0077] shows the aluminum round lid.

[0078] is the stainless steel square container.

[0079] is showing the aluminum square container.

[0080] displays the aluminum square lid.

[0081] shows the large aluminum plate for cold transfer.

[0082] shows the aluminum plate template.

[0083] presents the cannulas and syringes.

[0084] displays the syringe stand.

[0085] shows the nano fat transfer cartridge-Mesh.

[0086] presents the luer lock.

[0087] represents the luer lock to luer lock nano fat transfer filtration.

[0088] shows the luer lock to luer lock nano fat transfer filtration and screening.

[0089] shows the exploded view drawing of the claimed device.Description of Embodiment

[0090] shows the aluminum plate circular stamp and its details:

[0091] 1- The compressing part

[0092] 2- Compression handpiece

[0093] 3- Sterile gauze pad holder

[0094] shows the square aluminum plate stamp with its details:

[0095] 4- the compressing part

[0096] 5- Compression handpiece

[0097] 6- Sterile gauze pad holder

[0098] is the stainless steel round container from an upper angle:

[0099] 7- the stainless round container from the nano fat and RPF collection.

[0100] displays the stainless steel round container from a side view:

[0101] 8- the stainless round mesh.

[0102] presents the aluminum round container from four angles:

[0103] 9- An aluminum round container’s part for shaking the fat membrane.

[0104] 10- Aluminum round container holes for drainage.

[0105] 11- Aluminum round container holder clip for stability.

[0106] shows the aluminum round lid and its different angles:

[0107] 12- Two luer lock entrances

[0108] 13- the aluminum round lid

[0109] 14- Holder

[0110] is the stainless steel square container:

[0111] 15- Stainless steel square container from nanofat and PRF collection.

[0112] 16- Stainless steel square mesh from nanofat and PRF collection.

[0113] is showing the aluminum square container and its details:

[0114] 17- Aluminum square container for shaking the fat membrane.

[0115] 18- Aluminum square container holes for drainage.

[0116] 19- Aluminum square container holder clip for stability.

[0117] 20- Aluminum square container lock for stability.

[0118] displays the aluminum square lid from various angles:

[0119] 21- Aluminum square lid.

[0120] 22- Two luer lock entrances of the aluminum square lid.

[0121] shows the large aluminum plate for cold transfer from different perspectives:

[0122] 23- Placement of the round container.

[0123] 24- Placement of the square container.

[0124] 25- Large Aluminum plate holder.

[0125] 26- Large Aluminum plate for cold transfer.

[0126] shows the aluminum plate template.

[0127] 27- The aluminum plate template for fixing a large aluminum plate.

[0128] presents the canulas and syringe:

[0129] 28- Stainless steel cannula pipe with 7 holes.

[0130] 29- Fixed hub with cannula.

[0131] 30- Luer lock syringe connector fixed hub.

[0132] displays the syringe stand:

[0133] 31- The syringe stand for holding 5 syringes and it's stainless steel.

[0134] 32- The luer lock syringe stand connector.

[0135] shows the nano fat transfer cartridge-Mesh from 3 angles:

[0136] 33- Nanofat transfer cartridge’s ring.

[0137] 34- Nanofat transfer cartridge’s mesh.

[0138] presents the luer lock:

[0139] 35- Luer lock to luer lock connector’s body.

[0140] 36- Luer lock to luer lock connector’s hole.

[0141] 37- Luer lock to luer lock connector’s syringe connector.

[0142] represents the luer lock to luer lock nano fat transfer filtration:

[0143] 38- Luer lock at transfer filtration and screening (Placement of the NanoFat transfer cartridge-Mesh)

[0144] 39- Luer lock at transfer filtration and screening (Syringe connector)

[0145] shows the luer lock for transfer filtration and screening:

[0146] 40- Syringe connector

[0147] 41- Screw thread

[0148] shows the exploded view drawing of the claimed device and all the components:

[0149] 42- Centrifuge top lid (Glass)

[0150] 43- Inner chamber of the centrifuge

[0151] 44- Centrifuge circular plate and motor

[0152] 45- Metal plate and Centrifuge vibration modifier

[0153] 46- Centrifuge electronic board

[0154] 47- LED with red and ultraviolet light

[0155] 48- Main shell of the device

[0156] 49- Bottom plate of the device

[0157] 50- Drawer of accessories

[0158] 51- Shaking system drawer

[0159] 52- Rail

[0160] 53- Rail wagon

[0161] 54- Servo motor of shaking system

[0162] 55- Placement plate for the ice pack and aluminum parts

[0163] 56- Placement template of ice packExamples

[0164] This device helps create customized skin-like grafts for patients with skin injuries. The embedded technology is particularly effective for individuals with injuries, scars, burns, skin loss, slough or necrosis, keloids, and infected wounds.

[0165] The process begins with the extraction of adipose tissue (fat) from the patient, which is then combined with their blood plasma to form a unique biological mixture. This personalized approach not only promotes better integration with the patient's existing tissue but also enhances healing.

[0166] For instance, consider a patient who has sustained a burn that has left a prominent scar on the nose. In such a case, medical professionals can craft a circular fat membrane that precisely matches the dimensions of the scar. Using a specially designed template, they will mix the harvested fat and blood in the processing unit to generate the graft. Once the membrane is prepared, it is carefully stitched onto the affected area.

[0167] Following the application of the membrane, the medical team must provide diligent post-operative care. This includes moisturizing the graft site regularly for two weeks, ensuring optimal healing conditions, and minimizing the risk of complications.

[0168] The careful attention to both the creation and aftercare of the graft contributes significantly to the success of the treatment, promoting effective recovery for the patient.

[0169] The square-shaped membrane is suitable for the forehead and the circle-shaped one is decent for the nose; they will be placed on the demanded skin part and the doctor will stitch it to the skin. After the suturing process, Vaseline gauze will be put on it.

[0170] The doctor has to moisturize the surgery parts for 10 days to 2 weeks with normal saline 0.9% spray and mupirocin ointment. This operation is an office-based one and it can be done for all the cases.

[0171] This invention is poised to become a fundamental device in the plastic surgery industry, significantly enhancing procedures aimed at improving beauty standards. It will enable surgeons to achieve more precise and natural-looking outcomes, thereby meeting the diverse aesthetic desires of patients more effectively. Additionally, this invention has the potential to revolutionize the broader medical field by offering new solutions for skin and mucus health. By addressing a variety of dermatological issues, it can provide patients with renewed confidence and vitality, leading to improved overall well-being. The application of this technology could pave the way for advanced treatment options that promote healthier skin and enhance the recovery process for individuals undergoing cosmetic and medical procedures.

Claims

A device for producing a fat membrane using the individual’s blood and fat to cover and repair their wounds.The device of claim 1, wherein to create a covering membrane with it, blood taken from a person is centrifuged using the PRP method, but in one step and without adding any substances, its plasma is separated and converted into liquid PRF.The device of claim 2, wherein the required body fat is extracted by a nano-fat suctioning set that includes a fat extraction cannula and purified through filters.The device of claim 3, wherein the plasma (PRF) and fat (nanofat) liquids enter the device (intended containers) and are affected by the embedded red light, and vibration inside.The device of claim 4, wherein with the help of a cold spreading chain, red light, and vibration, blood platelets are activated and adhere to fat cells, which causes the formation of a solid, jelly-like fat membrane with elasticity and adhesion to cover the wound.The device of claim 5, wherein there are valved and lidded reservoir containers in square, rectangular, and cylindrical shapes made of silicone (disposable) and stainless steel.The device of claim 5, wherein there are two ends on the lids of the containers for connecting the syringe and locking the syringe with a screw (luer lock) in this apparatus for simultaneous injection of fat and plasma.The device of claim 6, wherein inside the containers of the device, there is another container with mesh walls that are 5 mm away from the bottom of the container, which makes them removable from the container, and is installed to control the thickness of the fat membrane.The device of claim 7, wherein the mesh container has grooves that collect excess liquid and remove excess liquid through an inclined channel that is towards the luer lock.The device of claim 5, wherein a metal cold transfer tray is located on which the containers holding fat and plasma are fixed, and the cold of the ice pack located under the tray is transferred to them.The device of claim 5, wherein there is a vibrating plate in the device encompassing a motor that, by activating the switch, in two electrical ways with a small motor with a timer or by the mechanical method of compressing the internal shock and tuning, causes the containers to move up and down and form membranes.The device of claim 5, wherein the cold tank is located under the vibrating plate, which contains ice packs and plays an important role in hardening the membrane.The device of claim 5, wherein there are plates as large as all the containers inside the device that have a central secure location on the outer surfaces outside, and the handle of the pressure seals is screwed to the center to form a stamp-like seal for compressing the fat membrane.The device of claim 12, wherein a sterile gauze cloth is attached to the outer points of the pressure seal of the device set, and the lower part of the sterile gauze cloth is covered to absorb excess water from the fat membrane; they are also removable and replaceable.The device of claim 5, where violet light lamps are installed on the roof to shed violet light at a wavelength of about 700 nanometers inside the device and disinfect the device after the membrane manufacturing process.The device of claim 5, wherein the red light turns on when its door is closed and operates for 1 minute simultaneously with the shaking system of the device, and then turns off when the door is opened.The device of claim 5, wherein the ultraviolet and violet lights are available, plus a blue light with a switch behind the device that can be turned on separately after the process.The device of claim 5, wherein two switches are installed to turn it off and disinfect it.

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