Phytotherapeutic compound for topical use on burns and method for obtaining it

Abstract

This patent relates to a novel phytotherapeutic compound for topical use, specially formulated for the treatment of burns. The innovation lies in the use of a formulation that combines passion fruit leaves (Passiflora sp.) and refined pork fat, providing a natural and effective approach to the management of skin burns. Passion fruit leaves are processed by infusion to extract flavonoids, known for their anti-inflammatory and antioxidant properties, which reduce inflammation and oxidative stress in damaged tissue, facilitating healing. Refined pork fat, chosen for its rich composition of essential fatty acids and its emollient properties, serves as the base for the ointment, helping to absorb the active ingredients and to form a protective barrier that minimises transepidermal water loss and protects against infections. The method of obtaining the compound involves frying the fat to extract lipids, followed by filtration for purification. Subsequently, passion fruit leaf extracts are combined with the purified fat and the mixture is evaporated until it reaches the appropriate consistency for an ointment. This composition not only accelerates the healing of burns, but also significantly alleviates the pain and discomfort associated with such injuries. The compound offers an effective and safe alternative to conventional burn treatments, standing out due to its simplicity, efficacy, and use of natural ingredients, making it particularly valuable in regions with limited access to medical resources.

Description

Herbal compound for topical use in burns and its method of production.

[0001] The present invention relates to a novel phytotherapeutic compound for topical use, specifically designed for the treatment of burns. This compound utilizes a formulation based on natural ingredients, notably combining passion fruit leaves and lard in balanced proportions. Each component is carefully selected to maximize its healing and soothing properties. The lard is fried until the lipids are completely extracted, followed by filtration for purification. Simultaneously, the passion fruit leaves undergo an infusion process to extract the essential active principles which, when combined with the purified fat, form the basis of this compound.

[0002] The method for obtaining this ointment is meticulously developed to preserve the regenerative and soothing properties of the ingredients, resulting in a product with a consistency suitable for topical application. The process includes a controlled evaporation phase, which adjusts the texture of the compound until it reaches the form of a homogeneous ointment. This compound not only facilitates the rapid recovery of affected areas but also significantly reduces the discomfort caused by burns, offering an effective and safe alternative to conventional treatments. Description of the prior art:

[0003] Burn treatment has a long and diverse history, reflecting humanity's ongoing search for more effective and safe methods for skin recovery. Since ancient times, humans have explored a variety of substances and techniques to treat burns. often guided by the availability of local resources and traditional knowledge.

[0004] In ancient times, Egyptians already used honey and resins to treat burns, taking advantage of their antibacterial and healing properties. During the Greco-Roman period, substances such as olive oil and plant extracts were commonly applied. With the advancement of medicine, during the Middle Ages and the Renaissance, substances such as egg white and vinegar began to be recommended, aiming for a more sophisticated and systematic approach to burn treatment.

[0005] In the 19th century, with the rise of modern medicine, treatments began to incorporate a more scientific approach, including the use of antiseptics and the practice of aseptic techniques to reduce infections. The discovery of antibiotics in the 20th century represented a significant advance, allowing for more effective treatments against secondary infections in severe burns.

[0006] Recently, burn treatment has evolved to include advanced technologies and specialized products. Modern dressings, such as hydrocolloids, hydrogels, alginates, and silver-based dressings, create a moist environment that controls bacterial load and promotes healing. Negative pressure therapy has also gained prominence, helping to reduce edema and improve tissue perfusion in deep burns.

[0007] Tissue engineering has brought innovations such as artificial skin and the cultivation of cells from the patient's own skin, which can cover large areas of burns, accelerating healing and reducing the need for grafts. Furthermore, techniques such as laser therapy help improve healing and reduce scar formation, while physiotherapy and other therapies can also be beneficial. Occupational therapies are crucial for regaining functionality in affected limbs.

[0008] Advanced topical products containing ceramides, antioxidants, peptides, and growth factors represent the ongoing development of creams and ointments aimed at improving skin repair and minimizing scarring. These advancements not only treat physical damage but also consider the psychological well-being and quality of life of patients, guiding medical practice toward a more personalized and efficient approach to burn treatment.

[0009] There are other noteworthy solutions that have been gaining prominence, such as the use of tilapia skin in the treatment of burns, a remarkable innovation in regenerative medicine originating in Brazil and gaining worldwide recognition due to its effectiveness and low cost. This method represents a significant advance in the management of burns, especially in resource-limited regions.

[0010] However, despite significant advances in medicine and burn treatment, including the innovative use of tilapia skin and other advanced technologies, significant gaps remain in terms of accessibility, efficiency, and practicality, especially in resource-limited regions. In this context, the proposal of a topical phytotherapeutic compound based on natural ingredients such as passion fruit leaves and lard stands out as a particularly valuable solution.

[0011] This herbal compound offers a number of advantages that meet the urgent needs for burn treatment in an accessible and effective way. Firstly, the ingredients used are widely available and inexpensive, making the treatment highly accessible even for minors. for low-income communities. Furthermore, the preparation process is relatively simple, requiring no sophisticated equipment or specialized facilities, which facilitates implementation in a variety of contexts, from rural areas to urban centers in developing countries.

[0012] The compound's effectiveness is not merely theoretical; it is supported by the known properties of its components. Lard is a lipid-rich base that helps create a protective barrier over burned skin, reducing water loss and protecting against infection. Passion fruit leaves, in turn, are known for their anti-inflammatory and analgesic properties, which relieve pain and accelerate the healing process. When combined, these natural substances form an ointment that not only effectively treats burns but also promotes faster recovery, drastically alleviating pain and suffering for patients.

[0013] Furthermore, no patents or products based on the components and method required herein were observed in the state of the art. Only various compositions using other parts of plants of the genus Passiflora, other than the leaves, were found, and these are not yet associated with a source of animal fat. Therefore, the present solution has never been exposed or revealed to society to date. This premise is supported by the following search of the state of the art, which describes the inventions that most closely match it:

[0014] BR 10 2019 025399 1 refers to an organic biosorbent exfoliant obtained from the modification of passion fruit peel with lactic acid, in a biosorption process, in which, after the asepsis of the passion fruit peels, they are dried and crushed and then treated with lactic acid. For this purpose, both components are mixed and then filtered, with the solid part of the mixture being dried and crushed. The product obtained has properties Chemical and physical properties contribute to its adsorption and absorption, allowing it to be used as an exfoliant.

[0015] CN102872218A describes a Chinese herbal preparation for the treatment of acute radiation skin injuries. Acute radiation skin injury belongs to the burn category in traditional Chinese medicine. Pain is one of the main symptoms of radiation skin injury and is primarily caused by blockage of blood flow in the burned area.Therefore, traditional Chinese medicine, including banana captain, passiflora cochinchinensis, jasminum laurifolium, sticktight, henry clematis root, radix paeoniae rubra, red flower, ash bark, leonurus, and patrinia, with the effects of clearing heat and toxic materials and relieving swelling and pain, are prepared in external liniment. Through clinical trials in hospitals, the overall effectiveness rate reaches 94.9 percent. Furthermore, the stopping time of moist infiltration and the regression time of edema are noticeably shortened, the pain index is clearly improved before and after treatment, and the Chinese herbal preparation is worthy of clinical popularization and application.

[0016] EA032439B1 provides synergistic compositions and methods for preventing and treating dermal wounds and topical ulcers quickly, effectively, and economically. It comprises a synergistic combination of natural products, specifically the combination of an extract of Hydrastis canadensis, an extract of a species of the genus Panax, and an extract of Aloe barbadensis L., which are essentially free of Passiflora incarnata L. extract. The combination can be administered to the wounded skin and / or into a topical wound cavity of a patient as a prophylactic or therapeutic dose, and can optionally be administered via a wet dressing. The present invention further provides kits that can be used for topical application of the combination.

[0017] Upon analyzing application BR 10 2019 025399, it is evident that the use of the aforementioned product is specifically as a skin exfoliant, focusing on sensitive skin. On the other hand, the product proposed in this report uses passion fruit leaves, not the peels, combined with lard in a process that extracts the lipids and active ingredients from the leaves, forming an ointment specifically intended for the treatment of burns. The focus is on pain relief, skin regeneration, and inflammation reduction, differing completely in application and composition.

[0018] CN102872218A details a preparation of various Chinese herbs for the treatment of acute skin lesions caused by radiation, using a liniment that combines multiple plants with effects of clearing heat and relieving swelling and pain. While sharing the goal of treating skin lesions, the product proposed here differs significantly in the simplicity and specificity of its components, using only passionflower leaves and lard.

[0019] EA032439B1 presents a synergistic combination of natural extracts for the prevention and treatment of dermal wounds and topical ulcers. While this method also focuses on topical treatments using natural compounds, our product distinguishes itself by its base of passion fruit leaves and lard, focusing on delivering a more specific application for burns, with a unique approach in terms of extraction and ingredient combination. Brief description of the objectives

[0020] From the above, it is evident that the product and method proposed here offer an original and highly specific approach to the treatment of burns, using natural ingredients with a preparation process that maximizes therapeutic efficacy, especially through the use of... Passion fruit leaves. This new formulation not only fills an important gap in terms of accessible and effective treatments for burns, but also stands out for its innovative method of extraction and combination of active ingredients. It is in this context that the synthesis of the invention's objectives is conceived, the details and functionalities of which can be better understood by the following detailed description. Detailed description of the invention:

[0021] This phytotherapeutic compound for topical use in burns, and its method of production, was specially engineered for the treatment of burns, combining passionflower leaves (Passiflora sp.) with a porcine lipid base (lard) in an innovative formulation. This compound is produced through a meticulous process that maximizes the therapeutic properties of the natural components, resulting in an ointment effective in both healing and relieving pain and inflammation.

[0022] The product is formulated with varying proportions of its main components, ranging from 40 to 60%, to ensure maximum efficacy. This flexibility in proportion allows the formulation to be adjusted to optimize the absorption of active ingredients and the formation of the skin barrier, making the treatment adaptable to different severities of skin lesions and skin types of patients.

[0023] Passion fruit leaves are selected for their high concentrations of flavonoids, such as vitexin and isovitexin, which are known for their anti-inflammatory and antioxidant properties. These components help reduce local inflammation and oxidative stress in damaged tissues, facilitating the healing process. The infusion technique used to prepare the leaves ensures efficient extraction of these active ingredients, guaranteeing their effectiveness in the final formulation.

[0024] In contrast, other parts of the plant, such as the flowers or fruits of the passion fruit, while also possessing certain medicinal benefits, contain a different concentration of bioactive compounds that may not be as effective or specific for the topical treatment of burns. For example, the fruit is best known for its nutritive and mild sedative properties, while the flower is often used for sleep disorders and anxiety, not offering the same direct benefits to the skin as the leaves.

[0025] In addition to its medicinal benefits, choosing passion fruit leaves is also practical. They are relatively easy to grow and harvest in various regions, making them a sustainable and economical option for large-scale production. This aspect is particularly important to ensure that the treatment is accessible and available in communities with limited resources.

[0026] Pork fat, in turn, is chosen for its rich composition of fatty acids, mainly oleic and palmitoleic acids. These fatty acids are natural emollients and possess significant moisturizing properties. In the compound's production process, the lard is carefully fried to extract the essential lipids, and then filtered to purify the resulting fat. This fat not only serves as an effective vehicle for the active ingredients of passion fruit leaves, but also creates a protective barrier over burned skin. This barrier reduces transepidermal water loss and protects against bacterial contamination, crucial elements in the treatment of burns.

[0027] The method of obtaining the product involves combining passion fruit leaf extracts with purified pork fat. After mixing, the mixture undergoes controlled evaporation until it reaches the consistency of an ointment. This careful manufacturing process not only It preserves the bioactive properties of the ingredients, but also ensures that the final ointment is homogeneous and easy to apply.

[0028] The benefits of the compound include accelerated healing due to the synergy between the flavonoids in passion fruit leaves and the fatty acids in lard, which together promote rapid regeneration of skin tissue. Furthermore, the compound offers immediate pain relief and reduces inflammation, providing significant comfort to burn patients. This combination of effects makes the compound a remarkable therapeutic solution in the field of burn treatment, standing out for its simplicity, effectiveness, and use of natural ingredients.

[0029] Finally, it is also worth highlighting the possibility of modifications and adaptations to the raw materials and methodology chosen. The descriptive account in this document should not be considered limiting, but rather illustrative, emphasizing that the basic compound can be enriched with the addition of other natural components that complement or amplify its healing and regenerative properties.

[0030] A notable example of such an additive is melaleuca oil, also known as tea tree oil, an agent known for its powerful antibacterial and anti-inflammatory properties. The inclusion of melaleuca in the formulation can provide an additional layer of protection against infection, a critical aspect in the treatment of burns. Furthermore, melaleuca oil can help accelerate the healing process, further reducing recovery time and improving clinical outcomes.

[0031] Thus, for those skilled in the art, variations may exist that include these or other equivalent ingredients, without, however, departing from the scope of protection of the invention. Such adaptations should be seen as potential improvements that align the compound's formulation with... specific patient needs or new scientific discoveries in the field of dermatology and burn treatment.

Claims

CLAIMS 1. A phytotherapeutic compound for topical use in burns, characterized by containing passion fruit leaves (Passiflora sp) and a porcine lipid base, preferably lard, in the following proportions: • Passiflora sp leaves (40% to 60% of the total dry weight); • Porcine lipid base (40% to 60% of total dry weight).

2. METHOD FOR OBTAINING THE HERBAL COMPOUND FOR BURNS, characterized by encompassing the following steps: • Fry lard until all lipids are extracted; • Filter the lard to remove impurities; • Prepare an infusion of passion fruit leaves to extract flavonoids; • Combine the filtered pork lard with the passion fruit leaf extract; • Evaporate the mixture until it reaches a paste-like consistency.