Methyl nicotine salt and preparation method therefor, atomization liquid, atomizer, and electronic atomization device

Abstract

A methyl nicotine salt, which comprises, in percentages by weight: 20% of methyl nicotine; 4-6% of benzoic acid; 13-15% of lactic acid; and the balance of glycerol. Further provided are a preparation method for the methyl nicotine salt, an atomization liquid containing the methyl nicotine salt, an atomizer using the atomized liquid, and an electronic atomization device comprising the atomizer. The methyl nicotine salt is used for at least partially replacing the nicotine salt in an atomization liquid, and once methyl nicotine is combined with a nicotine receptor in the human body, the sensation of impact thereof on the oral cavity of a user is stronger than nicotine, such that the user can still obtain a relatively strong throat hit when taking in less methyl nicotine, thereby reducing the addictive dependence of the user on an electronic atomization device; in addition, converting methyl nicotine into a methyl nicotine salt is more beneficial for adjusting the taste of the atomization liquid.

Description

Methyl nicotine salts and their preparation methods, atomizing fluids, atomizers and electronic atomization devices

[0001] This application claims priority to Chinese Patent Application No. 202410969366.3, filed on July 18, 2024, entitled "Methyl Nicotine Salt and its Preparation Method, Atomizing Liquid, Atomizer and Electronic Atomizing Device", the entire contents of which are incorporated herein by reference. Technical Field

[0002] This application belongs to the field of atomization technology, and particularly relates to a methyl nicotine salt and its preparation method, atomizing liquid, atomizer and electronic atomization device. Background Technology

[0003] Nicotine is a naturally occurring alkaloid found in tobacco. It is extracted from tobacco and used to prepare the atomizing liquid in electronic atomizing devices. The atomizing components in these devices atomize the nicotine-containing liquid to generate an inhalable aerosol, satisfying the user's physiological needs and thus achieving the effect of relieving addiction.

[0004] In related technologies, nicotine is typically used in electronic vaping devices in the form of nicotine salts. The amount of nicotine salts in the vaping liquid affects the addictive properties of the aerosol produced. Vaporizers with lower nicotine salt content have a weaker throat hit, leading users to inhale more liquid to enhance the throat hit and potentially causing nicotine addiction. Vaporizers with higher nicotine salt content produce a strong odor and irritation, severely impacting the user's vaping experience. Furthermore, vaporizers with high concentrations of nicotine salts can cause significant harm to users.

[0005] Therefore, there is an urgent need to develop a substance that can at least partially replace nicotine salts in atomizing liquids. Summary of the Invention

[0006] In a first aspect, embodiments of this application provide a methyl nicotine salt for use in an atomizing liquid, wherein the methyl nicotine salt comprises, by weight percentage:

[0007] Methyl nicotine 10%~20%;

[0008] Benzoic acid 4%~6%;

[0009] Lactic acid 13%~15%;

[0010] Glycerin balance.

[0011] Secondly, embodiments of this application also provide a method for preparing methyl nicotine salt, the method comprising:

[0012] Benzoic acid, lactic acid, methylnicotine, and glycerol are placed in a reactor and stirred at a speed of 200 r / min to 500 r / min. The reaction temperature is 40℃ to 65℃, and the reaction time is 3h to 5h. After cooling to room temperature, the methylnicotine salt is obtained.

[0013] Thirdly, embodiments of this application also provide an atomizing liquid containing methyl nicotine salt, wherein the atomizing liquid comprises, by weight percentage:

[0014] Methyl nicotine salt 2%~4%;

[0015] Glycerin 35%~40%;

[0016] Fragrance and flavor base liquid 35%~40%;

[0017] The balance of propylene glycol.

[0018] Fourthly, embodiments of this application also provide an atomizing liquid containing methyl nicotine salt, wherein the atomizing liquid comprises, by weight percentage:

[0019] Methyl nicotine salt 0.5%~1%;

[0020] Nicotine salts 8.5%~15%;

[0021] Glycerin 13%~15%;

[0022] Fragrance and flavor base liquid 35%~40%;

[0023] The balance of propylene glycol.

[0024] Fifthly, embodiments of this application also provide an atomizer, the atomizer including a liquid storage chamber and an atomizing component, the liquid storage chamber being used to contain the aforementioned atomizing liquid, and the atomizing component being used to atomize the atomizing liquid to generate an aerosol.

[0025] Sixthly, embodiments of this application also provide an electronic atomizing device, including the aforementioned atomizer and a power supply component that provides electrical drive for the atomizer.

[0026] The methyl nicotine salt, its preparation method, atomizing liquid, atomizer, and electronic atomizing device provided in this application have the following beneficial effects:

[0027] (1) The methyl nicotine salt provided in the embodiments of this application is used to at least partially replace the methyl nicotine salt in the nebulizer. Since methyl nicotine binds to the nicotine receptors in the human body, the oral impact on the user is stronger than that of nicotine. Therefore, the user can still obtain a strong throat hit even with less methyl nicotine inhalation, thereby reducing the amount of methyl nicotine inhaled by the user and thus reducing the user's addictive dependence on the electronic nebulizer.

[0028] (2) Methylnicotine salt is prepared by reacting methylnicotine with benzoic acid and lactic acid, thereby moderating the odor and strong irritation of methylnicotine itself, and thus moderating the taste of the nebulizer containing methylnicotine salt. Methylnicotine salt can be well dissolved in glycerin, thus forming a stable methylnicotine salt solution. Attached Figure Description

[0029] Figure 1 is a molecular structure diagram of 2-methylnicotine provided in the embodiments of this application;

[0030] Figure 2 is a molecular structure diagram of 4-methylnicotine provided in the embodiments of this application;

[0031] Figure 3 is a molecular structure diagram of 5-methylnicotine provided in the embodiments of this application;

[0032] Figure 4 is a molecular structure diagram of 6-methylnicotine provided in the embodiments of this application. Embodiments of the present invention

[0033] It should be understood that, when used in this specification and the appended claims, the terms "comprising" and "including" indicate the presence of the described features, integrals, steps, operations, elements and / or components, but do not exclude the presence or addition of one or more other features, integrals, steps, operations, elements, components and / or collections thereof.

[0034] It should also be further understood that the term “and / or” as used in this specification and the appended claims means any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0035] For those skilled in the art, the technical features and beneficial effects of the present invention will become apparent upon reading the contents disclosed in this specification.

[0036] Nicotine is a naturally occurring alkaloid found in tobacco. It is extracted from tobacco and used to prepare the atomizing liquid in electronic atomizing devices. The atomizing components in these devices atomize the nicotine-containing liquid to generate an inhalable aerosol, satisfying the user's physiological needs and thus achieving the effect of relieving addiction.

[0037] In related technologies, the nicotine salt content in the atomizing liquid used in electronic atomizing devices varies, resulting in different addictive properties of the aerosol produced. Atomizing liquids with lower nicotine salt content have a weaker throat hit, causing users to tend to inhale more liquid to enhance the throat hit, thus leading to nicotine addiction. Conversely, atomizing liquids with higher nicotine salt content produce a strong odor and irritation, severely impacting the user's vaping experience, and high concentrations of nicotine salt can easily cause significant harm to the user.

[0038] To address the aforementioned problems, embodiments of this application provide a methyl nicotine salt for at least partially replacing nicotine in an atomizing liquid. The methyl nicotine salt comprises methyl nicotine, benzoic acid, lactic acid, and glycerin. By weight percentage, the methyl nicotine salt comprises 10%–20% methyl nicotine, 4%–6% benzoic acid, 13%–15% lactic acid, and glycerin to make up the remaining weight percentage.

[0039] In some embodiments, the weight percentage content of methyl nicotine salt may be 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, or any two of the above values, or any range between any two of the above values.

[0040] In some embodiments, the weight percentage content of benzoic acid may be 4%, 5%, 6%, or any value between any two of the above, or a range between any two of the above values.

[0041] In some embodiments, the weight percentage content of lactic acid may be 13%, 14%, 15%, or any value between any two of the above, or a range between any two of the above values.

[0042] Methyl nicotine salts are compounds formed by modifying the pyridine ring of nicotine with a methyl group. Their unique structure gives them better lipophilicity than nicotine. Reports have summarized the interaction between methyl nicotine derivatives and nicotinic acetylcholine receptors (nAChR) in the human nervous system. Methyl nicotine exhibits unique changes in the nAChR of nicotinic acetylcholine receptors, showing superior agonist properties in the response to nicotine α7 receptors and active activity in the response to nicotine α4β2 receptors. Compared to nicotine, methyl nicotine shows approximately a 7-fold increase in nAChR titer and equilibrium binding affinity to human receptors. The affinity of nicotine derivatives for human receptors decreases with increasing pyridine ring substituent size. The affinity of nicotine derivatives is determined by the lipophilicity of the pyridine ring substituent and is also related to the size of the pyridine ring substituent. The methyl group, being the smallest in size and most lipophilic, is the smallest substituent in the pyridine ring, thus making methyl nicotine a valuable alternative to nicotine.

[0043] Due to the unique physiological activity of methyl nicotine, after binding to the nicotine receptors in the human body, the impact on the user's mouth is more intense than that of nicotine. Therefore, users can still obtain a strong throat hit even with less methyl nicotine intake, thereby reducing the amount of methyl nicotine inhaled by the user and thus reducing the user's addictive dependence on electronic vaping devices.

[0044] Furthermore, since methyl nicotine itself has a pungent and irritating taste, the inventors discovered through research that converting methyl nicotine into methyl nicotine salt is more beneficial for harmonizing the flavor of the atomizing liquid. Specifically, in the embodiments of this application, methyl nicotine is reacted with two organic acids, benzoic acid and lactic acid, to generate methyl nicotine salt, with glycerol used as a solvent. Compared to other organic acids, benzoic acid and lactic acid have different and complementary functions in methyl nicotine salt. Benzoic acid and methyl nicotine share the same aromatic ring structure, resulting in a special π-π stacking intermolecular force between methyl nicotine and benzoic acid, making the binding between benzoic acid and methyl nicotine tighter. Moreover, the atomizing liquid containing methyl nicotine salt maintains a moderate pH in the aerosol formation process, thus providing users with a comfortable vaping experience. Lactic acid has a special fermented aroma, which can reduce the aroma-suppressing effect of nicotine salt, and lactic acid can also make the smoke smoother.

[0045] The lactic acid used in methyl nicotine salt has a purity of 80%, with the remainder being water. The water content in the lactic acid can further enhance the wettability of the aerosol generated by the atomization of the nebulizer.

[0046] In some embodiments, the molar mass ratio of methyl nicotine to the sum of the molar masses of benzoic acid and lactic acid is 1:(1.3~1.5). The inventors discovered that a molar mass ratio of methyl nicotine to the two organic acids of 1:(1.3~1.5) facilitates a complete acid-base neutralization reaction between methyl nicotine and the two organic acids, resulting in the complete conversion of methyl nicotine into methyl nicotine salt. This also ensures that the pH of the formed methyl nicotine salt is moderate, providing a comfortable vaping experience for the user and establishing stable intermolecular forces between methyl nicotine and benzoic acid.

[0047] In some implementations, methyl nicotine includes one or more of 2-methyl nicotine, 4-methyl nicotine, 5-methyl nicotine, and 6-methyl nicotine, as shown in Figures 1 to 4, wherein Figure 1 is a molecular structure diagram of 2-methyl nicotine, Figure 2 is a molecular structure diagram of 4-methyl nicotine, Figure 3 is a molecular structure diagram of 5-methyl nicotine, and Figure 4 is a molecular structure diagram of 6-methyl nicotine.

[0048] Embodiments of this application also provide a method for preparing methyl nicotine salt, the method comprising:

[0049] Benzoic acid, lactic acid, methylnicotine, and glycerol were placed in a reactor and stirred at a speed of 200 r / min to 500 r / min. The reaction temperature was 40℃ to 65℃, and the reaction time was 3h to 5h. After cooling to room temperature, methylnicotine salt was obtained.

[0050] The reaction involves stirring methylnicotine, lactic acid, benzoic acid, and glycerol. The process is simple, convenient, safe, and suitable for large-scale production.

[0051] The methyl nicotine salt prepared by the above method is stored in an environment with a temperature of 2℃~8℃. When stored in an environment of 2℃~8℃, nicotine is less likely to degrade, and the methyl nicotine salt is less likely to change color.

[0052] Embodiments of this application also provide an atomizing liquid containing methyl nicotine salt, comprising methyl nicotine, glycerin, a fragrance base liquid, and propylene glycol. By weight percentage, the methyl nicotine salt comprises 2%–4%, the glycerin comprises 35%–40%, the fragrance base liquid comprises 35%–40%, and the remainder is propylene glycol. It should be noted that the fragrance base liquid comprises propylene glycol solvent and fragrance, wherein the propylene glycol solvent is the main component of the fragrance base liquid.

[0053] In some embodiments, the weight percentage of methyl nicotine salt in the atomizing liquid can be 2%, 3%, 4%, or any value between two of these values, or a range between any two of these values. It is understood that, as the active ingredient in the atomizing liquid, if the weight percentage of methyl nicotine salt in the atomizing liquid is less than 2%, the aerosol generated by the atomization of the liquid will not provide the user with an effective throat hit and will have a weaker sense of satisfaction. If the weight percentage of methyl nicotine salt in the atomizing liquid is greater than 4%, it will lead to the user developing a dependence on the electronic atomizing device, failing to effectively help the user gradually quit smoking.

[0054] In some embodiments, the weight percentage of glycerin in the atomizing liquid can be 35%, 36%, 37%, 38%, 39%, 40%, or any value between any two of these values, or a range between any two of these values. Understandably, as the main component of the atomizing liquid, glycerin helps to form vapor, simulating the vapor sensation produced when actually smoking, and helps to improve the taste of the atomizing liquid, making the aerosol generated by the atomization of the liquid more mellow. Furthermore, glycerin also helps to increase the stability of the atomizing liquid. When the weight percentage of glycerin in the atomizing liquid is less than 35%, the amount of vapor formed by the aerosol generated by the atomization of the liquid is less, failing to provide the user with a sense of satisfaction. When the weight percentage of glycerin in the atomizing liquid is greater than 40%, the amount of vapor generated by the atomization of the liquid will be too dense, affecting the vaping experience. Furthermore, glycerin itself has a sweet taste; when the weight percentage of glycerin in the atomizing liquid exceeds 40%, the taste of the aerosol generated by the atomization of the liquid will also be too sweet and heavy.

[0055] In some embodiments, the flavoring base liquid constitutes 35%, 36%, 37%, 38%, 39%, 40% by weight in the atomizing liquid, or any value between any two of these values, or a range between any two of these values. The flavoring imparts various unique tastes to the atomizing liquid, such as fruity and minty flavors, increasing the pleasure of inhalation. The flavoring can be customized to suit the user's preferences, thus creating various different flavor profiles for the atomizing liquid. The aroma characteristics of the flavoring itself can also be used to neutralize any unique odors that may exist in certain components of the atomizing liquid. When the weight percentage of flavoring is less than 35%, the aerosol generated by the atomization of the liquid has a milder aroma, having less impact on the taste experience. When the weight percentage of flavoring is greater than 40%, the aerosol generated by the atomization of the liquid has an overly strong aroma, which may mask the taste of other components in the atomizing liquid and cause some irritation to the respiratory tract, thereby affecting the inhalation experience.

[0056] Propylene glycol, as a solvent component in atomizing liquid, is used to dissolve flavorings, methyl nicotine salts, and other components, and helps to adjust the taste of the aerosol.

[0057] In some embodiments, when the nicotine component in the nebulizer contains only methyl nicotine salt, the content of methyl nicotine salt in the nebulizer is 4 mg / g to 8 mg / g. Compared to related technologies, where commercially available nebulizers contain 17 mg / g to 30 mg / g of nicotine salt, using methyl nicotine salt alone as an active ingredient in the nebulizer effectively reduces the amount of active nicotine component used. Further testing and research by the inventors revealed that when the methyl nicotine salt content in the nebulizer is 4 mg / g to 8 mg / g, the aerosol generated by the nebulizer provides a stronger throat hit and satisfaction compared to the aerosol generated by commercially available nebulizers. Therefore, the user's nicotine cravings can still be satisfied even with a reduced amount of active nicotine component.

[0058] In some specific implementations, the methyl nicotine salt content is 4 mg / g, 5 mg / g, 6 mg / g, 7 mg / g, 8 mg / g, or any value between any two of these values, or a range between any two of these values. Understandably, when the methyl nicotine salt content in the vaping liquid is below 4 mg / g, the throat hit and satisfaction of the aerosol generated by the vaping liquid are weak, making it difficult to satisfy the user's cravings. When the methyl nicotine salt content in the vaping liquid is above 8 mg / g, the irritation of the aerosol generated by the vaping liquid is strong, thus affecting the user's vaping experience.

[0059] Some embodiments of this application also provide an aerosol containing methyl nicotine salt. This aerosol contains both nicotine salt and methyl nicotine salt, wherein the weight percentage of methyl nicotine salt is less than the weight percentage of nicotine salt. Because methyl nicotine salt reacts more strongly with nicotinic acetylcholine receptors in the human nervous system, adding a small amount of methyl nicotine salt to an aerosol containing nicotine salt can provide the user with a noticeable throat hit and satisfaction. Specifically, the aerosol includes methyl nicotine salt, nicotine salt, flavoring, and propylene glycol. Based on the weight percentage of the aerosol, the nicotine salt is 8.5%–15%, the methyl nicotine salt is 0.5%–1%, the glycerin is 35%–40%, the flavoring base is 35%–40%, and propylene glycol makes up the balance.

[0060] In some specific embodiments, the weight percentage of nicotine salt is 8.5%, 9%, 9.6%, 10%, 10.4%, 11%, 11.8%, 12%, 12.7%, 14%, 14.6%, 15%, or any value between any two of the above, or a range between any two of the above values. It is understood that, as the main active component in the vaping liquid, if the nicotine salt content is less than 8.5%, the throat hit and satisfaction of the aerosol generated by the vaping liquid are insufficient, affecting the smoking experience. When the nicotine salt content is greater than 15%, the aerosol generated by the vaping liquid is highly irritating, and this also does not comply with the national standards for the amount of nicotine added to nicotine preparations.

[0061] In some specific embodiments, the weight percentage of methyl nicotine salt is 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, or any value between any two of the above, or a range between any two of the above values. It is understood that methyl nicotine salt, added as an additive to a nicotine-containing e-liquid, primarily enhances the throat hit and satisfaction of the aerosol. While maintaining a certain weight percentage of nicotine salt, if the weight percentage of methyl nicotine salt is less than 0.5%, the methyl nicotine salt content is too low to exert its effect. When the weight percentage of methyl nicotine salt is greater than 1%, the methyl nicotine salt content is too high, which will result in a more irritating aerosol generated by the e-liquid, thus affecting the user's vaping experience.

[0062] Furthermore, the content ratio of glycerin, the content ratio of fragrance and flavor base liquid, and the content ratio of glycerin can be determined with reference to the requirements and regulations of the above embodiments.

[0063] In some embodiments, methyl nicotine salt is added to commercially available nicotine salt atomizing liquid, wherein the content of methyl nicotine salt is 1 mg / g to 2 mg / g, and the content of nicotine salt in the commercially available atomizing liquid is 17 mg / g to 30 mg / g. It is understandable that, while maintaining a certain range of nicotine salt content in the commercially available atomizing liquid, if the content of methyl nicotine salt added as an additive is less than 1 mg / g, the methyl nicotine salt content is too low to exert its effect. If the content of methyl nicotine salt added as an additive exceeds 2 mg / g, the aerosol generated by the atomization of the atomizing liquid will be more irritating, which is detrimental to improving the user experience.

[0064] In some embodiments, the flavorings used in the flavoring base liquid include one or more of the following: tobacco flavoring, strawberry flavoring, apple flavoring, mango flavoring, grape flavoring, sweet orange flavoring, lemon flavoring, lemongrass flavoring, peppermint flavoring, and rose flavoring. The specific types of flavorings added to the atomizing liquid can be added according to the user's preference.

[0065] This application also provides an atomizer in its embodiments. The atomizer includes a liquid reservoir and an atomizing component. The liquid reservoir is used to contain the atomizing liquid provided in the above embodiments, and the atomizing component is used to atomize the atomizing liquid to generate an aerosol. The liquid reservoir and the atomizing component can be configured with a detachable connection structure, and the liquid reservoir can be sold separately as a consumable. Alternatively, the liquid reservoir and the atomizing component can be configured with a non-detachable connection structure. The atomizing component can be one or more of the following in the related art: ceramic core atomizing component, ultrasonic atomizing component, and cotton core atomizing component.

[0066] An embodiment of this application also provides an electronic atomizing device, which includes an atomizer and a power supply component, the power supply component providing power to the atomizer. The atomizer and the power supply component can be configured as a detachable connection structure, or they can be configured as a non-detachable connection structure.

[0067] The present application will be described in further detail below with reference to specific embodiments. The purpose of this description is merely illustrative and not intended to limit the scope of the present application.

[0068] Example

[0069] Examples 1-4: Different mass ratios of methylnicotine to benzoic acid and lactic acid

[0070] Table 1. Ratios of different methyl nicotine to organic acids

[0071]

[0072] As shown in Table 1, different molecular structures of methylnicotine result in different ratios of methylnicotine, benzoic acid, and lactic acid during the preparation of methylnicotine salts. The ratio of the molar mass of methylnicotine to the sum of the molar masses of benzoic acid and lactic acid varies depending on the substitution position of the methyl group. For example, the ratio of the molar mass of 2-methylnicotine to the sum of the molar masses of benzoic acid and lactic acid is 1.37, while the ratio of the molar mass of 6-methylnicotine to the sum of the molar masses of benzoic acid and lactic acid is 1.45.

[0073] Example 5 provides a method for preparing methyl nicotine salt.

[0074] 20g of 2-methylnicotine, 4.3g of benzoic acid, 13.6g of lactic acid and 62.1g of glycerol were placed in a reactor. The reaction temperature was controlled at 40℃~65℃, the stirring speed was 300r / min, and the reaction time was 4h to obtain methylnicotine salt.

[0075] Example 6 provides a method for preparing an atomizing fluid containing methyl nicotine salt.

[0076] Add 3g of methyl nicotine salt, 40g of glycerin, 12g of tobacco flavoring, 31g of peppermint flavoring, and 14g of propylene glycol to a container and stir well.

[0077] Examples 7-10 provide four different formulations of atomizing fluids containing methyl nicotine salts.

[0078] Table 2 Formulations of atomizing fluids containing methylnicotine salts

[0079]

[0080] Example 11 provides a method for preparing an atomizing fluid containing methylnicotine salt.

[0081] Add 99.1g of commercially available finished atomizing liquid and 0.9g of methyl nicotine salt from Example 1 to a container and stir until well mixed.

[0082] Examples 12-15 provide a formulation for an atomizing fluid containing methyl nicotine salt.

[0083] Table 3 Formulations of atomizing fluids with added methyl nicotine salts

[0084]

[0085] Detection methods

[0086] The atomizing liquids prepared in Examples 7-10 and 12-15 above, as well as commercially available atomizing liquids 1-4, were tasted by 20 professional electronic atomizing device sensory evaluators. The six evaluation indicators shown in Table 4 were then evaluated: irritation, satisfaction, throat hit, aroma harmony, aroma persistence, and off-flavors. The evaluation results are shown in Table 5.

[0087] Table 4 Evaluation Indicators for Atomizing Fluid

[0088]

[0089] Table 5 Sensory evaluation of Examples 7-10, Examples 12-15, and commercially available atomizing liquids 1-4

[0090] Example 1: Throat hit, satisfaction, comfort, aroma harmony, aroma persistence, off-flavors. Example 7: 9.4, 14.3, 9.5, 13.9, 9.5, 9.5. Example 8: 9.4, 14.2, 9.4, 14.1, 9.2, 9.6. Example 9: 9.6, 14.3, 9.6, 13.8, 9.4, 9.3. Example 10: 9.2, 14.5, 9.3, 14.1, 9.4, 9.5. Example 12: 9.6, 14.2, 9.5, 14.3, 9.3, 9.6. Example 13: 9.5, 14.3. 9.4 14.4 9.5 9.2 Example 1 49.5 14.4 9.6 14.3 9.3 9.4 Example 1 59.6 14.5 9.2 14.5 9.5 9.3 Atomizing fluid 18.6 13.5 9.3 14.3 9.4 9.5 Atomizing fluid 29.1 13.6 9.5 14.6 9.3 9.3 Atomizing fluid 38.8 13.2 9.6 14.5 9.4 9.5 Atomizing fluid 48.5 13.4 9.4 14.3 9.2 9.4

[0091] According to the sensory effect evaluation results in Table 5, comparing the throat hit and satisfaction data of Examples 7-10 and 12-15 with those of nebulizers 1-4 reveals that the nebulizer containing methyl nicotine salt has a stronger throat hit and satisfaction compared to existing commercially available nebulizers. Furthermore, comparing the throat hit and satisfaction data of Examples 12-15 with those of nebulizers 1-4 shows that adding a small amount of methyl nicotine salt to existing nebulizers significantly improves the throat hit and satisfaction, thus helping to reduce nicotine usage.

[0092] According to the sensory effect evaluation results in Table 5, comparing the evaluation data of throat hit and satisfaction in Examples 7-10 with the rating data of throat hit and satisfaction in Examples 12-15, and combining the formulation tables of the nebulizer liquids for Examples 7-10 provided in Table 2 and the formulation tables of the nebulizer liquids for Examples 12-15 provided in Table 3, it can be seen that the methyl nicotine content in Examples 7-10 provided in Table 2 is 4 mg / g to 8 mg / g, and the nicotine content in Examples 12-15 provided in Table 3 is 17 mg / g to 30 mg / g. Examples 7-10, using a low content of methyl nicotine salt, can produce the throat hit and satisfaction experienced in Examples 11-14, which use a high content of nicotine salt.

[0093] According to the sensory effect evaluation results in Table 5, comparing the data on comfort, aroma harmony, aroma persistence, and off-flavors of Examples 7-10 and Examples 12-15 with the data on comfort, aroma harmony, aroma persistence, and off-flavors of Atomizing Liquids 1-4, it was found that after adding methyl nicotine salt, methyl nicotine salt can be blended with different fragrances and flavorings. The aerosol produced by the atomizing liquid has various harmonious odors, a comfortable inhalation experience, harmonious aroma, and outstanding aroma characteristics. It is full and delicate, without any off-flavors, and has a fast craving speed.

Claims

1. A methyl-nicotine salt configured to configure an atomized liquid, the methyl-nicotine salt comprising, in terms of weight percentage: methyl-nicotine 10%-20%; benzoic acid 4%-6%; lactic acid 13%-15%; glycerol the rest.

2. The methylnicotine salt of claim 1, wherein, The methyl-nicotine comprises one or more of 2-methyl-nicotine, 4-methyl-nicotine, 5-methyl-nicotine and 6-methyl-nicotine.

3. The methylnicotine salt of claim 2, wherein, The molar mass of the methyl-nicotine is 1: (1.3-1.5) of the sum of the molar mass of the lactic acid and the benzoic acid. 4.A preparation method of the methyl-nicotine salt of claim 1, the preparation method comprising: putting benzoic acid, lactic acid, methyl-nicotine, glycerol into a reactor and stirring at a stirring speed of 200 r / min-500 r / min, a reaction temperature of 40 ℃-65 ℃ and a reaction time of 3 h-5 h, and cooling to room temperature to obtain the methyl-nicotine salt. 5.An atomized liquid containing the methyl-nicotine salt of any one of claims 1-3, the atomized liquid comprising, in terms of weight percentage: methyl-nicotine salt 2%-4%; glycerol 35%-40%; flavor base 35%-40%; propylene glycol the rest.

6. The atomized liquid of claim 5 wherein, The content of the methyl-nicotine salt is 4 mg / g-8 mg / g.

7. An atomized liquid containing the methylnicotine salt of any one of claims 1-3, wherein, The atomized liquid comprises, in terms of weight percentage: methyl-nicotine salt 0.5%-1%; nicotine salt 8.5%-15%; glycerol 13%-15%; flavor base 35%-40%; propylene glycol the rest.

8. The atomized liquid of claim 7 wherein, The content of the methyl-nicotine salt is 1 mg / g-2 mg / g, and / or the content of the nicotine salt is 17 mg / g-30 mg / g.

9. The atomized liquid of claim 5 or 7, wherein, The flavor base comprises propylene glycol and flavor, the flavor being dissolved in the propylene glycol, the flavor comprising one or more of tobacco flavor, strawberry flavor, apple flavor, mango flavor, grape flavor, sweet orange flavor, lemon flavor, citronella flavor, mint flavor and rose flavor. 10.An atomizer comprising a liquid storage and an atomization assembly, the liquid storage being configured to contain an atomized liquid, the atomization assembly being configured to atomize the atomized liquid to generate an aerosol, the atomized liquid comprising, in terms of weight percentage: methyl-nicotine salt 2%-4%; glycerol 35%-40%; flavor base 35%-40%; propylene glycol the rest.

11. The atomizer of claim 10, wherein, The content of the methyl-nicotine salt is 4 mg / g-8 mg / g. 12.An atomizer comprising a liquid storage and an atomization assembly, the liquid storage being configured to contain an atomized liquid, the atomization assembly being configured to atomize the atomized liquid to generate an aerosol, the atomized liquid comprising, in terms of weight percentage: methyl-nicotine salt 0.5%-1%; nicotine salt 8.5%-15%; glycerol 13%-15%; flavor base 35%-40%; propylene glycol the rest.

13. The atomizer of claim 12, wherein, The content of the methyl-nicotine salt is 1 mg / g-2 mg / g, and / or the content of the nicotine salt is 17 mg / g-30 mg / g.

14. The atomizer of claim 10 or 12, wherein, The perfume base fluid includes propylene glycol and a perfume, the perfume being dissolved in the propylene glycol, the perfume including one or more of tobacco flavor, strawberry flavor, apple flavor, mango flavor, grape flavor, sweet orange flavor, lemon flavor, citronella flavor, mint flavor, rose flavor.

15. An electronic atomization device comprising the atomizer of any one of claims 10-14 and a power supply assembly to provide power to the atomizer.

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