Plant-derived protein-based nanoparticle composition for cosmetics

Abstract

The purpose of the present invention is to provide a nanoparticle composition for cosmetics. The nanoparticle composition for cosmetics comprises zein, hyaluronic acid, and lecithin, and thus nanoparticles can be stably and efficiently prepared, water-insoluble components can be stably dissolved in water, and the nanoparticles themselves can exhibit skin improvement efficacy.

Description

Nanoparticle composition for cosmetic products based on plant-derived proteins

[0001] The present application relates to a nanoparticle composition for cosmetics.

[0002] As consumer interest in skin health grows, research is continuing on the efficacy of various ingredients that can support skin health. Research has examined the effects of various water-poorly soluble substances, such as flavonoid compounds and fat-soluble vitamins. These substances have been found to have antioxidant, anti-inflammatory, moisturizing, skin elasticity-boosting, and skin barrier-strengthening properties.

[0003] Cosmetics designed to improve skin health are typically applied to the skin after cleansing, and are often formulated in lightweight formulations that provide hydration. However, despite their diverse benefits, poorly water-soluble substances are inherently insoluble in water. Therefore, they must be dissolved in oils for use. This complicates the process of formulating these substances into moisturizing formulations. Therefore, there is a pressing need to develop compositions that can stably dissolve poorly water-soluble substances in water.

[0004] The purpose of this application is to provide a nanoparticle composition for cosmetics.

[0005] According to an embodiment of the present application, a cosmetic nanoparticle composition is provided. The cosmetic nanoparticle composition may include zein, hyaluronic acid, and lecithin.

[0006] Additionally, the above-mentioned zein, hyaluronic acid and lecithin may be included in amounts of less than 0.6 wt%, less than 0.125 wt% and less than 0.3 wt%, respectively, relative to the total weight of the composition.

[0007] Additionally, the above-mentioned zein, hyaluronic acid and lecithin may be included in amounts of 0.1 to 0.5 wt%, 0.001 to 0.12 wt% and 0.05 to 0.28 wt%, respectively, relative to the total weight of the composition.

[0008] In addition, the cosmetic nanoparticle composition may include nanoparticles including a nanoparticle film and an internal matrix, and the nanoparticle film may include the zein, the hyaluronic acid, and the lecithin.

[0009] Additionally, the internal substrate may include a water-insoluble substance.

[0010] In addition, the water-soluble substance may have at least one of the following effects: skin whitening, skin elasticity improvement, skin wrinkle improvement, skin regeneration, skin irritation relief, anti-inflammation, anti-oxidation, anti-aging, antibacterial, skin moisturizing, and skin barrier strengthening.

[0011] Additionally, the cosmetic nanoparticle composition further includes a solvent, and the solvent may include alcohol and water.

[0012] Additionally, the cosmetic nanoparticle composition may contain water in an amount of 50 wt% or more relative to the total weight of the composition.

[0013] According to an embodiment of the present application, a cosmetic composition is provided. The cosmetic composition may include the cosmetic nanoparticle composition.

[0014] According to the embodiments of the present application, nanoparticles can be stably and efficiently manufactured using zein, hyaluronic acid, and lecithin, and the water-poorly soluble component can be stably dissolved in water by loading the water-poorly soluble component into the nanoparticles.

[0015] In addition, according to the embodiments of the present application, in addition to the efficacy of the internal substrate loaded in the nanoparticles, the nanoparticles themselves can exhibit skin improvement efficacy, and thus the skin improvement effect can be doubled.

[0016] The effects that can be obtained in the embodiments of the present application are not limited to the effects mentioned above, and other effects not mentioned can be clearly understood by a person having ordinary skill in the technical field to which the present application belongs from the description below.

[0017] Figure 1 is a particle size distribution graph of a cosmetic nanoparticle composition according to an example of the present application.

[0018] Figure 2 is a particle size distribution graph of a cosmetic nanoparticle composition according to a comparative example of the present application.

[0019] The structural or functional descriptions of the embodiments disclosed in this specification are merely illustrative for the purpose of explaining embodiments according to the technical concept of the present application. Furthermore, embodiments according to the technical concept of the present application may be implemented in various forms other than those disclosed herein. Furthermore, the technical concept of the present application is not limited to the embodiments described herein.

[0020] Among the properties mentioned in this specification, if the measurement temperature affects the properties, the properties are properties measured at room temperature and pressure unless otherwise specified.

[0021] Unless otherwise specified, the properties mentioned in this specification may basically follow the SI unit system. For example, weight may use the kg unit, and length may use the m unit.

[0022] The term "room temperature" used herein refers to the natural temperature that is not heated or cooled, and may mean, for example, any temperature within the range of 10°C to 30°C, for example, a temperature that is about 15°C or higher, about 18°C ​​or higher, about 20°C or higher, about 23°C or higher, about 27°C or lower, or 25°C. Unless specifically defined herein, the unit of temperature is Celsius (°C).

[0023] The term "relatively high temperature compared to room temperature" used herein means a temperature higher than the room temperature, and may mean, for example, any temperature within the range of 30°C to 50°C, for example, a temperature of about 35°C or higher, about 40°C or higher, or about 45°C or lower.

[0024] Among the properties mentioned in this specification, if the measurement pressure affects the property, the property is a property measured at atmospheric pressure unless otherwise specified. The term atmospheric pressure used in this specification refers to the natural pressure that is neither pressurized nor depressurized, and typically refers to atmospheric pressure within the range of approximately 700 mmHg to 800 mmHg.

[0025] The terms a to b used in this specification mean a and b inclusive and within the range between a and b. For example, including a to b by weight means including within the range of a to b by weight.

[0026] Throughout this specification, values ​​expressed in range format should be interpreted flexibly to include not only the numerical values ​​explicitly stated as limits of such range, but also every individual numerical value or subrange subsumed within that range, as if each numerical value and subrange were expressly stated. For example, a range of "from about 0.1% to about 5%" or "from about 0.1% to 5%" should be interpreted to include not only from about 0.1% to about 5%, but also individual values ​​(e.g., 1%, 2%, 3%, and 4%) and subranges (e.g., 0.1% to 0.5%, 1.1% to 2.2%, 3.3% to 4.4%) within the indicated range. Unless otherwise indicated, reference to "from about X to Y" has the same meaning as "from about X to about Y." Similarly, unless otherwise indicated, reference to “about X, Y, or about Z” has the same meaning as “about X, about Y, or about Z.”

[0027] The terms "about" or "approximately" as used herein mean that dimensions, sizes, formulations, parameters, shapes, and other quantities and characteristics may not be exact and may be approximate and / or greater or less, if necessary, reflecting tolerances, conversion factors, rounding, measurement errors, and other factors known to those skilled in the art. "About" or "approximately" applies to dimensions, sizes, formulations, parameters, shapes, or other quantities or characteristics described herein, generally whether or not explicitly stated. The term "about" as used herein allows for a degree of variability in a given value or range, for example, within 10%, within 5%, or within 1% of the stated value or a stated range limit, and includes the stated exact value or range.

[0028] If a method for measuring or evaluating a specific dimension, size, formulation, parameter, shape, or other quantity or characteristic is not described in this specification, a person skilled in the art can easily recognize a conventionally known method for measuring or evaluating the same, or can easily derive the method by referring to a known technology known prior to the filing date of this specification.

[0029] The terminology used in this specification is for the purpose of describing embodiments and is not intended to limit or restrict the present application. Singular expressions include plural expressions unless the context clearly dictates otherwise. Furthermore, numbers used in this specification (e.g., "first," "second," etc.) are merely identifiers used to distinguish one component from another.

[0030] In this specification, when a part is said to be connected to another part, this includes not only direct connections but also indirect connections with other components intervening. Furthermore, when a part is said to include a component, this does not exclude other components, but rather includes other components, unless otherwise specifically stated.

[0031] Furthermore, the term "or" in this application is intended to mean an inclusive "or" rather than an exclusive "or." That is, unless otherwise specified or clear from context, "X utilizes A or B" is intended to mean either of the natural inclusive permutations. That is, if X utilizes A; X utilizes B; or X utilizes both A and B, "X utilizes A or B" can apply to any of the above cases. Furthermore, the term "and / or" as used herein should be understood to refer to and encompass all possible combinations of one or more of the associated configurations listed.

[0032]

[0033] According to an embodiment of the present application, a cosmetic nanoparticle composition is provided. In the present application, the term "nanoparticle" refers to a fine particle having a size of 1 to 1,000 nm, and the term "nanoparticle composition" refers to a composition comprising nanoparticles. The cosmetic nanoparticle composition may include zein, hyaluronic acid, and lecithin.

[0034] Zein is a natural protein extracted from corn gluten, and its safety has been verified by the U.S. Food and Drug Administration. Zein can self-assemble into nanoparticles under specific conditions. Specifically, zein is highly soluble in ethanol or alkaline solutions, and when combined with neutral water in solution, it self-assembles into spherical nanoparticle structures.

[0035] Hyaluronic acid is a natural substance found in high concentrations in connective tissue and skin. Hyaluronic acid possesses an exceptional ability to attract and retain water molecules, providing moisture retention and moisturizing benefits.

[0036] Lecithin is one of the phospholipids that make up human cell membranes and is a substance that has moisturizing, skin barrier strengthening, and antioxidant properties.

[0037] According to an embodiment of the present application, by forming nanoparticles by combining zein, hyaluronic acid, and lecithin, not only can nanoparticles be formed stably and efficiently, but also various skin improvement effects can be imparted to the formed nanoparticles.

[0038] In some embodiments, zein may be included in an amount of less than 0.6 wt% relative to the total weight of the composition. If zein is included in an amount greater than 0.6 wt%, the particle size may become excessively large, preventing it from penetrating the skin and remaining on the surface, thereby reducing the skin penetration effect. For example, zein may be included in an amount of 0.55 wt% or less, 0.5 wt% or less, 0.45 wt% or less, 0.4 wt% or less, or 0.35 wt% or less relative to the total weight of the composition.

[0039] In some embodiments, zein may be present in an amount of at least 0.1 wt% relative to the total weight of the composition. If zein is present in an amount of less than 0.1 wt%, nanoparticles may not be formed properly, and even if nanoparticles are formed, they may not be formed to a consistent size. For example, zein may be present in an amount of at least 0.1 wt%, at least 0.15 wt%, at least 0.2 wt%, or at least 0.25 wt% relative to the total weight of the composition.

[0040] In an embodiment, Jane may be included in an amount of 0.1 to 0.5 wt% relative to the total weight of the composition. For example, zein may be present in an amount of 0.1 to 0.5 wt%, 0.15 to 0.5 wt%, 0.2 to 0.5 wt%, 0.25 to 0.5 wt%, 0.1 to 0.45 wt%, 0.15 to 0.45 wt%, 0.2 to 0.45 wt%, 0.25 to 0.45 wt%, 0.1 to 0.4 wt%, 0.15 to 0.4 wt%, 0.2 to 0.4 wt%, 0.25 to 0.4 wt%, 0.1 to 0.35 wt%, 0.15 to 0.35 wt%, 0.2 to 0.35 wt%, or 0.25 to 0.35 wt% relative to the total weight of the composition.

[0041] In some embodiments, hyaluronic acid may be included in an amount of less than 0.125 wt% relative to the total weight of the composition. If hyaluronic acid is included in an amount greater than 0.125 wt%, the high-temperature stability of the nanoparticles may be reduced. For example, hyaluronic acid may be included in an amount of 0.12 wt% or less, 0.115 wt% or less, 0.11 wt% or less, or 0.105 wt% or less relative to the total weight of the composition.

[0042] In an embodiment, hyaluronic acid may be included in an amount of 0.001 wt% or more relative to the total weight of the composition. If hyaluronic acid is included in an amount of less than 0.001 wt%, nanoparticles may not be formed properly, or nanoparticles may clump together to form sediment. For example, hyaluronic acid may be included in an amount of 0.001 wt% or more, 0.01 wt% or more, 0.015 wt% or more, 0.02 wt% or more, 0.025 wt% or more, 0.03 wt% or more, 0.035 wt% or more, 0.04 wt% or more, 0.045 wt% or more, 0.05 wt% or more, 0.055 wt% or more, 0.06 wt% or more, 0.065 wt% or more, 0.07 wt% or more, 0.075 wt% or more, 0.08 wt% or more, 0.085 wt% or more, 0.09 wt% or more, or 0.095 wt% or more relative to the total weight of the composition.

[0043] In an embodiment, hyaluronic acid may be included in an amount of 0.001 to 0.12 wt% relative to the total weight of the composition. For example, hyaluronic acid is present in an amount of 0.001 to 0.12 wt%, 0.01 to 0.12 wt%, 0.015 to 0.12 wt%, 0.02 to 0.12 wt%, 0.025 to 0.12 wt%, 0.03 to 0.12 wt%, 0.035 to 0.12 wt%, 0.04 to 0.12 wt%, 0.045 to 0.12 wt%, 0.05 to 0.12 wt%, 0.055 to 0.12 wt%, 0.06 to 0.12 wt%, 0.065 to 0.12 wt%, 0.07 to 0.12 wt%, 0.075 to 0.12 wt%, 0.08 to 0.12 wt%, 0.085 to 0.12 wt%, 0.09 to 0.12 wt%, 0.095 to 0.12 wt%, 0.001 to 0.115 wt%, 0.01 to 0.115 wt%, 0.015 to 0.115 wt%, 0.02 to 0.115 wt%, 0.025 to 0.115 wt%, 0.03 to 0.115 wt%, 0.035 to 0.115 wt%, 0.04 to 0.115 wt%, 0.045 to 0.115 wt%, 0.05 to 0.115 wt%, 0.055 to 0.115 wt%, 0.06 to 0.115 wt%, 0.065 to 0.115 wt%, 0.07 to 0.115 wt%, 0.075 to 0.115 wt%, 0.08 to 0.115 wt%, 0.085 to 0.115 wt%, 0.09 to 0.115 wt%, 0.095 to 0.115 wt%, 0.001 to 0.11 wt%, 0.01 to 0.11 wt%, 0.015 to 0.11 wt%, 0.02 to 0.11 wt%, 0.025 to 0.11 wt%, 0.03 to 0.11 wt%, 0.035 to 0.11 wt%, 0.04 to 0.11 wt%, 0.045 to 0.11 wt%, 0.05 to 0.11 wt%, 0.055 to 0.11 wt%, 0.06 to 0.11 wt%, 0.065 to 0.11 wt%, 0.07 to 0.11 wt%, 0.075 to 0.11 wt%, 0.08 to 0.11 wt%, 0.085 to 0.11 wt%, 0.09 to 0.11 wt%, 0.095 to 0.11 wt%, 0.001 to 0.105 wt%, 0.01 to 0.105 wt%, 0.015 to 0.105 wt%, 0.02 to 0.105 wt%, 0.025 to 0.105 wt%, 0.03 to 0.105 wt%, 0.035 to 0.105 wt%, 0.04 to 0.105 % by weight, 0.045 to 0.105 wt%, 0.05 to 0.105 wt%, 0.055 to 0.105 wt%, 0.06 to 0.105 wt%, 0.065 to 0.105 wt%, 0.07 to 0.105 wt%, 0.075 to 0.105 wt%, 0.08 to 0.105 wt%, 0.085 to 0.105 wt%, 0.09 to 0.105 wt%, or 0.095 to 0.105 wt%.

[0044] In the embodiment, lecithin may be included in an amount of less than 0.3 wt% based on the total weight of the composition. If lecithin is included in an amount of more than 0.3 wt%, lecithin may not be properly dissolved in the solvent during the manufacturing process of the nanoparticles, making it impossible to manufacture the nanoparticles or causing precipitation in the manufactured composition. For example, lecithin may be included in an amount of 0.28 wt% or less, 0.27 wt% or less, 0.26 wt% or less, 0.25 wt% or less, 0.24 wt% or less, 0.23 wt% or less, 0.22 wt% or less, or 0.21 wt% or less based on the total weight of the composition.

[0045] In an embodiment, lecithin may be included in an amount of 0.05 wt% or more relative to the total weight of the composition. If lecithin is included in an amount of less than 0.05 wt%, the salt stability and high-temperature long-term stability of the nanoparticles may deteriorate. For example, lecithin may be included in an amount of 0.05 wt% or more, 0.06 wt% or more, 0.07 wt% or more, 0.08 wt% or more, 0.09 wt% or more, 0.1 wt% or more, 0.11 wt% or more, 0.12 wt% or more, 0.13 wt% or more, 0.14 wt% or more, 0.15 wt% or more, 0.16 wt% or more, 0.17 wt% or more, 0.18 wt% or more, or 0.19 wt% or more relative to the total weight of the composition.

[0046] In an embodiment, lecithin may be included in an amount of 0.05 to 0.28 wt% relative to the total weight of the composition. For example, lecithin is present in an amount of 0.05 to 0.28 wt%, 0.06 to 0.28 wt%, 0.07 to 0.28 wt%, 0.08 to 0.28 wt%, 0.09 to 0.28 wt%, 0.1 to 0.28 wt%, 0.11 to 0.28 wt%, 0.12 to 0.28 wt%, 0.13 to 0.28 wt%, 0.14 to 0.28 wt%, 0.15 to 0.28 wt%, 0.16 to 0.28 wt%, 0.17 to 0.28 wt%, 0.18 to 0.28 wt%, 0.19 to 0.28 wt%, 0.05 to 0.27 wt%, 0.06 to 0.27 wt%, 0.07 to 0.27 wt%, 0.08 to 0.27 wt%, 0.09 to 0.27 wt%, 0.1 to 0.27 wt%, 0.11 to 0.27 wt%, 0.12 to 0.27 wt%, 0.13 to 0.27 wt%, 0.14 to 0.27 wt%, 0.15 to 0.27 wt%, 0.16 to 0.27 wt%, 0.17 to 0.27 wt%, 0.18 to 0.27 wt%, 0.19 to 0.27 wt%, 0.05 to 0.26 wt%, 0.06 to 0.26 wt%, 0.07 to 0.26 wt%, 0.08 to 0.26 wt%, 0.09 to 0.26 wt%, 0.1 to 0.26 wt%, 0.11 to 0.26 wt%, 0.12 to 0.26 wt%, 0.13 to 0.26 wt%, 0.14 to 0.26 wt%, 0.15 to 0.26 wt%, 0.16 to 0.26 wt%, 0.17 to 0.26 wt%, 0.18 to 0.26 wt%, 0.19 to 0.26 wt%, 0.05 to 0.25 wt%, 0.06 to 0.25 wt%, 0.07 to 0.25 wt%, 0.08 to 0.25 wt%, 0.09 to 0.25 wt%, 0.1 to 0.25 wt%, 0.11 to 0.25 wt%, 0.12 to 0.25 wt%, 0.13 to 0.25 wt%, 0.14 to 0.25 wt%, 0.15 to 0.25 wt%, 0.16 to 0.25 wt%, 0.17 to 0.25 wt%, 0.18 to 0.25 wt%, 0.19 to 0.25 wt%, 0.05 to 0.24 wt%, 0.06 to 0.24 wt%, 0.07 to 0.24 wt%, 0.08 to 0.24 wt%, 0.09 to 0.24 wt%, 0.1 to 0.24 wt%, 0.11 to 0.24 wt%, 0.12 to 0.24 wt%, 0.13 to 0.24 wt%, 0.14 to 0.24 wt%, 0.15 to 0.24 wt%, 0.16 to 0.24 wt%, 0.17 to 0.24 wt%, 0.18 to 0.24 wt%, 0.19 to 0.24 wt%, 0.05 to 0.23 wt%, 0.06 to 0.23 wt%, 0.07 to 0.23 wt%, 0.08 to 0.23 wt%, 0.09 to 0.23 wt%, 0.1 to 0.23 wt%, 0.11 to 0.23 wt%, 0.12 to 0.23 wt%, 0.13 to 0.23 wt%, 0.14 to 0.23 wt%, 0.15 to 0.23 wt%, 0.16 to 0.23 wt%, 0.17 to 0.23 wt%, 0.18 to 0.23 wt%, 0.19 to 0.23 wt%, 0.05 to 0.22 wt%, 0.06 to 0.22 wt%, 0.07 to 0.22 wt%, 0.08 to 0.22 wt%, 0.09 to 0.22 wt%, 0.1 to 0.22 wt%, 0.11 to 0.22 wt%, 0.12 to 0.22 wt%, 0.13 to 0.22 wt%, 0.14 to 0.22 wt%, 0.15 to 0.22 wt%, 0.16 to 0.22 wt%, 0.17 to 0.22 wt%, 0.18 to 0.22 wt%, 0.19 to 0.22 wt%, 0.05 to 0.21 wt%, 0.06 to 0.21 wt%, 0.0.7 to 0.21 wt%, 0.08 to 0.21 wt%, 0.09 to 0.21 wt%, 0.1 to 0.21 wt%, 0.11 to 0.21 wt%, 0.12 to 0.21 wt%, 0.13 to 0.21 wt%, 0.14 to 0.21 wt%, 0.15 to 0.21 wt%, 0.16 to 0.21 wt%, 0.17 to 0.21 wt%, 0.18 to 0.21 wt% or 0.19 to 0.21 wt% may be included.

[0047] In an embodiment, zein, hyaluronic acid and lecithin may be included in amounts of less than 0.6 wt%, less than 0.125 wt% and less than 0.3 wt%, respectively, relative to the total weight of the composition.

[0048] In an embodiment, zein, hyaluronic acid and lecithin may be included in amounts of 0.1 to 0.5 wt%, 0.001 to 0.12 wt% and 0.05 to 0.28 wt%, respectively, relative to the total weight of the composition.

[0049] In embodiments, zein, hyaluronic acid, and lecithin (and poorly water-soluble substances) can be substantially / substantially dissolved in water. For example, the cosmetic nanoparticle composition can comprise at least 50 wt% water relative to the total weight of the composition. For example, the cosmetic nanoparticle composition can comprise at least 50 wt%, at least 55 wt%, at least 60 wt%, at least 65 wt%, at least 70 wt%, at least 75 wt%, or at least 80 wt% water relative to the total weight of the composition.

[0050] In an embodiment, a cosmetic nanoparticle composition may include nanoparticles. The nanoparticles may include a nanoparticle membrane and an internal matrix.

[0051] In an embodiment, the nanoparticle film may include zein, hyaluronic acid, and lecithin. By including zein, hyaluronic acid, and lecithin, the nanoparticle film can encapsulate and stably support the internal matrix. Furthermore, since the nanoparticle film includes zein, a corn-derived protein, and hyaluronic acid and lecithin, which have moisturizing and skin barrier strengthening properties, it can exhibit various effects of a cosmetic composition on its own, without the need for additional active ingredients.

[0052] In an embodiment, the inner matrix may include a water-poorly soluble substance. The water-poorly soluble substance is supported in the inner matrix surrounded by a nanoparticle film, thereby enabling the water-poorly soluble substance to be stably delivered to the target.

[0053] In some embodiments, the water-insoluble substance may have skin-improving properties. For example, the water-insoluble substance may have at least one of the following effects: skin whitening, skin elasticity improvement, skin wrinkle improvement, skin regeneration, skin irritation relief, anti-inflammation, antioxidant, anti-aging, antibacterial, skin moisturizing, and skin barrier strengthening.

[0054] In an embodiment, the poorly water-soluble substance may include at least one selected from flavonoids and fat-soluble vitamins. For example, the poorly water-soluble substance may include resveratrol, ascorbyl palmitate, curcumin, quercetin, rutin, EGCG (Epigallocatechine Gallate), TECA (Titrated Extract of Centella Asiatica; containing madecassic acid, asiaticoside, and asiatic acid), retinol, retinyl palmitate, and the like.

[0055] In an embodiment, the water-insoluble substance may be included in an amount of 0.01 to 0.05 wt% relative to the total weight of the composition. Within this range, the water-insoluble substance can be stably contained within the nanoparticles and exhibit sufficient effective efficacy.

[0056] In an embodiment, the size of the nanoparticles may be 100 to 220 nm. Within this range, the particles can be stably maintained for a long time, efficiently carry active ingredients such as water-insoluble substances, and efficiently penetrate the skin. For example, the size of the nanoparticles may be 100 to 220 nm, 110 to 220 nm, 120 to 220 nm, 130 to 220 nm, 140 to 220 nm, 150 to 220 nm, 160 to 220 nm, 170 to 220 nm, 180 to 220 nm, 190 to 220 nm, 200 to 220 nm, 210 to 220 nm, 100 to 210 nm, 110 to 210 nm, 120 to 210 nm, 130 to 210 nm, 140 to 210 nm, 150 to 210 nm, 160 to 210 nm, 170 to 210 nm, 180 to 210 nm, 190 to 210 nm, 200 to 210 nm, 100 to 200 nm, 110 to 200 nm, 120 to 200 nm, 130 to 200 nm, 140 to 200 nm, 150 to 200 nm, 160 to 200 nm, 170 to 200 nm, 180 to 200 nm, 190 to 200 nm, 100 to 190 nm, 110 to 190 nm, 120 to 190 nm, 130 to 190 nm, 140 to 190 nm, 150 to 190 nm, 160 to 190 nm, 170 to 190 nm, 180 to 190 nm, 100 to 180 nm, 110 to 180 nm, 120 to 180 nm, 130 to 180 nm, 140 to 180 nm, 150 to 180 nm, 160 to 180 nm, 170 to 180 nm, 100 to 170 nm, 110 to 170 nm, 120 to 170 nm, 130 to 170 nm, 140 to 170 nm, 150 to 170 nm, 160 to 170 nm,100 to 160 nm, 110 to 160 nm, 120 to 160 nm, 130 to 160 nm, 140 to 160 nm, 150 to 160 nm, 100 to 150 nm, 110 to 150 nm, 120 to 150 nm, 130 to 150 nm, 140 to 150 nm, 100 to 140 nm, 110 to 140 nm, 120 to 140 nm, 130 to 140 nm, 100 to 130 nm, 110 to 130 nm, 120 to 130 nm, 100 to 120 nm, 110 to 120 nm or 100 to 110 nm.

[0057] In an embodiment, the polydispersity index (PDI) of the nanoparticles may be 0.070 to 0.180. PDI indicates the uniformity of particle size. As the PDI value approaches 0, the size of the particles in the solution is more uniform, and as it approaches 1, the size of the particles is more non-uniform. Therefore, nanoparticles can be formed with a consistent size within the above range. For example, the polydispersity index of the nanoparticles is 0.070 to 0.180, 0.080 to 0.180, 0.090 to 0.180, 0.100 to 0.180, 0.110 to 0.180, 0.120 to 0.180, 0.130 to 0.180, 0.140 to 0.180, 0.150 to 0.180, 0.160 to 0.180, 0.170 to 0.180, 0.070 to 0.170, 0.080 to 0.170, 0.090 to 0.170, 0.100 to 0.170, 0.110 to 0.170, 0.120 to 0.170, 0.130 to 0.170, 0.140 to 0.170, 0.150 to 0.170, 0.160 to 0.170, 0.070 to 0.160, 0.080 to 0.160, 0.090 to 0.160, 0.100 to 0.160, 0.110 to 0.160, 0.120 to 0.160, 0.130 to 0.160, 0.140 to 0.160, 0.150 to 0.160, 0.070 to 0.150, 0.080 to 0.150, 0.090 to 0.150, 0.100 to 0.150, 0.110 to 0.150, 0.120 to 0.150, 0.130 to 0.150, 0.140 to 0.150, 0.070 to 0.140, 0.080 to 0.140, 0.090 to 0.140, 0.100 to 0.140, 0.110 to 0.140, 0.120 to 0.140, 0.130 to 0.140, 0.070 to 0.130, 0.080 to 0.130, 0.090 to 0.130, 0.100 to 0.130, 0.110 to 0.130, 0.120 to 0.130, 0.070 to 0.120, 0.080 to 0.120, 0.090 to 0.120, 0.100 to 0.120, 0.110 to 0.120, 0.070 to 0.110, 0.080 to 0.110, 0.090 to 0.110, 0.100 to 0.110, 0.070 to 0.100, 0.080 to 0.100, 0.090 to 0.100, 0.070 to 0.090, 0.080 to 0.090 or 0.070 to 0.080 Can be.

[0058] In an embodiment, the zeta potential of the nanoparticles may be -18.00 mV or lower. As the absolute value of the zeta potential increases, a repulsive force between the particles may be exerted, thereby suppressing aggregation. Therefore, within the above range, the nanoparticles may not clump together and may remain stable for a long period of time. For example, the zeta potential of the nanoparticles may be -40.00 to -18.00 mV. For example, the zeta potential values ​​of the nanoparticles are -40.00 to -18.00 mV, -35.00 to -18.00 mV, -30.00 to -18.00 mV, -28.00 to -18.00 mV, -26.00 to -18.00 mV, -25.00 to -18.00 mV, -24.00 to -18.00 mV, -23.00 to -18.00 mV, -22.00 to -18.00 mV, -21.00 to -18.00 mV, -20.00 to -18.00 mV, -19.00 to -18.00 mV, -40.00 to -19.00 mV, -35.00 to -19.00 mV, -30.00 to -19.00 mV, -28.00 to -19.00 mV, -26.00 to -19.00 mV, -25.00 to -19.00 mV, -24.00 to -19.00 mV, -23.00 to -19.00 mV, -22.00 to -19.00 mV, -21.00 to -19.00 mV, -20.00 to -19.00 mV, -40.00 to -20.00 mV, -35.00 to -20.00 mV, -30.00 to -20.00 mV, -28.00 to -20.00 mV, -26.00 to -20.00 mV, -25.00 to -20.00 mV, -24.00 to -20.00 mV, -23.00 to -20.00 mV, -22.00 to -20.00 mV, -21.00 to -20.00 mV, -40.00 to -21.00 mV, -35.00 to -21.00 mV, -30.00 to -21.00 mV, -28.00 to -21.00 mV, -26.00 to -21.00 mV, -25.00 to -21.00 mV, -24.00 to -21.00 mV, -23.00 to -21.00 mV, -22.00 to -21.00 mV, -40.00 to -22.00 mV, -35.00 to -22.00 mV, -30.00 to -22.00 mV, -28.00 to -22.00 mV, -26.00 to -22.00 mV, -25.00 to -22.00 mV, -24.00 to -22.00 mV, -23.00 to -22.00 mV, -40.00 to -23.00 mV, -35.00 to -23.00 mV, -30.00 to -23.00 mV, -28.00 to -23.00 mV, -26.00 to -23.00 mV, -25.00 to -23.00 mV, -24.00 to -23.00 mV, -40.00 to -24.00 mV, -35.00 to -24.00 mV, -30.00 to -24.00 mV, -28.00 to -24.00 mV, -26.00 to -24.00 mV, -25.00 to -24.00 mV, -40.00 to -25.00 mV, -35.00 to -25.00 mV, -30.00 to -25.00 mV, -28.00 to -25.00 mV, It can be -26.00 to -25.00 mV, -40.00 to -26.00 mV, -35.00 to -26.00 mV, -30.00 to -26.00 mV, -28.00 to -26.00 mV, -40.00 to -27.00 mV, -35.00 to -27.00 mV, -30.00 to -27.00 mV or -28.00 to -27.00 mV.

[0059] In an embodiment, the cosmetic nanoparticle composition may include a solvent. Any known solvent may be used. For example, the solvent may include water, alcohol, glycol, mineral oil, vegetable oil, ester oil, silicone oil, ketone, and the like.

[0060] In an embodiment, the solvent may include alcohol and water.

[0061] In an embodiment, the cosmetic nanoparticle composition may further include additives commonly used in the art, as long as the effects of the embodiments of the present application are not impaired. The additives may be, for example, included in the internal matrix or included in the solvent. For example, the cosmetic composition may further include thickeners, pH adjusters, surfactants, stabilizers, preservatives, antiseptics, bactericides, moisturizers, UV blockers, skin conditioning agents, whitening agents, colorants, organic pigments, inorganic pigments, fragrances, vitamins, natural pigments, pearls, and other functional ingredients. Here, the functional ingredients may include, for example, wrinkle-improving ingredients, whitening ingredients, antioxidants, anti-aging ingredients, plumping ingredients, exfoliating ingredients, scrubbing ingredients, moisturizing ingredients, skin barrier strengthening ingredients, skin elasticity strengthening ingredients, and the like. A person skilled in the art can easily select the blending amount of the above ingredients as long as the purpose and effects of the present application are not impaired.

[0062]

[0063] According to an embodiment of the present application, a method for preparing a cosmetic nanoparticle composition is provided. The method for preparing a cosmetic nanoparticle composition may include the steps of: dissolving hyaluronic acid in water to prepare a first solution; adding alcohol to the first solution to prepare a second solution; dissolving zein and lecithin in the second solution to prepare a third solution; and adding the third solution to water. For descriptions of hyaluronic acid, zein, and lecithin, refer to those described herein.

[0064] In an embodiment, a water-poorly soluble substance may be added in at least one of the steps of preparing the first solution, preparing the second solution, or preparing the third solution. For example, in the step of preparing the first solution, the water-poorly soluble substance may be added to water. In another example, in the step of preparing the second solution, the water-poorly soluble substance may be added to the first solution, or an alcohol containing the water-poorly soluble substance may be added to the first solution. In another example, in the step of preparing the third solution, the water-poorly soluble substance may be added to the second solution. For a description of the water-poorly soluble substance, see the description herein.

[0065] In the embodiment, at the step of adding the third solution, the water may be stirred.

[0066] In the embodiment, in the step of adding the third solution, the third solution may be added slowly. For example, the third solution may be added at a rate of less than 100 mL / min. For example, the third solution may be added at a rate of 5 to 100 ml / min.

[0067]

[0068] According to an embodiment of the present application, a cosmetic composition comprising a cosmetic nanoparticle composition is provided. The cosmetic composition may comprise all of the components of the cosmetic nanoparticle composition, or may comprise only some of the components of the cosmetic nanoparticle composition. For example, the cosmetic composition may comprise all of the nanoparticles and the solvent included in the cosmetic nanoparticle composition, or may comprise only the nanoparticles. For a description of the cosmetic nanoparticle composition, see the description herein.

[0069] In an embodiment, the cosmetic composition may further include additives commonly used in the art, as long as they do not impair the effects of the embodiments of the present application. For example, the cosmetic composition may further include thickeners, pH adjusters, surfactants, stabilizers, preservatives, antiseptics, bactericides, moisturizers, sunscreens, skin conditioning agents, whitening agents, colorants, organic pigments, inorganic pigments, fragrances, vitamins, natural pigments, pearls, and other functional ingredients. Here, the functional ingredients may include, for example, wrinkle-improving ingredients, whitening ingredients, antioxidant ingredients, anti-aging ingredients, plumping ingredients, exfoliating ingredients, scrubbing ingredients, moisturizing ingredients, skin barrier strengthening ingredients, skin elasticity strengthening ingredients, and the like. A person skilled in the art can easily select the blending amount of the above ingredients as long as it does not impair the purpose and effects of the present application.

[0070] In an embodiment, the cosmetic composition may be provided in a formulation conventionally manufactured in the art. For example, the cosmetic composition may be formulated as an oil-based dispersion formulation in which a powder complex is dispersed in an oil phase, an aqueous dispersion formulation in which a powder complex is dispersed in an aqueous phase, an oil-in-water (O / W), water-in-oil (W / O), water-in-oil-in-water (W / O / W), and oil-in-water-in-oil (O / W / O) emulsion formulation, a solubilized formulation, etc. However, the present invention is not limited thereto, and the cosmetic composition may also be provided in the form of a solution, suspension, emulsion, solid, gel, oil, powder, paste, or foam aerosol.

[0071] In the embodiment, the cosmetic composition can be manufactured into various products. For example, it can be manufactured into sun care products such as sunscreen, sun stick, sun milk, sun lotion, and sun cushion. For example, it can be manufactured into functional cosmetics such as nourishing cream, essence, and ampoule, or basic cosmetics such as toner and lotion. In addition, it can be manufactured into soap, detergent, cleansing cream, and cleansing water, or color cosmetics such as lipstick, lip balm, mascara, blusher, shading, highlighter, makeup base, foundation, pact, concealer, and skin cover. It can also be manufactured into hair cleansing products such as shampoo, rinse, hair conditioner, and hair gel. Furthermore, it can be manufactured into products that are attached to the skin, such as packs, hydrogel slimming patches, and the like, or products that are sprayed onto the skin, such as mists and aerosols.

[0072] In an embodiment, the composition may be a topical skin composition. For example, the topical skin composition may have a formulation such as a solution, oil, paste, cream, gel, patch, spray, etc.

[0073] In the embodiment, the external skin composition may appropriately blend ingredients commonly used in external skin preparations such as cosmetics or pharmaceuticals, such as aqueous ingredients, oily ingredients, powder ingredients, alcohols, moisturizers, thickeners, sunscreens, whitening agents, preservatives, antioxidants, surfactants, fragrances, colorants, fatty substances, solubilizers, thickeners, gelling agents, softeners, foaming agents, air fresheners, metal ion sequestrants, chelating agents, vitamins, various skin nutrients, or combinations thereof, as needed. The blending amount of the above ingredients can be easily selected by those skilled in the art within a range that does not impair the purpose and effect of the present application.

[0074]

[0075] Hereinafter, the present invention will be described through manufacturing examples and experimental examples, but the scope of the present invention is not limited by the contents presented below.

[0076]

[0077] Manufacturing example

[0078]

[0079] (1) Manufacturing Example 1: Manufacturing of Examples 1 to 4

[0080] After dissolving hyaluronic acid in purified water, ethanol was added to the solution. At this time, the ethanol concentration was 70 wt%. Thereafter, zein and lecithin were dissolved in the prepared solution, and then added to the stirred purified water at a rate of 40 mL / min to prepare the nanoparticle compositions of Examples 1 to 4, respectively. At this time, the ratio of the added solution to the purified water was 1:3.

[0081] The contents of zein, hyaluronic acid, lecithin, ethanol, and purified water included in the nanoparticle compositions of Examples 1 to 4 that were finally manufactured are shown in Table 1. The unit of content in Table 1 is weight%.

[0082]

[0083] Distinctive agent hyaluronic acid lecithin ethanol purified water total Example 10.30.10.214 Residual amount 100 Example 20.30.10.114 Residual amount 100 Example 30.10.10.214 Residual amount 100 Example 40.30.01250.214 Residual amount 100

[0084]

[0085] (2) Manufacturing Example 2: Manufacturing of Examples 5 and 6

[0086] After dissolving hyaluronic acid in purified water, an ethanol solution containing resveratrol or ascorbyl palmitate was added to the solution. At this time, the ethanol concentration was set to 70 wt%. Thereafter, zein and lecithin were dissolved in the prepared solution, and this was then added to the stirred purified water at a rate of 40 mL / min to prepare the nanoparticle compositions of Examples 8 and 9, respectively. At this time, the ratio of the added solution to the purified water was 1:3.

[0087] The contents of zein, hyaluronic acid, lecithin, resveratrol, ascorbyl palmitate, ethanol, and purified water included in the nanoparticle compositions of the final manufactured Examples 5 and 6 are shown in Table 2. The unit of content in Table 2 is weight%.

[0088]

[0089] Distinctive agent hyaluronic acid lecithin resveratrol ascorbyl palmitate ethanol purified water total example 50.30.10.20.025-14 remaining amount 100 example 60.30.10.2-0.02514 remaining amount 100

[0090]

[0091] (3) Manufacturing Example 3: Manufacturing of Comparative Examples 1 to 17

[0092] Compositions of Comparative Examples 1 to 17 were each manufactured using the same method as Manufacturing Example 1. The contents of zein, hyaluronic acid, lecithin, ethanol, and purified water included in the final manufactured compositions of Comparative Examples 1 to 17 are shown in Table 3. The unit of content in Table 3 is weight%.

[0093]

[0094] Distinctive agent hyaluronic acid lecithin ethanol purified water total comparison example 10.3-0.01 25 14 remaining amount 100 comparison example 20.3-0.21 4 remaining amount 100 comparison example 30.30.01 25-14 remaining amount 100 comparison example 40.30.1-14 remaining amount 100 comparison example 50.30.1 25-14 remaining amount 100 comparison example 6-0.1-14 remaining amount 100 comparison example 7--0.214 remaining amount 100 comparison example 8-0.10.214 remaining amount 100 comparison example 90.050.10.214 remaining amount 100 Comparison Example 100.60.10.214 Remaining Amount 100 Comparison Example 110.80.10.214 Remaining Amount 100 Comparison Example 120.30.00010.214 Remaining Amount 100 Comparison Example 130.30.1250.012514 Remaining Amount 100 Comparison Example 140.30.10.012514 Remaining Amount 100 Comparison Example 150.30.01250.012514 Remaining Amount 100 Comparison Example 160.30.1250.3014 Remaining Amount 100 Comparison Example 170.3--14 Remaining Amount 100

[0095]

[0096] Experimental example

[0097]

[0098] (1) Experimental Example 1: Stability Evaluation

[0099] The compositions manufactured in Examples 1 to 6 and Comparative Examples 1 to 17 were visually observed to determine whether a precipitate was formed. Thereafter, the compositions were stored for one day, and then the particle size (nm), PDI, and zeta potential (mV) values ​​of the compositions were measured. The observed and measured values ​​are shown in Table 4. The particle size, PDI, and zeta potential values ​​were measured using undiluted nanoparticle solution samples at a temperature of 25 degrees using an ELSZneo device from Otsuka. The particle size and PDI values ​​were measured using the DLS (dynamic light scattering) method, and the zeta potential was measured using the ELS (electrophoretic light scattering) method.

[0100]

[0101] Separation Sediment Formation Next Day After Manufacturing Particle Size (nm) PDI Zeta Potential (mV) Example 1 X 114.0 0.151-25.63 Example 2 X 112.3 0.105-22.43 Example 3 X 132.4 0.178-25.77 Example 4 X 135.4 0.113-27.36 Example 5 X 127.6 0.102-25.44 Example 6 X 136.10.132-22.13 Comparative Example 10---Comparative Example 20---Comparative Example 30---Comparative Example 4 X 116.4 0.102-17.73 Comparative Example 5 X 152.9 0.164-20.01 Comparative Example 6 X 26 2.50. 176-16.96Comparative Example 7X362.30.226-20.69Comparative Example 8X426.40.262-35.59Comparative Example 9X109.60.22-23.49Comparative Example 10X211.80.072-21.56Comparative Example 11X302.30.003-14.79Comparative Example 12O---Comparative Example 13X150.50.166-20.43Comparative Example 14X117.50.114-21.43Comparative Example 15X143.90.079-18.76Comparative Example 16O---Comparative Example 17O---

[0102]

[0103] According to Table 4, it can be confirmed that the compositions of Examples 1 to 6 do not produce sediment, thereby stably producing nanoparticles. In particular, the compositions of Examples 1 to 6 have an appropriate particle size of 100 to 220 nm, particularly 110 to 150 nm, have a PDI of 0.070 to 0.180, particularly 0.100 to 0.180, thereby being stably dispersed, and have a zeta potential value of -18.00 mV or less, particularly -22.00 mV or less, thereby confirming excellent particle stability.

[0104] On the other hand, in the case of Comparative Examples 1 to 3, 12, 16, and 17, it was confirmed that sediments were formed and nanoparticles were not stably generated. In addition, it was confirmed that the particle sizes of Comparative Examples 5 to 8, 10, 13, and 15 were larger than those of the Examples, and it was confirmed that penetration into the skin was not easily achieved compared to the Examples. In addition, it was confirmed that the zeta potential values ​​of Comparative Examples 4 to 7, 11, 13, and 15 were larger than those of the Examples, and it was confirmed that the repulsive force between particles was insufficient compared to the Examples.

[0105] Meanwhile, in the case of Comparative Examples 9 and 14, as confirmed in the experimental examples below, it is confirmed that they have inferior effects in salt stability, particle uniformity, high-temperature stability, etc. compared to the examples.

[0106]

[0107] (2) Experimental Example 2: Salt stability evaluation

[0108] Examples 1 to 6 and Comparative Examples 4, 14 and 15 were mixed with a 0.1% NaCl (Sodium Chloride) solution in DW (purified water) (w / w) and a nanoparticle solution in a 1:1 ratio so that the final concentration of NaCl was 0.05%, and then stored for one day. The precipitate was checked to evaluate the salt stability, and the results are shown in Table 5.

[0109]

[0110] Separation Sediment Formation Salt Stability Example 1 X Good Example 2 X Good Example 3 X Good Example 4 X Good Example 5 X Good Example 6 X Good Comparative Example 4 X Bad Comparative Example 14 X Bad Comparative Example 15 X Bad

[0111]

[0112] According to Table 5, Examples 1 to 6 have excellent salt stability, but Comparative Example 4, which does not contain lecithin, and Comparative Examples 14 and 15, which contain a small amount of lecithin, have poor salt stability.

[0113]

[0114] (3) Experimental Example 3: Evaluation of particle uniformity

[0115] For Examples 1 to 4 and Comparative Examples 6, 7, and 9, particle size distributions were measured using the DLS principle using an ELSZneo device from Otsuka. Specifically, the time variation of scattering intensity due to Brownian motion of nanoparticles was evaluated using the autocorrelation function, and the particle size distribution was calculated using this. The measured particle size distribution graphs are shown in Figs. 1 and 2.

[0116] Referring to FIGS. 1 and 2, it can be confirmed that Examples 1 to 4 have a peak for only one particle size and have an even particle size distribution, and it can be confirmed that particles of an overall uniform size are formed. On the other hand, it can be confirmed that Comparative Examples 6, 7, and 9 have peaks for various particle sizes and have an irregular particle size distribution, and it can be confirmed that the particle sizes are not formed uniformly.

[0117]

[0118] (4) Experimental Example 4: High-temperature stability evaluation

[0119] After storing Examples 1 to 6 and Comparative Examples 4, 5, 10 and 13 at 50°C for 2 weeks, the particle size (nm) and PDI value of the compositions were measured and shown in Table 6. The method for measuring the particle size and PDI value is the same as in Experimental Example 1.

[0120]

[0121] Storage at 50℃ for 2 weeks Particle size (nm) PDI Example 1 289.4 0.035 Example 2 2550.131 Example 3 316.10.021 Example 4 249.30.127 Example 5 2450.019 Example 6 213.6 0.033 Comparative Example 4 4840.007 Comparative Example 5 503.80 Comparative Example 10797.8 0.371 Comparative Example 13776.10

[0122]

[0123] According to Table 6, the compositions of Examples 1 to 6 showed no significant change in particle size even when stored at 50°C for two weeks, confirming excellent high-temperature stability. On the other hand, in the case of Comparative Examples 4, 5, 10, and 13, it was confirmed that the particle size significantly increased when stored at 50°C for two weeks, confirming poor high-temperature stability.

[0124]

[0125] (5) Experimental Example 5: Evaluation of high-temperature long-term stability

[0126] After storing Examples 1, 2, Comparative Examples 4 and 14 at 50°C for one month, the particle size (nm) and PDI value of the composition were measured and shown in Table 7. The method for measuring the particle size and PDI value is the same as in Experimental Example 1.

[0127]

[0128] Storage at 50℃ for 1 month Particle size (nm) PDI Example 1 3 20.3 0.0 65 Example 2 3 13.6 0.0 3 Comparative Example 4 Sedimentation Comparative Example 14 Sedimentation

[0129]

[0130] According to Table 7, the compositions of Examples 1 and 2 showed no significant change in particle size and no sedimentation even when stored at 50°C for one month, confirming excellent high-temperature long-term stability.

[0131]

[0132] (6) Experimental Example 6: Skin irritation evaluation

[0133] The skin irritation level of Example 1 was evaluated according to the Frosch & Kligman, ICDRG (International Contact Dermatitis Research Group) and PCPC guidelines, and the results are shown in Table 8.

[0134]

[0135] Skin irritation evaluation by classification Irritation level determination Example 10.00 No irritation

[0136]

[0137] As a result of the experiment, Example 1 was evaluated to have very low skin irritation, confirming that it is suitable for use as a cosmetic.

[0138]

[0139] While specific portions of the present application have been described in detail above, it will be apparent to those skilled in the art that these specific descriptions merely represent preferred embodiments and do not limit the scope of the present application. Therefore, the substantial scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A cosmetic nanoparticle composition comprising zein, hyaluronic acid and lecithin.

2. In paragraph 1, A cosmetic nanoparticle composition, wherein the above-mentioned zein, hyaluronic acid and lecithin are contained in amounts of less than 0.6 wt%, less than 0.125 wt% and less than 0.3 wt%, respectively, relative to the total weight of the composition.

3. In paragraph 1, A cosmetic nanoparticle composition, wherein the above-mentioned zein, hyaluronic acid and lecithin are contained in amounts of 0.1 to 0.5 wt%, 0.001 to 0.12 wt% and 0.05 to 0.28 wt%, respectively, relative to the total weight of the composition.

4. In paragraph 1, The above cosmetic nanoparticle composition comprises nanoparticles including a nanoparticle film and an internal matrix, A cosmetic nanoparticle composition comprising the above nanoparticle film, the above hyaluronic acid and the above lecithin.

5. In paragraph 4, A cosmetic nanoparticle composition, wherein the inner substrate comprises a water-insoluble substance.

6. In paragraph 5, A cosmetic nanoparticle composition wherein the above-mentioned water-soluble substance has at least one of the effects of skin whitening, improving skin elasticity, improving skin wrinkles, skin regeneration, relieving skin irritation, anti-inflammation, anti-oxidation, anti-aging, antibacterial, skin moisturizing, and strengthening the skin barrier.

7. In paragraph 4, The above cosmetic nanoparticle composition further comprises a solvent, A cosmetic nanoparticle composition, wherein the solvent comprises alcohol and water.

8. In paragraph 1, A cosmetic nanoparticle composition comprising water in an amount of at least 50 wt% relative to the total weight of the composition.

9. A cosmetic composition comprising a cosmetic nanoparticle composition according to any one of claims 1 to 8.

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