Compositions comprising polypeptides for hair and methods of using the same

Abstract

Provided herein are compositions comprising a polypeptide and an excipient, wherein the polypeptide comprises a keratin or keratin associated peptide block and one or more polypeptide blocks. In some embodiments, the excipient comprises an emollient, an emulsifier, a conditioning agent, vitamin E or derivative thereof, a ceramide, a lipid nanoparticle dispersion, a hair conditioner, a skin conditioner, a cleansing agent, a detoxifying agent, or a combination thereof. Provided herein are methods for using the compositions for treating hair.

Description

WSGR Ref.63230-735.601 COMPOSITIONS COMPRISING POLYPEPTIDES FOR HAIR AND METHODS OF USING THE SAME CROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Application No.63 / 681,373, filed on August 9, 2024; U.S. Provisional Application No.63 / 681,375, filed on August 9, 2024; U.S. Provisional Application No.63 / 681,380, filed on August 9, 2024; and U.S. Provisional Application No.63 / 682,514, filed on August 13, 2024, each of which is incorporated herein by reference in its entirety. SEQUENCE LISITNG

[0002] The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled 63230-735_601_SL.xml, created August 6, 2025, which is 555,455 bytes in size. The information in the electronic format of the Sequence Listing is incorporated by reference in its entirety. SUMMARY

[0003] Formulating hair products involves navigating challenges such as achieving the right combination of ingredients for optimal performance, maintaining product stability, ensuring regulatory compliance, addressing consumer preferences for texture and scent, and balancing cost considerations. Additional complexities include preserving the product effectively, meeting environmental sustainability goals, and conducting thorough testing for safety and quality assurance as well as consumer satisfaction.

[0004] Virtually all consumers will be exposed to some level of hair damaging factors, such as environmental in the form of sun exposure, mechanical in the form of styling and combing the hair, or chemical in the form of exposing hair to chemicals (e.g., bleaches, oxidants, etc.). Typically, consumers will use leave-in products to enable these protective benefits against the various potential aggressors while also repairing hair that has already been damaged by such factors. In some instances, due to the nature of rinse off products being designed to be removed from the hair, it is not always anticipated that these products could provide the post-shower protective benefits.

[0005] Provided herein are compositions that mitigate or reverse such damage from the environment, heat, chemicals, and the like. In some instances, the compositions described herein comprise a polypeptide and an excipient. In some instances, the composition is formulated for application to hair. -1-WSGR Ref.63230-735.601

[0006] In one aspect, the present disclosure provides a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and an emollient comprising polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin / sebacic acid copolymer, C12-15 alkyl benzoate, caprylic / capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil / IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate / dicaprate, propylene glycol dicaprylate / dicaprate, triolein (algae oil), propylene glycol dicaprylate / dicaprate, phytosteryl / octyldodecyl lauroyl glutamate, phytosteryl / behenyl / octyldodecyl lauroyl glutamate, phytosteryl / decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, sclerocarya birrea seed oil, tetradecane, isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid / trimethylolpropane copolymer, pentaerythrityl stearate / caprate / caprylate / adipate, neopentyl glycol diethylhexanoate, pentaerythrityl tetraisostearate, bis-behenyl / isostearyl / phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate / caprate, coconut alkanes, C9-12 alkane, C13-15alkane, C13-16isoalkane C13-16isoparaffin, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate / caprate, castor isostearate succinate, isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, Sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, isopropyl palmitate, isopropyl palmitate, dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof, wherein the composition (i) improves cuticle smoothness, shine, or both, (ii) reduces frizz, or (iii) both (i) and (ii).

[0007] In another aspect, the present disclosure provides a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a conditioning agent comprising a protein comprising hydrolyzed -2-WSGR Ref.63230-735.601 keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof, wherein a pH of the composition is about 7 to about 8, and wherein the composition improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof.

[0008] In various aspects, the present disclosure provides a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a humectant comprising glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof, wherein a pH of the composition is about 5 to about 6, and wherein the composition improves one or more parameters of hair, wherein the parameter comprises moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof.

[0009] In some embodiments, the composition further comprises an emollient, wherein the emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof. In some embodiments, the polysorbate comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, or a combination of two or more thereof. In some embodiments, the natural oil comprises coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil, or a combination of two or more thereof. In some embodiments, the fatty alcohol comprises mystearyl alcohol, palmityl alcohol, stearyl alcohol, cetyl alcohol, cetearyl alcohol, or a combination of two or more thereof. In some embodiments, the ester comprises cetyl ester, ethylhexyl palmitate, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, methylheptyl isostearate, polyglyceryl-2-diisostearate, di-C12-15alkyl fumarate, triisostearin, myristyl myristate, palmityl palmitate, myristyl palmitate, tridecyl trimellitate, pentaerythrityl tetraethylhexanoate. In some embodiments, the ether comprises dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. In some embodiments, the emollient comprises cetearyl alcohol, dicaprylyl ether, sunflower oil, polysorbate 20, polysorbate 30, polysorbate 40, fructose, cetyl alcohol, paraffin, sorbitol, glycerin, lanolin, hyaluronic acid, mineral oil, dimethicone, castor isostearate succinate, or a combination of two or more thereof. -3-WSGR Ref.63230-735.601

[0010] In some embodiments, the composition further comprises a conditioning agent. In some embodiments, the conditioning agent increases moisture of hair, scalp, or both. In some embodiments, the conditioning agent comprises a silicone, a quaternary ammonium compound, a fatty alcohol, a natural oil, a cationic polymer, a ceramide, a polysaccharide, a protein, or a combination of two or more thereof. In some embodiments, the conditioning agent comprises a natural oil, ester, polysaccharide, protein, or a combination of two or more thereof. In some embodiments, the silicone comprises dimethicone, cyclomethicone, cyclopentasiloxane, amodimethicone, PEG-12 dimethicone, dimethiconol, phenyl trimethicone, dimethicone copolyol, stearoxy dimethicone, or behenoxy dimethicone, or a combination of two or more thereof. In some embodiments, the quaternary ammonium compound comprises cetrimonium chloride, behentrimonium chloride, or both.

[0011] In some embodiments, the composition further comprises a preservative, a pH modifier, an antioxidant, a rheology modifier, a film forming agent, or a combination thereof. In some embodiments, the preservative comprises one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof. In some embodiments, the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, or glycolic acid, or a combination thereof. In some embodiments, the antioxidant comprises a vitamin, a polyphenol, a flavonoid, a carotenoid, a fatty acid, an oil, an enzyme, or a combination thereof. In some embodiments, film forming agent comprises acrylates / C10-30 alkyl acrylate cross polymer, polyvinylpyrrolidone (PVP) / acrylates cross polymer, PVP / acrylamide cross polymer, polyacrylamidomethylpropane sulfonic acid, octylacrylamide / acrylates / butyl-aminoethyl methacrylate copolymer, vinyl caprolactam / VP / dimethylaminoethyl methacrylate copolymer, and / or polyurethane-48.

[0012] In one aspect, the present disclosure provides a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a lipid nanoparticle, wherein the lipid nanoparticle comprises: vitamin E or derivative thereof; and a ceramide, wherein the composition minimizes damage to hair and / or scalp from UV rays.

[0013] In some embodiments, the composition further comprises a lipid nanoparticle (LNP) dispersion, wherein the LNP dispersion comprises: a lipid nanoparticle; vitamin E or derivative thereof; and a ceramide.

[0014] In some embodiments, the Vitamin E or derivative thereof is present (% w / w) at 0.1% to 1% by total weight of the LNP dispersion. In some embodiments, the % by total weight of the -4-WSGR Ref.63230-735.601 LNP dispersion is a measure independent from a % by total weight of the composition. In some embodiments, the LNP dispersion is present (% w / w) at 0.01% to 5% by total weight of the composition. In some embodiments, the vitamin E or derivative thereof comprises: tocopheryl acetate, alpha-tocopherol, or a combination thereof. In some embodiments, the vitamin E or derivative thereof is present (% w / w) at 0.0005% to 0.05% by total weight of the composition.

[0015] In some embodiments, the ceramide comprises: Ceramide (Cer) 10, Cer 2, Cer 3, Cer 8, Cer 7, Cer 6, Cer 5, Cer 11, EOdS, Cer 1, Cer 9, or Cer 4, or a combination thereof. In some embodiments, the ceramide is present (%w / w) at 0.0025% to 0.1% by total weight of the composition. In some embodiments, the lipid nanoparticle is a liposome.

[0016] In some embodiments, the composition further comprises a cationic polymer. In some embodiments, the cationic polymer is associated with lipids of the lipid nanoparticle. In some embodiments, the cationic polymer comprises a polymeric quaternary ammonium compound. In some embodiments, the polymeric quaternary ammonium compound comprises polyquaternium- 4, polyquaternium-7, polyquaternium-11, polyquaternium-16, polyquaternium-22, or polyquaternium-67.

[0017] In some embodiments, the composition further comprises an oil, a preservative, or both the oil and the preservative. In some embodiments, the polypeptide is present (% w / w) at 0.001% to 1% by total weight of the composition.

[0018] In some embodiments, the composition further comprises a second solvent. In some embodiments, the second solvent is selected from a group consisting of: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate. In some embodiments, the second solvent is present (%w / w) from about 0.1% to about 20% by total weight of the composition.

[0019] In some embodiments, the composition further comprises an emulsifier. In some embodiments, the emulsifier comprises natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters. In some embodiments, the emulsifier comprises lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate / stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 -5-WSGR Ref.63230-735.601 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla / jojoba / rice bran polyglyceryl- 3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate / stearate, candelilla / jojoba / rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or polyhydroxystearic acid, or a combination thereof. In some embodiments, the emulsifier is present (w / w%) from about 1% to about 10% by total weight of the composition.

[0020] In some embodiments, the composition further comprises a conditioning agent, a humectant, an emollient, a pollution protectant, or a pH modifier.

[0021] In another aspect, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and one or more cleansing agents comprising an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof, wherein the composition removes dirt from hair, wherein the composition has a pH of about 4 to about 7. In some embodiments, the hair conditioner is present in the composition at about 0.01% (%w / w) to about 10% (%w / w).

[0022] In some embodiments, the composition further comprises a skin conditioner. In some embodiments, the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. In some embodiments, the skin conditioner is present in the composition at about 0.01% (%w / w) to about 5% (%w / w).

[0023] In some embodiments, the composition further comprises a cleansing agent. In some embodiments, the total concentration (%w / w) of the cleansing agent is about 5% (%w / w) to about 25% (%w / w).

[0024] In some embodiments, the composition further comprises a hair conditioner. In some embodiments, the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. -6-WSGR Ref.63230-735.601

[0025] In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA-dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. In some embodiments, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof.

[0026] In some embodiments, the composition further comprises an excipient, wherein the excipient comprises a humectant, a chelating agent, a buffer, a preservative, or a combination thereof. In some embodiments, the excipient is present in the composition at about 0.1% (%w / w) to about 30% (%w / w). In some embodiments, the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. In some embodiments, the humectant is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w). In some embodiments, the chelating agent comprises caprylhydroxamic acid, sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or a combination of two or more thereof. In some embodiments, the chelating agent is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w). In some embodiments, the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. In some embodiments, the buffer is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w). In some embodiments, the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. In some embodiments, the preservative is present in the composition at about 0.01% (%w / w) to about 0.1% (%w / w). In some embodiments, the composition further comprises a solvent. In some embodiments, the concentration (%w / w) of the solvent is about 50% to about 99%. In some embodiments, the pH of the composition is about 4 to about 6.

[0027] In various aspects, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a detoxifying agent comprising charcoal, bentonite, hectorite, or a combination thereof, wherein the composition removes sebum and improves one or more parameters of hair, the -7-WSGR Ref.63230-735.601 parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof.

[0028] In some embodiments, the detoxifying agent is present in the composition at about 0.01% (w / w) to about 1.0% (w / w).

[0029] In some embodiments, the composition further comprises a hair conditioner. In some embodiments, the hair conditioner is present in the composition at about 0.01% (w / w) to about 10% (w / w). In some embodiments, the hair conditioner comprises panthenol, salicylic acid, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof.

[0030] In some embodiments, the composition further comprises a skin conditioner. In some embodiments, the skin conditioner is present in the composition at about 0.01% (%w / w) to about 5% (%w / w). In some embodiments, the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof.

[0031] In some embodiments, the composition further comprises a cleansing agent. In some embodiments, the total concentration (%w / w) of the cleansing agent is about 5% to about 25%. In some embodiments, the cleansing agent is a surfactant comprising an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof. In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA-dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. In some embodiments, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof.

[0032] In some embodiments, the composition further comprises an excipient comprising a humectant, a chelating agent, a buffer, a preservative, or a combination of two or more thereof. In some embodiments, the humectant comprises glycerin, propylene glycol, propanediol, or -8-WSGR Ref.63230-735.601 isopentyldiol, or a combination of two or more thereof. In some embodiments, the humectant is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w). In some embodiments, the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. In some embodiments, the chelating agent is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w). In some embodiments, the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. In some embodiments, the buffer is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w). In some embodiments, the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. In some embodiments, the preservative is present in the composition at about 0.01% (%w / w) to about 0.1% (%w / w).

[0033] In some embodiments, the composition further comprises a solvent. In some embodiments, the concentration (%w / w) of the solvent is about 50% to about 99%.

[0034] In some embodiments, pH of the composition is about 2 to about 6.

[0035] In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 8-10, 48, 66-80, and 101-103. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 11-23, 49-55, 82-91, and 104. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 24-32, 56, 92, and 105. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 33, 57- 59, 93-95, and 106. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 34, 35, 60, 96, or 107. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 36-42, 61, or 108. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, -9-WSGR Ref.63230-735.601 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 1-7, 43-47, and 200-551. In some embodiments, the polypeptide comprises a sequence having at least about 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NO: 1 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVGR); SEQ ID NO: 2 (GGVCGPSPPCITTVPGVGVPGVGVPGVGVPGVGVPGVGVPGVG); SEQ ID NO: 3 (GGVCGPSPPCITTGAGAGSGAGAGSGAGAGSGAGAGSGAGAGS); SEQ ID NO: 4 (GGVCGPSPPCITTGGRPSDSYGAPGGGN); SEQ ID NO: 5 (GGVCGPSPPCITTGPTGPTGPAGPRGLQGLQGLQGERGEQGPT); SEQ ID NO: 6 (GGVCGPSPPCITTGGFGGMGGGSGGFGGMGGGSGGFGGMGGGS); SEQ ID NO: 7 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVG); SEQ ID NO: 78 (FCGFPSCSTSC), SEQ ID NO: 79 (CTPPSCCQLHHA). In some embodiments, the polypeptide is present in the composition at a concentration of about 0.0001% (w / w) to about 20% (w / w).

[0036] In one aspect, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying the composition described herein to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof. In another aspect, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition described herein to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. In various aspects, provided herein is a method for protecting hair of a subject, the method comprising applying the composition described herein to the hair of the subject. In some embodiments, the method further comprises lathering the hair with the composition and rinsing the hair of the subject. In one aspect, provided herein is a method for improving the protective properties of a conditioner composition, the method comprising adding an LNP dispersion to the conditioner composition to generate the composition described herein. In some embodiments, the protective property comprises protection against UV damage. In another aspect, provided herein is a method for cleansing hair, comprising using the composition described herein. In various aspects, provided herein is a method for cleansing hair, comprising using the composition described herein. -10-WSGR Ref.63230-735.601 BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Various aspects of the disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative aspects, in which the principles of the disclosure are utilized, and the accompanying drawings below.

[0038] FIG.1 shows a graph having a y-axis representing mean combing energy (Joules, J) and an x-axis representing three tested conditions: (1) Control 1 (virgin hair tresses treated with only shampoo), (2) Control 2 (bleached hair tresses treated with only shampoo), and (3) Test (bleached hair tresses treated with shampoo and a composition described herein).

[0039] FIG.2A shows a graph having a y-axis representing a mean count of broken hairs and an x-axis representing two tested conditions: (1) Control (hair tresses that were not treated and subjected to heat application), and (2) Test (damp hair tresses that were treated with a composition described herein prior to heat application). FIG.2B shows a graph having a y-axis representing a mean count of broken hairs and an x-axis representing two tested conditions: (1) Control (as in FIG.2A), and (2) Test (dried hair tresses that were treated with a composition described herein prior to heat application).

[0040] FIG.3 shows a graph having a y-axis representing a mean count of broken hairs and an x-axis representing two tested conditions: (1) Control (untreated, bleached hair tresses), and (2) Test (bleached hair tresses treated with a composition described herein).

[0041] FIG.4 shows a graph having a y-axis representing a mean count of broken hairs and an x-axis representing two tested conditions: (1) Control (untreated, bleached hair tresses), and (2) Test (bleached hair tresses treated with a first composition described herein and a second composition described herein). DETAILED DESCRIPTION

[0042] A few factors, such as environmental factors (e.g., pollution, ultraviolet rays, and the like), heat, chemicals, and the like, lead to damaged hair of a subject, which can affect the subject’s appearance and confidence. In particular, damaged hair can be characterized as hair lacking shine, dryness, decreased tensile strength, decreased break strength, decreased hydration storage capabilities, exposure of the underlying cuticle, among other properties. Further, damaged hair can be characterized as damage to keratin fibers, such as loss of disulfide bonds within keratin or between keratin and other fibers within the hair. As such, there exists a need for a composition -11-WSGR Ref.63230-735.601 capable of repairing hair. Repairing hair may include, but is not limited to, improving shine, hydration storage or moisture retention, disulfide bonds within keratin or between keratin and other fibers within the hair, tensile strength, and / or break strength.

[0043] In some instances, the compositions described herein may advantageously achieve an increase in shine, hydration storage or moisture retention, formation of disulfide bonds within keratin or between keratin and other fibers within the hair, tensile strength, and / or break strength. In some embodiments, the compositions described herein achieve one or more of these properties through the inclusion of a polypeptide with an excipient, such as an emollient, a preservative, an emulsifier, a conditioning agent, a pH modifier, an antioxidant, a film forming agent, a humectant, a fatty acid, a fatty alcohol, a rheology modifier, or a combination thereof. The composition may be formulated in various formats, such as gels, hairspray, cream, lotion, serum, and the like.

[0044] In some instances, provided herein are conditioner compositions comprising: a lipid nanoparticle comprising (e.g., encapsulating) a ceramide and vitamin E, that are useful for protecting hair from ultraviolet damage, mechanical stress damage, and / or environmental damage. Conditioner compositions generally refer to and include, but are not limited to, compositions for treating hair or skin, including scalp, face, and body, in order to provide protection to hair or skin from mechanical, chemical, and / or environmental factors that contribute to damaged or weathered hair or skin, and / or to alleviate symptoms associated with such damage. In certain instances, conditioner compositions can be distinguished from shampooing compositions by the lack of a surfactant in the conditioner composition. Conditioner compositions further refer to and the conventional understanding of a hair conditioners (leave-in and / or rinse-out), being suitable for use on humans and / or animals.

[0045] In some aspects, provided herein is a cleanser composition comprising a polypeptide and one or more cleansing agents. The polypeptide in the composition may be capable of penetrating to the cortex of the hair and improving the mechanical properties of hair.

[0046] In other aspects, provided herein is a cleanser composition comprising a polypeptide and a detoxifying agent. In some embodiments, the cleanser composition is a hair cleanser. In some embodiments, the cleanser is a scalp cleanser. In some embodiments, the cleanser composition is a hair and scalp cleanser. In some embodiments, the cleanser composition removes sebum and improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. -12-WSGR Ref.63230-735.601

[0047] The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.

[0048] Non-limiting example compositions are described in the tables and throughout the specification. Compositions

[0049] In one aspect, the present disclosure provides a composition comprising a polypeptide and an excipient. Provided herein are compositions comprising a polypeptide and an excipient, and the compositions are useful for nourishing and improving health of hair. Compositions generally refer to and include, but are not limited to, compositions for treating hair or skin, including scalp, face, and body, in order to provide protection to hair or skin from mechanical, chemical, and / or environmental factors that contribute to damaged or weathered hair or skin, and / or to alleviate symptoms associated with such damage. In certain instances, compositions can be distinguished from shampooing compositions by the lack of a surfactant in the composition. Compositions further refer to and the conventional understanding of a hair compositions (leave-in and / or rinse-out), being suitable for use on humans and / or animals. In some embodiments, provided and described herein are compositions comprising a polypeptide and an excipient.

[0050] In some aspects, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and an emollient comprising polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin / sebacic acid copolymer, C12-15 alkyl benzoate, caprylic / capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil / IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate / dicaprate, propylene glycol dicaprylate / dicaprate, triolein (algae oil), propylene glycol dicaprylate / dicaprate, phytosteryl / octyldodecyl lauroyl glutamate, phytosteryl / behenyl / octyldodecyl lauroyl glutamate, phytosteryl / decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, sclerocarya birrea seed oil, tetradecane, isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid / trimethylolpropane copolymer, -13-WSGR Ref.63230-735.601 pentaerythrityl stearate / caprate / caprylate / adipate, neopentyl glycol diethylhexanoate, pentaerythrityl tetraisostearate, bis-behenyl / isostearyl / phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate / caprate, coconut alkanes, C9-12 alkane, C13-15 alkane, C13-16 isoalkane C13-16 isoparaffin, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate / caprate, castor isostearate succinate, isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, Sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, isopropyl palmitate, isopropyl palmitate, dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. In some embodiments, the composition described herein (i) improves cuticle smoothness, shine, or both, (ii) reduces frizz, or (iii) both (i) and (ii). In some embodiments, the composition described herein further comprises a conditioning agent. In some embodiments, the composition described herein further comprises a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. In some embodiments, the composition described herein further comprises a conditioning agent, a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof.

[0051] In another aspects, provided herein is a composition comprising a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a conditioning agent comprising a protein comprising hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof. In some embodiments, provided herein is a composition comprising a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a conditioning agent comprising a protein comprising hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof, wherein a pH of the composition is about 7 to about 8, and wherein the composition improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. In some embodiments, the composition described herein further comprises an emollient. In some embodiments, the composition described herein further comprises a conditioning agent. In some embodiments, the -14-WSGR Ref.63230-735.601 composition described herein further comprises a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. In some embodiments, the composition described herein further comprises an emollient or a conditioning agent. In some embodiments, the composition described herein further comprises an emollient, a conditioning agent, a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof.

[0052] In various aspects, provided herein is a composition comprising a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a humectant comprising glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof. In some embodiments, provided herein is a composition comprising a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a humectant comprising glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof, wherein a pH of the composition is about 5 to about 6, and wherein the composition improves one or more parameters of hair, wherein the parameter comprises moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. In some embodiments, the composition described herein further comprises an emollient. In some embodiments, the composition described herein further comprises a conditioning agent. In some embodiments, the composition described herein further comprises a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. In some embodiments, the composition described herein further comprises an emollient or a conditioning agent. In some embodiments, the composition described herein further comprises an emollient, a conditioning agent, a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof.

[0053] In some embodiments, the polypeptide comprises an amino acid sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551. In some embodiments, provided and described herein are compositions comprising a polypeptide and a C10-C30hydrocarbon. In some embodiments, provided and described herein are compositions comprising a polypeptide and an emollient. In some embodiments, provided and described herein are compositions comprising a polypeptide and a C10-C30hydrocarbon, an emollient, or both.

[0054] In some embodiments, the composition comprises the formulation of Table 1. Table 1 -15-WSGR Ref.63230-735.601

[0055] In some embodiments, the composition comprises the formulation of Table 2. Table 2

[0056] In some embodiments, the composition comprises the formulation of Table 3. Table 3

[0057] In some embodiments, the solvent comprises one or more oils. In some embodiments, the composition comprises the formulation of any one of Table 4, Table 5, or Table 6. Table 4Table 5Table 6 -16-WSGR Ref.63230-735.601

[0058] In some embodiments, the composition comprises one or more oils. In some embodiments, the one or more oils comprises: sweet almond oil, argan oil, coconut oil, jojoba oil, avocado oil, grapeseed oil, sunflower oil, macadamia oil, sesame oil, or a combination thereof. In some embodiments, the composition comprises two different oils. In some embodiments, the composition comprises three different oils.

[0059] In some embodiments, the composition comprises one or more C10-C30 hydrocarbons. In some embodiments, the one or more C10-C30 hydrocarbons comprises: squalane, C13-C15 alkane, undecane, tridecane, decane, octane, octadecane, hexadecane, or a combination thereof. In some embodiments, the composition comprises two different C10-C30 hydrocarbons. In some embodiments, the composition comprises three different C10-C30 hydrocarbons. In some embodiments, the composition comprises four different C10-C30 hydrocarbons. In some embodiments, the composition comprises five different C10-C30 hydrocarbons.

[0060] In some embodiments, the composition comprises one or more emollients. In some embodiments, the emollient comprises one or more ethers, esters, or hydrocarbons. In some embodiments, the emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof.

[0061] In some embodiments, the composition comprises one or more preservatives. In some embodiments, the composition comprises two or more preservatives. In some embodiments, the composition comprises three or more preservatives. In some embodiments, the composition comprises four or more preservatives. In some embodiments, the one or more preservatives comprises caprylyl glycol, caprylhydroxamic acid, sodium benzoate, benzyl alcohol, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, and sodium benzoate. In some embodiments, the composition comprises a preservative. In some embodiments, the composition comprises a formulation of Table 7. Table 7-17-WSGR Ref.63230-735.601

[0062] In some embodiments, the composition comprises an emulsifier. In some embodiments, the emulsifier comprises fatty alcohol ethoxylates (e.g., ceteareth-20, ceteareth- 25), sorbitan esters (e.g., sorbitan oleate, sorbitan stearate), PEG esters (e.g., PEG-40 hydrogenated castor oil, PEG-100 stearate), quaternary ammonium compounds (e.g., behentrimonium chloride), polyquaternium compounds (e.g., polyquaternium-10), ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80), glyceryl esters (e.g., glyceryl stearate), cationic surfactants (e.g., cetrimonium chloride), nonionic emulsifiers (e.g., glyceryl oleate), and amphiphilic compounds (e.g., lecithin, phospholipids).

[0063] In some embodiments, the composition comprises a formulation of Table 8. Table 8

[0064] In some embodiments, the composition comprises a conditioning agent. In some embodiments, the conditioning agent comprises quaternary ammonium compounds (e.g., cetrimonium chloride, behentrimonium chloride), proteins (e.g., hydrolyzed wheat protein, hydrolyzed keratin, silk proteins), polysaccharides (e.g., hydrolyzed wheat starch, hyaluronic acid or hyaluronan (HA), heparan sulfate (HS), heparin (HP)), esters (e.g., cetyl esters, dilinoleyl esters, -18-WSGR Ref.63230-735.601 cococaprylate / caprate), silicones (e.g., dimethicone), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol), humectants (e.g., glycerin, panthenol), polyquaternium compounds (e.g., polyquaternium-7, polyquaternium-10), cationic polymers (e.g., polyquaternium-16, polyquaternium-37), ceramides, and aloe vera.

[0065] In some embodiments, the composition comprises a formulation of Table 9. Table 9

[0066] In some embodiments, provided and described herein are compositions comprising a lipid nanoparticle, wherein the lipid nanoparticle comprises: (1) vitamin E or a derivative thereof; and (2) a ceramide. In some embodiments, provided and described herein are compositions comprising a lipid nanoparticle (LNP) dispersion, wherein the lipid nanoparticle dispersion comprises: (1) a lipid nanoparticle; (2) vitamin E or a derivative thereof; and (3) a ceramide. In some embodiments, the compositions described herein are conditioner compositions.

[0067] In one aspect, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a lipid nanoparticle, wherein the lipid nanoparticle comprises vitamin E or derivative thereof; and a ceramide. In another aspect, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a lipid nanoparticle, wherein the lipid nanoparticle comprises vitamin E or derivative thereof; and a ceramide, wherein the composition minimizes damage to hair and / or scalp from UV rays.

[0068] In another aspect, disclosed herein is a composition comprising a polypeptide and a lipid nanoparticle. In some embodiments, the lipid nanoparticle further comprises a lipid nanoparticle (LNP) dispersion, wherein the LNP dispersion comprises: a lipid nanoparticle; vitamin E or derivative thereof; and a ceramide. -19-WSGR Ref.63230-735.601

[0069] Lipid nanoparticles generally refer to and include, but are not limited to, nanoscale- sized particles compose of lipids, e.g., ranging from 1 to 100 nanometers. Lipids generally refer to and include, but are not limited to, molecules comprising one or more hydrophobic moieties or groups and optionally also comprising one or more hydrophilic moieties or groups. Molecules comprising a hydrophobic portion, and a hydrophilic portion are also commonly referred to as amphiphilic molecules. Examples of amphiphilic compounds that may be included in an amphiphilic layer include, but are not limited to, phospholipids, aminolipids and sphingolipids. In an aqueous environment, the amphiphilic nature allows the molecules to self-assemble into organized structures and distinct phases (e.g., liposomes and / or vesicles). One of those phases consists of lipid bilayers, as they are present in vesicles, multilamellar / unilamellar liposomes, or membranes in an aqueous environment. Hydrophobicity can be imparted by the inclusion of non-polar groups including, but not limited to, long chain saturated and unsaturated aliphatic hydrocarbon groups and such groups substituted with one or more aromatic, alicyclic, or heterocyclic groups. Hydrophilic groups can comprise polar and / or charged groups and include carbohydrates, phosphates, carboxyl groups, sulfates, amino groups, sulfhydryls (thiols), nitro groups, hydroxyl groups, and other similar groups.

[0070] In some embodiments, the lipid nanoparticle is a liposome. In some embodiment the lipid nanoparticle is a lipid vesicle. In certain embodiments, the lipid nanoparticle has an average particle size between 100 nanometers (nm) to 900 nm. In certain embodiments, the lipid nanoparticle has an average particle size between 100 nm to 500 nm. In certain embodiments, the lipid nanoparticle has an average particle size between 100 nm to 400 nm. In certain embodiments, the lipid nanoparticle has an average particle size between 100 nm to 300 nm. In certain embodiments, the lipid nanoparticle has an average particle size between 50 nm to 350 nm. In certain embodiments, the average particle size is measured by dynamic light scattering (DLS).

[0071] In some embodiments, the nanoparticle comprises one or more lipids. In certain embodiments, the one or more lipids are selected from: phospholipids, sterols, sphingolipids, glycolipids, or a combination thereof. In certain embodiments, the nanoparticle comprises phospholipids. In certain embodiments, the phospholipids comprise: neutrally charged phospholipids, cationic phospholipids, anionic phospholipids, or a combination thereof.

[0072] In certain embodiments, the phospholipids comprise: phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phosphatidic acids, phosphatidylserines or sphingomyelin. Such phospholipids include in particular diacylphosphatidylcholines, such as distearoylphosphatidylcholine (DSPC), dioleoylphosphatidylcholine (DOPC), -20-WSGR Ref.63230-735.601 dimyristoylphosphatidylcholine (DMPC), dipentadecanoylphosphatidylcholine, dilauroyl- phosphatidylcholine, dipalmitoyl phosphatidylcholine (DPPC), diarachidoylphosphatidylcholine (DAPC), dibehenoylphosphatidylcholine (DBPC), ditricosanoylphosphatidylcholine (DTPC), dilignoceroylphosphatidylcholine (DLPC), palmitoyl-oleoyl-phosphatidylcholine (POPC), 1,2- di-O-octadecenyl-sn-glycero-3-phosphor-choline (18:0 Diether PC), 1-oleoyl-2- cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine (OChemsPC), l-hexa-decyl-sn-glycero- 3-phosphocholine (C16 Lyso PC) and phosphatidylethanolamines, in particular diacylphosphatidylethanolamines, such as dioleoylphosphatidylethanolamine (DOPE), distearoylphosphatidylethanolamine (DSPE), dipalmitoylphosphatidylethanolamine (DPPE), dimyristoylphosphatidylethanolamine (DMPE), dilauroylphosphatidylethanolamine (DLPE), diphytanoylphosphatidylethanolamine, or a combination thereof.

[0073] In some embodiments, the lipid nanoparticle comprises a mixture of lipids. In some embodiments, the mixture of lipids is obtained from lecithin. In certain embodiments, the lecithin is sourced from soybean, egg, milk, rapeseed, cottonseed, or sunflower, or a combination thereof.

[0074] Vitamin E or derivatives thereof generally refer to and include, but are not limited to, tocopherols, tocotrienols, and / or tocopheryl acetates. In some embodiments, Vitamin E or derivatives thereof comprise tocopherols, tocotrienols, and / or tocopheryl acetates. In certain embodiments, Vitamin E or derivatives thereof comprise tocopherols and / or tocopheryl acetates. In certain embodiments, the tocopherol is alpha tocopherol. In certain embodiments, the Vitamin E or derivatives thereof comprises tocopheryl acetate. In certain embodiments, the Vitamin E or derivative thereof is present at a concentration ranging from 0.0005 to 0.01% total weight of the conditioner composition. In certain embodiments, the Vitamin E or derivative thereof is present at a concentration ranging from 0.0005 to 0.005% total weight of the conditioner composition. In certain embodiments, the Vitamin E or derivative thereof is present at a concentration ranging from 0.0001 to 0.001% total weight of the conditioner composition.

[0075] In some embodiments, the Vitamin E or derivative thereof is present at 0.1 to 1% by total weight of the LNP dispersion. In some embodiments, the% by total weight of the LNP dispersion is a measure independent from a% by total weight of the composition. In some embodiments, the LNP dispersion is present at 0.01 to 5% by total weight of the composition. In some embodiments, the vitamin E or derivative thereof comprises: tocopheryl acetate, alpha- tocopherol, or a combination thereof. In some embodiments, the vitamin E or derivative thereof is present at 0.0005 to 0.05% by total weight of the composition. -21-WSGR Ref.63230-735.601

[0076] Ceramides generally refer to and include, but are not limited to, lipids chemically composed of a sphingoid base—a long-chain amino alcohol (long-chain base, e.g., C18-20)— and a fatty acid (e.g., C16-36) joined by an amide bond. In some embodiments, the sphingoid base comprises dihydrosphingosine (dS), sphingosine (S), phytosphingosine (P) or 6-hydroxy sphingosine (H). In some embodiments, the sphingoid base generally consists of dihydrosphingosine (dS), sphingosine (S), phytosphingosine (P) or 6-hydroxy sphingosine (H). The fatty acid may be a non-hydroxyl FA (N), an α-hydroxyl FA (A), or an esterified ω-hydroxyl FA (EO). In certain embodiments, the ceramide comprises: Cer 10, Cer 2, Cer 3, Cer 8, Cer 7, Cer 6, Cer 5, Cer 11, EOdS, Cer 1, Cer 9, or Cer 4. In certain embodiments, the ceramide comprises Cer 10. In certain embodiments, the ceramide comprises Cer 2. In certain embodiments, the ceramide comprises Cer 3. In certain embodiments, the ceramide comprises Cer 8. In certain embodiments, the ceramide comprises Cer 7. In certain embodiments, the ceramide comprises Cer 6. In certain embodiments, the ceramide comprises Cer 5. In certain embodiments, the ceramide comprises Cer 11. In certain embodiments, the ceramide comprises EOdS. In certain embodiments, the ceramide comprises Cer 1. In certain embodiments, the ceramide comprises Cer 9. In certain embodiments, the ceramide comprises Cer 4. In certain embodiments, the ceramide is Cer 10. In certain embodiments, the ceramide is Cer 2. In certain embodiments, the ceramide is Cer 3. In certain embodiments, the ceramide is Cer 8. In certain embodiments, the ceramide is Cer 7. In certain embodiments, the ceramide is Cer 6. In certain embodiments, the ceramide is Cer 5. In certain embodiments, the ceramide is Cer 11. In certain embodiments, the ceramide is EOdS. In certain embodiments, the ceramide is Cer 1. In certain embodiments, the ceramide is Cer 9. In certain embodiments, the ceramide is Cer 4.

[0077] In some embodiments, the ceramide is present (% w / w) at 0.0025% to 0.05% by total weight of the composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.0005% to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.001% to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.0025% to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.0025% to 0.0075% total weight of the conditioner composition.

[0078] In some embodiments, the conditioner composition comprises the formulation of Table 57 or Table 58. -22-WSGR Ref.63230-735.601 Table 57Table 58

[0079] Lipid nanoparticle dispersions (LNP dispersions) generally refer to and include, but are not limited to, colloidal mixtures comprising lipid nanoparticles (e.g., liposomes). In some embodiments, the lipid nanoparticle is a liposome. In some embodiments, the conditioner composition comprises the formulation of Table 59, wherein the LNP dispersion comprises one or more phospholipids, vitamin E, ceramide, or a combination thereof, each of which are present in an amount expressed as a mass percent (w / w%) of a total weight of the LNP dispersion before the LNP dispersion is included in the conditioner composition. Table 5960, wherein the LNP dispersion comprises one or more phospholipids, vitamin E, ceramide, or a combination thereof, each of which are present in an amount expressed as a mass percent (w / w%) -23-WSGR Ref.63230-735.601 of a total weight of the LNP dispersion before the LNP dispersion is included in the conditioner composition. Table 60

[0081] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a cationic polymer. In some embodiments, the composition comprises a LNP dispersion. In some embodiments, the LNP dispersion further comprises a cationic polymer. In some embodiments, the cationic polymer is associated with the lipids (e.g., phospholipids) forming the liposome. In some embodiments, the cationic polymer is associated with lipids of the lipid nanoparticle. In certain embodiments, the LNP dispersion comprises the formulation of Table 61 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 61

[0082] In certain embodiments LNP dispersion comprises the formulation of Table 62 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 62-24-WSGR Ref.63230-735.601

[0083] In certain embodiments, the cationic polymer is a polymeric quaternary ammonium compound. In certain embodiments, the polymeric quaternary ammonium compound is polyquaternium-4, polyquaternium-7, polyquaternium-11, polyquaternium-16, polyquaternium- 22, or polyquaternium-67. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-7. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-11. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-22. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-67. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-4.

[0084] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an oil, a preservative, or both the oil and the preservative.

[0085] In some embodiments, the lipid nanoparticle (e.g., liposome or vesicle) comprises one or more oils. In certain embodiments, the one or more oils comprise: sweet almond oil, argan oil, coconut oil, jojoba oil, jojoba seed oil, avocado oil, grapeseed oil, macadamia oil, sesame oil, or a combination thereof. In some embodiments, the lipid nanoparticle (e.g., liposome or vesicle) comprises two different oils.

[0086] In certain embodiments LNP dispersion comprises the formulation of Table 63 or Table 64 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 63Table 64 %by total weight of LNP Dispersion-25-WSGR Ref.63230-735.601preservative. In certain embodiments LNP dispersion comprises the formulation of Table 9 (e.g., before addition of the LNP dispersion to the conditioner composition). In certain embodiments, the preservative is phenoxyethanol. Table 65

[0088] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent such as water. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises another solvent in addition to water.

[0089] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an emulsifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent and an emulsifier.

[0090] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a conditioning agent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or a conditioning agent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a humectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or a humectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further -26-WSGR Ref.63230-735.601 comprises an emollient. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or an emollient. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a pollution protectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or a pollution protectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a pH modifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or a pH modifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a conditioning agent, a humectant, an emollient, a pollution protectant, or a pH modifier.

[0091] In some aspects, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551. In some embodiments, the composition further comprises one or more cleansing agents. In some embodiments, the composition comprises three or more cleansing agents. In some embodiments, the composition comprises four or more cleansing agents. In some embodiments, the composition comprises five or more cleansing agents. In some embodiments, the composition comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2- sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium C14- 16 alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucosides hydroxypropylsulfonate, disodium laurylglucosides hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside cross polymer, dioctyl sodium sulfosuccinate, or any combinations thereof. In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, -27-WSGR Ref.63230-735.601 sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. In some embodiments, the cleansing agent comprises an amphoteric surfactant. In some embodiments, the cleansing agent is an amphoteric surfactant. Non-limiting example of an amphoteric surfactant includes cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, or a combination of two or more thereof. In some embodiment, the composition comprises a polypeptide comprising a sequence comprising at least 80% sequence identity to any one SEQ ID NOs: 1-511 and a hair conditioner comprising panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. In some embodiments, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a hair conditioner comprising panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof, wherein the composition removes dirt from hair, wherein the composition has a pH of about 4 to about 7. In some embodiments, the composition described herein is a cleanser. In some embodiments, a cleanser comprises a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a hair conditioner.

[0092] In some embodiments, a composition described herein comprises a polypeptide and a hair conditioner. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, and a skin conditioner. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, and a cleansing agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, and a cleansing agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, and an excipient or an additional -28-WSGR Ref.63230-735.601 agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a cleansing agent, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient or an additional agent.

[0093] In some embodiments, the composition described herein is a cleanser. In some embodiments, the cleanser comprises a hair conditioner; a hair conditioner and a cleansing agent; a hair conditioner and a skin conditioner; a skin conditioner and a cleansing agent; or a hair conditioner, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a hair conditioner and at least one of: a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a skin conditioner, and at least one of: a hair conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a cleansing agent, and at least one of: a hair conditioner; a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a cosmetically or dermatologically acceptable excipient, and at least one of: a hair conditioner, a skin conditioner, or a cleansing agent. In some embodiments, the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, a cosmetically or dermatologically acceptable excipient, or a combination of two or more thereof. In some embodiments, the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient.

[0094] In some embodiments, the cleansers described herein provide a long-lasting improved texture and improved manageability to the hair when dried. After prolonged use, the cleansers described herein may provide the hair with soft, shiny, undamaged texture and with the other desired features. The cleansers described herein may not strip the hair of any essential oils, mitigates protein loss, and repairs the underlying hair damage, thus avoiding excess reliance on conditioners that coat the hair fiber to achieve desired properties. Further, due to their limited ingredients, the cleansers described herein do not contribute to the build-up of excess conditioning agents or other products that can ultimately weigh hair down.

[0095] In some embodiment, the cleanser provided herein comprise a solvent, a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the composition described herein provides improved resistance, strength, toughness, and elasticity to the hair.

[0096] In some embodiments, the cleanser described herein cleans the hair while maintaining an optimum pH environment of hair to minimize fiber swelling and preserve -29-WSGR Ref.63230-735.601 structural integrity. Additionally, the cleansers may clean the scalp while maintaining an optimum pH environment to avoid over drying the scalp and without disrupting the natural barrier function of the scalp. The cleansers described herein may have a pH optimized to cleanse the hair and scalp. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of certain ingredients in the cleanser. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of salicylic acid. In some embodiments, the pH of the cleanser is optimized to promote chelation of certain minerals and metals. In some embodiments, the pH of the cleanser is optimized to minimize swelling of the cuticle. In some embodiments, reduced swelling of the cuticle reduces tangling of the hair. In some embodiments, the pH of the cleanser is optimized to protect the structural integrity of the hair and mitigate protein and lipid loss.

[0097] In some embodiments, the cleanser described herein enriches and improves the properties and characteristics of the hair, such as elasticity, strength, pH, structural integrity, appearance, and feel, repairing and / or preserving damaged keratinous fiber or any combination of two or more thereof. In some embodiments, the cleanser described herein increases resistance due to the presence of the cysteine-rich peptides, even after rinsing the hair several times with water. In some embodiments, the cleanser described herein acts as an effective cleanser without the associated harshness of other compositions in the art, at a hair-appropriate pH, and without excessive use of conditioning agents. In some embodiments, in the context of the present disclosure, the cleanser can also be applied to the hair as, but not limited to, an aqueous solution or conventional shampoo or conditioner.

[0098] In various aspects, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a detoxifying agent. In some embodiments, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a detoxifying agent comprising charcoal, bentonite, hectorite, or a combination thereof. In some embodiments, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a detoxifying agent comprising charcoal, bentonite, hectorite, or a combination thereof, wherein the composition removes sebum and improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof.

[0099] In some embodiments, the composition—comprising a polypeptide and a detoxifying agent—is a cleanser or a cleanser composition. In some embodiments, the cleanser described herein provides a long-lasting improved texture and improved manageability to the hair when -30-WSGR Ref.63230-735.601 dried. After prolonged use, the cleansers described herein provide the hair with soft, shiny, undamaged texture and with the other desired features. The cleansers described herein do not strip the hair of any essential oils, mitigates protein loss, and repairs the underlying hair damage, thus avoiding excess reliance on conditioners that coat the hair fiber to achieve desired properties. Further, due to their limited ingredients, the cleansers described herein do not contribute to the build-up of excess conditioning agents or other products that can ultimately weigh hair down. Polypeptides

[0100] Keratin proteins may be lost when washed with a standard shampoo. Further, the pH of the hair during the washing may further contribute to protein loss due to swelling of the hair cuticle. The present application describes a composition that comprises a polypeptide, which can be based on the structure of keratin and keratin associated proteins. The polypeptides (also referred to as peptides) described herein may bind hair with high affinity and repair keratinous fiber damage through the formation of disulfide bonds. The polypeptides may have a sequence containing one or more cysteine amino acids that form one or more disulfide bonds with free cysteine amino acids in the hair or keratins as well as participate in other types of bonding interactions that stabilize native hair proteins. The formation of new peptide-protein bonds may help to restore the mechanical properties of the hair fiber including elasticity, resistance, and appearance, among other properties.

[0101] In some embodiments, the polypeptide comprises a polypeptide sequence of Table 10. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identity to any one of or any combination of a polypeptide sequence of Table 10. In some embodiments, the polypeptide consists of a peptide sequence of Table 10. In some embodiments, the polypeptide consists of a polypeptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of or any combination of a peptide sequence of Table 10. In some embodiments, the polypeptide comprises a peptide sequence comprising any one of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93- 95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, -31-WSGR Ref.63230-735.601 or 100% identical to any one of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the polypeptide consists of a peptide sequence of any one of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the polypeptide consists of a peptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof.

[0102] In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 8-10, 48, 66-80, and 101-103. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 11-23, 49-55, 82-91, and 104. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 24-32, 56, 92, and 105. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 33, 57- 59, 93-95, and 106. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 34, 35, 60, 96, or 107. In some -32-WSGR Ref.63230-735.601 embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 36-42, 61, or 108. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 1-7, 43-47, and 200-551. Table 10. Non-limiting example of peptide sequences-33-WSGR Ref.63230-735.601-34-WSGR Ref.63230-735.601-35-WSGR Ref.63230-735.601-36-WSGR Ref.63230-735.601-37-WSGR Ref.63230-735.601-38-WSGR Ref.63230-735.601

[0103] In some embodiments, the polypeptide comprises a peptide sequence (e.g., a fusion peptide) of Table 11. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identity to any one of or any combination of a peptide sequence of Table 11. In some embodiments, the polypeptide consists of a peptide sequence of Table 11. In some embodiments, the polypeptide -39-WSGR Ref.63230-735.601 consists of a peptide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical of any one of or any combination of a peptide sequence of Table 11. In some embodiments, the polypeptide comprises a peptide sequence comprising any one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316-374, SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identity to any one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316- 374, SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. In some embodiments, the polypeptide consists of a peptide sequence of any one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316-374, SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. In some embodiments, the polypeptide consists of a peptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identity to any one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316-374, SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof.

[0104] In some embodiments, the polypeptide comprises a sequence having at least about 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NO: 1 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVGR); SEQ ID NO: 2 (GGVCGPSPPCITTVPGVGVPGVGVPGVGVPGVGVPGVGVPGVG); SEQ ID NO: 3 (GGVCGPSPPCITTGAGAGSGAGAGSGAGAGSGAGAGSGAGAGS); SEQ ID NO: 4 (GGVCGPSPPCITTGGRPSDSYGAPGGGN); SEQ ID NO: 5 (GGVCGPSPPCITTGPTGPTGPAGPRGLQGLQGLQGERGEQGPT); SEQ ID NO: 6 (GGVCGPSPPCITTGGFGGMGGGSGGFGGMGGGSGGFGGMGGGS); SEQ ID NO: 7 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVG); SEQ ID NO: 78 (FCGFPSCSTSC), SEQ ID NO: 79 (CTPPSCCQLHHA) Table 11. Non-limiting example of fusion peptide sequences -40-WSGR Ref.63230-735.601-41-WSGR Ref.63230-735.601-42-WSGR Ref.63230-735.601-43-WSGR Ref.63230-735.601-44-WSGR Ref.63230-735.601-45-WSGR Ref.63230-735.601-46-WSGR Ref.63230-735.601-47-WSGR Ref.63230-735.601-48-WSGR Ref.63230-735.601-49-WSGR Ref.63230-735.601-50-WSGR Ref.63230-735.601-51-WSGR Ref.63230-735.601-52-WSGR Ref.63230-735.601-53-WSGR Ref.63230-735.601

[0105] In some embodiments, provided and described herein are compositions comprising polypeptides. When hair experiences stress from environmental factors (e.g., pollution, ultraviolet rays, oxidation resulting in breakage of disulfide bonds holding keratin together. The administration of the polypeptides herein to hair, such as damaged hair, enable repair of keratin and hair. In some embodiments, the polypeptides described herein bind hair with high affinity and repair keratinous fiber damage through the formation of disulfide bonds. The polypeptides have a sequence containing one or more cysteine amino acids that form disulfide bonds with free cysteine amino acids in the hair or keratins as well as participate in other types of bonding interactions that stabilize native hair proteins. The formation of new peptide-protein bonds helps to restore the mechanical properties of the hair fiber including elasticity, resistance, and appearance. In some embodiments, the polypeptide in the composition is selected from SEQ ID NOs: 1-551.

[0106] In some embodiments, the polypeptide comprises a peptide sequence of one of SEQ ID NOs: 1-551. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of any one of or any combination of one of SEQ ID NOs: 1-551. In some embodiments, the polypeptide consists of a peptide of SEQ ID NOs: 1-551.

[0107] In some embodiments, the polypeptide comprises a peptide sequence of Table 10 or Table 11. In some embodiments, the peptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of any one of or any combination of a peptide sequence of Table 10 or Table 11. In some embodiments, the peptide consists of a peptide sequence of Table 10 or Table 11. In some embodiments, the peptide consists of a peptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of any one of or any combination of a peptide sequence of Table 10 or Table 11. In some embodiments, the peptide comprises a peptide sequence comprising SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: -54-WSGR Ref.63230-735.601 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the peptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the peptide consists a peptide sequence of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the peptide consists a peptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67- 80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61.

[0108] The concentration of the polypeptide to be used depends on several factors, such as the condition of the hair, the origin of the hair, and the hair treatment composition. The polypeptide described herein can be prepared by conventional methods of peptide synthesis. In some embodiments, the polypeptide is present in the composition at a concentration of about 0.0001% (w / w) to about 20% (w / w). In some embodiments, the polypeptide is present in the composition at a concentration (% w / w) from about 0.0001% to about 20%, from about 0.001% to about 20%, from about 0.001% to about 15%, from about 0.001% to about 10%, from about 0.001% to about 5%, from about 0.001% to about 2%, from about 0.001% to about 1%, from about 0.01% to about 20%, from about 0.01% to about 15%, from about 0.01% to about 10%, from about 0.01% to about 5%, from about 0.01% to about 2%, from about 0.0001% to about 1.0%, from about 0.01% to about 1%, from about 0.05% to about 20%, from about 0.05% to about -55-WSGR Ref.63230-735.601 15%, from about 0.05% to about 10%, from about 0.05% to about 5%, from about 0.05% to about 2%, or from about 0.05% to about 1% of a total weight of the composition.

[0109] In some embodiments, the polypeptide is present at 0.001% to 1% by total weight of the composition. In some embodiments, the concentration (%w / w) of the polypeptide in the composition is about 0.0001% to about 1.0%. In some embodiments, the concentration of the polypeptide in the composition is about 0.0001%, about 0.0005%, about 0.0010%, about 0.0015%, about 0.0020%, about 0.0025%, about 0.0030%, about 0.0035%, about 0.0040%, about 0.0045%, about 0.0050%, about 0.0055%, about 0.0060%, about 0.0065%, about 0.0070%, about 0.0075%, about 0.0080%, about 0.0085%, about 0.0090%, about 0.0095%, about 0.01%, about 0.05%, about 0.055%, about 0.060%, about 0.065%, about 0.070%, about 0.075%, about 0.080%, about 0.085%, about 0.090%, about 0.095%, about 0.1%, about 0.15%, about 020%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, about 2.0%, and any values there between. In some embodiments, the concentration of the polypeptide in the composition is about 0.0001% to about 0.95%, about 0.0005% to about 0.9%, about 0.001% to about 0.85%, about 0.005% to about 0.8%, about 0.010% to about 0.75%, about 0.050% to about 0.70%, about 0.10% to about 0.65%, about 0.15% to about 0.60%, about 0.20% to about 0.55%, about 0.25% to about 0.50%, about 0.30% to about 0.45%, about 0.35% to about 0.40%, and about 0.40% to about 1.0%.

[0110] In some embodiments, the composition comprises the formulation of any one of Tables 1-9. In some embodiments, the composition comprises the formulation of Table 1. In some embodiments, the composition comprises the formulation of Table 2. In some embodiments, the composition comprises the formulation of Table 3. In some embodiments, the composition comprises the formulation of Table 4. In some embodiments, the composition comprises the formulation of Table 5. In some embodiments, the composition comprises the formulation of Table 6. In some embodiments, the composition comprises the formulation of Table 7. In some embodiments, the composition comprises the formulation of Table 8. In some embodiments, the composition comprises the formulation of Table 9.

[0111] In certain embodiments, the composition comprises the formulation of Table 66 or Table 67. In certain embodiments, the composition comprises the formulation of Table 68 or Table 69. In some embodiments, the composition comprising the formulation of Table 66, Table -56-WSGR Ref.63230-735.601 67, Table 68, or Table 69 are a conditioner composition. In some embodiments, the composition comprises the formulation of Table 119. Table 66Table 67Table 68Table 69

[0112] In some embodiments, the polypeptide provides improved resistance, strength, toughness, elasticity, or a combination thereof to the hair or scalp. Solvents

[0113] In some embodiments, the composition described herein comprises a solvent. In some embodiments, the composition comprising a polypeptide and a hair conditioner further -57-WSGR Ref.63230-735.601 comprises a solvent. In some embodiments, the composition comprising a polypeptide and a detoxifying agent further comprises a solvent. In some embodiments, the composition comprising a polypeptide, a hair conditioner, and a detoxifying agent further comprises a solvent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent such as water. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises another solvent in addition to water.

[0114] Solvents generally refer to and include, but are not limited to, substances used to dissolve or disperse other ingredients in the formulation, contributing to the product's overall consistency, stability, and performance. Solvents can also include, but are not limited to, substances that dissolve solutes. Examples of solvents in the compositions herein include but are not limited to water, alcohols (e.g., ethanol, isopropyl alcohol, denatured alcohol), glycols (e.g., propylene glycol, butylene glycol), silicones (e.g., dimethicone), esters (e.g., isopropyl palmitate, isopropyl myristate), and emollients (e.g., oils, fatty alcohols). In some embodiments, the composition comprises one or more solvents selected from water, alcohols (e.g., ethanol, isopropyl alcohol denatured alcohol l), glycols (e.g., propylene glycol, butylene glycol), silicones (e.g., dimethicone), esters (e.g., isopropyl palmitate, isopropyl myristate), and oils (e.g., olive coconut oil, argan oil, jojoba oil). In some embodiments, the solvent comprises water. In some embodiments, the solvent is water. In some embodiments, the solvent comprises water, alcohols (e.g., ethanol, isopropyl alcohol, denatured alcohol), or glycols (e.g., propylene glycol, butylene glycol).

[0115] In certain embodiments, the conditioner composition comprises one or more solvents selected from water, alcohols (e.g., ethanol, isopropyl alcohol), glycols (e.g., propylene glycol, butylene glycol), silicones (e.g., dimethicone), esters (e.g., isopropyl palmitate, isopropyl myristate), and emollients (e.g., oils, fatty alcohols).

[0116] In some embodiments, the composition comprises a solvent. In some embodiments, the composition comprises one or more solvents. In some embodiments, the solvent is water. In addition to water, in some embodiments, the composition comprises a solvent comprising ethanol, isopropanol, butanol, denatured alcohol, dimethyl isosorbide, chlorotrifluoropropene, propylene glycol, ethylene glycol, butylene glycol, propanediol, or triethyl citrate. In some embodiments, the solvent comprises alcohols. In some embodiments, the alcohol comprises one or more of ethanol, isopropanol, butanol, or a combination thereof. In some embodiments, the solvent comprises dimethyl isosorbide. In some embodiments, the solvent comprises -58-WSGR Ref.63230-735.601 chlorotrifluoropropene. In some embodiments, the solvent comprises glycols. In some embodiments, the glycol comprises propylene glycol, ethylene glycol, butylene glycol, or a combination thereof. In some embodiments, the solvent comprises triethyl citrate. In some embodiments, the solvent comprises an oil. In some embodiments, the solvent comprises one or more oils. In some embodiments the solvent is one or more oils. In some embodiments, the one or more oils comprises avocado oil, sunflower oil, sunflower seed oil, coconut oil, argan oil, jojoba oil, olive oil, castor oil, or a combination of two or more thereof. In some embodiments, the one or more oils comprises avocado oil and one or more of sunflower oil, sunflower seed oil, coconut oil, argan oil, jojoba oil, olive oil, castor oil, or a combination of two or more thereof. In some embodiments, the one or more oils comprises coconut oil and one or more of avocado oil, sunflower oil, sunflower seed oil, argan oil, jojoba oil, olive oil, castor oil, or a combination of two or more thereof. In some embodiments, the one or more oils comprises jojoba oil and one or more of avocado oil, sunflower oil, sunflower seed oil, coconut oil, argan oil, olive oil, castor oil, or a combination of two or more thereof.

[0117] In addition to water, in some embodiments, the conditioner composition comprises a solvent selected from: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate. In certain embodiments, the solvent comprises alcohols. In certain embodiments, the solvent comprises dimethyl isosorbide. In certain embodiments, the solvent comprises chlorotrifluoropropene. In certain embodiments, the solvent comprises glycols. In certain embodiments, the solvent comprises triethyl citrate.

[0118] In some embodiments, the solvent comprises water and one or more of ethanol, isopropanol, butanol, denatured alcohol, dimethyl isosorbide, chlorotrifluoropropene, propylene glycol, ethylene glycol, butylene glycol, propanediol, or triethyl citrate, or a combination thereof. In some embodiments, the solvent comprises water and two or more of ethanol, isopropanol, butanol, denatured alcohol, dimethyl isosorbide, chlorotrifluoropropene, propylene glycol, ethylene glycol, butylene glycol, propanediol, or triethyl citrate, or a combination thereof. In some embodiments, the solvent comprises water and three or more of ethanol, isopropanol, butanol, denatured alcohol, dimethyl isosorbide, chlorotrifluoropropene, propylene glycol, ethylene glycol, butylene glycol, propanediol, or triethyl citrate, or a combination thereof.

[0119] In some embodiments, the solvent is present to suspend or dissolve ingredients in the compositions. In some embodiments, the solvent is present up to 85% (w / w) of a total weight of the composition. In some embodiments, the solvent is present up to 80% (w / w) of a total weight of the composition. In some embodiments, the solvent is present up to 75% (w / w) of a total -59-WSGR Ref.63230-735.601 weight of the composition. In some embodiments, the solvent is present up to 70% (w / w) of a total weight of the composition. In some embodiments, the solvent is present up to 65% (w / w) of a total weight of the composition. In some embodiments, the solvent is present up to 60% (w / w) of a total weight of the composition. In some embodiments, the solvent is present up to 55% (w / w) of a total weight of the composition. In some embodiments, the solvent is present up to 50% (w / w) of a total weight of the composition. In some embodiments, the solvent is present up to 45% (w / w) of a total weight of the composition. In some embodiments, the solvent is present up to 40% (w / w) of a total weight of the composition.

[0120] In some embodiments, the composition comprises one or more solvents. IN some embodiments, the solvent is present to suspend or dissolve the polypeptide in the composition. In some embodiments, each solvent is present up to 0.1% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 0.5% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 1% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 2.5% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 5% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 7.5% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 10% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 12.5% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 15% (w / w) total weight of a composition. In some embodiments, each solvent is present up to 20% (w / w) total weight of a composition.

[0121] In some embodiments, a composition comprising a polypeptide, and a lipid nanoparticle further comprises a first solvent. In some embodiments, a composition comprising a polypeptide, and a lipid nanoparticle further comprises a second solvent. In some embodiments, the second solvent comprises a non-water solvent comprising alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate, or a combination thereof. In some embodiments, the non-water solvent is selected from a group consisting of alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate.

[0122] In some embodiments, the non-water solvent is present (% w / w) from about 0.01% to about 25% or from about 0.1% to about 20% by total weight of a composition. In some embodiments, the non-water solvent is present (% w / w) from 0.1% to 20% total weight of a composition. In certain embodiments, the non-water solvent is present (% w / w) from 0.5% to 10% total weight of a composition. In certain embodiments, the solvent other than water is present from 1% to 10% total weight of a composition. In certain embodiments, the solvent other than water is present (% w / w) from 2% to 8% total weight of a composition. -60-WSGR Ref.63230-735.601

[0123] In some embodiments, the composition comprises the formulation of Tables 1-9.

[0124] In certain embodiments, the conditioner composition comprises the formulation of Table 70. In certain embodiments, the conditioner composition comprises the formulation of Table 71 or Table 72. Table 70Table 71Table 72composition described herein comprises a polypeptide, a hair conditioner, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a cleansing agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and a solvent. In some embodiments, the composition -61-WSGR Ref.63230-735.601 described herein comprises a polypeptide, a hair conditioner, a skin conditioner, an excipient or an additional agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a cleansing agent, an excipient or an additional agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, an excipient or an additional agent, and a solvent.

[0126] In some embodiments, a composition is a cleanser. In some embodiments, a composition described herein comprises a polypeptide, a detoxifying agent, and a solvent. In some embodiments, a composition is a cleanser. In some embodiments, a composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a cleansing agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, an excipient or an additional agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a cleansing agent, an excipient or an additional agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, an excipient or an additional agent, and a solvent.

[0127] In some embodiments, the cleanser comprises a solvent. In some embodiments, the composition described herein further comprises a solvent. In some embodiments, the solvent comprises water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, lower alcohols containing from 1 to 6 carbon atoms, such as ethanol; polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose; or any combinations thereof.

[0128] In some embodiments, the total concentration (%w / w) of the solvent in the cleanser is about 50% to about 99%. In some embodiments, the concentration (%w / w) of the solvent in a cleanser comprising one skin condition is about 50% to about 99%. In some embodiments, the concentration of each solvent in a cleanser comprising two or more solvent is at about 50% to about 99%. In some embodiments, the concentration (%w / w) of the solvent in the cleanser is -62-WSGR Ref.63230-735.601 about 50% to about 99%. In some embodiments, the concentration of the solvent in the cleanser is about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 99% and any values therebetween. In some embodiments, the concentration of the solvent in the cleanser is about 50% to about 90%, about 55% to about 85%, about 60% to about 80%, about 65% to about 80%, and about 70% to about 80%. In some embodiments, the concentration of the solvent can vary (e.g., variable) depending on the concentration of other components of the cleanser. In some embodiments, the concentration of the solvent, when combined with the concentration of other components of the cleanser, yields 100% (%w / w).

[0129] In some embodiments, the concentration (%w / w) of the solvent in a cleanser is about 50% to about 99%, about 60% to about 95%, about 65% to about 95%, about 70% to about 95%, or about 75% to about 95%. Emollients

[0130] In some embodiments, the composition described herein comprise an emollient. In some embodiments, the composition described herein further comprises an emollient. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an emollient. In some embodiments, a conditioner composition comprises an emollient.

[0131] Emollients generally refer to and include, but are not limited to, ingredients that impart a smooth and soft texture to the hair (e.g., by preventing moisture loss and enhancing the flexibility of the hair shaft). In certain instances, emollients form a protective film on the hair surface, making it more manageable, reducing frizz, and improving overall texture. Examples include but are not limited to polysorbates (e.g., polysorbate 20, polysorbate 30, polysorbate 40), hydrocarbons (e.g., C9-12 alkane, C13-15 alkane, C13-16 isoalkane, squalane, undecane, tridecane, decane), natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), ethers (e.g., dicaprylyl ether, didecylyl ether, dilauryl ether), and esters (e.g., isopropyl palmitate, isopropyl myristate, castor isostearate succinate). Additional examples include but are not limited to natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), and synthetic esters (e.g., isopropyl palmitate, isopropyl myristate).

[0132] In some embodiments, the composition comprises an emollient. In some embodiments, the composition comprises one or more emollients. In some embodiments, the -63-WSGR Ref.63230-735.601 emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof. In some embodiments, the composition comprises one or more emollients selected from polysorbates (e.g., polysorbate 20, polysorbate 30, polysorbate 40), natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), ethers (e.g., dicaprylyl ether, didecylyl ether, dilauryl ether), and esters (e.g., isopropyl palmitate, isopropyl myristate, castor isostearate succinate). In some embodiments, the emollients comprise polysorbates (e.g., polysorbate 20, polysorbate 30, polysorbate 40), natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), ethers (e.g., dicaprylyl ether, didecylyl ether, dilauryl ether), esters (e.g., isopropyl palmitate, isopropyl myristate, castor isostearate succinate), or combinations of two or more thereof. In some embodiments, the emollients comprise cetyl alcohol, stearyl alcohol, cetearyl alcohol, dicaprylyl ether, didecylyl ether, dilauryl ether, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, or combinations of two or more thereof. In some embodiments, the emollients comprise polysorbates (e.g., polysorbate 20, polysorbate 30, polysorbate 40), hydrocarbons (e.g., C9-12 alkane, C13-15 alkane, C13-16 isoalkane, squalane, undecane, tridecane, decane), natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), ethers (e.g., dicaprylyl ether, didecylyl ether, dilauryl ether), esters (e.g., isopropyl palmitate, isopropyl myristate, castor isostearate succinate), or combination thereof. In some embodiments, the emollients comprise C9-12 alkane, C13-15 alkane, C13-16 isoalkane, squalane, undecane, tridecane, decane, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, caprylyl caprylate / caprate, or combinations thereof.

[0133] In some embodiments, the composition comprises a emollient comprising polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate (dispersant / solubilizer), dicaprylyl maleate (solubilizer), dilinoleic acid / propanediol copolymer (solubilizer), isoamyl laurate (refatting + foam- improving), oleic acid, isohexadecane, squalane, isopropyl palmitate, *polycitronellol, *diheptyl succinate, *capryloyl glycerin / sebacic acid copolymer, C12-15 alkyl benzoate, caprylic / capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl -64-WSGR Ref.63230-735.601 piperidinyl dimethicone, castor oil / IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate / dicaprate (dispersant), propylene glycol dicaprylate / dicaprate, triolein (algae oil), propylene glycol dicaprylate / dicaprate, phytosteryl / octyldodecyl lauroyl glutamate, phytosteryl / behenyl / octyldodecyl lauroyl glutamate, phytosteryl / decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, *[sclerocarya birrea seed oil, tetradecane], isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid / trimethylolpropane copolymer, pentaerythrityl stearate / caprate / caprylate / adipate, neopentyl glycol diethylhexanoate, [Heavy] pentaerythrityl tetraisostearate, bis-behenyl / isostearyl / phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, [Light] *isoamyl laurate, *isoamyl cocoate, *hemisqualane, *polycitronellol acetate, *ethyl macadamiate, *coco-caprylate / caprate, *coconut alkanes, *C9-12 alkane, *C13-15 alkane, *C13-16 isoalkane (C13-16 isoparaffin), *neopentyl glycol diheptanoate, *hydrogenated ethylhexyl olivate, *hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, castor isostearate succinate, caprylyl caprylate / caprate [RLF], isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Isopropyl Palmitate, Isopropyl Palmitate, dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. (*silicone replacement included)

[0134] In some embodiments, the polysorbate comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, or a combination of two or more thereof.

[0135] In some embodiments, the fatty alcohol comprises myristyl alcohol, palmityl alcohol, stearyl alcohol, cetyl alcohol, cetearyl alcohol, or a combination of two or more thereof.

[0136] In some embodiments, the ester comprises ethylhexyl palmitate, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, methylheptyl isostearate, polyglyceryl-2- diisostearate, di-C12-15 alkyl fumarate, triisostearin, myristyl myristate, palmityl palmitate, myristyl palmitate, tridecyl trimellitate, pentaerythrityl tetraethylhexanoate.

[0137] In some embodiments, the ether comprises dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. -65-WSGR Ref.63230-735.601

[0138] In some embodiments, the emollient comprises polysorbate 20, polysorbate 30, polysorbate 40, fructose, cetyl alcohol, paraffin, sorbitol, glycerin, lanolin, hyaluronic acid, mineral oil, dimethicone, castor isostearate succinate, cetearyl alcohol, sunflower oil, dicaprylyl ether, or a combination of two or more thereof.

[0139] In some embodiments, the emollient comprises a natural oil comprising coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil, or a combination of two or more thereof. In some embodiments, the emollient comprises coconut oil. In some embodiments, the emollient comprises argan oil. In some embodiments, the emollient comprises jojoba oil. In some embodiments, the emollient comprises olive oil. In some embodiments, the emollient comprises avocado oil. In some embodiments, the emollient comprises sunflower oil. In some embodiments, the emollient comprises castor oil. In some embodiments, the emollient comprises Phenethyl benzoate. In some embodiments, the emollient comprises Dicaprylyl maleate. In some embodiments, the emollient comprises Dilinoleic acid / propanediol copolymer. In some embodiments, the emollient comprises isoamyl laurate. In some embodiments, the emollient comprises Oleic acid. In some embodiments, the emollient comprises isohexadecane. In some embodiments, the emollient comprises C9-C12 alkane. In some embodiments, the emollient comprises C13-C15 alkane. In some embodiments, the emollient comprises C13-C16 isoalkane. In some embodiments, the emollient comprises squalane. In some embodiments, the emollient comprises undecane. In some embodiments, the emollient comprises tridecane. In some embodiments, the emollient comprises isopropyl palmitate. In some embodiments, the emollient comprises *polycitronellol. In some embodiments, the emollient comprises *diheptyl succinate. In some embodiments, the emollient comprises *capryloyl glycerin / sebacic acid copolymer. In some embodiments, the emollient comprises C12-15 alkyl benzoate. In some embodiments, the emollient comprises caprylic / capric triglycerides. In some embodiments, the emollient comprises PPG-3 benzyl ether ethylhexanoate. In some embodiments, the emollient comprises Hydrogenated vegetable oil. In some embodiments, the emollient comprises Triheptanoin. In some embodiments, the emollient comprises Diisopropyl sebacate. In some embodiments, the emollient comprises Diisopropyl adipate. In some embodiments, the emollient comprises Propylene glycol dibenzoate. In some embodiments, the emollient comprises Propoxytetramethyl piperidinyl dimethicone. In some embodiments, the emollient comprises castor oil / IPDI copolymer. In some embodiments, the emollient comprises Butylene glycol cocoate. In some embodiments, the emollient comprises Butylene glycol dicaprylate / dicaprate. In some embodiments, the emollient comprises Triolein (algae oil). In some embodiments, the emollient comprises Propylene glycol dicaprylate / dicaprate. In some embodiments, the -66-WSGR Ref.63230-735.601 emollient comprises Phytosteryl / octyldodecyl lauroyl glutamate. In some embodiments, the emollient comprises Phytosteryl / behenyl / octyldodecyl lauroyl glutamate. In some embodiments, the emollient comprises Phytosteryl / decyltetradecyl myristoyl methyl beta-alaninate. In some embodiments, the emollient comprises Isopropyl lauroyl sarcosinate. In some embodiments, the emollient comprises C10-18 triglycerides. In some embodiments, the emollient comprises *[sclerocarya birrea seed oil, tetradecane]. In some embodiments, the emollient comprises Isoeicosane. In some embodiments, the emollient comprises Lauryl laurate. In some embodiments, the emollient comprises Tridecyl neopentanoate. In some embodiments, the emollient comprises Isostearyl palmitate. In some embodiments, the emollient comprises Isostearyl isostearate. In some embodiments, the emollient comprises Cocoyl adipic acid / trimethylolpropane copolymer. In some embodiments, the emollient comprises Pentaerythrityl stearate / caprate / caprylate / adipate. In some embodiments, the emollient comprises Neopentyl glycol diethylhexanoate. In some embodiments, the emollient comprises [Heavy] Pentaerythrityl tetraisostearate. In some embodiments, the emollient comprises Bis- behenyl / isostearyl / phytosteryl dimer dilinoleyl dimer dilinoleate. In some embodiments, the emollient comprises Diisostearyl malate (DISM). In some embodiments, the emollient comprises Polybutene [indopol]. In some embodiments, the emollient comprises Polyisobutene. In some embodiments, the emollient comprises Hydrogenated polyisobutene. In some embodiments, the emollient comprises Hydrogenated polydecene. In some embodiments, the emollient comprises [Light] *Isoamyl laurate. In some embodiments, the emollient comprises *Isoamyl cocoate. In some embodiments, the emollient comprises *Hemisqualane. In some embodiments, the emollient comprises *Polycitronellol acetate. In some embodiments, the emollient comprises *Ethyl macadamiate. In some embodiments, the emollient comprises *Coco-caprylate / caprate. In some embodiments, the emollient comprises *Coconut alkanes. In some embodiments, the emollient comprises *C9-12 alkane. In some embodiments, the emollient comprises *C13-15 alkane. In some embodiments, the emollient comprises *C13-16 isoalkane (C13-16 isoparaffin). In some embodiments, the emollient comprises *neopentyl glycol diheptanoate. In some embodiments, the emollient comprises *hydrogenated ethylhexyl olivate. In some embodiments, the emollient comprises *hydrogenated olive oil unsaponifiables. In some embodiments, the emollient comprises undecane. In some embodiments, the emollient comprises tridecane. In some embodiments, the emollient comprises isododecane. In some embodiments, the emollient comprises caprylyl caprylate / caprate. In some embodiments, the emollient comprises isononyl isononanoate. In some embodiments, the emollient comprises Isodecyl neopentanoate. In some embodiments, the emollient comprises one or more oils -67-WSGR Ref.63230-735.601 comprising olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, or isopropyl palmitate, or a combination thereof. (*silicone replacements included).

[0140] In some embodiments, the emollient comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin / sebacic acid copolymer, C12-15 alkyl benzoate, caprylic / capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil / IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate / dicaprate, propylene glycol dicaprylate / dicaprate, triolein (algae oil), propylene glycol dicaprylate / dicaprate, phytosteryl / octyldodecyl lauroyl glutamate, phytosteryl / behenyl / octyldodecyl lauroyl glutamate, phytosteryl / decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, sclerocarya birrea seed oil, tetradecane, isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid / trimethylolpropane copolymer, pentaerythrityl stearate / caprate / caprylate / adipate, neopentyl glycol diethylhexanoate, pentaerythrityl tetraisostearate, bis-behenyl / isostearyl / phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate / caprate, coconut alkanes, C9-12 alkane, C13-15 alkane, C13-16 isoalkane C13-16 isoparaffin, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate / caprate, castor isostearate succinate, isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, Sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, isopropyl palmitate, isopropyl palmitate, dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. -68-WSGR Ref.63230-735.601

[0141] In some embodiments, the composition comprises a emollient selected from: Phenethyl benzoate (dispersant / solubilizer), dicaprylyl maleate (solubilizer), dilinoleic acid / propanediol copolymer (solubilizer), isoamyl laurate (refatting + foam-improving), oleic acid, isohexadecane, squalane, isopropyl palmitate, *polycitronellol, *diheptyl succinate, *capryloyl glycerin / sebacic acid copolymer, C12-15 alkyl benzoate, caprylic / capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil / IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate / dicaprate (dispersant), propylene glycol dicaprylate / dicaprate, triolein (algae oil), propylene glycol dicaprylate / dicaprate, phytosteryl / octyldodecyl lauroyl glutamate, phytosteryl / behenyl / octyldodecyl lauroyl glutamate, phytosteryl / decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, *[sclerocarya birrea seed oil, tetradecane], isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid / trimethylolpropane copolymer, pentaerythrityl stearate / caprate / caprylate / adipate, neopentyl glycol diethylhexanoate, [Heavy] pentaerythrityl tetraisostearate, bis-behenyl / isostearyl / phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, [Light] *isoamyl laurate, *isoamyl cocoate, *hemisqualane, *polycitronellol acetate, *ethyl macadamiate, *coco-caprylate / caprate, *coconut alkanes, *C9-12 alkane, *C13-15 alkane, *C13-16 isoalkane (C13-16 isoparaffin), *neopentyl glycol diheptanoate, *hydrogenated ethylhexyl olivate, *hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate / caprate [RLF], isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Isopropyl Palmitate, Isopropyl Palmitate. (*silicone replacement included)

[0142] In certain embodiments, the emollient comprises Phenethyl benzoate. In certain embodiments, the emollient comprises Dicaprylyl maleate. In certain embodiments, the emollient comprises Dilinoleic acid / propanediol copolymer. In certain embodiments, the emollient comprises Isoamyl laurate. In certain embodiments, the emollient comprises Oleic acid. In certain embodiments, the emollient comprises Isohexadecane. In certain embodiments, the emollient comprises Squalane. In certain embodiments, the emollient comprises Isopropyl palmitate. In certain embodiments, the emollient comprises *Polycitronellol. In certain -69-WSGR Ref.63230-735.601 embodiments, the emollient comprises *Diheptyl succinate. In certain embodiments, the emollient comprises *Capryloyl glycerin / sebacic acid copolymer. In certain embodiments, the emollient comprises C12-15 alkyl benzoate. In certain embodiments, the emollient comprises Caprylic / capric triglycerides. In certain embodiments, the emollient comprises PPG-3 benzyl ether ethylhexanoate. In certain embodiments, the emollient comprises Hydrogenated vegetable oil. In certain embodiments, the emollient comprises Triheptanoin. In certain embodiments, the emollient comprises Diisopropyl sebacate. In certain embodiments, the emollient comprises Diisopropyl adipate. In certain embodiments, the emollient comprises Propylene glycol dibenzoate. In certain embodiments, the emollient comprises Propoxytetramethyl piperidinyl dimethicone. In certain embodiments, the emollient comprises Castor oil / IPDI copolymer. In certain embodiments, the emollient comprises Butylene glycol cocoate. In certain embodiments, the emollient comprises Butylene glycol dicaprylate / dicaprate. In certain embodiments, the emollient comprises Triolein (algae oil). In certain embodiments, the emollient comprises Propylene glycol dicaprylate / dicaprate. In certain embodiments, the emollient comprises Phytosteryl / octyldodecyl lauroyl glutamate. In certain embodiments, the emollient comprises Phytosteryl / behenyl / octyldodecyl lauroyl glutamate. In certain embodiments, the emollient comprises Phytosteryl / decyltetradecyl myristoyl methyl beta-alaninate. In certain embodiments, the emollient comprises Isopropyl lauroyl sarcosinate. In certain embodiments, the emollient comprises C10-18 triglycerides. In certain embodiments, the emollient comprises *[sclerocarya birrea seed oil, tetradecane]. In certain embodiments, the emollient comprises Isoeicosane. In certain embodiments, the emollient comprises Lauryl laurate. In certain embodiments, the emollient comprises Tridecyl neopentanoate. In certain embodiments, the emollient comprises Isostearyl palmitate. In certain embodiments, the emollient comprises Isostearyl isostearate. In certain embodiments, the emollient comprises Cocoyl adipic acid / trimethylolpropane copolymer. In certain embodiments, the emollient comprises Pentaerythrityl stearate / caprate / caprylate / adipate. In certain embodiments, the emollient comprises Neopentyl glycol diethylhexanoate. In certain embodiments, the emollient comprises [Heavy] Pentaerythrityl tetraisostearate. In certain embodiments, the emollient comprises Bis- behenyl / isostearyl / phytosteryl dimer dilinoleyl dimer dilinoleate. In certain embodiments, the emollient comprises Diisostearyl malate (DISM). In certain embodiments, the emollient comprises Polybutene [indopol]. In certain embodiments, the emollient comprises Polyisobutene. In certain embodiments, the emollient comprises Hydrogenated polyisobutene. In certain embodiments, the emollient comprises Hydrogenated polydecene. In certain embodiments, the emollient comprises [Light] *Isoamyl laurate. In certain embodiments, the -70-WSGR Ref.63230-735.601 emollient comprises *Isoamyl cocoate. In certain embodiments, the emollient comprises *Hemisqualane. In certain embodiments, the emollient comprises *Polycitronellol acetate. In certain embodiments, the emollient comprises *Ethyl macadamiate. In certain embodiments, the emollient comprises *Coco-caprylate / caprate. In certain embodiments, the emollient comprises *Coconut alkanes. In certain embodiments, the emollient comprises *C9-12 alkane. In certain embodiments, the emollient comprises *C13-15 alkane. In certain embodiments, the emollient comprises *C13-16 isoalkane (C13-16 isoparaffin). In certain embodiments, the emollient comprises *Neopentyl glycol diheptanoate. In certain embodiments, the emollient comprises *Hydrogenated ethylhexyl olivate. In certain embodiments, the emollient comprises *Hydrogenated olive oil unsaponifiables. In certain embodiments, the emollient comprises Undecane. In certain embodiments, the emollient comprises Tridecane. In certain embodiments, the emollient comprises Isododecane. In certain embodiments, the emollient comprises caprylyl caprylate / caprate [RLF]. In certain embodiments, the emollient comprises Isononyl isononanoate. In certain embodiments, the emollient comprises Isodecyl neopentanoate. In certain embodiments, the emollient comprises one or more oils selected from: Olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Isopropyl Palmitate, Isopropyl Palmitate. (*silicone replacement included)

[0143] In some embodiments, the emollient is present in the composition at a weight% of about 1% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 25% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 30% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 35% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 40% (w / w) of a total weight of the composition. -71-WSGR Ref.63230-735.601

[0144] In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 10% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 15% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 20% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 25% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 30% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 35% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 40% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 10% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 15% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 20% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 25% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 30% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 35% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 40% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 15% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 20% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 25% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 30% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 35% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 40% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% to about 20% (w / w) of a total weight of the composition. In some embodiments, the -72-WSGR Ref.63230-735.601 emollient is present in the composition at a weight% of about 15% to about 25% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% to about 30% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% to about 35% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% to about 40% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% to about 25% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% to about 30% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% to about 35% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% to about 40% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 25% to about 30% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 25% to about 35% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 25% to about 40% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 30% to about 35% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 30% to about 40% (w / w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 35% to about 40% (w / w) of a total weight of the composition.

[0145] In some embodiments, the emollient is present from about 0.1% to about 20% total weight of a conditioner composition. In certain embodiments, the emollient is present from about 0.5% to about 10% total weight of a conditioner composition. In certain embodiments, the emollient is present from about 2% to about 12% total weight of a conditioner composition. In certain embodiments, the emollient is present from about 5% to about 15% total weight of a conditioner composition.

[0146] In certain embodiments, the emollient is present up to about 0.1% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 1% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 2.5% total weight of a conditioner composition. In certain embodiments, the -73-WSGR Ref.63230-735.601 emollient is present up to about 5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 7.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 10% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 12.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 15% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 20% total weight of a conditioner composition.

[0147] In some embodiments, the composition comprises the formulation of any one of Tables 12-14. Table 12Table 13Table 14

[0148] In certain embodiments, the conditioner composition comprises the formulation of Table 83. In certain embodiments, the conditioner composition comprises the formulation of Table 84 or Table 85. Table 83-74-WSGR Ref.63230-735.601Table 84Table 85Preservatives -75-WSGR Ref.63230-735.601

[0149] In some embodiments, the composition described herein further comprises a preservative. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a preservative. In some embodiments, a conditioner composition comprises a preservative.

[0150] Preservatives generally refer to and include, but are not limited to, substances that help maintain the stability, safety, and efficacy of the composition throughout its shelf life and usage. Examples include but are not limited to: caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof.

[0151] In some embodiments, the composition comprises a preservative. In some embodiments, the composition comprises one or more preservatives. In some embodiments, the composition comprises two or more preservatives. In some embodiments, the composition comprises three or more preservatives. In some embodiments, the composition comprises four or more preservatives. In some embodiments, the one or more preservatives comprises caprylyl glycol, caprylhydroxamic acid, sodium benzoate, benzyl alcohol, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, and sodium benzoate.

[0152] In some embodiments, the preservative comprises caprylyl glycol. In some embodiments, the preservative comprises caprylhydroxamic acid. In some embodiments, the preservative comprises sodium benzoate. In some embodiments, the preservative comprises benzyl alcohol. In some embodiments, the preservative comprises potassium sorbate. In some embodiments, the preservative comprises phenoxyethanol. In some embodiments, the preservative comprises ethylhexylglycerin. In some embodiments, the preservative comprises gluconolactone. In some embodiments, the preservative comprises sodium benzoate. In some embodiments, the preservative comprises gluconolactone, sodium benzoate, or both. In some embodiments, the preservative comprises gluconolactone, sodium benzoate, phenoxyethanol, or combinations thereof.

[0153] In some embodiments, the preservative comprises caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof. In some embodiments, the preservative comprises caprylyl glycol and one or more of caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination of two or more thereof. In some embodiments, the preservative comprises ethylhexylglycerin and one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination or two or more thereof. In -76-WSGR Ref.63230-735.601 some embodiments, the preservative comprises benzyl alcohol and one or more of potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, or sodium benzoate, or a combination of two or more thereof. In some embodiments, the preservative comprises benzyl alcohol and phenoxyethanol and one or more of potassium sorbate, ethylhexylglycerin, gluconolactone, or sodium benzoate, or a combination of two or more thereof. In some embodiments, the preservative comprises one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof.

[0154] In some embodiments, the preservative is present from about 0.01% to about 5% total weight of a composition. In some embodiments, the preservative is present from about 0.1% to about 2% total weight of a composition. In some embodiments, the preservative is present from about 0.5% to about 2% total weight of a composition. In some embodiments, the preservative is present from about 1% to about 5% total weight of a composition.

[0155] In some embodiments, the preservative is present up to about 0.005% total weight of a composition. In some embodiments, the preservative is present up to about 0.01% total weight of a composition. In some embodiments, the preservative is present up to about 0.05% total weight of a composition. In some embodiments, the preservative is present up to about 0.1% total weight of a composition. In some embodiments, the preservative is present up to about 0.5% total weight of a composition. In some embodiments, the preservative is present up to about 0.75% total weight of a composition. In some embodiments, the preservative is present up to about 1% total weight of a composition. In some embodiments, the preservative is present up to about 1.5% total weight of a composition. In some embodiments, the preservative is present up to about 2% total weight of a composition. In some embodiments, the preservative is present up to about 2.5% total weight of a composition. In some embodiments, the preservative is present up to about 3% total weight of a composition. In some embodiments, the preservative is present up to about 4% total weight of a composition. In some embodiments, the preservative is present up to about 5% total weight of a composition.

[0156] In some embodiments, the composition comprises the formulation of any one of Table 15, Table 16, Table 17, or Table 18. Table 15-77-WSGR Ref.63230-735.601Table 16Table 17Table 18

[0157] In certain embodiments, the conditioner composition comprises the formulation of Table 89. In certain embodiments, the conditioner composition comprises the formulation of Table 90 or Table 91. Table 89-78-WSGR Ref.63230-735.601Table 90Table 91Emulsifiers -79-WSGR Ref.63230-735.601

[0158] In some embodiments, the composition described herein further comprises an emulsifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an emulsifier. In some embodiments, a conditioner composition comprises an emulsifier.

[0159] Emulsifiers generally refer to and include, but are not limited to, ingredients that blend and stabilize a mixture of water-based and oil-based ingredients in a composition. In some embodiments, emulsifiers enable dispersion of oil-based ingredients within a water-based solvent or water-based ingredients in an oil-based solvent. Examples of emulsifiers include but are not limited to: fatty alcohol ethoxylates (e.g., ceteareth-20, ceteareth-25), sorbitan esters (e.g., sorbitan oleate, sorbitan stearate), PEG esters (e.g., PEG-40 hydrogenated castor oil, PEG- 100 stearate), quaternary ammonium compounds (e.g., behentrimonium chloride), polyquaternium compounds (e.g., polyquaternium-10), ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80), glyceryl esters (e.g., glyceryl stearate), cationic surfactants (e.g., cetrimonium chloride), nonionic emulsifiers (e.g., glyceryl oleate), and amphiphilic compounds (e.g., lecithin, phospholipids).

[0160] In some embodiments, the composition described herein comprises an emulsifier. In some embodiments, the composition comprises one or more emulsifiers. In some embodiments, the one or more emulsifiers are comprising fatty alcohol ethoxylates (e.g., ceteareth-20, ceteareth-25), sorbitan esters (e.g., sorbitan oleate, sorbitan stearate), PEG esters (e.g., PEG-40 hydrogenated castor oil, PEG-100 stearate), quaternary ammonium compounds (e.g., behentrimonium chloride), polyquaternium compounds (e.g., polyquaternium-10), ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80), glyceryl esters (e.g., glyceryl stearate), cationic surfactants (e.g., cetrimonium chloride), nonionic emulsifiers (e.g., glyceryl oleate), and amphiphilic compounds (e.g., lecithin, phospholipids). In some embodiments, the emulsifier comprises ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80).

[0161] In some embodiments, the one or more emulsifiers is selected from lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate / stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 -80-WSGR Ref.63230-735.601 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla / jojoba / rice bran polyglyceryl- 3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate / stearate, candelilla / jojoba / rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, polyhydroxystearic acid.

[0162] In some embodiments, the emulsifier comprises lecithin. In some embodiments, the emulsifier comprises hydrogenated lecithin. In some embodiments, the emulsifier comprises phosphatidylcholine. In some embodiments, the emulsifier comprises [C12-16 alcohols, palmitic acid]. In some embodiments, the emulsifier comprises glyceryl behenate. In some embodiments, the emulsifier comprises glyceryl stearate. In some embodiments, the emulsifier comprises glyceryl stearate citrate. In some embodiments, the emulsifier comprises glyceryl oleate citrate. In some embodiments, the emulsifier comprises sorbitan laurate. In some embodiments, the emulsifier comprises lauryl laurate. In some embodiments, the emulsifier comprises sorbitan olivate. In some embodiments, the emulsifier comprises cetearyl olivate. In some embodiments, the emulsifier comprises sodium stearoyl lactylate. In some embodiments, the emulsifier comprises sodium stearoyl glutamate. In some embodiments, the emulsifier comprises sodium cocoyl glutamate. In some embodiments, the emulsifier comprises caprylyl / capryl glucoside. In some embodiments, the emulsifier comprises polyhydroxystearic acid. In some embodiments, the emulsifier comprises phenethyl alcohol. In some embodiments, the emulsifier comprises sodium surfactin. In some embodiments, the emulsifier comprises polyglycerin-3. In some embodiments, the emulsifier comprises polyglyceryl-3 distearate. In some embodiments, the emulsifier comprises polyglyceryl-3 diisostearate. In some embodiments, the emulsifier comprises polyglyceryl-3 cocoate. In some embodiments, the emulsifier comprises polyglyceryl- 3 dicitrate / stearate. In some embodiments, the emulsifier comprises polyglyceryl-3 beeswax. In some embodiments, the emulsifier comprises polyglyceryl-3 polyricinoleate. In some embodiments, the emulsifier comprises polyglyceryl-4 oleate. In some embodiments, the emulsifier comprises polyglyceryl-4 caprate. In some embodiments, the emulsifier comprises polylgylceryl-4 laurate. In some embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In some embodiments, the emulsifier comprises polyglyceryl-6 stearate. In some embodiments, the emulsifier comprises polyglyceryl-6 distearate. In some embodiments, the emulsifier comprises polyglyceryl-6 behenate. In some embodiments, the emulsifier comprises -81-WSGR Ref.63230-735.601 polyglyceryl-6 polyhydroxystearate. In some embodiments, the emulsifier comprises polyglyceryl-6 oleate. In some embodiments, the emulsifier comprises polyglyceryl-6 ricinoleate. In some embodiments, the emulsifier comprises polyglyceryl-6 polyricinoleate. In some embodiments, the emulsifier comprises polyglyceryl-10 laurate. In some embodiments, the emulsifier comprises candelilla / jojoba / rice bran polyglyceryl-3 esters. In some embodiments, the emulsifier comprises stearoyl glutamic acid. In some embodiments, the emulsifier comprises stearyl alcohol. In some embodiments, the emulsifier comprises glyceryl stearate citrate. In some embodiments, the emulsifier comprises glyceryl oleate citrate. In some embodiments, the emulsifier comprises polyglyceryl-3 distearate. In some embodiments, the emulsifier comprises glyceryl stearate citrate. In some embodiments, the emulsifier comprises polyglyceryl-3 dicitrate / stearate. In some embodiments, the emulsifier comprises candelilla / jojoba / rice bran polyglyceryl-3 esters. In some embodiments, the emulsifier comprises polyglyceryl-6 stearate. In some embodiments, the emulsifier comprises polyglyceryl-6 behenate. In some embodiments, the emulsifier comprises polysorbate-20. In some embodiments, the emulsifier comprises polyglyceryl-10 laurate. In some embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In some embodiments, the emulsifier comprises polyglyceryl-3 cocoate. In some embodiments, the emulsifier comprises polyglyceryl-4 caprate. In some embodiments, the emulsifier comprises polyglyceryl-6 ricinoleate. In some embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In some embodiments, the emulsifier comprises sodium surfactin. In some embodiments, the emulsifier comprises polyhydroxystearic acid.

[0163] In some embodiments, the emulsifier is present from about 0.1% to about 20% total weight of a composition. In some embodiments, the emulsifier is present from about 1% to about 10% by total weight of the composition. In some embodiments, the emulsifier is present from about 0.5% to about 10% total weight of a composition. In some embodiments, the emulsifier is present from about 2% to about 12% total weight of a composition. In some embodiments, the emulsifier is present from about 2% to about 10% total weight of a composition. In some embodiments, the emulsifier is present from about 1% to about 5% total weight of a composition. In some embodiments, the emulsifier is present at about 1% (w / w), about 2% (w / w), about 5% (w / w), or about 10% (w / w) of a total weight of the composition.

[0164] In some embodiments, the emulsifier is present up to about 0.1% total weight of a composition. In some embodiments, the emulsifier is present up to about 0.5% total weight of a composition. In some embodiments, the emulsifier is present up to about 1% total weight of a composition. In some embodiments, the emulsifier is present up to about 2.5% total weight of a composition. In some embodiments, the emulsifier is present up to about 5% total weight of a -82-WSGR Ref.63230-735.601 composition. In some embodiments, the emulsifier is present up to about 7.5% total weight of a composition. In some embodiments, the emulsifier is present up to about 10% total weight of a composition. In some embodiments, the emulsifier is present up to about 12.5% total weight of a composition. In some embodiments, the emulsifier is present up to about 15% total weight of a composition. In some embodiments, the emulsifier is present up to about 20% total weight of a composition.

[0165] In some embodiments, the composition comprises the formulation of any one of Table 19, Table 20, or Table 21. Table 19Table 20Table 21

[0166] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an emulsifier. In some embodiments, the emulsifier comprises: natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters. In -83-WSGR Ref.63230-735.601 some embodiments, the emulsifier comprises: lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate / stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla / jojoba / rice bran polyglyceryl-3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate / stearate, candelilla / jojoba / rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or polyhydroxystearic acid. In some embodiments, the emulsifier is selected from a group consisting of: natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, and synthetic esters. In some embodiments, the emulsifier is selected from a group consisting of: lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate / stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla / jojoba / rice bran polyglyceryl-3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate / stearate, candelilla / jojoba / rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 -84-WSGR Ref.63230-735.601 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, and polyhydroxystearic acid.

[0167] In certain embodiments, the conditioner composition comprises the formulation of Table 73. In certain embodiments, the conditioner composition comprises the formulation of Table 74 or Table 75. Table 73Table 74Table 75Conditioning Agents

[0168] In some embodiments, the composition described herein further comprises a conditioning agent. In some embodiments, the composition comprising a polypeptide and a lipid -85-WSGR Ref.63230-735.601 nanoparticle further comprises a conditioning agent. In some embodiments, a conditioner composition comprises a conditioning agent.

[0169] Conditioning agents generally refer to and include, but are not limited to, substances that enhance the texture, manageability, and overall feel of hair. In certain instances, conditioning agents work by forming a thin film on the surface of the hair, reducing friction between individual strands, and helping to smooth the cuticle layer. In some embodiments, the conditioning agent increases moisture of hair, scalp, or both. Examples include but are not limited to: quaternary ammonium compounds (e.g., cetrimonium chloride, behentrimonium chloride), proteins (e.g., hydrolyzed wheat protein, hydrolyzed keratin, silk proteins), polysaccharides (e.g., hydrolyzed wheat starch, hyaluronic acid or hyaluronan (HA), heparan sulfate (HS), heparin (HP)), esters (e.g., cetyl esters, dilinoleyl esters, cococarpylate / caprate), silicones (e.g., dimethicone), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol), humectants (e.g., glycerin, panthenol), polyquaternium compounds (e.g., polyquaternium-7, polyquaternium-10), cationic polymers (e.g., polyquaternium-16, polyquaternium-37), ceramides, and aloe vera.

[0170] In some embodiments, the conditioning agent comprises a protein comprising hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof.

[0171] In some embodiments, the composition comprises a conditioning agent. In some embodiments, the composition comprises one or more conditioning agents. In some embodiments, the one or more conditioning agents comprise quaternium-18 bentonite, quaternium-22 hectonite, behentrimonium methosulfate, behentrimonium chloride, benzethonium chloride, benzalkonium chloride, cetrimonium chloride, cetrimonium methosulfate, steartrimonium chloride, stearalkonium chloride, dicetyldimonium chloride, tricetyldimonium chloride, cocotrimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, PCA ethyl cocoyl arginate, C10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butter, amidopropyltrimonium chloride, hydrolyzed wheat protein, hydrolyzed keratin, hydrolyzed silk protein, hydrolyzed wheat starch, quaternium-15, quaternium-87, polyquaternium-10, quaternium-22, polyquaternium-57, quaternary ammonium compounds, binnamidopropyltrimonium chloride, behentrimonium chloride, steralkonium chloride, jojoba esters, hydroxypropyl guar hydroxypropyltrimonium chloride, or a combination thereof. In some embodiments, the one or more conditioning agents are selected from quaternium-18 bentonite, quaternium-22 hectonite, behentrimonium methosulfate, -86-WSGR Ref.63230-735.601 behentrimonium chloride, benzethonium chloride, benzalkonium chloride, cetrimonium chloride, cetrimonium methosulfate, steartrimonium chloride, stearalkonium chloride, dicetyldimonium chloride, tricetyldimonium chloride, cocotrimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, PCA ethyl cocoyl arginate, C10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butteramidopropyltrimonium chloride, hydrolyzed wheat protein, hydrolyzed keratin, hydrolyzed silk protein, hydrolyzed wheat starch, quaternium-15, quaternium-87, polyquaternium-10, quaternium-22, polyquaternium-57, quaternary ammonium compounds, binnamidopropyltrimonium chloride, behentrimonium chloride, steralkonium chloride, jojoba esters, and hydroxypropyl guar hydroxypropyltrimonium chloride. In some embodiments, the conditioning agent comprises quaternium-18 bentonite. In some embodiments, the conditioning agent comprises quaternium-22 hectonite. In some embodiments, the conditioning agent comprises behentrimonium methosulfate. In some embodiments, the conditioning agent comprises behentrimonium chloride. In some embodiments, the conditioning agent comprises behentrimonium chloride, hydrolyzed wheat protein, or both. In some embodiments, the conditioning agent comprises benzethonium chloride. In some embodiments, the conditioning agent comprises benzalkonium chloride. In some embodiments, the conditioning agent comprises cetrimonium chloride. In some embodiments, the conditioning agent comprises cetrimonium methosulfate. In some embodiments, the conditioning agent comprises steartrimonium chloride. In some embodiments, the conditioning agent comprises stearalkonium chloride. In some embodiments, the conditioning agent comprises dicetyldimonium chloride. In some embodiments, the conditioning agent comprises tricetyldimonium chloride. In some embodiments, the conditioning agent comprises cocotrimonium chloride. In some embodiments, the conditioning agent comprises dicocodimonium chloride. In some embodiments, the conditioning agent comprises laurtrimonium chloride. In some embodiments, the conditioning agent comprises hydrolyzed wheat protein. In some embodiments, the conditioning agent comprises hydrolyzed keratin. In some embodiments, the conditioning agent comprises hydrolyzed wheat starch. In some embodiments, the conditioning agent comprises hyaluronic acid or hyaluronan (HA). In some embodiments, the conditioning agent comprises cetyl esters. In some embodiments, the conditioning agent comprises coco caprylate / caprate. In some embodiments, the conditioning agent comprises stearamidopropyl dimethylamine. In some embodiments, the conditioning agent comprises PCA ethyl cocoyl arginate. In some embodiments, the conditioning agent comprises C10-40 isoalkylamidopropylethyldimonium ethosulfate. In some embodiments, the conditioning agent comprises dipalmitoylethyl -87-WSGR Ref.63230-735.601 hydroxyethylmonium methosulfate. In some embodiments, the conditioning agent comprises shea butter amidopropyltrimonium chloride. In some embodiments, the conditioning agent comprises quaternium-15. In some embodiments, the conditioning agent comprises quaternium- 18. In some embodiments, the conditioning agent comprises quaternium-87. In some embodiments, the conditioning agent comprises polyquaternium-10. In some embodiments, the conditioning agent comprises quaternium-22. In some embodiments, the conditioning agent comprises polyquaternium-57. In certain embodiments, the conditioning agent comprises quaternary ammonium compounds. In certain embodiments, the conditioning agent comprises binnamidopropyltrimonium chloride. In certain embodiments, the conditioning agent comprises behentrimonium chloride. In certain embodiments, the conditioning agent comprises steralkonium chloride. In certain embodiments, the conditioning agent comprises jojoba esters. In certain embodiments, the conditioning agent comprises hydroxypropyl guar hydroxypropyltrimonium chloride. In some embodiments, the conditioning agent comprises hydroxypropyl guar hydroxypropyltrimonium chloride, behentrimonium chloride, steralkonium chloride, jojoba esters, or combinations thereof.

[0172] In some embodiments, the conditioning agent comprises a silicone, a quaternary ammonium compound, a fatty alcohol, a natural oil, a cationic polymer, a ceramide, or a polysaccharide, or a combination of two or more thereof. In some embodiments, the conditioning agent comprises a natural oil, ester, polysaccharide, or a combination of two or more thereof. In some embodiments, the silicone comprises dimethicone, cyclomethicone, cyclopentasiloxane, amodimethicone, PEG-12 dimethicone, dimethiconol, phenyl trimethicone, dimethicone copolyol, stearoxy dimethicone, or behenoxy dimethicone, or a combination of two or more thereof. In some embodiments, the quaternary ammonium compound comprises cetrimonium chloride, behentrimonium chloride, or both.

[0173] In some embodiments, the conditioning agent is present from 0.1% to 20% total weight of a composition. In some embodiments, the conditioning agent is present from 0.5% to 10% total weight of a composition. In some embodiments, the conditioning agent is present from 1% to 10% total weight of a composition. In some embodiments, the conditioning agent other than water is present from 1% to 10% total weight of a composition. In some embodiments, the conditioning agent other than water is present from 1% to 5% total weight of a composition.

[0174] In some embodiments, the conditioning agent is present up to 0.1% total weight of a composition. In some embodiments, the conditioning agent is present up to 0.5% total weight of a composition. In some embodiments, the conditioning agent is present up to 1% total weight of -88-WSGR Ref.63230-735.601 a composition. In some embodiments, the conditioning agent is present up to 2% total weight of a composition. In some embodiments, the conditioning agent is present up to 3% total weight of a composition. In some embodiments, the conditioning agent is present up to 5% total weight of a composition. In some embodiments, the conditioning agent is present up to 6% total weight of a composition. In some embodiments, the conditioning agent is present up to 10% total weight of a composition. In some embodiments, the conditioning agent is present up to 15% total weight of a composition. In some embodiments, the conditioning agent is present up to 20% total weight of a composition.

[0175] In some embodiments, the composition comprises the formulation of Table 22, Table 23, Table 24, Table 25, or Table 26. Table 22Table 23Table 24-89-WSGR Ref.63230-735.601 Table 25Table 26

[0176] In certain embodiments, the conditioner composition comprises the formulation of Table 76 or Table 77. In certain embodiments, the conditioner composition comprises the formulation of Table 78 or Table 79. Table 76Table 77-90-WSGR Ref.63230-735.601Table 78Table 79pH & pH modifiers

[0177] In some embodiments, a composition described herein further comprises a pH modifier (also referred to as buffer or buffering agent). In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a pH modifier. In some embodiments, a conditioner composition comprises a pH modifier.

[0178] pH modifiers generally refer to and include, but are not limited to, substances that help maintain the stability, safety, and efficacy of the composition throughout its shelf life and usage. Examples include but are not limited to: citric acid, sodium citrate, sodium hydroxide, triethanolamine (TEA), lactic acid, sodium lactate, phosphoric acid, potassium hydroxide, and glycolic acid, or a conjugate acid or a conjugate base thereof as pH modifiers in compositions.

[0179] In some embodiments, the composition comprises a pH modifier. In some embodiments, the composition comprises one or more pH modifiers. In some embodiments, the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, -91-WSGR Ref.63230-735.601 sodium citrate, potassium hydroxide, or glycolic acid, or a combination thereof. In some embodiments, the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, and glycolic acid. In some embodiments, the pH modifier comprises citric acid, sodium hydroxide, or both. In some embodiments, the pH modifier comprises citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, gluconic acid, glucuronic acid, azelaic acid, acetic acid, sodium hydroxide, triethanolamine, and L-arginine, a conjugate acid or a conjugate base thereof.

[0180] In some embodiments, the pH modifier comprises citric acid. In some embodiments, the pH modifier comprises lactic acid. In some embodiments, the pH modifier comprises glycolic acid. In some embodiments, the pH modifier comprises tartaric acid. In some embodiments, the pH modifier comprises malic acid. In some embodiments, the pH modifier comprises gluconic acid. In some embodiments, the pH modifier comprises glucuronic acid. In some embodiments, the pH modifier comprises azelaic acid. In some embodiments, the pH modifier comprises acetic acid. In some embodiments, the pH modifier comprises sodium hydroxide. In some embodiments, the pH modifier comprises triethanolamine. In some embodiments, the pH modifier comprises L- arginine. In some embodiments, the pH modifier comprises potassium hydroxide.

[0181] In some embodiments, the pH modifier is present from about 0.01% to about 2% total weight of a composition. In some embodiments, the pH modifier is present from about 0.1% to about 2% total weight of a composition. In some embodiments, the pH modifier is present from about 0.5% to about 2% total weight of a composition. In some embodiments, the pH modifier is present from about 0.5% to about 1.5% total weight of a composition.

[0182] In some embodiments, the pH modifier is present up to about 0.05% total weight of a composition. In some embodiments, the pH modifier is present up to about 0.1% total weight of a composition. In some embodiments, the pH modifier is present up to about 0.5% total weight of a composition. In some embodiments, the pH modifier is present up to about 0.75% total weight of a composition. In some embodiments, the pH modifier is present up to about 1% total weight of a composition. In some embodiments, the pH modifier is present up to about 1.5% total weight of a composition. In some embodiments, the pH modifier is present up to about 2% total weight of a composition. In some embodiments, the pH modifier is present up to about 2.5% total weight of a composition.

[0183] In some embodiments, the pH of the composition is about 4 and about 8. In some embodiments, the pH of the composition is about 4 and about 7. In some embodiments, the pH of the composition is about 4 and about 6. In some embodiments, the pH of the composition is about 5 and about 8. In some embodiments, the pH of the composition is about 5 and about 7. In some -92-WSGR Ref.63230-735.601 embodiments, the pH of the composition is about 5 and about 6. In some embodiments, the pH of the composition is about 4. In some embodiments, the pH of the composition is about 4.5. In some embodiments, the pH of the composition is about 5. In some embodiments, the pH of the composition is about 5.5 In some embodiments, the pH of the composition is about 6. In some embodiments, the pH of the composition is about 6.5. In some embodiments, the pH of the composition is about 7.

[0184] In some embodiments, the composition comprises the formulation of Table 27, Table 28, Table 29, Table 30, or Table 31. Table 27Table 28Table 29-93-WSGR Ref.63230-735.601 Table 30Table 31

[0185] In certain embodiments, the conditioner composition comprises the formulation of Table 92. In certain embodiments, the conditioner composition comprises the formulation of Table 93 or Table 94. Table 92-94-WSGR Ref.63230-735.601Table 93Table 94

[0186] In some embodiments, the composition comprising a polypeptide and one or more cleansing agents is a cleanser. In some embodiments, the composition described herein comprising a polypeptide and one or more cleansing agents further comprises a pH modifier. In some embodiments, the pH modifier stabilizes a pH of the composition that enables the one or more cleansing agents to remove oil, sebum, build-up, or the like from hair and / or scalp. -95-WSGR Ref.63230-735.601

[0187] In some embodiments, the composition comprising a polypeptide and a detoxifying agent is a cleanser. In some embodiments, the composition described herein comprising a polypeptide and a detoxifying agent further comprises a pH modifier.

[0188] In some embodiments, the cleanser described herein cleans the hair while maintaining an optimum pH environment of hair to minimize fiber swelling and preserve structural integrity. Additionally, the hair cleansers clean the scalp while maintaining an optimum pH environment to avoid over drying the scalp and without disrupting the natural barrier function of the scalp. The cleansers described herein have a pH optimized to cleanse the hair and scalp. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of certain ingredients in the compositions. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of salicylic acid. In some embodiments, the pH of the composition is optimized to promote chelation of certain minerals and metals. In some embodiments, the pH of the composition is optimized to minimize swelling of the cuticle. In some embodiments, reduced swelling of the cuticle reduces tangling of the hair. In some embodiments, the pH of the composition is optimized to protect the structural integrity of the hair and mitigate protein and lipid loss.

[0189] In some embodiments, the cleanser has a pH about 1 to about 7. In some embodiments, the cleanser has a pH of about 1, about 1.25 about 1.5, about 1.75, about 2, about 2.25, about 2.5, about 2.75, about 3, about 3.25, about 3.5, about 3.75, about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, about 7, and any values therebetween. In some embodiments, the cleanser has a pH about 1 to about 7, about 2 to about 7, about 3 to about 7, about 2 to about 6, about 3.5 to about 7, about 4 to about 7, about 4 to about 6. In some embodiments, pH of the cleanser is about 4 to about 8, about 4 to about 7, about 4 to about 6, or any values therebetween. Antioxidants

[0190] In some embodiments, a composition described herein further comprises an antioxidant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an antioxidant. In some embodiments, a conditioner composition comprises an antioxidant.

[0191] Antioxidants generally refer to and include, but are not limited to, ingredients having a role in protecting the hair from damage caused by free radicals. Examples of antioxidants include but are not limited to vitamins (e.g., Vitamin E (tocopherol), Vitamin E or derivatives thereof (tocopheryl acetate), Vitamin C, Vitamin A), polyphenols (e.g., Green Tea Extract, Grapeseed Extract), flavonoids (e.g., Chamomile Extract), carotenoids (e.g., beta-carotene), fatty -96-WSGR Ref.63230-735.601 acids and oils (e.g., Argan Oil, Coconut Oil), enzymes (e.g., Superoxide Dismutase), ubiquinone (e.g., Coenzyme Q10), ascorbic acid (e.g., Vitamin C), and ferulic acid.

[0192] In some embodiments, the composition comprises an antioxidant. In some embodiments, the antioxidant comprises a vitamin, a polyphenol, a flavonoid, a carotenoid, a fatty acid, an oil, an enzyme, or a combination thereof. In some embodiments, the composition comprises one or more antioxidants. In some embodiments, the composition comprises one or more antioxidants selected from Vitamins (e.g., Vitamin E, Vitamin C), Polyphenols (e.g., Green Tea Extract, Grapeseed Extract), Flavonoids (e.g., Chamomile Extract), Carotenoids (e.g., Beta- Carotene), Fatty Acids and Oils (e.g., Argan Oil, Coconut Oil), Enzymes (e.g., Superoxide Dismutase), Ubiquinone (e.g., Coenzyme Q10), Ascorbic Acid (e.g., Vitamin C), and Ferulic Acid. In some embodiments, the composition comprises one or more antioxidants comprising Tocopheryl acetate, ascorbic acid, carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropin, Punica granatum bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, or nordihydroguaiaretic acid. In some embodiments, the composition comprises one or more antioxidants selected from a group that includes Tocopheryl acetate, ascorbic acid, carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropin, Punica granatum bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid. In some embodiments, the antioxidant comprises tocopherol. In some embodiments, the antioxidant comprises tocopheryl acetate. In some embodiments, the antioxidant comprises ascorbic acid. In some embodiments, the antioxidant comprises carnosine. In some embodiments, the antioxidant comprises tetrahexyldecyl ascorbate. In some embodiments, the antioxidant comprises bioflavonoids. In some embodiments, the antioxidant comprises lycopene. In some embodiments, the antioxidant comprises daucus carota sativa root cell culture lysate. In some embodiments, the antioxidant comprises monoammonium glycyrrhizinate. In some embodiments, the antioxidant comprises alpha-lipoic acid (thioctic acid). In some embodiments, the antioxidant comprises Leontopodium -97-WSGR Ref.63230-735.601 alpinum (edelweiss) extract. In some embodiments, the antioxidant comprises Rosmarinus officinalis (rosemary) leaf extract (WS). In some embodiments, the antioxidant comprises Vitis vinifera (grape) seed extract. In some embodiments, the antioxidant comprises Camellia sinensis leaf extract. In some embodiments, the antioxidant comprises Quercus robur wood extract. In some embodiments, the antioxidant comprises hydrolyzed olive fruit. In some embodiments, the antioxidant comprises Olea europea (olive) leaf extract. In some embodiments, the antioxidant comprises oleuropin. In some embodiments, the antioxidant comprises Punica granatum bark / fruit extract. In some embodiments, the antioxidant comprises punicalagin. In some embodiments, the antioxidant comprises ellagic acid. In some embodiments, the antioxidant comprises polyphenols. In some embodiments, the antioxidant comprises epigallocatechin (EGCG). In some embodiments, the antioxidant comprises tannins. In some embodiments, the antioxidant comprises sulforaphane. In some embodiments, the antioxidant comprises resveratrol. In some embodiments, the antioxidant comprises nordihydroguaiaretic acid. In some embodiments, the vitamin comprises tocopherol (Vitamin E), vitamin A, vitamin C, or a combination thereof.

[0193] In some embodiments, the antioxidant is present from about 0.0001% to about 5% total weight (%w / w) of a composition. In some embodiments, the antioxidant is present from about 0.001% to about 5% total weight of a composition. In some embodiments, the antioxidant is present from about 0.01% to about 5% total weight of a composition. In some embodiments, the antioxidant is present from about 0.1% to about 2% total weight of a composition. In some embodiments, the antioxidant is present from about 0.5% to about 2% total weight of a composition. In some embodiments, the antioxidant is present from about 0.5% to about 1.5% total weight of a composition. In some embodiments, the antioxidant is present from about 1% to about 5% total weight of a composition.

[0194] In some embodiments, the antioxidant is present (% w / w) up to about 0.05% total weight of a composition. In some embodiments, the antioxidant is present up to about 0.1% total weight of a composition. In some embodiments, the antioxidant is present up to about 0.5% total weight of a composition. In some embodiments, the antioxidant is present up to about 0.75% total weight of a composition. In some embodiments, the antioxidant is present up to about 1% total weight of a composition. In some embodiments, the antioxidant is present up to about 1.5% total weight of a composition. In some embodiments, the antioxidant is present up to about 2% total weight of a composition. In some embodiments, the antioxidant is present up to about 2.5% total weight of a composition. In some embodiments, the antioxidant is present up to about 3% total weight of a composition. In some embodiments, the antioxidant is present up to about 4% -98-WSGR Ref.63230-735.601 total weight of a composition. In some embodiments, the antioxidant is present up to about 5% total weight of a composition.

[0195] In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.005% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.01% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.5% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 2% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 5% (w / w) of a total weight of the composition.

[0196] In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.001% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.005% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.01% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.05% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.5% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 2% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 5% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 0.005% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition -99-WSGR Ref.63230-735.601 at a weight% of about 0.001% to about 0.01% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 0.05% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 0.1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 0.5% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 2% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 5% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 0.1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 0.5% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 2% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 5% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% to about 0.5% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% to about 1% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% to about 2% (w / w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% to about 5% (w / w) of a total weight of the composition.

[0197] In some embodiments, the composition comprises the formulation of Table 32, Table 33, Table 34, Table 35, or Table 36. Table 32-100-WSGR Ref.63230-735.601Table 33Table 34Table 35-101-WSGR Ref.63230-735.601 Table 36Cleansing Agents

[0198] In some embodiments, the composition described herein is a cleanser. In some embodiments, the composition described herein comprises a cleansing agent. In some embodiments, the composition further comprises a cleansing agent.

[0199] In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, and a cleansing agent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, and further comprises a cleansing agent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, and further comprises a cleansing agent.

[0200] In some embodiments, the cleansing agent helps to clean the hair. In some embodiments, the cleansing agent does not remove or replace any essential oils. Non-limiting example of a cleansing agent includes: an anionic surfactant, an amphoteric surfactant, a non- ionic surfactant, a biosurfactant, or any combinations thereof.

[0201] In order to be cosmetically acceptable, the surfactants may provide good foaming profiles and a stable rheology in addition to being efficient cleansers. Anionic surfactants tend to be top performers in these categories; however, consumer perception of the most efficient traditionally employed classes (i.e., sulfates) has made reception of these challenging. While this limits the selection of appropriate surfactants, it must also be noted that a further limiting factor is ion tolerance—as mentioned previously, many surfactants tend to be neutral or alkaline, but an acidic composition demands performance and stability at low pH and in potentially hard water. Sulfonates, in particular alkyl sulfonates or olefin sulfonates, exemplify one class that meets the specified criteria. These surfactants exhibit particularly good synergy with alpha hydroxyl acids or salicylic acid. -102-WSGR Ref.63230-735.601

[0202] However, single-surfactant systems often lack one aspect or another, and it is preferential to utilize a blend. Amphoteric surfactants impart gentleness and improve sensory profiles. Hydroxysultaines possess a remarkably low irritation profile and improve the mildness of surfactant compositions while boosting foam and stability, permitting lower total surfactant levels—another critical criterion in compositions meant to respect the skin barrier of the scalp. They also exhibit notably broad pH and electrolyte tolerance, making them excellent cleansers in hard water and in combination with acidic ingredients. Amino acid-derived surfactants can cleanse while simultaneously moisturizing skin or conditioning hair and are yet another exemplary choice. These surfactants may be used daily on the hair or skin when formulated appropriately. Finally, biosurfactants represent yet another type of high-performing cleanser molecule that holds the added benefit of superior environmental compatibility, be that more sustainable source materials, improved biodegradability, or greener manufacturing.

[0203] In some embodiments, the cleansing agent is a surfactant. In some embodiments, the surfactant comprises an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof.

[0204] In some embodiments, the cleansing agent comprises an anionic surfactant. In some embodiments, the cleansing agent is an anionic surfactant. Non-limiting example of an anionic surfactant includes: sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2- sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium C14- 16 alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucosides hydroxypropylsulfonate, disodium laurylglucosides hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside cross polymer, dioctyl sodium sulfosuccinate, or any combinations thereof. In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, -103-WSGR Ref.63230-735.601 sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof.

[0205] In some embodiments, the cleansing agent comprises an amphoteric surfactant. In some embodiments, the cleansing agent is an amphoteric surfactant. In some embodiments, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. In some embodiments, the cleansing agent comprises an amphoteric surfactant. In some embodiments, the cleansing agent is an amphoteric surfactant. Non-limiting example of an amphoteric surfactant includes cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, and any combinations thereof.

[0206] In some embodiments, the cleansing agent comprises a non-ionic surfactant. In some embodiments, the cleansing agent is a non-ionic surfactant. Non-limiting example of a non-ionic surfactant includes decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, and combinations thereof.

[0207] In some embodiments, the cleansing agent comprises a biosurfactant. In some embodiments, the cleansing agent is a biosurfactant. Non-limiting example of a biosurfactant includes Sapindus mukorossi (soapnut) extract, saponin, lipopeptide, canola sophorolipid, potassium cocoyl hydrolyzed oat protein, starmella bombicola / Brassica oil ferment, glycoside, glycolipid, rhamnolipid, phospholipid, sophorolipid, and any combinations thereof.

[0208] In some embodiments, the total concentration (%w / w) of the cleansing agent is about 5% (%w / w) to about 25% (%w / w). In some embodiments, the total concentration (%w / w) of the cleansing agent in the cleanser is about 0.1% to about 20.0%. In some embodiments, the concentration (%w / w) of the cleansing agent in a cleanser comprising one skin condition is about 0.1% to about 20.0%. In some embodiments, the concentration of each cleansing agent in a cleanser comprising two or more cleansing agent is at about 0.1% to about 20% In some embodiments, the concentration (%w / w) of the cleansing agent in the cleanser is about 0.1% to -104-WSGR Ref.63230-735.601 about 20%. In some embodiments, the concentration of the cleansing agent in the cleanser is about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, 0.7%, about 0.8%, about 0.9%, about 1.0%, about 1.2%, about 1.4%, about 1.6%, about 1.8%, about 2.0%, about 2.5%, about 3.0%, about 3.5%, about 4.0%, about 4.5%, about 5.0%, about 5.5%, about 6.0%, about 6.5%, about 7.0%, about 7.5%, about 8.0%, about 8.5%, about 9.0%, about 9.5%, about 10.0%, about 10.5%, about 11.0%, about 11.5%, about 12.0%, about 12.5%, about 13%, about 13.5%, about 14%, about 14.5%, about 15%, about 16%, about 17%, about 18%, about 19%, about 20%, and any values therebetween. In some embodiments, the concentration of the cleansing agent in the cleanser is about 0.1% to about 20%, about 0.2% to about 19%, about 0.3% to about 18%, about 0.4% to about 17%, about 0.5% to about 16%, about 0.6% to about 15%, about 0.7% to about 14.5%, about 0.8% to about 14%, about 0.9% to about 13.5%, about 1.0% to about 13%, about 1.5% to about 12.5%, about 2.0% to about 12%, about 2.5% to about 11.5%, about 3.0% to about 11%, about 3.5% to about 10.5%, and about 4% to about 10%. In some embodiments, the total concentration (%w / w) of the cleansing agent in the cleanser is about 0.01% (w / w) to about 20.0% (w / w) of a total weight of the cleanser.

[0209] In some embodiments, the concentration (%w / w) of the cleansing agent is the concentration of one or more surfactants, and the concentration of the cleansing agent in the cleanser is about 0.1% to about 30%. In some embodiments, the concentration (%w / w) of the cleansing agent in the cleanser is about 0.1% to about 30%. In some embodiments, the concentration (%w / w) of the cleansing agent in the cleanser is about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 5%, about 0.1% to about 10%, about 0.1% to about 15%, about 0.1% to about 18%, about 0.1% to about 20%, about 0.1% to about 23%, about 0.1% to about 25%, about 0.1% to about 28%, about 0.1% to about 30%, about 0.5% to about 1%, about 0.5% to about 5%, about 0.5% to about 10%, about 0.5% to about 15%, about 0.5% to about 18%, about 0.5% to about 20%, about 0.5% to about 23%, about 0.5% to about 25%, about 0.5% to about 28%, about 0.5% to about 30%, about 1% to about 5%, about 1% to about 10%, about 1% to about 15%, about 1% to about 18%, about 1% to about 20%, about 1% to about 23%, about 1% to about 25%, about 1% to about 28%, about 1% to about 30%, about 5% to about 10%, about 5% to about 15%, about 5% to about 18%, about 5% to about 20%, about 5% to about 23%, about 5% to about 25%, about 5% to about 28%, about 5% to about 30%, about 10% to about 15%, about 10% to about 18%, about 10% to about 20%, about 10% to about 23%, about 10% to about 25%, about 10% to about 28%, about 10% to about 30%, about 15% to about 18%, about 15% to about 20%, about 15% to about 23%, about 15% to about 25%, about 15% to about 28%, about 15% to about 30%, about 18% to about 20%, about 18% -105-WSGR Ref.63230-735.601 to about 23%, about 18% to about 25%, about 18% to about 28%, about 18% to about 30%, about 20% to about 23%, about 20% to about 25%, about 20% to about 28%, about 20% to about 30%, about 23% to about 25%, about 23% to about 28%, about 23% to about 30%, about 25% to about 28%, about 25% to about 30%, or about 28% to about 30%. In some embodiments, the concentration (%w / w) of the cleansing agent in the cleanser is about 0.1%, about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, about 28%, or about 30%. In some embodiments, the concentration (%w / w) of the cleansing agent is the concentration of a cleansing agent in the cleanser at between at least about 0.1%, about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, or about 28%. In some embodiments, the concentration (%w / w) of the cleansing agent in the cleanser is at most about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, about 28%, or at most about 30% of a total weight of the cleanser.

[0210] In some embodiments, the concentration (%w / w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants, which is present in the cleanser at about 0.1% to about 25% of a total weight of the cleanser. In some embodiments, the concentration (%w / w) of one surfactant or each of the one or more surfactants in the cleanser at about 0.1% to about 25%. In some embodiments, the concentration (%w / w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1% to about 0.2%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2%, about 0.1% to about 10%, about 0.1% to about 12%, about 0.1% to about 13%, about 0.1% to about 14%, about 0.1% to about 15%, about 0.1% to about 18%, about 0.1% to about 25%, about 0.2% to about 0.5%, about 0.2% to about 1%, about 0.2% to about 2%, about 0.2% to about 10%, about 0.2% to about 12%, about 0.2% to about 13%, about 0.2% to about 14%, about 0.2% to about 15%, about 0.2% to about 18%, about 0.2% to about 25%, about 0.5% to about 1%, about 0.5% to about 2%, about 0.5% to about 10%, about 0.5% to about 12%, about 0.5% to about 13%, about 0.5% to about 14%, about 0.5% to about 15%, about 0.5% to about 18%, about 0.5% to about 25%, about 1% to about 2%, about 1% to about 10%, about 1% to about 12%, about 1% to about 13%, about 1% to about 14%, about 1% to about 15%, about 1% to about 18%, about 1% to about 25%, about 2% to about 10%, about 2% to about 12%, about 2% to about 13%, about 2% to about 14%, about 2% to about 15%, about 2% to about 18%, about 2% to about 25%, about 10% to about 12%, about 10% to about 13%, about 10% to about 14%, about 10% to about 15%, about 10% to about 18%, about 10% to about 25%, about 12% to about 13%, about 12% to about 14%, about 12% to about 15%, about 12% to about 18%, about 12% to about 25%, about 13% to -106-WSGR Ref.63230-735.601 about 14%, about 13% to about 15%, about 13% to about 18%, about 13% to about 25%, about 14% to about 15%, about 14% to about 18%, about 14% to about 25%, about 15% to about 18%, about 15% to about 25%, or about 18% to about 25%. In some embodiments, the concentration (%w / w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1%, about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, about 18%, or about 25%. In some embodiments, the concentration (%w / w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at between at least about 0.1%, about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, or about 18%. In some embodiments, the concentration (%w / w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at between at most about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, about 18%, or about 25%. Film Forming Agents

[0211] In some embodiments, the composition described herein further comprises a film forming agent or a fixative. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a film forming agent or a fixative. In some embodiments, a conditioner composition comprises a film forming agent or a fixative.

[0212] Film forming agents or fixatives generally refer to and include, but are not limited to, ingredients that help maintain the fragrance in a product and on the hair for an extended period. In certain instances, film forming agents or fixatives work by slowing down the evaporation of the fragrance molecules, enhancing the longevity of the desired scent. In some embodiments, the composition further comprises a film forming agent or a fixative (e.g., a fixative polymer). In some embodiments, the composition comprises one or more film forming agents or fixatives. In some embodiments, the film forming agents comprises Acrylates / C10-30 Alkyl Acrylate Cross polymer, Polyvinylpyrrolidone (PVP) / acrylates cross polymer, PVP / acrylamide Cross polymer, Polyacrylamidomethylpropane sulfonic acid, octylacrylamide / acrylates / butyl-aminoethyl methacrylate copolymer, vinyl caprolactam / VP / dimethylaminoethyl methacrylate copolymer, and / or polyurethane-48.

[0213] In some embodiments, the film forming agents comprises Acrylates / C10-30 Alkyl Acrylate Cross polymer. In some embodiments, the film forming agent comprises PVP / acrylamide cross polymer. In some embodiments, the film forming agent comprises Polyvinylpyrrolidone (PVP) / acrylates cross polymer. In some embodiments, the film forming agent comprises polyacrylamidomethylpropane sulfonic acid. In some embodiments, the film -107-WSGR Ref.63230-735.601 forming agent comprises Octylacrylamide / Acrylates / Butylaminoethyl Methacrylate Copolymer. In some embodiments, the film forming agent comprises Vinyl Caprolactam / VP / Dimethylaminoethyl Methacrylate Copolymer. In some embodiments, the film forming agent comprises Polyurethane-48.

[0214] In some embodiments, the film forming agent is present from about 0.01% to about 2% (%w / w) total weight of a composition. In some embodiments, the film forming agent is present from about 0.1% to about 2% total weight of a composition. In some embodiments, the film forming agent is present from about 0.5% to about 2% total weight of a composition. In some embodiments, the film forming agent is present from about 0.5% to about 1.5% total weight of a composition.

[0215] In some embodiments, the film forming agent is present up to about 0.05% (%w / w) total weight of a composition. In some embodiments, the film forming agent is present up to about 0.1% total weight of a composition. In some embodiments, the film forming agent is present up to about 0.5% total weight of a composition. In some embodiments, the film forming agent is present up to about 0.75% total weight of a composition. In some embodiments, the film forming agent is present up to about 1% total weight of a composition. In some embodiments, the film forming agent is present up to about 1.5% total weight of a composition. In some embodiments, the film forming agent is present up to about 2% total weight of a composition. In some embodiments, the film forming agent is present up to about 2.5% total weight of a composition.

[0216] In some embodiments, the composition is as described in Table 37 or Table 38. Table 37Table 38-108-WSGR Ref.63230-735.601Humectants

[0217] In some embodiments, the composition comprises a humectant. In some embodiments, the humectant comprises glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof.

[0218] In some embodiments, the composition described herein further comprises a humectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a humectant. In some embodiments, a conditioner composition comprises a humectant.

[0219] Humectants generally refer to and include, but are not limited to, ingredients that attract and retain moisture, helping to keep the hair hydrated by preventing water loss. In certain instances, humectants draw moisture from the environment or deeper layers of the skin and hair, promoting improved moisture retention and overall hydration. In certain instances, humectants help maintain the hair's elasticity, softness, and manageability. Examples of humectants include but are not limited to glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, and hydrolyzed proteins. In some embodiments, the composition further comprises a humectant. In some embodiments, the humectant comprises glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof.

[0220] In some embodiments, the composition comprises a humectant. In some embodiments, the composition comprises one or more humectants. In some embodiments, the composition comprises one or more humectants selected from natural humectants such as glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, and hydrolyzed proteins. In some embodiments, the composition comprises a humectant comprising glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, dipropylene glycol, pentylene glycol, mannitol, -109-WSGR Ref.63230-735.601 trehalose, xylitol, inositol, acetamidoethoxyethanol, phytosteryl- / isostearyl- / cetyl- / stearyl- / behenyl-dimer dilinoleate, isopentyldiol, or a combination thereof. In some embodiments, the composition comprises a humectant selected from: Glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, dipropylene glycol, pentylene glycol, mannitol, trehalose, xylitol, inositol, acetamidoethoxyethanol, Phytosteryl- / Isostearyl- / Cetyl- / Stearyl- / Behenyl-Dimer Dilinoleate, Isopentyldiol, or a combination thereof. In some embodiments, the humectant comprises glycerin. In some embodiments, the humectant comprises butylene glycol. In some embodiments, the humectant comprises propylene glycol. In some embodiments, the humectant comprises propanediol. In some embodiments, the humectant comprises isopentyldiol. In some embodiments, the humectant comprises dipropylene glycol. In some embodiments, the humectant comprises pentylene glycol. In some embodiments, the humectant comprises mannitol. In some embodiments, the humectant comprises trehalose. In some embodiments, the humectant comprises xylitol. In some embodiments, the humectant comprises inositol. In some embodiments, the humectant comprises acetamidoethoxyethanol. In some embodiments, the humectant comprises phytosteryl- / isostearyl- / cetyl- / stearyl- / behenyl-dimer dilinoleate. In some embodiments, the humectant comprises Isopentyldiol. In some embodiments, the humectant comprises phytosteryl- / isostearyl- / cetyl- / stearyl- / behenyl-dimer dilinoleate, isopentyldiol, or both. In some embodiments, the humectant comprises hydrolyzed proteins. In some embodiments, the hydrolyzed proteins comprise hydrolyzed wheat starch. In some embodiments, the humectant comprises hydrolyzed wheat starch. In some embodiments, the humectant comprises urea, hydroxyethyl urea, polyols such as glycerin, and glycosaminoglycans (GAGS). In some instances, glycosaminoglycans comprise hyaluronic acid or hyaluronan (HA), heparan sulfate (HS), heparin (HP), chondroitin, chondroitin sulfate (CS), chondroitin 4-sulfate or chondroitin sulfate A (CSA), chondroitin 6-sulfate or chondroitin sulfate C (CSC), dermatan sulfate or chondroitin sulfate B (CSB) and keratan sulfate (KS).

[0221] In some embodiments, the humectant is present from 0.1% to 20% total weight of a composition. In some embodiments, the humectant is present from 0.5% to 10% total weight of a composition. In some embodiments, the humectant is present from 1% to 10% total weight of a composition. In some embodiments, the humectant other than water is present from 1% to 5% total weight of a composition.

[0222] In some embodiments, the humectant is present up to 0.1% total weight of a composition. In some embodiments, the humectant is present up to 0.5% total weight of a composition. In some embodiments, the humectant is present up to 1% total weight of a composition. In some embodiments, the humectant is present up to 2% total weight of a -110-WSGR Ref.63230-735.601 composition. In some embodiments, the humectant is present up to 3% total weight of a composition. In some embodiments, the humectant is present up to 5% total weight of a composition. In some embodiments, the humectant is present up to 6% total weight of a composition. In some embodiments, the humectant is present up to 10% total weight of a composition. In some embodiments, the humectant is present up to 15% total weight of a composition. In some embodiments, the humectant is present up to 20% total weight of a composition.

[0223] In certain embodiments, the conditioner composition comprises the formulation of Table 80. In certain embodiments, the conditioner composition comprises the formulation of Table 81 or Table 82. Table 80Table 81Table 82-111-WSGR Ref.63230-735.601Fatty Acids and Fatty Alcohols

[0224] In some embodiments, the composition described herein further comprises fatty acids or fatty alcohols. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises fatty acids or fatty alcohols. In some embodiments, a conditioner composition comprises fatty acids or fatty alcohols.

[0225] Fatty Acids and Fatty alcohols generally refer to and include, but are not limited to, ingredients found in hair compositions, and they serve various purposes to enhance the performance and benefits of the product (e.g., by having emollient, moisturizing, and / or conditioning properties). Examples of fatty acids include but are not limited to: oleic acid, linoleic acid, palmitic acid, stearic acid, and myristic acid. Examples of fatty alcohols include but are not limited to: cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, lauryl alcohol, or a combination thereof.

[0226] In some embodiments, the composition comprises a fatty acid. In some embodiments, the composition comprised one or more fatty acids. In some embodiments, the fatty acid comprises oleic acid, linoleic acid, palmitic acid, stearic acid, and myristic acid. In some embodiments, the composition comprise a fatty alcohol. In some embodiments, the composition comprises one or more fatty alcohols. In some embodiments, the fatty alcohol comprises cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, and lauryl alcohol. In some embodiments, the fatty acid and / or fatty alcohol comprises lauric acid, lauryl alcohol, palmitic acid, cetyl alcohol, stearic acid, stearyl alcohol, cetearyl alcohol, and / or behenyl alcohol, arachidic alcohol.

[0227] In some embodiments, the fatty acid or fatty alcohol is present from 0.1% to 20% total weight (% w / w) of a composition. In some embodiments, the fatty acid or fatty alcohol is present from 0.5% to 10% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present from 1% to 10% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol other than water is present from 1% to 5% total weight of a composition.

[0228] In some embodiments, the fatty acid or fatty alcohol is present up to 0.1% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 0.5% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 1% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 2% total weight of a composition. In some embodiments, the fatty acid or fatty -112-WSGR Ref.63230-735.601 alcohol is present up to 3% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 5% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 6% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 10% total weight of a composition. Waxes

[0229] In some embodiments, the composition described herein further comprises waxes. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises waxes. In some embodiments, a conditioner composition comprises waxes.

[0230] Waxes generally refer to and include, but are not limited to, lipophilic substances derived from natural sources or synthetic. Examples of waxes include but are not limited to: beeswax, candelilla wax, carnauba wax, microcrystalline wax, ozokerite, montan wax, polyethylene wax, paraffin wax, and synthetic waxes.

[0231] In some embodiments, the composition comprises a wax. In some embodiments, the wax comprises beeswax, candelilla wax, carnauba wax, microcrystalline wax, ozokerite, montan wax, polyethylene wax, paraffin wax, and synthetic waxes. I some embodiments, the wax comprises helianthus annuus (sunflower) seed wax and acacia decurrens flower wax.

[0232] In some embodiments, the wax is present from about 0.1% wt to about 20% wt of a total weight of a composition. In some embodiments, the wax is present from about 0.5% wt to about 10% wt of a total weight of a composition. In some embodiments, the wax is present from about 2% wt to about 12% wt of the total weight of a composition. In some embodiments, the wax is present from about 5% wt% to about 15% wt of the total weight of a composition.

[0233] In some embodiments, the wax is present from about 0.1% to about 10% total weight of a composition. In some embodiments, the wax is present from about 0.5% to about 5% total weight of a composition. In some embodiments, the wax is present from about 0.5% to about 2% total weight of a composition.

[0234] In some embodiments, the wax is present up to about 0.1% total weight of a composition. In some embodiments, the wax is present up to about 0.5% total weight of a composition. In some embodiments, the wax is present up to about 1% total weight of a composition. In some embodiments, the wax is present up to about 2.5% total weight of a composition. In some embodiments, the wax is present up to about 5% total weight of a composition. In some embodiments, the wax is present up to about 7.5% total weight of a composition. In some embodiments, the wax is present up to about 10% total weight of a composition. Pollution Protectants -113-WSGR Ref.63230-735.601

[0235] In some embodiments, the composition described herein further comprises pollution protectants. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises pollution protectants. In some embodiments, a conditioner composition comprises pollution protectants.

[0236] In some embodiments, the composition comprises a pollution protectant. In certain embodiments, the pollution protectant comprises an exopolysaccharide (EPSs). Exopolysaccharides generally refer to and include long-chain polysaccharides comprising repeating units of sugars, mainly glucose, galactose and rhamnose, in different ratios. In certain embodiments, the exopolysaccharides is obtained from Alteromonas Ferment Extract, Pseudoalteromonas Ferment Extract, green tea extract, or a combination thereof.

[0237] In certain embodiments, the conditioner composition comprises the formulation of Table 86. In certain embodiments, the conditioner composition comprises the formulation of Table 87 or Table 88. Table 86Table 87-114-WSGR Ref.63230-735.601Table 88Heat Protectants

[0238] In some embodiments, the composition described herein further comprises a heat protectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a heat protectant. In some embodiments, a conditioner composition comprises a heat protectant

[0239] Heat protectants generally refer to and include, but are not limited to, ingredients designed to shield the hair from damage caused by the application of heat (e.g., in heat styling tools such as flat irons, curling irons, and blow dryers). In certain instances, heat protectants create a protective barrier on the hair strands to minimize the negative effects of high temperatures. Examples of heat protectants include but are not limited to: dimethicone, amodimethicone, polyquaternium-4, polyquaternium-10, panthenol (Pro-Vitamin B5), cationic polymers like cetrimonium chloride or behentrimonium chloride, hydrolyzed proteins such as hydrolyzed wheat protein or hydrolyzed keratin, and quaternium-70. -115-WSGR Ref.63230-735.601

[0240] In certain embodiments, the composition comprises one or more heat protectants selected from: dimethicone, amodimethicone, polyquaternium-4, polyquaternium-10, panthenol (Pro-Vitamin B5), cationic polymers like cetrimonium chloride or behentrimonium chloride, hydrolyzed proteins such as hydrolyzed wheat protein or hydrolyzed keratin, and quaternium-70. In certain embodiments, the heat protectant comprises sodium methoxy peg-16 maleate / styrene sulfonate copolymer. In some embodiments, the heat protectant comprises panthenyl hydroxypropyl steardimonium chloride.

[0241] In some embodiments, the heat protectant is present from about 0.01% to about 2% total weight of a composition. In certain embodiments, the heat protectant is present from about 0.1% to about 2% total weight of a composition. In certain embodiments, the heat protectant is present from about 0.5% to about 2% total weight of a composition. In certain embodiments, the heat protectant is present from about 0.5% to about 1.5% total weight of a composition.

[0242] In certain embodiments, the heat protectant is present up to about 0.05% total weight of a composition. In certain embodiments, the heat protectant is present up to about 0.1% total weight of a composition. In certain embodiments, the heat protectant is present up to about 0.5% total weight of a composition. In certain embodiments, the heat protectant is present up to about 0.75% total weight of a composition. In certain embodiments, the heat protectant is present up to about 1% total weight of a composition. In certain embodiments, the heat protectant is present up to about 1.5% total weight of a composition. In certain embodiments, the heat protectant is present up to about 2% total weight of a composition. In certain embodiments, the heat protectant is present up to about 2.5% total weight of a composition. Detoxifying Agent

[0243] In some embodiments, the composition described herein is a cleanser. In some embodiments, the cleanser comprises a detoxifying agent. In some embodiments, the detoxifying agent can remove dirt, oil, sebum, or any product build-up from the hair or scalp. In some cases, the detoxifying agent may clean the scalp of dandruff, acne, or scabbing. In some cases, the detoxifying agent stimulates hair follicles to allow for hair growth. In some cases, the detoxifying agent reduces itchiness, oiliness, or inflammation. In some embodiments, the detoxifying agent comprises an absorbent. In some embodiments, the absorbent comprises charcoal such as a charcoal powder. In some embodiments, the one or more detoxifying agent comprises a zeolite. In some embodiments, the zeolite comprises kaolin clay, bentonite clay, French green clay, Brazilian clay, or a combination of two or more thereof. In some embodiments, the composition described herein comprises a polypeptide and a detoxifying -116-WSGR Ref.63230-735.601 agent. In some embodiments, the detoxifying agent comprises charcoal, bentonite, hectorite, or a combination thereof.

[0244] In some embodiments, the detoxifying agent comprises an absorbent such as charcoal. Charcoal can sequester metal ions at low levels without further complicating formulation with viscosity-altering chelating agents. Charcoal contains many small pores that create a large surface area capable of adsorbing heavy metals including iron (Fe), chromium (Cr), cadmium (Cd), and copper (Cu). Such adsorption of heavy metals can lead to detoxifying effect on the hair or scalp.

[0245] In some instances, the one or more detoxifying agents comprises a porous material comprising pores. In some instances, the pores enable absorption of dirt, oil, or buildup, or a combination or two or more thereof. In some instances, build up includes hair product build up. In some embodiments, the pores comprise an average diameter of about 0.1 μm to about 100 μm, about 0.2 μm to about 200 μm, about 0.3 μm to about 300 μm, about 0.4 μm to about 400 μm, about 0.5 μm to about 500 μm, about 0.6 μm to about 600 μm, about 0.7 μm to about 700 μm, about 0.8 μm to about 800 μm, about 0.9 μm to about 900 μm, about 1 μm to about 1000 μm, about 1 μm to about 100 μm, about 2 μm to about 200 μm, about 2 μm to about 300 μm, about 3 μm to about 400 μm, about 3 μm to about 500 μm, about 4 μm to about 600 μm, about 4 μm to about 700 μm, about 5 μm to about 800 μm, about 5 μm to about 900 μm, about 6 μm to about 1000 μm, about 0.1 μm to about 10 μm, about 0.1 μm to about 20 μm, about 0.1 μm to about 50 μm, about 0.1 μm to about 100 μm, about 0.1 μm to about 200 μm, about 0.1 μm to about 500 μm, about 0.1 μm to about 1000 μm, about 0.2 μm to about 10 μm, about 0.2 μm to about 20 μm, about 0.2 μm to about 50 μm, about 0.2 μm to about 100 μm, about 0.2 μm to about 200 μm, about 0.2 μm to about 500 μm, about 0.2 μm to about 1000 μm, about 0.5 μm to about 10 μm, about 0.5 μm to about 20 μm, about 0.5 μm to about 50 μm, about 0.5 μm to about 100 μm, about 0.5 μm to about 200 μm, about 0.5 μm to about 500 μm, about 0.5 μm to about 1000 μm, about 1 μm to about 20 μm, about 1 μm to about 50 μm, about 1 μm to about 100 μm, about 1 μm to about 200 μm, about 1 μm to about 500 μm, about 1 μm to about 1000 μm, about 2 μm to about 50 μm, about 2 μm to about 100 μm, about 2 μm to about 200 μm, about 2 μm to about 500 μm, about 2 μm to about 1000 μm, about 5 μm to about 100 μm, about 5 μm to about 200 μm, about 5 μm to about 500 μm, about 5 μm to about 1000 μm, about 10 μm to about 200 μm, about 10 μm to about 500 μm, or about 10 μm to about 1000 μm.

[0246] In some embodiments, the detoxifying agent comprises an average diameter of about 1 μm to about 100 μm, about 2 μm to about 200 μm, about 3 μm to about 300 μm, about 4 μm to about 400 μm, about 5 μm to about 500 μm, about 6 μm to about 600 μm, about 7 μm to about -117-WSGR Ref.63230-735.601 700 μm, about 8 μm to about 800 μm, about 9 μm to about 900 μm, about 10 μm to about 1000 μm, about 10 μm to about 100 μm, about 20 μm to about 200 μm, about 30 μm to about 300 μm, about 40 μm to about 400 μm, about 50 μm to about 500 μm, about 60 μm to about 600 μm, about 70 μm to about 700 μm, about 80 μm to about 800 μm, about 90 μm to about 900 μm, about 100 μm to about 1000 μm, about 1 μm to about 10 μm, about 1 μm to about 20 μm, about 1 μm to about 50 μm, about 1 μm to about 100 μm, about 1 μm to about 200 μm, about 1 μm to about 500 μm, about 1 μm to about 1000 μm, about 2 μm to about 10 μm, about 2 μm to about 20 μm, about 2 μm to about 50 μm, about 2 μm to about 100 μm, about 2 μm to about 200 μm, about 2 μm to about 500 μm, about 2 μm to about 1000 μm, about 5 μm to about 10 μm, about 5 μm to about 20 μm, about 5 μm to about 50 μm, about 5 μm to about 100 μm, about 5 μm to about 200 μm, about 5 μm to about 500 μm, about 5 μm to about 1000 μm, about 10 μm to about 20 μm, about 10 μm to about 50 μm, about 10 μm to about 100 μm, about 10 μm to about 200 μm, about 10 μm to about 500 μm, about 10 μm to about 1000 μm, about 20 μm to about 50 μm, about 20 μm to about 100 μm, about 20 μm to about 200 μm, about 20 μm to about 500 μm, about 20 μm to about 1000 μm, about 50 μm to about 100 μm, about 50 μm to about 200 μm, about 50 μm to about 500 μm, about 50 μm to about 1000 μm, about 100 μm to about 200 μm, about 100 μm to about 500 μm, or about 100 μm to about 1000 μm.

[0247] In some embodiments, the detoxifying agent is substantially monodispersed. In some embodiments, the detoxifying agent is substantially polydisperse.

[0248] In some embodiments, the detoxifying agent is present in the composition at about 0.01% (w / w) to about 5.0% (w / W), about 0.01% (w / w) to about 2.0% (w / w), or about 0.01% (w / w) to about 1.0% (w / w).

[0249] In some embodiments, the concentration (%w / w) of the detoxifying agent in the cleanser is about 0.01% to about 5.0% of a total weight of the cleanser. In some embodiments, the concentration of the detoxifying agent in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 2.0%, about 2.0%, about 2.1%, about 2.2%, about 2.3%, about 2.4%, about 2.5%, about 2.6%, about 2.7%, about 2.8%, about 2.9%, about 3.0%, about 3.1%, about 3.2%, about 3.3%, about 3.4%, about 3.5%, about 3.6%, about 3.7%, about 3.8%, about 3.9%, about 4.0%, about 4.1%, about 4.2%, about 4.3%, about 4.4%, about 4.5%, about 4.6%, about 4.7%, about 4.8%, about 4.9%, or about 5.0%, and any values therebetween of a total weight of the cleanser. In some embodiments, the concentration of the detoxifying agent in the cleanser is about 0.01% to about 0.95%, about -118-WSGR Ref.63230-735.601 0.05% to about 1.0%, about 0.20% to about 0.90%, about 0.30% to about 0.85%, about 0.40% to about 0.80%, about 0.50% to about 0.75%, about 0.60% to about 0.70%, and about 0.70% to about 5.0% of a total weight of the cleanser. Hair Conditioner

[0250] In some embodiments, the composition described herein is a cleanser. In some embodiments, the composition described herein comprises a hair conditioner. In some embodiments, the composition further comprises a hair conditioner. In some embodiments, the composition described herein comprises a polypeptide and a hair conditioner.

[0251] In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, and further comprises a hair conditioner.

[0252] In some embodiments, the cleanser described herein comprises a hair conditioner which may repair and / or improve the properties of hair, such as elasticity, resistance, texture (i.e., softness, smoothness, etc.), and / or appearance. Non-limiting example of hair conditioner includes panthenol, salicylic acid, sodium salicylate, carnosine, tetrahexyldecyl ascorbate, hyaluronic acid / sodium hyaluronate, hydrolyzed hyaluronic acid, sarcosine, PCA, arginine PCA,, brassicyl valinate esylate, brassicyl isoleucinate esylate, brassica alcohol, glycolipids, glycosphingolipids, sphinganine, Rubus ideaus (raspberry) leaf extract, bis- ethyl(isostearylimidazoline) isostearamide, Camellia sinensis leaf extract, Carthamus tinctorius (safflower) seed extract, Glycine soja (soybean) seed extract, Elaeis guineensis (palm) fruit extract, Oryza sativa (rice) extract, hydrolyzed Adansonia digitata seed extract, hydrolyzed corn starch, behenyl / stearyl aminopropanediol esters, C10-40 isoalkylamidopropylethyldimonium ethosulfate, Linum usitatissimum (linseed) extract, Salva hispanica seed extract, Astrocaryum mururmuru fruit extract, Moringa oleifera seed extract, cinnamidopropyltrimonium chloride, hydroxypropyl guar hydroxypropyltrimonium chloride, Trifolium pratense (clover) flower extract, Opuntia ficus-indica stem extract, Kappaphycus alvarezii extract, Laminaria saccharina extract, guar hydroxypropyltriammonium chloride, bis-diglyceryl polyacyladipate-2, hydroxypropylgluconamide, hydroxypropylammonium gluconate, biosaccharide gum-4, prunus Amygdalus dulcic (sweet almond) seed extract, soybean glycerides, Butyrospermum parkii (shea) butter unsaponifiables, hydrolyzed chestnut extract, glyceryl rosinate, sodium methoxy PEG-16 maleate / styrene sulfonate copolymer, panthenyl hydroxypropyl steardimonium chloride, and any combinations thereof. In some embodiments, the hair conditioner comprises panthenol, salicylic acid, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. -119-WSGR Ref.63230-735.601

[0253] In some embodiments, the total concentration (%w / w) of the hair conditioner in the cleanser is about 0.01% to about 10.0%. In some embodiments, the concentration (%w / w) of the hair conditioner in the cleanser is about 0.01% to about 10.0%. In some embodiments, the concentration of each hair conditioner in the cleanser comprising two or more hair conditioners is at about 0.01% to about 10%. In some embodiments, the total concentration of hair conditioner in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.7%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, and any values therebetween. In some embodiments, the concentration of each hair conditioner in the cleanser is about 0.01% to about 10%, about 0.05% to about 9.5%, about 0.20% to about 9%, about 0.30% to about 8.5%, about 0.40% to about 8%, about 0.50% to about 7.5%, about 0.60% to about 7%, about 0.70% to about 6.5%, about 0.80% to about 6%, about 0.90% to about 5.5%, and about 1% to about 5%.

[0254] In some embodiments, the hair conditioner is present in the composition at about 0.01% (%w / w) to about 10% (%w / w). In some embodiments, the hair conditioner is present in the composition at about 0.01% (w / w), about 0.05% (w / w), about 0.10% (w / w), about 0.15% (w / w), about 0.20% (w / w), about 0.25% (w / w), about 0.30% (w / w), about 0.35% (w / w), about 0.40% (w / w), about 0.45% (w / w), about 0.50% (w / w), about 0.55% (w / w), about 0.60% (w / w), about 0.65% (w / w), about 0.70% (w / w), about 0.75% (w / w), about 0.80% (w / w), about 0.85% (w / w), about 0.90% (w / w), about 0.95% (w / w), about 1.0% (w / w), about 1.5% (w / w), about 2% (w / w), about 2.5% (w / w), about 3% (w / w), about 3.5% (w / w), about 4% (w / w), about 4.5% (w / w), about 5% (w / w), about 5.5% (w / w), about 6% (w / w), about 6.5% (w / w), about 7% (w / w), about 7.5% (w / w), about 8% (w / w), about 8.5% (w / w), about 9% (w / w), about 9.5% (w / w), about 10% (w / w), or any values therebetween. In some embodiments, the hair conditioner is present in the composition at about 0.01% (w / w) to about 10% (w / w), about 0.05% (w / w) to about 9.5% (w / w), about 0.20% (w / w) to about 9% (w / w), about 0.30% (w / w) to about 8.5% (w / w), about 0.40% (w / w) to about 8% (w / w), about 0.50% (w / w) to about 7.5% (w / w), about 0.60% (w / w) to about 7% (w / w), about 0.70% (w / w) to about 6.5% (w / w), about 0.80% (w / w) to about 6% (w / w), about 0.90% (w / w) to about 5.5% (w / w), or about 1% (w / w) to about 5% (w / w). Skin Conditioner -120-WSGR Ref.63230-735.601

[0255] In some embodiments, the composition described herein is a cleanser. In some embodiments, the composition described herein comprises a skin conditioner (or a skin conditioning agent). In some embodiments, the composition comprises a cleansing agent and a skin conditioner. In some embodiments, the composition comprises a detoxifying agent and a skin conditioner.

[0256] In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, and a skin conditioner. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, and further comprises a skin conditioner. In some embodiments, the composition comprises a polypeptide, a cleansing agent, a hair conditioner, and a skin conditioner.

[0257] In some embodiments, the skin conditioner may support the skin’s barrier function and / or help retain moisture. Non-limiting example of a skin conditioner can include niacinamide, allantoin, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus- indica stem extract, sodium hyaluronate cross polymer, jojoba esters, hydrolyzed jojoba esters, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid / sodium ursolate, nordihydroguaiaretic acid, ceramides, fructooligosaccharides, galactoarabinan, schizophyllan, Anetholea anisate leaf extract, Tetraselmis suecica extract, saccharide isomerase, Alteromonas ferment extract, Pseudoalteromonas ferment extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Betula alba juice, Saccharum officinarum (sugarcane) extract, Rhodomyrtus tomentosa fruit extract, Hedychium coronarium root extract, Epilobium angustifolium flower / leaf / stem extract, Tremella fuciformis sporocarp extract, alpha-glucan oligosaccharide, and any combinations thereof.

[0258] In some embodiments, the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof.

[0259] In some embodiments, the total concentration (%w / w) of the skin conditioner in the cleanser is about 0.01% to about 10.0%, about 0.01% to about 8.0%, or about 0.01% to about 5%. In some embodiments, the concentration (%w / w) of the skin conditioner in a cleanser comprising one skin condition is about 0.01% to about 10.0%. In some embodiments, the concentration of each skin conditioner in a cleanser comprising two or more skin conditioner is at about 0.01% to about 10%. In some embodiments, the concentration of the skin conditioner in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about -121-WSGR Ref.63230-735.601 0.60%, about 0.65%, about 0.7%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, and any values therebetween. In some embodiments, the concentration of the skin conditioner in the cleanser is about 0.01% to about 10%, about 0.05% to about 9.5%, about 0.20% to about 9%, about 0.30% to about 8.5%, about 0.40% to about 8%, about 0.50% to about 7.5%, about 0.60% to about 7%, about 0.70% to about 6.5%, about 0.80% to about 6%, about 0.90% to about 5.5%, and about 1% to about 5%. Additional Agents

[0260] In some embodiments, the composition comprises an additional agent. In some embodiments, the composition described herein further comprises an additional agent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an additional agent. In some embodiments, a conditioner composition comprises an additional agent.

[0261] In some embodiments, the composition comprises one or more additional agents. In some embodiments, the additional agent comprises a conditioning and emollient blend, additional hair-conditioning agents, film-forming agents, skin-conditioning agents, moisturizing agents, additional UV absorbers, viscosity-controlling agents, and additional fixatives. These include but are not limited to ingredients such as Brassica Alcohol, Brassicyl Valinate Esylate, Brassicyl Isoleucinate Esylate, Bis-Ethyl(Isostearylimidazoline) Isostearamide, Sarcosine, Arginine PCA, Glycolipids, Glycosphingolipids, Panthenol, Carthamus Tinctorius (Safflower) Seed Extract, Polysilicone-29, Sphinganine, Phytantriol, Hydrolyzed Adansonia Digitata Seed Extract, Hydrolyzed Quinoa, Hydrolyzed Rice Protein, Hydrolyzed Soy Protein, Hydrolyzed Vegetable Protein, Hydrolyzed Corn Starch, Behenyl / Stearyl Aminopropanediol Esters, Cystine Bis-PG-Propyl Silanetriol, Polyquaternium-57, Polyquaternium-59, Polyimide-1, Polyurethane- 35, PVM / MA Copolymer, Dicetyldimonium Chloride, Stearamidopropyl Dimethylamine, C10- 40 Isoalkylamidopropylethyldimonium Ethosulfate, SH-Polypeptide-3, Linum Usitatissimum (Linseed) Extract, Salvia Hispanica Seed Extract, Astrocaryum Murumuru Fruit Extract, Orbignya Speciosa Kernel Oil, Moringa Oleifera Seed Extract, Cinnamidopropyltrimonium Chloride, Octylacrylamide / Acrylates / Butyl-aminoethyl Methacrylate Copolymer, Hydroxypropyl Guar Hydroxypropyltrimonium Chloride, Bis-4-PCA Dimethicone, Hydrolyzed Vegetable Protein PG-Propyl Silanetriol, Trifolium Pratense (Clover) Flower Extract, Opuntia Ficus-Indica Stem Extract, Camellia Sinensis Leaf Extract, Kappaphycus Alvarezii Extract, Laminaria Saccharina Extract, Ceramides, Creatine, Hydrogenated Castor Oil / Sebacic Acid -122-WSGR Ref.63230-735.601 Copolymer, Bis-Diglyceryl Polyacyladipate-2, Hydroxypropylgluconamide, Hydroxypropylammonium Gluconate, Biosaccharide Gum-4, Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract, [Glycine Soja (Soybean) Seed Extract, Elaeis Guineensis (Palm) Fruit Extract, Oryza Sativa (Rice) Extract], Soybean Glycerides, Butyrospermum Parkii (Shea) Butter Unsaponifiables, Hydrolyzed Chestnut Extract, Glyceryl Rosinate, and Shorea Robusta Resin.

[0262] In some embodiments, the composition comprises an additional agent comprising Brassica alcohol, brassicyl valinate esylate, brassicyl isoleucinate esylate, bis- ethyl(isostearylimidazoline) isostearamide, sarcosine, Arginine PCA, glycolipids, glycosphingolipids, panthenol, Carthamus tinctorius (safflower) seed extract, polysilicone-29, sphinganine, phytantriol, hydrolyzed adansonia digitata seed extract, hydrolyzed quinoa, hydrolyzed rice protein, hydrolyzed soy protein, hydrolyzed vegetable protein, hydrolyzed corn starch, behenyl / stearyl aminopropanediol esters, cystine bis-pg-propyl silanetriol, polyquaternium-57, polyquaternium-59, polyimide-1, polyurethane-35, PVM / MA copolymer, dicetyldimonium chloride, stearamidopropyl dimethylamine, C10-40 isoalkylamidopropylethyldimonium ethosulfate, sh-polypeptide-3, linum usitatissimum (linseed) extract, salva hispanica seed extract, astrocaryum mururmuru fruit extract, orbigyna speciosa kernel oil, moringa oleifera seed extract, cinnamidopropyltrimonium chloride, octylacrylamide / acrylates / butylaminoethyl methacrylate copolymer, hydroxypropyl guar hydroxypropyltrimonium chloride, bis-4-PCA dimethicone, hydrolyzed vegetable protein PG- propyl silanetriol, trifolium pratense (clover) flower extract, opuntia ficus-indica stem extract, camellia sinensis leaf extract, kappaphycus alvarezii extract, laminaria saccharina extract, ceramides, creatine, hydrogenated castor oil / sebacic acid copolymer, bis-diglyceryl polyacyladipate-2, hydroxypropylgluconamide, hydroxypropylammonium gluconate, biosaccharide gum-4, prunus amygdalus dulcic (sweet almond) seed extract, [glycine soja (soybean) seed extract, Elaeis Guineensis (palm) fruit extract, oryza sativa (rice) extract, soybean glycerides, butyrospermum parkii (shea) butter unsaponifiables, hydrolyzed chestnut extract, glyceryl rosinate, and / or shorea robusta resin.

[0263] In some embodiments, the additional agent comprises Brassica alcohol. In some embodiments, the additional agent comprises Brassicyl valinate esylate. In some embodiments, the additional agent comprises Brassicyl isoleucinate esylate. In some embodiments, the additional agent comprises Bis-ethyl(isostearylimidazoline) isostearamide. In some embodiments, the additional agent comprises Sarcosine. In some embodiments, the additional agent comprises Arginine PCA. In some embodiments, the additional agent comprises Glycolipids. In some embodiments, the additional agent comprises Glycosphingolipids. In some -123-WSGR Ref.63230-735.601 embodiments, the additional agent comprises Panthenol. In some embodiments, the additional agent comprises Carthamus tinctorius (safflower) seed extract. In some embodiments, the additional agent comprises Polysilicone-29. In some embodiments, the additional agent comprises Sphinganine. In some embodiments, the additional agent comprises Phytantriol. In some embodiments, the additional agent comprises Hydrolyzed Adansonia digitata seed extract. In some embodiments, the additional agent comprises Hydrolyzed Quinoa. In some embodiments, the additional agent comprises Hydrolyzed Rice Protein. In some embodiments, the additional agent comprises Hydrolyzed Soy Protein. In some embodiments, the additional agent comprises Hydrolyzed Vegetable Protein. In some embodiments, the additional agent comprises Hydrolyzed Corn Starch. In some embodiments, the additional agent comprises Behenyl / Stearyl Aminopropanediol Esters. In some embodiments, the additional agent comprises Cystine bis-PG-Propyl Silanetriol. In some embodiments, the additional agent comprises Polyquaternium-57. In some embodiments, the additional agent comprises Polyquaternium-59. In some embodiments, the additional agent comprises Polyimide-1. In some embodiments, the additional agent comprises Polyurethane-35. In some embodiments, the additional agent comprises PVM / MA Copolymer. In some embodiments, the additional agent comprises Dicetyldimonium Chloride. In some embodiments, the additional agent comprises Stearamidopropyl Dimethylamine. In some embodiments, the additional agent comprises C10- 40 Isoalkylamidopropylethyldimonium Ethosulfate. In some embodiments, the additional agent comprises SH-Polypeptide-3. In some embodiments, the additional agent comprises Linum usitatissimum (linseed) extract. In some embodiments, the additional agent comprises Salvia hispanica seed extract. In some embodiments, the additional agent comprises Astrocaryum murumuru fruit extract. In some embodiments, the additional agent comprises Orbignya speciosa kernel oil. In some embodiments, the additional agent comprises Moringa oleifera seed extract. In some embodiments, the additional agent comprises Cinnamidopropyltrimonium Chloride. In some embodiments, the additional agent comprises Octylacrylamide / Acrylates / Butylaminoethyl Methacrylate Copolymer. In some embodiments, the additional agent comprises Hydroxypropyl Guar Hydroxypropyltrimonium Chloride. In some embodiments, the additional agent comprises Bis-4-PCA Dimethicone. In some embodiments, the additional agent comprises Hydrolyzed Vegetable Protein PG-Propyl Silanetriol. In some embodiments, the additional agent comprises Trifolium pratense (clover) flower extract. In some embodiments, the additional agent comprises Opuntia ficus-indica stem extract. In some embodiments, the additional agent comprises Camellia sinensis leaf extract. In some embodiments, the additional agent comprises Kappaphycus alvarezii extract. In some -124-WSGR Ref.63230-735.601 embodiments, the additional agent comprises Laminaria saccharina extract. In some embodiments, the additional agent comprises Ceramides. In some embodiments, the additional agent comprises Creatine. In some embodiments, the additional agent comprises Hydrogenated Castor Oil / Sebacic Acid Copolymer. In some embodiments, the additional agent comprises Bis- Diglyceryl Polyacyladipate-2. In some embodiments, the additional agent comprises Hydroxypropylgluconamide. In some embodiments, the additional agent comprises Hydroxypropylammonium Gluconate. In some embodiments, the additional agent comprises Biosaccharide Gum-4. In some embodiments, the additional agent comprises Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract. In some embodiments, the additional agent comprises one or more extracts comprising Glycine soja (Soybean) Seed Extract, Elaeis Guineensis (Palm) Fruit Extract, Oryza Sativa (Rice) Extract, and / or Soybean Glycerides. In some embodiments, the additional agent comprises Butyrospermum Parkii (Shea) Butter Unsaponifiables. In some embodiments, the additional agent comprises Hydrolyzed Chestnut Extract. In some embodiments, the additional agent comprises Glyceryl Rosinate. In some embodiments, the additional agent comprises Shorea Robusta Resin.

[0264] In some embodiments, the additional agent comprises a cosmetically or dermatologically acceptable excipient comprising a fragrance comprising a perfume or perfuming ingredient. In some embodiments, the cosmetically or dermatologically acceptable excipient is a perfuming ingredient. A non-limiting example of a perfuming ingredient includes limonene. In some embodiments, the fragrance comprises limonene, hydroxycitronellol, benzyl dalicylate, or hexyl cinnamal, or a combination of two or more thereof.

[0265] In some embodiments, the composition described herein is a cleanser. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a cleansing agent, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient or an additional agent.

[0266] In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, and further comprises an excipient or an additional agent. In some embodiments, the -125-WSGR Ref.63230-735.601 composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, and further comprises an excipient or an additional agent.

[0267] In some instances, the excipient or the additional agent comprises a humectant, a chelating agent, a buffer, a preservative, or a combination of two or more thereof.

[0268] In some embodiments, the cleanser described herein comprises a cosmetically or dermatologically acceptable excipient. Non-limiting examples of the cosmetically or dermatologically acceptable excipient include preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreen agents, vitamins, dyes, hair coloring agents, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, perfumes, oils, emollients, lubricants, butters, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film formers, surfactants, detergents, emulsifiers, opacifying agents, volatiles, propellants, liquid vehicles, carriers, salts, pH modifiers (used interchangeably with buffering agent or buffer), neutralizing agents, buffers, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, absorbents, or any combinations thereof

[0269] In some embodiments, the excipient comprises a humectant, a chelating agent, a buffer, a preservative, or a combination thereof.

[0270] In some embodiments, the excipient is present in the composition at about 0.1% (%w / w) to about 30% (%w / w). In some embodiments, the total concentration (%w / w) of the cosmetically or dermatologically acceptable excipient in the cleanser is about 0.1% to about 30%. In some embodiments, the concentration (%w / w) of the cosmetically or dermatologically acceptable excipient in a cleanser comprising one skin condition is about 0.1% to about 30%. In some embodiments, the concentration of each cosmetically or dermatologically acceptable excipient in a cleanser comprising two or more cosmetically or dermatologically acceptable excipient is at about 0.1% to about 30%. In some embodiments, the concentration of the cosmetically or dermatologically acceptable excipient in the cleanser is about 0.1%, about 0.5%, about 1.0%, about 2.0%, about 3.0%, about 4.0%, about 5.0%, about 6.0%, about 7.0%, about 8.0%, about 9.0%, about 10.0%, about 11.0%, about 12.0%, about 13.0%, about 14.0%, about 15.0%, about 16.0%, about 17.0%, about 18.0%, about 19.0%, about 20.0%, about 21.0%, about 22.0%, about 23.0%, about 24.0%, about 25.0%, about 26.0%, about 27.0%, about 28.0%, about 29.0%, about 30.0%, and any values therebetween. In some embodiments, the concentration of the cosmetically or dermatologically acceptable excipient in the cleanser is about 0.1% to about 29.0%, about 0.5% to about 28.0%, about 1.0% to about 27.0%, about 2.0% to about 26.0%, about 3.0% to about 25.0%, about 4.0% to about 24.0%, about 5.0% to about 23.0%, about 6.0% to about 22.0%, about 7.0% to about 21.0%, about 8.0% to about 20.0%, about 9.0% to about -126-WSGR Ref.63230-735.601 19.0%, about 10.0% to about 18.0%, about 11.0% to about 17.0%, about 12.0% to about 16.0%, about 13.0% to about 15.0%, about 14.0% to about 14.5%, and about 14.5% to about 30.0%.

[0271] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an emulsifier. In some embodiments, the cosmetically or dermatologically acceptable excipient is an emulsifier. Non-limiting example of an emulsifier includes caprylic / capric / diglyceryl succinate, C14-16 glycol palmitate, C18-20 glycol isostearate, cocamidopropyl lauryl ether, dipentaerythrityl hydroxystearate, dipentaerythrityl hydroxyisostearate, dipentaerythrityl hexacaprate / caprylate, palm kernel glycerides, lecithin, hydrogenated lecithin, phosphatidylcholine, C12-16 alcohols, palmitic acid, glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, glyceryl stearate citrate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate / stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl- 6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla / jojoba / rice bran polyglyceryl-3 esters, stearoyl glutamic acid, Polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or any combinations thereof.

[0272] In some embodiments, the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. In some embodiments, the humectant is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w). In some embodiments, the humectant is present in the composition from about 0.001% (%w / w) to about 5% (%w / w), from about 0.001% (%w / w) to about 3% (%w / w), from about 0.001% (%w / w) to about 2% (%w / w), from about 0.001% (%w / w) to about 1% (%w / w), from about 0.001% (%w / w) to about 0.5% (%w / w), from about 0.01% (%w / w) to about 5% (%w / w), from about 0.01% (%w / w) to about 3% (%w / w), from about 0.01% (%w / w) to about 2% (%w / w), from about 0.01% (%w / w) to about 1% (%w / w), or from about 0.01% (%w / w) to about 0.05% (%w / w).

[0273] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a chelating agent. In some embodiments, the cosmetically or dermatologically -127-WSGR Ref.63230-735.601 acceptable excipient is a chelating agent. Non-limiting example of a chelating agent includes phytic acid, sodium phytate, caprylhydroxamic acid, trisodium dicarboxymethyl alaninate, gluconic acid, sodium gluconate, pentasodium pentetate, sodium carboxymethyl inulin, tetrasodium glutamate diacetate, trisodium ethylenediamine succinate, sodium thiosulfate, diiospropyl oxalate, disodium EDTA, disodium EDTA-copper, HEDTA, oxalic acid, potassium citrate, sodium citrate, sodium oxalate, TEA-EDTA, tetrasodium EDTA, trisodium EDTA, trisodium HEDTA, or any combinations thereof. In some embodiments, the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. IN some embodiments, chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. In some embodiments, the chelating agent is present in the composition at about 0.001% (%w / w) to about 2% (%w / w), about 0.001% to about 1% (%w / w), about 0.01% (%w / w) to about 1% (%w / w), or about 0.01% (%w / w) to about 0.5% (%w / w).

[0274] In some embodiments, the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. In some embodiments, the buffer is present in the composition at about 0.001% (%w / w) to about 2% (%w / w), about 0.001% to about 1% (%w / w), about 0.01% (%w / w) to about 1% (%w / w), or about 0.01% (%w / w) to about 0.5% (%w / w).

[0275] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a preservative. In some embodiments, the cosmetically or dermatologically acceptable excipient is a preservative. Non-limiting example of a preservative includes benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or any combinations thereof. In some embodiments, the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. In some embodiments, the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. In some embodiments, the preservative is present in the composition at about 0.001% (%w / w) to about 1% (%w / w), about 0.01% (%w / w) to about 1% (%w / w), or about 0.01% (%w / w) to about 0.1% (%w / w). -128-WSGR Ref.63230-735.601

[0276] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a thickener. In some embodiments, the cosmetically or dermatologically acceptable excipient is a thickener. Non-limiting example of a thickener includes lauryl lactate, hydroxypropyl starch phosphate, acrylates copolymer, ammonium acryloyldimethyltaurate, sodium acryloyldimethyltaurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, polyacrylate cross polymer-11, carbomer, acrylates / C10-30 alkyl acrylate cross polymer, hydroxyethyl acrylate / sodiumacryloyldimethyltaurate copolymer, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, glycol distearate, hydrogenated castor oil, hydrogenated castor oil hydroxystearate, hydrogenated castor oil isostearate, hydrogenated castor oil stearate, hydrogenated castor PEG-8 esters, or any combinations thereof.

[0277] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an anti-static agent. In some embodiments, the cosmetically or dermatologically acceptable excipient is an anti-static agent. In some embodiments, the anti-static agent is a cationic surfactant. Non-limiting example of an anti-static agent includes quaternary ammonium compounds, behentrimonium chloride, behentrimonium methosulfate, cetrimonium chloride, cetrimonium methosulfate, benzalkonium chloride, benzethonium chloride, cinnamidopropyltrimonium chloride, cocotrimonium chloride, dicetyldimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, steartrimonium chloride, stearalkonium chloride, tricetyldimonium chloride, PCA ethyl cocoyl arginate, C10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butteramidopropyltrimonium chloride, or any combinations thereof.

[0278] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a naturally derived polymer. In some embodiments, the cosmetically or dermatologically acceptable excipient is a naturally derived polymer. Non-limiting example of a naturally derived polymer includes xanthan gum, pullulan, algin, tetragonoloba (guar) gum, sclerotium gum, acacia Senegal gum, cellulose, cellulose gum, carboxymethylcellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, lauryl polyglucose, and any combinations thereof. -129-WSGR Ref.63230-735.601

[0279] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an amino acid such as L-Cysteine. In some embodiments, the cosmetically or dermatologically acceptable excipient is an amino acid such as L-Cysteine.

[0280] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a humectant. In some embodiments, the cosmetically or dermatologically acceptable excipient is a humectant. Non-limiting example of a humectant includes 1,2,6 hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyldiol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, inositol, erythritol, capryl glycol, acetamidoethoxyethanol, or any combinations thereof.

[0281] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a cationic polymer. In some embodiments, the cosmetically or dermatologically acceptable excipient is a cationic polymer. Non-limiting example of a cationic polymer includes polyquaternium-10, polyquaternium-7, polyquaternium-11, polyquaternium-57, quaternium-15, quaternium-18, quaternium-22, quaternium-87, guar hydroxypropyltrimonium chloride, or any combinations thereof.

[0282] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a non-ionic surfactant. In some embodiments, the cosmetically or dermatologically acceptable excipient is a non-ionic surfactant. Non-limiting example of a non-ionic surfactant includes decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, and combinations thereof. In some embodiments, the non-ionic surfactant is a solubilizer, emulsifier, stabilizer, emollient, thickener, or any combinations thereof.

[0283] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a silicone. In some embodiments, the cosmetically or dermatologically acceptable excipient is a silicone. Non-limiting example of a silicone includes amodimethicone, amodimethicone, dimethicone cyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol, dimethiconol, hydrolyzed wheat protein hydroxypropyl polysiloxane, trimethylsilylamodimethicone, or any combinations thereof.

[0284] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a protein. In some embodiments, the cosmetically or dermatologically acceptable excipient is a protein. Non-limiting example of a protein includes cocodimonium hydroxypropyl -130-WSGR Ref.63230-735.601 hydrolyzed casein, cocodimonium hydroxypropyl hydrolyzed collagen, cocodimonium hydroxypropyl hydrolyzed hair keratin, cocodimonium hydroxypropyl hydrolyzed keratin, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed silk, cocodimonium hydroxypropyl hydrolyzed soy protein, cocodimonium hydroxypropyl hydrolyzed wheat protein, cocodimonium hydroxypropyl silk amino acids, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, hydrolyzed keratin, hydrolyzed oat flour, hydrolyzed silk, hydrolyzed silk protein, hydrolyzed soy protein, hydrolyzed wheat protein, hydrolyzed quinoa, hydrolyzed elastin, hydrolyzed collagen, keratin, potassium cocoyl hydrolyzed collagen, or any combinations thereof.

[0285] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a vitamin. In some embodiments, the cosmetically or dermatologically acceptable excipient is a vitamin. Non-limiting example of a vitamin includes retinol, retinyl palmitate, ascorbic acid, tocopherol, tocopherol acetate, or any combinations thereof.

[0286] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a natural extract. In some embodiments, the cosmetically or dermatologically acceptable excipient is a natural extract. Non-limiting example of a natural extract includes Aloe barbadensis leaf extract, Yucca schidigera leaf extract, Yucca schidigera root extract, Camellia sinensis leaf extract, Equisetum arvense leaf extract, Hamamelis virginiana leaf extract, Macrocystis pyrifera kelp extract, or combinations thereof.

[0287] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an emollient. In some embodiments, the cosmetically or dermatologically acceptable excipient is an emollient. Non-limiting example of an emollient includes isopropyl lauroyl sarcosinate, phenethyl benzoate, C12-15 alkyl benzoate, caprylic / capric triglyceride, cetyl octanoate, octyldodecanol, dilinoleic acid / propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin / sebacic acid copolymer, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil / IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate / dicaprate (dispersant), propylene glycol dicaprylate / dicaprate, triolein (algae oil), propylene glycol dicaprylate / dicaprate, phytosteryl / octyldodecyl lauroyl glutamate, C10-18 triglycerides, isostearyl alcohol, diisostearyl malate, isoamyl laurate, *isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate / caprate, coconut alkanes, C9-12 alkane, C13-15 alkane, C13-16 isoalkane, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive -131-WSGR Ref.63230-735.601 oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate / caprate, cetyl stearate, cetearyl stearate, decyl oleate, glyceryl stearate, glyceryl adipate, glyceryl arachidate, glyceryl arachidonate, glyceryl behenate, glyceryl caprate, glyceryl caprylate, glyceryl caprylate / caprate, glyceryl citrate / lactate / linoleate / oleate, glyceryl cocoate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilaurate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl diricinoleate, glyceryl distearate, glyceryl erucate, glycol stearate, isocetyl stearate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearyl stearate, octyl palmitate, octyl stearate, propylene glycol dicaprylate / dicaprate, sorbitan benzoate, sorbitan caprylate, sorbitan isostearate, sorbitan laurate, sorbitan tristearate, stearyl stearate, tocopheryl linoleate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Butyrospermum parkii (shea) butter, Shorea robusta seed butter, murumuru butter, or any combinations thereof.

[0288] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an antioxidant. In some embodiments, the cosmetically or dermatologically acceptable excipient is an antioxidant. Non-limiting example of an antioxidant includes carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropin, Punica granatum bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, or any combinations thereof.

[0289] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a buffer. In some embodiments, the cosmetically or dermatologically acceptable excipient is a buffer. Non-limiting example of a buffer includes ascorbic acid, citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, L-arginine, potassium hydroxide, sodium hydroxide, triethanolamine, sodium bicarbonate, or any combinations thereof.

[0290] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a salt. In some embodiments, the cosmetically or dermatologically acceptable excipient is a salt. Non-limiting example of a salt includes calcium chloride, magnesium -132-WSGR Ref.63230-735.601 chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, or any combinations thereof.

[0291] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an aliphatic alcohol. In some embodiments, the cosmetically or dermatologically acceptable excipient is an aliphatic alcohol. Non-limiting example of an aliphatic alcohol includes aliphatic alcohol selected from: lauric acid, palmitic acid, stearic acid, arachidic alcohol, behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C30-50 alcohols, lanolin alcohol, or any combinations thereof.

[0292] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a perfuming ingredient. In some embodiments, the cosmetically or dermatologically acceptable excipient is a perfuming ingredient. Non-limiting example of a perfuming ingredient include a fragrance such as limonene. In some embodiments, perfuming ingredient comprises a fragrance such as limonene, hydroxycitronellol, benzyl dalicylate, or hexyl cinnamal, or a combination of two or more thereof. Rheology Modifiers

[0293] In some embodiments, the composition described herein further comprises a rheology modifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a rheology modifier. In some embodiments, a conditioner composition comprises a rheology modifier.

[0294] Rheology modifiers generally refer to and include, but are not limited to, substances that are added to alter the viscosity and flow properties of the product. Examples include but are not limited to: thickeners (e.g., xanthan gum, guar gum), gelling agents, emulsion stabilizers, polymeric thickeners (e.g., hydroxyethyl cellulose), clay minerals (e.g., bentonite, hectorite), cellulose derivatives (e.g., carboxymethyl cellulose), silicone polymers, and certain surfactants that can function as rheology modifiers in compositions.

[0295] In some embodiments, the composition comprises a rheology modifier. In some embodiments, the composition comprises one or more rheology modifiers. Compositions

[0296] In some embodiments, the cleanser described herein comprises components of the ingredients of any one of Tables 96-101. In some embodiments, the cleanser described herein is a cleanser of Table 96, Table 97, Table 98, Table 99, Table 100, and Table 101. In some embodiments, the cleanser described herein comprises a formulation described in Table 117 or Table 118. -133-WSGR Ref.63230-735.601 A. Polypeptide and hair conditioner

[0297] In some embodiments, the cleanser described herein comprises a polypeptide (or a peptide) and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, and at least one of: a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Table 102 illustrates non-limiting examples of the cleanser comprising: the polypeptide and the hair conditioner; or the polypeptide and the hair conditioner and at least one additional ingredient. Table 102. Non-limiting examples of a cleanser comprising polypeptide and hair conditioner-134-WSGR Ref.63230-735.601B. Polypeptide and skin conditioner -135-WSGR Ref.63230-735.601

[0298] In some embodiments, the cleanser described herein comprises a polypeptide and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and at least one of: a hair conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, a hair conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Table 103 illustrates non-limiting examples of the cleanser comprising: the polypeptide and the skin conditioner; or the polypeptide and the skin conditioner and at least one additional ingredient. Table 103. Non-limiting examples of cleanser comprising polypeptide and skin conditioner-136-WSGR Ref.63230-735.601C. Polypeptide and cleansing agents -137-WSGR Ref.63230-735.601

[0299] In some embodiments, the cleanser described herein comprises a polypeptide and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, and at least one of: a hair conditioner; a skin conditioner; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, a hair conditioner, a skin conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Table 104 illustrates non-limiting examples of the cleanser comprising: the polypeptide and the cleansing agent (Cleansing Agent); or the polypeptide and the cleansing agent and at least one additional ingredient. Table 104. Non-limiting examples of cleanser comprising polypeptide and cleansing agent-138-WSGR Ref.63230-735.601D. Polypeptide and excipient

[0300] In some embodiments, the cleanser described herein comprises a polypeptide and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser -139-WSGR Ref.63230-735.601 comprises a polypeptide, a cosmetically or dermatologically acceptable excipient, and at least one of: a hair conditioner; a skin conditioner; or a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, a hair conditioner, a skin conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a cosmetically or dermatologically acceptable excipient, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Tables 105-108 illustrate non-limiting examples of the cleanser comprising: the polypeptide and the cosmetically or dermatologically acceptable excipient (e.g., buffering agent as shown in Table 105; chelating agent as shown in Table 106; humectant as shown in Table 107; and preservative as shown in Table 108); or the polypeptide and the cosmetically or dermatologically acceptable excipients and at least one additional ingredient. Table 105. Non-limiting examples of cleanser comprising polypeptide and buffering agent-140-WSGR Ref.63230-735.601Table 106. Non-limiting examples of cleanser comprising polypeptide and chelating agent-141-WSGR Ref.63230-735.601-142-WSGR Ref.63230-735.601Table 107. Non-limiting examples of cleanser comprising polypeptide and humectant-143-WSGR Ref.63230-735.601Table 108. Non-limiting examples of cleanser comprising polypeptide and buffering agent-144-WSGR Ref.63230-735.601

[0301] In some embodiments, the cleanser described herein comprises components of the ingredients or a cleanser formulation of any one of Tables 109-118. In some embodiments, the cleanser described herein is a cleanser formulation of Table 109, Table 110, Table 111, Table 112, Table 113, Table 114, Table 115, Table 116, Table 117, or Table 118. E. Polypeptide and detoxifying agent -145-WSGR Ref.63230-735.601

[0302] In some embodiments, the cleanser described herein comprises a polypeptide and a detoxifying agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, and at least one of: a hair conditioner, a skin conditioner; a cleansing agent; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 109 illustrates non-limiting examples of the cleanser comprising: a polypeptide and a detoxifying agent; or a polypeptide, a detoxifying agent, and at least one additional ingredient. Table 109. Non-limiting examples of cleanser comprising polypeptide and detoxifying agent-146-WSGR Ref.63230-735.601-147-WSGR Ref.63230-735.601F. Polypeptide, detoxifying agent, and hair conditioner

[0303] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and at least one of: a skin conditioner; a cleansing agent; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, a detoxifying agent, a skin conditioner, a cleansing agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair -148-WSGR Ref.63230-735.601 conditioner, and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 110 illustrates non- limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and a hair conditioner; or a polypeptide, a detoxifying agent, a hair conditioner and at least one additional ingredient. Table 110. Non-limiting examples of cleanser comprising polypeptide, detoxifying agent, and hair conditioner-149-WSGR Ref.63230-735.601-150-WSGR Ref.63230-735.601H. Polypeptide, detoxifying agent, and skin conditioner

[0304] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and at least one of: a hair conditioner; a cleansing agent; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, a hair conditioner, a cleansing agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying -151-WSGR Ref.63230-735.601 agent, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 111 illustrates non-limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and a skin conditioner; or a polypeptide, a detoxifying agent, a skin conditioner and at least one additional ingredient. Table 111. Non-limiting examples of cleanser comprising polypeptide, a detoxifying agent. and skin conditioner-152-WSGR Ref.63230-735.601-153-WSGR Ref.63230-735.601I. Polypeptide, detoxifying agent, and cleansing agents

[0305] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, and at least one of: a hair conditioner; a skin conditioner; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, a hair conditioner, a skin conditioner, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 112 illustrates non-limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and a cleansing agent; or a polypeptide, a detoxifying agent, a cleansing agent and at least one additional ingredient. Table 112. Non-limiting examples of cleanser comprising polypeptide, a detoxifying agent, and cleansing agent-154-WSGR Ref.63230-735.601-155-WSGR Ref.63230-735.601-156-WSGR Ref.63230-735.601 Surfactant 0.01-25 4.22 16.3 17.6 7.32 12.3 J. Polypeptide, detoxifying agent, and excipient

[0306] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, an excipient, and at least one of: a hair conditioner; a skin conditioner; or a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, a hair conditioner, a skin conditioner, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, an excipient, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 113 illustrates non-limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and an excipient; or a polypeptide, a detoxifying agent, an excipient, and at least one additional ingredient. Table 113. Non-limiting examples of cleanser comprising polypeptide, detoxifying agent and excipient-157-WSGR Ref.63230-735.601-158-WSGR Ref.63230-735.601K. Polypeptide, detoxifying agent, and fragrance

[0307] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and fragrance. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, and at least one of: a hair conditioner, a skin conditioner; a cleansing agent; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, a hair conditioner, and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, a hair conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, a hair conditioner, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 114 illustrates non-limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and fragrance; or a polypeptide, a detoxifying agent, fragrance, and at least one additional ingredient. Table 114. Non-limiting examples of cleanser comprising polypeptide, detoxifying agent, and Fragrance-159-WSGR Ref.63230-735.601-160-WSGR Ref.63230-735.601Methods

[0308] Provided herein are methods advantageous for protecting hair from ultraviolet damage, mechanical stress damage, and / or environmental damage. In some embodiments, provided are methods of protecting hair of an individual, the method comprising: (a) applying any one of the compositions described herein to the hair of the individual. In some embodiments, the method further comprises: (b) massaging the hair with the composition; and optionally (c) rinsing the hair of the individual.

[0309] In various aspects, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying the composition described herein to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV -161-WSGR Ref.63230-735.601 protection, or a combination of two or more thereof. In various aspects, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying a composition comprising a polypeptide and an emollient to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof. In various aspects, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying a composition comprising a polypeptide and a conditioning agent to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof. In various aspects, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying a composition comprising a polypeptide and a humectant to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof.

[0310] In some aspect, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition described herein to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. In some aspects, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition comprising a polypeptide and an emollient to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. In some aspects, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition comprising a polypeptide and a conditioning agent to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. In some aspects, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the -162-WSGR Ref.63230-735.601 composition comprising a polypeptide and a humectant to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof.

[0311] In some aspects, provided herein is a method for protecting hair of a subject, the method comprising applying the composition described herein to the hair of the subject. In some aspects, provided herein is a method for protecting hair of a subject, the method comprising applying the composition comprising a polypeptide and a lipid nanoparticle to the hair of the subject. In some embodiments, the method further comprises lathering the hair with the composition and rinsing the hair of the subject.

[0312] In some aspects, provided herein is a method for improving the protective properties of a conditioner composition, the method comprising adding an LNP dispersion to the conditioner composition to generate the composition described herein. In some embodiments, the protective property comprises protection against UV damage.

[0313] In some aspects, provided herein is a method for cleansing hair, comprising applying or using a composition comprising a polypeptide and one or more cleansing agents to hair of a subject.

[0314] In some aspects, provided herein is a method for cleansing hair, comprising applying or using a composition comprising a polypeptide and a detoxifying agent to hair of a subject. In some embodiments, provided herein is a is a method for cleansing hair, comprising applying or using a composition comprising a polypeptide, a detoxifying agent, and a hair conditioner, to hair of a subject. Definitions

[0315] Throughout this application, various embodiments may be presented in a range of formats. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the disclosure. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, a description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within that range, for example, 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range. -163-WSGR Ref.63230-735.601

[0316] As used in the specification and claims, the singular forms “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a sample” includes a plurality of samples, including combinations thereof.

[0317] As described herein, the term “percent (%) sequence identity,” and terms related thereto, in the context of amino acid sequences or nucleic acid sequences, is the percentage of amino acid residues or nucleic acid residues in a candidate sequence that are identical with the amino acid residues or nucleic acid residues, respectively, in a selected sequence, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity, and not considering any conservative substitutions as part of the sequence identity. Alignment for purposes of determining percent amino acid sequence identity or percent nucleic acid identity can be achieved in various ways that are within the skill in the art, for instance, using publicly available computer software such as Clustal Omega, BLAST, BLAST-2, ALIGN, ALIGN-2 or Megalign (DNASTAR) software, with BLAST being the alignment algorithm of preference. Those skilled in the art can determine appropriate parameters for measuring alignment, including any algorithms needed to achieve maximal alignment over the full-length of the sequences being compared, although for simplicity it maybe preferred to use default parameters.

[0318] As used herein, the term “individual” is synonymous with patient and / or subject and includes and / or refers to a human and may be a human that has been diagnosed as needing to treat a disease or condition as disclosed herein. However, examples are not limited to humans and include, chimpanzees, marmosets, cows, horses, sheep, goats, pigs, rabbits, dogs, cats, rats, mice, guinea pigs, and the like. The individual is typically a human and may be a human that has been diagnosed as needing to treat a disease or condition as disclosed herein.

[0319] The term “about” or “approximately” as used herein when referring to a measurable value such as an amount or concentration and the like, is meant to encompass variations of 20%, 10%, 5%, 1%, 0.5%, or even 0.1% of the specified amount. For example, “about” can mean plus or minus 10%, per the practice in the art. Alternatively, “about” can mean a range of plus or minus 20%, plus or minus 10%, plus or minus 5%, or plus or minus 1% of a given value. Alternatively, particularly with respect to biological systems or processes, the term can mean within an order of magnitude, up to 5-fold, or up to 2-fold, of a value. Where particular values can be described in the application and claims, unless otherwise stated the term “about” may be assumed to encompass the acceptable error range for the particular value. Also, where ranges, subranges, or both, of values can be provided, the ranges or subranges can include the endpoints of the ranges or subranges. -164-WSGR Ref.63230-735.601

[0320] Where values are described as ranges, it may be understood that such disclosure includes the disclosure of all possible sub-ranges within such ranges, as well as specific numerical values that fall within such ranges irrespective of whether a specific numerical value or specific sub-range is expressly stated.

[0321] The terms “comprise,” “have,” and “include” are open-ended linking verbs. Any forms or tenses of one or more of these verbs, such as “comprises,” “comprising,” “has,” “having,” “includes,” and “including,” are also open-ended. For example, any method that “comprises,” “has,” or “includes” one or more steps is not limited to possessing only those one or more steps and also covers other unlisted steps.

[0322] As used herein, the term “mixture” or “mixtures” is meant to include a simple combination of materials and any compounds that may result from their combination.

[0323] As used herein, the term “cosmeti...

Claims

WSGR Ref.63230-735.601 CLAIMS What is claimed is:

1. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and an emollient comprising polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin / sebacic acid copolymer, C12-15alkyl benzoate, caprylic / capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil / IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate / dicaprate, propylene glycol dicaprylate / dicaprate, triolein (algae oil), propylene glycol dicaprylate / dicaprate, phytosteryl / octyldodecyl lauroyl glutamate, phytosteryl / behenyl / octyldodecyl lauroyl glutamate, phytosteryl / decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, sclerocarya birrea seed oil, tetradecane, isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid / trimethylolpropane copolymer, pentaerythrityl stearate / caprate / caprylate / adipate, neopentyl glycol diethylhexanoate, pentaerythrityl tetraisostearate, bis-behenyl / isostearyl / phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate / caprate, coconut alkanes, C9-12alkane, C13-15alkane, C13-16isoalkane C13-16isoparaffin, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate / caprate, castor isostearate succinate, isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, Sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, isopropyl palmitate, isopropyl palmitate, dicaprylyl ether, -225-WSGR Ref.63230-735.601 didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof, wherein the composition (i) improves cuticle smoothness, shine, or both, (ii) reduces frizz, or (iii) both (i) and (ii).

2. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a conditioning agent comprising a protein comprising hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof, wherein a pH of the composition is about 7 to about 8, and wherein the composition improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof.

3. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a humectant comprising glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof, wherein a pH of the composition is about 5 to about 6, and wherein the composition improves one or more parameters of hair, wherein the parameter comprises moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof.

4. The composition of any one of claims 2-3, further comprising an emollient, wherein the emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof.

5. The composition of claim 4, wherein the polysorbate comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, or a combination of two or more thereof. -226-WSGR Ref.63230-735.601 6. The composition of claim 4 or claim 5, wherein the natural oil comprises coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil, or a combination of two or more thereof.

7. The composition of any one of claims 4-6, wherein the fatty alcohol comprises mystearyl alcohol, palmityl alcohol, stearyl alcohol, cetyl alcohol, cetearyl alcohol, or a combination of two or more thereof.

8. The composition of any one of claims 4-7, wherein the ester comprises cetyl ester, ethylhexyl palmitate, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, methylheptyl isostearate, polyglyceryl-2-diisostearate, di-C12-15 alkyl fumarate, triisostearin, myristyl myristate, palmityl palmitate, myristyl palmitate, tridecyl trimellitate, pentaerythrityl tetraethylhexanoate.

9. The composition of any one of claims 4-8, wherein the ether comprises dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof.

10. The composition of any one of claims 4-9, wherein the emollient comprises cetearyl alcohol, dicaprylyl ether, sunflower oil, polysorbate 20, polysorbate 30, polysorbate 40, fructose, cetyl alcohol, paraffin, sorbitol, glycerin, lanolin, hyaluronic acid, mineral oil, dimethicone, castor isostearate succinate, or a combination of two or more thereof.

11. The composition of any one of claims 1-10, further comprising a conditioning agent.

12. The composition of claim 11, wherein the conditioning agent increases moisture of hair, scalp, or both.

13. The composition of any one of claim 11 or claim 12, wherein the conditioning agent comprises a silicone, a quaternary ammonium compound, a fatty alcohol, a natural oil, a cationic polymer, a ceramide, a polysaccharide, a protein, or a combination of two or more thereof.

14. The composition of any one of claims 11-13, wherein the conditioning agent comprises a natural oil, ester, polysaccharide, protein, or a combination of two or more thereof.

15. The composition of any one of claim 13 or claim 14, wherein the silicone comprises dimethicone, cyclomethicone, cyclopentasiloxane, amodimethicone, PEG-12 dimethicone, dimethiconol, phenyl trimethicone, dimethicone copolyol, stearoxy dimethicone, or behenoxy dimethicone, or a combination of two or more thereof.

16. The composition of any one of claims 13-15, wherein the quaternary ammonium compound comprises cetrimonium chloride, behentrimonium chloride, or both.

17. The composition of any one of claims 1-16, further comprising a preservative, a pH modifier, an antioxidant, a rheology modifier, a film forming agent, or a combination thereof. -227-WSGR Ref.63230-735.601 18. The composition of claim 17, wherein the preservative comprises one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof.

19. The composition of any one of claim 17 or claim 18, wherein the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, or glycolic acid, or a combination thereof.

20. The composition of any one of claims 17-19, wherein the antioxidant comprises a vitamin, a polyphenol, a flavonoid, a carotenoid, a fatty acid, an oil, an enzyme, or a combination thereof.

21. The composition of any one of claims 17-20, wherein film forming agent comprises acrylates / C10-30 alkyl acrylate cross polymer, polyvinylpyrrolidone (PVP) / acrylates cross polymer, PVP / acrylamide cross polymer, polyacrylamidomethylpropane sulfonic acid, octylacrylamide / acrylates / butyl-aminoethyl methacrylate copolymer, vinyl caprolactam / VP / dimethylaminoethyl methacrylate copolymer, and / or polyurethane-48.

22. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a lipid nanoparticle, wherein the lipid nanoparticle comprises: vitamin E or derivative thereof; and a ceramide, wherein the composition minimizes damage to hair and / or scalp from UV rays.

23. The composition of claim 22, further comprising a lipid nanoparticle (LNP) dispersion, wherein the LNP dispersion comprises: a lipid nanoparticle; vitamin E or derivative thereof; and a ceramide.

24. The composition of any one of claim 22 or claim 23, wherein the Vitamin E or derivative thereof is present (% w / w) at 0.1% to 1% by total weight of the LNP dispersion.

25. The composition of any one of claims 22-24, wherein the % by total weight of the LNP dispersion is a measure independent from a % by total weight of the composition.

26. The composition of any one of claims 22-25, wherein the LNP dispersion is present (% w / w) at 0.01% to 5% by total weight of the composition.

27. The composition of any one of claims 22-26, wherein the vitamin E or derivative thereof comprises: tocopheryl acetate, alpha-tocopherol, or a combination thereof. -228-WSGR Ref.63230-735.601 28. The composition of any one of claims 22-27, wherein the vitamin E or derivative thereof is present (% w / w) at 0.0005% to 0.05% by total weight of the composition.

29. The composition of any one of claims 22-28, wherein the ceramide comprises: Ceramide (Cer) 10, Cer 2, Cer 3, Cer 8, Cer 7, Cer 6, Cer 5, Cer 11, EOdS, Cer 1, Cer 9, or Cer 4, or a combination thereof.

30. The composition of any one of claims 22-29, wherein the ceramide is present (%w / w) at 0.0025% to 0.1% by total weight of the composition.

31. The composition of any one of claims 22-30, wherein the lipid nanoparticle is a liposome.

32. The composition of any one of claims 22-31, wherein the composition further comprises a cationic polymer.

33. The composition of claim 32, wherein the cationic polymer is associated with lipids of the lipid nanoparticle.

34. The composition of any one of claim 32 or claim 33, wherein the cationic polymer comprises a polymeric quaternary ammonium compound.

35. The composition of claim 34, wherein the polymeric quaternary ammonium compound comprises polyquaternium-4, polyquaternium-7, polyquaternium-11, polyquaternium-16, polyquaternium-22, or polyquaternium-67.

36. The composition of any one of claims 22-35, further comprising an oil, a preservative, or both the oil and the preservative.

37. The composition of any one of claims 22-36, wherein the polypeptide is present (% w / w) at 0.001% to 1% by total weight of the composition.

38. The composition of any one of claims 22-37, further comprising a second solvent.

39. The composition of claim 38, wherein the second solvent is selected from a group consisting of: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate.

40. The composition of any one of claim 38 or claim 39, wherein the second solvent is present (%w / w) from about 0.1% to about 20% by total weight of the composition.

41. The composition of any one of claims 22-40, further comprising an emulsifier.

42. The composition of claim 41, wherein the emulsifier comprises natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters.

43. The composition of claim 42, wherein the emulsifier comprises lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan -229-WSGR Ref.63230-735.601 olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate / stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla / jojoba / rice bran polyglyceryl- 3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate / stearate, candelilla / jojoba / rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or polyhydroxystearic acid, or a combination thereof.

44. The composition of any one of claim 41-43, wherein the emulsifier is present (w / w%) from about 1% to about 10% by total weight of the composition.

45. The composition of any one of claims 22-44, further comprising a conditioning agent, a humectant, an emollient, a pollution protectant, or a pH modifier.

46. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and one or more cleansing agents comprising an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof, wherein the composition removes dirt from hair, wherein the composition has a pH of about 4 to about 7.

47. The composition of claim 46, wherein the hair conditioner is present in the composition at about 0.01% (%w / w) to about 10% (%w / w).

48. The composition of any one of claim 46 or claim 47, further comprising a skin conditioner.

49. The composition of claim 48, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. -230-WSGR Ref.63230-735.601 50. The composition of any one of claim 48 or claim 49, wherein the skin conditioner is present in the composition at about 0.01% (%w / w) to about 5% (%w / w).

51. The composition of any one of claims 46-50, further comprising a cleansing agent.

52. The composition of claim 51, wherein the total concentration (%w / w) of the cleansing agent is about 5% (%w / w) to about 25% (%w / w).

53. The composition of any one of claim 51 or claim 52, wherein further comprising a hair conditioner.

54. The composition of claim 53, wherein the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof.

55. The composition of any one of claims 46-54, wherein the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof.

56. The composition of any one of claims 46-55, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof.

57. The composition of any one of claims 46-56, further comprising an excipient, wherein the excipient comprises a humectant, a chelating agent, a buffer, a preservative, or a combination thereof.

58. The composition of claim 57, wherein the excipient is present in the composition at about 0.1% (%w / w) to about 30% (%w / w).

59. The composition of any one of claim 57 or claim 58, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof.

60. The composition of any one of claims 57-59, wherein the humectant is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w). -231-WSGR Ref.63230-735.601 61. The composition of any one of claims 57-60, wherein the chelating agent comprises caprylhydroxamic acid, sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or a combination of two or more thereof.

62. The composition of any one of claims 57-61, wherein the chelating agent is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w).

63. The composition of any one of claims 57-62, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof.

64. The composition of any one of claims 57-63, wherein the buffer is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w).

65. The composition of any one of claims 57-64, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof.

66. The composition of any one of claims 57-65, wherein the preservative is present in the composition at about 0.01% (%w / w) to about 0.1% (%w / w).

67. The composition of any one of claims 46-66, further comprising a solvent.

68. The composition of claim 67, wherein the concentration (%w / w) of the solvent is about 50% to about 99%.

69. The composition of any one of claims 46-68, wherein pH of the composition is about 4 to about 6.

70. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a detoxifying agent comprising charcoal, bentonite, hectorite, or a combination thereof, wherein the composition removes sebum and improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof.

71. The composition of claim 70, wherein the detoxifying agent is present in the composition at about 0.01% (w / w) to about 1.0% (w / w).

72. The composition of any one of claim 70 or claim 71, further comprising a hair conditioner.

73. The composition of claim 72, wherein the hair conditioner is present in the composition at about 0.01% (w / w) to about 10% (w / w). -232-WSGR Ref.63230-735.601 74. The composition of any one of claim 72 or claim 73, wherein the hair conditioner comprises panthenol, salicylic acid, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof.

75. The composition of any one of claims 70-74, further comprising a skin conditioner.

76. The composition of claim 75, wherein the skin conditioner is present in the composition at about 0.01% (%w / w) to about 5% (%w / w).

77. The composition of any one of claim 75 or claim 76, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof.

78. The composition of any one of claims 70-77, further comprising a cleansing agent.

79. The composition claim 78, wherein the total concentration (%w / w) of the cleansing agent is about 5% to about 25%.

80. The composition of any one of claim 78 or claim 79, wherein the cleansing agent is a surfactant comprising an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof.

81. The composition of claim 80, wherein the anionic surfactant comprises sodium methyl 2- sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14- 16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof.

82. The composition of claim 81, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof.

83. The composition of any one of claims 70-82, further comprising an excipient comprising a humectant, a chelating agent, a buffer, a preservative, or a combination of two or more thereof.

84. The composition of claim 83, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. -233-WSGR Ref.63230-735.601 85. The composition of any one of claim 83 or claim 84, wherein the humectant is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w).

86. The composition of any one of claims 83-85, wherein the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof.

87. The composition of any one of claims 83-86, wherein the chelating agent is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w).

88. The composition of any one of claims 83-87, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof.

89. The composition of any one of claims 83-88, wherein the buffer is present in the composition at about 0.01% (%w / w) to about 0.5% (%w / w).

90. The composition of any one of claims 83-89, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof.

91. The composition of any one of claims 83-90, wherein the preservative is present in the composition at about 0.01% (%w / w) to about 0.1% (%w / w).

92. The composition of any one of claims 70-91, further comprising a solvent.

93. The composition of claim 92, wherein the concentration (%w / w) of the solvent is about 50% to about 99%.

94. The composition of any one of claims 70-93, wherein pH of the composition is about 2 to about 6.

95. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 8-10, 48, 66-80, and 101-103.

96. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 11-23, 49-55, 82-91, and 104.

97. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 24-32, 56, 92, and 105. -234-WSGR Ref.63230-735.601 98. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 33, 57- 59, 93-95, and 106.

99. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 34, 35, 60, 96, or 107.

100. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 36-42, 61, or 108.

101. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 1-7, 43- 47, and 200-551.

102. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NO: 1 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVGR); SEQ ID NO: 2 (GGVCGPSPPCITTVPGVGVPGVGVPGVGVPGVGVPGVGVPGVG); SEQ ID NO: 3 (GGVCGPSPPCITTGAGAGSGAGAGSGAGAGSGAGAGSGAGAGS); SEQ ID NO: 4 (GGVCGPSPPCITTGGRPSDSYGAPGGGN); SEQ ID NO: 5 (GGVCGPSPPCITTGPTGPTGPAGPRGLQGLQGLQGERGEQGPT); SEQ ID NO: 6 (GGVCGPSPPCITTGGFGGMGGGSGGFGGMGGGSGGFGGMGGGS); SEQ ID NO: 7 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVG); SEQ ID NO: 78 (FCGFPSCSTSC), SEQ ID NO: 79 (CTPPSCCQLHHA).

103. The composition of any one of claims 1-102, wherein the polypeptide is present in the composition at a concentration of about 0.0001% (w / w) to about 20% (w / w).

104. A method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying the composition of any one of claims 1-21 or 95-103 to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, -235-WSGR Ref.63230-735.601 emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof.

105. A method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition of any one of claims 1-21 or 95-103 to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof.

106. A method for protecting hair of a subject, the method comprising applying the composition of any one of claims 22-45 or 95-103 to the hair of the subject.

107. The method of claim 106, further comprising lathering the hair with the composition and rinsing the hair of the subject.

108. A method for improving the protective properties of a conditioner composition, the method comprising adding an LNP dispersion to the conditioner composition to generate the composition of any one of claims 22-45 or 95-103.

109. The method of claim 108, wherein the protective property comprises protection against UV damage.

110. A method for cleansing hair, comprising using the composition of any one of claims 46- 6969 or 95-103.

111. A method for cleansing hair, comprising using the composition of any one of claims 70- 94 or 95-103. -236-

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