Hydrocolloid patch

Abstract

The present invention relates to a hydrocolloid patch for preventing and alleviating acne, comprising: a base layer; and a hydrocolloid layer positioned on the base layer, wherein the hydrocolloid layer comprises a hydrophobic polymer matrix, silicone-based crosspolymer particles dispersed in the hydrophobic polymer matrix, and a moisture absorbent.

Description

hydrocolloid patches

[0001] The present invention relates to a hydrocolloid patch for preventing and improving acne.

[0002] Acne is a common skin disease caused by a combination of factors, including excessive sebum production in pores, abnormal shedding of keratinocytes, and proliferation of acne bacteria. Depending on the symptoms, it is divided into early, middle, and late stages.

[0003] In the early stages, pores become clogged, forming whiteheads and blackheads, and fine red spots appear. In the middle stages, inflammation progresses due to acne bacteria, forming red, painful bumps and pus-filled pustules. In the late stages, large inflammatory nodules and cysts form deep in the skin, causing severe pain and skin damage, and scarring may occur.

[0004] Usually, acne is treated with acne ointment in the early stages, but in the middle or late stages of acne when inflammation has already occurred, hydrocolloid patches are attached to the lesions to treat acne to prevent secondary infection, absorb exudate, create a moist environment, and minimize scar formation.

[0005] However, conventional hydrocolloid patches have low oxygen permeability as they were developed primarily for wound treatment, creating a hypoxic state at the base of the lesion to stimulate neovascularization.

[0006] When hydrocolloid patches with such low oxygen permeability are used for acne, there is a problem in that they may actually promote the growth of the anaerobic bacteria Cutibacterium acnes.

[0007] According to one aspect of the present invention, a hydrocolloid patch with improved oxygen permeability and absorption rate is provided.

[0008] According to one aspect of the present invention, a hydrocolloid patch is provided that can prevent and improve acne and can be used in all stages of acne.

[0009] The objectives of the present invention are not limited to the above-described scope. Those skilled in the art will have no difficulty understanding the additional objectives of the present invention from the overall content of this specification.

[0010] A hydrocolloid patch according to one embodiment of the present invention comprises a base layer; and a hydrocolloid layer positioned on the base layer; wherein the hydrocolloid layer comprises a hydrophobic polymer matrix, silicone-based crosspolymer particles dispersed in the hydrophobic polymer matrix, and a moisture absorbent.

[0011] In a hydrocolloid patch according to one embodiment, the silicone-based crosspolymer may be a siloxane-based crosspolymer.

[0012] In a hydrocolloid patch according to one embodiment, the silicone crosspolymer particles have an average particle diameter (D 50 ) may be 300 ㎛ to 1,200 ㎛.

[0013] In a hydrocolloid patch according to one embodiment, the hydrocolloid layer may include 10 to 100 parts by weight of the silicone-based crosspolymer particles relative to 100 parts by weight of the polymer matrix.

[0014] In a hydrocolloid patch according to one embodiment, the weight ratio of the moisture absorbent to the silicone-based crosspolymer may be 1:0.1 to 1.

[0015] In a hydrocolloid patch according to one embodiment, the moisture absorbent may include a water-swellable polymer.

[0016] In a hydrocolloid patch according to one embodiment, the polymer matrix may include a polyolefin-based polymer and a styrenic block copolymer.

[0017] In one embodiment, the hydrocolloid patch has an oxygen permeability of 200 cm according to ASTM D3985-17 under conditions of a temperature of 23±2°C and a relative humidity of 0%. 3 / m 2 ·It may be more than one day.

[0018] In a hydrocolloid patch according to one embodiment, the absorbency calculated through the following calculation formula 1 may be 5.2% or more.

[0019] [Calculation Formula 1]

[0020] Absorbance = ((W2- W1) / W1) ×100

[0021] In the above calculation formula 1, W1 is the initial weight (g) of the hydrocolloid patch, and W2 is the weight (g) measured after the hydrocolloid patch is immersed in distilled water for 24 hours under conditions of a temperature of 37±1°C and a relative humidity of 20% and then dried for 30 minutes.

[0022] In one embodiment, the hydrocolloid patch may be used for preventing and improving acne.

[0023] A hydrocolloid patch according to one embodiment of the present invention can have excellent oxygen permeability and absorption rate.

[0024] A hydrocolloid patch according to one embodiment of the present invention can prevent and improve acne, and can be used in all stages of acne.

[0025] Figure 1 is a cross-sectional perspective view schematically illustrating a state in which a hydrocolloid patch according to one embodiment of the present invention is attached to the skin;

[0026] Figure 2 is an optical photograph showing an experiment evaluating the ability of a hydrocolloid patch to reduce acne bacteria growth according to one embodiment of the present invention.

[0027] Figure 3 is an optical photograph showing the results of the acne bacteria growth inhibition ability evaluation of Figure 2.

[0028] Figure 4 is a graph showing the results of the acne bacteria growth inhibition ability evaluation of Figure 2.

[0029] Unless otherwise defined, the technical and scientific terms used in this specification have the meaning commonly understood by a person of ordinary skill in the art to which this invention pertains, and descriptions of well-known functions and configurations that may unnecessarily obscure the gist of the present invention in the following description or accompanying drawings are omitted.

[0030] Embodiments of the present invention are provided to more fully explain the present invention to those of ordinary skill in the art. Therefore, the scope of the present invention is not limited to the embodiments described below.

[0031] The terminology used in the description of the present invention is intended solely to describe embodiments of the present invention and is in no way limiting. Unless expressly stated otherwise, singular forms include plural forms.

[0032] The term "includes" in this specification is an open-ended description equivalent to expressions such as "comprises," "contains," "has," or "characterizes," and does not exclude additional elements, materials, or processes not listed.

[0033] Unless otherwise specified, units used herein are based on weight, and as an example, units of % or ratio mean weight% or weight ratio, and weight% means the weight % that any one component of the entire composition occupies in the composition, unless otherwise defined.

[0034] Additionally, the numerical ranges used herein include lower and upper limits and all values ​​within that range, increments logically derived from the shape and width of the defined range, all doubly defined values, and all possible combinations of upper and lower limits of numerical ranges defined in different shapes. Unless otherwise specified herein, values ​​outside the defined numerical range that may arise due to experimental error or rounding of values ​​are also included in the defined numerical range.

[0035] In this specification, terms such as 'top', 'upper part', 'top surface', 'bottom', 'lower part', 'bottom', 'side', etc. are based on the drawings, and in reality, they may vary depending on the direction in which the elements or components are arranged.

[0036] Additionally, throughout the specification, when we say that a part is 'connected' to another part, this includes not only cases where it is 'directly connected', but also cases where it is 'indirectly connected' with other elements in between.

[0037] Although the present invention is described in detail through each embodiment according to the present invention, each embodiment described in the specification should be considered not only to mean a single embodiment but also to mean combinations with other embodiments. Therefore, the citation of a claim in the patent claims is merely an example, and the technical concept of the present invention should not be interpreted solely as a combination with the cited claim, and combinations with various claims also fall within the scope of the technical concept of the present invention.

[0038] In this specification, 'acne' means a common inflammatory lesion that occurs in the hair follicles and sebaceous glands of the skin, and comedones (whiteheads, blackheads), papules (red bumps), and pustules (pus-filled bumps) can all refer to acne.

[0039] In this specification, 'prevention' means suppressing the development of lesions in animals that have not been diagnosed as having such lesions but are predisposed to such lesions.

[0040] In this specification, 'improvement' means any act by which a lesion is alleviated, improved, or beneficially altered.

[0041] Specifically, in the present specification, 'prevention of acne' means preventing acne from progressing to a more serious stage when acne has not yet occurred or is in an early stage, and 'improvement of acne' may mean a method of alleviating an acne condition in the pre-acne stage.

[0042] Conventional hydrocolloid patches have low oxygen permeability as they were developed primarily for wound healing, creating a hypoxic state at the base of the lesion to stimulate neovascularization.

[0043] When hydrocolloid patches with such low oxygen permeability are used for acne, there is a problem in that they may actually promote the growth of anaerobic acne bacteria (Cutibacterium acnes), which may worsen acne.

[0044] According to one embodiment of the present invention, a hydrocolloid patch comprises a base layer; and a hydrocolloid layer positioned on the base layer; wherein the hydrocolloid layer comprises a hydrophobic polymer matrix, silicone-based crosspolymer particles dispersed in the hydrophobic polymer matrix, and a moisture absorbent. Such a hydrocolloid patch has higher oxygen permeability and absorbency than existing hydrocolloid patches. Accordingly, the growth of anaerobic bacteria can be inhibited, while exudates can be easily absorbed.

[0045] A hydrocolloid patch according to one embodiment has high oxygen permeability and absorbency as described above, and can be applied to acne, wounds, abrasions, burns, post-surgical suture sites, bedsores, skin ulcers, blisters, insect bites, bruises, or skin rashes.

[0046] A hydrocolloid patch according to one embodiment can be used for the prevention and improvement of acne. The hydrocolloid patch, with its high oxygen permeability, can supply sufficient oxygen to the lesion while maintaining the moist environment and protective function that hydrocolloids possess, making it highly effective in the prevention and improvement of acne.

[0047] Furthermore, acne is divided into an initial stage in which pores become clogged, forming whiteheads and blackheads and appearing fine red spots; a middle stage in which inflammation progresses due to acne bacteria, forming red, painful papules and pus-filled pustules; and a late stage in which large inflammatory nodules and cysts form deep in the skin, causing severe pain and skin damage and potentially leaving scars. Existing hydrocolloid patches, due to their low oxygen permeability, are only temporarily used to absorb exudates in the middle or late stages when inflammation has already progressed, not in the early stages. However, a hydrocolloid patch according to one embodiment of the present invention can be used throughout the entire acne stage and for a long period of time because it simultaneously has high oxygen permeability and absorbency. Therefore, it is possible to prevent the growth of acne bacteria even in the early stages, thereby preventing the condition from worsening to the middle or late stages in which acne scars may form.

[0048] Specifically, a hydrocolloid patch according to one embodiment has an oxygen permeability of 150 cm according to ASTM D3985-17 under conditions of a temperature of 23±2°C and a relative humidity of 0%. 3 / m 2 ·day or more, 180 cm 3 / m 2·day or more, 200 cm 3 / m 2 ·day or more, 300 cm 3 / m 2 ·day or more, 400 cm 3 / m 2 ·day or more, 500 cm 3 / m 2 ·day or more, 600 cm 3 / m 2 ·day or more or 700 cm 3 / m 2 ·May be more than one day, but not limited to 1500 cm 3 / m 2 ·day or less. Specifically, the oxygen permeability is 150 to 1500 cm 3 / m 2 ·day, 180 to 1200 cm 3 / m 2 ·day, 200 to 1000 cm 3 / m 2 ·day, 300 to 900 cm 3 / m 2 ·day or 400 to 800cm 3 / m 2 ·It could be day.

[0049] Additionally, the hydrocolloid patch according to one embodiment may have an absorbency calculated through the following calculation formula 1 of 5% or more, 5.2% or more, 5.3% or more, or 5.5% or more, and may be, but is not limited to, 10% or less. Specifically, the absorbency may be 5 to 10%, 5.2 to 10%, 5.3 to 9%, 5.5 to 9%, or 6 to 8%.

[0050] [Calculation Formula 1]

[0051] Absorbance = ((W2- W1) / W1) ×100

[0052] In the above calculation formula 1, W1 is the initial weight (g) of the hydrocolloid patch, and W2 is the weight (g) measured after the hydrocolloid patch is immersed in distilled water for 24 hours under conditions of a temperature of 37±1°C and a relative humidity of 20% and then dried for 30 minutes.

[0053] FIG. 1 illustrates a hydrocolloid patch according to one embodiment of the present invention.

[0054] Hereinafter, a hydrocolloid patch according to one embodiment of the present invention will be described in detail with reference to the drawings, but is not limited thereto.

[0055] As described above, a hydrocolloid patch (1) according to one embodiment includes a base layer (10) and a hydrocolloid layer (30).

[0056] When a hydrocolloid patch (1) is attached to the skin, the hydrocolloid layer (30) comes into contact with the skin, and the base layer (10) is exposed to the outside as the outer skin of the patch (1).

[0057] The above base layer (10) serves to protect the skin area (hereinafter, attachment area (A)) to which the hydrocolloid patch (1) is attached from external harmful factors such as water, foreign substances, and bacteria. The base layer (10) is not particularly limited as long as it is a non-toxic material suitable for the skin and has moisture permeability and high flexibility, and is used in a conventional hydrocolloid patch (1). As a specific example, the base layer (10) may include a soft polymer, and is not limited as long as it is a polymer having a glass transition temperature below room temperature. For example, it may be polyurethane, polyethylene, ethylene vinyl acetate resin, or polycaprolactone, but is not limited thereto. In non-limiting embodiments, the base layer (10) may include polyurethane. The base layer (10) has no particular limitation on the thickness, and may be, in non-limiting terms, 10 to 100 ㎛, 20 to 80 ㎛, or 20 to 70 ㎛.

[0058] The above hydrocolloid layer (30) includes a hydrophobic polymer matrix (31), a moisture absorbent (33), and silicone-based cross-polymer particles (35) dispersed in the hydrophobic polymer matrix (31), and is the part that comes into contact with the skin when the hydrocolloid patch (1) is attached to the skin.

[0059] In one embodiment, the hydrocolloid layer (30) may include, but is not limited to, 5 to 100 parts by weight, 10 to 100 parts by weight, 10 to 90 parts by weight, or 30 to 90 parts by weight of the silicone-based crosspolymer particles (35) relative to 100 parts by weight of the polymer matrix (31).

[0060] Additionally, in one embodiment, the hydrocolloid layer (30) may have a weight ratio of the moisture absorbent (33): silicone-based crosspolymer (35) of 1:0.1 to 1, 1:0.2 to 0.9, or 1:0.3 to 0.9.

[0061] The hydrocolloid layer (30) has even better oxygen permeability and absorbency within the above range, and can have adhesive strength that allows adhesion to the skin.

[0062] The hydrophobic polymer matrix (31) may be formed of a single polymer or may include a hydrophobic polymer matrix (31) formed through two or more types of polymers. The polymer forming the hydrophobic polymer matrix (31) is not particularly limited as long as it is a hydrophobic polymer used in a conventional hydrocolloid patch (1). In one embodiment, the hydrophobic polymer matrix (31) may be at least one selected from the group consisting of natural rubber, polyolefin-based polymers, and styrene-based block copolymers.

[0063] In one embodiment, the hydrophobic polymer matrix (31) may include a polyolefin-based polymer and a styrenic block copolymer, and the styrenic block copolymer may include 10 to 50 parts by weight, 15 to 45 parts by weight, or 20 to 40 parts by weight based on 100 parts by weight of the polyolefin-based polymer, but is not limited thereto. The hydrophobic polymer matrix (31) as described above may have excellent flexibility and elasticity that allows for close contact with the skin.

[0064] The polyolefin polymer may be a butylene rubber such as polyisobutylene or a nitrile rubber such as an acrylonitrile-butadiene copolymer. In one embodiment, the polyolefin polymer may be polyisobutylene.

[0065] The above styrenic block copolymer may be at least one selected from a styrene-isoprene-styrene block copolymer (SIS), a styrene-ethylene-butylene-styrene block copolymer (SEBS), and a styrene-ethylene-propylene-styrene copolymer (SEPS). In one embodiment, the styrenic block copolymer may be a styrene-isoprene-styrene block copolymer (SIS).

[0066] The above moisture absorbent (33) has a high moisture content and may be provided in a liquid or particle form. The moisture absorbent (33) is not particularly limited as long as it has the function of absorbing exudates in a mucus state.

[0067] In one embodiment, the moisture absorbent (33) may include a water-swellable polymer. The water-swellable polymer may be pectin, gelatin, or a cellulose derivative. Specifically, the cellulose derivative may be at least one selected from the group consisting of carboxymethylcellulose (CMC), dextran, elastin, chitin, chitosan, and sodium alginate. As a non-limiting example, the moisture absorbent may be carboxymethylcellulose.

[0068] The above silicone cross-polymer particles (35) are provided in the form of particles and are dispersed in the hydrophobic polymer matrix (31), and can play a role in improving oxygen permeability while maintaining mechanical properties such as flexibility and tensile strength of the hydrocolloid layer (30).

[0069] The above silicone-based crosspolymer may be a siloxane-based crosspolymer. The siloxane-based crosspolymer includes dimethylsiloxane as a structural unit, and has the characteristic of being insoluble in a solvent due to the main chains being crosslinked with each other. Specifically, it may be a dimethicone crosspolymer, a dimethicone / vinyldimethicone crosspolymer, a dimethicone / PEG-10 / 15 crosspolymer, a dimethicone / polyglycerin crosspolymer, or a combination thereof.

[0070] Such silicone-based crosspolymers have higher softness, lower specific gravity, superior dispersibility, and superior oxygen permeability than silica, thereby enabling uniform oxygen permeability throughout the entire hydrocolloid layer (30). Specifically, the silicone-based crosspolymer particles (35) can provide a constant supply of oxygen to the acne area (A) through uniform dispersion, thereby further improving acne. In addition, the silicone-based crosspolymer particles (35) can prevent a foreign body sensation upon contact with the skin compared to silica, thereby improving the wearing comfort of the patch (1) and reducing skin irritation.

[0071] The average particle diameter (D) of the above silicone crosspolymer particles (35) 50 ) is not particularly limited, but the average particle diameter (D) of the silicon-based crosspolymer particles (35) 50 ) may be 20 to 1,200 ㎛, 50 to 1,200 ㎛, 100 to 1,200 ㎛ or 300 to 1,200 ㎛. In the above range, the oxygen permeability by the silicone polymer particles can be maximized.

[0072] The average particle size is the volume-based median diameter (D) calculated by laser diffraction. 50 ) can mean volume criterion D 50 It means the particle diameter at the point where the cumulative volume % is 50% in the cumulative distribution curve (cumulative distribution curve) accumulated in order of particle diameter. Experimentally, D 50 The cumulative distribution curve including can be obtained by a conventional particle size analyzer using a laser diffraction method or a dynamic light scattering method.

[0073] In one embodiment, the hydrocolloid layer (30) may further include a tackifier and a plasticizer. The tackifier imparts adhesiveness to the hydrocolloid and may include a phenol-modified terpene; a rosin ester, such as a glycerol ester of rosin and a pentaerythritol ester of rosin; an elastomeric adhesive such as polyisobutylene; a non-elastomeric adhesive including a synthetic polyterpene adhesive; or a combination of two or more thereof.

[0074] The plasticizer may be used to provide wetting action and / or viscosity control. These plasticizers are not particularly limited as long as they are known in the art. Specifically, the plasticizer may include a liquid or soft adhesive, wax, and oil mixture, including hydrocarbon oils, liquid hydrocarbon resins, liquid polyterpenes, liquid poly(isobutylene), for example, GLISSOPAL. As an example, the plasticizer may be paraffin oil.

[0075] In one embodiment, the hydrocolloid patch (1) may further include a release liner film (not shown) positioned on the hydrocolloid layer (30). The hydrocolloid patch (1) further including the release film may have a structure in which the release film-hydrocolloid layer (30)-base layer (10) are laminated in this order. The release film is intended to protect the hydrocolloid layer (30) from external factors before attaching it to the skin and may be removed immediately before attaching the hydrocolloid patch (1) to the skin. The release film is not particularly limited as long as it is used as a release film of a conventional hydrocolloid layer (30). Non-limitingly, the release film may be made of polyethylene terephthalate, polypropylene, or polyethylene, and a release layer such as a silicone thin film may be formed on the film. As a non-limiting example, the release film may be a silicone thin film formed on polyethylene terephthalate.

[0076] Hereinafter, the present invention will be described in detail through examples. However, it should be noted that the examples described below are intended only to illustrate and concretize the present invention and are not intended to limit the scope of the invention. This is because the scope of the invention is determined by the matters set forth in the patent claims and matters reasonably inferred therefrom.

[0077] (Example 1)

[0078] 1) Preparation of hydrocolloid composition

[0079] 150 g of polyisobutylene, 50 g of styrene-isoprene-styrene block copolymer, 100 g of tackifier (Foral™85-E Ester of Hydrogenated Rosin) and 25 g of mineral oil (LP-70) were homogeneously mixed by stirring at 150°C for 40 minutes, then the stirring temperature was reduced to 100°C, and 175 g of carboxymethyl cellulose and 75 g of silicone-based crosspolymer particles (D 50 =28 um, Dimethicone / Vinyldimethicone Crosspolymer) was added and stirred for 30 minutes.

[0080] 2) Manufacturing of hydrocolloid patches

[0081] The hydrocolloid composition manufactured above was coated on a silicone-surface-treated PET film, and then pressed at a temperature of 120°C using a hot press 15 t for 1 minute to manufacture a hydrocolloid layer having a thickness of 0.35 mm. A thermoplastic polyurethane (TPU) substrate having a thickness of 30 μm was laminated on the manufactured hydrocolloid layer to manufacture a hydrocolloid patch.

[0082] (Examples 2 to 5)

[0083] In the above Example 1, a hydrocolloid patch was manufactured in the same manner as in Example 1, except that the hydrocolloid composition was manufactured with the composition described in Table 1 below.

[0084] (Comparative Example 1)

[0085] In the above Example 1, a hydrocolloid patch was manufactured in the same manner as in Example 1, except that silicone-based crosspolymer particles were not added.

[0086] (Comparative Example 2)

[0087] In the above Example 1, a hydrocolloid patch was manufactured in the same manner as in Example 1, except that polysiloxane resin and dimethicone silicone oil were added instead of silicone-based crosspolymer particles.

[0088] ClassificationPIB (g)SIS (g)Tackifier (g)CMC (g)Mineral Oil (g)Si Particles (g)Si D 50 (㎛)Example 115050100175257528Example 2150501001752515028Example 3150501001752515060Example 41505010017525150370Example 515050100175251501110Comparative Example 11505010017525-Comparative Example 21505010017525Silicone resin 75g* PIB: Polyisobutylene* SIS: Styrene-Isoprene-Styrene block copolymer* CMC: Carboxymethylcellulose* Si particles: Dimethicone / Vinyldimethicone Crosspolymer* Silicone Resin: Polysiloxane Resin + Dimethicone Tyl Silicone Oil

[0089] [Measurement of hydrocolloid patch properties]

[0090] 1. Oxygen permeability

[0091] The oxygen permeability of the hydrocolloid patches manufactured in the above examples and comparative examples was measured based on ASTM D 3985-17, and the results are shown in Table 2 below.

[0092] 2. Adhesion

[0093] The hydrocolloid patches manufactured in the above examples and comparative examples were cut to a standard width of 12 mm, and then, after removing the release paper, one end was aligned and attached to a phenol resin test plate having a width of approximately 25 mm, a length of 125 mm, and a thickness of 5 mm. Next, the patches were passed through a rubber roller having a mass of 850 g twice at a speed of 350 mm / min. After 30 minutes, the adhesive strength was measured while peeling at a speed of 300 mm / min at an angle of 180° using a tensile tester, and the results are shown in Table 2 below.

[0094] 3. Absorbency

[0095] The hydrocolloid patches manufactured in the above examples and comparative examples were cut to Φ47 mm, fixed to one flange of a moisture permeable cup, clamped, and measured for weight (W1 (g)). After filling with 20 ml of distilled water, the opposite flange was clamped, and left in an environment of (37 ± 1) ℃ and 20% relative humidity for 24 hours. After that, the opposite flange was opened to drain the distilled water, turned over, and left for 30 minutes, and the weight (W2 (g)) was measured, and the absorbency was measured according to the following calculation formula 1, and the results were recorded in Table 2 below.

[0096] [Calculation Formula 1]

[0097] Absorbance = ((W2- W1) / W1) ×100

[0098] Oxygen permeability [cm 3 / m 2 *24hrs)]Adhesion (gf / 12mm)Absorbency [%]Example 11807836.826Example 24208146.699Example 34807165.609Example 45107355.861Example 57024355.651Comparative Example 11008104.993Comparative Example 21208335.110

[0099] Referring to Table 2 above, it was confirmed that the examples maintained adhesiveness while having superior oxygen permeability compared to the comparative examples. In addition, the hydrocolloid patches according to the examples were expected to have lower absorbency since they contained highly hydrophobic silicone-based crosspolymer particles, but they actually showed higher absorbency than Comparative Example 1. Although it is generally known that absorbency and oxygen permeability are in a trade-off relationship, it is noteworthy that the hydrocolloid patches according to the examples showed a remarkable effect of improving both absorbency and oxygen permeability.

[0100]

[0101] [Evaluation of the acne bacteria growth inhibition ability of hydrocolloid patches]

[0102] In order to evaluate the acne bacteria growth inhibition ability of the hydrocolloid patches manufactured in the above examples and comparative examples, tests were conducted as shown in Fig. 2 and below, and the results were described in Table 3 and Figs. 3 to 4.

[0103] 1) Test strain: Cutibacterium acnes (Accession number: KCTC 3314)

[0104] 2) Test method: The strain was inoculated onto RCM medium and cultured under anaerobic conditions at 37±1°C for 3 days, and then diluted to a concentration of 1.5×10 CFU / mL to prepare a test bacterial solution. The test bacterial solution was injected into each of two test tubes, and as shown in Fig. 2, the inlet of each test tube was sealed with a patch according to Example 1 (Acnes S) and Comparative Example 1 (Acnes H), and cultured at 37±1°C for 2 days. An anaerobic environment was maintained using BD GasPak™ throughout the entire culture process.

[0105] 3) Evaluation method: The cultured bacteria from each test tube were spread on three BHI agar plates, and then cultured at 37±1℃ for 3 days to measure the total number of viable bacteria of acne formed on each plate. Fig. 3 shows an optical image of the plate on which bacteria were cultured after spreading. Specifically, Fig. 3a shows the colony formation result after spreading the culture solution of the test tube sealed with the hydrocolloid patch of Example 1, and Fig. 3b shows the colony formation result after spreading the culture solution of the test tube sealed with the hydrocolloid patch of Comparative Example 1. The total number of viable bacteria formed on each smear and its average and deviation are shown in Table 3 below, and Fig. 4 shows a graph showing the average total number of viable bacteria.

[0106] Total number of viable cells (×10 7 CFU / mL)Mean deviation123Example111101010.30.6Comparative example128222625.33.0

[0107] Referring to Table 3 and FIGS. 3 to 4, it was confirmed that the hydrocolloid patch according to the embodiment inhibited the growth of acne bacteria. Specifically, as shown in FIG. 3, it was confirmed that the number of colonies formed in the hydrocolloid patch according to the embodiment was less than that in the comparative example, to the extent that it was visible to the naked eye. In addition, as shown in Table 3 and FIG. 4, the hydrocolloid patch according to the embodiment reduced acne bacteria by about 31.3% based on the average total number of viable bacteria, but the hydrocolloid patch according to the comparative example increased acne bacteria by about 68.7%. In other words, the embodiment was found to be effective in preventing and improving acne lesions, unlike the comparative example.

Claims

1. Base layer; and A hydrocolloid layer positioned on the base layer; A hydrocolloid patch, wherein the hydrocolloid layer comprises a hydrophobic polymer matrix, silicone-based crosspolymer particles dispersed in the hydrophobic polymer matrix, and a moisture absorbent.

2. In paragraph 1, The above silicone crosspolymer is a hydrocolloid patch that is a siloxane cross-linked polymer.

3. In paragraph 1, The above silicone crosspolymer particles have an average particle diameter (D 50 ) is 300 to 1,200 μm, hydrocolloid patch.

4. In paragraph 1, A hydrocolloid patch, wherein the hydrocolloid layer comprises 10 to 100 parts by weight of the silicone-based crosspolymer particles relative to 100 parts by weight of the polymer matrix.

5. In paragraph 1, A hydrocolloid patch wherein the weight ratio of the above moisture absorbent: the above silicone crosspolymer is 1:0.1 to 1.

6. In paragraph 1, The above moisture absorbent is a hydrocolloid patch comprising a water-swellable polymer.

7. In paragraph 1, A hydrocolloid patch wherein the polymer matrix comprises a polyolefin-based polymer and a styrenic block copolymer.

8. In paragraph 1, The above hydrocolloid patch has an oxygen permeability of 200 cm according to ASTM D3985-17 under conditions of temperature 23±2 ℃ and relative humidity 0%. 3 / m 2 ·Hydrocolloid patch for more than one day.

9. In paragraph 1, A hydrocolloid patch having an absorbency of 5.2% or more as calculated by the following calculation formula 1. [Calculation Formula 1] Absorbance = ((W2- W1) / W1) ×100 (In the above calculation formula 1, W1 is the initial weight (g) of the hydrocolloid patch, and W2 is the weight (g) measured after the hydrocolloid patch is immersed in distilled water for 24 hours under conditions of a temperature of 37±1 ℃ and a relative humidity of 20% and then dried for 30 minutes.) 10. In paragraph 1, The above hydrocolloid patch is a hydrocolloid patch for preventing and improving acne.

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