Support carrier, carrier assembly, and biochemical substance analysis system

Abstract

A support carrier, a carrier assembly, and a biochemical substance analysis system. The support carrier comprises a base, a cover, and an elastic pad. The base is configured to support a slide, and at least one effective area is provided on the slide. The cover is configured to be detachably rotatably connected to the base, so that the cover can be opened and closed relative to the base. The cover is provided with at least one cover opening, and the cover opening is configured to at least partially overlap the effective area in the thickness direction of the support carrier when the cover is closed relative to the base. The elastic pad is provided with at least one cavity opening. The elastic pad is configured to elastically abut between the cover and the slide when the cover is closed relative to the base, so that the cavity opening at least partially overlaps the cover opening in the thickness direction, and one side of the cavity opening is sealed by the slide to form a reaction cavity.

Description

Supporting carrier, carrier assembly and biochemical substance analysis system TECHNICAL FIELD

[0001] The present application relates to the field of carriers, in particular to a supporting carrier, a carrier assembly and a biochemical substance analysis system. BACKGROUND

[0002] In the field of biology, chemistry or medicine, various processing schemes are often used to prepare samples for analysis, which can be performed on a slide. In addition, a carrier can be used to hold a slide containing a sample, and an elastic gasket in the carrier can surround the slide to form a plurality of reaction cavities for users to perform processing such as adding reagents in the reaction cavities.

[0003] However, after the carrier is buckled, the elastic gasket may be damaged due to excessive buckling force, which requires users to replace different carriers, undoubtedly increasing the cost.

[0004] SUMMARY

[0005] Therefore, it is necessary to provide a supporting carrier, a carrier assembly and a biochemical substance analysis system.

[0006] The first aspect of the present application provides a supporting carrier, which comprises a base, a cover and an elastic gasket. The base is configured to support a slide, and the slide is provided with at least one effective area. The cover is configured to be detachably connected to the base in a rotating manner, so that the cover can be opened and closed relative to the base. The cover is provided with at least one cover opening, and the cover opening is configured to at least partially overlap with the effective area in the thickness direction of the supporting carrier when the cover is closed relative to the base. The elastic gasket is provided with at least one cavity opening. The elastic gasket is configured to be elastically supported between the cover and the slide when the cover is closed relative to the base, so that the cavity opening at least partially overlaps with the cover opening in the thickness direction, and one side of the cavity opening is sealed by the slide to form a reaction cavity.

[0007] The second aspect of the present application provides a carrier assembly, which comprises a slide provided with at least one effective area. The carrier assembly further comprises the above-mentioned supporting carrier, and the slide is arranged on the base of the supporting carrier, and the elastic gasket is elastically supported between the cover and the slide.

[0008] The third aspect of the present application provides a biochemical substance analysis system, which comprises the above-mentioned carrier assembly.

[0009] In the present application, the cover is rotatably connected to the base, and during the process of gradually closing the cover relative to the base, the slide can contact different areas of the elastic gasket in sequence, that is, the cover and the slide can cooperate with each other to make the elastic gasket slowly deform elastically. Compared with the scheme of buckling the cover in the vertical direction relative to the base, the present application can reduce the risk of damaging the elastic gasket due to excessive buckling force, and avoid the increase in cost caused by replacing the supporting carrier.BRIEF DESCRIPTION OF DRAWINGS BRIEF DESCRIPTION OF DRAWINGS

[0010] Fig. 1 is a block diagram of a biochemical substance analysis system according to an embodiment of the present application.

[0011] Fig. 2 is a schematic diagram of a structure of a slide of a carrier assembly of the biochemical substance analysis system shown in Fig. 1 in some embodiments.

[0012] Fig. 3 is a schematic diagram of a structure of the slide shown in Fig. 2 in other embodiments.

[0013] Fig. 4 is a schematic diagram of a structure of the carrier assembly of the biochemical substance analysis system shown in Fig. 1.

[0014] Fig. 5 is a schematic diagram of a structure of the carrier assembly shown in Fig. 4 from another angle.

[0015] Fig. 6 is a side view of the carrier assembly shown in Fig. 4.

[0016] Fig. 7 is a top view of the carrier assembly shown in Fig. 4.

[0017] Fig. 8 is an exploded view of the carrier assembly shown in Fig. 4.

[0018] Fig. 9 is an exploded view of the carrier assembly shown in Fig. 4 from another angle.

[0019] Fig. 10 is a sectional view of the carrier assembly shown in Fig. 4 along line II-II.

[0020] Fig. 11 is a sectional view of the carrier assembly shown in Fig. 10 in another state.

[0021] Fig. 12 is a schematic diagram of a structure of a carrier assembly according to another embodiment of the present application.

[0022] Fig. 13 is a schematic diagram of a structure of a carrier assembly according to still another embodiment of the present application.

[0023] Explanation of main component symbols

[0024] Biochemical substance analysis system 1

[0025] Carrier assembly 2, 2a, 2b

[0026] Pipetting device 3

[0027] Temperature control device 4

[0028] Substrate 10

[0029] First side wall 11

[0030] Second side wall 12

[0031] Third side wall 13

[0032] Fourth side wall 14

[0033] Base portion 15

[0034] First accommodating groove 16

[0035] Notch 17

[0036] Connecting platform 18

[0037] Cover body 20

[0038] Fifth side wall 21

[0039] Sixth side wall 22

[0040] Cover portion 23

[0041] First abutting member 24

[0042] Second abutting member 25

[0043] Boss 26

[0044] Positioning column 27

[0045] Elastic pad 30

[0046] Support carrier 100

[0047] First clasp 111

[0048] Second inclined surface 120

[0049] Second clasp 121

[0050] Side protruding portion 140

[0051] Base opening 150

[0052] Slide 200

[0053] Effective area 201

[0054] Slide body 202

[0055] Chip 203

[0056] Shaft portion 210

[0057] First clamping groove 211

[0058] Chamfer 212

[0059] First inclined surface 220

[0060] Second clamping groove 221

[0061] First surface 231

[0062] Second surface 232

[0063] Second accommodating groove 233

[0064] First arc convex surface 241

[0065] Connecting end 251

[0066] Free end 252

[0067] Second arc convex surface 253

[0068] Slot 1110

[0069] First clamping surface 1111

[0070] Second clamping surface 1112

[0071] Third clamping surface 1211

[0072] Fourth clamping surface 1212

[0073] Cover opening 2001

[0074] first opening edge 2001a

[0075] second opening edge 2001b

[0076] first opening portion 2001c

[0077] second opening portion 2001d

[0078] bottom surface 2330

[0079] cavity opening 3001

[0080] positioning groove 3002

[0081] support surface P1

[0082] reaction cavity C

[0083] first direction X

[0084] second direction Y

[0085] third direction Z

[0086] The following detailed description will further describe the present application with reference to the above drawings. DETAILED DESCRIPTION

[0087] The technical solutions in the embodiments of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments of the present application.

[0088] It should be noted that when a component is referred to as being "fixed" or "mounted" to another component, it can be directly on the other component or there can be a middle component. When a component is referred to as being "disposed" on another component, it can be directly disposed on the other component or there can be a middle component. The term "and / or" as used herein includes all possible combinations of one or more relevant listed items.

[0089] Referring to FIG. 1, an embodiment of the present application provides a biochemical substance analysis system 1 comprising a carrier assembly 2. Referring to FIGS. 2-4, the carrier assembly 2 comprises a support carrier 100 and a slide 200 detachably mounted in the support carrier 100. The slide 200 is provided with at least one effective area 201, and the effective area 201 can be pre-provided with a biological sample. However, it is understood that the biological sample can also be added to the effective area 201 when a biochemical reaction is needed. The support carrier 100 is used to define a reaction cavity C corresponding to the effective area 201 on the slide 200. For example, the reaction cavity C can correspond to the effective area 201 one by one. As shown in FIG. 1, the biochemical substance analysis system 1 can further comprise a pipetting device 3 and one or more assay reagents, and the pipetting device 3 is used to add the assay reagents into the reaction cavity C so that the biological sample and the assay reagents have a biochemical reaction in the reaction cavity C. The biochemical substance analysis system 1 can further comprise a temperature control device 4. The temperature control device 4 is used to heat or cool the liquid in the reaction cavity C, thereby providing a suitable temperature for the biochemical reaction. The biochemical substance analysis system 1 can be a spatial analysis instrument. In other embodiments, the specific type of the biochemical substance analysis device can also be changed according to its actual function.

[0090] As shown in FIG. 2, in some embodiments, the slide 200 comprises a slide body 202 and at least one chip 203 provided on the slide body 202. The chip 203 is provided with the effective area 201. The chip 203 can be directly arranged on the surface of the slide body 202 by pasting or other means, and the chip 203 can also be at least partially arranged in a groove provided on the surface of the slide body 202. The slide body 202 can be a glass slide. As shown in FIG. 3, in other embodiments, the effective area 201 can also be directly formed on the surface of the slide body 202. In some specific embodiments, the length of the slide 200 is 75-75.5 mm, the width is 25-25.5 mm, the thickness is 1-1.1 mm, and the area of each effective area 201 can be approximately 10 mm x 10 mm or 5 mm x 5 mm.

[0091] Referring to FIGS. 4-10, the support carrier 100 includes a base 10, a cover 20, and a resilient pad 30. The base 10 is configured to support the support sheet 200. For example, the base 10 includes a support surface P1 (shown in FIGS. 8 and 10) configured to support the support sheet 200, and a bottom surface of the support sheet 200 can be in contact with the support surface P1 of the base 10. The cover 20 is configured to be detachably rotatably connected to the base 10, such that the cover 20 is configured to be openable and closable relative to the base 10. The cover 20 is provided with at least one cover opening 2001 corresponding to the effective area 201. For example, the cover opening 2001 can correspond to the effective area 201 one-to-one. Here, "corresponding" means that when the cover 20 is closed relative to the base 10, each cover opening 2001 at least partially overlaps with one of the effective areas 201 as viewed from the stacking direction of the cover 20 and the base 10 (i.e., the thickness direction of the support carrier 100, hereinafter referred to as the third direction Z). The cover opening 2001 can be provided as a convex polygon such as a hexagon, a square, or a triangle as viewed from the third direction Z. FIGS. 4-10 show the cover opening 2001 as a hexagon.

[0092] The elastic pad 30 can be arranged on the surface of the cover 20 facing the base 10, or on the surface of the base 10 facing the cover 20. The elastic pad 30 can also be arranged independently and then arranged on the surface of the cover 20 facing the base 10 or on the surface of the base 10 facing the cover 20 when needed. The elastic pad 30 is provided with at least one cavity opening 3001, which can penetrate the elastic pad 30 along the third direction Z. The cavity opening 3001 corresponds to the cover opening 2001. For example, the cavity opening 3001 can correspond to the cover opening 2001 one by one. Here, "corresponding" means that when the cover 20 is closed relative to the base 10, each cover opening 2001 and one cavity opening 3001 at least partially overlap when viewed from the third direction Z. Among them, the cavity opening 3001 can be arranged as a convex polygon such as a hexagon, a square or a triangle when viewed from the third direction Z. Figures 4 to 10 show that the cavity opening 3001 is a hexagon. The elastic pad 30 is made of an elastic material, which can elastically deform and elastically abut between the cover 20 and the carrier 200 when the cover 20 is closed relative to the base 10, so that one side of the cavity opening 3001 is sealed by the carrier 200 to form a reaction cavity C. It can be understood that when the number of effective areas 201 on the carrier 200 is multiple, the number of reaction cavities C is also multiple and independent of each other. Among them, the two sides of the reaction cavity C correspond to the effective area 201 and the cover opening 2001, respectively. The assay reagent can be added into the reaction cavity C through the cover opening 2001, so as to react or interact with the biological sample on the effective area 201. In some embodiments, the material of the elastic pad 30 is selected from at least one elastic material among silica gel, rubber and ethylene-propylene rubber (such as ternary ethylene-propylene rubber). Further, the elastic pad 30 will be in direct contact with the assay reagent during the biochemical reaction, so the elastic pad 30 can be made of a material compatible with the assay reagent. It can be understood that generally the liquid level in the reaction cavity C does not exceed the thickness of the elastic pad 30, however, in order to avoid liquid dripping on the cover 20 or part of the assay reagent vaporizing and contacting the cover 20 during the liquid adding process, the cover 20 can also be made of a material compatible with the assay reagent.

[0093] In this application, the base 10 provides a larger area support for the carrier 200, and since the cover 20 is rotatably connected to the base 10, the carrier 200 can contact different areas of the elastic pad 30 in sequence during the process of gradually closing the cover 20 relative to the base 10, that is, the cover 20 and the carrier 200 can cooperate with each other to make the elastic pad 30 slowly deform. Compared with the scheme of clamping the cover 20 on the base 10 along the third direction Z, the application can reduce the risk of damaging the elastic pad 30 due to excessive clamping force. After the elastic pad 30 is elastically deformed, the elastic force of the elastic pad 30 can be uniformly distributed to the carrier 200, and the support device 100 can bind the carrier 200 inside to reduce the shear stress and torsional stress of the elastic pad 30 on the carrier 200.

[0094] In some embodiments, the elastic pad 30 is detachably arranged on the surface of the cover 20 facing the base 10. The assay reagent in the biochemical reaction process generally only contacts the elastic pad 30 of the support carrier 100, and the elastic pad 30 is detachably arranged on the cover 20, so that the elastic pad 30 can be replaced individually for different biochemical reactions, thereby avoiding the increase in cost after the whole support carrier 100 is replaced.

[0095] In some embodiments, the base 10 includes a base portion 15, a first side wall 11, a second side wall 12, a third side wall 13, and a fourth side wall 14, which can be integrally formed. The first side wall 11 and the second side wall 12 are oppositely arranged in a first direction X, and the third side wall 13 and the fourth side wall 14 are oppositely arranged in a second direction Y. The first direction X and the second direction Y can be the width direction and the length direction of the base 10, respectively. The first side wall 11, the second side wall 12, the third side wall 13, and the fourth side wall 14 are arranged around the edge of the base portion 15, and the first side wall 11, the third side wall 13, the second side wall 12, and the fourth side wall 14 are sequentially connected. The base portion 15, the first side wall 11, the second side wall 12, the third side wall 13, and the fourth side wall 14 jointly define a first accommodating groove 16 (shown in FIG. 8) for accommodating the slide 200. When the slide 200 is placed in the first accommodating groove 16, the first side wall 11 and the second side wall 12 can limit the slide 200 in the first direction X, and the third side wall 13 and the fourth side wall 14 can limit the slide 200 in the second direction Y, so that the slide 200 can be positioned on the base 10. In other embodiments, the fourth side wall 14 can also be omitted. In this case, the first side wall 11 and the second side wall 12 are oppositely arranged in the first direction X, and the third side wall 13 is connected to the first side wall 11 and the second side wall 12. At this time, the first side wall 11 and the second side wall 12 limit the slide 200 in the first direction X, and the third side wall 13 limits the slide 200 in the second direction Y. When the fourth side wall 14 is omitted, the second side wall 12 and the third side wall 13 can also be oppositely arranged in the second direction Y, and the first side wall 11 is connected to the second side wall 12 and the third side wall 13. At this time, the first side wall 11 limits the slide 200 in the first direction X, and the second side wall 12 and the third side wall 13 limit the slide 200 in the second direction Y.

[0096] As shown in FIGS. 8 and 9, further, the connecting portion of the base portion 15 and the third side wall 13 is provided with a notch 17, which is in communication with the first accommodating groove 16. The notch 17 facilitates the user to take and place the slide 200. In some embodiments, the material of the base 10 can be at least one of polyether ether ketone (PEEK) and polyetherimide (PEI) having high mechanical strength and heat resistance. In this way, the base 10 can protect the slide 200, and reduce the risk of the slide 200 being damaged due to the brittle texture of the slide 200 after the base 10 is distorted by external force. Moreover, when the liquid in the reaction cavity C is heated, the base 10 has high mechanical strength and heat resistance, so that the risk of the base 10 being deformed at high temperature is reduced, thereby reducing the risk of the base 10 being deformed to cause the elastic pad 30 to be compressed and fail, and thus the reaction cavity C cannot be sealed. In addition, the slide 200 can be grabbed and transferred by an automated gripper (not shown) before and after the biochemical reaction. Since the base 10 has high mechanical strength, the risk of the base 10 being bent by force when grabbed by the gripper is reduced.

[0097] The cover 20 includes a cover portion 23 and a fifth side wall 21. In some embodiments, the cover 20 can further include a sixth side wall 22. The cover portion 23, the fifth side wall 21, and the sixth side wall 22 can be integrally formed. The cover portion 23 includes a first surface 231 facing the base portion 15 and a second surface 232 away from the first surface 231, and the fifth side wall 21 and the sixth side wall 22 are protruded from the first surface 231. A cover opening 2001 is provided on the cover portion 23 and penetrates the cover portion 23 along the third direction Z. The fifth side wall 21 and the sixth side wall 22 are connected to the cover portion 23 and oppositely arranged in the first direction X. The fifth side wall 21 is used to detachably rotate and connect the first side wall 11, so that the cover 20 and the base 10 are rotatably connected.

[0098] As shown in FIG. 8, in some embodiments, the first side wall 11 and the second side wall 12 are respectively provided with a first abutting member 24 and a second abutting member 25. The first abutting member 24 and the second abutting member 25 are both protrudingly arranged towards the first accommodating groove 16 along the first direction X, and the first abutting member 24 can be integrally formed with the first side wall 11, and the second abutting member 25 can be integrally formed with the second side wall 12. The first abutting member 24 is used for rigidly abutting to one side surface of the slide 200, and the second abutting member 25 is used for elastically abutting to the other side surface of the slide 200, so that the slide 200 can be further limited in the first direction X, thereby reducing the risk of movement of the slide 200 in the support carrier 100. When the slide 200 is installed, the slide 200 can be placed on the base portion 15 and pushed to the side of the first abutting member 24, and then the second abutting member 25 elastically acts on the slide 200, thereby improving the positioning accuracy of the slide 200. Moreover, the first abutting member 24 and the second abutting member 25 jointly clamp the slide 200, thereby improving the stability of the slide 200 in the support carrier 100, and even if the support carrier 100 is turned over, the risk of the slide 200 being separated can be reduced. The number of the first abutting member 24 can be multiple, and the number of the second abutting member 25 can also be multiple, thereby further improving the positioning accuracy. In other embodiments, the first abutting member 24 or the second abutting member 25 can be provided alone, and the slide 200 is limited by the first abutting member 24 or the second abutting member 25.

[0099] The first abutting member 24 can be a protrudingly arranged positioning block, and the second abutting member 25 can be an elastic arm integrally connected to the second side wall 12. The elastic arm has a connecting end 251 connected to the second side wall 12 and a free end 252 separated from the second side wall 12. When the elastic arm is subjected to an external force (such as being pressed by the slide 200), the free end 252 can move close to the second side wall 12. At the same time, the elastic arm has a restoring potential, so that the free end 252 elastically abuts to the slide 200 under the action of the restoring potential. It can be understood that the free end 252 has a limit position when moving close to the second side wall 12, and the distance between the limit position and the first abutting member 24 in the first direction X is the maximum width of the slide 200 adapted; in the case where the slide 200 is not put in, the distance between the free end 252 and the first abutting member 24 in the first direction X is the minimum width of the slide 200 adapted, and the slide 200 smaller than the minimum width cannot be elastically abutted by the second abutting member 25. In some specific embodiments, the width of the slide 200 is 25mm to 25.5mm, the above-mentioned maximum width is 26mm, and the minimum width is 24.5mm.

[0100] In addition, as shown in FIG. 8, the first abutting member 24 can further include a first arc-shaped convex surface 241, and the free end 252 of the second abutting member 25 can include a second arc-shaped convex surface 253. The first arc-shaped convex surface 241 and the second arc-shaped convex surface 253 are used to abut against different sides of the slide 200. In this way, the contact area between the first abutting member 24 and the side of the slide 200 is a circular arc, and the contact area between the second abutting member 25 and the side of the slide 200 is also a circular arc. In this way, when the slide 200 is installed, the risk that the first abutting member 24 and the second abutting member 25 collide with the side of the slide 200 and cause the slide 200 to break can be reduced.

[0101] As shown in FIGS. 4, 7, 8, and 10, in some embodiments, the first side wall 11 includes a first clamping portion 111 that is arranged to protrude away from the first accommodating groove 16 in the first direction X, and the first clamping portion 111 can be integrally formed on the first side wall 11. As shown in FIG. 10, the first clamping portion 111 includes a first clamping surface 1111 and a second clamping surface 1112 that are arranged opposite to each other in the third direction Z, and the first clamping surface 1111 is farther away from the cover 23 than the second clamping surface 1112. The first clamping surface 1111 is provided with a slot 1110, and the slot 1110 can have a semicircular cross section. The fifth side wall 21 includes a shaft portion 210 that can be integrally formed on the fifth side wall 21. The shaft portion 210 is arranged to be detachably rotatable in the slot 1110, so that the fifth side wall 21 and the first side wall 11 are rotatably connected. The fifth side wall 21 is further provided with a first clamping groove 211, and the first clamping portion 111 is arranged to extend into the first clamping groove 211 when the cover 20 is gradually closed relative to the base 10. FIG. 10 shows a structure schematic view of the cover 20 after being closed relative to the base 10, and FIG. 11 shows a structure schematic view of the cover 20 after being opened relative to the base 10. The cover 20 is rotatable relative to the base 10, so that the carrier assembly 2 can be switched from the structure shown in FIG. 11 to the structure shown in FIG. 10. As shown in FIGS. 10 and 11, during the rotation of the cover 20 relative to the base 10, the relative positions of the fifth side wall 21 and the first side wall 11 in the second direction Y are limited because the first clamping portion 111 extends into the first clamping groove 211. In some embodiments, the number of the first clamping portions 111 is plural, so as to further improve the positioning effect of the fifth side wall 21 and the first side wall 11 in the second direction Y. Further, the plural first clamping portions 111 are distributed to the end of the first side wall 11 in the second direction Y, so as to increase the supporting and fixing effect of the base 10 on the cover 23 and reduce the risk of thermal deformation of the carrier assembly 2.

[0102] Further, as shown in FIG. 5, FIG. 7 and FIG. 10, the second side wall 12 comprises a second buckle 121 protruding away from the first accommodating groove 16 along the first direction X, and the second side wall 12 and the second buckle 121 can be integrally formed. The second buckle 121 comprises a third buckle surface 1211 and a fourth buckle surface 1212 (shown in FIG. 10) oppositely arranged along the third direction Z, and the third buckle surface 1211 is farther away from the cover 23 than the fourth buckle surface 1212. The sixth side wall 22 is provided with a second buckle groove 221. As shown in FIG. 10 and FIG. 11, the second buckle 121 is used to extend into the second buckle groove 221 when the cover 20 is rotated and gradually closed relative to the base 10, so that the third buckle surface 1211 abuts against the second buckle groove 221. Therefore, since the second buckle 121 extends into the second buckle groove 221, the relative position of the sixth side wall 22 and the second side wall 12 along the second direction Y is limited, and in combination with the arrangement of the first buckle 111 and the first buckle groove 211, the alignment tolerance of the cavity opening 3001 on the elastic pad 30 and the effective area 201 along the first direction X after the cover 20 is closed relative to the base 10 can be controlled. Moreover, since the third buckle surface 1211 abuts against the second buckle groove 221, the cover 20 can be stably buckled to the base 10, reducing the risk of reopening of the cover 20 relative to the base 10, and also reducing the risk of separation of the shaft portion 210 from the groove 1110. Furthermore, the cover 20 is stably connected to the base 10 through the cooperation of the buckle and the buckle groove, and due to the fixing effect of the base 10, the risk of deformation of the cover 20 under high temperature can be reduced. In addition, through the cooperation of the buckle and the buckle groove on the side wall, the overall thickness of the support carrier 100 can be reduced, thereby widening the application field of the support carrier 100, so that it can be used in more types of biochemical substance analysis systems 1. Among them, the third buckle surface 1211 can be a plane, so that the third buckle surface 1211 can more stably abut against the second buckle groove 221. In some specific embodiments, the length of the support carrier 100 is 81 mm, the width is 40 mm, and the thickness is 12 mm.

[0103] In some embodiments, the fourth buckle surface 1212 is an arc-shaped convex surface. As shown in FIG. 6 and FIG. 10, the surface of the sixth side wall 22 towards the fifth side wall 21 is provided with a first inclined surface 220, which is arranged obliquely relative to the plane defined by the first direction X and the third direction Z. When the cover 20 is rotated and gradually closed relative to the base 10, the first inclined surface 220 is used to abut against the fourth buckle surface 1212 until the third buckle surface 1211 of the second buckle 121 abuts against the groove wall of the second buckle groove 221. Therefore, the fourth buckle surface 1212 and the first inclined surface 220 play a guiding role in the rotation process of the cover 20, facilitating the connection of the second buckle 121 and the second buckle groove 221.

[0104] In the process from the abutting of the first inclined surface 220 to the fourth clamping surface 1212 to the insertion of the second clamping 121 into the second card slot 221, the sixth side wall 22 needs to open a certain angle compared to the cover portion 23, so as to facilitate the insertion of the second clamping 121 into the second card slot 221; after the second clamping 121 is inserted into the second card slot 221, the sixth side wall 22 needs to return to the original state compared to the cover portion 23. That is, the sixth side wall 22 can open and close a predetermined angle compared to the cover portion 23, and the predetermined angle can be set according to the size of the second clamping 121, which is not limited in the present application. In order to facilitate the opening and closing of the sixth side wall 22 compared to the cover portion 23, the cover body 20 can be made of a material with high toughness, for example, the material of the cover body 20 can be polypropylene, so that the risk of breaking of the cover body 20 when the sixth side wall 22 is opened compared to the cover portion 23 can be reduced, and the sixth side wall 22 can quickly return to the original state. In order to facilitate the opening and closing of the sixth side wall 22 compared to the cover portion 23, the sixth side wall 22 can also have a smaller thickness. Therefore, as shown in FIGS. 6 and 10, in some embodiments, the thickness of the fifth side wall 21 is greater than the thickness of the sixth side wall 22, and the thickness of the cover portion 23 is greater than the thickness of the sixth side wall 22. At the same time, since the thicknesses of the fifth side wall 21 and the cover portion 23 are relatively large, the overall strength of the cover body 20 can be maximized while facilitating the opening of the sixth side wall 22, and the thermal deformation of the cover body 20 at high temperatures can be reduced.

[0105] As shown in FIGS. 6 and 10, the surface of the second side wall 12 away from the first side wall 11 can also be provided with a second inclined surface 120, which is inclined compared to the plane defined by the first direction X and the third direction Z. The first inclined surface 220 and the second inclined surface 120 are respectively inclined away from each other and jointly define an operation space. In this way, the user can insert the operating member (such as a finger or another tool) into the operation space and pry the sixth side wall 22 to make the second clamping 121 disengage from the second card slot 221, so as to open the cover body 20 compared to the base 10, facilitating the removal or replacement of the slide 200.

[0106] As shown in FIG. 4 and FIG. 8, in some embodiments, the fourth side wall 14 extends beyond the base portion 15 to form a side protrusion 140 along the first direction X. The base 10 further comprises a connecting platform 18 disposed between the side protrusion 140 and the base portion 15. The connecting platform 18 can be a triangular pyramid, and correspondingly, the connecting platform 18 can be substantially triangular when viewed from the third direction Z. The fifth side wall 21 is provided with a chamfer 212 at a corner thereof, which is configured to avoid the connecting platform 18 when the first clasp 111 is inserted into the first clasp slot 211. When the cover 20 is opened relative to the base 10, the chamfer surface formed by the chamfer 212 can abut or be parallel to the side surface of the triangular pyramid, and when the cover 20 is rotated relative to the base 10 and gradually closed, the chamfer surface formed by the chamfer 212 can gradually move away from the side surface of the triangular pyramid. Since the sixth side wall 22 is not provided with a chamfer at a corner thereof for avoiding the connecting platform 18, the first clasp 111 cannot be inserted into the second clasp slot 221, thereby avoiding the user from mistakenly taking one side of the sixth side wall 22 as the rotation axis of the cover 20, and achieving a foolproof effect. In some embodiments, the number of the connecting platforms 18 can be two, which are respectively located on both sides of the shaft portion 210 along the second direction Y.

[0107] As shown in FIG. 4 to FIG. 8 and FIG. 10, in some embodiments, the cover 20 further comprises a boss 26 protrudingly disposed on the second surface 232 of the cover portion 23. The cover opening 2001 further penetrates the boss 26. The boss 26 can be provided with a sealing member (not shown), such as a sealing film. The sealing film can cover the cover opening 2001, thereby avoiding external impurities from entering the cover opening 2001 and the cavity opening 3001 and affecting subsequent biochemical reactions. Moreover, the area of the surface of the boss 26 is smaller than the area of the surface of the cover portion 23, and thus the flatness of the surface of the boss 26 is easier to control, so that the boss 26 can be tightly attached to the sealing member, thereby achieving a better sealing effect.

[0108] As shown in FIG. 4, FIG. 5 and FIG. 7, the cover opening 2001 disposed on the boss 26 comprises a first opening edge 2001a and a second opening edge 2001b when viewed from the third direction Z, and the first opening edge 2001a is farther away from the cover portion 23 than the second opening edge 2001b. The first opening edge 2001a is disposed around the second opening edge 2001b when viewed from the third direction Z. That is, the inner wall of the cover opening 2001 disposed on the boss 26 is also an inclined surface. Therefore, on the one hand, the observation field of view of the user can be expanded, thereby facilitating the user to observe the biochemical reaction in the reaction cavity C, and on the other hand, the movable space of the pipetting device 3 in the reaction cavity C can be increased, and especially for the inverted conical pipette tip, the inclined surface can also provide a guiding effect for the pipette tip to enter the reaction cavity C.

[0109] As shown in FIG. 7, in some embodiments, each cover opening 2001 can cover the corresponding entire effective area 201, i.e. the effective area 201 is located within the cover opening 2001, as viewed from the third direction Z. The cover opening 2001 comprises a first opening part 2001c overlapping the effective area 201 and a second opening part 2001d located outside the effective area 201, and the first opening part 2001c and the second opening part 2001d are connected to form the cover opening 2001. Therefore, the pipette device 3 can extend into the reaction cavity C through the second opening part 2001d and approach the effective area 201 in the third direction Z, so as to perform the pipetting operation. Since the pipette device 3 extends through the second opening part 2001d, the effective area 201 can be avoided to prevent the pipette device 3 from colliding with or even damaging the effective area 201 during pipetting. Moreover, it is also beneficial to reduce the residual liquid amount.

[0110] In some embodiments, as viewed from the third direction Z, the cover opening 2001 and the cavity opening 3001 can be hexagons, and the effective area 201 and the first opening part 2001c can be squares, and the number of the second opening part 2001d is two and each is a triangle. The two second opening parts 2001d can be oppositely arranged in the first direction X or in the second direction Y. At this time, the pipette device 3 can extend into the reaction cavity C through the second opening part 2001d in the form of a triangle to perform the pipetting operation. Specifically, the triangular corner of the second opening part 2001d can be provided with a rounded corner to facilitate the liquid to gather in the triangular area and improve the efficiency of the pipetting operation.

[0111] As shown in FIG. 9 and FIG. 10, in some embodiments, the first surface 231 of the cover portion 23 is provided with a second accommodating groove 233 for accommodating a part of the elastic pad 30, and another part of the elastic pad 30 protrudes from the second accommodating groove 233. The cover opening 2001 penetrates the bottom surface 2330 of the second accommodating groove 233 and the second surface 232, and the cover opening 2001 communicates with the second accommodating groove 233. In some embodiments, the cover 20 further comprises a positioning column 27 protruding from the bottom surface 2330 of the second accommodating groove 233. The elastic pad 30 is provided with a positioning groove 3002, and the positioning column 27 is used to extend into the positioning groove 3002. Therefore, the elastic pad 30 can be positioned on the cover 20, reducing the dislocation or distortion of the elastic pad 30 during installation and use, and also reducing the displacement of the elastic pad 30 caused by the change of internal and external pressure during use. Moreover, the alignment tolerance of the cavity opening 3001 of the elastic pad 30 and the effective area 201 in the first direction X and the second direction Y can be ensured, avoiding the risk of the elastic pad 30 pressing the effective area 201 after the cover 20 is closed relative to the base 10. Ensuring the above alignment tolerance also helps to automate the process and reduces the problem of manual intervention caused by large positional deviation. It can be understood that the initial thickness of the elastic pad 30 can be greater than the distance between the bottom surface 2330 of the second accommodating groove 233 and the slide 200, so that the elastic pad 30 is compressed and deformed when the cover 20 is closed relative to the base 10. By adjusting the distance between the bottom surface of the second accommodating groove 233 and the slide 200 or adjusting the thickness of the elastic pad 30, the compression amount of the elastic pad 30 after compression can be controlled, so that the reaction cavity C can still maintain good sealing under different temperature changes.

[0112] As shown in FIG. 8 to FIG. 10, in some embodiments, the base portion 15 is provided with at least one base opening 150 corresponding to the effective area 201. Therefore, the temperature control device 4 can extend into and contact the slide 200 through the base opening 150, thereby directly conducting heat to the effective area 201 that needs to be heated or cooled.

[0113] In use, the slide 200 is first mounted on the base 10, and the elastic pad 30 is mounted on the cover 20. Then, the shaft portion 210 of the cover 20 is inserted into the slot 1110 of the base 10, and the first clasp 111 is inserted into the first clasp slot 211, and the chamfer 212 provided on the fifth side wall 21 is used to avoid the connecting platform 18 of the base 10. Then, the cover 20 is rotated around the shaft portion 210, so that the first inclined surface 220 abuts against the fourth clasp surface 1212, until the second clasp 121 is inserted into the second clasp slot 221, at this time, the cover 20 is closed relative to the base 10, so that the elastic pad 30 is compressed to form a plurality of independent reaction cavities C. In disassembly, the sixth side wall 22 is pried by a finger or another tool inserted into the operation space, so that the second clasp 121 is disengaged from the second clasp slot 221, so that the cover 20 is opened relative to the base 10. Since the elastic pad 30 has a restoring potential, it can act on the cover 20 to facilitate the opening of the cover 20 relative to the base 10, and then the cover 20 is rotated around the shaft portion 210 to completely separate the cover 20 from the base 10.

[0114] Referring to FIG. 12, another embodiment of the present application provides a carrier assembly 2a, which is different from the above-mentioned carrier assembly 2 in that the cover opening 2001 and the cavity opening 3001 are both square matching the effective area 201, thereby reducing the consumption of the reagent in the reaction cavity C, and also allowing the reagent to be gathered directly above the effective area 201.

[0115] Referring to FIG. 13, still another embodiment of the present application provides a carrier assembly 2b, which is different from the above-mentioned carrier assembly 2 in that when the number of effective areas 201 on the slide 200 is one, the number of cover openings 2001 and cavity openings 3001 is also one. At this time, when the slide 200 is placed in the support carrier 100 to form the carrier assembly 2b, the support carrier 100 is used to define a larger reaction cavity C on the slide 200.

[0116] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application and not to limit it. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced equivalently without departing from the spirit and scope of the technical solutions of the present application.

Claims

1. A support vehicle, characterized by, The utility model relates to a reaction device, comprising: a base configured to support a carrier, the carrier having at least one active area; a cover configured to be detachably rotatably connected to the base, the cover being openable and closable relative to the base, the cover having at least one cover opening configured to at least partially overlap the active area in a thickness direction of the carrier when the cover is closed relative to the base; and a resilient pad having at least one cavity opening, the resilient pad being configured to elastically abut between the cover and the carrier when the cover is closed relative to the base, the cavity opening being at least partially overlapped with the cover opening in the thickness direction and having one side sealed by the carrier to form a reaction cavity. The base comprises a base portion, a first sidewall, a second sidewall and a third sidewall, the first sidewall, the second sidewall and the third sidewall being connected to the base portion, at least the base portion, the first sidewall, the second sidewall and the third sidewall collectively defining a first receiving groove for receiving the carrier, the first sidewall, the second sidewall and the third sidewall being configured to collectively limit the carrier in the first receiving groove in a first direction and a second direction, the first direction, the second direction and the thickness direction being perpendicular to each other.

2. The support vehicle of claim 1, wherein, The cover comprises a cover portion and a fifth sidewall, the cover opening being provided on the cover portion, the fifth sidewall being connected to the cover portion, the fifth sidewall being configured to be detachably rotatably connected to the first sidewall. The first sidewall is provided with a first abutting member protruding towards the first receiving groove in the first direction, the first abutting member being configured to rigidly abut the carrier.

3. The support vehicle of claim 2, wherein, The first abutting member comprises a first arc-shaped convex surface, the first abutting member being configured to abut the carrier via the first arc-shaped convex surface.

4. The support vehicle of claim 3, wherein, The first sidewall and the second sidewall are oppositely arranged in the first direction, the third sidewall being connected to the first sidewall and the second sidewall, the second sidewall being provided with a second abutting member protruding towards the first receiving groove in the first direction, the second abutting member being configured to elastically abut the carrier.

5. The support vehicle of any one of claims 2 to 4, wherein, The second abutting member is an elastic arm connected to the second sidewall, the elastic arm having a connecting end connected to the second sidewall and a free end separated from the second sidewall, the free end being configured to move close to the second sidewall to generate a restoring potential energy of the elastic arm, the free end being further configured to elastically abut the carrier under the action of the restoring potential energy.

6. The support vehicle of claim 5, wherein, The free end comprises a second arc-shaped convex surface, the free end being configured to abut the carrier via the second arc-shaped convex surface.

7. The support vehicle of claim 6, wherein, ​ 8. The support vehicle of any one of claims 2 to 7, wherein, The first side wall comprises a first clasp protruding away from the first accommodating groove in the first direction, the first clasp comprises a first clasp surface and a second clasp surface oppositely arranged in the thickness direction, the first clasp surface is farther away from the cover than the second clasp surface, and the first clasp surface is provided with a slot; The fifth side wall comprises a shaft portion rotatably arranged in the slot, and the fifth side wall is further provided with a first clamping groove, and the first clasp is configured to extend into the first clamping groove when the cover is gradually closed relative to the base.

9. The support vehicle of claim 8, wherein, The base further comprises a fourth side wall, the third side wall and the fourth side wall are oppositely arranged in the second direction, the first side wall, the second side wall, the third side wall and the fourth side wall are arranged around the edge of the base portion, and the base portion, the first side wall, the second side wall, the third side wall and the fourth side wall jointly define the first accommodating groove, the fourth side wall extends beyond the base portion in the first direction to form a side protrusion, and the base further comprises a connecting platform arranged between the side protrusion and the base portion. The corner of the fifth side wall is provided with a first chamfer, and the first chamfer is configured to avoid the connecting platform when the first clasp extends into the first clamping groove.

10. The support vehicle of claim 8, wherein, The first side wall and the second side wall are oppositely arranged in the first direction, the third side wall is connected to the first side wall and the second side wall, the second side wall comprises a second clasp, the second clasp is arranged to protrude away from the first accommodating groove in the first direction, the second clasp comprises a third clasp surface and a fourth clasp surface oppositely arranged in the thickness direction, and the third clasp surface is farther away from the cover than the fourth clasp surface. The cover further comprises a sixth side wall connected to the cover portion, the fifth side wall and the sixth side wall are oppositely arranged in the first direction, the sixth side wall is provided with a second clamping groove, and the second clasp is configured to extend into the second clamping groove when the cover is gradually closed relative to the base, so that the third clasp surface abuts against the groove wall of the second clamping groove.

11. The support vehicle of claim 10, wherein, The fourth clasp surface is an arc-shaped convex surface, the surface of the sixth side wall facing the fifth side wall is provided with a first inclined surface, the first inclined surface is inclined relative to the plane defined by the first direction and the thickness direction, and the first inclined surface is configured to abut against the fourth clasp surface when the cover is gradually closed relative to the base.

12. The support vehicle of claim 11, wherein, The sixth side wall is configured to open and close relative to the cover portion by a predetermined angle, the thickness of the fifth side wall is greater than the thickness of the sixth side wall, and the thickness of the cover portion is greater than the thickness of the sixth side wall.

13. The support vehicle of claim 11 or 12, wherein, The surface of the second side wall away from the first side wall is provided with a second inclined surface, the second inclined surface is inclined relative to the plane defined by the first direction and the thickness direction, and the first inclined surface and the second inclined surface are respectively inclined away from each other and jointly define an operation space.

14. The support vehicle of any one of claims 2 to 12, wherein, The cover further comprises a boss protruding from the surface of the cover portion away from the base portion, and the cover opening further penetrates the boss.

15. The support vehicle of claim 14, wherein, The cover opening of the cover disposed on the boss has a first opening edge and a second opening edge, the first opening edge is farther away from the cover portion than the second opening edge, and the first opening edge is disposed around the second opening edge.

16. The support vehicle of any one of claims 2 to 15, wherein, The elastic pad is detachably disposed on a surface of the cover portion facing the base portion, the cover portion has a first surface facing the base portion and a second surface facing away from the first surface, the first surface is provided with a second receiving groove configured to accommodate part of the elastic pad, the cover opening penetrates a bottom surface of the second receiving groove and the second surface, and the cover opening communicates with the second receiving groove.

17. The support vehicle of claim 16, wherein, The cover further includes a positioning column protruding from a bottom surface of the second receiving groove, and the elastic pad is provided with a positioning groove, the positioning column being configured to extend into the positioning groove.

18. The support vehicle of any one of claims 2 to 17, wherein, The base portion is provided with at least one base opening, and the base opening is configured to at least partially overlap the effective area in the thickness direction.

19. The support vehicle of any one of claims 1 to 18, wherein, The cover opening is configured to cover the entire effective area in the thickness direction, and the cover opening includes a first opening part overlapping the effective area and a second opening part outside the effective area.

20. The support vehicle of claim 19, wherein, The cover opening and the cavity opening are both hexagons in the thickness direction, the first opening part is a square, and the second opening part has two triangular shapes.

21. The support vehicle of any one of claims 1 to 20, wherein, The cover opening and the cavity opening are both convex polygons in the thickness direction.

22. The support vehicle of claim 1, wherein, The base is made of at least one of polyether ether ketone and polyether imide, the cover is made of polypropylene, and the elastic pad is made of at least one of silica gel, rubber, and ethylene-propylene rubber.

23. A carrier assembly comprising a carrier sheet having at least one active area thereon, wherein, The carrier assembly further includes the support carrier according to any one of claims 1 to 22, the carrier wafer is disposed on the base of the support carrier, and the elastic pad is elastically supported between the cover and the carrier wafer.

24. A biochemical substance analysis system characterized by comprising: The carrier assembly includes the carrier assembly according to claim 23. The carrier assembly includes the carrier assembly according to claim 23.

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