Fully automated card-type blood sample extraction device

Abstract

A fully automated card-type blood sample extraction device, comprising an analysis module (10) and a gripping module (20), wherein an outlet (211) is provided at the bottom of the gripping module (20), and an inlet (111) in communication with the outlet (211) is provided at the top of the analysis module (10); the gripping module (20) comprises an upper case (21), a material box (22) arranged in the upper case (21), and a gripping mechanism (23); the analysis module (10) comprises a lower case (11), a support (17) arranged in the lower case (11), a test card conveying mechanism (12) arranged on the support (17), a detection mechanism (13) and an elution mechanism (14); the elution mechanism (14) comprises a first sealing joint (142) and a second sealing joint (143), which are arranged front and rear; a first flow channel (145) is provided inside the first sealing joint (142), and a first cavity (1451) in communication with the first flow channel (145) is formed at the rear end of the first sealing joint; a second flow channel (146) is provided inside the second sealing joint (143), and a second cavity (1461) in communication with the second flow channel (146) is formed at the front end of the second sealing joint; and when two cavities are brought together, an elution cavity (147) is formed, thereby facilitating rapid elution of a blood sample on a test card (9) and reducing test costs.

Description

A fully automatic card type blood sample extraction device TECHNICAL FIELD

[0001] The present application relates to the technical field of experimental instruments, in particular to a fully automatic card type blood sample extraction device. BACKGROUND

[0002] Dried blood spot (DBS) is a mature and advanced blood collection and preservation method, that is, a drop of blood from a fingertip or heel is dropped on a filter paper card, and after drying for more than 2 hours at room temperature, the preparation is completed, and then the storage and transportation at room temperature can be realized. In recent years, the dried blood spot technology has overcome the problems of high blood storage requirements and component transformation, and has enhanced the stability of compounds in biological samples, so that blood samples can be stored and transported at room temperature for a long time. As a good alternative to liquid blood sample collection, DBS has been widely used in clinical fields such as clinical disease marker detection, drug monitoring, pharmacokinetic research, and fields such as metabolomics, doping screening and forensic identification. The existing detection equipment needs to punch the blood sample spot on the card test paper down first when detecting DBS, then add a solvent to extract the sample, and after mixing and centrifugation, a liquid sample is prepared, and then separated and analyzed by liquid chromatography mass spectrometry. The process is complicated, the material cost is high, and the time is long.

[0003] SUMMARY

[0004] The purpose of the present application is to provide a fully automatic card type blood sample extraction device, which can conveniently and quickly elute the blood sample on the detection card online, and save the detection cost.

[0005] The purpose of the present application can be achieved by the following technical solutions:

[0006] The application discloses a full-automatic card type blood sample extraction device which comprises an analysis module and a grabbing module arranged on the analysis module; an outlet is formed in the bottom of the grabbing module, an inlet is arranged on the top of the analysis module and communicates with the outlet, and a detection card channel is formed between the outlet and the inlet; the grabbing module comprises an upper box body, a plurality of material boxes for storing detection cards arranged at the bottom of the upper box body and a grabbing mechanism for grabbing the detection cards; the analysis module comprises a lower box body, a support arranged in the lower box body, a detection card conveying mechanism arranged on the support, a detection mechanism for detecting the position of the blood sample on the detection card, an elution mechanism for eluting the blood sample on the arrived detection card with the blood sample, and a drying system for drying the detection card after the elution; the elution mechanism comprises a first sealing joint and a second sealing joint which are arranged in front of and behind each other, a gap is formed between the first sealing joint and the second sealing joint for the detection card to pass through, a sealing joint driving motor is arranged behind the second sealing joint and drives the second sealing joint to move towards the first sealing joint, a first flow channel is arranged in the first sealing joint, a first cavity which communicates with the first flow channel is formed at the rear end of the first sealing joint, a second flow channel is arranged in the second sealing joint, and a second cavity which communicates with the second flow channel is formed at the front end of the second sealing joint; the first flow channel, the first cavity, the second flow channel and the second cavity are coaxially arranged, the opening sizes of the two cavities are the same, and the two cavities form an elution cavity when the two cavities are close to each other.

[0007] According to the technical scheme, during operation, the detection card with the blood sample is conveyed to the gap between the first sealing joint and the second sealing joint, the two cavities form an elution cavity when the two cavities are close to each other, and the blood sample on the detection card is located in the elution cavity. Then, the elution liquid flows into the second flow channel, passes through the elution cavity and flows out of the first flow channel, so that the blood sample is separated from the detection card, and the detection process is accelerated.

[0008] In the embodiment of the application: the volume of the first cavity is larger than that of the second cavity, the first cavity is in a conical shape, and the second cavity is in a flat shape. According to the structure, since the second cavity is in a flat shape and has a small volume, the second cavity can be quickly filled with the elution agent, so that the elution agent can fully contact the blood sample on the detection card; the first cavity is in a conical shape and has a larger volume, so that a pressure difference is formed between the first cavity and the second cavity, the permeation of the elution liquid is promoted, the flowability of the liquid passing through the detection card is enhanced, and the blood sample is more easily separated from the detection card.

[0009] In the embodiment of the application: a heating element is further arranged in the lower box body, the drying system, the heating element, the first sealing joint and the second sealing joint are connected through the same control pipeline, and a flow control valve for controlling switching is further connected to the control pipeline.

[0010] In the embodiment of the present application: the upper box is provided with an electric rotating disc at the bottom, and a plurality of material boxes are distributed on the electric rotating disc at intervals; the grabbing mechanism comprises a gripper, a gripper lifting assembly for driving the gripper to lift, a gripper longitudinal shifting assembly for driving the gripper to longitudinally shift, and a gripper transverse shifting assembly for driving the gripper to transversely shift.

[0011] In the embodiment of the present application: the detection card conveying mechanism comprises a clamp below the inlet, a clamp shifting assembly for driving the clamp to transversely shift, and a clamp lifting assembly for driving the clamp to lift.

[0012] In the embodiment of the present application: the clamp lifting assembly comprises a U-shaped frame hingedly connected to the bracket at the middle portion, and a driving motor at the rear portion of the U-shaped frame for driving the tail of the U-shaped frame to lift.

[0013] In the embodiment of the present application: the clamp shifting assembly comprises a support seat fixed to the front end of the U-shaped frame, a motor fixed to the support seat, and a belt pulley, two belt pulleys are fixed to the two ends of the support seat, a belt is sleeved on the two belt pulleys, one of the two belt pulleys is connected with the motor through a rotating shaft, the clamp is fixedly connected with the belt, a plurality of guide wheels are arranged on the support seat, the belt passes through all the guide wheels in sequence, the clamp is fixedly connected with the belt at the front end of the U-shaped frame, a transverse guide rail is fixed in front of the belt on the support seat, a transverse sliding block is slidably connected to the transverse guide rail, and the clamp is fixed to the transverse sliding block.

[0014] In the embodiment of the present application: the elution mechanism further comprises an elution bracket, the first sealing joint is installed on the elution bracket through a first connecting piece, and the second sealing joint is installed on the elution bracket through a second connecting piece.

[0015] In the embodiment of the present application: the first connecting piece comprises a first fixed block and a first clamping block, the first fixed block is fixed to the bottom surface of the elution bracket, the bottom surface of the first fixed block is provided with a transverse blind groove, the first clamping block is installed in the blind groove, a first clamping hole is formed in the first clamping block, and the first sealing joint is installed in the first clamping hole.

[0016] In the embodiment of the present application: the second connecting piece comprises a second fixed block and a second clamping block, the second fixed block is fixed to the bottom surface of the elution bracket at the rear side of the first fixed block, the bottom surface of the second fixed block is provided with a longitudinal sliding groove, the second clamping block is slidably arranged in the sliding groove, a second clamping hole is formed in the second clamping block, and the second sealing joint is installed in the second clamping hole.

[0017] In summary, the first flow channel is arranged in the first sealing joint, and the first cavity is formed in the rear end and communicated with the first flow channel. The second flow channel is arranged in the second sealing joint, and the second cavity is formed in the front end and communicated with the second flow channel. When the two cavities are close to each other, an elution cavity is formed. When the blood sample on the detection card is located in the elution cavity, the eluent flows into the elution cavity from the second flow channel, flows out of the first flow channel through the elution cavity, and makes the blood sample quickly separate from the detection card, thereby accelerating the elution process, and the structure is simple and the cost is saved. BRIEF DESCRIPTION OF DRAWINGS

[0018] The application will be further described below in combination with the drawings.

[0019] Fig. 1 is a structural schematic diagram of a full-automatic card-type blood sample extraction device according to the application;

[0020] Fig. 2 is a structural schematic diagram of an analysis module according to the application;

[0021] Fig. 3 is a structural schematic diagram of a grabbing mechanism according to the application;

[0022] Fig. 4 is a structural schematic diagram of an upper box according to the application;

[0023] Fig. 5 is a structural schematic diagram of an analysis module according to the application;

[0024] Fig. 6 is a structural schematic diagram of a detection card conveying mechanism according to the application;

[0025] Fig. 7 is a structural schematic diagram of an elution mechanism according to the application;

[0026] Fig. 8 is a diagram showing that the detection card is conveyed to the gap between the first sealing joint and the second sealing joint;

[0027] Fig. 9 is a diagram showing that the two cavities are close to each other to form an elution cavity, and the blood sample on the detection card is located in the elution cavity;

[0028] Fig. 10 is a structural schematic diagram of the first sealing joint according to the application;

[0029] Fig. 11 is a structural schematic diagram of the second sealing joint according to the application;

[0030] Fig. 12 is a structural schematic diagram of the detection card according to the application;

[0031] Fig. 13 is a structural schematic diagram of the first connecting piece according to the application;

[0032] Fig. 14 is a structural schematic diagram of the quick-change mechanism according to the application;

[0033] Fig. 15 is an exploded view of the first connecting piece according to the application;

[0034] Fig. 16 is a structural schematic diagram of the second connecting piece according to the application;

[0035] Figure 17 is a flow chart showing the eluent. DETAILED DESCRIPTION

[0036] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative effort belong to the scope of protection of the present application.

[0037] Please refer to Figure 1, the present application is a kind of full-automatic card formula blood sample extraction equipment, including analysis module 10 and can be detachedly arranged on the analysis module and grab module 20.

[0038] In combination with Figure 2, wherein the grab module 20 includes an upper box 21, a plurality of material boxes 22 for storing detection cards 9 as shown in Figure 12 arranged in the upper box 21, and a grabbing mechanism 23 for grabbing the detection cards 9.

[0039] An electric turntable 24 is arranged at the bottom of the upper box 21, and a plurality of material boxes 22 are distributed at equal intervals on the electric turntable 24. In the present embodiment, the number of material boxes 22 is four. An outlet 211 is opened at the bottom of the upper box 21 in front of the electric turntable 24. Each material box 22 is provided with a plurality of grooves at equal intervals, and a plurality of detection cards 9 are inserted into the corresponding grooves. By using the above technical solution, when the detection cards with blood samples in the current material box are all eluted, the electric turntable 24 rotates to rotate the next material box 22 to the lower side of the grabbing mechanism 23 to perform new elution operation.

[0040] In combination with Figure 3, the grabbing mechanism 23 includes a jaw bracket 231 fixed in the upper box 21, a jaw longitudinal movement assembly 232 fixed on the jaw bracket 231, a horizontal sliding seat 233 installed on the output end of the jaw longitudinal movement assembly 232, a jaw transverse movement assembly 236 fixed on the horizontal sliding seat 233, a jaw lifting assembly 234 installed on the output end of the jaw transverse movement assembly 236, a lifting sliding seat 235 installed on the output end of the jaw lifting assembly 234, and a jaw 238 driven to open and close by a jaw cylinder 237 installed on the lifting sliding seat 235.

[0041] In the present embodiment, the jaw lifting assembly 234, the jaw longitudinal movement assembly 232 and the jaw transverse movement assembly 236 are all linear modules driven by servo motors.

[0042] As shown in FIG. 4 and FIG. 5, the analysis module 10 comprises a lower box 11, a support 17 arranged at the bottom of the lower box 11, a detection card conveying mechanism 12 arranged on the support 17, a detection mechanism 13 for detecting the blood sample position on the detection card 9, and an elution mechanism 14 for eluting the blood sample on the arrived detection card 9 with elution liquid.

[0043] The top of the lower box 11 is provided with an inlet 111 communicating with an outlet 211, and a detection card channel is formed between the outlet 211 and the inlet 111.

[0044] As shown in FIG. 6, the detection card conveying mechanism 12 comprises a clamp 121 below the inlet 111, a clamp translation assembly 122 for driving the clamp to translate horizontally, and a clamp lifting assembly 123 for driving the clamp to lift.

[0045] The clamp lifting assembly 123 comprises a U-shaped frame 1232 hingedly connected to the support 17 at the middle, and a driving motor 1233 arranged at the rear of the U-shaped frame 1232 for driving the tail of the U-shaped frame 1232 to lift.

[0046] The clamp translation assembly 122 comprises a support seat 1221 fixed to the front end of the U-shaped frame 1232, a horizontal motor 1222 fixed to the support seat 1221, and two belt pulleys 1223. The two belt pulleys 1223 are fixed to the two ends of the support seat 1221. A belt 1224 is sleeved on the two belt pulleys 1223, and one of the two belt pulleys 1223 is connected to the horizontal motor 1222 through a rotating shaft. A plurality of guide wheels 1225 are arranged on the support seat 1221, and the belt 1224 passes through all the guide wheels 1225 in sequence. The clamp 121 is fixedly connected to the belt 1224 at the front end of the U-shaped frame. A horizontal guide rail 1226 is fixed to the front of the belt 1224 on the support seat 1221, and a horizontal sliding block 1227 is slidingly connected to the horizontal guide rail 1226. The clamp 121 is fixed to the horizontal sliding block 1227. The clamp 121 has a first stop position and a second stop position when being driven to translate horizontally. The first stop position is when the clamp 121 is directly below the inlet 111, and the second stop position is when the clamp 121 is at the elution mechanism.

[0047] In addition, vertical guide rails 15 are arranged on both sides of the support seat 1221 at the bottom of the support 17, and vertical sliding blocks 16 are slidingly connected to the vertical guide rails 15. The two ends of the support seat 1221 are fixedly connected to the corresponding vertical sliding blocks 16.

[0048] A first sensor 124 is arranged near the tail of the U-shaped frame 1232. A second sensor 125 and a third sensor 126 are respectively arranged on the inner side of the left and right sides of the support base 1221. All the sensors are electrically connected to the controller (not shown in the figure). When the clamp 121 is in the first stop position, the third sensor 126 detects the clamp 121 and transmits a signal to the controller, which controls the driving motor 1233 to start and drive the tail of the U-shaped frame 1232 to descend. When the first sensor 124 detects the tail of the U-shaped frame 1232 (i.e. the tail of the U-shaped frame 1232 is in a low position, and the front end of the U-shaped frame 1232 is in a high position after rising), the driving motor 1233 stops, and then the controller controls the clamp jaw 238 to descend and insert the detection card 9 into the clamp 121. Subsequently, the controller controls the driving motor 1233 to drive the tail of the U-shaped frame 1232 to slightly rise, so that the front end of the U-shaped frame 1232 slightly descends, and the clamp 121 slightly descends. Then, the transverse motor 1222 starts to drive the clamp 121 to move to the second stop position, and then the second sensor 125 detects the clamp 121 and transmits a signal to the controller, which controls the transverse motor 1222 to stop, and then the next action is performed.

[0049] The detection mechanism 13 includes a camera light source 131 arranged behind the first stop position and a detection camera 132 arranged behind the camera light source 131. The detection camera 132 and the camera light source 131 are electrically connected to the controller.

[0050] As shown in FIGS. 7, 8 and 13, the elution mechanism 14 includes an elution support 141, a first tight joint 142 and a second tight joint 143 arranged in front and behind the elution support 141. The first tight joint 142 and the second tight joint 143 have a gap for the detection card 9 to pass through.

[0051] As shown in FIGS. 7, 13 and 16, the first tight joint 142 is installed on the elution support 141 through the first connecting piece 40. The second tight joint 143 is installed on the elution support 141 through the second connecting piece 50.

[0052] As shown in Figs. 13, 14 and 15, the first connecting member 40 comprises a first fixed block 41 and a first clamping block 42. The first fixed block 41 is fixed on the bottom surface of the elution bracket 141. The first clamping block 42 is installed on the bottom surface of the first fixed block 41. The bottom surface of the first fixed block 41 is provided with a transverse blind groove 46. The blind groove 46 has an open end and a closed end. In this way, when the first clamping block 42 is installed in the blind groove 46, the inner end of the first clamping block 42 is stopped by the closed end of the blind groove 46. A first clamping hole 44 is formed in the middle of the first clamping block 42. The position below the first clamping hole 44 has a first slit 442 which is in communication with the first clamping hole 44. A first bolt hole 445 which penetrates the first slit 442 is provided on the lower part of the first clamping block 42, and a first locking bolt 446 is arranged in the first bolt hole 445. During assembly, the first sealing head 142 is inserted into the first clamping hole 44, and the first locking bolt 446 is tightened, so as to lock and fix the first sealing head 142.

[0053] As shown in Figs. 14 and 15, the open end of the blind groove 46 is provided with a quick change mechanism 60 for facilitating replacement of the first clamping block 42.

[0054] The quick change mechanism 60 comprises a pressing block 61, a stop block 62 and a pin 63. The front surface of the first fixed block 41 is provided with an integrated mounting seat 64 near the open end of the blind groove 46. The mounting seat has a transverse groove 641 and a horizontally arranged sliding hole 642 which penetrates the transverse groove 641. The sliding hole 642 is in communication with the blind groove 46. The transverse groove 641 is a stepped groove, and the bottom has a step. The pressing block 61 is inserted into the transverse groove 641, and the inner end surface of the horizontal part 611 of the pressing block 61 has a gap with the side wall surface opposite to the groove opening of the transverse groove 641. The lower horizontal part 611 of the pressing block 61 is in contact with the step. The stop block 62 is inserted into the sliding hole 642 and is located between the two horizontal parts 611 of the pressing block 61. The stop block 62 is provided with a waist-shaped hole 621. The waist-shaped hole 621 has a first position 622 and a second position 623. The two horizontal parts 611 of the pressing block 61 are symmetrically provided with pin holes 612. The pin 63 is located in the waist-shaped hole 621, and the upper and lower ends thereof penetrate the corresponding pin holes 612 respectively, and the lower end is stopped by the step of the bottom of the transverse groove 641.

[0055] When the pin 63 is located at the first position of the waist-shaped hole 621, the inner end of the stopper 62 extends into the blind slot 46 and abuts against the end of the first clamping block, and the outer end is located in the sliding hole 642; when the pressing block 61 is pressed, the pressing block 61 moves to force the pin 63 to move from the first position 622 to the second position 623, the outer end of the stopper 62 extends out of the sliding hole 642, and the inner end is retracted into the sliding hole 642, so that the inner end of the stopper 62 does not contact the first clamping block 42 and does not stop the first clamping block 42, thereby enabling the first clamping block 42 to be disassembled from the opening end of the blind slot 46. With this structure, not only can the first sealing joint 142 be conveniently and quickly disassembled, but also sufficient space can be left for replacing the second sealing joint 143, thereby facilitating the replacement of the second sealing joint 143.

[0056] As shown in FIGS. 7 and 16, the second connecting piece 50 includes a second fixed block 51 and a second clamping block 52. The second fixed block 51 is fixed to the bottom surface of the elution support 141. The bottom surface of the second fixed block 51 is provided with a longitudinal sliding groove 55. The second clamping block 52 is slidingly arranged in the longitudinal sliding groove 55. The second clamping block 52 is provided with a second clamping hole 53 at the middle position. A second slit 532 is opened below the second clamping hole 53 and communicates with the second clamping hole 53. A second bolt hole 533 is provided at the lower part of the second clamping block 52 and penetrates the second slit 532. A second locking bolt 534 is arranged in the second bolt hole 533. During assembly, the second sealing joint 143 is arranged in the second clamping hole 53, and the second locking bolt 534 is tightened, so as to lock and fix the second sealing joint 143.

[0057] The elution support 141 is fixed with a sealing joint driving motor 144 for driving the second sealing joint 143 to move towards the first sealing joint 142.

[0058] As shown in FIGS. 9, 10 and 11, the first gasket 142 is provided with a first flow channel 145, and a first cavity 1451 is formed at the rear end of the first gasket 142 and communicates with the first flow channel 145. The second gasket 143 is provided with a second flow channel 146, and a second cavity 1461 is formed at the front end of the second gasket 143 and communicates with the second flow channel 146. The first flow channel 145, the first cavity 1451, the second flow channel 146 and the second cavity 1461 are coaxially arranged. The two cavities have the same opening size, and when the two cavities are close to each other, an elution cavity 147 is formed. With the above structure, the test card with blood sample is conveyed to the gap between the first gasket 142 and the second gasket 143, and when the two cavities are close to each other, the elution cavity 147 is formed, and the blood sample on the test card is located in the elution cavity 147. Then, the eluent flows into the second flow channel, through the elution cavity and flows out of the first flow channel, so that the blood sample is separated from the test card, which avoids the prior art that the blood sample spot on the test card is first punched down, then the solvent is added to extract the sample, and after mixing and centrifugation, the liquid sample is prepared, and then the liquid chromatography mass spectrometry is used for separation and analysis, so that the detection process is greatly accelerated.

[0059] In the embodiment, the volume of the first cavity 1451 is greater than the volume of the second cavity 1461. The first cavity 1451 is conical, and the second cavity 1461 is flat. With the structure, since the second cavity is flat and has a small volume, the second cavity can be quickly filled with eluent, so that the eluent and the blood sample can be fully contacted. The first cavity is conical and has a larger volume, so that a pressure difference is formed between the first cavity and the second cavity, the penetration of the eluent is promoted, the flowability of the liquid through the test card is enhanced, and the blood sample is more easily separated from the test card.

[0060] As shown in FIGS. 9, 10 and 11, the front end surface of the second gasket 143 is provided with an annular boss 147. The rear end surface of the first gasket 142 is provided with an annular notch 148 matched with the boss 147. With the structure, the test card 9 can be clamped more tightly, and the sealing effect is good.

[0061] As shown in Fig. 17, the drying system 30 and the heating element 32 are also installed on the base plate 171. The delivery pump 7, the detection instrument 6 and the collection bottle 5 are also arranged outside the lower box 11. The delivery pump 7, the drying system 30, the heating element 32, the first sealing joint 142, the second sealing joint 143, the detection instrument 6 and the collection bottle are all connected to a control pipeline 8. In this way, the eluent is delivered pneumatically by the delivery pump 7, enters the elution chamber from the second flow channel, elutes the blood sample on the detection card 9, and then flows out from the first flow channel. The eluent with the blood sample is detected by the detection instrument 6, and then the waste liquid is controlled to flow into the collection bottle 5 by the switching valve 4 connected to the control pipeline 8. The flow-through valve 31 is also arranged on the control pipeline 8 to control the switching of the air path or the water path. The part of the control pipeline located at the rear side of the second flow channel is heated by the heating element, so that the eluent passing through is heated. In this way, the elution of the blood sample on the detection card is easier. After the elution of the blood sample on the detection card is completed, the hot air generated by the drying system 30 is controlled to switch by the flow-through valve 31. The hot air blows into the second flow channel 145, passes through the elution chamber 147, blows out from the first flow channel 146, and enters the collection bottle 5. The current detection card 9 is blown dry by the hot air, so that too much eluent is not left on the detection card, the detection card can be recycled, the control pipeline can also be blown dry, and the residual eluent can be emptied.

[0062] The full-automatic card-type blood sample extraction equipment of the present application works as follows. During operation, the rotary motor drives the electric turntable 24 to rotate, and a magazine 22 is conveyed to below the grabbing mechanism 23 as the current magazine 22. Then, the jaw lifting assembly 234, the jaw longitudinal moving assembly 232, the jaw transverse moving assembly 236 and the jaw cylinder 237 cooperate to drive the jaw 238 to clamp the detection card 9 with the blood sample at the front of the magazine 22. At this time, the clamp 121 waiting at the first stop position is detected by the third sensor 126, and a signal is transmitted to the controller. Then, the controller controls the driving motor 1233 to start, and drives the tail of the U-shaped frame 1232 to descend. When the first sensor 124 detects the tail of the U-shaped frame 1232, the tail of the U-shaped frame 1232 is at the low position, and the front end of the U-shaped frame 1232 is at the high position after rising. The driving motor 1233 stops. Then, the controller controls the jaw lifting assembly 234, the jaw longitudinal moving assembly 232 and the jaw transverse moving assembly 236 to cooperate to insert the current detection card 9 into the clamp 121 from the outlet 211 to the inlet 111, and the jaw cylinder 237 drives the jaw 238 to release the current detection card 9.

[0063] Subsequently, the driving motor 1233 drives the slightly tail of the U-shaped frame 1232 to rise, so that the front end of the U-shaped frame 1232 slightly drops. Then, the detection camera 132 scans the current detection card 9. The detection camera 132 transmits the photographed photo to the controller, and after the controller intelligently identifies the blood sample position on the detection card 9 in the photo, the controller controls the clamp lifting assembly 123 and the clamp translation assembly 122 to cooperate, drives the clamp 121 to clamp the current detection card 9 to move to the gap between the first sealing head 142 and the second sealing head 143, and the blood sample on the detection card 9 is just located between the first cavity 1451 and the second cavity 1461. Subsequently, the sealing head driving motor 144 drives the second sealing head 143 to translate towards the first sealing head 142 until abutting with the first sealing head 142, and the two cavities are abutted together to form an elution cavity 147. Subsequently, through the pneumatic conveying of the conveying pump, the eluent flows from the second flow channel 146, into the elution cavity 147, and out of the first flow channel 145, so as to separate the blood sample from the detection card, and the eluent with the blood sample flows into the detection instrument for detection. Subsequently, the switching valve 4 is switched to make the waste liquid flow into the collection bottle 5. Then, the flow valve 31 is controlled to switch, the hot air generated by the drying system blows into the second flow channel 146, passes through the elution cavity 147, blows out of the first flow channel 145, and enters the collection bottle, so as to dry the current detection card 9, blow dry the control pipeline, and empty the residual eluent.

[0064] Subsequently, the sealing head driving motor 144 drives the second sealing head 143 to retreat to the initial position, and the clamp lifting assembly 123 and the clamp translation assembly 122 cooperate to drive the clamp 121 to clamp the current detection card 9 to move to below the inlet 111. Subsequently, the claw lifting assembly 234, the claw longitudinal translation assembly 232, the claw transverse translation assembly 236 and the claw air cylinder 237 cooperate to drive the claw 238 to clamp the current detection card 9 and put it back into the original partition groove 221 of the magazine 22. Subsequently, the next detection card 9 with blood sample is successively grabbed to continue the above steps. In this way, the continuous elution operation of the detection cards 9 with blood sample is realized.

[0065] As described above, the first flow channel is arranged in the first sealing head, and the first cavity communicated with the first flow channel is formed at the rear end. The second flow channel is arranged in the second sealing head, and the second cavity communicated with the second flow channel is formed at the front end. When the two cavities are abutted together, an elution cavity is formed. When the blood sample on the detection card is just located in the elution cavity, the eluent flows from the second flow channel, passes through the elution cavity, and flows out of the first flow channel, so as to quickly separate the blood sample from the detection card, thereby speeding up the detection process, and the structure is simple and cost-saving.

[0066] The above has been described in detail one embodiment of the present application, but the content is only the preferred embodiment of the present application, cannot be considered for limiting the scope of the present application. Any equivalent changes and improvements made in the scope of the present application, should still belong to the scope of the present application.

Claims

1. A fully automatic card type blood sample extraction device, comprising an analysis module and a grabbing module arranged on the analysis module; the bottom of the grabbing module is provided with an outlet, the top of the analysis module is provided with an inlet communicated with the outlet, and a detection card channel is formed between the outlet and the inlet; characterized in that, The grabbing module comprises an upper box, a plurality of material boxes for storing detection cards arranged at the bottom of the upper box, and a grabbing mechanism for grabbing the detection cards; the analysis module comprises a lower box, a support arranged in the lower box, a detection card conveying mechanism arranged on the support, a detection mechanism for detecting the blood sample position on the detection card, an elution mechanism for eluting the blood sample on the arrived detection card with the blood sample, and a drying system for drying the detection card after elution; the elution mechanism comprises a first sealing joint and a second sealing joint arranged in front and back, and a gap is arranged between the first sealing joint and the second sealing joint for the detection card to pass through; a sealing joint driving motor is arranged behind the second sealing joint and drives the second sealing joint to move towards the first sealing joint; a first flow channel is arranged in the first sealing joint, and a first cavity in communication with the first flow channel is formed at the rear end; a second flow channel is arranged in the second sealing joint, and a second cavity in communication with the second flow channel is formed at the front end; the first flow channel, the first cavity, the second flow channel and the second cavity are coaxially arranged; the opening sizes of the two cavities are the same, and the two cavities form an elution cavity when they are close together.

2. The fully automated card-based blood sample extraction device according to claim 1, characterized in that, The volume of the first cavity is greater than that of the second cavity, the first cavity is conical, and the second cavity is flat.

3. The fully automated card-based blood sample extraction device of claim 1, wherein, A heating element is further arranged in the lower box; the drying system, the heating element, the first sealing joint and the second sealing joint are connected through the same control pipeline; and a flow valve for controlling switching is further connected to the control pipeline.

4. The fully automated card-based blood sample extraction apparatus according to claim 1, characterized in that, An electric rotating disc is arranged at the bottom of the upper box; a plurality of material boxes are arranged at equal intervals on the electric rotating disc; the grabbing mechanism comprises a gripper, a gripper lifting assembly for driving the gripper to lift, a gripper longitudinal shifting assembly for driving the gripper to longitudinally shift, and a gripper transverse shifting assembly for driving the gripper to transversely shift.

5. The fully automated card-based blood sample extraction apparatus according to claim 1, characterized in that, The detection card conveying mechanism comprises a clamp below the inlet, a clamp shifting assembly for driving the clamp to transversely shift, and a clamp lifting assembly for driving the clamp to lift.

6. The fully automated card-based blood sample extraction device according to claim 5, characterized in that, The clamp lifting assembly comprises a U-shaped frame hingedly connected to the support at the middle and a driving motor arranged at the rear of the U-shaped frame for driving the tail of the U-shaped frame to lift.

7. The fully automated card-based blood sample extraction apparatus according to claim 5, characterized in that, The clamp shifting assembly comprises a support seat fixed to the front end of the U-shaped frame, a motor fixed to the support seat, and two belt pulleys; the two belt pulleys are fixed to the two ends of the support seat; one of the two belt pulleys is connected to the motor through a rotating shaft; the clamp is fixedly connected to the belt; a plurality of guide wheels are arranged on the support seat; the belt passes through all the guide wheels in sequence; the clamp is fixedly connected to the belt at the front end of the U-shaped frame; a transverse guide rail is fixed to the front of the belt on the support seat; a transverse sliding block is slidably connected to the transverse guide rail; and the clamp is fixed to the transverse sliding block.

8. The fully automated card-based blood sample extraction apparatus according to claim 1, characterized in that, The elution mechanism further comprises an elution support; the first sealing joint is arranged on the elution support through a first connecting piece; and the second sealing joint is arranged on the elution support through a second connecting piece.

9. The fully automated card-based blood sample extraction device according to claim 8, characterized in that, The first connecting piece comprises a first fixed block and a first clamping block, the first fixed block is fixed on the bottom surface of the elution support, the bottom surface of the first fixed block is provided with a transverse blind groove, the first clamping block is installed in the blind groove, a first clamping hole is formed in the first clamping block, and the first sealing joint is installed in the first clamping hole.

10. The fully automated card-based blood sample extraction device of claim 8, wherein, The second connecting piece comprises a second fixed block and a second clamping block, the second fixed block is fixed on the bottom surface of the elution support and located at the rear side of the first fixed block, the bottom surface of the second fixed block is provided with a longitudinal sliding groove, the second clamping block is slidingly arranged in the sliding groove, a second clamping hole is formed in the second clamping block, and the second sealing joint is installed in the second clamping hole.

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