Dialysate regeneration system and dialysis device

Abstract

Provided is a dialysate regeneration system, comprising: an effluent passage, with an input end configured for receiving a dialysis effluent; a reactor, arranged in the effluent passage and configured for decomposing toxins in the dialysis effluent, wherein the reactor comprises: a cavity provided with an inlet for receiving the dialysis effluent and an outlet for discharging a reaction liquid, and a membrane provided with a first side and a second side and arranged in the cavity, wherein an enzyme is provided on the first side or the second side of the membrane, the side of the membrane provided with the enzyme is in communication with the inlet, the other side is in communication with the outlet, and the dialysis effluent coming from the inlet is in full contact with the enzyme and then permeates through the membrane to the outlet, while the enzyme is retained on the side of the membrane provided with the enzyme; and a regeneration liquid pipeline, arranged in communication with the outlet and configured for receiving the reaction liquid processed by the reactor.

Description

Dialysate regeneration system and dialysis device TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a dialysate regeneration system and a dialysis device applied to the field of dialysis. BACKGROUND

[0002] The Sorbent Dialysis system was first developed by NASA for recycling urine of astronauts, and the first commercialized model REDY Machine (Regeneration of dialysate) achieved great commercial success in 1973. From 1973 to 1994, the REDY system successfully implemented 6 million hemodialysis treatments, most of which were performed at home, proving its good convenience, safety and clinical value.

[0003] The REDY system as a representative of the regeneration type dialysis device can reduce used dialysis waste liquid for reuse. Specifically, after the dialysis waste liquid passes through a specially designed adsorption column, it can be converted into regenerated liquid meeting the standard after component replenishment, and be reused for dialysis treatment. The adsorption column basically includes five layers, and the dialysis waste liquid passes through each layer in the adsorption column in a perfusion push manner from top to bottom.

[0004] The adsorption column includes a urea degradation layer, and enzymes are filled therein to decompose urea in the dialysis waste liquid. However, under the structure of the adsorption column, since the dialysis waste liquid passes through the urea degradation layer in a perfusion push manner, on the one hand, the contact between urea and enzymes is insufficient. On the other hand, there is a concentration gradient of urea in the dialysis waste liquid, and the working efficiency of enzymes at different positions of the urea degradation layer is quite different. For example, the enzymes at the most upstream position contact the urea with the highest concentration and exhibit high activity, and the enzymes at the downstream position cannot contact enough urea with sufficient concentration and lose activity seriously.

[0005] Some schemes in the related art independently form independent bins for each layer in the adsorption column, and the independent bins are connected with each other to complete the cleaning of the dialysis liquid. In the bin for removing urea, a plurality of hollow fibers are included, and urea enzymes need to be solidified outside the hollow fibers. The dialysis waste liquid flows into the hollow fibers from one end of the hollow fibers and flows out from the other end. In the process, urea and the like reacts with the solidified urea enzymes by diffusion. In this way, the flow direction of the dialysis liquid is along the inner cavity of the hollow fibers, and the urea enzymes are solidified outside the inner cavity. On the one hand, the diffusion of urea is insufficient, resulting in insufficient cleaning. On the other hand, the solidified urea enzymes still have the problem that enzymes at different positions cannot contact urea with sufficient concentration, resulting in serious loss of activity.

[0006] However, the enzyme accounts for a high proportion of the consumable cost, and therefore, excessive or insufficient use will result in a great increase in the consumable cost, greatly limiting the commercial application of the dialysate regeneration type dialysis equipment and the promotion of home dialysis. SUMMARY

[0007] In view of the above-mentioned disadvantages of the related art, the purpose of the present application is to provide a dialysate regeneration system and a dialysis equipment to overcome the technical problem of low enzyme use efficiency and cost increase caused by the structure of the dialysis column in the related art.

[0008] To achieve the above-mentioned purpose and other related purposes, the first aspect of the present application provides a dialysate regeneration system, comprising: a waste liquid passage, an input end of which receives dialysis waste liquid; a reactor, which is arranged in the waste liquid passage and is used for decomposing toxins in the dialysis waste liquid; the reactor comprises: a cavity, which has an inlet for the dialysis waste liquid to flow in and an outlet for reaction liquid to flow out; a membrane having a first side and a second side, which is arranged in the cavity, and an enzyme is arranged on the first side or the second side of the membrane; wherein the side of the membrane where the enzyme is arranged is communicated with the inlet, and the other side is communicated with the outlet, the dialysis waste liquid flowing in from the inlet fully contacts the enzyme and then flows to the outlet through the membrane, and the enzyme is intercepted on the side where the enzyme is arranged by the membrane; and a regenerated liquid pipeline, which is communicated with the outlet and is used for receiving the reaction liquid after being treated by the reactor.

[0009] The second aspect of the present application provides a peritoneal dialysis equipment, comprising: the dialysate regeneration system disclosed in the first aspect of the present application; a peritoneal dialysis pipeline, one end of which is communicated with the abdominal cavity of a human body, and the other end of which is communicated with the dialysate regeneration system; a driving device, which is arranged on the peritoneal dialysis pipeline and is used for driving the fluid to flow periodically or continuously in the peritoneal dialysis pipeline; and a control device, which is used for executing a treatment mode to periodically or continuously exchange the liquid in the peritoneal membrane of the human body.

[0010] The third aspect disclosed in the present application discloses a hemodialysis equipment, comprising: the dialysate regeneration system disclosed in the first aspect of the present application; a purification circuit, which comprises a first line with an input end communicated with a first part of a human body, and a second line with an output end communicated with a second part of a human body; a dialysis device, which is arranged on the purification circuit and is used for purifying the fluid flowing in the purification circuit, the dialysis device comprising: a dialysate output end connected with the input end of the waste liquid passage of the dialysate regeneration system; and a dialysate input end connected with the output end of the regenerated liquid pipeline of the dialysate regeneration system; a driving device, which is arranged on the first line and is located in the purification circuit, and is used for driving the fluid to flow in the purification circuit; and a control device, which is used for executing a treatment mode to purify the fluid flowing in the purification circuit and then input into the human body.

[0011] In summary, the dialysate regeneration system and dialysis device disclosed in the present application can make the dialysate fully contact with the enzyme on the side where the enzyme is located and react with the enzyme, improve the use efficiency of the enzyme, reduce the cost of consumables, and avoid the phenomenon that the toxin is not fully removed / decomposed. BRIEF DESCRIPTION OF DRAWINGS

[0012] The specific features involved in the present application are shown in the appended claims. The features and advantages of the invention involved in the present application can be better understood by referring to the exemplary embodiments described in detail below and the accompanying drawings. The drawings are briefly described as follows:

[0013] Fig. 1 shows a schematic diagram of the dialysate regeneration system in an embodiment of the present application.

[0014] Fig. 2 shows a schematic diagram of the dialysate regeneration system in another embodiment of the present application.

[0015] Fig. 3 shows a cross-sectional view of the reactor with a flat membrane in an embodiment of the present application.

[0016] Fig. 4 shows a cross-sectional view of the reactor with a hollow fiber membrane in an embodiment of the present application.

[0017] Fig. 5 shows a cross-sectional view of the reactor with a flat membrane in another embodiment of the present application.

[0018] Fig. 6 shows a cross-sectional view of the reactor with a hollow fiber membrane in another embodiment of the present application.

[0019] Fig. 7a shows a schematic diagram of the dialysate regeneration system including a first adsorption device in an embodiment of the present application.

[0020] Fig. 7b shows a schematic diagram of the dialysate regeneration system including a second adsorption device in an embodiment of the present application.

[0021] Fig. 7c shows a schematic diagram of the dialysate regeneration system including a first and a second adsorption device in an embodiment of the present application.

[0022] Fig. 8 shows a schematic diagram of the dialysate regeneration system in another embodiment of the present application.

[0023] Fig. 9 shows a schematic diagram of the peritoneal dialysis device in an embodiment of the present application.

[0024] Figures 10a to 10c show schematic views of a double lumen abdominal dialysis catheter according to the present application in different embodiments, respectively.

[0025] Figure 11 shows a schematic view of a hemodialysis apparatus according to the present application in one embodiment.

[0026] Figure 12 shows a schematic view of a hemodialysis apparatus according to the present application in a pre-dilution mode.

[0027] Figure 13 shows a schematic view of a hemodialysis apparatus according to the present application in a post-dilution mode.

[0028] Figure 14 shows a schematic view of a hemodialysis apparatus according to the present application in an HDF treatment mode in one embodiment.

[0029] Figure 15 shows a schematic view of a hemodialysis apparatus according to the present application in an HDF treatment mode in another embodiment. DETAILED DESCRIPTION

[0030] The principles and operation of the present application are explained more fully with reference to the accompanying drawings and the following detailed description. It should be understood that the description and drawings are not limiting on the scope of the application. It will be apparent to those skilled in the art that various modifications and changes can be made without departing from the scope of the present application. It is intended that the application encompass such modifications and changes as long as they fall within the scope of the appended claims. The following detailed description is not to be regarded as limiting the scope of the application, as defined by the appended claims.

[0031] It should be understood that, although the terms first, second, or third, etc. can be used herein to describe various elements or parameters, these elements or parameters should not be limited by these terms. These terms are only used to distinguish one element or parameter from another element or parameter. For example, a first side could be termed a second side, and similarly, a second side could be termed a first side without departing from the scope of the various described embodiments. As such, the terms first, second, third, etc. are used herein merely to differentiate one element or parameter from another element or parameter without necessarily limiting the order, the priority, or the importance of the elements or parameters. Similar situations also include the terms "first" and "second" used to describe a line or a portion of a line, or a first and a second portion of a line, etc.

[0032] Furthermore, as used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises", "comprising", "includes" and / or "including", when used herein, specify the presence of stated features, steps, operations, elements, components, items, and / or groups thereof, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, items, and / or groups thereof. For example, a process, method, system, product or apparatus that comprises a list of steps or units need not necessarily be limited to the steps or units clearly recited, but can include other steps or units that are not expressly listed or inherent to such processes, methods, products or apparatuses. In addition, the term "and / or", where used herein, describes association between or among multiple alternatives, that is including any and all combinations of one or more of the associated alternatives. In addition, the character " / " is used as a prefix to list items in order to facilitate the reading of the specification. In addition, in the description of embodiments of the present application, "plurality" means two or more than two. Furthermore, the terms "or" and "and / or" as used herein are to be interpreted as inclusive or meaning any one or any combination. An exception to this definition will exist only when a combination of elements, functions, steps or acts are in some way inherently mutually exclusive.

[0033] Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms used herein should be interpreted as having a meaning that is consistent with their meaning in the context of this specification and the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

[0034] The terms "treat" and "treatment" and variations thereof, refer to any reduction in the extent, frequency, or severity of one or more symptoms or signs associated with a condition.

[0035] The term "arterial blood line" refers to the fluid line in the extracorporeal circuit that carries blood from the patient to the dialyzer. The term "venous blood line" refers to the fluid line in the extracorporeal circuit that carries blood from the dialyzer to the patient.

[0036] The term "dialysis" is a type of filtration, or a process of selective diffusion through a membrane. Dialysis removes solutes of a particular range of molecular weights from a fluid to be dialyzed into a dialysate via diffusion through a membrane. During dialysis, the fluid to be dialyzed is passed over a filtration membrane, while dialysate is passed over the other side of the membrane. Dissolved solutes are transported through the filtration membrane by diffusion between the fluids. The dialysate serves to remove solutes from the fluid to be dialyzed. The dialysate can also provide enrichment for other fluids.

[0037] The term "dialyzer" refers to a cartridge or vessel having two flow paths separated by a semipermeable membrane. One flow path is for blood and one flow path is for dialysate. The membrane can be in the form of hollow fibers, flat sheet, or spiral wound or other conventional forms known to those skilled in the art. The membrane can be selected from the following materials: polysulfone, polyethersulfone, poly(methyl methacrylate), modified cellulose, or other materials known to those skilled in the art.

[0038] Relative terms such as "below" or "above" or "upper" or "lower" or "horizontal" or "vertical" can be used herein to describe a relationship of one element, layer, or region to another element, layer, or region as illustrated in the figures. It will be understood that these terms are intended to encompass different orientations of the device in addition to the orientation depicted in the figures. In the present application, the term "vertical", "horizontal", "parallel", are defined as including ±10% on the basis of standard definitions. For example, vertical generally means an angle of 90° with respect to a reference line, but in the present application, vertical means including within 80° to 100°. Unless specifically stated otherwise, comparative quantitative terms such as "greater than" and "less than" are intended to encompass the concept of "equal to". As an example, "greater than" can mean not only "greater than" in the mathematical sense, but also "equal to".

[0039] Further, the use of endpoints in the description of numerical ranges means that the numerical range is inclusive of the recited endpoints. Unless otherwise indicated, all numbers expressing quantities of components, molecular weights, etc. stated in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the specification and claims are approximations. At the very least, each numerical parameter should at least be construed in light of the number of significant digits it contains and by applying ordinary rounding techniques. Numerical parameters should therefore be construed in accordance with the number of significant figures used in framing the numerical range.

[0040] Notwithstanding that the numerical ranges and parameters setting forth the broadest scope of the application are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

[0041] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used herein, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises," "comprising," "includes," and / or "including," when used herein, specify the presence of stated features, integers, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof.

[0042] The application will be further described in conjunction with the drawings and specific embodiments. The technical solutions in the embodiments of the application are described clearly and completely. Obviously, the described embodiments are only part of the embodiments of the application, but not all the embodiments. Based on the embodiments in the application, all other embodiments and technical effects obtained by those skilled in the art without creative work are supposed to belong to the protection scope of the application. The phrase "an embodiment", "embodiment" or similar phrases mentioned in the whole specification mean that the specific features, structures or characteristics described together with the embodiments are included in at least one embodiment of the application. Therefore, in the whole specification, the appearance of the phrase "in an embodiment", "in an embodiment" and similar phrases can (but not necessarily) refer to the same embodiment.

[0043] The application discloses a dialysis liquid regeneration system for generating regenerated liquid by processing dialysis waste liquid generated in a dialysis process and then inputting the regenerated liquid into a dialysis device or a human body.

[0044] In an embodiment, the dialysis liquid regeneration system can be applied to a medical device, including but not limited to a blood purification device, an extracorporeal circulation removal system, an extracorporeal enrichment removal device, a hemodialysis device, a plasma replacement device, an extracorporeal peritoneal dialysis device, or an extracorporeal membrane oxygenation device. The blood purification device includes but is not limited to a hemodialysis (HD) device, a hemofiltration (HF) device, a hemodiafiltration (HDF) device, a hemoperfusion (HP) device, a plasma exchange (PE) device, an immunoadsorption (IA) device, a continuous blood purification (CRRT) device, a peritoneal dialysis (PD) device, and the like.

[0045] In the embodiments of the present application, the "regenerated liquid" refers to the dialysis waste liquid after part or most of the toxins or toxic molecules are removed, and the regenerated liquid is formed by supplementing beneficial or essential molecules such as potassium, calcium and magnesium, and is referred to as regenerated liquid. The regenerated liquid can be regarded as fresh dialysis liquid, and is exchanged with blood or peritoneal fluid again, and the cycle is repeated to continuously remove the toxins in the blood or peritoneal fluid, thereby achieving the treatment purpose. The dialysis equipment using this dialysis liquid regeneration mode is referred to as a dialysis liquid regeneration type dialysis machine, which includes a dialysis liquid regeneration type hemodialysis machine and a dialysis liquid regeneration type peritoneal dialysis machine. The biggest advantage of this dialysis machine is that it does not require a water source and a water treatment system, and therefore it is very small and portable, and is suitable for home hemodialysis and wearable dialysis equipment.

[0046] The dialysis liquid regeneration system provided in some embodiments of the present application includes a waste liquid passage, a reactor, and a regenerated liquid pipeline. In the following embodiments, the dialysis liquid regeneration system is mainly taken as an example of application in a peritoneal dialysis (PD) device.

[0047] Referring to FIG. 1, a schematic diagram of the dialysis liquid regeneration system in an embodiment of the present application is shown. As shown in the figure, the dialysis liquid regeneration system includes a waste liquid passage L2-1, a regenerated liquid pipeline L2-2, and a reactor 1 arranged in the waste liquid passage L2-1. The input end a1 of the waste liquid passage L2-1 receives dialysis waste liquid, and the output end of the waste liquid passage L2-1 is connected to the reactor 1 to input the dialysis waste liquid into the reactor 1. The reactor 1 decomposes the toxins in the input dialysis waste liquid, and the reaction liquid after the reaction treatment in the reactor 1 flows into the input end of the regenerated liquid pipeline L2-2. The regenerated liquid obtained by the dialysis liquid regeneration system after processing the reaction liquid is output through the output end a2 of the regenerated liquid pipeline L2-2.

[0048] The input end of the waste liquid passage can be directly connected to a waste liquid container for storing dialysis waste liquid, or can be connected to the outlet of the dialysis waste liquid of a peritoneal dialysis (PD) device, or can be connected to the outlet of the dialysis waste liquid of a hemodialysis (HD) device. It should be noted that the specific connection position and connection form of the input end of the waste liquid passage are not limited in the present application, as long as the input end of the waste liquid passage can receive dialysis waste liquid. In an example, the dialysis liquid regeneration system is applied in a peritoneal dialysis device, and the input end of the waste liquid passage is connected to the channel for outputting dialysis liquid in the peritoneal dialysis pipeline of the peritoneal dialysis device, so as to receive the dialysis waste liquid output by the peritoneal dialysis pipeline. In another example, the dialysis liquid regeneration system is applied in a hemodialysis device, and the input end of the waste liquid passage is connected to the dialysis liquid output end of the dialysis device, so as to receive the dialysis waste liquid output by the dialysis device.

[0049] In an embodiment, referring to FIG. 2, a schematic diagram of a dialysate regeneration system in another embodiment of the present application is shown. As shown in the figure, a dialysate pump 20 is arranged on the waste liquid passage, and the dialysate pump 20 is used to drive the fluid in the waste liquid passage L2-1 to flow forward or reversely. Specifically, the dialysate pump 20 is used to power the dialysis waste liquid in the waste liquid passage L2-1 to flow in a preset flow direction (forward or reverse). The dialysate pump 20 is exemplified as a peristaltic pump, a pneumatic diaphragm pump, or a pressure pump, etc.

[0050] In another embodiment, a first dialysate pump is arranged on the waste liquid passage, and a second dialysate pump is arranged on the regenerated liquid pipeline. The dialysate regeneration system changes the total amount of liquid in the dialysate regeneration system by the differential speed of the first dialysate pump and the second dialysate pump. Specifically, the speed of the second dialysate pump is different from that of the first dialysate pump, so as to increase or decrease the total amount of liquid in the dialysate regeneration system, to realize controllable and measurable ultrafiltration or filtration. When the periodic dialysis waste liquid filtration is realized, the difference in the speed of the two pumps is often periodic, or dynamically adjusted with the filtration amount or pressure.

[0051] In an embodiment, the flow rate of the fluid on the waste liquid passage is the same as the flow rate of the fluid in the regenerated liquid pipeline. In an example, the flow rate of the fluid on the waste liquid passage and the flow rate of the fluid in the regenerated liquid pipeline are both 50 mL / min-300 mL / min. For example, the flow rate of the fluid on the waste liquid passage and the flow rate of the fluid in the regenerated liquid pipeline are both 50 mL / min, 60 mL / min, 70 mL / min, 80 mL / min, 90 mL / min, 100 mL / min, 110 mL / min, 120 mL / min, 130 mL / min, 140 mL / min, 150 mL / min, 160 mL / min, 170 mL / min, 180 mL / min, 190 mL / min, 200 mL / min, 210 mL / min, 220 mL / min, 230 mL / min, 240 mL / min, 250 mL / min, 260 mL / min, 270 mL / min, 280 mL / min, 290 mL / min, or 300 mL / min.

[0052] In an embodiment, as shown in FIG. 2, a prefabricated liquid bypass L2-3 is arranged on the waste liquid passage L2-1, and the prefabricated liquid bypass L2-3 is used to pre-charge, empty, or flush the passage of the dialysate regeneration system. In this embodiment, a short circuit valve 21' is arranged in parallel with the prefabricated liquid bypass L2-3 on the waste liquid passage L2-1.

[0053] In an embodiment, the pre-prepared liquid bypass L2-3 is a system for pre-charging and emptying the purification loop, by connecting a liquid storage container (for example, the pre-prepared liquid bag 30 shown in FIG. 2, for example, a liquid bag made of medical plastic) in the dialysate regeneration system, and cooperating with the dialysate pump 20 to form a mode, or the upright or inverted state of the liquid storage container can realize the two operations of pre-charging and emptying, that is, in the pre-charging mode, the outlet of the liquid in the liquid storage container is at the low position; and in the emptying mode, the outlet of the gas in the liquid storage container is at the high position; compared with the conventional operation in the prior art, the system of the present application has simple structure, convenient operation, low learning cost, and does not require the operator to repeatedly invert the reactor for continuous circulation pre-charging, and further, the application of the system of the present application enables more scientific treatment of the pipeline and medical waste such as waste liquid after emptying.

[0054] In the embodiment, the pre-charging and emptying purification loop system includes a liquid storage container (i.e., the pre-prepared liquid bag 30 shown in FIG. 2), a circulation loop (i.e., the circulation loop formed after closing the dialysate inlet valve 22 and the regeneration liquid outlet valve 23 and opening the short circuit valve 21" in FIG. 2), and a dialysate pump 20. The liquid storage container is used to store pre-charging liquid and recover emptying waste liquid, and includes a container body and a first interface and a second interface provided on the container body for liquid or / and gas inlets and outlets. For example, the first interface and the second interface are the first interface b1 and the second interface b2 of the pre-prepared liquid bag 30 shown in FIG. 2.

[0055] In the embodiment, the liquid storage container can be switched between the upright state and the inverted state, that is, the upright state of the upright liquid storage container is upright, and the inverted state of the inverted liquid storage container is inverted. In order to more simply switch between the two states, a mechanism for uprighting or inverting the liquid storage container is further included. In an embodiment, the mechanism is, for example, a plate body or a frame body on which the liquid storage container is arranged, and the plate body or the frame body is provided with a structure for fixing the liquid storage container and a positioning structure for positioning the upright state and the inverted state, so that the liquid storage container can be stably uprighted or inverted.

[0056] In the present embodiment, the liquid storage container in the system for pre-filling and emptying the purification circuit has two working modes, i.e., in the pre-filling mode, the outlet of the liquid in the liquid storage container is at a low position; in the emptying mode, the outlet of the gas in the liquid storage container is at a high position; for example, in the pre-filling mode, the second interface is at a lower height so that the pre-filling liquid in the liquid storage container is preferentially introduced into the pipeline in the circulation circuit from the second interface, and in the emptying mode, the first interface is at a higher height so that the gas / bubbles in the liquid storage container are preferentially introduced into the pipeline in the circulation circuit from the first interface. In the present application, the switching between the pre-filling mode and the emptying mode can be achieved by adjusting the flow direction of the fluid and / or switching the liquid storage container between the upright position and the inverted position.

[0057] In some embodiments, the pre-prepared liquid bypass is, for example, the system for pre-filling and emptying the purification circuit described in the patent document CN2022108507945; in the present application, the entire content of the patent document CN2022108507945 is incorporated herein by reference.

[0058] In the embodiments of the present application, the reactor 1 arranged in the waste liquid passage L2-1 includes a cavity, a membrane having a first side and a second side, and an enzyme arranged on the first side or the second side of the membrane. Wherein, the cavity has an inlet for the dialysis waste liquid to flow in and an outlet for the reaction liquid to flow out, the membrane is arranged in the cavity, the enzyme is arranged on the first side or the second side of the membrane, the inlet for the dialysis waste liquid to flow in is communicated with the side of the membrane on which the enzyme is arranged, and the outlet for the reaction liquid to flow out is communicated with the other side of the membrane, the dialysis waste liquid flowing in from the inlet fully contacts the enzyme to form the reaction liquid, the reaction liquid flows to the outlet across the membrane under the pressure provided by the dialysis liquid pump, and the enzyme is retained on the side of the membrane on which the enzyme is arranged.

[0059] In an embodiment, the membrane can be a membrane with different geometrical shapes. In an example, the membrane includes one or more of a tubular membrane, a roll membrane, a flat membrane, and a hollow fiber membrane. Wherein, the membrane pore size of the membrane needs to meet the requirement that the enzyme can be retained on one side of the membrane while the liquid can be filtered to the other side, for example, the membrane pore size is smaller than the size of the enzyme-loaded microspheres, enzyme-loaded microparticles, or enzyme-loaded microcapsules described below. It should be noted that in the embodiment where the membrane is a flat membrane, the first side and the second side are respectively opposite sides of the flat membrane blocked by the planar structure; for example, in the embodiment where the membrane is a hollow fiber membrane, the first side is the outer side of the wall of each hollow fiber membrane, and the second side is the inner side of the wall of each hollow fiber membrane.

[0060] In an embodiment, the enzyme is configured to decompose the toxin in the dialysis waste liquid. The decomposition in the embodiments of the present application refers to catalytic decomposition or synthesis of the toxin to achieve the purpose of removing the toxin in the dialysis waste liquid, and should not be simply understood as catalytic decomposition. Depending on the different toxins that the reactor needs to decompose, the types of the enzyme are also different. As long as there is a corresponding enzyme with catalytic decomposition function or synthesis function, the concentration of any toxin in the dialysis waste liquid can be changed to achieve the purpose of removing the toxin in the dialysis waste liquid. For example, the reactor is configured to decompose urea in the dialysis waste liquid, and the corresponding enzyme is configured as urease. For another example, the reactor is configured to decompose ethanol in the dialysis waste liquid, and the corresponding enzyme is configured as ethanol oxidase which can oxidize ethanol. For another example, the reactor is configured to decompose uric acid in the dialysis waste liquid, and the corresponding enzyme is configured as uric acid oxidase which can oxidize uric acid. For another example, the reactor is configured to decompose phenylalanine in the dialysis waste liquid, and the corresponding enzyme is configured as phenylalanine deaminase which can decompose phenylalanine. It should be noted that the enzyme configured on the first side or the second side of the membrane can be one enzyme or multiple enzymes.

[0061] In an embodiment, the enzyme is configured in a free state. Compared with the enzyme in a fixed state, the enzyme in a free state can make the concentration of the toxin in the dialysis waste liquid contacted by the enzyme similar, and further solve the problem of serious activity loss due to the enzyme at different positions not being able to contact the dialysis waste liquid with sufficient concentration.

[0062] In an embodiment, the enzyme can be carried in the form of an enzyme preparation or enzyme-loaded microspheres. The enzyme-loaded microspheres are microspheres in which enzymes are immobilized, for example, urease microspheres are microspheres in which urease is immobilized. The enzyme preparation refers to a preparation containing enzymes. In another embodiment, the enzyme can also be carried in the form of enzyme-loaded microparticles or enzyme-loaded microcapsules. For example, urease microparticles are microparticles in which urease is immobilized, and urease microcapsules are microcapsules in which urease is immobilized. The enzyme carried in the form of enzyme-loaded microspheres, enzyme-loaded microparticles, enzyme-loaded microcapsules, or enzyme preparation is considered to be in a free state when its carrier is in a free state. Of course, in other embodiments, the enzyme can also exist in a free state without being attached to a carrier, and the present application does not limit whether the enzyme needs to be carried by a carrier as long as it can be free on the side.

[0063] In the embodiments of the present application, the inlet of the dialysis waste liquid is communicated with the side of the membrane where the enzyme is arranged, and the outlet of the reaction liquid is communicated with the other side of the membrane (the side where the enzyme is not arranged). In this structure, the reaction liquid after reacting with the enzyme needs to be forced to cross the membrane by pressure to flow out from the outlet on the other side. Further, after the dialysis waste liquid enters the side of the reactor where the enzyme is arranged, it can directly contact the enzyme instead of only part of the material contacting the enzyme by diffusion. In this way, the dialysis waste liquid before crossing the membrane continuously contacts the enzyme for a longer time by directly impacting the enzyme, which can avoid the phenomenon of insufficient toxin removal / decomposition caused by the fact that part of the toxin does not contact the enzyme or the contact time is short. Further, the reaction liquid of the present application directly flows out from the outlet on the other side after crossing the membrane without flowing back and forth across the membrane from the outlet on the same side as the inlet and without circulating to contact the enzyme, thereby improving the efficiency of toxin removal / decomposition. Further, the enzyme in the reactor is arranged in a free state, which can make the concentration of the toxin content in the dialysis waste liquid contacting the enzyme similar, thereby solving the problem of serious activity loss caused by the enzyme at different positions not contacting enough concentration of dialysis waste liquid. The membrane of the present application is intercepted on the side where the enzyme is arranged, which can make the enzyme continuously and efficiently decompose the toxin on the first side to avoid the problem of low toxin decomposition efficiency caused by the reduction of the enzyme amount.

[0064] In some embodiments, the enzyme in the reactor can be arranged on the first side of the membrane or on the second side of the membrane. Correspondingly, the inlet and outlet of the cavity of the reactor are arranged according to the position of the enzyme. In the following embodiments, the structure and working principle of the reactor are described in detail with the membrane being a flat membrane and a hollow fiber membrane, respectively.

[0065] In some embodiments, the enzyme is configured on the first side, which is in communication with the inlet, and the second side, which is in communication with the outlet, and the enzyme is trapped on the first side when the dialysis effluent flowing from the inlet is in sufficient contact with the enzyme on the first side and then crosses the membrane into the second side. In one example, referring to FIG. 3, which shows a cross-sectional view of a reactor having flat sheet membranes in one embodiment of the present application, as shown, the membrane 11 is a flat sheet membrane, the membrane 11 of the reactor 1 has a first side 102 and a second side 103, the enzyme 12 is configured on the first side 102, which is in communication with the inlet 100 of the cavity 10, the dialysis effluent flows from the inlet 100 into the first side 102 and is in sufficient contact with the enzyme 12, the reacted solution crosses the membrane 11 in the direction indicated by the dashed arrow, for example, under the pressure provided by the dialysis fluid pump, and is discharged from the outlet 101 of the second side 103, and the enzyme 12 is trapped on the first side 102. In another example, referring to FIG. 4, which shows a cross-sectional view of a reactor having hollow fiber membranes in one embodiment of the present application, as shown, the cavity 10 of the reactor 1 is provided with a plurality of membranes 11, the membrane 11 is a hollow fiber membrane, the hollow fiber membrane has an inner side and an outer side, the outer side of the membrane 11 is the first side 102, and the inner side of the membrane 11 is the second side 103, the enzyme 12 is configured on the first side 102, the first side 102 of each membrane 11 is in communication with each other and with the inlet 100 of the cavity 10, the dialysis effluent flows from the inlet 100 and fills the first side 102 of the plurality of membranes 11 and is in sufficient contact with the enzyme 12, the reacted solution crosses the membrane 11 in the direction indicated by the dashed arrow, for example, under the pressure provided by the dialysis fluid pump, and then flows from the port on the side of the membrane 11 close to the outlet 101 to the outlet 101, and the enzyme 12 is trapped on the first side 102. It should be noted that in the embodiment shown in FIG. 4, the end of the second side 103 (inner side) of the membrane 11 close to the inlet 100 is closed to prevent the dialysis effluent from flowing into the second side 103 from this end, the end of the second side 103 (inner side) of the membrane 11 close to the outlet 101 is open to allow the reacted solution to flow out from this end after crossing the membrane 11, and the first side 102 (outer side) of the membrane 11 is in communication with the inlet 100 and not in communication with the outlet 101, so that the dialysis effluent can only enter the first side 102 from the inlet 100, and the reacted solution can only flow out from the end of the second side 103 close to the outlet 101 after crossing the membrane 11.

[0066] In some embodiments, the enzyme is configured on the second side, which is in communication with the inlet, and the first side is in communication with the outlet, and the dialysis effluent flows into the second side from the inlet, and the enzyme is retained on the second side after the dialysis effluent is in sufficient contact with the enzyme on the second side and crosses the membrane into the first side. In one example, referring to FIG. 5, which shows a cross-sectional view of a reactor with flat membrane in another embodiment of the present application, as shown, the enzyme 12 is configured on the second side 103, which is in communication with the inlet 100 of the cavity 10, and the dialysis effluent flows into the second side 103 from the inlet 100 and is in sufficient contact with the enzyme 12, and the reacted reaction liquid crosses the membrane 11 in the direction shown by the dotted arrow, for example, under the pressure provided by the dialysis liquid pump, and is discharged from the outlet 101 of the first side 102, and the enzyme 12 is retained on the second side 103. In another example, referring to FIG. 6, which shows a cross-sectional view of a reactor with hollow fiber membrane in another embodiment of the present application, as shown, the cavity 10 of the reactor 1 is provided with a plurality of membranes 11, which are hollow fiber membranes, and the hollow fiber membranes have an inner side and an outer side, the outer side of the membrane 11 is the first side 102, and the inner side of the membrane 11 is the second side 103, and the enzyme 12 is configured on the second side 103, and the second side 103 of each membrane 11 is in communication with the inlet 100 of the cavity 10, and the dialysis effluent flows into the second side 103 after flowing into the inlet 100, and fills the second side 103 of the plurality of membranes 11, and is in sufficient contact with the enzyme 12 on the second side 103, and the reacted reaction liquid crosses the membrane 11 in the direction shown by the dotted arrow, for example, under the pressure provided by the dialysis liquid pump, and then flows from the first side 102 of the membrane 11 to the outlet 101, and the enzyme 12 is retained on the second side 103. It should be noted that in the embodiment shown in FIG. 6, one end of the second side 103 (inner side) of the membrane 11 close to the inlet 100 is opened to allow the dialysis effluent to flow into the second side 103 from this end, and one end of the second side 103 (inner side) of the membrane 11 close to the outlet 101 is closed to prevent the reaction liquid from flowing out from this end, and the first side 102 (outer side) of the membrane 11 is not in communication with the inlet 100, and is in communication with the outlet 101, so that the dialysis effluent can only enter the second side 103 from one end of the second side 103 close to the inlet 100, and the reacted reaction liquid can only enter the first side 102 after crossing the membrane 11 and flow out from the outlet 101.

[0067] In some embodiments, the inlet and the outlet are configured at a vertical angle. For example, as shown in FIGS. 3-6, the inlet 100 and the outlet 101 are both configured at a vertical angle, which can reduce pressure loss compared to the horizontal arrangement of the inlet and the outlet, and ensure sufficient pressure to promote the reaction liquid to cross the membrane 11, thereby improving the flow efficiency of the fluid.

[0068] It should be noted that although the inlet and outlet are configured at a perpendicular angle in the examples of FIGS. 3-6, the angle between the inlet and outlet is not limited in the present application. In other embodiments, the inlet and outlet can be parallel to each other or can be at an acute or obtuse angle.

[0069] It should be noted that according to the description of the working principle of the reactor in the foregoing embodiments, the reactor can be designed in various forms, and is not limited to the reactor described in the examples of FIGS. 3-6, affected by factors such as the type of membrane.

[0070] In any of the above embodiments, the enzyme located at the first side or the second side is formulated in a free state, so that the concentration of the toxin in the dialysis waste liquid contacted by the enzyme is similar, and the problem of serious activity loss due to the enzyme at different positions not being able to contact sufficient concentration of dialysis waste liquid is solved.

[0071] In an embodiment, referring to FIG. 7a, a schematic diagram of a dialysate regeneration system including a first adsorption device in an embodiment of the present application is shown. As shown in the figure, the dialysate regeneration system further includes a first adsorption device 24 configured upstream of the reactor 1, and the first adsorption device 24 is used for preliminary toxin treatment of the dialysis waste liquid. Specifically, the output end of the first adsorption device 24 is connected with the inlet of the reactor 1, so that the dialysis waste liquid subjected to preliminary toxin treatment by the first adsorption device 24 enters the reactor 1 from the inlet of the reactor 1 for deep toxin treatment. In an example, the first adsorption device 24 is mainly used for adsorbing potassium, calcium, magnesium and other ions in the dialysis waste liquid.

[0072] In some embodiments, one or more adsorption materials can be included in the first adsorption device. The adsorption materials include activated carbon, cation exchanger, or anion exchanger, etc. The cation exchanger includes zirconium phosphate, or cation exchange resin, etc., and the anion exchanger includes hydrated zirconium oxide, zirconium hydroxide, zirconium sodium carbonate, or anion exchange resin, etc. In an example, one adsorption material is included in the first adsorption device. For example, the first adsorption device only contains one activated carbon column. In another example, multiple adsorption materials are included in the first adsorption device. For example, the first adsorption device is a mixed column of activated carbon and anion exchanger. For another example, the first adsorption device is a mixed column of activated carbon and cation exchanger. For another example, the first adsorption device is a mixed column of anion exchanger and cation exchanger. For another example, the first adsorption device is a mixed column of activated carbon, anion exchanger, and cation exchanger. Among them, the activated carbon material is used for adsorbing organic substances, the cation exchanger is used for adsorbing various cationic substances including potassium, calcium, magnesium, etc., and the anion exchanger is used for adsorbing various anionic substances such as phosphate, acetate, etc. In the following embodiments, the first adsorption device is configured with multiple materials as an example for description.

[0073] In one embodiment, as shown in Figure 7a, the first adsorption device 24 is configured as a single mixed column containing a plurality of adsorption materials. The first adsorption device 24 includes a plurality of layers of materials designed to remove contaminants and uremic solutes while preserving the proper composition of dialysate. Waste dialysate flows from downstream to upstream through the first adsorption device 24. The layers in contact with the dialysate contain activated carbon. These layers adsorb heavy metals, chloramines and other contaminants that can be found in tap water. In addition, activated carbon adsorbs many of the organic and middle molecule uremic solutes found in waste dialysate, including creatinine and uric acid. The plurality of layers of materials includes a layer of zirconium phosphate and is a cation exchange layer. Its primary function is to adsorb ammonium ions produced by the hydrolysis of urea. In addition, this cation exchange material adsorbs other positively charged species, such as magnesium, calcium and potassium, as well as heavy metal cations, such as copper and iron, that can be found in tap water. For the adsorbed cations, the zirconium phosphate releases sodium or potassium in exchange. The plurality of layers of materials also includes a layer of anion exchange material containing hydrous zirconium oxide. This material adsorbs phosphate, fluoride and other anions, such as the oxide anions of heavy metals, and releases water or hydroxide anions in exchange. It should be understood that the upstream and downstream relationship is determined by the direction of fluid flow, with the first flow being upstream and the last flow being downstream, and not the physical spatial relationship, which is generally from the bottom to the top of the column, so the adsorption material in the downstream is often in the upper layer.

[0074] In another embodiment, the first adsorption device includes a plurality of columns in series, such as a column containing zirconium phosphate, a column containing hydrous zirconium oxide, and a column containing activated carbon material, arranged in series. It should be noted that the present application does not limit the number of columns in series in the first adsorption device, which can include two or more columns, and each column can include one or more adsorption materials.

[0075] In this embodiment, one or more of a pressure sensor, a degassing device, and a pH sensor can be provided between the plurality of columns in series.

[0076] In another embodiment, as shown in FIG. 7b, a schematic diagram of a dialysate regeneration system including a second adsorption device in an embodiment of the present application is shown. As shown, the dialysate regeneration system further includes a second adsorption device 25, the input end of which is connected to the outlet of the reactor 1, in other words, the second adsorption device 25 is located downstream of the reactor 1, for further toxin treatment of the waste liquid after urea decomposition in the reactor. For example, the second adsorption device 25 is mainly used for adsorbing toxins such as creatinine, phosphate, ammonium ions formed after urea decomposition, and also adsorbing potassium, calcium, magnesium ions, etc. In some embodiments, one or more adsorption materials can also be included in the second adsorption device. In embodiments where the second adsorption device is configured with multiple adsorption materials, the second adsorption device can be configured as a single mixed column containing multiple adsorption materials, or can be configured as a plurality of columns connected in series, wherein each column contains one or more adsorption materials. The material composition of the second adsorption device is the same as or similar to the above examples of the first adsorption device, and will not be described in detail here. The size of the column, the filling ratio of the adsorption material, and the filling amount of the adsorption material can be the same as or different from the first adsorption device, for example, the column of the second adsorption device is larger than the column of the first adsorption device.

[0077] In yet another embodiment, as shown in FIG. 7c, a schematic diagram of a dialysate regeneration system including a first and second adsorption device in an embodiment of the present application is shown. As shown, the dialysate regeneration system includes the first adsorption device and the second adsorption device to enhance the removal effect of toxins.

[0078] In an embodiment, as shown in FIG. 1, the regeneration liquid pipeline L2-2 is connected to the outlet of the reactor 1 for receiving the reaction liquid after reaction treatment in the reactor 1, and the output end of the regeneration liquid pipeline can be directly connected to a regeneration liquid container for storing the regeneration liquid, or can be connected to the inlet of the regeneration liquid of a peritoneal dialysis (PD) device, or can be connected to the inlet of the regeneration liquid of a hemodialysis (HD) device. It should be noted that the present application does not limit the specific connection position and connection form of the output end of the regeneration liquid pipeline, as long as the output end of the regeneration liquid pipeline has an inlet or device that can receive the regeneration liquid. In an example, the dialysate regeneration system is applied in a peritoneal dialysis device, and the output end of the regeneration liquid pipeline is connected to a peritoneal dialysis pipeline in the peritoneal dialysis device for inputting the regeneration liquid into the peritoneal dialysis pipeline for a channel for inputting the regeneration liquid. In another example, the dialysate regeneration system is applied in a hemodialysis device, and the output end of the regeneration liquid pipeline is connected to the dialysate input end of a dialysis device in the hemodialysis device for inputting the regeneration liquid into the dialysis device.

[0079] In an embodiment, as shown in FIG. 2 and FIG. 8, the dialysate regeneration system of the present application is provided with a make-up fluid branch L2-4 for delivering make-up fluid to the regeneration fluid line L2-2. Specifically, the make-up fluid branch L2-4 is configured to deliver make-up fluid to the regeneration fluid line L2-2 to form regenerated fluid that can be used for dialysis treatment.

[0080] In an embodiment, as shown in FIG. 2 and FIG. 8, the dialysate regeneration system of the present application is provided with a make-up fluid branch L2-4 for delivering make-up fluid to the regeneration fluid line L2-2. Specifically, the make-up fluid branch L2-4 is configured to deliver make-up fluid to the regeneration fluid line L2-2 to form regenerated fluid that can be used for dialysis treatment.

[0081] In an embodiment, the hypertonic solute solution includes glucose. In an example, the glucose in the hypertonic solute solution is configured at a concentration ranging from 1.5% to 70%. For example, the glucose in the hypertonic solute solution is configured at a concentration of 1.5%, 2%, 2.5%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, or 70%.

[0082] In an embodiment, the electrolyte solution is configured to include potassium, calcium, and magnesium, for example, the make-up fluid is a potassium, calcium, and magnesium concentrate. In an example, the concentration of potassium, calcium, and magnesium in the electrolyte solution is configured to range from 0 to 100 mmol / L. For example, the total concentration of potassium, calcium, and magnesium in the electrolyte solution is configured to range from 0, 10 mmol / L, 20 mmol / L, 30 mmol / L, 40 mmol / L, 50 mmol / L, 60 mmol / L, 70 mmol / L, 80 mmol / L, 90 mmol / L, or 100 mmol / L. Further, in an embodiment, the electrolyte solution further includes magnesium, sodium, chloride, base, etc.

[0083] In some embodiments, a temperature control device is further provided in the waste fluid passage and / or the regeneration fluid line. The temperature control device is configured to control the temperature of the fluid in the waste fluid passage and / or the regeneration fluid line within a preset range. For example, the temperature control device is a heating device or a thermostat.

[0084] In some embodiments, a leak sensor is provided in the waste fluid passage. In an embodiment, a pressure sensor is provided in the waste fluid passage to detect the pressure of the dialysis waste fluid. Further, a hydrophobic filter is further provided between the waste fluid passage and the pressure sensor, and the permeability of the hydrophobic filter is configured to allow the pressure sensor to detect the pressure of the dialysis waste fluid in the waste fluid passage.

[0085] The present application also provides a peritoneal dialysis device for dialysis treatment, which comprises a peritoneal dialysis line, a driving device, a control device, and a dialysate regeneration system in communication with the peritoneal dialysis line. In order to distinguish the control device and the driving device of the peritoneal dialysis device from the control device and the driving device of the hemodialysis device described later, the control device and the driving device of the peritoneal dialysis device are referred to as the first control device and the first driving device, respectively, and the control device and the driving device of the hemodialysis device are referred to as the second control device and the second driving device, respectively.

[0086] Referring to FIG. 9, a schematic diagram of the peritoneal dialysis device in an embodiment of the present application is shown. As shown in the figure, the peritoneal dialysis device comprises a peritoneal dialysis line L1, a first driving device 51, a first control device 52, and a dialysate regeneration system in communication with the peritoneal dialysis line L1. One end of the peritoneal dialysis line L1 is in communication with the abdominal cavity 50 of a human body, and the other end is in communication with the dialysate regeneration system. The first control device 52 executes a treatment mode to control the first driving device 51 to drive the fluid to flow periodically or continuously in the peritoneal dialysis line L1, so that the peritoneal dialysis line L1 inputs the dialysis waste liquid in the abdominal cavity of the human body to the dialysate regeneration system and receives the regenerated liquid generated by the dialysate regeneration system, thereby achieving the periodic or continuous exchange of the liquid in the peritoneum of the human body.

[0087] The communication mode of the dialysate regeneration system and the working principle are as described in the foregoing embodiments with respect to FIGS. 1 to 8 and their related descriptions, which will not be repeated here.

[0088] In some embodiments, the peritoneal dialysis line comprises two single-channel peritoneal catheters or one double-channel peritoneal catheter. In an example, the peritoneal catheter is configured as a single channel, and the peritoneal dialysis line comprises two single-channel peritoneal catheters, one of which is used to output the dialysis waste liquid, and the other of which is used to input the regenerated liquid, in other words, the channel of one peritoneal catheter is in communication with the input end of the waste liquid passage, and the channel of the other peritoneal catheter is in communication with the output end of the regenerated liquid line. In another example, the peritoneal catheter is configured as a double channel, specifically, one peritoneal catheter comprises two channels. One channel is used to output the dialysis waste liquid, and the other channel is used to input the regenerated liquid; in other words, one channel is used to communicate with the input end of the waste liquid passage, and the other channel is used to communicate with the output end of the regenerated liquid line. For ease of illustration, the channel for outputting the dialysis waste liquid is referred to as the first channel, and the channel for inputting the regenerated liquid is referred to as the second channel. In the following embodiments, the peritoneal catheter is configured as a double channel.

[0089] Please refer to FIG. 10a to FIG. 10c, which respectively show schematic diagrams of the double-channel peritoneal dialysis catheter in different embodiments of the present application. As shown in the figures, the first channel L1-1 and the second channel L1-2 of the peritoneal dialysis catheter can be configured in a parallel manner as shown in FIG. 10a, or can be configured at an acute angle as shown in FIG. 10b, or can be configured at 180 degrees as shown in FIG. 10c.

[0090] In an embodiment, after the double-channel peritoneal dialysis catheter is placed in the abdominal cavity, the regenerated fluid can enter from the second channel, and the dialysis waste fluid flows out from the first channel. In this way, the fluid flow into the abdominal cavity and the fluid flow out of the abdominal cavity can be kept the same, and thus the peritoneal dialysis device can be implemented in the CFPD (continuous flow peritoneal dialysis) mode.

[0091] In an embodiment, as shown in FIG. 9, the peritoneal dialysis pipeline L1 is further provided with a dialysis fluid pipeline L3, which is in communication with the peritoneal dialysis pipeline L1 and is used for inputting dialysis fluid into the abdominal cavity 50. It should be noted that during the process of inputting dialysis fluid into the abdominal cavity 50, the end of the peritoneal dialysis pipeline L1 for outputting dialysis waste fluid (the dialysis waste fluid outlet of the peritoneal dialysis pipeline L1) is closed, and after the inputting of dialysis fluid is completed, i.e., the preset input amount is reached, the dialysis fluid pipeline L3 is closed, and the regenerated fluid inlet and the dialysis waste fluid outlet of the peritoneal dialysis pipeline L1 are opened. It should be noted that in order to achieve the above process, the dialysis fluid pipeline L3 can be provided with a pump for driving the dialysis fluid to flow into the abdominal cavity, and the peritoneal dialysis pipeline L1 can be provided with a valve that can realize pipeline conduction and closure.

[0092] After the dialysis fluid is input into the abdominal cavity 50 of the human body, the first driving device 51 provided on the peritoneal dialysis pipeline L1 can drive the fluid to flow periodically or continuously in the peritoneal dialysis pipeline L1. In an example, the first driving device 51 continuously drives the dialysis waste fluid to flow from the dialysis waste fluid outlet of the peritoneal dialysis pipeline L1 into the waste fluid passage L2-1 of the dialysis fluid regeneration system, and the dialysis waste fluid forms regenerated fluid after being decomposed by the dialysis fluid regeneration system. The regenerated fluid flows from the regenerated fluid pipeline L2-2 of the dialysis fluid regeneration system into the regenerated fluid inlet of the peritoneal dialysis pipeline L1, so that the fluid continuously flows in the peritoneal dialysis pipeline L1. In another example, the first driving device 51 periodically drives the dialysis waste fluid to flow from the dialysis waste fluid outlet of the peritoneal dialysis pipeline L1 into the waste fluid passage L2-1 of the dialysis fluid regeneration system, so as to realize the periodic flow of the fluid in the peritoneal dialysis pipeline L1.

[0093] The first driving device 51 comprises one or more pumps arranged on the peritoneal dialysis pipeline L1, which are used to provide power to the fluid in the pipeline to make the fluid flow in a preset direction. In an embodiment, the pump can be a peristaltic pump, a pneumatic diaphragm pump, or a pressure pump. In this application scenario for medical purposes, the first driving device 51 should not directly contact the fluid, but only apply pressure to the pipeline and drive the fluid to flow. The preferred solution of the first driving device 51 is a non-contact pump device such as a peristaltic pump or a pneumatic diaphragm pump. The forward rotation and reverse rotation (reversal) of the peristaltic pump can make the flow direction of the fluid in the peritoneal dialysis pipeline L1 different.

[0094] When the dialysate regeneration system is arranged in the peritoneal dialysis device, the first driving device can also simultaneously serve as the dialysis pump of the dialysate regeneration system, that is, the dialysate pump arranged on the waste liquid passage can be replaced by the first driving device. In other embodiments, the dialysate pump can also be arranged in the dialysate regeneration system on the basis of the first driving device to improve the driving effect on the fluid.

[0095] The first control device 52 is used to execute a treatment mode to periodically or continuously exchange the liquid in the human peritoneum. In an embodiment, the first control device 52 is, for example, a controller or a system processor of the peritoneal dialysis device, which outputs corresponding control instructions through a program written in the system processor; or accepts the trigger instructions input by an operator through an input device such as a touch screen to execute the related control instructions. In the treatment mode, the peritoneal dialysis device can periodically or continuously exchange the liquid in the human peritoneum. Specifically, the peritoneal dialysis device can continuously suck the dialysis waste liquid from the human abdominal cavity and continuously input the regenerated liquid into the human abdominal cavity through the control of the periodic flow or continuous flow of the fluid to achieve dialysis.

[0096] In some embodiments, the peritoneal dialysis device is configured as a combination of one or more of the CAPD treatment mode, the APD treatment mode, the TPD treatment mode, and the CFPD treatment mode. In an example, the peritoneal dialysis device can be configured as only the CAPD treatment mode, the APD treatment mode, the TPD treatment mode, or the CFPD treatment mode. In another example, the peritoneal dialysis device is configured as a combination of multiple treatment modes such as the CAPD treatment mode, the APD treatment mode, the TPD treatment mode, and the CFPD treatment mode. For example, the peritoneal dialysis device comprises a mode selection device for receiving an input mode selection signal to send determined working mode information to the first control device to execute the work corresponding to the working mode, so that the peritoneal dialysis device can realize the combination of multiple treatment modes.

[0097] In a specific embodiment, the peritoneal dialysis device is configured in a CFPD mode, and the peritoneal dialysis catheter is configured in a double channel. When the intraperitoneal dialysis fluid reaches a required amount, one channel of the peritoneal dialysis catheter continuously outputs dialysis waste fluid, and the other channel continuously inputs regenerated fluid. Thus, the fluid flow into the abdominal cavity and the fluid flow out of the abdominal cavity can be kept the same, and the peritoneal dialysis device can be implemented in a CFPD (continuous flow peritoneal dialysis) mode.

[0098] It should be noted that, although the CAPD treatment mode, the APD treatment mode, the TPD treatment mode, and the CFPD treatment mode are taken as examples for illustration in the embodiments of the present application, the peritoneal dialysis device can also be configured in other periodic or continuous treatment modes in other embodiments.

[0099] The peritoneal dialysis device of the present application can achieve the effect of using a small amount of dialysis fluid to perform dialysis by recycling and regenerating the dialysis waste fluid. For example, the present application can achieve the dialysis effect of using 48 L of dialysis fluid in the APD or CAPD mode after 8 hours of treatment in the present application using 1 L of dialysis fluid. In addition, the peritoneal dialysis device of the present application does not require a water source and a water treatment system, and thus is very small and portable, suitable for home dialysis and wearable dialysis devices.

[0100] In an embodiment, referring to FIG. 11, a schematic diagram of a hemodialysis device in an embodiment of the present application is shown. As shown in the figure, the hemodialysis device includes a dialysis device 61, a second driving device 60, a second control device 62, a purification circuit, and a dialysis fluid regeneration system. The second control device 62 controls the second driving device 60 to drive the fluid to flow in the purification circuit, the dialysis device 61 purifies the fluid flowing in the purification circuit and inputs the generated dialysis waste fluid into the dialysis fluid regeneration system, and the dialysis fluid regeneration system purifies the dialysis waste fluid and inputs it into the human body through the purification circuit.

[0101] The input end of the waste fluid passage L2-1 of the dialysis fluid regeneration system is connected to the dialysis device 61 to obtain the dialysis waste fluid from the dialysis device 61. Specifically, the input end of the waste fluid passage L2-1 is connected to the dialysis fluid output end 610 of the dialysis device 61 to obtain the dialysis waste fluid output by the dialysis fluid output end 610. The output end of the regenerated fluid passage L2-2 can be connected to the dialysis fluid input end 611 of the dialysis device 61 to input the regenerated fluid into the dialysis device 61.

[0102] The connection mode and working principle of the dialysis fluid regeneration system are as described above for the embodiments of FIGS. 1 to 8, and will not be described again here.

[0103] The purification circuit includes a first line L4, i.e. an arterial blood line, connected to a first part of the human body at an input end, and a second line L5, i.e. a venous blood line, connected to a second part of the human body at an output end. In the treatment mode of the hemodialysis device, an arterial puncture needle is connected to the front end of the first line L4 through a connector, and a second driving device 60, e.g. a peristaltic pump, is arranged in the middle of the first line L4. On the other hand, a venous puncture needle is connected to the front end of the second line L5 through a connector, and a drip chamber / venous bottle or a gas collection chamber with the function of a venous bottle is connected in the middle of the second line L5. In addition, during the dialysis treatment, the arterial puncture needle and the venous puncture needle are respectively punctured into the target arterial blood vessel and the target venous blood vessel of the patient's body. If the second driving device 60 is in operation, the patient's blood passes through the first line L4 to the dialysis device 61, is purified by the dialysis device 61, is defoamed in the drip chamber / venous bottle, and then returns to the patient's body through the second line L5. That is, the patient's blood is circulated from the front end of the first line L4 to the front end of the second line L5, and is purified by the dialysis device 61.

[0104] The second driving device 60 is arranged on the first line L4 in the purification circuit and is used to drive the fluid to flow in the purification circuit. In an embodiment, the second driving device 60 includes but is not limited to a peristaltic pump, a pneumatic diaphragm pump, or a pressure pump, which is used to provide power to the fluid in the pipeline to make the fluid circulate in the preset flow direction. In this application scenario for medical purposes, the second driving device 60 should not directly contact the fluid, but only apply pressure to the pipeline and drive the fluid to flow. The preferred solution of the second driving device 60 is a non-contact pump device such as a peristaltic pump or a pneumatic diaphragm pump. More specifically, the peristaltic pump is, for example, a dialysis pump or a blood pump. The forward rotation and reverse rotation (reversal) of the peristaltic pump can make the flow direction of the fluid in the circulation circuit different.

[0105] It should be understood that the second driving device 60 can achieve the driving effect of the fluid in the pipeline at different positions in the pipeline. The flow rate of the fluid may

[0106] The second control device 62 is used to execute the control instruction after the treatment mode purifies the fluid flowing in the purification circuit and inputs the human body. In an embodiment, the second control device 62 is, for example, a controller or a system processor of the hemodialysis device, which outputs the corresponding control instruction by writing the program in the system processor or accepts the trigger instruction input by the operator to execute the related control instruction.

[0107] The dialysis device 61 is provided on the purification circuit and is used for purifying the fluid flowing in the purification circuit. The dialysis device 61 comprises a dialysate output end 610 and a dialysate input end 611. The dialysate output end 610 is in communication with the input end of the waste liquid passage L2-1 to input dialysis waste liquid into the waste liquid passage L2-1, and the dialysate input end 611 is in communication with the output end of the regenerated liquid pipeline L2-2 to receive the regenerated liquid input by the regenerated liquid pipeline L2-2. The dialysis device 61 can purify the fluid (blood) flowing in the purification circuit by using the regenerated liquid.

[0108] In an embodiment, the dialysis device is used for purifying the fluid (blood) flowing in the purification circuit, and forms a blood flow path for the blood flow and a dialysate flow path for the dialysate flow by using an internal purification membrane for purifying the blood. In an embodiment, the dialysis device comprises a dialysate chamber, a blood chamber and a semi-permeable membrane, etc. The membrane separates the dialysate chamber and the blood chamber from each other. In a commonly used capillary type dialysis device, the blood chamber is formed by the entire internal volume of the hollow fiber, and the dialysate chamber is formed by the internal cavity of the housing of the dialysis device surrounding the hollow fiber. In an embodiment, the top end of the dialysis device is in communication with the arterial blood line, and the bottom end of the dialysis device is in communication with the venous blood line.

[0109] In an embodiment, the dialysis device is a hemodialyzer, a hemodiafiltration device, a hemofilter, a plasma separator, or a blood plasma component separator, etc. of various specifications or purposes, and any device capable of separating the toxins or molecular components in the blood can be used in the present application. In an embodiment, the dialysis device comprises one or a combination of a hemodialysis (HD), a hemofiltration (HF), a hemodiafiltration (HDF), a hemoperfusion (HP), a plasmapheresis (PE), an immunoadsorption (IA), or a continuous renal replacement therapy (CRRT).

[0110] In some embodiments, the hemodialysis device comprises at least one detection device for detecting the concentration of the target molecules in the dialysis waste liquid, detecting the content of the enzyme-loaded microspheres in the waste liquid passage L2-1 (such as detecting the amount of enzyme-loaded microspheres added or whether the enzyme-loaded microspheres are removed), or detecting the content of the enzyme-loaded microspheres in the regenerated liquid pipeline L2-2.

[0111] In some embodiments, the hemodialysis device further comprises a mode selection device for receiving an input mode selection signal to send the determined working mode information to the second control device to perform the operation corresponding to the working mode. In this embodiment, the working mode comprises one or a combination of the HF treatment mode, the HD treatment mode, the HDF treatment mode, and the ultrafiltration mode.

[0112] In the HF treatment mode, the second control device controls the regenerated liquid outputted from the dialysate regeneration system to be directly inputted into the first line or the second line. In an embodiment, referring to FIG. 12, a schematic diagram of the hemodialysis apparatus in the present application in a pre-dilution mode is shown, as shown in the figure, the second control device 62 controls the regenerated liquid outputted from the dialysate regeneration system to be directly inputted into the first line L4, such as the arterial jug 63, and this mode of directly inputting the regenerated liquid into the arterial jug 63 can be referred to as a pre-dilution mode. In another embodiment, referring to FIG. 13, a schematic diagram of the hemodialysis apparatus in the present application in a post-dilution mode is shown, as shown in the figure, the second control device 62 controls the regenerated liquid outputted from the dialysate regeneration system to be directly inputted into the second line L5, such as the venous jug 64, and this mode of directly inputting the regenerated liquid into the venous jug 64 can be referred to as a post-dilution mode.

[0113] In the HD treatment mode, the second control device controls the regenerated liquid outputted from the dialysate regeneration system to be inputted into the dialysate input end of the dialysis device. As shown in FIG. 11, the second control device 62 controls the regenerated liquid outputted from the dialysate regeneration system to be directly inputted into the dialysate input end 611 of the dialysis device 61.

[0114] In the present application, the hemodialysis apparatus can also achieve the design of HDF treatment mode, i.e., hemodiafiltration with dynamic control of the total amount of dialysate. In an embodiment, the total amount of liquid in the dialysate circulation is controlled by dynamically and periodically regulating the volume or liquid level of any container in the dialysate circulation, so as to achieve periodic filtration and filtration, and increase the molecular convective exchange of the dialyzer.

[0115] In the HDF treatment mode, the control device controls the regenerated liquid outputted from the dialysate regeneration system to be inputted into the first line or the second line through a displacement liquid branch. The displacement liquid branch is arranged on the regenerated liquid pipeline, one end of the displacement liquid branch is communicated with the regenerated liquid pipeline, and the other end is used for communicating with the dialysis loop.

[0116] In an embodiment, referring to FIG. 14, a schematic diagram of the HDF treatment mode of the hemodialysis apparatus in an embodiment in the present application is shown, as shown in the figure, the second control device 62 controls the regenerated liquid outputted from the dialysate regeneration system to be inputted into the first line L4, such as the arterial jug 63, through the displacement liquid branch L6. This mode of directly inputting the regenerated liquid into the arterial jug 63 can be referred to as a pre-dilution mode. Among them, the displacement liquid branch L6 is provided with a displacement liquid pump 65 for delivering the regenerated liquid into the dialysis loop. Further, in an embodiment, the displacement liquid branch further includes a bacteria filter for filtering the regenerated liquid again before inputting the regenerated liquid into the dialysis loop.

[0117] In one embodiment, referring to FIG. 15, the schematic diagram of the HDF treatment mode of the hemodialysis apparatus of the present application is shown. In another embodiment of the HDF treatment mode, the second control device 62 controls the output of the regenerated liquid from the dialysate regeneration system to be input into the second line L5, such as the venous jug 64, through the substitution liquid branch L6. This mode of directly inputting the regenerated liquid into the venous jug 64 can be referred to as a post-dilution mode. In this embodiment, the substitution liquid pump 65 is arranged on the substitution liquid branch L6 for delivering the regenerated liquid into the dialysis circuit. Further, in one embodiment, a bacteria filter is arranged on the substitution liquid branch for filtering the regenerated liquid again before inputting into the dialysis circuit.

[0118] In the embodiments of the HDF treatment mode shown in FIG. 14 or FIG. 15, the second control device 62 adjusts the output of the substitution liquid branch L6 to control the molecular convection exchange amount of the dialysis apparatus 61 by periodically dynamically adjusting the liquid amount in the waste liquid passage L2-1, the reactor 1, or the regenerated liquid line L2-2. In one embodiment, the second control device 62 adjusts the output of the substitution liquid branch L6 to control the molecular convection exchange amount of the dialysis apparatus 61 by dynamically adjusting the working period or power of the dialysate pump 20 to adjust the liquid amount in the reactor 1.

[0119] In one embodiment, the second control device periodically changes the total amount of the liquid balance state of the dialysate circulation to periodically achieve the filtration and filtration of the liquid inside and outside the dialyzer. In one embodiment, in the HDF treatment mode, the total amount of the liquid balance state of the dialysate circulation is changed by adjusting the differential speed of the two dialysate pumps arranged on the first dialysate pump of the waste liquid passage and the second dialysate pump of the regenerated liquid line.

[0120] In the embodiment of the ultrafiltration mode, the dialysate regeneration system is provided with an ultrafiltration branch that diverts the dialysis waste liquid in the waste liquid passage to increase the transmembrane pressure or negative pressure, so that the dialysis device filters the same amount of liquid from the blood flowing through it into the dialysis waste liquid, thereby achieving dehydration treatment. In this embodiment, the ultrafiltration branch is provided with an ultrafiltration container for storing the ultrafiltration liquid and an ultrafiltration pump for delivering the ultrafiltration liquid in the ultrafiltration container to the waste liquid passage. In one example, the ultrafiltration container is, for example, an ultrafiltration bag, such as a liquid bag made of medical plastic; and the ultrafiltration pump can be a plunger roller pump, a peristaltic pump, or a diaphragm pump, etc.

[0121] In the embodiment of the ultrafiltration mode, the second control device controls the rotation speed or the empirical value of the ultrafiltration pump to meter the flow of the dialysis effluent in the effluent passage shunted by the ultrafiltration branch. For example, in an embodiment, the second control device controls the rotation speed of the ultrafiltration pump to meter the flow of the dialysis effluent in the effluent passage shunted by the ultrafiltration branch by obtaining the volume or weight of the regeneration fluid in the regeneration fluid line. For example, in another embodiment, the volume or weight of the regeneration fluid is obtained by weighing or liquid level metering.

[0122] In an embodiment, when the dialysate regeneration system is applied to the dialysis cycle of a blood purification apparatus, the ultrafiltration pump continuously draws water out of the effluent passage to form a transmembrane negative pressure, at which time the dialysis device will ultrafiltrate water to achieve pressure balance, and finally the ultrafiltration pump draws out as much water as the blood loses, thereby achieving the purpose of dehydration. In an actual embodiment, the ultrafiltration pump continuously draws the dialysis effluent in the effluent passage into the effluent bag, and by accurately metering the flow of the ultrafiltration pump, the excess water in the patient's body can be accurately drawn out of the body, thereby achieving the purpose of dehydration.

[0123] In another embodiment, the ultrafiltration branch can also be provided on the regeneration fluid line, i.e., the ultrafiltration branch includes a first ultrafiltration branch provided on the effluent passage and a second ultrafiltration branch provided on the regeneration fluid line. In this embodiment, a weighing type ultrafiltration control is adopted, i.e., a double pump control of an upstream pump and a downstream pump is adopted, wherein the upstream pump is provided on the first ultrafiltration branch, and the downstream pump is provided on the second ultrafiltration branch of the regeneration fluid line. The container, such as an ultrafiltration bag, in communication with the second ultrafiltration branch contains treated regeneration fluid, and a weighing device is provided below the ultrafiltration bag. The weighing device can obtain the content of the regeneration fluid in the ultrafiltration bag by weighing, and the rotation speed of the upstream pump and the downstream pump is adjusted, for example, if the water in the ultrafiltration bag exceeds the preset value (ultrafiltration curve), it means that the ultrafiltrated water is too much, and the rotation speed of the upstream pump is lowered and the rotation speed of the downstream pump is increased; conversely, if the water in the ultrafiltration bag is lower than the preset value (ultrafiltration curve), the rotation speed of the upstream pump is increased and the rotation speed of the downstream pump is lowered.

[0124] It should be noted that those skilled in the art can adaptively add corresponding pumps, valves, and / or sensors and the like according to the principle described in the embodiments of the present application. For example, valves can be respectively provided at the ends of the first line and the second line connected to the human body. For another example, a valve can also be provided on the replacement fluid branch.

[0125] In summary, the dialysate regeneration system and dialysis equipment provided by the present application, the inlet of the reactor for dialysis waste liquid is communicated with one side of the membrane where the enzyme is arranged, and the outlet of the reactor for reaction liquid is communicated with the other side of the membrane (the side where the enzyme is not arranged), under this structure, the reaction liquid after the dialysis waste liquid flows in from the inlet and reacts with the enzyme needs to be forced to cross the membrane by pressure to be able to flow out through the outlet on the other side, further making the dialysis waste liquid after entering the side with the enzyme in the reactor of the present application can directly contact with the enzyme instead of only part of the substances contacting with the enzyme by diffusion, in this way, the dialysis waste liquid before crossing the membrane continuously contacts with the enzyme for a longer time by directly impacting the enzyme, which can avoid the phenomenon of insufficient toxin removal / decomposition caused by the fact that part of the toxins cannot contact with the enzyme or the contact time is short; and the reaction liquid of the present application directly flows out from the outlet on the other side after crossing the membrane without being discharged from the outlet on the same side as the inlet through reciprocating crossing the membrane and without being contacted with the enzyme through circulating flow, thereby improving the efficiency of toxin removal / decomposition; further, the enzyme in the reactor is prepared in a free state, which can make the concentration of the toxin content in the dialysis waste liquid contacted by the enzyme similar, solving the problem of serious loss of activity caused by the fact that the enzyme at different positions cannot contact with dialysis waste liquid with sufficient concentration; the membrane of the present application is intercepted on the side where the enzyme is arranged, which can make the enzyme continuously and efficiently decompose toxins on the first side, to avoid the problem of low toxin decomposition efficiency caused by the reduction of the amount of enzyme. The regenerated liquid output from the reactor can be used for the process of dialysis again, thereby realizing the effect of using a small amount of dialysate to achieve the effect of abdominal and hemodialysis of a large amount of dialysate.

[0126] The above embodiments only exemplarily illustrate the essence of the present application and the beneficial effects obtained thereby, and are not used to limit the present application. Any person skilled in the art can modify or change the above embodiments without departing from the principles and scope of the present application. Therefore, all equivalent modifications or changes made by those skilled in the art without departing from the spirit and technical thought disclosed by the present application should be covered by the claims of the present application.

Claims

1. A dialysate regeneration system, characterized by, The application relates to a dialysate regeneration system comprising: a waste liquid passage, an input end of which receives dialysis waste liquid; a reactor arranged in the waste liquid passage for decomposing toxins in the dialysis waste liquid; the reactor comprises: a cavity having an inlet for inflow of the dialysis waste liquid and an outlet for outflow of reaction liquid; a membrane having a first side and a second side, arranged in the cavity, and enzymes arranged on the first side or the second side of the membrane; wherein the side of the membrane on which the enzymes are arranged is connected to the inlet and the other side is connected to the outlet, the dialysis waste liquid flowing from the inlet and fully contacting the enzymes before flowing across the membrane to the outlet, and the enzymes are retained on the side on which the enzymes are arranged by the membrane; a regeneration liquid pipeline connected to the outlet for receiving reaction liquid after the reaction treatment by the reactor.

2. The dialysate regeneration system of claim 1, wherein, when the enzymes are arranged on the first side, the first side is connected to the inlet and the second side is connected to the outlet, and the dialysis waste liquid flowing from the inlet fully contacts the enzymes on the first side before flowing across the membrane to the second side, and the enzymes are retained on the first side.

3. The dialysate regeneration system of claim 1, wherein, when the enzymes are arranged on the second side, the second side is connected to the inlet and the first side is connected to the outlet, and the dialysis waste liquid flowing from the inlet fully contacts the enzymes on the second side before flowing across the membrane to the first side, and the enzymes are retained on the second side.

4. The dialysate regeneration system of claim 1, wherein, the inlet and the outlet are arranged at a vertical angle.

5. The dialysate regeneration system of claim 1, wherein, the enzymes are configured as urease.

6. The dialysate regeneration system of claim 1, wherein, the enzymes arranged on the first side or the second side of the membrane are configured in a free state.

7. The dialysate regeneration system of claim 1 or 6, characterized in that the enzymes can be carried in the form of enzyme preparation or enzyme-loaded microspheres.

8. The dialysate regeneration system of claim 1, wherein, the reactor is used for decomposing urea in the dialysis waste liquid.

9. The dialysate regeneration system of claim 1, wherein, a first adsorption device arranged upstream of the reactor is further included for primary toxin treatment of the dialysis waste liquid.

10. The dialysate regeneration system of claim 1, wherein, a second adsorption device is further included, an input end of which is connected to the outlet, for secondary toxin treatment of the dialysis waste liquid after urea decomposition by the reactor.

11. The dialysate regeneration system of any of claims 9 or 10, characterized in that the first or second adsorption device is configured as a single mixed column containing multiple adsorption materials.

12. The dialysate regeneration system of any of claims 9 or 10, wherein the at least one sorbent bed is configured to remove at least one of calcium, magnesium, sodium, potassium, chloride, sulfate, and bicarbonate from the dialysate. the first or second adsorption device comprises multiple columns connected in series, and each column contains one or more adsorption materials.

13. The dialysate regeneration system of claim 9, wherein, the first adsorption device comprises one activated carbon column; or a mixed column of activated carbon and anion exchanger; or a mixed column of activated carbon and cation exchanger; or a mixed column of anion exchanger and cation exchanger; or a mixed column of activated carbon, anion exchanger and cation exchanger.

14. The dialysate regeneration system of claim 10, wherein, the second adsorption device is configured as an adsorption column containing phosphoric acid, hydrated zirconium oxide and activated carbon.

15. The dialysate regeneration system of claim 1, wherein, a dialysate pump is arranged on the waste liquid passage for driving forward or reverse flow of fluid in the waste liquid passage.

16. The dialysate regeneration system of claim 1, wherein, a first dialysate pump is arranged on the waste liquid passage, and a second dialysate pump is arranged on the regeneration liquid pipeline, for changing the liquid balance state total amount of the dialysate regeneration system by the differential speed of the first dialysate pump and the second dialysate pump.

17. The dialysate regeneration system of claim 1, wherein, a pre-prepared liquid bypass for pre-charging, emptying or flushing the passage of the dialysate regeneration system is arranged on the waste liquid passage.

18. The dialysate regeneration system of claim 1, wherein, a supplement liquid branch for delivering supplement liquid to the regeneration liquid pipeline is arranged on the regeneration liquid pipeline.

19. The dialysate regeneration system of claim 18, wherein, The supplement liquid branch is provided with a container for storing the supplement liquid, and a supplement liquid pump for delivering the supplement liquid in the container to the supplement liquid branch.

20. The dialysate regeneration system of claim 19, wherein, The supplement liquid comprises an electrolyte liquid and / or a high-osmotic-solute liquid.

21. The dialysate regeneration system of claim 20, wherein, The high-osmotic-solute liquid comprises glucose.

22. The dialysate regeneration system of claim 21, wherein, The glucose in the high-osmotic-solute liquid is configured at 1.5% to 70%.

23. The dialysate regeneration system of claim 20, wherein, The electrolyte liquid is configured to comprise potassium, calcium and magnesium.

24. The dialysate regeneration system of claim 23, wherein, The concentration of the potassium, calcium and magnesium can be configured at 0 to 100 mmol / L.

25. A peritoneal dialysis apparatus, characterized by The dialysate regeneration system of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; 26. The peritoneal dialysis apparatus of claim 25, wherein, The peritoneal dialysis device of any one of claims 1 to 24; 27. The peritoneal dialysis apparatus of claim 25, wherein, The peritoneal dialysis device of any one of claims 1 to 24; 28. The peritoneal dialysis apparatus of claim 25, wherein, The peritoneal dialysis device of any one of claims 1 to 24; 29. A hemodialysis apparatus, characterized by The peritoneal dialysis device of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; The peritoneal dialysis device of any one of claims 1 to 24; 30. The hemodialysis device of claim 29, wherein, The peritoneal dialysis device of any one of claims 1 to 24; 31. The hemodialysis device of claim 29, wherein, The peritoneal dialysis device of any one of claims 1 to 24; 32. The hemodialysis device of claim 29, wherein, The peritoneal dialysis device of any one of claims 1 to 24; 33. The hemodialysis device of claim 29, wherein, The peritoneal dialysis device of any one of claims 1 to 24; 34. 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The hemodialysis device of claim 34, wherein, In the HF treatment mode, the control device controls the regenerated liquid output by the dialysate regeneration system to be directly input into the first circuit or the second circuit.

36. The hemodialysis device of claim 34, wherein, In the HD treatment mode, the control device controls the regenerated liquid output by the dialysate regeneration system to be input into the dialysate input end of the dialysis device.

37. The hemodialysis device of claim 34, wherein, In the HDF treatment mode, the control device controls the regenerated liquid output by the dialysate regeneration system to be input into the first circuit or the second circuit through a replacement liquid branch; The replacement liquid branch is arranged on the regenerated liquid pipeline, one end of the replacement liquid branch is communicated with the regenerated liquid pipeline, and the other end is used for communicating with the dialysis loop.

38. The hemodialysis device of claim 37, wherein, In the HDF treatment mode, the control device adjusts the output of the replacement liquid branch by periodically dynamically adjusting the liquid amount in the waste liquid passage, the reactor or the regenerated liquid pipeline to control the molecular convection exchange amount of the dialysis device.

39. The hemodialysis device of claim 37, wherein, In the HDF treatment mode, the control device periodically realizes the filtration and filtration of the liquid inside and outside the dialyzer by periodically changing the total amount of the liquid balance state of the dialysate circulation.

40. The hemodialysis device of claim 39, wherein, In the HDF treatment mode, the total amount of the liquid balance state of the dialysate circulation is changed by adjusting the differential speed of the two dialysate pumps arranged in the dialysis pump of the waste liquid passage and the dialysate pump of the regenerated liquid pipeline.

41. The hemodialysis device of claim 34, wherein, In the ultrafiltration mode, the ultrafiltration branch in the dialysate regeneration system divides the dialysis waste liquid in the waste liquid passage to increase the transmembrane pressure or negative pressure, so that the dialysis device filters the same amount of liquid of the blood or peritoneal fluid passing through into the dialysis waste liquid, thereby achieving dehydration treatment.

42. The hemodialysis device of claim 41, wherein, In the ultrafiltration mode, the control device controls the rotation speed or empirical value of the ultrafiltration pump to meter the flow of the dialysis waste liquid in the waste liquid passage divided by the ultrafiltration branch.

43. The hemodialysis device of claim 42, wherein, In the ultrafiltration mode, the control device controls the rotation speed of the ultrafiltration pump to meter the flow of the dialysis waste liquid in the waste liquid passage divided by the ultrafiltration branch by obtaining the volume or weight of the regenerated liquid in the regenerated liquid pipeline.

44. The hemodialysis device of claim 43, wherein, The volume or weight of the regenerated liquid is obtained by weighing or liquid level metering.

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