Antimicrobial hydrolyzed collagen compositions and methods of using the same

A hydrolyzed collagen composition with biguanides, vicinal diols, and chelating agents addresses the lack of antimicrobial efficacy in wound care, achieving significant microbial reduction and promoting tissue healing.

WO2026080745A1 Publication Date: 2026-04-16ROCHAL TECHNOLOGIES LLC
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Patent Information

Application Number
PCT/US2025/050322
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-10-10
Filing Date
2025-10-09
Publication Date
2026-04-16

AI Technical Summary

Technical Problem

Existing wound care solutions lack effective antimicrobial properties while maintaining biocompatibility, leading to issues with infection and impaired tissue healing.

Method used

A hydrolyzed collagen composition incorporating at least one biguanide, one hydrophobic vicinal diol, and one chelating agent, which provides at least a 2-log reduction of planktonic microbes and enhances tissue healing by reducing pathogens without cytotoxicity.

Benefits of technology

The composition effectively reduces and eliminates a wide range of microbes and pathogens on wounds, tissues, and devices, promoting tissue healing and maintaining biocompatibility.

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Abstract

A composition is provided that includes hydrolyzed collagen, at least one biguanide, at least one vicinal diol, and at least one chelating agent. The composition exhibits at least 2-log reduction of planktonic microbes within 24 hours. Methods of using the composition are also provided.
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