In-vivo pressure detection sensor and detection system

Abstract

An in-vivo pressure detection sensor and detection system. The detection sensor comprises: an air pouch (1), which is configured to be implanted into a part awaiting measurement; and a first air pressure sensor (2), which is located in an environment in gas communication with the interior of the air pouch (1) and which is used for measuring the air pressure value inside the air pouch (1). By means of combining the air pouch (1) with the first air pressure sensor (2), in-vivo pressure monitoring can be implemented, thereby reducing the physical size of the detection sensor; and the air pouch (1) is used to directly measure intracranial pressure to obtain an accurate intracranial pressure value, thereby preventing the exposure of brain tissue to the risk of injury. The detection sensor further comprises a first wireless power supply and communication module (8), which is used for performing wireless power supply on internal components of the detection sensor and directly sending measured parameters to an external receiver.

Description

In vivo pressure detection sensors and detection systems Technical Field

[0001] This invention relates to the technical field of medical devices, and more particularly to pressure detection sensors and detection systems within living organisms. Background Technology

[0002] Intracranial pressure (ICP) is the pressure exerted by the contents of the cranial cavity on the walls of the cranial cavity. Increased ICP is a common manifestation of various intracranial diseases (such as traumatic brain injury, cerebral hemorrhage, and brain tumors) or secondary intracranial injuries. Dynamic and continuous monitoring of ICP is crucial for assessing the condition, guiding clinical medication, and evaluating prognosis.

[0003] In existing invasive intracranial pressure monitoring technologies, a typical device uses a miniature MEMS pressure sensing chip to directly contact brain tissue or cerebrospinal fluid for measurement. However, to achieve this direct contact measurement and ensure its long-term, stable, and safe operation in vivo, this technological approach faces significant challenges, directly resulting in the difficulty in miniaturizing the size of the sensor's core components.

[0004] The core reason for its large size lies in the fact that, to meet the requirements of biocompatibility, long-term implantation stability, and prevention of signal drift, the sensing chip must be encapsulated in an extremely robust, sealed, and bio-inert shell (such as a titanium metal package). The physical size and structural complexity of this protective "package" are often far greater than the MEMS chip itself. This complex packaging structure is not only necessary to ensure the function and safety of the device, but also inevitably results in a large physical volume of the entire sensing unit during implantation, thereby increasing the difficulty of surgical implantation, the patient's foreign body sensation, and the potential risk of pressure on surrounding tissues.

[0005] Therefore, there is an urgent need in the field for an innovative pressure sensing solution that can fundamentally avoid the reliance on complex and robust packaging structures, thereby opening up new avenues for miniaturizing implantable sensors, reducing implantation trauma, and improving patient comfort. Summary of the Invention

[0006] In view of the above problems, the present invention is proposed to provide a biological pressure detection sensor and detection system that overcomes or at least partially solves the above problems.

[0007] In a first aspect, embodiments of the present invention provide a pressure detection sensor within a biological organism, comprising:

[0008] An airbag is used to implant into the site of the test.

[0009] The first pressure sensor is located in an environment connected to the gas inside the airbag and is used to measure the pressure value inside the airbag.

[0010] In one embodiment, the airbag has a first open end;

[0011] The biological pressure detection sensor also includes:

[0012] A first housing, wherein the first pressure sensor is disposed inside the first housing;

[0013] The first housing has an open end, which is connected to the first open end of the airbag, thereby creating a gas communication state between the interior of the first housing and the airbag.

[0014] In one embodiment, the first housing has an open end, which is connected to the first open end of the airbag, thereby creating a gas communication state between the interior of the first housing and the airbag. Specifically:

[0015] A conduit is provided on the surface of the first housing, with one open end of the conduit communicating with the internal space of the first housing and the other open end communicating with the first open end of the airbag.

[0016] In one embodiment, the first housing and the conduit are integrally formed.

[0017] In one embodiment, a support component is provided, and the first housing is fixed to the support component;

[0018] The supporting component is also provided with a first microprocessor and a first wireless power supply and communication module;

[0019] The first wireless power supply and communication module is used to supply power to the first microprocessor and the first barometric pressure sensor, and to communicate with an external receiver.

[0020] The first microprocessor is used to control the working state of the first air pressure sensor, acquire the air pressure value measured by the first air pressure sensor, and perform a first preset processing on the air pressure value measured by the first air pressure sensor.

[0021] In one embodiment, the first preset process includes:

[0022] The first wireless power supply and communication module transmits the air pressure value measured by the first air pressure sensor to an external receiver.

[0023] or,

[0024] The pressure value of the part to be tested is determined based on the air pressure value measured by the first air pressure sensor, and the pressure value of the part to be tested is sent to an external receiver through the first wireless power supply and communication module.

[0025] In one embodiment, the first wireless power supply and communication module includes: a first NFC chip and a receiving coil;

[0026] The first NFC chip is used to receive energy emitted by an external receiver through the receiving coil and convert it into a preset voltage to power the first microprocessor and the first barometric pressure sensor; and to enable communication with external devices.

[0027] In one embodiment, the support component includes an integrated circuit board on which the receiving coil is disposed.

[0028] In one embodiment, a support rod is provided, one end of which passes through the first housing and is connected to the support component, and the other end extends into the airbag.

[0029] In one embodiment, when the supporting component is an integrated circuit board:

[0030] The airbag also has a second opening end, and the second opening end is provided with a heat-conducting plug.

[0031] The other end of the support rod extends through the airbag and connects to the heat-conducting plug;

[0032] A temperature sensor is installed inside the thermally conductive plug.

[0033] In one embodiment, the first microprocessor is further configured to acquire the temperature value of the part to be measured monitored by the temperature sensor, and send the temperature value of the part to be measured to an external receiver through the first wireless power supply and communication module.

[0034] In one embodiment, the biological pressure detection sensor further includes:

[0035] The second housing is used to cover and protect the support component and the components disposed on the support component.

[0036] Secondly, embodiments of the present invention provide a biological pressure detection system, including any of the above-described biological pressure detection sensors and a receiver.

[0037] The receiver includes a processor, a second wireless power supply and communication module;

[0038] The second wireless power supply and communication module is used to cooperate with the first wireless power supply and communication module of the biological pressure detection sensor to provide power to the internal components of the biological pressure detection sensor; and to communicate with the first wireless power supply and communication module of the biological pressure detection sensor to obtain the parameter values ​​measured by the biological pressure detection sensor.

[0039] The processor is used to perform a second preset processing on the parameter value.

[0040] In one embodiment, the parameter value includes the air pressure value measured by the first air pressure sensor, or the pressure value of the part to be measured;

[0041] The second preset processing includes:

[0042] When the parameter value includes the air pressure value measured by the first air pressure sensor, the pressure value of the part to be measured is determined based on the air pressure value measured by the first air pressure sensor.

[0043] In one embodiment, the second wireless power supply and communication module includes a transmitting coil and a second NFC chip.

[0044] In one embodiment, the receiver further includes a main body carrier and a transmitting coil carrier;

[0045] The processor and the second NFC chip are disposed in the main body carrier;

[0046] The transmitting coil is disposed on the transmitting coil support portion;

[0047] The main support portion and the transmitting coil support portion are separately configured;

[0048] The components on the main body support are electrically and / or signal connected to the transmitting coil on the transmitting coil support through connecting components.

[0049] In one embodiment, the connecting component is detachably electrically and / or signal-connected to components on the main body support portion;

[0050] and / or

[0051] The connecting component is detachably electrically connected and / or signal connected to the transmitting coil on the transmitting coil carrier.

[0052] In one embodiment, the receiver further includes a second barometric pressure sensor for measuring atmospheric pressure;

[0053] When the parameter value includes the air pressure value measured by the first air pressure sensor, determining the pressure value of the part to be measured based on the air pressure value measured by the first air pressure sensor includes:

[0054] When the parameter value includes the air pressure value measured by the first air pressure sensor, the pressure value of the part to be measured is determined based on the atmospheric pressure and the air pressure value measured by the first air pressure sensor.

[0055] In one embodiment, the receiver further includes at least one of a wireless communication module and a display module; wherein,

[0056] The wireless communication module is connected to the processor and is used to enable bidirectional communication between the receiver and an external terminal.

[0057] The display module is used to perform display operations according to the control of the processor.

[0058] Compared with the prior art, the present invention has at least the following beneficial effects:

[0059] By employing an airbag structure in conjunction with a pressure sensor, the size of the detection sensor is effectively reduced. The airbag structure also avoids the risk of damage caused by direct contact between the pressure sensor or other electronic components and biological tissues. The detection sensor may also include a first wireless power supply and communication module, enabling wireless power supply to the internal components and communication with external devices. This results in a highly integrated structure, eliminating the need for a battery, further reducing the sensor's size, improving the user experience, and ensuring the sensor's processing and communication performance. It also overcomes the drawback of wired detection sensors requiring continuous wound exposure, allowing the patient to suture the wound after implantation, reducing the risk of clinical infection and postoperative activity restrictions. This invention improves the ease of operation of the detection sensor and expands its application scenarios, providing real-time and reliable data for diagnosing diseases and injuries.

[0060] Other features and advantages of the invention will be set forth in the description which follows, and will be apparent in part from the description, or may be learned by practicing the invention. The objects and other advantages of the invention may be realized and obtained by means of the structures particularly pointed out in the written description, claims, and drawings.

[0061] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. Attached Figure Description

[0062] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings:

[0063] Figure 1 is a schematic diagram of the first structure of a pressure detection sensor in a biological body provided by an embodiment of the present invention.

[0064] Figure 2 is a schematic diagram of a second structure of a biological pressure detection sensor provided in an embodiment of the present invention.

[0065] Figure 3 is a schematic diagram of a third structure of a biological pressure detection sensor provided in an embodiment of the present invention.

[0066] Figure 4 is a schematic diagram of the fourth structure of a biological pressure detection sensor provided in an embodiment of the present invention.

[0067] Figure 5 is a schematic diagram of the connection of internal components of a biological pressure detection sensor provided in an embodiment of the present invention.

[0068] Figure 6 is a schematic diagram of the principle of a biological pressure detection sensor provided in an embodiment of the present invention.

[0069] Figure 7 is an overall schematic diagram of a biological pressure detection and sensing system provided in an embodiment of the present invention.

[0070] Figure 8 is a data graph of wireless power transfer test results between the transmitting coil and the receiving coil in a biological pressure detection and sensing system provided in an embodiment of the present invention.

[0071] Figure 9 is a test result data graph of a biological pressure detection and sensing system provided in an embodiment of the present invention for a water tank experimental scenario;

[0072] Figure 10 is a graph showing the nonlinear error test results of a biological pressure detection and sensing system provided in an embodiment of the present invention.

[0073] Figure 11 is a schematic diagram of the support structure of the air bladder in the biological pressure detection sensor provided in an embodiment of the present invention;

[0074] Figure 12 is another schematic diagram of the support structure of the air bladder in the biological pressure detection sensor provided in the embodiment of the present invention.

[0075] Reference numerals: 1. Airbag; 2. First air pressure sensor; 3. First housing; 4. Plug; 5. Support rod; 6. Support component; 7. First microprocessor; 8. First wireless power supply and communication module; 9. Second housing; 10. Receiving coil; 11. First NFC chip. Detailed Implementation

[0076] Exemplary embodiments of the present disclosure will now be described in more detail with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

[0077] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," "far," "near," "front," and "rear," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0078] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0079] The terms “comprising” and “having”, and any variations thereof, used in this application are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not limited to the steps or units listed, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to such process, method, product, or apparatus.

[0080] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0081] Referring to Figure 1, this is a first structure of a biological pressure detection sensor provided in an embodiment of this application. The biological pressure detection sensor includes an air bladder 1 and a pressure sensor. The air bladder 1 is implanted into the site to be measured, allowing direct contact between the air bladder 1 and the interior of the site; the site to be measured can be, but is not limited to, the ventricles of the brain, the bladder, etc. A first pressure sensor 2 is located in an environment communicating with the gas inside the air bladder 1 and is used to measure the gas pressure value inside the air bladder 1.

[0082] The airbag 1 is flexible and deformable, and can be made of flexible materials such as rubber. When implanted into the target site, such as the ventricle or bladder, the airbag 1 deforms under the liquid pressure of the liquid substance at the target site, thereby changing the pressure of the gas environment inside the airbag 1. The shape of the airbag can be set as needed, for example, it can be cylindrical, ellipsoidal, spherical, etc. An appropriate amount of gas can be pre-injected into the airbag before the sensor leaves the factory or before use. The volume of the injected gas can be set according to requirements, and inflation is not required during surgery.

[0083] When the airbag 1 comes into direct contact with the area to be tested (e.g., with cerebrospinal fluid in the ventricles of the brain or with fluid in the bladder), the liquid in the area will exert pressure on the outer wall of the airbag 1 due to its own liquid pressure, causing the airbag 1 to deform. At this time, the air pressure inside the airbag 1 is equal to the liquid pressure of the liquid in the area to be tested. Since the first pressure sensor 2 is in communication with the gas inside the airbag 1, the pressure value measured by the first pressure sensor 2 is the air pressure value inside the airbag 1, which is also the liquid pressure value of the liquid in the area to be tested. This provides direct data for determining the pressure value of the area to be tested.

[0084] As can be seen, by combining the airbag 1 and the first pressure sensor 2 as shown in Figure 1 to form a corresponding detection sensor, there is no need for complex mechanical transmission or liquid flow structure, which greatly reduces the number of components and the space occupied. It realizes the measurement of the liquid pressure value of the liquid substance in the test site with a smaller number of components, and thus realizes the measurement of the pressure value of test sites such as the ventricle and bladder. It effectively reduces the size of the detection sensor, realizes the miniaturization of the detection sensor, and avoids direct contact between the sensor or other electronic components and human tissue to avoid potential infection risks.

[0085] In one embodiment, for example when the airbag is a cylindrical airbag tube as shown in Figure 4, the diameter of the airbag tube generally does not exceed 2.8 mm, and the length can be adjusted according to the age of the implanted subject, generally between 2 cm and 5 cm.

[0086] To improve the detection performance of the sensor, further improvements are made to the sensor with the first structure described above, as follows:

[0087] In one embodiment, referring to Figure 2, the airbag 1 has a first open end, and in this case, the biological pressure detection sensor further includes:

[0088] The first housing 3, and the first pressure sensor 2 are disposed inside the first housing 3;

[0089] The first housing 3 has an open end 20, which is connected to the first open end of the airbag 1, thereby forming a gas communication state between the interior of the first housing 3 and the airbag 1. This connection can be a sealed connection.

[0090] The first housing 3 completely encloses the first pressure sensor 2, and a certain space is left between the outer surfaces of the first housing 3 and the first pressure sensor 2 (so that the first pressure sensor 2 is in a gaseous environment connected to the airbag 1). The first housing 3 has only one opening 20, which connects to the first opening of the airbag 1, thus creating a gaseous connection between the interior of the first housing 3 and the airbag 1. Therefore, the pressure value measured by the first pressure sensor 2 is equal to the pressure value inside the airbag 1. Preferably, the effective detection surface of the first pressure sensor 2 is oriented towards the gas-containing space formed between it and the first housing, so that the effective detection surface of the first pressure sensor can fully contact the gaseous environment of the airbag 1, improving the accuracy of pressure detection. The material of the first housing can be, for example, polycarbonate.

[0091] Specifically, referring to Figure 3, the "first housing 3 has an open end 20, which is connected to the first open end of the airbag 1, thereby forming a gas communication state between the interior of the first housing 3 and the airbag 1" in Figure 2 can be specifically implemented as shown in Figure 3: a conduit 30 is provided on the surface of the first housing 3, one open end of the conduit 30 is connected to the internal space of the first housing 3, and the other open end is connected to the first open end of the airbag 1. Preferably, the first housing 3 and the conduit 30 are integrally formed, which can ensure the airtightness of the connection between the first housing 3 and the conduit. The conduit can be a hollow tubular structure, and the conduit acts as a communication medium to realize the communication between the internal space of the first housing 3 and the internal space of the airbag 1.

[0092] The first opening of the airbag 1 is sealed to the other opening of the catheter, which ensures the airtightness of the connection between the airbag 1 and the catheter and prevents air leakage at the connection between the airbag 1 and the catheter, which would disturb the air pressure inside the sensor and affect the accuracy of intracranial pressure detection.

[0093] In another embodiment, referring to FIG4, the biological pressure detection sensor may further include:

[0094] Support component 6, the first housing 3 is fixed to the support component 6 to improve the mechanical stability of the first housing 3;

[0095] The support component 6 is also equipped with a first microprocessor 7 and a first wireless power supply and communication module 8;

[0096] The first wireless power supply and communication module 8 is connected to the first microprocessor 7 and the first barometric pressure sensor 2, and can supply power to the first microprocessor 7 and the first barometric pressure sensor 2, and communicate with the external receiver 12. That is, the first wireless power supply and communication module 8 can wirelessly supply power to the internal components of the sensor and communicate with external devices.

[0097] The first microprocessor 7 is used to control the measurement frequency and switching action of the first air pressure sensor 2, acquire the air pressure value measured by the first air pressure sensor 2, and perform a first preset processing on the air pressure value measured by the first air pressure sensor 2.

[0098] In one embodiment, the first preset process can be implemented as follows: the air pressure value measured by the first air pressure sensor 2 is sent to an external receiver through the first wireless power supply and communication module 8; the external receiver determines the pressure value of the part to be measured based on the air pressure value measured by the first air pressure sensor 2.

[0099] Alternatively, the first preset processing can also be implemented as follows: determining the pressure value of the part to be measured based on the air pressure value measured by the first air pressure sensor 2; and then transmitting the pressure value of the part to be measured to an external receiver via the first wireless power supply and communication module 8. Specifically, "determining the pressure value of the part to be measured based on the air pressure value measured by the first air pressure sensor 2" can be implemented as follows: acquiring the current atmospheric pressure; and subtracting the air pressure value measured by the first air pressure sensor 2 from the atmospheric pressure, with the difference being the pressure value of the part to be measured. Acquiring the current atmospheric pressure can be achieved by the sensor obtaining the current atmospheric pressure from other external devices via the first wireless power supply and communication module. These other devices can be an external receiver or any other external device capable of measuring atmospheric pressure; no limitation is made here.

[0100] In one embodiment, the first wireless power supply and communication module may include a first NFC chip and a receiving coil. The arrangement and position of these two components within the detection sensor can be adjusted as needed. The first NFC chip is used to receive energy emitted by an external receiver via the receiving coil and convert it into a preset voltage to power the first microprocessor and the first barometric pressure sensor; and to communicate with external devices.

[0101] In one specific embodiment, referring to FIG5, the support component 6 may be further implemented as an integrated circuit board 40, and the integrated circuit board 40 is provided with a receiving coil 10; the first microprocessor 7 is connected to the first barometric pressure sensor 2 and the first NFC chip 11 respectively; the receiving coil 10 is electrically connected to the first NFC chip 11, and transfers the energy received from the external receiver to the first NFC chip 11; and the first NFC chip 11 is electrically connected to the first microprocessor 7 and the first barometric pressure sensor 2 respectively, so that the first NFC chip 11 converts the received energy into a preset voltage, thereby providing a stable power supply to the first microprocessor 7 and the first barometric pressure sensor 2.

[0102] The structure corresponding to this embodiment avoids the need to place a battery in the detection sensor, and the wireless power supply and wireless communication modules can be reused. The number of components in the entire detection sensor is small, thereby further reducing the size of the detection sensor.

[0103] In another embodiment, referring to Figure 4, since the airbag 1 is made of a flexible material, in order to ensure that the airbag 1 has sufficient mechanical strength for implantation into the test site, the detection sensor may also include a support rod 5. One end of the support rod 5 passes through the first housing 3 and is connected to the support component 6, and the other end extends into the airbag 1. The material of the support rod 5 can be a material with sufficient hardness and toughness, such as titanium wire. The support rod 5 can be, but is not limited to, having a slender rod-like structure, so as to provide sufficient support for the airbag while minimizing the space occupied by the support rod 5 inside the detection sensor.

[0104] Furthermore, when the supporting component is implemented as the aforementioned integrated circuit board, the airbag 1 may also have a second open end, and the second open end is provided with a thermally conductive plug 4. The thermally conductive plug 4 seals the second open end. The first housing 3, the airbag 1, and the thermally conductive plug 4 form a sealed gas environment space; the material of the thermally conductive plug can be metal or any material with a high thermal conductivity (this application does not limit this); at this time, the other end of the supporting rod extends through the airbag and connects to the thermally conductive plug, and a temperature sensor may also be installed inside the thermally conductive plug. When the detection sensor is implanted into the part to be measured, the thermally conductive plug 4 and the temperature sensor realize the measurement of the temperature value of the part to be measured.

[0105] Furthermore, the first microprocessor can acquire the temperature value of the part to be measured by the temperature sensor and transmit the temperature value to the first wireless power supply and communication module, thereby sending the measured temperature value of the part to be measured to an external receiver, realizing the synchronous measurement of the pressure value and temperature value of the part to be measured.

[0106] Preferably, in one embodiment, the support rod 5 can be implemented as a conductive support rod capable of conducting electricity (at this time, the material of the support rod can be a conductive material, or a support rod made of other materials with a conductive structure inside). One end of the conductive support rod is electrically connected to the circuit on the integrated circuit board, and the other end extends through the airbag and is connected to the heat-conducting plug. The temperature sensor is electrically connected to the conductive support rod, thereby enabling the temperature sensor to be connected to the first microprocessor on the integrated circuit board. This structure enables the functional devices of the detection sensor to be further highly integrated, reducing the size of the detection sensor.

[0107] In addition, the biological pressure detection sensor also includes a second housing 9, which is used to cover and protect the support component 6 and the components installed on the support component 6, so as to prevent the detection sensor from being damaged by collision during use, and also to prevent the components from directly contacting the biological tissue, thus avoiding the risk of infection.

[0108] The working principle of the biological pressure detection sensor in this application is explained below:

[0109] Referring to Figure 6, the measurement principle of the biological pressure detection sensor of this application is as follows: The upper part of the detection sensor, namely the core control unit including the support component, the first microprocessor, and the first wireless power supply and communication module, is placed horizontally in the gap between the outer surface of the skull and the scalp 90°; the air bladder and catheter components connected to the core control unit are placed into the target monitoring area. When the air bladder 1 of the detection sensor is implanted into the target monitoring area, the outer wall of the air bladder 1 comes into contact with the liquid substance in the target monitoring area, such as cerebrospinal fluid. At this time, the air pressure PINT inside the air bladder 1 and the absolute pressure P of the liquid substance in the target monitoring area are... CSF They are equal. Since the first housing 3 and the airbag 1 form a gas-connected environment, and the heat-conducting plug seals the other end of the airbag 1, thus creating a closed gas space, the absolute pressure Psens measured by the first pressure sensor 2 inside the first housing 3 is equal to the air pressure P inside the airbag 1. INT That is, the absolute pressure Psens measured by the first air pressure sensor 2 is equal to the absolute pressure P of the target monitoring area. CSF .

[0110] In one embodiment, the airbag 1 is further provided with a support structure made of three-dimensional porous material. The support structure serves the following functions: preventing the airbag membrane from nonlinearly adhering or wrinkling during pressure changes, ensuring good repeatability and linearity of the pressure deformation relationship; accelerating pressure balance and improving response speed by maintaining a permanent, tiny internal space channel; and ensuring that the inner wall membrane of the airbag does not adhere or become blocked under negative or low pressure conditions, thus avoiding the inability of the airbag to function and the occurrence of jump errors in pressure values ​​when the airbag is restarted.

[0111] Specifically, the support structure can be implemented in the following two ways:

[0112] Method 1: One-piece bushing

[0113] Referring to Figure 11, a bushing 01 is fitted to the inner wall of the airbag 1. This bushing 01 is made of a porous material (such as polyurethane foam, polyvinyl alcohol hydrogel sponge, medical silicone sponge, etc.), and is hollow, with a shape that matches the internal shape of the airbag. The thickness of the bushing 01 is thinner than that of the airbag 1. For example, the natural thickness of the airbag is 1 mm, and the thickness of the support frame is 0.8 mm. This ensures that the bushing is in a slightly compressed state inside the airbag, providing continuous support without overstretching the airbag and affecting its flexibility.

[0114] The manufacturing process of this bushing can be implemented in the following form:

[0115] Step 1: Place the bushing on the mandrel of the airbag forming mold.

[0116] Step 2: Using a two-stage injection molding or dip molding process, liquid airbag material (such as silicone or polyurethane) is wrapped around the outside of the bushing, so that the outer surface of the bushing is bonded to the inner surface of the airbag, thereby forming an airbag with the aforementioned bushing inside.

[0117] Method 2: Discrete Filler Particles

[0118] Referring to Figure 12, discrete filler particles 02 are processed from three-dimensional porous materials. These discrete filler particles are numerous and can be spherical, cylindrical, or similar in shape. The size of the discrete filler particles must be determined based on the cavity size of the airbag. They must be small enough to ensure that they form a particle cluster within the airbag, achieving a sufficient quantity; however, they must also be prevented from being too small, which could cause particle agglomeration due to van der Waals forces.

[0119] For example, the diameter of the particles can be in the range of [a*D, b*D], where D is the width (or diameter) of the air bladder cavity, a is 1 / 50, and b is 1 / 20.

[0120] Discrete filler particles 02, serving as a supporting structure, are filled into the airbag 1, and the quantity can be determined as needed.

[0121] Discrete filling particles form an omnidirectional, dead-angle-free dynamic support network through a large number of randomly distributed microparticles, fundamentally eliminating the adhesion problem of the airbag inner membrane and significantly improving the linearity and repeatability of the measurement. Furthermore, its isotropic mechanical response ensures the stability and accuracy of pressure measurement. In addition, in terms of engineering implementation, this solution is insensitive to manufacturing errors and can adapt to various complex airbag cavity shapes, greatly reducing the difficulty and cost of the production process. The natural gaps between the discrete filling particles constitute an efficient three-dimensional flow channel, ensuring rapid pressure balance and response speed.

[0122] Referring to Figure 7, this application also provides an intracellular pressure detection system, including the aforementioned intracellular pressure detection sensor and a receiver 50; the receiver 50 includes a processor and a second wireless power supply and communication module; the second wireless power supply and communication module is used to cooperate with the first wireless power supply and communication module of the intracellular pressure detection sensor to provide power to the internal components of the intracellular pressure detection sensor; and to communicate with the first wireless power supply and communication module of the intracellular pressure detection sensor to obtain the parameter values ​​measured by the intracellular pressure detection sensor; the processor is used to perform a second preset processing on the parameter values.

[0123] In one embodiment, the second wireless power supply and communication module may include a transmitting coil and a second NFC chip; correspondingly, the first wireless power supply and communication module may be implemented as a receiving coil and a first NFC chip. Of course, the receiver is equipped with a power supply module, such as a battery, to power itself. The processor controls this power supply module to provide energy to the transmitting coil. Energy is transferred between the transmitting coil and the receiving coil via electromagnetic induction, thereby enabling wireless power supply to the components within the detection sensor using the first NFC chip.

[0124] In one embodiment, the parameter values ​​obtained by the receiver from the aforementioned acquisition of pressure detection sensors within the biological body may include the air pressure value measured by the first air pressure sensor or the pressure value of the site to be measured.

[0125] When the parameter value includes the air pressure value measured by the first air pressure sensor, the above-mentioned second preset processing can be specifically implemented as follows: obtain the atmospheric pressure of the current environment; calculate the difference between the air pressure value measured by the first air pressure sensor and the atmospheric pressure of the current environment, and the difference is the pressure value of the part to be measured.

[0126] Preferably, obtaining the atmospheric pressure of the current environment can be implemented by acquiring the atmospheric pressure of the current environment from other external devices via a second wireless power supply and communication module. Alternatively, the receiver itself measures the atmospheric pressure of the current environment; in this case, the receiver may also include a second pressure sensor for measuring atmospheric pressure.

[0127] In one embodiment, to facilitate wireless power supply to the detection sensor implanted in the biological body, referring to FIG7, the receiver 50 further includes a main support portion 12 (e.g., a housing) and a transmitting coil support portion 13 (e.g., a circuit board integrating a transmitting coil); wherein, the processor and the second NFC chip are disposed in the main support portion, and the transmitting coil is disposed in the transmitting coil support portion, the main support portion and the transmitting coil support portion being separately disposed; the components on the main support portion are electrically connected and / or signal connected to the transmitting coil on the transmitting coil support portion through connecting components. The connecting components can be detachably electrically connected and / or signal connected to the components on the main support portion; or they can be detachably electrically connected and / or signal connected to the transmitting coil on the transmitting coil support portion, thereby making them more convenient to use and store. The connecting component can be a detachable component, such as a transmission line with pluggable connectors or interfaces at both ends. Correspondingly, the connector (or interface) at one end of the transmission line that connects to the components on the receiver's main body is compatible with the interface (or connector) on the main body; the connector (or interface) at the other end of the transmission line that connects to the transmitting coil on the transmitting coil carrier is compatible with the interface (or connector) on the transmitting coil carrier. Alternatively, the connecting component can be fixedly connected to the transmitting coil on the transmitting coil carrier, while the end connecting to the components on the receiver's main body has a pluggable interface (or connector). Correspondingly, the receiver's main body has a suitable pluggable connector (or interface). The length of the transmission line can be set as needed.

[0128] The following example illustrates the usage of the receiver and sensor described above: Referring to Figure 7, the upper part of the pressure sensor (i.e., the supporting component housing the first microprocessor, first wireless power supply, and communication module, etc.) is placed inside the organism (e.g., between the outer side of the skull and the subcutaneous tissue). The lower part (the airbag portion) is implanted into the organism (e.g., inserted into the brain parenchyma or ventricle through an opening in the skull. An airbag of appropriate length is selected as needed). After implantation, the scalp on the skull is sutured. The transmitting coil carrier of the receiver is fixed to the outer side of the scalp layer with a bandage or other means. The transmitting coil of the receiver and the receiving coil of the sensor are placed concentrically, with the total percutaneous distance not exceeding a specified distance to ensure efficient energy transmission between the transmitting and receiving coils.

[0129] In one embodiment, the receiver further includes at least one of a wireless communication module and a display module; wherein the wireless communication module is signal-connected to the processor to enable bidirectional communication between the receiver and an external terminal; and the display module is used to perform a display operation according to the control of the processor, thereby enabling a visual display of the pressure value of the part to be measured.

[0130] Referring to Figure 8, this is a data graph showing the test results of wireless power transfer between the transmitting coil and the receiving coil in the biological pressure detection system of the present invention. In the wireless power transfer test, the receiving coil was implanted between 3mm of pigskin and 5mm of pork tenderloin to simulate the human implantation environment, and the power transfer efficiency (PTE) between the transmitting coil and the receiving coil was tested. As can be seen from Figure 8, the maximum working distance between the transmitting coil and the receiving coil reaches 17mm, that is, within a distance range of less than or equal to 17mm, stable and efficient wireless power transfer can be achieved between the transmitting coil and the receiving coil.

[0131] Referring to Figure 9, this figure shows the test results of the in vivo pressure detection system of the present invention used in a water tank experiment. In the water tank experiment, a water tank experimental device was built to provide a controllable in vitro experimental environment for the in vivo pressure detection sensing system, thereby verifying the feasibility of using the in vivo pressure detection sensing system for liquid pressure measurement. Specifically, the in vivo pressure detection sensor of the in vivo pressure detection sensing system was placed in a water tank, and the underwater depth of the in vivo pressure detection sensor inside the water tank was adjusted. The underwater depth of the in vivo pressure detection sensor was measured using tools such as a ruler. Based on the measured underwater depth, the water pressure intensity at the location of the in vivo pressure detection sensor was calculated, and the water pressure intensity measured by the in vivo pressure detection sensing system itself was obtained. The test results, as shown in Figure 9, show that within the range of 0–18 mmHg, the difference between the measured water pressure intensity and the calculated water pressure intensity is less than ±0.1 mmHg.

[0132] Referring to Figure 10, this is a data graph showing the full-range nonlinear error test results of the biological pressure detection sensing system of the present invention. As can be seen from Figure 10, the test range is -20 to 150 mmHg, and the measurement nonlinear error is less than ±0.3 mmHg throughout the entire test range.

[0133] The in vivo pressure detection system provided in this invention, through collaboration with miniaturized, highly integrated detection sensors, achieves safe, accurate, and convenient monitoring of intracellular pressure. This system utilizes wireless power transmission technology to stably power the in vivo sensors and receives their measured pressure and temperature data. It not only maintains and leverages the core advantages of the sensors—small size, no battery, and avoidance of tissue damage—but also transforms the raw sensor signals into directly usable clinical information through intelligent processing and display functions at the receiver end. Ultimately, this system achieves a complete closed loop from in vivo sensing to external display, significantly improving patient comfort and the safety and convenience of clinical procedures while ensuring high accuracy and stability.

[0134] In summary, the biological pressure detection sensor and detection system provided in this embodiment of the invention can obtain the liquid pressure value of the test site by combining an airbag with a first pressure sensor, providing data for subsequent determination of the pressure value of the test site. The combination of an airbag structure and a pressure sensor effectively reduces the size of the detection sensor. At the same time, the airbag structure can avoid the risk of damage caused by direct contact between the pressure sensor or other electronic components and biological tissues. The detection sensor may also include a first wireless power supply and communication module, which realizes wireless power supply to the internal components of the detection sensor and communication with external devices. This makes the structure of the detection sensor highly integrated, eliminates the need for a battery, further reduces the size of the detection sensor, improves the user experience, ensures the processing and communication performance of the detection sensor, improves the ease of operation of the detection sensor, and can provide real-time and reliable data for judging diseases and injuries.

[0135] Although preferred embodiments of the invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of the invention.

[0136] Obviously, those skilled in the art can make various modifications and variations to the embodiments of the present invention without departing from the spirit and scope of the embodiments of the present invention. Thus, if these modifications and variations to the embodiments of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention also intends to include these modifications and variations.

Claims

1. A pressure detection sensor within a biological organism, characterized in that, include: An airbag is used to implant into the site of the test. The first pressure sensor is located in an environment connected to the gas inside the airbag and is used to measure the pressure value inside the airbag.

2. The bio-based pressure detection sensor as described in claim 1, characterized in that, The airbag has a first open end; The biological pressure detection sensor also includes: A first housing, wherein the first pressure sensor is disposed inside the first housing; The first housing has an open end, which is connected to the first open end of the airbag, thereby creating a gas communication state between the interior of the first housing and the airbag.

3. The biological pressure detection sensor as described in claim 2, characterized in that: The first housing has an open end, which is connected to the first open end of the airbag, thereby creating a gas communication state between the interior of the first housing and the airbag, specifically: A conduit is provided on the surface of the first housing, with one open end of the conduit communicating with the internal space of the first housing and the other open end communicating with the first open end of the airbag.

4. The biological pressure detection sensor as described in claim 3, characterized in that: The first housing and the conduit are integrally formed.

5. The biological pressure detection sensor according to any one of claims 2-4, characterized in that, Also includes: A support component, wherein the first housing is fixed to the support component; The supporting component is also provided with a first microprocessor and a first wireless power supply and communication module; The first wireless power supply and communication module is used to supply power to the first microprocessor and the first barometric pressure sensor, and to communicate with an external receiver. The first microprocessor is used to control the working state of the first air pressure sensor, acquire the air pressure value measured by the first air pressure sensor, and perform a first preset processing on the air pressure value measured by the first air pressure sensor.

6. The biological pressure detection sensor as described in claim 5, characterized in that: The first preset process includes: The first wireless power supply and communication module transmits the air pressure value measured by the first air pressure sensor to an external receiver. or, The pressure value of the part to be tested is determined based on the air pressure value measured by the first air pressure sensor, and the pressure value of the part to be tested is sent to an external receiver through the first wireless power supply and communication module.

7. The biological pressure detection sensor as described in claim 5, characterized in that: The first wireless power supply and communication module includes: a first NFC chip and a receiving coil; The first NFC chip is used to receive energy emitted by an external receiver through the receiving coil and convert it into a preset voltage to power the first microprocessor and the first barometric pressure sensor; and to enable communication with external devices.

8. The biological pressure detection sensor as described in claim 7, characterized in that: The supporting component includes an integrated circuit board, on which the receiving coil is disposed.

9. The biological pressure detection sensor as described in claim 5, characterized in that, Also includes: A support rod, one end of which passes through the first housing and is connected to the support component, and the other end extends into the airbag.

10. The biological pressure detection sensor as described in claim 9, characterized in that: When the supporting component is an integrated circuit board: The airbag also has a second opening end, and the second opening end is provided with a heat-conducting plug. The other end of the support rod extends through the airbag and connects to the heat-conducting plug; A temperature sensor is installed inside the thermally conductive plug.

11. The biological pressure detection sensor as described in claim 10, characterized in that: The first microprocessor is also used to acquire the temperature value of the part to be measured monitored by the temperature sensor, and send the temperature value of the part to be measured to an external receiver through the first wireless power supply and communication module.

12. The biological pressure detection sensor according to any one of claims 5-11, characterized in that, Also includes: The second housing is used to cover and protect the support component and the components disposed on the support component.

13. The biological pressure detection sensor according to any one of claims 1-4, characterized in that, The airbag is also equipped with a support structure made of three-dimensional porous material; The support structure is implemented as follows: a bushing is fitted to the inner wall of the airbag; The bushing is made of a three-dimensional porous material, which is hollow and its shape is adapted to the internal shape of the airbag. The thickness of the bushing is thinner than that of the airbag.

14. A biological pressure detection system, comprising a biological pressure detection sensor as described in any one of claims 5-13, and a receiver, characterized in that: The receiver includes a processor, a second wireless power supply and communication module; The second wireless power supply and communication module is used to cooperate with the first wireless power supply and communication module of the biological pressure detection sensor to provide power to the internal components of the biological pressure detection sensor; and to communicate with the first wireless power supply and communication module of the biological pressure detection sensor to obtain the parameter values ​​measured by the biological pressure detection sensor. The processor is used to perform a second preset processing on the parameter value.

15. The biological pressure detection system as described in claim 14, characterized in that: The parameter values ​​include the air pressure value measured by the first air pressure sensor, or the pressure value of the part to be measured; The second preset processing includes: When the parameter value includes the air pressure value measured by the first air pressure sensor, the pressure value of the part to be measured is determined based on the air pressure value measured by the first air pressure sensor.

16. The biological pressure detection system as described in claim 14, characterized in that: The second wireless power supply and communication module includes a transmitting coil and a second NFC chip.

17. The biological pressure detection system as described in claim 16, characterized in that: The receiver also includes a main body support and a transmitting coil support; The processor and the second NFC chip are disposed in the main body carrier; The transmitting coil is disposed on the transmitting coil support portion; The main support portion and the transmitting coil support portion are separately configured; The components on the main body support are electrically and / or signal connected to the transmitting coil on the transmitting coil support through connecting components.

18. The biological pressure detection system as described in claim 17, characterized in that: The connecting component is detachably electrically and / or signal-connected to the components on the main body support; and / or The connecting component is detachably electrically connected and / or signal connected to the transmitting coil on the transmitting coil carrier.

19. The biological pressure detection system as described in claim 15, characterized in that: The receiver also includes a second pressure sensor for measuring atmospheric pressure; When the parameter value includes the air pressure value measured by the first air pressure sensor, determining the pressure value of the part to be measured based on the air pressure value measured by the first air pressure sensor includes: When the parameter value includes the air pressure value measured by the first air pressure sensor, the pressure value of the part to be measured is determined based on the atmospheric pressure and the air pressure value measured by the first air pressure sensor.

20. The biological pressure detection system according to any one of claims 14-19, characterized in that: The receiver further includes at least one of a wireless communication module and a display module; wherein... The wireless communication module is connected to the processor and is used to enable bidirectional communication between the receiver and an external terminal. The display module is used to perform display operations according to the control of the processor.

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