Controlled release of cell nuclei by histotripsy

The histotripsy system with real-time imaging and robotic control provides precise tissue ablation by adjusting acoustic cavitation, addressing the limitations of invasive and imprecise non-invasive methods, ensuring safe and effective tissue treatment.

WO2026101648A1 Publication Date: 2026-05-15THE RGT UNIV OF MICHIGAN
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Patent Information

Application Number
PCT/US2025/049936
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-11-08
Filing Date
2025-10-07
Publication Date
2026-05-15

AI Technical Summary

Technical Problem

Existing medical procedures for treating tissue conditions often require invasive methods that cause trauma, bleeding, scarring, and other complications, while non-invasive and minimally invasive techniques lack precision and safety, particularly in the use of histotripsy for tissue ablation.

Method used

A histotripsy system with real-time ultrasound imaging and robotic positioning to deliver controlled acoustic cavitation pulses, adjusting delivery based on ultrasound backscatter parameters and cavitation emission signals to ensure precise tissue destruction without collateral damage.

Benefits of technology

Enables fast, efficacious tissue destruction with minimal damage to non-target tissues, allowing for non-invasive and minimally invasive treatments with improved precision and safety.

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Abstract

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Methods of biological tissue modification are also provided. The systems and methods disclosed here are uniquely different in that they aim to target, plan and treat target tissue, and selectively destroy and modify cellular architecture, but with specific intent and treatment parameters specialized for retaining specific target physical biological structures within the cell itself.
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