Cartilage endplate-targeting composite hydrogel, preparation method therefor, and use thereof

By preparing a composite hydrogel that targets the cartilaginous endplate, the problems of nutrient supply obstruction and microenvironment deterioration in existing IVDD treatments have been solved, achieving targeted treatment of CEPCs, reducing inflammation and improving cell function, and promoting intervertebral disc regeneration.

WO2026113165A1PCT designated stage Publication Date: 2026-06-04WANGJING HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
WANGJING HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
Filing Date
2025-03-05
Publication Date
2026-06-04

AI Technical Summary

Technical Problem

Existing treatments for intervertebral disc disease (IVDD) cannot effectively target the cartilaginous endplate, leading to obstructed nutrient supply, deterioration of the microenvironment, and failure to effectively alleviate inflammation of CEPCs and aging of NPCs, thereby exacerbating disease progression.

Method used

A composite hydrogel targeting the cartilage endplate was developed, comprising cartilage-targeting peptide-modified drug-loaded exosomes, calcium carbonate, and chitosan, prepared by sonication and incubation steps. It can target CEPCs, release salvianolic acid A, limit iron ion influx, neutralize the acidic environment, inhibit specific signaling pathways, reduce inflammation, and improve cell function.

Benefits of technology

This composite hydrogel can effectively target CEPCs, reduce inflammation, improve cell function, inhibit NPC aging, and promote intervertebral disc regeneration, providing a new approach for multi-target treatment of IVDD.

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Abstract

Disclosed are a cartilage endplate-targeting composite hydrogel, a preparation method therefor, and use thereof. The cartilage endplate-targeting composite hydrogel comprises drug-loaded exosomes modified with a cartilage-targeting peptide, calcium carbonate, chitosan, and water; the drug-loaded exosomes modified with the cartilage-targeting peptide comprise exosomes, a cartilage-targeting peptide, and salvianolic acid A. The cartilage endplate-targeting composite hydrogel is prepared by encapsulating salvianolic acid A in human mesenchymal stem cell-derived exosomes, modifying the human mesenchymal stem cell-derived exosomes with a cartilage-targeting peptide to obtain drug-loaded exosomes modified with the cartilage-targeting peptide, and then mixing the drug-loaded exosomes modified with the cartilage-targeting peptide with calcium carbonate, chitosan, and water.
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