Embolic coil delivery systems and components

Abstract

Described are systems for delivering embolic coil devices, and components useful in such systems. The systems include a flexible elongate delivery shaft having a distal region and an embolic coil device detachably connected to the distal region of the elongate delivery shaft. In some forms, the systems have a coil detachment interface at a distal region of a flexible elongate delivery shaft. The coil detachment interface includes a distal tubular segment and a bridge component proximal of the distal tubular segment.

Description

[0001] 003620-002993 #3563408

[0002] 1

[0003] EMBOLIC COIL DELIVERY SYSTEMS AND COMPONENTS

[0004] BACKGROUND

[0005] The present disclosure relates generally to systems for implanting embolic coil devices for establishing an embolus or vascular occlusion in a patient vessel, and to devices and components useful in such systems.

[0006] Embolic coil devices are used to treat a variety of medical conditions, including for example to treat intravascular aneurysms. An embolic coil typically takes the form of a soft, helically wound coil formed by winding wire (e.g. a platinum or platinum alloy wire) about a primary mandrel. In some known forms, the thus-formed coil is then wrapped around a larger, secondary mandrel, and heat treated to impart memory for a secondary shape. The secondary shape can also be imparted by cold forming. Upon delivery from a tubular device such as a catheter to a treatment site, the coil will transition to or toward its more convoluted secondary shape.

[0007] Various arrangements are known for detaching the coil from the delivery shaft, including notably electrolytic and mechanical detachment arrangements. Many known mechanical detachment arrangements have a delivery shaft defining a lumen and a pull wire (also termed a "release" wire) that interfaces with a feature of the coil device and that can be moved proximally in the shaft lumen to cause detachment of the embolic coil device.

[0008] There remain needs for embolic coil delivery systems that incorporate detachment features or mechanical detachment arrangements that are conducive to manufacture and that are easy and reliable in use. Aspect of the present disclosure are address to these needs. 003620-002993 #3563408

[0009] 2

[0010] SUMMARY

[0011] In some aspects, provided are systems for delivering an embolic coil device. The systems include a flexible elongate delivery shaft having a distal region. An embolic coil device is detachably connected to the distal region of the elongate delivery shaft with coil windings of the embolic coil device in a resiliently longitudinally compressed condition. Upon detachment of the embolic coil device from the elongate delivery shaft the coil windings resiliently move to a longitudinally extended condition, where the coil windings in the longitudinally extended condition are more open than they are in the resiliently longitudinally compressed condition.

[0012] In accordance with some forms, the present disclosure provides a coil detachment interface member for a system for delivering an embolic coil device. Accordingly, in one embodiment, the disclosure provides for a device comprising an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis, a bridge component having a rounded external profile and mounted to the outer wall, the bridge component extending transversely to the longitudinal axis of the interface body, a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device, a second path positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire, a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of and proximate to a proximal surface of the bridge component, and a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge of the interface body. In certain embodiments the outer wall may be tubular. In some forms, the device also comprises a second sidewall opening in the outer wall, the second sidewall opening coextending at least partly with the first sidewall opening alongthe longitudinal axis of the interface body. A portion of the second sidewall opening may occur proximal of and proximate to the proximal surface of the bridge component. In some forms, the second sidewall opening and the clearance slot are radially aligned along the length of the interface body. In certain embodiments, the interface body comprises a first mounting void and a second mounting void, and wherein said bridge component is mounted in 003620-002993 #3563408

[0013] 3 said first and second mounting voids. Such mounting voids may comprise an aperture and / or a slot in the outer wall. In accordance with some forms, a support strut extends between a proximal wall of the clearance slot and a distal wall ofthe second sidewall opening. The interface body also may also include a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface.

[0014] In another embodiment the present disclosure provides, A system for delivering an embolic coil device, comprising: a flexible elongate delivery shaft defining a lumen and having a distal region, a coil detachment interface member at the distal region of the flexible elongate delivery shaft, a pull wire, and an embolic coil device detachably connected to the distal region ofthe elongate delivery shaft. The coil detachment interface member may include: an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis, a bridge component having a rounded external profile and mounted to the outer wall, the bridge component extending transversely to the longitudinal axis ofthe interface body, a first path positioned to a first side of the bridge component, a second path positioned to a second side of the bridge component, a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of a proximate to a proximal surface of the bridge component, and a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge if the interface body. In some forms the embolic coil device has a loop member received through the first path. In certain embodiments, the pull wire extends through the lumen of the elongate delivery shaft and is received through the loop member and the second path to attach the embolic coil device to the elongate delivery shaft, such that proximal retraction of the pull wire causes detachment of the embolic coil device from the elongate delivery shaft. In certain embodiments the outer wall may be tubular. In some forms, the device also comprises a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening along the longitudinal axis of the interface body. A portion of the second sidewall opening may occur proximal of and proximate to the proximal surface of the bridge component. In some forms, the second sidewall opening and the clearance slot are radially aligned along the length of the 003620-002993 #3563408

[0015] 4 interface body. In certain embodiments, the interface body comprises a first mounting void and a second mounting void, and wherein said bridge component is mounted in said first and second mounting voids. Such mounting voids may comprise an aperture and / or a slot in the outer wall. In accordance with some forms, a support strut extends between a proximal wall of the clearance slot and a distal wall ofthe second sidewall opening. The interface body also may also include a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface. In some forms, a proximal end ofthe loop member is held at a position proximal ofthe bridge component, for example against a distal edge of the first sidewall opening, until proximal retraction of the pull wire.

[0016] In another embodiment the present disclosure provides, a coil detachment interface member for a system for delivering an embolic coil device, comprising: an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis, a bridge component mounted to the outer wall, the bridge component extending transverse to the longitudinal axis ofthe interface body, a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device, and a second path positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire, wherein at least one of the first path and the second path occurs between a surface ofthe bridge component and an inner surface ofthe outer wall, a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of and proximate to a proximal surface of the bridge component, and a mount arrangement in which the bridge component is mounted in opposed first and second voids in the outer wall. In certain embodiments the outer wall may be tubular. Certain variants include a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge of the interface body. In some forms, the device also comprises a second sidewall opening in the outer wall, the second sidewall opening coextending at least partly with the first sidewall opening alongthe longitudinal axis ofthe interface body. A portion of the second sidewall opening may occur proximal of and proximate to the proximal surface of the bridge component. In some forms, the second 003620-002993 #3563408

[0017] 5 sidewall opening and the clearance slot are radially aligned along the length of the interface body. In certain embodiments, mounting voids may comprise an aperture and / or a slot in the outer wall. In accordance with some forms, a support strut extends between a proximal wall of the clearance slot and a distal wall ofthe second sidewall opening. The interface body also may also include a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface.

[0018] In other embodiments the present disclosure provides, a system for delivering an embolic coil device, comprising: a flexible elongate delivery shaft defining a lumen and having a distal region, a coil detachment interface member at the distal region of the flexible elongate delivery shaft, a coil detachment interface member, a pull wire, and an embolic coil device. The coil detachment interface member may include: an interface body having an outer wall, and a longitudinal axis, a bridge component mounted to the outer wall, the bridge component extending transversely to the longitudinal axis of the interface body, a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device, and a second path positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire, wherein at least one of the first path and the second path occurs between a surface of the bridge component and an inner surface of the outer wall, a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of a proximate to a proximal surface of the bridge component, and a mount arrangement in which the bridge component is mounted in opposed first and second voids in the outer wall. In some forms, the embolic coil device is detachably connected to the distal region ofthe elongate delivery shaft, for example by having a loop member received through the first path. In some forms, the pull wire extends through the lumen of the elongate delivery shaft and is received through the loop member and the second path to attach the embolic coil device to the elongate delivery shaft. In certain embodiment, proximal retraction of the pull wire causes detachment of the embolic coil device from the elongate delivery shaft. In certain embodiments the outer wall may be tubular. In some forms, the interface body includes a clearance slot in the outer wall independent ofthe first sidewall opening and 003620-002993 #3563408

[0019] 6 extending proximally from a distalmost leading edge of the interface body. In some forms, the device also comprises a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening along the longitudinal axis of the interface body. A portion of the second sidewall opening may occur proximal of and proximate to the proximal surface of the bridge component. In some forms, the second sidewall opening and the clearance slot are radially aligned along the length of the interface body. In certain embodiments, the mounting voids may comprise an aperture and / or a slot in the outer wall. In accordance with some forms, a support strut extends between a proximal wall of the clearance slot and a distal wall of the second sidewall opening. The interface body also may also include a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface. In some forms, a proximal end of the loop member is held at a position proximal of the bridge component, for example against a distal edge of the first sidewall opening, until proximal retraction of the pull wire.

[0020] Still further embodiments, as well as features and advantages of embodiments described herein, will be apparent to persons skilled in the relevant field from the descriptions herein.

[0021] 003620-002993 #3563408

[0022] 7

[0023] BRIEF DESCRIPTION OF THE DRAWINGS

[0024] FIG. 1 provides an illustration of one embodiment of an embolic coil delivery system herein received within a catheter with portions of the catheter cut away to display system components therein.

[0025] FIG. 2 provides an enlarged view of section 2S of FIG. 1.

[0026] FIG. 3 provides a cross-sectional view of components in the region of a delivery shaft / coil device interface of the system of FIG. 1.

[0027] FIG. 4 provides a side view of a coil detachment interface member forming the distal-most segment of a delivery shaft of the system of FIG. 1.

[0028] FIG. 5 provides a distal end view of the coil detachment interface member of FIG. 4.

[0029] FIG. 6 provides a perspective view of the coil detachment interface member of FIG. 4.

[0030] FIG. 7 side view of one embodiment of a coil detachment interface member

[0031] FIG. 8 provides a distal end view of the coil detachment interface member of FIG. 7.

[0032] FIG. 9 provides a perspective view of the coil detachment interface member of FIG.

[0033] FIG. 10 provides an illustration of the embolic coil device and the distal end of the delivery shaft of the system of FIG. 1 prior to associating the delivery shaft and the embolic coil device with a detachable connection.

[0034] 003620-002993 #3563408

[0035] 8

[0036] DETAILED DESCRIPTION

[0037] Reference will now be made to certain embodiments, some of which are illustrated in the drawings, and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the disclosure is thereby intended. Any alterations and further modifications in the described embodiments and any further applications of the principles as described herein are contemplated as would normally occurto one skilled in the art to which this disclosure relates.

[0038] As disclosed above, aspects of the present disclosure relate to systems for delivering an embolic device to a patient, and related devices, components and methods. The systems can include an elongate delivery shaft and an embolic device, for example an embolic coil device, detachably connected to a distal region of the delivery shaft, wherein the medical device can be detached from the delivery shaft by proximal movement of a pull wire.

[0039] As used herein, the term "proximal" means close to the operator and the term "distal" means away from the operator.

[0040] Spatially relative terms such as "lower", "upper", "under", "over", "above" and the like may be used to describe and element's and / or feature's relationship to another element(s) orfeature(s), for example as depicted in the Figures. It will be understood that the spatially relative terms are intended to encompass different operations of the system, device or component in use in addition to the orientation described or depicted in the Figures. For example, if a device or component as depicted in the Figures is inverted, an element that is shown and described as "upper" would then be oriented as "lower".

[0041] Turning now to the Figures, FIG. 1 illustrates a system 10 for delivering an embolic device 12 to a vascular space such as an aneurysm, received within the lumen of a catheter 300. The embolic device 12 may be formed as an embolic coil device 14 having 003620-002993 #3563408

[0042] 9 a plurality of coil windings 16 extending from a proximal end 16A to a distal end 16B. Typically, the coil windings 16 are made from wire, with the wire usually made of a metal such as a platinum, a platinum alloy, or a superelastic metal alloy (e.g. a superelastic nickel / titanium alloy such as nitinol). The diameter of the wire forming the coil windings 16 may be in the range of about 0.005 mm to about 0.15 mm. The coil formed by windings 16 may have an outer primary diameter of between about 0.075 and about 1 mm and in some forms will have an outer primary diameter of between about 0.2 mm and about 0.5 mm, especially those coil devices 14 intended for use in neurovascular applications.

[0043] The axial length of the embolic coil device 14 will usually fall in the range of around 0.5 to around 100 cm, more usually around 2 to 60 cm. It will be understood, however, that other axial lengths may be employed depending on the application. As well, it will be understood that the embolic coil device 14 may have a thrombogenic material such as fibers (not shown) connected to the coil windings 16 to enhance its thrombogenicity, and that other embolic coil devices describe herein may also similarly include such a thrombogenic material.

[0044] With continued reference to FIG. 1 together with FIG. 2, the coil device 14 includes a proximal retention member in the form of a loop 18. The retention member in the illustrated embodiment is formed as loop 18 by a length of filament 20 that is attached to the coil device 14. The filament 20 can be formed from a suitable polymeric or metal material, for example, and may in some variants have a diameter of about 0.01 to about 0.1 mm. A suture material, especially a durable (non-bioabsorbable) suture material, may be suitably used as filament 20. The loop 18 provides two filament segments 20A and 20B that extend into and are attached to the coil windings 16, as discussed further below. While the specifically illustrated retention member is a loop 18, other retention members are known and can be used, including as examples balls, hooks, clasps, or other similar elements that can facilitate a detachable connection of the embolic coil device to the delivery shaft. 003620-002993 #3563408

[0045] 10

[0046] The delivery system 10 also includes a flexible elongate delivery shaft 22 having a distal end 24, a proximal end 26, and a lumen 28 therebetween. The delivery shaft 22 may be formed from any suitable material, including as examples polymeric materials, metal materials, or combinations thereof. Metal hypotube materials such as stainless steel hypotube or nitinol hypotube material may be used. As illustrative polymer materials, flexible and lubricious materials such as polyimide, polytetrafluoroethylene (PTFE), polyetheretherketone (PEEK), fluorinated ethylene propylene (FEP), or the like, may be used. As well, combinations of different metal hypotube materials, such as a combination including a first stainless steel hypotube segment attached (e.g. welded) to a second, different stainless steel hypotube segment can typically be used. For example, the second stainless steel hypotube segment may be positioned distal to, and may be more flexible and / or shorter than, the first hypotube segment. This can provide an overall delivery shaft 22 that is more flexible in its distal region than in its proximal region. Combinations of other materials that provide a more flexible distal region and a less flexible proximal region can also be used in some forms. In some forms, the flexible elongate delivery shaft may be formed from a woven metallic material, for example woven steel.

[0047] Metal hypotube materials, and thus the segments of the delivery shaft 22 made from them, can in some aspect have internal diameters in the range of about 0.5 to about 0.9 mm and / or external diameters in the range of about 0.6 to about 1 mm. In some preferred small diameter forms, such hypotube materials will have internal diameters in the range of about 0.1 to about 0.4 mm and / or external diameters in the range of about 0.2 to about 0.5 mm. The wall thickness of the hypotube materials, between the internal and the external diameter, can range from about 0.05 to about 0.25 mm.

[0048] Woven steel tube materials, and thus the segments of the delivery shaft 22 made from them, can in some aspect have internal diameters in the range of about 0.0762 to about 2.2098 mm and / or external diameters in the range of about 0.127 to about 4.064 mm. In some preferred small diameter forms, such woven steel tube materials will have 003620-002993 #3563408

[0049] 11 internal diameters in the range of about 0.1 to about 0.4 mm and / or external diameters in the range of about 0.2 to about 0.5 mm.

[0050] The delivery shaft 22 will generally have a length between the distal end 24 and the proximal end 26 that permits the shaft to be advanced intravascularly to the target site for delivery of the coil device 14 while leaving the proximal end 26 positioned outside of the patient's body. For example, the delivery shaft 22 can have a length in the range of about 1 to about 2 meters.

[0051] With reference particularly to FIGs. 1, 2 and 3, the system 10 also includes an elongate pull wire 30 disposed within the lumen 28 of the delivery shaft 22. The elongate pull wire 30 has a distal end 32 (see FIG. 3) and a proximal end 34 (see FIG. 1). The elongate pull wire 30 is typically formed from a flexible material that provides sufficient column strength to avoid breakage or kinking during use of the system 10. For example, the elongate pull wire 30 may be formed from one or more polymeric or metal materials, or combinations thereof. The pull wire 30 may be formed from a metal such as nitinol, titanium, titanium alloy, platinum, stainless steel or the like. The pull wire 30 has a diameter that is less than the diameter of the lumen 28 of the elongate delivery shaft 22. In one exemplary embodiment, the pull wire 30 is formed from nitinol, optionally coated with a lubricious polymer such as polytetrafluoroethylene (PTFE) and has an outer diameter of about 0.1 mm.

[0052] The system 10 may also include an arrangement for protecting against unintended proximal retraction of the pull wire 30 that may cause unintended release of the coil device 14. As illustrated in FIG. 1, at a first location 36, the delivery shaft 22 is attached to the pull wire 30. This attachment can, for example, be provided by an amount of adhesive 38, although other attachments such as welds or frictional engagements provided by one or more crimps of the shaft 22 against the outer surface of the pull wire 30 may be used. This attachment fixes the relative positions of the shaft 22 and pull wire 30. At a second location 40 distal of the first location 36, the delivery shaft 22 has a section at which the shaft 22 is configured to selectively break and separate in response 003620-002993 #3563408

[0053] 12 to bending forces applied across the first location 36 (as compared to the sections of shaft 22 that flank location 36 on either side). In some forms, delivery shaft 22 may include one or more perforations 42 or other weakened areas to facilitate selective breakage of the shaft. After this, the separated proximal piece of shaft 22, which is attached the pull wire 30 at location 36, can be moved (e.g. pulled) proximally so as to retract pull wire 30 proximally within lumen 28 in a sliding movement and thereby cause detachment of the embolic coil device 14, as will be discussed in more detail below. In this manner, the system 10 can be used to advance the embolic coil device 14 to a desired target location in the vasculature ofthe patient, after which the shaft 22 can be broken and separated at location 40 and the separated proximal piece of shaft 22 can be pulled proximally to cause detachment of the coil device 14.

[0054] With reference now to FIGs. 1 to 10 together, embodiments will be described in which the distal region of the shaft 22 that provides an interface for detachable connection and release of the embolic coil device 14 is beneficially configured. In the illustrated embodiment, a coil detachment interface member 44 provides the distalmost segment ofthe shaft 22. Coil detachment interface member 44 extends from a distal end 46 that provides the distal end 24 of shaft 22, to a proximal end 48. Coil detachment interface member 44 generally has three segments, a distal segment 50, an intermediate or bridge segment 52, and a proximal segment 54. In the illustrated embodiment, the distal segment 50 is provided as a tubular segment that defines a lumen 55 and a distally-facing partial circumferential end surface 56. In some forms, end surface 56 may provide a full circumferential end surface. End surface 56 advantageously provides an annular surface (partial or full circumferential) with an outer circular circumference and an inner circular circumference, for interfacing with (e.g. abutting) the proximal end 16A of the coil windings 16 of the coil device 14. In accordance with some forms, a substantial distally facing end surface, for example one that provides a coplanar end surface for at least 270 degrees or at least 320 degrees around a circumference (such surface extent being continuous in some forms and discontinuous in other forms), will be advantageous and is desirably provided. The end surface 56 may have an outer circumference at least as great as, and potentially greater 003620-002993 #3563408

[0055] 13 than, the primary outer diameter of the coil formed by coil windings 16 at the proximal end 16A.

[0056] In certain embodiments, intermediate segment 52 of coil detachment interface member 44 provides a transverse bridge component, preferably in the form of a bridge component 90, that extends transverse to, and preferably perpendicular to, the longitudinal axis of the delivery shaft 22. Bridge component 90 preferably has a rounded external profile. Such rounded profile prevents snagging of the loop and / or pull wire in association with the bridge component. Bridge component 90 can, as depicted, be cylindrically-shaped in longitudinal cross-section (see e.g. FIG. 3). In other embodiments, the bridge component 90 can have another shape in longitudinal crosssection, for example egg shaped, ovoid, or another polygonal or rounded shape in longitudinal cross-section. Bridge component 90 defines an upper surface 60, a lower surface 62, a distally-facing surface 64, and a proximally-facing surface 66. In accordance with some forms, bridge component 90 is recessed within the lumen of interface member 44, such that bridge component 90 is positioned having a distal-most surface (e.g. distally-facing surface 64) positioned proximally from distal end surface 56.

[0057] Intermediate segment 52 also defines at least one sidewall opening, for example first sidewall opening 68 and / or an opposite side opening such as second sidewall opening 70 which may, for example, provide access to facilitate assembly steps during the manufacture of system 10 and in particular the coordination and assembly of the loop 18 of the coil device 14 secured around the pull wire 30 at a location proximal of the bridge component 90 or other transverse bridge component. To facilitate these purposes, the at least one side opening, e.g. opening 68 and / or opening 70, can have a substantial maximum width in a direction perpendicularto the longitudinal axis of coil detachment interface member 44, for example with such width being at least 40%, or at least 50%, or at least 60%, of a value equal to the corresponding width of the coil detachment interface member that longitudinally coextends with the opening(s). In addition or alternatively, the at least one side opening (e.g. opening 68 and / or 70) can have a substantial maximum length in the direction of the longitudinal axis of the coil 003620-002993 #3563408

[0058] 14 detachment interface member 44, for example with such length being at least equal to, and in some forms greater than (for example at least 150% of or at least 200% of) a value equal to the maximum width of the opening in a direction perpendicularto the longitudinal axis of the coil detachment interface member 44. As well, the at least one side opening (e.g. opening 68 and / or opening 70) can be positioned to have a portion of the opening(s) occurring proximal and proximate to the proximal surface of the bridge component 90 or other transverse bridge component, for example wherein such portion of the opening is proximal of the proximal surface of the bridge component 90 or other transverse bridge component by a distance no greater than 200%, or in some forms no greater than 100%, of a value equal to the width of the coil detachment interface member 44 that longitudinally coextends with the opening(s). First sidewall opening 68 may occur longitudinally overlapping proximally-facing surface 66 of bridge component 90, or at a position proximal to proximally-facing surface 66 of bridge component 90. Opposite longitudinal wall struts 72 and 74 of intermediate segment 52 span between openings 68 and 70 and extend from tubular proximal portion 54 to bridge containing portion near the distal end of interface member 44.

[0059] Coil detachment interface members of the present disclosure may also include a clearance slot positioned at the distal end of the coil detachment interface member. In some embodiments, the clearance slot comprises a slot cutout from the tubular structure of the coil detachment interface member, such that the distally-facing end surface is partially circumferential, preferably extending circumferentially at least about 200 degrees, more preferably extending circumferentially at least about 250 degrees. In certain embodiments, the clearance slot and the second sidewall opening may be radially aligned along the length of the interface body. In such forms, a support strut may be present extending between the clearance slot and the second sidewall opening. The support strut may comprise part of a tubular structure from which the interface body is formed. Openings in the coil detachment interface member sidewall, such as a clearance slot, a first sidewall opening, and / or a second sidewall opening, may provide access to the interior of the coil detachment interface memberto facilitate loading of 003620-002993 #3563408

[0060] 15 the device (e.g., attachment of an embolic coil device). For example, such openings may be useful when inserting a tool or other object when loading the device.

[0061] With reference to the illustrated embodiments, clearance slot 100 extends between opposing clearance slot sidewalls 106, 108 from open end 102 to clearance slot end wall 104. Open end 102 is positioned at the distal end 46 of coil detachment interface member 44 such that distal end 46 comprises a partially circumferential surface. Clearance slot 100 extends proximally at least to a position proximal to the proximal- most surface of bridge component 90. Clearance slot 100 has a width 110 between clearance slot sidewalls 106, 108. Bridge component 90 has a length extending transverse to the longitudinal axis of the delivery shaft between opposing portions of inner surface 84. In some forms, the clearance slot width 110 is less than the length of bridge component 90. In certain embodiments, clearance slot 100 and second side wall opening 70 are radially aligned along a length of coil detachment interface member 44, such that second side wall opening 70 is positioned proximal to clearance slot 100. In certain embodiments, support strut 120 extends transversely (e.g. perpendicularly) to the longitudinal axis of the interface member 44 and has a width defined between clearance slot end wall 104 and the second side wall opening distal end 140. Second side wall opening 70 has a width between second side wall longitudinal walls 142, 144. In accordance with some forms, the clearance slot width 110 is less than the second side wall opening width. In other forms, the clearance slot width 100 is equivalent to the second side wall opening width.

[0062] The proximal segment 54 of coil detachment interface member 44 is generally tubular in shape. In some embodiments, the proximal segment 54 may define one or more side wall openings which may provide a means to mount coil detachment interface member 44 during stages of its manufacture or its handling in assembly steps (e.g. in conjunction with positioning other components such as a loop member attached to a coil as described herein), and / or visual sight line(s) or other access to the interior of coil detachment interface member 44. Proximal segment 54 provides the proximal end 48 of coil detachment interface member 44 and defines a lumen 79 and a proximally- 003620-002993 #3563408

[0063] 16 facing full circumferential end surface 80. Full circumferential end surface 80 advantageously provides a complete 360-degree surface for an end-to-end attachment of the coil detachment interface member 44 to the adjacent segment of delivery shaft 22, for example provided by an adjacent length of metal (e.g. stainless steel) hypotube or other tube material. This attachment in some forms can be a welded attachment.

[0064] The coil detachment interface member 44 defines an inner lumen 82 defined by an inner tube surface 84 of the coil detachment interface member 44 Bridge component 90 extends transverse to the longitudinal axis of the interface member 44 within lumen 82 from a first portion of inner tube surface 84 to a second portion of inner tube surface 84. In this way, a first path 92 extends between lower surface 62 of bridge component 90 and inner tube surface 84, and a second path 94 extends between upper surface 60 of bridge component 90 and inner tube surface 84. In some forms, second path 94 is radially oriented with first sidewall opening 68. In some forms, first path 92 is radially aligned with second side wall opening 70 and / or clearance slot 100. In use to mount the coil 14 to the delivery system 10, loop member 18 may be passed through first path 92 in a proximal direction and pull wire 30 may be passed through loop 18 and second path 94. In certain embodiments, loop member 18 is held against at least lower surface 62 of bridge component 90 with the coil 14 in its mounted condition. Loop 18 may also contact proximally facing surface 66 of bridge component 90 when secured by pull wire 30 with the coil 14 in its mounted condition. In some forms loop 18 may extend into or through a portion of first sidewall opening 68 with the coil 14 in its mounted condition. For example, loop 18 may be held against distal edge 150 of first sidewall opening 68. In certain embodiments, second path 94 and pull wire 30 are sized to provide a snug fit of pull wire 30 through second path 94 in order to prevent the portion of loop 18 positioned around pull wire 30 from passing between pull wire 30 and inner tube surface 84. In some forms, second path 94 and pull wire 30 are sized to leave a void space when pull wire 30 is positioned within second path 94, the void space comprising open space between the pull wire and innertube surface 84 radially aligned with the first sidewall opening 68. In accordance with certain embodiments, loop 18 comprises a 003620-002993 #3563408

[0065] 17 material having an outer diameter sized to prevent entry and passage through the void space.

[0066] The coil detachment interface member 44 can be formed from a single length of tube, for example a single length of metal (e.g. stainless steel) hypotube, which can have the same dimensional and / or other features described herein for hypotube materials of the delivery shaft 22. In some forms, bridge component 90 is mounted to coil detachment interface member which is otherwise formed from a single length of tube. The hypotube or other tube material used to form the coil detachment interface member 44 can be cut and formed to provide the disclosed coil detachment interface member features. Forming operations such as bending and stamping may be used, as examples. Coil detachment interface members formed from a single length of tube are advantageous in manufacture in that there is no need to assemble and attach a plurality of parts together to make the coil detachment interface members, which can be dimensionally small and thus present handling and attachment challenges. Coil detachment interface member 44 may also be manufactured using three-dimensional metal printing to reduce or eliminate the need for metal forming processes such as bending or stamping, while still providing a monolithic structure coil detachment interface member. It will be understood that coil detachment interface member 44 may also be manufactured by connecting (e.g. welding) multiple metal or other pieces together. Coil detachment interface member 44 can in certain aspects have a longitudinal length of no greater than about 10 mm, or no greater than about 5 mm, and typically in the range of about 1 mm to about 5mm or about 1 to about 3 mm. In accordance with some forms, bridge component 90 comprises a metallic wire or other suitable material. Interface member 44 may be formed having one or more adaptations for mounting bridge component 90.

[0067] In some forms, the interface body is formed having a first void and a second void comprising openings in the outer wall for mounting bridge component. First and second voids may be comprise one or more apertures in the outer wall of interface body 44, meaning the opening created by the void does not extend to the distal or proximal end 003620-002993 #3563408

[0068] 18 of the interface body. One embodiment of a coil detachment interface member having such apertures is illustrated in FIGs. 4, 5, 6a, and 6b. In the illustrated embodiment voids 160, 162 comprise apertures extending from an outer surface 86 of interface member 44 to inner surface 84. In this way, the bridge component is inserted transverse to the longitudinal axis of the interface body through the first and second voids. Alternatively, first and second voids may comprise slots extending from the distalmost end of the interface body. One embodiment of a coil detachment interface member having such slot voids is illustrated in FIGs. 7, 8, 9a, and 9b. In the illustrated embodiment voids 164, 166 comprise slot voids extending from an outer surface 86 of interface member 44 to inner surface 84, and open to distal end surface 56. Such a configuration provides for void openings 170, 172 along the circumference of the end surface which, along with clearance slot 100 when present, create gaps in the otherwise continuous circumferential end surface 56. In this way, the bridge component can be slid proximally into the first and second voids. It is within the scope of the disclosure to provide embodiments wherein the first and second void are dissimilar, for example in some forms one of the voids may comprise an aperture and the other a slot. Certain embodiments may only require a single void for mounting the bridge component. Once positioned, the bridge component is secured into place, for example by welding and / or adhesive.

[0069] In a detachment operation, the pull wire 30 is pulled proximally within the lumen 28 of delivery shaft 22 (e.g. after breaking the shaft 22 at location 40 when the abovediscussed release arrangement is present) until the distal end 32 of pull wire 30 passes through and proximally beyond the loop 18. This releases the loop 18 to movement distally through lumen 82 and out of the distal end 46 of coil detachment interface member 44. The coil device 14 is thereby detached from the delivery shaft 22. In one mode of use, prior to detachment of the coil device 14, the shaft 22 can be used to push the coil device 14 out of the distal end 302 of the catheter 300 at the target vascular site for delivery, with the coil device contacting vascular walls at the site and lodging in place. This operation may position the coil detachment interface member 44 distally beyond the distal end 302 of the catheter 300. The proximal movement of the pull wire 003620-002993 #3563408

[0070] 19

[0071] 30 and consequent detachment of the coil device 14 can then occur with the coil detachment interface member deployed beyond the distal end 302 of the catheter 300.

[0072] Embolic coil systems disclosed herein can have features of the embolic coil device, and of its condition as detachably connected to the delivery shaft, that facilitate a reliable detachment of the coil device from the shaft. Referring now again to FIGs. 1 to 9 and the system 10 described in conjunction therewith, the embolic coil device 14 in a relaxed (unstressed) condition (see e.g. FIGs. 10) has at least a segment 192 in which the windings 16 of the device are open windings wherein the surfaces of adjacent windings are longitudinally spaced from one another. Such longitudinal spacing can be a distance which can in some forms be equal to at least 10% of the diameter of the wire of the windings 16, or at least 20% of such diameter, and typically in the range of about 10% to about 200%, or about 20% to about 100%, of such diameter. In addition or alternatively, adjacent windings of the coil windings in segment 192, in the relaxed (longitudinally extended) condition, can be spaced a distance from one another in the range of about 0.0005 to about 0.15 mm. The open windings of coil device 14 are configured to act as a resilient, longitudinally compressible spring segment that can be longitudinally compressed to more closely approximate their adjacent surfaces and thereby shorten the coil device 14, and that when released from such compression resiliency expand to move their adjacent surfaces away from one another and lengthen the coil device 14, for example with the open windings resiliently expanding at least toward, and potentially to, their original open and spaced condition.

[0073] To connect the coil device 14 to the shaft 22, the loop 18 can be passed through the end 46 of the coil detachment interface member 44 that provides the end 24 of the shaft 22, and forced proximally through the first path 92 to a position proximal of bridge component 90. This can cause the proximal end 16A of the coil windings 16 to first contact the distally-facing surface 56 of the coil detachment interface member 44 whereupon continued proximal movement of the loop 18 resiliently compresses the open windings in segment 192 of coil device. The distal end 32 of the pull wire 30 can then be passed in a distally-directed movement through the loop 18 to connect the coil 003620-002993 #3563408

[0074] 20 device 14 to the delivery shaft 22, with the open windings of segment 192 retained in a resiliently compressed condition. In this detachably connected state, the proximal end 16A of the coil device 14 exerts a proximally-directed longitudinal force on the distal surface 56 of the coil detachment interface member 44. When, as discussed above, the pull wire 30 is thereafter retracted proximally to release loop 18 for detachment of the coil device 14, the resilient expansion of the opening windings of segment 92 can urge distal travel of the loop 18 through first path 92 and out of the end 24 of the delivery shaft 22. This can facilitate a more reliable detachment of the device 14 from the shaft 22. In the detachably connected condition of the embolic coil device 14 to the shaft 22, the distal end 32 of the pull wire 30 is positioned distal of the loop 18, preferably distal of the bridge component 90, and even more preferably distal of the distal end 24 of the delivery shaft 22 (e.g. positioned within the lumen defined by coil windings 16). In addition or alternatively, in some forms, the distal end 32 of the pull wire 30 may be retracted at least about 1 mm, or at least about 3 mm, and typically in the range of about 1 mm to about 10 mm, to cause detachment of the embolic coil device 14. It will be understood that corresponding embolic coil connection operations can be conducted with delivery shafts having the other bridge members disclosed herein.

[0075] Any suitable length segment and position of open windings of coil device 14 that function resiliently as discussed above can be utilized. In the illustrated embodiment, a preferred arrangement is depicted in which a first, proximal-most segment 190 of coil device 14 has windings that are relatively closed compared to the windings of segment 192 (having adjacent windings contacting one another and / or having a smaller longitudinal spacing than the windings of segment 192). The proximally-positioned relatively closed winding segment 190 facilitates a reliable interface between the proximal end 16A of coil windings 116 and the distally-facing surface 56 of the coil detachment interface member 44. The illustrated embolic coil device 14 also has a distal segment 194 having windings 16 that are relatively closed compared to the windings 16 of segment 192 (again, having adjacent windings contacting one another and / or having a smaller longitudinal spacing than the windings of segment 192). In other embodiments, all of the windings of the embolic coil device can be open, and thus 003620-002993 #3563408

[0076] 21 the entire length of the windings can participate in the resilient compression and expansion functions noted above, or the open winding segment can be positioned more proximally or more distally on the coil device 14 than that presently depicted, or multiple such open winding segments can be provided by the coil device 14. It will be preferred that the coil device 14 include such a resilient open winding segment (e.g. segment 192) in a region at or near the proximal end 16A of the coil windings 16, for example with the proximal end of the resilient open winding segment being within about 10 mm of proximal end 16A, for example where the proximal end of the resilient open winding segment is at proximal end 16A or is spaced distally from proximal end 16A a distance of about 0.2 to about 10 mm or in some forms about 0.5 to about 5 mm. The embolic coil device 14 also includes an element 96, such as a spherical or hemispherical member, attached to the distal end 16B of the coil windings 16 and providing a smooth distal end to the device 14.

[0077] The longitudinal length of the resilient open winding segment 192 or any other resilient open winding segment as described herein can be any suitable longitudinal length. In some forms, such longitudinal length will be at least about 1 mm, or at least about 2 mm, and typically in the range of about 1 mm to about 15 mm, more typically in the range of about 2 mm to about 8 mm.

[0078] Referring to FIG. 10, in some forms of the coil device 14 and systems including it, the filament 20 is connected to the coil windings 116 of the coil at location 100 that is just distal to the distal end of open winding segment 192, for example within about 3 mm, or within about 1 mm, of the distal end of open winding segment 192. For purposes of illustration, FIG. 10 shows location 100 having its coil windings resiliently forced open, as can be done to apply an adhesive or effect another attachment of filament 20 to the coil windings. It will be understood that the particular form of attachment of the filament to the coil windings 16 may vary depending on the materials used in the filament 20 and / or coil windings 16, for example the attachment may be achieved by a solder or weld or a bonding agent such as adhesive or glue in various embodiments. After achieving the 003620-002993 #3563408

[0079] 22 attachment, the windings at location 100 can be released to return to a more closed condition. In other forms, the coil windings at location 100 can be in a relatively open condition as depicted in FIG. 10 in a relaxed state. Attachment of the filament 20 to the coil windings at location 100 provides a feature wherein the coil windings 16 distal of location 100 are not subjected to the compression forces discussed above in connection with the loading and detachably connected condition of the coil device 14. This is because proximal urging of the loop 18 pulls on the coil windings 16 at position 100 but not on the coil windings 16 distal of location 100. In some embodiments the filament 20 may terminate at location 100. In preferred forms, the filament continues to the distal end of embolic coil device 14 and is also attached to the coil windings at location 104. The filament can thus provide stretch resistance to the embolic coil device 14 between locations 100 and 104, for example during delivery operations prior to detachment and / or after detachment at the target site. It will be understood as well that the segment of filament 20 extending between location 100 and loop 18 will, in the detachably connected condition of the embolic coil device (e.g. during maneuvering to or at the target site for coil delivery), provide stretch resistance to the length of coil device 14 positioned proximally of location 100.

[0080] The delivery systems 10 described herein can be used to deliver the coil device 14, to an aneurysm in a blood vessel. In doing so, the catheter 300 (e.g. microcatheter) can be positioned within the vessel so as to place its distal end 302 within the aneurysm. The delivery system 10 including the delivery shaft 22, and the detachably connected coil device 14, is then advanced through the catheter 300. The system 10, may be pre- loaded in an introducer sheath or the like (not shown). The system 10 is then advanced to place the coil device 14 in the aneurysm. One or more radiopaque markers located on the delivery system 10 and / or catheter 300 may be used to aid the physician in positioningthe system 10 for deployment of the coil device 14. The coil device 14 can then be released into the aneurysm by proximal retraction of the pull wire 30. Where the system 10 includes an arrangement for protecting against unintended release of the coil device 14 as discussed above, prior to proximal retraction of the pull wire 30, the 003620-002993 #3563408

[0081] 23 shaft 22 is broken at location 40 by applying bending forces to the shaft 22 across location 40.

[0082] ENUMERATED LISTING OF CERTAIN EMBODIMENTS HEREIN

[0083] The following provides a non-limiting, enumerated listing of certain Embodiments herein.

[0084] 1. A coil detachment interface member for a system for delivering an embolic coil device, comprising: an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis; a bridge component having a rounded external profile and mounted to the outer wall, the bridge component extending transversely to the longitudinal axis of the interface body; a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device; a second path positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire; a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of and proximate to a proximal surface of the bridge component; and a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge ofthe interface body.

[0085] 2. The device of embodiment 1, wherein the outer wall is tubular.

[0086] 3. The device of any one ofthe preceding embodiments, also comprising a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening along the longitudinal axis of the interface body, and wherein a portion of the second sidewall opening occurs proximal of and proximate to the proximal surface of the bridge component. 003620-002993 #3563408

[0087] 24

[0088] 4. The device of embodiment 3, wherein the second sidewall opening and the clearance slot are radially aligned along the length of the interface body.

[0089] 5. The device of any one of the preceding embodiments, wherein the interface body comprises a first mounting void and a second mounting void, and wherein said bridge component is mounted in said first and second mounting voids.

[0090] 6. The device of embodiment 5, wherein the first mounting void comprises a first slot extending from a distal end of the interface body.

[0091] 7. The device of embodiment 6, wherein the second mounting void comprises a second slot extending from the distal end of the interface body.

[0092] 8. The device of embodiment 5, wherein the first mounting void comprises an aperture in the outer wall.

[0093] 9. The device of any one of embodiments 6 or 8, wherein the second mounting void comprises an aperture in the outer wall.

[0094] 10. The device of any one of the preceding embodiments, wherein the interface body also includes a tubular segment distal of the bridge component and defining a proximally- facing partially circumferential surface.

[0095] 11. A system for delivering an embolic coil device, comprising: a flexible elongate delivery shaft defining a lumen and having a distal region; a coil detachment interface member at the distal region of the flexible elongate delivery shaft, the coil detachment interface member including: an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis; 003620-002993 #3563408

[0096] 25 a bridge component having a rounded external profile and mounted to the outer wall, the bridge component extending transversely to the longitudinal axis of the interface body; a first path positioned to a first side of the bridge component; a second path positioned to a second side of the bridge component; a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of a proximate to a proximal surface of the bridge component; a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge if the interface body; an embolic coil device detachably connected to the distal region of the elongate delivery shaft and having a loop member received through the first path; a pull wire extending through the lumen of the elongate delivery shaft and received through the loop member and the second path to attach the embolic coil device to the elongate delivery shaft; and wherein proximal retraction of the pull wire causes detachment of the embolic coil device from the elongate delivery shaft.

[0097] 12. The system of embodiment 11, wherein the outer wall is tubular.

[0098] 13. The system of any one of embodiments 11 or 12, also comprising a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening along the longitudinal axis of the interface body and wherein a portion of the second sidewall opening occurs proximal of and proximate to the proximal surface of the bridge component.

[0099] 14. The system of embodiment 13, wherein the second sidewall opening and the clearance slot are radially aligned along the length of the interface body.

[0100] 15. The system of any one of embodiments 11 to 14, wherein the loop member is defined by a filament extending into a lumen of the embolic coil device, preferably wherein 003620-002993 #3563408

[0101] 26 the filament provides stretch resistance to the embolic coil device at least until said detachment.

[0102] 16. The system of any one of embodiments 11 to 15, wherein the interface body comprises a first mounting void and a second mounting void, and wherein said bridge component is mounted in said first and second mounting voids.

[0103] 17. The system of embodiment 16, wherein the first mounting void comprises a first slot extending from a distal end of the interface body.

[0104] 18. The system of embodiment 17, wherein the second mounting void comprises a second slot extending from the distal end of the interface body.

[0105] 19. The system of embodiment 16, wherein the first mounting void comprises an aperture in the outer wall.

[0106] 20. The system of any one of embodiments 17 or 19, wherein the second mounting void comprises an aperture in the outer wall.

[0107] 21. The system of any one of the preceding embodiments, wherein the interface body also includes a tubular segment distal of the bridge component and defining a proximally- facing partially circumferential surface, and wherein a proximal end of the embolic coil device abuts the distally-facing partially circumferential surface.

[0108] 22. The system of any one of embodiments 11 to 21, wherein a proximal end of the loop member is held at a position proximal of the bridge component, until said proximal retraction of the pull wire.

[0109] 23. The system of embodiment 22, wherein the proximal end of the loop member is held against a distal edge of the first sidewall opening, until said proximal retraction of the pull wire. 003620-002993 #3563408

[0110] 21

[0111] 25. The system of any one of embodiments 11 to 24, wherein the pull wire has a distal end positioned distal of the bridge component.

[0112] 26. The system of embodiment 25, wherein the distal end of the pull wire is positioned distal of the distalmost leading edge of the interface body. 1. A coil detachment interface member for a system for delivering an embolic coil device, comprising: an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis; a bridge component mounted to the outer wall, the bridge component extending transverse to the longitudinal axis of the interface body; a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device, and a second path positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire, wherein at least one of the first path and the second path occurs between a surface of the bridge component and an inner surface of the outer wall; a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of and proximate to a proximal surface of the bridge component; and a mount arrangement in which the bridge component is mounted in opposed first and second voids in the outer wall.

[0113] 28. The device of embodiment 27, wherein the outer wall is tubular.

[0114] 29. The device of any one of embodiments 27 or 28, comprising: a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge ofthe interface body. 003620-002993 #3563408

[0115] 28

[0116] 30. The device of any one of embodiments 27 to 29, also comprising a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening along the longitudinal axis of the interface body and wherein a portion of the second sidewall opening occurs proximal of and proximate to the proximal surface of the bridge component.

[0117] 31. The device of embodiment 30 as dependent on embodiment 29, wherein the second sidewall opening and the clearance slot are radially aligned along the length of the interface body.

[0118] 32. The device of any one of embodiments 27 to 31, wherein the first void comprises a first slot extending from a distal end of the interface body.

[0119] 33. The device of embodiment 32, wherein the second void comprises a second slot extending from the distal end of the interface body.

[0120] 34. The device of any one of embodiments 1 to 31, wherein the first void comprises an enclosed opening in the outer wall.

[0121] 35. The device of any one of embodiments 32 or 34, wherein the second mounting void comprises an enclosed opening in the outer wall.

[0122] 36. The device of any one of the preceding embodiments, wherein the interface body also includes a tubular segment distal of the bridge component and defining a proximally- facing partially circumferential surface.

[0123] 37. The device of any one of embodiments 27 to 36, the bridge component having a rounded external profile.

[0124] 38. A system for delivering an embolic coil device, comprising: a flexible elongate delivery shaft defining a lumen and having a distal region; 003620-002993 #3563408

[0125] 29 a coil detachment interface member at the distal region of the flexible elongate delivery shaft, the coil detachment interface member including: an interface body having an outer wall, and a longitudinal axis; a bridge component mounted to the outer wall, the bridge component extending transversely to the longitudinal axis of the interface body; a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device, and a second path positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire, wherein at least one of the first path and the second path occurs between a surface of the bridge component and an inner surface of the outer wall; a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of a proximate to a proximal surface of the bridge component; and a mount arrangement in which the bridge component is mounted in opposed first and second voids in the outer wall; an embolic coil device detachably connected to the distal region of the elongate delivery shaft and having a loop member received through the first path; a pull wire extending through the lumen of the elongate delivery shaft and received through the loop member and the second path to attach the embolic coil device to the elongate delivery shaft; and wherein proximal retraction of the pull wire causes detachment of the embolic coil device from the elongate delivery shaft.

[0126] 39. The system of embodiment 38, wherein the outer wall is tubular.

[0127] 40. The system of any one of embodiments 38 or 39, comprising: a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge of the interface body.

[0128] 41. The system of any one of embodiments 38 to 40, also comprising a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the 003620-002993 #3563408

[0129] 30 first sidewall opening along the longitudinal axis of the interface body and wherein a portion of the second sidewall opening occurs proximal of and proximate to the proximal surface of the bridge component.

[0130] 42. The system of embodiment 41 as dependent on embodiment 40, wherein the second sidewall opening and the clearance slot are radially aligned along the length of the interface body.

[0131] 43. The system of any one of embodiments 38 to 42, wherein the loop member is defined by a filament extending into a lumen of the embolic coil device, preferably wherein the filament provides stretch resistance to the embolic coil device at least until said detachment.

[0132] 44. The system of any one of embodiments 38 to 43, wherein the first void comprises a first slot extending from a distal end of the interface body.

[0133] 45. The system of embodiment 44, wherein the second void comprises a second slot extending from the distal end of the interface body.

[0134] 46. The system of any one of embodiments 38 to 43, wherein the first void comprises an aperture in the outer wall.

[0135] 47. The system of any one of embodiments 44 or 46, wherein the second mounting void comprises an aperture in the outer wall.

[0136] 48. The system of any one of embodiments 38 to 47, wherein the interface body also includes a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface, and wherein a proximal end of the embolic coil device abuts the distally-facing partially circumferential surface. 003620-002993 #3563408

[0137] 31

[0138] 49. The system of any one of embodiments 38 to 48, wherein a proximal end of the loop member is held at a position proximal of the bridge component, until said proximal retraction of the pull wire.

[0139] 50. The system of any one of embodiments 38 to 49, wherein the pull wire has a distal end positioned distal of the bridge component.

[0140] 51. The system of embodiment 50, wherein the distal end of the pull wire is positioned distal of the distalmost leading edge of the interface body.

[0141] 52. The system of any one of embodiments 38 to 51, the bridge component having a rounded external profile.

[0142] 53. The device of any one of embodiments 3, or 30, or the system of any one of embodiments 13, or 41, wherein a first segment of the outer wall defines a first longitudinally extending strut, the first longitudinally extending strut extending radially between the first sidewall opening and the second sidewall opening, and wherein a second segment of the outer wall defines a second longitudinally extending strut, the second longitudinally extending strut extending radially between the first sidewall opening and the second sidewall opening opposite the first longitudinally extending strut.

[0143] 54. The device of any one of embodiments 4, or 31, or the system of any one of embodiments 14, or 42, wherein a support strut extends between a proximal wall of the clearance slot and a distal wall of the second sidewall opening.

[0144] The uses of the terms "a" and "an" and "the" and similar references herein (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were 003620-002993 #3563408

[0145] 32 individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., "such as") provided herein, is intended merely to better illuminate embodiments of the disclosure and does not pose a limitation on the scope of the disclosure unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the products or methods defined by the claims.

[0146] While embodiments of the disclosure have been illustrated and described in detail in the drawings and foregoing description, the same is to be considered as illustrative and not restrictive in character, it being understood that only some embodiments have been shown and described and that all changes and modifications that come within the spirit of the disclosures herein are desired to be protected.

Claims

003620-002993 #356340833CLAIMSWhat is claimed is:

1. A coil detachment interface member for a system for delivering an embolic coil device, comprising: an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis; a bridge component having a rounded external profile and mounted to the outer wall, the bridge component extending transversely to the longitudinal axis of the interface body; a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device; a second path positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire; a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of and proximate to a proximal surface of the bridge component; and a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge ofthe interface body.

2. The device of claim 1, wherein the outer wall is tubular.

3. The device of any one ofthe preceding claims, also comprising a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening along the longitudinal axis of the interface body, and wherein a portion of the second sidewall opening occurs proximal of and proximate to the proximal surface of the bridge component.

4. The device of claim 3, wherein the second sidewall opening and the clearance slot are radially aligned along the length of the interface body.003620-002993 #3563408345. The device of any one of the preceding claims, wherein the interface body comprises a first mounting void and a second mounting void, and wherein said bridge component is mounted in said first and second mounting voids.

6. The device of claim 5, wherein the first mounting void comprises a first slot extending from a distal end of the interface body.

7. The device of claim 6, wherein the second mounting void comprises a second slot extending from the distal end of the interface body.

8. The device of claim 5, wherein the first mounting void comprises an aperture in the outer wall.

9. The device of any one of claims 6 or 8, wherein the second mounting void comprises an aperture in the outer wall.

10. The device of any one of the preceding claims, wherein the interface body also includes a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface.

11. A system for delivering an embolic coil device, comprising: a flexible elongate delivery shaft defining a lumen and having a distal region; a coil detachment interface member at the distal region of the flexible elongate delivery shaft, the coil detachment interface member including: an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis; a bridge component having a rounded external profile and mounted to the outer wall, the bridge component extending transversely to the longitudinal axis of the interface body; a first path positioned to a first side of the bridge component; a second path positioned to a second side of the bridge component;003620-002993 #356340835 a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of a proximate to a proximal surface of the bridge component; a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge if the interface body; an embolic coil device detachably connected to the distal region of the elongate delivery shaft and having a loop member received through the first path; a pull wire extending through the lumen of the elongate delivery shaft and received through the loop member and the second path to attach the embolic coil device to the elongate delivery shaft; and wherein proximal retraction of the pull wire causes detachment of the embolic coil device from the elongate delivery shaft.

12. The system of claim 11, wherein the outer wall is tubular.

13. The system of any one of claims 11 or 12, also comprising a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening alongthe longitudinal axis of the interface body and wherein a portion of the second sidewall opening occurs proximal of and proximate to the proximal surface of the bridge component.

14. The system of claim 13, wherein the second sidewall opening and the clearance slot are radially aligned along the length of the interface body.

15. The system of any one of claims 11 to 14, wherein the loop member is defined by a filament extending into a lumen of the embolic coil device, preferably wherein the filament provides stretch resistance to the embolic coil device at least until said detachment.

16. The system of any one of claims 11 to 15, wherein the interface body comprises a first mounting void and a second mounting void, and wherein said bridge component is mounted in said first and second mounting voids.003620-002993 #35634083617. The system of claim 16, wherein the first mounting void comprises a first slot extending from a distal end of the interface body.

18. The system of claim 17, wherein the second mounting void comprises a second slot extending from the distal end of the interface body.

19. The system of claim 16, wherein the first mounting void comprises an aperture in the outer wall.

20. The system of any one of claims 17 or 19, wherein the second mounting void comprises an aperture in the outer wall.

21. The system of any one of the preceding claims, wherein the interface body also includes a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface, and wherein a proximal end of the embolic coil device abuts the distally-facing partially circumferential surface.

22. The system of any one of claims 11 to 21, wherein a proximal end of the loop member is held at a position proximal of the bridge component, until said proximal retraction of the pull wire.

23. The system of claim 22, wherein the proximal end of the loop member is held against a distal edge of the first sidewall opening, until said proximal retraction of the pull wire.

25. The system of any one of claims 11 to 24, wherein the pull wire has a distal end positioned distal of the bridge component.

26. The system of claim 25, wherein the distal end of the pull wire is positioned distal of the distalmost leading edge of the interface body.003620-002993 #35634083727. A coil detachment interface member for a system for delivering an embolic coil device, comprising: an interface body having a proximal end, a distal end, an outer wall, and a longitudinal axis; a bridge component mounted to the outer wall, the bridge component extending transverse to the longitudinal axis of the interface body; a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device, and a second path positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire, wherein at least one of the first path and the second path occurs between a surface of the bridge component and an inner surface of the outer wall; a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of and proximate to a proximal surface of the bridge component; and a mount arrangement in which the bridge component is mounted in opposed first and second voids in the outer wall.

28. The device of claim T1 , wherein the outer wall is tubular.

29. The device of any one of claims Tl or 28, comprising: a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge ofthe interface body.

30. The device of any one of claims 27 to 29, also comprising a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening alongthe longitudinal axis of the interface body and wherein a portion of the second sidewall opening occurs proximal of and proximate to the proximal surface of the bridge component.003620-002993 #35634083831. The device of claim 30 as dependent on claim 29, wherein the second sidewall opening and the clearance slot are radially aligned along the length of the interface body.

32. The device of any one of claims 27 to 31, wherein the first void comprises a first slot extending from a distal end of the interface body.

33. The device of claim 32, wherein the second void comprises a second slot extending from the distal end of the interface body.

34. The device of any one of claims 27 to 31, wherein the first void comprises an enclosed opening in the outer wall.

35. The device of any one of claims 32 or 34, wherein the second mounting void comprises an enclosed opening in the outer wall.

36. The device of any one of the preceding claims, wherein the interface body also includes a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface.

37. The device of any one of claims 27 to 36, the bridge component having a rounded external profile.

38. A system for delivering an embolic coil device, comprising: a flexible elongate delivery shaft defining a lumen and having a distal region; a coil detachment interface member at the distal region of the flexible elongate delivery shaft, the coil detachment interface member including: an interface body having an outer wall, and a longitudinal axis; a bridge component mounted to the outer wall, the bridge component extending transversely to the longitudinal axis of the interface body; a first path positioned to a first side of the bridge component for receiving therethrough a loop member connected to an embolic coil device, and a second path003620-002993 #356340839 positioned to a second side of the bridge component opposite the first side for receiving therethrough a pull wire, wherein at least one of the first path and the second path occurs between a surface of the bridge component and an inner surface of the outer wall; a first sidewall-opening in the outer wall, the first sidewall opening having a first opening portion occurring proximal of a proximate to a proximal surface of the bridge component; and a mount arrangement in which the bridge component is mounted in opposed first and second voids in the outer wall; an embolic coil device detachably connected to the distal region of the elongate delivery shaft and having a loop member received through the first path; a pull wire extending through the lumen of the elongate delivery shaft and received through the loop member and the second path to attach the embolic coil device to the elongate delivery shaft; and wherein proximal retraction of the pull wire causes detachment of the embolic coil device from the elongate delivery shaft.

39. The system of claim 38, wherein the outer wall is tubular.

40. The system of any one of claims 38 or 39, comprising: a clearance slot in the outer wall independent of the first sidewall opening and extending proximally from a distalmost leading edge of the interface body.

41. The system of any one of claims 38 to 40, also comprising a second sidewall opening in the outer wall, the second sidewall opening co-extending at least partly with the first sidewall opening alongthe longitudinal axis of the interface body and wherein a portion of the second sidewall opening occurs proximal of and proximate to the proximal surface of the bridge component.

42. The system of claim 41 as dependent on claim 40, wherein the second sidewall opening and the clearance slot are radially aligned along the length of the interface body.003620-002993 #35634084043. The system of any one of claims 38 to 42, wherein the loop member is defined by a filament extending into a lumen of the embolic coil device, preferably wherein the filament provides stretch resistance to the embolic coil device at least until said detachment.

44. The system of any one of claims 38 to 43, wherein the first void comprises a first slot extending from a distal end of the interface body.

45. The system of claim 44, wherein the second void comprises a second slot extending from the distal end of the interface body.

46. The system of any one of claims 38 to 43, wherein the first void comprises an aperture in the outer wall.

47. The system of any one of claims 44 or 46, wherein the second mounting void comprises an aperture in the outer wall.

48. The system of any one of claims 38 to 47, wherein the interface body also includes a tubular segment distal of the bridge component and defining a proximally-facing partially circumferential surface, and wherein a proximal end of the embolic coil device abuts the distally-facing partially circumferential surface.

49. The system of any one of claims 38 to 48, wherein a proximal end of the loop member is held at a position proximal of the bridge component, until said proximal retraction of the pull wire.

50. The system of any one of claims 38 to 49, wherein the pull wire has a distal end positioned distal of the bridge component.

51. The system of claim 50, wherein the distal end of the pull wire is positioned distal of the distalmost leading edge of the interface body.003620-002993 #35634084152. The system of any one of claims 38 to 51, the bridge component having a rounded external profile.

53. The device of any one of claims 3, or 30, or the system of any one of claims 13, or 41, wherein a first segment of the outer wall defines a first longitudinally extending strut, the first longitudinally extending strut extending radially between the first sidewall opening and the second sidewall opening, and wherein a second segment of the outer wall defines a second longitudinally extending strut, the second longitudinally extending strut extending radially between the first sidewall opening and the second sidewall opening opposite the first longitudinally extending strut.

54. The device of any one of claims 4, or 31, or the system of any one of claims 14, or 42, wherein a support strut extends between a proximal wall of the clearance slot and a distal wall of the second sidewall opening.

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