Generator for separating yttrium [ 90y] from strontium [ 90sr]-containing mother liquor, and separation method

Abstract

The present invention relates to the technical field of isotopes, and specifically relates to a generator for separating yttrium [90Y] from a strontium [90Sr]-containing mother liquor, and a separation method. The separation method comprises the following steps: adding a strontium [90Sr]-containing mother liquor to a resin separation column, using an eluent for elution, collecting a strontium [90Sr]-containing eluent, and then using air to evacuate liquid in the resin separation column; evaporating the strontium [90Sr]-containing eluent at 85-95°C, dissolving the product, letting the solution stand, and collecting a strontium [90Sr]-yttrium [90Y] eluent, and adding same to the strontium [90Sr]-containing mother liquor for circulation; and using an eluent for elution, and collecting an yttrium [90Y]-containing eluent. According to the present invention, by adjusting the evaporation temperature of a strontium [90Sr]-containing eluent, the loss of strontium [90Sr] can be greatly avoided without affecting the separation effect of yttrium [90Y].

Description

A method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 Y] generator and separation method

[0001] Related applications

[0002] This application claims priority to Chinese Patent Application No. 2024119199913, filed on December 24, 2024, entitled “A generator and separation method for separating yttrium [90Y] from strontium [90Sr] mother liquor”. Technical Field

[0003] This invention relates to the field of isotope technology, specifically to a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 Y] generator and separation method. Background Technology

[0004] yttrium[ 90 Yttrium (Y) is a pure beta radioactive nuclide with a half-life of 64 hours. The beta rays produced during its decay can reach a maximum energy of 2.28 MeV. 90 decay daughters of Y] 90 Zr is stable and non-toxic, and will not affect the human body. Furthermore, yttrium […]. 90 Y] possesses excellent chelating chemical properties, making it easy to label monoclonal antibodies, microspheres, peptides, etc., for in vivo radiotherapy of cancer. Contains yttrium [ 90 Radioactive microspheres containing yttrium [γ] have a very small radiation radius. Using interventional techniques, these microspheres are injected into the liver. 90 Radioactive microspheres of Y[[] can provide continuous radiation therapy to the entire liver cancer cell line, leading to cancer cell necrosis. Furthermore, due to the small radiation radius of each microsphere, it has almost no killing effect on surrounding normal tissue. This precise radiotherapy method can more effectively kill cancer cells while causing less damage to normal tissue. Therefore, medical yttrium[[ 90 The production of Y-nuclides is of great significance for radiotherapy of liver cancer.

[0005] Medical Yttrium 90 The main production methods for Y-type nuclides include reactors, nuclide generators, and accelerators. Among these, the production of strontium-based nuclides involves... 90 Sr]-Yttrium[ 90 Y] generator produces yttrium[ 90 Y] has the advantages of simple and quick operation and no regional restrictions, and the raw material used is strontium [ 90 Sr] is 235 U's fission products can be obtained from spent fuel that has been cooled for a long time, and are currently the main source of yttrium production. 90 The main method of Y]. Strontium [ 90 Sr]-Yttrium[90 The preparation methods for Y] generators mainly include extraction, chromatography, precipitation, electrodeposition, and liquid film methods. However, these methods are complex to operate, generate large amounts of radioactive waste liquid, and the parent yttrium [ 90 [Y] is a highly toxic osteophilic nuclide with a half-life of up to 28.5 years. Its absorption in human bone is strictly limited, therefore, strontium [ 90 Sr]-Yttrium[ 90 The separation of Y] requires high precision, and currently, from strontium[ 90 Separation and purification of yttrium from Sr] 90 The mature technologies of Y] are mainly controlled by foreign countries, and yttrium[ 90 The production and supply of strontium [Y] is entirely dependent on imports; therefore, the development of strontium [Y] with independent intellectual property rights in China is crucial. 90 Sr]-Yttrium[ 90 The Y generator is of great significance.

[0006] Currently, the separation of strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The generator of Y] mainly contains strontium[ 90 The recovery rate of Sr was low, and it contained yttrium. 90 Strontium in the eluent [Y] 90 Sr]-Yttrium[ 90 The problem includes high radioactivity of Y and a short lifespan of the generator. Summary of the Invention

[0007] To solve the above-mentioned technical problems, the present invention provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The present invention relates to a generator and separation method for strontium-containing [Y]. 90 Adjusting the temperature of the leaching solution for Sr can greatly prevent the evaporation of Sr. 90 The loss of Sr] will not affect the yttrium[ 90 The separation effect of Y].

[0008] Therefore, the present invention provides the following technical solution:

[0009] In a first aspect, the present invention, in an optional embodiment, provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method of Y] includes the following steps:

[0010] S1: To make strontium-containing [ 90 The mother liquor was passed through a resin separation column to separate the yttrium [Sr] from the mother liquor. 90 [Y] is adsorbed, and the strontium on the resin separation column is removed using the eluent. 90 Sr was rinsed to collect strontium-containing [ 90The eluent of Sr] is then purged from the resin separation column with air;

[0011] S2: For strontium-containing [ 90 The eluent of Sr was evaporated at 85-95℃ to obtain strontium [ 90 The crystals of Sr were dissolved using a leaching solution, and after standing for 8-12 days, the leaching solution was collected and added to a strontium-containing […]. 90 Sr] is circulated in the mother liquor;

[0012] S3: Use eluent to remove yttrium from the resin separation column. 90 Y] was eluted to collect yttrium-containing [ 90 The elution buffer of Y];

[0013] Among them, the yttrium-containing [ 90 In the eluent of Y], strontium[ 90 Sr]-Yttrium[ 90 The radioactivity ratio of Y] is less than 10. -6 .

[0014] Strontium-containing 90 When the eluent of Sr is evaporated and recovered, it will cause strontium [ 90 The present invention addresses the loss of strontium-containing [Sr] by […]. 90 Adjusting the temperature of the leaching solution for Sr can greatly prevent the evaporation of Sr. 90 The loss of Sr] will not affect the yttrium[ 90 The separation effect of Y].

[0015] Preferably, the method further includes: processing yttrium-containing [ 90 The eluent of Y] is then adsorbed using at least one set of resin separation columns. The resin separation columns are eluted with the eluent, and the purified yttrium-containing [Y] is collected. 90 The eluent for [Y]. Furthermore, for yttrium-containing [ 90 The eluent of Y] was then adsorbed onto a set of resin separation columns. The resin separation columns were eluted with the eluent, and the purified yttrium-containing [Y] was obtained. 90 In the eluent of Y], strontium[ 90 Sr]-Yttrium[ 90 The radioactivity ratio of Y] is less than 10. -7 For yttrium-containing [ 90 The eluent of Y] was then adsorbed onto two sets of resin separation columns. The resin separation columns were eluted with the eluent, and the purified yttrium-containing [Y] was obtained. 90 In the eluent of Y], strontium[ 90 Sr]-Yttrium[ 90 The radioactivity ratio of Y] is less than 10. -8 .

[0016] In this invention, by processing yttrium-containing [ 90 The eluent of Y can be purified multiple times to reduce the yttrium content. 90 Strontium in the eluent of Y] 90 Sr]-Yttrium[ 90 The radioactivity of Y].

[0017] Preferably, the total volume of the eluent used is at least 11 times the volume of the resin separation column; the elution rate is 0.25-1 mL / min; the concentration of the eluent is 1 mol / L, and the eluent is selected from nitric acid, sulfuric acid or hydrochloric acid; the concentration of the elution solution is 8 mol / L, and the elution solution is selected from nitric acid, sulfuric acid or hydrochloric acid.

[0018] Secondly, in an optional embodiment, the present invention provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The generator of Y] includes a mother liquor tank, a rinsing tank, a first elution tank, a second elution tank, an automatic separation device, and an evaporation recovery device. The automatic separation device includes a first separation column, a connecting device, a first injection pump, and a second injection pump.

[0019] The connecting device is used to selectively connect the mother liquor tank, rinsing tank, first elution tank, second elution tank, first separation column, first injection pump, and second injection pump.

[0020] The mother liquor tank is used to supply strontium-containing [[ 90 Sr] mother liquor, and then the first separation column is used to separate the strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 Y] is adsorbed;

[0021] The first injection pump is used to draw eluent from the eluent tank to eluent the first separation column, and the strontium adsorbed on the first separation column is eluented. 90 Sr] is fed into the evaporation and recovery device in the form of a solution;

[0022] The second injection pump is used to draw eluent from the first elution tank to elute the first separation column, eluting the yttrium adsorbed on the first separation column. 90 Y] is fed into the second elution tank in the form of a solution;

[0023] The resin used in the first separation column is CL-P204 elution resin with a pore size of 80-150 mesh.

[0024] In this invention, by selecting CL-P204 extraction resin as the separation resin for the first separation column, yttrium […] can be […]. 90 Y] is completely adsorbed in the resin, while strontium[90 Sr] flows out directly. Due to yttrium [ 90 The extremely low chemical content of strontium [Y] significantly reduces the amount of resin used, allowing for a more concentrated design of the separation column and local shielding device. 90 The direct efflux of Sr and the reduced irradiation of the resin material increase the amount of Sr. 90 Sr]-Yttrium[ 90 The lifespan of the Y generator.

[0025] Preferably, the evaporation recovery device includes an inlet pipe, an evaporating dish, a baffle, an outlet, and a heating device; the baffle is located inside the evaporating dish and is used to prevent strontium from […]. 90 The strontium (Sr) solution splashes during evaporation, and the baffle has small holes for the exhaust of evaporated gas; the inlet pipe runs through the baffle, with one end connected to the connecting device and the rinsing tank, and the other end suspended above the bottom of the evaporating dish; the outlet is located on one side of the outer surface of the evaporating dish and connected to the mother liquor tank; the heating device is located at the bottom of the evaporating dish for heating the strontium (Sr) solution inside the evaporating dish. 90 The Sr solution was heated.

[0026] In this invention, strontium [ 90 After the Sr effluent reaches the evaporation and recovery unit, it undergoes concentration and conversion before re-entering the automatic separation unit for direct subsequent Sr […]. 90 Sr] and yttrium 90 Separation of Y], thereby ensuring the separation of strontium[ 90 The high recovery rate of Sr is used to extend the lifespan of Sr. 90 Sr]-Yttrium[ 90 The lifespan of the Y generator.

[0027] Preferably, the connecting device includes a first six-way valve, a second six-way valve, and a third six-way valve; the common port C of the first six-way valve is connected to the inlet of the first separation column, port 1# is connected to port 1# of the second six-way valve, port 2# is connected to the first elution tank via the second injection pump, port 3# is connected to port 3# of the second six-way valve, port 4# is connected to the rinsing tank via the first injection pump, port 5# is connected to air, and port 6# is connected to port 4# of the second six-way valve; port 2# of the second six-way valve is connected to the mother liquor tank, and its common port C is connected to the inlet of the first separation column; the common port C of the third six-way valve is connected to the outlet of the first separation column, port 1# of the third six-way valve is connected to the inlet pipe of the evaporation recovery device, and port 2# of the third six-way valve is connected to the second elution tank.

[0028] In this invention, the central holes of the first, second, and third six-way valves serve as a common channel, allowing for multi-channel switching via a rotor to facilitate the alternating passage of different solutions. The flow channel diameter is 1.2 mm, the port-to-port volume is 27.5 μL, the rotor slot volume is 5.41 μL, the liquid contact material is PCTEF or sapphire, and the tubing interface is a 1 / 4-28 UNF threaded connector. The switching time is less than 4 seconds per revolution, and the maximum driving force is 4 N / m. The design accuracy error of the first and second injection pumps is less than 1%, and the volume repeatability error is 0.3%-0.5%. Depending on the actual application, different specifications of injectors from 50 μL to 10 mL can be selected. The tubing interface is a 1 / 4-28 UNF threaded connector, and the rated stroke running time is 2 seconds to 12000 seconds (pure water medium). The control unit controls the first, second, and third six-way valves, the first and second injection pumps, and includes a 485 hub and a miniature touchscreen. The first six-way valve, second six-way valve, third six-way valve, first injection pump, and second injection pump communicate via a 485 hub and a miniature touchscreen. The host computer software sends control commands to the 485 hub via the computer's serial port, and the hub then distributes the commands to each device, thereby controlling the hardware. The sealing material for the first separation column cover is thermoplastic polyurethane elastomer rubber, and the intermediate threads are made of polyetheretherketone (PEEK).

[0029] Preferably, the generator further includes at least one set of separation columns for processing the yttrium eluted from the first separation column. 90 The solution is eluted again; the inlet of each separation column is connected to the first elution tank; the resin of at least one separation column is CL-P204 extraction resin.

[0030] In this invention, yttrium adsorbed in the first separation column [ 90 Y] was eluted to obtain yttrium[ 90 The crude product of Y], yttrium[ 90 The eluent is then passed through at least one set of separation columns, with the selected CL-P204 extraction resin adsorbing yttrium. 90 Trace impurities in Y] to achieve yttrium [ 90 Further purification of the crude product [Y] to increase the yttrium content in the product. 90 The radiochemical purity of Y can be improved. It can also enhance the radiochemical purity of strontium. 90 The recovery rate of Sr is improved without affecting the recovery rate of yttrium. 90 The separation effect of Y].

[0031] Preferably, the generator further includes a control unit; the control unit is signal-connected to the communication device, the first injection pump, and the second injection pump; the liquid contact material of the communication device is selected from polychlorotrifluoroethylene or sapphire; the evaporating dish is made of polyetheretherketone; and the liquid volume accuracy error of the first injection pump and the second injection pump is less than 1%.

[0032] In this invention, a control unit is used to control the flow rate and direction of different liquids by controlling the connecting device and each injection pump, thereby realizing the separation and recovery process remotely, ensuring the separation effect and reducing the radiation dose to personnel.

[0033] Compared with the prior art, the present invention has one of the following beneficial effects:

[0034] 1. This invention, by selecting an extraction resin as the separating resin in the first separation column, can […]. 90 Y] is completely adsorbed in the resin, while strontium[ 90 Sr] flows out directly. Due to yttrium [ 90 The extremely low chemical content of strontium [Y] significantly reduces the amount of resin used, allowing for a more concentrated design of the separation column and local shielding device. 90 The direct efflux of Sr and the reduced irradiation of the resin material increase the amount of Sr. 90 Sr]-Yttrium[ 90 The lifespan of the Y generator.

[0035] 2. Strontium 90 After the Sr effluent reaches the evaporation and recovery unit, it undergoes concentration and conversion before re-entering the automatic separation unit for direct subsequent Sr […]. 90 Sr] and yttrium 90 Separation of Y], thereby ensuring the separation of strontium[ 90 The high recovery rate of Sr is used to extend the lifespan of Sr. 90 Sr]-Yttrium[ 90 The lifespan of the Y generator.

[0036] 3. For automatic separation devices, control units are used to control the flow rate and direction of different liquids by controlling each six-way valve and each injection pump, so as to realize the separation and recovery process remotely, ensuring the separation effect and reducing the radiation dose to personnel.

[0037] 4. This invention utilizes yttrium adsorbed in the first separation column... 90 Y] was eluted to obtain yttrium[ 90 The crude product of Y], yttrium[ 90 The eluent then passes through a second separation column, where the selected extraction resin adsorbs yttrium. 90 Trace impurities in Y] to achieve yttrium [ 90 Further purification of the crude product [Y] to increase the yttrium content in the product.90 The radiochemical purity of Y]. Attached Figure Description

[0038] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0039] Figure 1 is a schematic diagram of the generator according to Embodiment 1 of the present invention;

[0040] Figure 2 is a schematic diagram of the generator in Embodiment 2 of the present invention;

[0041] Figure 3 is a schematic diagram of the generator in Embodiment 3 of the present invention;

[0042] Figure 4 is a flowchart of Embodiment 4 of the present invention.

[0043] 1-Mother liquor tank; 2-Eluting tank; 3-First elution tank; 4-Second elution tank; 5-First six-way valve; 6-Second six-way valve; 7-Third six-way valve; 8-First separation column; 9-First injection pump; 10-Second injection pump; 11-Evaporating dish; 12-Baffle; 13-Small hole; 14-Inlet pipe; 15-Outlet; 16-Heating device; 17-Second separation column; 18-Third separation column. Detailed Implementation

[0044] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0045] Strontium-containing mother liquor tank 90 See Table 1 for the quality standards of the mother liquor (Sr).

[0046] Table 1 Quality Standards

[0047] Example 1

[0048] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The generator of Y] includes a mother liquor tank 1, a rinsing tank 2, a first elution tank 3, a second elution tank 4, an automatic separation device, an evaporation recovery device, and a control unit;

[0049] Referring to Figure 1, the automatic separation device includes a first separation column 8, a connecting device, a first injection pump 9, and a second injection pump 10. The connecting device includes a first six-way valve 5, a second six-way valve 6, and a third six-way valve 7. The resin in the first separation column 8 is CL-P204 extraction resin. The mother liquor tank 1 is used to supply strontium-containing […] to the first separation column 8. 90 Sr] mother liquor, and then using the first separation column 8 to separate strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 [Y] is adsorbed, and the first injection pump 9 is used to draw eluent from the eluent tank 2 to eluent the first separation column 8. The strontium adsorbed on the first separation column 8 is eluented. 90 Sr], in solution form, is fed into the evaporation recovery unit. The second injection pump 10 is used to draw eluent from the first elution tank 3 to elute the first separation column 8. The yttrium adsorbed on the first separation column 8 is eluted. 90 Y] is fed into the second elution tank 4 in the form of a solution.

[0050] The first six-way valve 5, the second six-way valve 6, and the third six-way valve 7 are used to selectively connect the mother liquor tank 1, the rinsing tank 2, the first elution tank 3, the second elution tank 4, the first separation column 8, the first injection pump 9, and the second injection pump 10. Specifically, the common port C of the first six-way valve 5 is connected to the inlet of the first separation column 8, port 1# is connected to port 1# of the second six-way valve 6, port 2# is connected to the first elution tank 3 through the second injection pump 10, and port 3# is connected to port 3# of the second six-way valve 6. The system has the following connections: Port 4# connects to the first injection pump 8 and the rinsing tank 2; Port 5# connects to air; Port 6# connects to Port 4# of the second six-way valve 6; Port 2# of the second six-way valve 6 connects to the mother liquor tank 1; and the common port C connects to the inlet of the first separation column 8. The common port C of the third six-way valve 7 connects to the outlet of the first separation column 8; Port 1# of the third six-way valve 7 connects to the inlet pipe 14 of the evaporation recovery device; and Port 2# of the third six-way valve 7 connects to the second elution tank 4. The central holes of the first six-way valve 5, the second six-way valve 6, and the third six-way valve 7 form a common channel, allowing for multi-channel switching by the rotor to achieve alternating passage of different solutions. The flow channel diameter is 1.2 mm, the port-to-port volume is 27.5 μL, the rotor groove volume is 5.41 μL, the liquid contact material is PCTEF or sapphire, the pipe interface is a 1 / 4-28 UNF threaded interface, the switching time is less than 4 seconds per revolution, and the maximum driving force is 4 N / m. The design accuracy error of the first and second injection pumps is less than 1%, and the repeatability error is 0.3%-0.5%. Different sizes of syringes, from 50μL to 10mL, can be selected according to actual usage. The tubing interface is a 1 / 4-28UNF threaded interface, and the rated stroke running time is 2s-12000s (pure water medium). The control unit controls the hardware including the first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10. The hardware used includes a 485 hub and a miniature touchscreen. The first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10 communicate through the 485 hub and the miniature touchscreen. The host computer software sends control commands to the 485 hub using the computer's serial port, and the hub then distributes the commands to each device, thereby achieving control of the hardware. The sealing material for the top cover of the first separation column 8 is thermoplastic polyurethane elastomer rubber, and the middle thread is made of polyetheretherketone (PEEK).

[0051] The evaporation recovery device includes an inlet pipe 14, an evaporating dish 11, a baffle 12, an outlet 15, and a heating device 16; the baffle 12 is located inside the evaporating dish 11 and is used to prevent strontium from […]. 90The strontium [Sr] solution splashes during evaporation, and the baffle 12 has small holes 13 for venting the gas after evaporation; the inlet pipe 14 is installed through the baffle 12, with one end connected to the connecting device and the rinsing tank 2, and the other end suspended above the bottom of the evaporating dish 11; the outlet 15 is located on one side of the outer surface of the evaporating dish 11 and is connected to the mother liquor tank 1; the heating device 16 is located at the bottom of the evaporating dish 11 for heating the strontium [Sr] solution inside the evaporating dish 11. 90 The Sr solution was heated.

[0052] The control unit is connected to the first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10 via signal connection.

[0053] Example 2

[0054] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The generator of Y] includes a mother liquor tank 1, a rinsing tank 2, a first elution tank 3, a second elution tank 4, an automatic separation device, an evaporation recovery device, a second separation column 17, and a control unit;

[0055] Referring to Figure 1, the automatic separation device includes a first separation column 8, a connecting device, a first injection pump 9, and a second injection pump 10. The connecting device includes a first six-way valve 5, a second six-way valve 6, and a third six-way valve 7. The resin in the first separation column 8 is CL-P204 extraction resin. The mother liquor tank 1 is used to supply strontium-containing […] to the first separation column 8. 90 Sr] mother liquor, and then using the first separation column 8 to separate strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 [Y] is adsorbed, and the first injection pump 9 is used to draw eluent from the eluent tank 2 to eluent the first separation column 8. The strontium adsorbed on the first separation column 8 is eluented. 90 Sr], in solution form, is fed into the evaporation recovery unit. The second injection pump 10 is used to draw eluent from the first elution tank 3 to elute the first separation column 8. The yttrium adsorbed on the first separation column 8 is eluted. 90 Y] is fed into the second elution tank 4 in the form of a solution.

[0056] The first six-way valve 5, the second six-way valve 6, and the third six-way valve 7 are used to selectively connect the mother liquor tank 1, the rinsing tank 2, the first elution tank 3, the second elution tank 4, the first separation column 8, the first injection pump 9, and the second injection pump 10. Specifically, the common port C of the first six-way valve 5 is connected to the inlet of the first separation column 8, port 1# is connected to port 1# of the second six-way valve 6, port 2# is connected to the first elution tank 3 through the second injection pump 10, and port 3# is connected to port 3# of the second six-way valve 6. The system is as follows: Port 4# is connected to the first injection pump 8 and the rinsing tank 2; Port 5# is connected to air; Port 6# is connected to Port 4# of the second six-way valve 6; Port 2# of the second six-way valve 6 is connected to the mother liquor tank 1; and the common end C port is connected to the inlet of the first separation column 8. The common end C port of the third six-way valve 7 is connected to the outlet of the first separation column 8; Port 1# of the third six-way valve 7 is connected to the inlet pipe 14 of the evaporation recovery device; and Port 2# of the third six-way valve 7 is connected to the inlet of the second separation column 17. The central holes of the first six-way valve 5, the second six-way valve 6, and the third six-way valve 7 form a common channel, allowing for multi-channel switching by the rotor to achieve alternating passage of different solutions. The flow channel diameter is 1.2 mm, the port-to-port volume is 27.5 μL, the rotor groove volume is 5.41 μL, the liquid contact material is PCTEF or sapphire, the pipe interface is a 1 / 4-28 UNF threaded interface, the switching time is less than 4 seconds per revolution, and the maximum driving force is 4 N / m. The design accuracy error of the first and second injection pumps is less than 1%, and the repeatability error is 0.3%-0.5%. Different sizes of syringes, from 50μL to 10mL, can be selected according to actual usage. The tubing interface is a 1 / 4-28UNF threaded interface, and the rated stroke running time is 2s-12000s (pure water medium). The control unit controls the hardware including the first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10. The hardware used includes a 485 hub and a miniature touchscreen. The first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10 communicate through the 485 hub and the miniature touchscreen. The host computer software sends control commands to the 485 hub using the computer's serial port, and the hub then distributes the commands to each device, thereby achieving control of the hardware. The sealing material for the top cover of the first separation column 8 is thermoplastic polyurethane elastomer rubber, and the middle thread is made of polyetheretherketone (PEEK).

[0057] The evaporation recovery device includes an inlet pipe 14, an evaporating dish 11, a baffle 12, an outlet 15, and a heating device 16; the baffle 12 is located inside the evaporating dish 11 and is used to prevent strontium from […]. 90The strontium [Sr] solution splashes during evaporation, and the baffle 12 has small holes 13 for venting the gas after evaporation; the inlet pipe 14 is installed through the baffle 12, with one end connected to the connecting device and the rinsing tank 2, and the other end suspended above the bottom of the evaporating dish 11; the outlet 15 is located on one side of the outer surface of the evaporating dish 11 and is connected to the mother liquor tank 1; the heating device 16 is located at the bottom of the evaporating dish 11 for heating the strontium [Sr] solution inside the evaporating dish 11. 90 The Sr solution was heated.

[0058] The control unit is connected to the first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10 via signal connection.

[0059] The inlet of the second separation column 17 is connected to the first elution tank 3 and port #2 of the third six-way valve 5, and the outlet is connected to the second elution tank 4. The resin of the second separation column 17 is CL-P204 extraction resin.

[0060] Example 3

[0061] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The generator of Y] includes a mother liquor tank 1, a rinsing tank 2, a first elution tank 3, a second elution tank 4, an automatic separation device, an evaporation recovery device, a second separation column 17, a third separation column 18, and a control unit;

[0062] Referring to Figure 1, the automatic separation device includes a first separation column 8, a connecting device, a first injection pump 9, and a second injection pump 10. The connecting device includes a first six-way valve 5, a second six-way valve 6, and a third six-way valve 7. The resin in the first separation column 8 is CL-P204 extraction resin. The mother liquor tank 1 is used to supply strontium-containing […] to the first separation column 8. 90 Sr] mother liquor, and then using the first separation column 8 to separate strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 [Y] is adsorbed, and the first injection pump 9 is used to draw eluent from the eluent tank 2 to eluent the first separation column 8. The strontium adsorbed on the first separation column 8 is eluented. 90 Sr], in solution form, is fed into the evaporation recovery unit. The second injection pump 10 is used to draw eluent from the first elution tank 3 to elute the first separation column 8. The yttrium adsorbed on the first separation column 8 is eluted. 90 Y] is fed into the second elution tank 4 in the form of a solution.

[0063] The first six-way valve 5, the second six-way valve 6, and the third six-way valve 7 are used to selectively connect the mother liquor tank 1, the rinsing tank 2, the first elution tank 3, the second elution tank 4, the first separation column 8, the first injection pump 9, and the second injection pump 10. Specifically, the common port C of the first six-way valve 5 is connected to the inlet of the first separation column 8, port 1# is connected to port 1# of the second six-way valve 6, port 2# is connected to the first elution tank 3 through the second injection pump 10, and port 3# is connected to port 3# of the second six-way valve 6. The system is as follows: Port 4# is connected to the first injection pump 8 and the rinsing tank 2; Port 5# is connected to air; Port 6# is connected to Port 4# of the second six-way valve 6; Port 2# of the second six-way valve 6 is connected to the mother liquor tank 1; and the common end C port is connected to the inlet of the first separation column 8. The common end C port of the third six-way valve 7 is connected to the outlet of the first separation column 8; Port 1# of the third six-way valve 7 is connected to the inlet pipe 14 of the evaporation recovery device; and Port 2# of the third six-way valve 7 is connected to the inlet of the second separation column 17. The central holes of the first six-way valve 5, the second six-way valve 6, and the third six-way valve 7 form a common channel, allowing for multi-channel switching by the rotor to achieve alternating passage of different solutions. The flow channel diameter is 1.2 mm, the port-to-port volume is 27.5 μL, the rotor groove volume is 5.41 μL, the liquid contact material is PCTEF or sapphire, the pipe interface is a 1 / 4-28 UNF threaded interface, the switching time is less than 4 seconds per revolution, and the maximum driving force is 4 N / m. The design accuracy error of the first and second injection pumps is less than 1%, and the repeatability error is 0.3%-0.5%. Different sizes of syringes, from 50μL to 10mL, can be selected according to actual usage. The tubing interface is a 1 / 4-28UNF threaded interface, and the rated stroke running time is 2s-12000s (pure water medium). The control unit controls the hardware including the first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10. The hardware used includes a 485 hub and a miniature touchscreen. The first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10 communicate through the 485 hub and the miniature touchscreen. The host computer software sends control commands to the 485 hub using the computer's serial port, and the hub then distributes the commands to each device, thereby achieving control of the hardware. The sealing material for the top cover of the first separation column 8 is thermoplastic polyurethane elastomer rubber, and the middle thread is made of polyetheretherketone (PEEK).

[0064] The evaporation recovery device includes an inlet pipe 14, an evaporating dish 11, a baffle 12, an outlet 15, and a heating device 16; the baffle 12 is located inside the evaporating dish 11 and is used to prevent strontium from […]. 90The strontium [Sr] solution splashes during evaporation, and the baffle 12 has small holes 13 for venting the gas after evaporation; the inlet pipe 14 is installed through the baffle 12, with one end connected to the connecting device and the rinsing tank 2, and the other end suspended above the bottom of the evaporating dish 11; the outlet 15 is located on one side of the outer surface of the evaporating dish 11 and is connected to the mother liquor tank 1; the heating device 16 is located at the bottom of the evaporating dish 11 for heating the strontium [Sr] solution inside the evaporating dish 11. 90 The Sr solution was heated.

[0065] The control unit is connected to the first six-way valve 5, the second six-way valve 6, the third six-way valve 7, the first injection pump 9, and the second injection pump 10 via signal connection.

[0066] The inlet of the second separation column 17 is connected to the first eluent tank 3 and port #2 of the 3 / 6-way valve 6, and the outlet is connected to the inlet of the third separation column 18. The resin of the second separation column 17 is CL-P204 extraction resin.

[0067] The inlet of the third separation column 18 is connected to the outlet of the first elution tank 3 and the second separation column 17, and the outlet is connected to the second elution tank 4. The resin of the third separation column 18 is CL-P204 extraction resin.

[0068] Example 4

[0069] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in [Y] uses the generator of Example 1, with a resin separation column volume of 1 mL, and the second to third mL of the eluent is used as the product solution.

[0070] Specifically, the following steps are included:

[0071] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (CL-P204 extraction resin, pore size 40-150 mesh, purchased from Zhengzhou Aino Chemical Technology Co., Ltd.) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0072] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0073] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery device through the common port C and port 1 of the third six-way valve.

[0074] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to dissolve the solid completely. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0075] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90[Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0076] Example 5

[0077] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 2 uses the generator described in Example 2. The volume of the resin separation column is 1 mL, and the second to third mL of the eluent is used as the product solution.

[0078] Specifically, the following steps are included:

[0079] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (CL-P204 extraction resin, pore size 40-150 mesh) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0080] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0081] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0082] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0083] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second separation column through the common port C and port 2# of the third six-way valve.

[0084] S6: Pass the product solution eluted from the first separation column through the separation resin (CL-P204 extraction resin, pore size 40-150 mesh) in the second separation column at a rate of 1 mL / min. Take an 8 mol / L hydrochloric acid solution from the first elution tank and pass it through the separation resin in the second separation column. Collect the purified yttrium-containing solution through the second elution tank. 90 The eluent of Y]. Yttrium in the second eluent tank. 90 The solution containing yttrium [Y] is the collected solution.90 The elution buffer of Y].

[0085] Example 6

[0086] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 3 uses the generator described in Example 3. The volume of the resin separation column is 1 mL, and the second to third mL of the eluent is used as the product solution.

[0087] Specifically, the following steps are included:

[0088] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (CL-P204 extraction resin) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0089] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0090] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0091] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0092] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second separation column through the common port C and port 2# of the third six-way valve.

[0093] S6: The product liquid eluted from the first separation column is passed through the separation resin (CL-P204 extraction resin, pore size 40-150 mesh) in the second separation column at a rate of 1 mL / min. An 8 mol / L hydrochloric acid solution is drawn from the first elution tank, passed through the separation resin in the second separation column, and then enters the third separation column.

[0094] S7: Pass the product solution eluted from the second separation column through the separation resin (CL-P204 extraction resin, pore size 40-150 mesh) in the third separation column at a rate of 1 mL / min. Take an 8 mol / L hydrochloric acid solution from the first elution tank and pass it through the separation resin in the third separation column. Collect the purified yttrium-containing solution through the second elution tank. 90 The eluent of Y]. Yttrium in the second eluent tank. 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0095] Example 7

[0096] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in [Y] uses the generator of Example 1, with a resin separation column volume of 1 mL, and the second to third mL of the eluent is used as the product solution.

[0097] Specifically, the following steps are included:

[0098] S1: 2 mL of 1.5 mol / L nitric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (CL-P204 extraction resin, pore size 40-150 mesh, purchased from Zhengzhou Aino Chemical Technology Co., Ltd.) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0099] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0100] S3: 11 mL of 1.5 mol / L nitric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then flows at a rate of 1 mL / min through the common port C of the second six-way valve into the separation resin of the first separation column, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery device through the common port C and port 1 of the third six-way valve.

[0101] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1.5 mol / L nitric acid solution drawn from the eluent tank was added to dissolve the solid completely. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0102] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, and then draw 3 mL of 6 mol / L nitric acid solution from the second eluent tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0103] Comparative Example 1

[0104] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in [Y] uses the generator of Example 1, with a resin separation column volume of 1 mL, and the second to third mL of the eluent is used as the product solution.

[0105] Specifically, the following steps are included:

[0106] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (cation exchange resin, pore size 0.5-1.0 mm, purchased from Langfang Senate Chemical Co., Ltd., model SNT-D001) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0107] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0108] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0109] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0110] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0111] Comparative Example 2

[0112] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in [Y] uses the generator of Example 1, with a resin separation column volume of 1 mL, and the second to third mL of the eluent is used as the product solution.

[0113] Specifically, the following steps are included:

[0114] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (SR resin, pore size 40-150 mesh, purchased from Zhejiang Zhengguang Industrial Co., Ltd., model SR-1) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0115] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0116] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0117] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0118] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0119] Comparative Example 3

[0120] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in [Y] uses the generator of Example 1, with a resin separation column volume of 1 mL, and the second to third mL of the eluent is used as the product solution.

[0121] Specifically, the following steps are included:

[0122] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (HDEHP extraction resin, pore size 40-120 mesh, purchased from Beijing Zhengguang Venture Technology Co., Ltd., model ZGCLP204) of the first separation column through the common port C of the first six-way valve. The separation resin is then equilibrated for 5 minutes.

[0123] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0124] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0125] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0126] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0127] Comparative Example 4

[0128] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in [Y] uses the generator of Example 1, with a resin separation column volume of 1 mL, and the second to third mL of the eluent is used as the product solution.

[0129] Specifically, the following steps are included:

[0130] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4# of the first six-way valve. The solution is then introduced into the separation resin (strontium-specific crown ether resin, with a pore size of 40-120 mesh, produced by Trisem International, France, and prepared by attaching 4,4'-(5')-bis(tetra-butylcyclohexyl)-18-crown-6 to an inert monomer) of the first separation column through the common port C of the first six-way valve. The separation resin is then equilibrated for 5 min.

[0131] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0132] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0133] S4: Strontium-containing materials collected in steps S2 and S3 90The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0134] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0135] Comparative Example 5

[0136] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in [Y] uses the generator of Example 1, with a resin separation column volume of 1 mL, and the second to third mL of the eluent is used as the product solution.

[0137] Specifically, the following steps are included:

[0138] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (CL-P204 extraction resin, pore size 40-150 mesh) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0139] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0140] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0141] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0142] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0143] Comparative Example 6

[0144] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in [Y] uses the generator of Example 1, with a resin separation column volume of 1 mL, and the second to third mL of the eluent is used as the product solution.

[0145] Specifically, the following steps are included:

[0146] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (CL-P204 extraction resin, pore size 40-150 mesh) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0147] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0148] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0149] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0150] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0151] Comparative Example 7

[0152] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Y] is implemented using the generator of Example 1, but in the generator, the evaporation recovery device does not include a baffle, the volume of the resin separation column is 1 mL, and the 2nd-3rd mL of the eluent is used as the product liquid.

[0153] Specifically, the following steps are included:

[0154] S1: 2 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through the first injection pump from port 4 of the first six-way valve and introduced into the separation resin (CL-P204 extraction resin, pore size 40-150 mesh) of the first separation column through the common port C of the first six-way valve to equilibrate the separation resin for 5 min.

[0155] S2: Draw 2 mL of yttrium-containing solution from port 2 of the second six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] mother liquor, switch the second six-way valve to port 1#, switch the first six-way valve to port 1#, so that the yttrium-containing [ 90 Strontium of Y] 90 The mother liquor [Sr] enters the first six-way valve through port 1# of the second six-way valve, and then enters the separation resin of the first separation column through the common port C of the first six-way valve at a rate of 1 mL / min, causing a large amount of yttrium [ 90 Y] and very small amounts of strontium[ 90 Sr] adheres to the separating resin, and the third six-way valve is switched to port 1, allowing the resin containing a large amount of strontium [ 90 Sr] and very small amounts of yttrium[ 90 The solution enters the third six-way valve through the common port C of the third six-way valve and then from port 1# into the inlet pipe of the evaporation and recovery device.

[0156] S3: 11 mL of 1 mol / L hydrochloric acid solution is drawn from the rinsing tank through port 4 of the first six-way valve using the first injection pump. The first six-way valve is switched to port 6, and the second six-way valve is switched to port 4, allowing the rinsing solution to pass through port 6 of the first six-way valve and into port 4 of the second six-way valve. This solution then enters the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the very small amount of strontium adhering to the separation resin. 90 Sr] is rinsed, and the third six-way valve is switched to port 1, so that the strontium content is very low. 90 The Sr solution enters the inlet pipe of the evaporation and recovery unit through the common port C and port 1 of the third six-way valve.

[0157] S4: Strontium-containing materials collected in steps S2 and S3 90 The eluent of Sr] was slowly introduced into the evaporating dish at a rate of 1 mL / min through the inlet pipe of the evaporation recovery device. Evaporation was carried out at 90°C, and the evaporated gas was discharged through small holes in the baffle. After the solution was completely evaporated, 1 mol / L hydrochloric acid solution was added from the eluent tank to completely dissolve the solid. After standing for 10 days, […]. 90 Sr]-Yttrium[ 90 Y] Rinse solution, and add it to the mother liquor tank for recycling.

[0158] S5: Switch the port of the first six-way valve to port 5#, use air to purge the liquid in the first separation column, then draw 3 mL of 8 mol / L hydrochloric acid solution from the second elution tank through port 2# of the first six-way valve using the second syringe pump. Switch both the first and second six-way valves to port 3#, allowing the eluent to pass through port 3# of the first six-way valve and into port 3# of the second six-way valve, and then enter the separation resin of the first separation column at a rate of 1 mL / min through the common port C of the second six-way valve, thus removing the large amount of yttrium adhering to the separation resin. 90 [Y] is used for elution, and the third six-way valve is switched to port 2#, so that the yttrium [ 90 The Y] solution enters the second elution tank through the common port C and port 2# of the third six-way valve. The yttrium [ 90 The solution containing yttrium [Y] is the collected solution. 90 The elution buffer of Y].

[0159] Experimental Example

[0160] The strontium content in the eluent was determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). The formula is: Strontium recovery rate = 1 - (Strontium in the eluent) / (Strontium in the eluent) 90 Sr] content / Strontium in strontium mother liquor 90 The Sr content was calculated to obtain the Sr content of Examples 4-7 and Comparative Examples 1-6. 90 Sr] recovery rate, Strontium[ 90 The detection results of Sr and Strontium 90 The recovery rate of Sr is shown in Table 2.

[0161] Table 2 Strontium [ 90 Detection results of Sr] content and Strontium [ 90 Recovery rate of Sr]

[0162] Yttrium in the eluent was detected by inductively coupled plasma atomic emission spectrometry. 90The radiochemical activity of Y, and the yttrium in the eluents of Examples 4-6 and Comparative Examples 1-6. 90 The radiochemical activity results of Y are shown in Table 3.

[0163] Table 3. Yttrium in the eluent [ 90 Radiochemical activity of Y]

[0164] Conclusion: By comparing the data from Examples 4-6, it can be seen that by focusing on yttrium-containing [ 90 The eluent of Y can be purified multiple times to reduce the yttrium content. 90 Strontium in the eluent of Y] 90 Sr]-Yttrium[ 90 The radioactivity of yttrium [γ]. By comparing the data from Example 4 and Comparative Examples 1-4, it can be seen that selecting CL-P204 extraction resin as the separation resin for the first separation column can reduce the radioactivity of yttrium [γ]. 90 Y] is completely adsorbed in the resin, while strontium[ 90 Sr] flows out directly, through the yttrium [ 90 Eluting with Y can reduce strontium [ 90 Sr]-Yttrium[ 90 The radioactivity of strontium [γ]. By comparing the data from Example 4 and Comparative Examples 5-6, it can be seen that when the evaporation temperature is higher than 95°C, it will lead to the radioactivity of strontium [γ]. 90 The reduced recovery rate of Sr is due to boiling explosion during evaporation, which reduces the recovery rate of Sr. 90 Sr] will generate aerosols with the steam, leading to the formation of strontium[ 90 Sr] loss can also occur when the evaporation temperature is below 85℃. 90 The reduced recovery rate of Sr is due to the excessively low evaporation temperature, resulting in lower strontium recovery after evaporation. 90 Sr crystals adhere to the surface of the evaporation dish, causing strontium [ 90 Sr] Loss.

[0165] Although the principles of the present invention have been described in detail above with reference to preferred embodiments, those skilled in the art should understand that the above embodiments are merely illustrative explanations of the implementation of the present invention and are not intended to limit the scope of the present invention. The details in the embodiments do not constitute a limitation on the scope of the present invention. Any obvious changes, such as equivalent transformations or simple substitutions, based on the technical solutions of the present invention without departing from the spirit and scope of the present invention fall within the protection scope of the present invention.

Claims

1. A method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, Includes the following steps: S1: To make strontium-containing [ 90 The mother liquor was passed through a resin separation column to separate the yttrium [Sr] from the mother liquor. 90 [Y] is adsorbed, and the strontium on the resin separation column is removed using the eluent. 90 Sr was rinsed to collect strontium-containing [ 90 The eluent of Sr] is then purged from the resin separation column with air; S2: For strontium-containing [ 90 The eluent of Sr was evaporated at 85-95℃ to obtain strontium [ 90 The crystals of Sr were dissolved using a leaching solution, and after standing for 8-12 days, the leaching solution was collected and added to a strontium-containing […]. 90 Sr] is circulated in the mother liquor; S3: Use eluent to remove yttrium from the resin separation column. 90 Y] was eluted to collect yttrium-containing [ 90 The elution buffer of Y]; Among them, the yttrium-containing [ 90 In the eluent of Y], strontium[ 90 Sr]-Yttrium[ 90 The radioactivity ratio of Y] is less than 10. -6 .

2. The method for separating strontium-containing [[] according to claim 1] 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, Also includes: For yttrium-containing [ 90 The eluent of Y] is then adsorbed using at least one set of resin separation columns. The resin separation columns are eluted with the eluent, and the purified yttrium-containing [Y] is collected. 90 The elution buffer of Y].

3. The method for separating strontium-containing [[] according to claim 2] 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, For yttrium-containing [ 90 The eluent of Y] was then adsorbed onto a set of resin separation columns. The resin separation columns were eluted with the eluent, and the purified yttrium-containing [Y] was obtained. 90 In the eluent of Y], strontium[ 90 Sr]-Yttrium[ 90 The radioactivity ratio of Y] is less than 10. -7 .

4. The method for separating strontium-containing [[] according to claim 2] 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, For yttrium-containing [ 90 The eluent of Y] was then adsorbed onto two sets of resin separation columns. The resin separation columns were eluted with the eluent, and the purified yttrium-containing [Y] was obtained. 90 In the eluent of Y], strontium[ 90 Sr]-Yttrium[ 90 The radioactivity ratio of Y] is less than 10. -8 .

5. The method for separating strontium-containing [[] according to claim 1] 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, The total volume of the eluent used is at least 11 times the volume of the resin separation column; The rinsing rate is 0.25-1 mL / min; The concentration of the eluent is 1 mol / L, and the eluent is selected from nitric acid, sulfuric acid or hydrochloric acid; The concentration of the eluent is 8 mol / L, and the eluent is selected from nitric acid, sulfuric acid or hydrochloric acid.

6. A method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The generator of Y] is characterized in that, It includes a mother liquor tank, a rinsing tank, a first elution tank, a second elution tank, an automatic separation device, and an evaporation recovery device. The automatic separation device includes a first separation column, a connecting device, a first injection pump, and a second injection pump. The connecting device is used to selectively connect the mother liquor tank, rinsing tank, first elution tank, second elution tank, first separation column, first injection pump, and second injection pump. The mother liquor tank is used to supply strontium-containing [[ 90 Sr] mother liquor, and then the first separation column is used to separate the strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 Y] is adsorbed; The first injection pump is used to draw eluent from the eluent tank to eluent the first separation column, and the strontium adsorbed on the first separation column is eluented. 90 Sr] is fed into the evaporation and recovery device in the form of a solution; The second injection pump is used to draw eluent from the first elution tank to elute the first separation column, eluting the yttrium adsorbed on the first separation column. 90 Y] is fed into the second elution tank in the form of a solution; The resin used in the first separation column is CL-P204 elution resin with a pore size of 40-150 mesh.

7. The method for separating strontium-containing compounds according to claim 6 90 Yttrium in mother liquor (Sr) 90 The generator of Y] is characterized in that, The evaporation recovery device includes an inlet pipe, an evaporating dish, a baffle, an outlet, and a heating device; The baffle is located inside the evaporating dish to prevent strontium [ 90 The Sr solution splashes during the evaporation process, and the baffle is provided with small holes for the gas to be discharged after evaporation; The liquid inlet pipe is installed through the baffle, with one end connected to the connecting device and the rinsing tank, and the other end suspended above the bottom of the evaporating dish; The liquid outlet is located on one side of the outer surface of the evaporating dish and is connected to the mother liquor tank; The heating device is located at the bottom of the evaporating dish and is used to heat the strontium [[] in the evaporating dish. 90 The Sr solution was heated.

8. The method for separating strontium-containing compounds according to claim 1 90 Yttrium in mother liquor (Sr) 90 The generator of Y] is characterized in that, The connecting device includes a first six-way valve, a second six-way valve, and a third six-way valve; The common port C of the first six-way valve is connected to the inlet of the first separation column, port 1 is connected to port 1 of the second six-way valve, port 2 is connected to the first elution tank through the second injection pump, port 3 is connected to port 3 of the second six-way valve, port 4 is connected to the rinsing tank through the first injection pump, port 5 is connected to air, and port 6 is connected to port 4 of the second six-way valve. The second six-way valve's #2 port is connected to the mother liquor tank, and its common port C is connected to the inlet of the first separation column; The common port C of the third six-way valve is connected to the liquid outlet of the first separation column, the 1# port of the third six-way valve is connected to the liquid inlet pipe of the evaporation recovery device, and the 2# port of the third six-way valve is connected to the second elution tank.

9. The method for separating strontium-containing compounds according to claim 1 90 Yttrium in mother liquor (Sr) 90 The generator of Y] is characterized in that, The generator further includes at least one set of separation columns for eluting yttrium [from the first separation column]. 90 The Y] solution is eluted again; the inlet of each separation column is connected to the first elution tank; At least one set of separation columns uses CL-P204 extraction resin.

10. The method for separating strontium-containing compounds according to claim 1 90 Yttrium in mother liquor (Sr) 90 The generator of Y] is characterized in that, The generator also includes a control unit; The control unit is signal-connected to the communication device, the first injection pump, and the second injection pump; The contact material of the connecting device is selected from either polychlorotrifluoroethylene or sapphire. The evaporating dish is made of polyetheretherketone (PEEK); The accuracy error of the liquid volume of the first injection pump and the second injection pump is less than 1%.

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