Reaction device and compound production method

Abstract

The present invention provides a reaction device with which it is possible to improve the quality of a post-reaction liquid while preventing or inhibiting clogging in a flow path, and also provides a compound production method. This reaction device comprises: a flow path in which a pre-reaction liquid flows down a first portion of the flow path and in a second portion of the flow path, the pre-reaction liquid undergoes a reaction such that a post-reaction liquid is produced; a detection unit which has a detection element for detecting a clog or a sign of a clog in the flow path; and a clog-clearing means for clearing or reducing the clog or the sign of a clog.

Description

Reaction apparatus and method for producing compounds

[0001] Some aspects of the present invention relate to a reaction apparatus and a method for producing compounds.

[0002] For example, as shown in Patent Document 1, there is a known apparatus for producing a reaction solution by mixing and reacting two liquids. The apparatus described in Patent Document 1 has two flow channels, a reactor as a confluence section that brings the flow channels together, and a vibration device that applies ultrasonic vibrations to the reactor.

[0003] By applying ultrasonic vibrations to the reactor, reaction products adhering to the inner wall of the reactor can be removed, thereby preventing or suppressing clogging in the reactor.

[0004] However, depending on the type of reaction between the two liquids, there is a concern that applying ultrasonic vibrations may activate the reaction, leading to the creation of multiple reaction initiations and a decrease in molecular weight dispersion. In other words, there is a risk that the quality of the reaction solution may deteriorate due to the application of ultrasonic vibrations. Conventionally, this point has not been sufficiently considered.

[0005] Japanese Patent Publication No. 2004-337649

[0006] Objects of some aspects of the present invention are to provide a reaction apparatus and a method for producing a compound that can improve the quality of the post-reaction liquid while preventing or suppressing clogging of the flow path.

[0007] A reaction apparatus according to some embodiments of the present invention is characterized by comprising: a flow path through which a pre-reaction liquid flows down a first portion of the flow path and through which the pre-reaction liquid reacts to produce a post-reaction liquid in a second portion of the flow path; a detection unit having a detection element for detecting blockage or signs of blockage in the flow path; and a blockage removal means for eliminating or mitigating the blockage or signs of blockage.

[0008] In a reaction apparatus according to some embodiments of the present invention, if the detection unit detects the blockage or signs of the blockage, it is preferable that the detection unit transmits a signal indicating the blockage or signs of the blockage directly or indirectly to the blockage clearing means.

[0009] In a reaction apparatus according to some embodiments of the present invention, it is preferable that the apparatus further comprises a control unit, the control unit transmits a first signal to the detection unit to perform detection of the blockage or signs of blockage, the control unit receives a second signal indicating the blockage or signs of blockage when the detection unit detects the blockage or signs of blockage, and the control unit transmits a third signal to the blockage clearing means to perform clearing or mitigating the blockage or signs of blockage when the second signal is received.

[0010] In a reaction apparatus according to some embodiments of the present invention, the flow path comprises a first flow path through which a first liquid as a pre-reaction liquid flows, a second flow path through which a second liquid that reacts with the first liquid flows, a confluence where the first and second flow paths merge, and a third flow path connected to the first and second flow paths via the confluence, through which a mixture of the first and second liquids flows, wherein the detection element is preferably provided in at least one of the first flow path, the second flow path, the confluence, and the third flow path.

[0011] In a reaction apparatus according to some embodiments of the present invention, a catalyst is provided in the flow path to react with the pre-reaction liquid flowing down the flow path, and the detection element is preferably provided in at least one of the first portion of the flow path upstream of the catalyst and the second portion downstream of the catalyst.

[0012] In reaction apparatuses according to some embodiments of the present invention, the detection element is preferably an acoustic sensor.

[0013] In a reaction apparatus according to some embodiments of the present invention, the detection element is preferably an optical sensor.

[0014] In a reaction apparatus according to some embodiments of the present invention, the detection element is preferably one of the flow sensors.

[0015] In a reaction apparatus according to some embodiments of the present invention, the clogging removal means preferably has a vibration applying unit that applies ultrasonic vibration to the part of the flow path that is clogged or shows signs of clogging.

[0016] In a reaction apparatus according to some embodiments of the present invention, the declogging means further comprises a storage tank for storing liquid, at least a portion of the flow path is immersed in the liquid, and the vibration applying unit preferably applies the ultrasonic vibration to at least a portion of the flow path via the liquid.

[0017] In some embodiments of the present invention, it is preferable to have a reaction apparatus that includes multiple pairs of the flow path and the detection element.

[0018] A method for producing a compound according to some embodiments of the present invention is characterized by comprising: a reaction step of flowing a pre-reaction liquid down a channel and reacting it in at least a portion of the channel to produce a post-reaction liquid; a detection step of detecting a blockage or signs of blockage in at least a portion of the channel before and after the reaction step; and a blockage removal step of eliminating or mitigating the blockage or signs of blockage if the blockage or signs of blockage are detected in the detection step.

[0019] In a method for producing a compound according to some embodiments of the present invention, it is preferable to have a cleaning step after the blockage removal step in which at least a portion of the flow path is cleaned.

[0020] In a method for producing a compound according to some embodiments of the present invention, the pre-reaction liquid is a first liquid, and in the reaction step, it is preferable to allow the first liquid to flow down the first channel of the flow path, allow the second liquid to react with the first liquid to flow down the second channel, and mix the first liquid and the second liquid at the confluence of the first channel and the second channel.

[0021] In a method for producing a compound according to some embodiments of the present invention, the first liquid preferably contains a first substance, and the first substance preferably contains at least one metal element.

[0022] In the method for producing a compound according to an application example of some aspects of the present invention, the second liquid contains a second substance, and the second substance is preferably a polymerizable substance.

[0023] In the method for producing a compound according to an application example of some aspects of the present invention, it is preferable that a living polymerization reaction occurs by mixing the first liquid and the second liquid.

[0024] In the method for producing a compound according to an application example of some aspects of the present invention, a polymer of the second substance is obtained by the living polymerization reaction, and the molecular weight distribution of the polymer is preferably 1.2 or less.

[0025] According to the present invention, it is possible to provide a reaction apparatus and a method for producing a compound that can improve the quality of the liquid after the reaction while preventing or suppressing clogging of the flow path.

[0026] FIG. 1 is a schematic diagram showing a reaction apparatus according to a first embodiment of the present invention. FIG. 2 is a block diagram of the reaction apparatus shown in FIG. 1. FIG. 3 is a cross-sectional view showing an example of the detection unit shown in FIG. 1. FIG. 4 is a cross-sectional view showing an example of the detection unit shown in FIG. 1. FIG. 5 is a cross-sectional view showing an example of the detection unit shown in FIG. 1. FIG. 6 is a schematic diagram showing a reaction apparatus according to a second embodiment of the present invention. FIG. 7 is a schematic diagram (cross-sectional view) showing a reaction apparatus according to a third embodiment of the present invention.

[0027] Hereinafter, a reaction apparatus, a method for producing a compound, and the like will be described in detail based on embodiments according to some aspects of the present invention with reference to the accompanying drawings.

[0028] <First Embodiment> FIG. 1 is a schematic diagram showing a reaction apparatus according to a first embodiment of the present invention. FIG. 2 is a block diagram of the reaction apparatus shown in FIG. 1. FIGS. 3 to 5 are cross-sectional views showing an example of the detection unit shown in FIG. 1.

[0029] [1] Reaction Apparatus The reaction apparatus 100 shown in FIGS. 1 and 2 is an apparatus for executing an example of the method for producing a compound of the present invention, and includes a transfer pipe 2 having a flow path 20A inside, a detection unit 3, a clogging elimination means 4, and a control unit 5. Hereinafter, each part will be described in detail.

[0030] The transfer pipe [1-1] and the flow path transfer pipe 2 have a flow path 20A inside, and it is a part where the pre-reaction liquid flowing down through the flow path 20A reacts to generate a post-reaction liquid.

[0031] The transfer pipe 2 has a first pipe 21A, a second pipe 21B, a third pipe 21C, a fourth pipe 21D, a fifth pipe 21E, a sixth pipe 21F, a seventh pipe 21G, a confluence part 22A, a confluence part 22B, and a confluence part 22C.

[0032] Also, the flow path 20A has a flow path 210A, a flow path 210B, a flow path 210C, a flow path 210D, a flow path 210E, a flow path 210F, and a flow path 210G.

[0033] The first pipe 21A has a flow path 210A inside, and the flow path 210A is a part where the liquid LA as the pre-reaction liquid flows down.

[0034] The second pipe 21B has a flow path 210B inside, and the flow path 210B is a part where the liquid LB as the pre-reaction liquid flows down.

[0035] The third pipe 21C has a flow path 210C inside, and the flow path 210C is a part where the liquid LC as the pre-reaction liquid flows down.

[0036] The fourth pipe 21D has a flow path 210D inside, and the flow path 210D is a part where the liquid LD as the reaction stopping liquid flows down.

[0037] The fifth pipe 21E has a flow path 210E inside, and the flow path 210E is a part where the liquid LE flows down. The liquid LE may be a post-reaction liquid in which the liquid LA and the liquid LB are mixed and reacted, or may be a mixture of the liquid LA and the liquid LB.

[0038] The sixth pipe 21F has a flow path 210F inside, and the flow path 210F is a part where the liquid LF flows down. The liquid LF may be a post-reaction liquid in which the liquid LC and the liquid LE are mixed and reacted, or may be a mixture of the liquid LC and the liquid LE.

[0039] The seventh pipe 21G has a flow path 210G inside, and the seventh pipe 21G is a part where the liquid LG flows down. The liquid LG is a mixture of the liquid LD and the liquid LF.

[0040] The junction 22A is composed of, for example, a pipe-joint type micromixer and has a port to which the first pipe 21A is connected, a port to which the second pipe 21B is connected, and a port to which the fifth pipe 21E is connected. Liquid LA flowing down the first pipe 21A and liquid LB flowing down the second pipe 21B merge in the junction 22A, and the resulting mixture, liquid LE, flows down the fifth pipe 21E.

[0041] The junction 22B is, for example, composed of a pipe-joint type micromixer and has a port to which the fifth pipe 21E is connected, a port to which the third pipe 21C is connected, and a port to which the sixth pipe 21F is connected. Liquid LE flowing down the fifth pipe 21E and liquid LC flowing down the third pipe 21C merge in the junction 22B, and the resulting mixture, liquid LF, flows down the sixth pipe 21F.

[0042] The junction 22C is, for example, composed of a pipe-joint type micromixer and has a port to which the sixth pipe 21F is connected, a port to which the fourth pipe 21D is connected, and a port to which the seventh pipe 21G is connected. Liquid LF flowing down the sixth pipe 21F and liquid LD flowing down the fourth pipe 21D merge in the junction 22C, and the resulting mixture, liquid LG, flows down the seventh pipe 21G.

[0043] Note that the merging sections 22A to 22C are not limited to the configuration shown in the figure, and may be, for example, a substrate-type micromixer.

[0044] The inner diameter of the first pipe 21A to the seventh pipe 21G, that is, the average width (average diameter) of the cross-section of the flow path 210A to the flow path 210G, is not particularly limited, but is preferably 0.1 mm or more and 100 mm or less, and more preferably 0.2 mm or more and 50 mm or less.

[0045] This allows for smooth transfer of each liquid in each channel, increasing the productivity of the post-reaction liquid, and more effectively preventing clogging of each channel.

[0046] The inner diameters of the first tube 21A to the seventh tube 21G may be the same or different.

[0047] The cross-sectional area of ​​channels 210A to 210G is not particularly limited, but is 0.01 mm². ２ Above 10,000 mm ２ Preferably, it is 0.04 mm ２ 2500mm or more ２ The following is more preferable.

[0048] This allows for smooth transfer of each liquid in each channel, increasing the productivity of the post-reaction liquid, and more effectively preventing clogging of each channel.

[0049] The cross-sectional areas of channels 210A to 210G may be the same or different.

[0050] The cross-sectional shape of the channels 210A to 210G is not particularly limited, but examples include circular, semicircular, elliptical, triangular, or polygonal shapes with more sides.

[0051] The cross-sectional shapes of the channels 210A to 210G may be the same or different.

[0052] The length of the flow path 20A, that is, the total length of the first pipe 21A to the seventh pipe 21G, is set appropriately according to the type of liquid flowing through each flow path, the flow velocity, the temperature, the cross-section of each flow path, etc., but it is preferably 0.1 m or more and 3 m or less, and more preferably 0.5 m or more and 2 m or less.

[0053] This increases the productivity of the post-reaction liquid and allows for more effective and reliable liquid reactions in each channel.

[0054] In such a flow path 20A, flow paths 210A, 210B, and 210C correspond to the "first part" and the "first flow path," while flow paths 210E, 210F, and 210G correspond to the "second part" and the "second flow path."

[0055] Furthermore, when reactions occur within the confluence sections 22A, 22B, and 22C, they correspond to the "second section" and the "second channel," and when no reactions occur within them, they correspond to the "first section" and the "first channel."

[0056] [1-2] Supply Unit Supply unit 1 includes supply unit 1A, supply unit 1B, supply unit 1C, and supply unit 1D. Supply unit 1A supplies liquid LA into the flow path 210A of the first pipe 21A. Supply unit 1B supplies liquid LB into the flow path 210B of the second pipe 21B. Supply unit 1C supplies liquid LC into the flow path 210C of the third pipe 21C. Supply unit 1D supplies liquid LD into the flow path 210D of the fourth pipe 21D.

[0057] The supply units 1A to 1D may have a drive source for dispensing liquid, and may be configured, for example, as a syringe, allowing the liquid to be dispensed manually.

[0058] Furthermore, it is preferable that the supply units 1A to 1D are configured to be switchable between a state of dispensing liquid and a state of dispensing the cleaning solution described later. This allows for smooth switching between the supply process and the cleaning process described later.

[0059] [1-3] In the liquid before and after the reaction in the detection unit, blockage or signs of blockage may occur in the flow path 20A due to the effects of temperature changes, changes in reaction rate, etc. As shown in Figures 1 and 2, the detection unit 3 has detection elements 31A, 31B, 31C, 31E, and 31F for detecting blockage or signs of blockage in the flow path 20A.

[0060] "Clogged" refers to a state in which the cross-sectional shape of the flow path 20A is completely blocked, as well as a state in which it is not completely blocked but the flow rate (flow rate per unit time) in the flow path 20A decreases by, for example, 10% or more. "Signs of clogging" refers to phenomena that occur before the above-mentioned "clogging" occurs, such as discoloration of the flowing liquid or gelation of the liquid, which may develop into "clogging" if not addressed.

[0061] The detection element 31A is installed in the first pipe 21A and detects blockage or signs of blockage in the flow path 210A. The detection element 31A is electrically connected to the control unit 5, and when it receives a first signal S1 from the control unit 5 instructing it to perform blockage or signs of blockage detection, it performs blockage or signs of blockage detection in the flow path 210A. If the detection element 31A detects blockage or signs of blockage, the detection element 31A transmits a second signal S2 indicating blockage or signs of blockage to the control unit 5.

[0062] The detection element 31B is installed in the second pipe 21B and detects blockage or signs of blockage in the flow path 210B. The detection element 31B is electrically connected to the control unit 5, and when it receives a first signal S1 from the control unit 5 instructing it to perform blockage or signs of blockage detection, it performs blockage or signs of blockage detection in the flow path 210B. If the detection element 31B detects blockage or signs of blockage, it transmits a second signal S2 indicating blockage or signs of blockage to the control unit 5.

[0063] The detection element 31C is installed in the third pipe 21C and detects blockage or signs of blockage in the flow path 210C. The detection element 31C is electrically connected to the control unit 5, and when it receives a first signal S1 from the control unit 5 instructing it to perform blockage or signs of blockage detection, it performs blockage or signs of blockage detection in the flow path 210C. If the detection element 31C detects blockage or signs of blockage, the detection element 31C transmits a second signal S2 indicating blockage or signs of blockage to the control unit 5.

[0064] The detection element 31E is installed in the fifth pipe 21E and detects blockage or signs of blockage in the flow path 210E. The detection element 31E is electrically connected to the control unit 5, and when it receives a first signal S1 from the control unit 5 instructing it to perform blockage or signs of blockage detection, it performs blockage or signs of blockage detection in the flow path 210E. If the detection element 31E detects blockage or signs of blockage, the detection element 31E transmits a second signal S2 indicating blockage or signs of blockage to the control unit 5.

[0065] The detection element 31F is installed in the sixth pipe 21F and detects blockage or signs of blockage in the flow path 210F. The detection element 31F is electrically connected to the control unit 5, and when it receives a first signal S1 from the control unit 5 instructing it to perform blockage or signs of blockage detection, it performs blockage or signs of blockage detection in the flow path 210F. If the detection element 31F detects blockage or signs of blockage, the detection element 31F transmits a second signal S2 indicating blockage or signs of blockage to the control unit 5.

[0066] The detection elements 31A, 31B, 31C, 31E, and 31F are not particularly limited, but can be acoustic sensors, optical sensors, flow sensors, or other detection methods such as capacitive sensors, as described below. The detection element 31A will be described as a representative example below, but the detection elements 31A, 31B, 31C, 31E, and 31F may have different detection methods or may be the same.

[0067] [1-3-1] Type of detection unit (sound wave sensor) As shown in Figure 3, the detection element 31A has a transmitting element (not shown) that transmits sound waves and a receiving element (not shown) that receives sound waves. When the detection element 31A receives the first signal S1 from the control unit 5, the transmitting element transmits sound waves toward the flow path 20A, and the receiving element receives the reflected sound waves. In other words, the detection element 31A is a sound wave sensor.

[0068] When a blockage or signs of blockage occur in the flow path 20A, that is, when a solid or gel-like substance is formed in the flow path 20A, the detection element 31A detects the sound waves reflected by the solid or gel-like substance, and the receiving element receives them. As a result, the intensity of the sound waves received by the receiving element increases.

[0069] Furthermore, the detection element 31A transmits a second signal S2 to the control unit 5 regarding information about the intensity of the sound wave received by the receiving element. The control unit 5 compares the detected sound wave intensity with the judgment criterion data (threshold, table, etc.) stored in the memory unit 52 to determine whether a blockage or signs of a blockage have occurred. This allows for more accurate detection of blockages or signs of blockages.

[0070] When the detection element 31A is an acoustic sensor, the detection accuracy of blockages or signs of blockages (especially solid or gel-like substances) can be further improved. Furthermore, because the transmitted sound waves have a broad spread, the detection range can be made relatively wide. In addition, it is advantageous from the standpoint of availability and low cost.

[0071] The frequency of the sound waves transmitted by the transmitting element is not particularly limited, but is preferably between 10 kHz and 400 MHz, and more preferably between 20 kHz and 5 MHz.

[0072] This allows for a wider range of detection of blockages or signs of blockages, regardless of the type of liquid inside.

[0073] In the illustrated configuration, a single detection element 31A houses both a receiving element and a transmitting element. However, the present invention is not limited to this configuration, and the receiving element and the transmitting element may be located on opposite sides of each other via a flow path 20A. In this case, the receiving element and the transmitting element can each be referred to as the detection element 31A.

[0074] [1-3-2] Type of detection unit (optical sensor) As shown in Figure 4, the detection element 31A has a transmitting element (not shown) that transmits detection light and a receiving element (not shown) that receives reflected light of the detection light. When the detection element 31A receives the first signal S1 from the control unit 5, the transmitting element transmits detection light toward the flow path 20A while the receiving element receives the reflected light. In other words, the detection element 31A is a reflective optical sensor.

[0075] In the illustrated configuration, the first pipe 21A is made of a light-transmitting material, in which case the detection element 31A can be installed on the outside of the first pipe 21A. However, the configuration is not limited to this, and if the first pipe 21A is made of a material that does not transmit light, an installation hole is formed in the first pipe 21A and the detection element 31A is installed in the installation hole.

[0076] When a blockage or signs of blockage occur in the flow path 20A, that is, when a solid or gel-like substance is formed in the flow path 20A, the detection element 31A detects the detection light reflected by the solid or gel-like substance, and the receiving element receives the reflected light. As a result, the intensity of the reflected light received by the receiving element increases.

[0077] Furthermore, the detection element 31A transmits a second signal S2 to the control unit 5 regarding information about the intensity of the reflected light received by the receiving element. The control unit 5 compares the detected intensity of the reflected light with the judgment criterion data (threshold, table, etc.) stored in the storage unit 52 to determine whether a blockage or signs of a blockage have occurred. This allows for more accurate detection of blockages or signs of blockages.

[0078] If the detection element 31A is an optical sensor, the accuracy of detecting blockages or signs of blockages (especially discoloration, etc.) can be further improved. In other words, signs of blockages can be detected more accurately at an earlier stage.

[0079] The detection light transmitted by the transmitting element may be light in the visible light region, or it may be light outside the visible light region, such as infrared light.

[0080] In the illustrated configuration, a reflective optical sensor has a receiving element and a transmitting element built into a single detection element 31A. However, the present invention is not limited to this configuration, and a transmissive optical sensor may also be used, in which the receiving element and the transmitting element are installed on opposite sides of each other via a flow path 20A, and the receiving element receives transmitted light. In this case, the receiving element and the transmitting element can each be referred to as the detection element 31A.

[0081] [1-3-3] Types of detection units (flow sensor) As shown in Figure 5, the detection element 31A is composed of a flow sensor that detects the flow rate of the liquid in the flow path 20A. The detection method of the detection element 31A is not particularly limited and examples include Karman vortex type, MEMS type, thermistor type, etc.

[0082] The detection element 31A includes a first element 311A ​​and a second element 312A, which are installed at different positions on the first pipe 21A. The first element 311A ​​is located on the upstream side of the first pipe 21A, and the second element 311B is located on the downstream side of the first pipe 21A.

[0083] When the first element 311A ​​and the second element 311B receive the first signal S1 from the control unit 5, they detect information regarding the flow rate at the location where they are installed.

[0084] If a blockage or signs of a blockage (especially a solid or gel-like substance) occurs in the portion between the first element 311A ​​and the second element 311B within the flow path 20A, the flow rate between the first element 311A ​​and the second element 311B will change.

[0085] The first element 311A ​​and the second element 311B each transmit a second signal S2 related to flow rate information to the control unit 5. The control unit 5 compares the difference in flow rates detected by the first element 311A ​​and the second element 311B with the judgment criterion data (threshold, table, etc.) stored in the storage unit 52 to determine whether a blockage or signs of blockage have occurred. This allows for more accurate detection of blockages or signs of blockage.

[0086] When the detection element 31A is a flow sensor, the accuracy of detecting blockages or signs of blockages can be improved, and detection can be performed over a wider area.

[0087] Furthermore, the detection element 31A is not limited to a configuration having two elements (first element 311A ​​and second element 311B), but may also have a configuration having one element.

[0088] [1-4] Clogging means As shown in Figures 1 and 2, when the clogging means 4 receives a third signal S3 from the control unit 5 instructing the elimination or reduction of a clogging or signs of clogging, it performs the elimination or reduction of a clogging or signs of clogging. In this embodiment, the clogging means 4 includes a vibration applying unit 41 that applies ultrasonic vibration to the part of the flow path 20A where a clogging or signs of clogging have occurred, and a storage tank 42 that stores liquid L.

[0089] The elimination or reduction of a blockage performed by the blockage elimination means 4 means increasing the flow rate per unit time that has decreased due to the blockage. Furthermore, the elimination or reduction of signs of blockage performed by the blockage elimination means 4 means removing or reducing discoloration of the flowing liquid, gelation of the liquid, etc.

[0090] The vibration-applying unit 41 has a vibration source 411. The vibration source 411 is electrically connected to the control unit 5, and its operation is controlled. The control unit 5 appropriately controls the energization conditions (energization timing, energization amount) so that the vibration source 411 generates the desired vibration at the desired timing.

[0091] This vibration can more effectively clear or reduce blockages or signs of blockages. In particular, applying vibration can more effectively detach solid or gel-like substances adhering to the inner wall of the transfer pipe 2.

[0092] The frequency of the vibration generated by the vibration source 411 is preferably, for example, 10 kHz or more and 400 MHz or less, and more preferably 20 kHz or more and 5 MHz or less.

[0093] This allows for more effective resolution or reduction of blockages or signs of blockages.

[0094] Thus, the blockage removal means 4 has a vibration applying unit 41 that applies ultrasonic vibration to the part of the flow path 20A where a blockage or signs of blockage have occurred. This makes it possible to more effectively remove or reduce the blockage or signs of blockage.

[0095] Furthermore, the blockage removal means 4 may have a configuration other than the vibration-applying unit 41, or it may be a combination of the vibration-applying unit 41 and a configuration other than the vibration-applying unit 41.

[0096] Other components besides the vibration-applying unit 41 include, for example, means for physically applying impact to the transfer pipe 2, means for supplying a removal agent into the transfer pipe 2 to chemically remove solid or gel-like substances inside the transfer pipe 2, and means for irradiating the solid or gel-like substances inside the transfer pipe 2 with a laser to remove them.

[0097] The storage tank 42 stores the liquid L that transmits the vibrations generated by the vibration-applying unit 41 to the transfer pipe 2. In other words, the transfer pipe 2 is immersed in the liquid L stored in the storage tank 42. To put it another way, the flow path 20A inside the transfer pipe 2 is immersed in the liquid L stored in the storage tank 42.

[0098] The liquid L in the storage tank 42 is not particularly limited, but examples include water, kerosene, paraffin, mineral oil, electrical insulating oil, etc.

[0099] The temperature of the liquid L in the storage tank 42 is not particularly limited, but is preferably between 5°C and 90°C, and more preferably between 10°C and 40°C. This allows the vibrations generated by the vibration-applying unit 41 to be transmitted to the transfer pipe 2 more efficiently, and makes it easier to maintain the temperature of the liquid L.

[0100] The vibration source 411 is positioned to penetrate the liquid L in the storage tank 42, and the ultrasonic vibrations generated by the vibration applying unit 41 are transmitted to the transfer pipe 2 via the liquid L.

[0101] Thus, the blockage removal means 4 further includes a storage tank 42 for storing liquid L, and at least a portion of the flow path 20A is immersed in liquid L, and the vibration applying unit 41 applies ultrasonic vibrations to at least a portion of the flow path 20A via liquid L. This makes it possible to apply the ultrasonic vibrations generated by the vibration applying unit 41 to the transfer pipe 2 more efficiently and over a wider area.

[0102] Furthermore, in this embodiment, the first pipe 21A, the second pipe 21B, the third pipe 21C, the fourth pipe 21D, the fifth pipe 21E, the sixth pipe 21F, the seventh pipe 21G, the confluence section 22A, the confluence section 22B, and the confluence section 22C are all immersed together in a single storage tank 42, and a single vibration applying unit 41 is used to eliminate or reduce clogging or signs of clogging. This simplifies the configuration of the device.

[0103] However, the configuration is not limited to this, and vibration sources 411 may be provided for each of the first pipe 21A, second pipe 21B, third pipe 21C, fourth pipe 21D, fifth pipe 21E, sixth pipe 21F, seventh pipe 21G, confluence section 22A, confluence section 22B, and confluence section 22C.

[0104] [1-5] Control Unit The control unit 5 shown in Figure 2 includes a processor 51, a storage unit 52, and a communication unit 53. These units are connected to each other so as to be able to communicate with one another, for example, via a bus.

[0105] The processor 51 is composed of, for example, at least one CPU (Central Processing Unit), and reads and executes various programs, such as operation programs, stored in the memory unit 52. The signals generated by the processor 51 (the first signal S1 and the third signal S3) are transmitted to the detection unit 3 and the blockage clearing means 4 via the communication unit 53.

[0106] Specifically, the processor 51 (control unit 5) transmits a first signal S1 to the detection unit 3 to perform detection of a blockage or signs of a blockage. If the detection unit 3 detects a blockage or signs of a blockage, it receives a second signal S2 indicating a blockage or signs of a blockage. Upon receiving the second signal S2, it transmits a third signal S3 to the blockage clearing means 4 to perform a blockage clearing or mitigation of the blockage or signs of a blockage.

[0107] This allows the detection unit 3 to be activated at the appropriate time as needed, and the clogging removal means 4 to be activated when clogging or signs of clogging occur. Therefore, detection, removal, or mitigation of clogging or signs of clogging can be performed more efficiently. Furthermore, if the clogging removal means 4 is configured to be constantly activated, depending on the type of reaction, there is a risk that clogging or signs of clogging may occur due to the activation of the clogging removal means 4. In contrast, the above configuration avoids this risk, suppresses the occurrence of clogging or signs of clogging itself, and improves the quality of the liquid after reaction.

[0108] The memory unit 52 stores various programs and the like executed by the processor 51. Examples of the memory unit 52 include a configuration that includes volatile memory such as RAM (Random Access Memory), non-volatile memory such as ROM (Read Only Memory), and a removable external storage device.

[0109] The communication unit 53 transmits and receives signals between the detection unit 3, the blockage clearing means 4, and external devices using an external interface such as a wired LAN (Local Area Network) or a wireless LAN.

[0110] Furthermore, if the detection unit 3 detects a blockage or signs of a blockage, the detection unit 3 transmits a second signal S2 to the control unit 5 indicating a blockage or signs of a blockage, and the control unit 5 transmits a third signal S3 to the blockage clearing means 4 instructing it to clear or reduce the blockage or signs of a blockage. In other words, in this embodiment, the detection unit 3 transmits a second signal S2 to the blockage clearing means 4 directly or indirectly (indirectly in this embodiment) indicating a blockage or signs of a blockage.

[0111] However, the configuration is not limited to this, and the detection unit 3 may directly transmit a second signal indicating a blockage or signs of a blockage to the blockage clearing means 4.

[0112] In this manner, if the detection unit 3 detects a blockage or signs of a blockage, the detection unit 3 directly or indirectly transmits a signal (second signal S2) indicating a blockage or signs of a blockage to the blockage clearing means 4.

[0113] This allows the detection unit 3 to be activated at the appropriate time as needed, and the blockage removal means 4 to be activated when a blockage or signs of blockage occur. Therefore, blockages or signs of blockages can be detected, resolved, or mitigated more efficiently, and the quality of the liquid after reaction can be improved.

[0114] Furthermore, the flow path 20A includes a first flow path (e.g., flow path 210A) through which a first liquid (e.g., liquid LA) as a pre-reaction liquid flows, a second flow path (e.g., flow path 210B) through which a second liquid (e.g., liquid LB) that reacts with liquid LA flows, a junction (e.g., junction 22A) where flow paths 210A and 210B merge, and a third flow path (e.g., flow path 210E) connected to flow paths 210A and 210B via junction 22A, through which a mixture of liquid LA and liquid LB (e.g., liquid LE) flows. Detection elements (detection elements 31A, 31B, and 31E) are provided in at least one of flow paths 210A, 210B, junction 22A, and 210E (in this embodiment, flow paths 210A, 210B, and 210E).

[0115] This allows for the independent detection, resolution, or mitigation of blockages or signs of blockages in each flow path.

[0116] In this embodiment, the detection elements (detection elements 31A, 31B, 31C, 31E, and 31F) of the detection unit 3 are described as being provided in the first pipe 21A, second pipe 21B, third pipe 21C, fifth pipe 21E, and sixth pipe 21F. However, the present invention is not limited to this configuration, and the elements may also be provided in the junction sections 22A, 22B, and 22C.

[0117] As described above, the reaction apparatus 100 comprises a flow path 20A through which a pre-reaction liquid flows down a first portion of the flow path 20A and through which the pre-reaction liquid reacts in a second portion of the flow path 20A to produce a post-reaction liquid; a detection unit 3 having detection elements (detection elements 31A, 31B, and 31E) for detecting blockage or signs of blockage in the flow path 20A; and a blockage removal means 4 for eliminating or mitigating blockage or signs of blockage.

[0118] This allows the detection unit 3 to be activated at the appropriate time as needed, and the blockage removal means 4 to be activated when a blockage or signs of blockage occur. Therefore, blockages or signs of blockages can be detected, resolved, or mitigated more efficiently, and the quality of the liquid after reaction can be improved.

[0119] Furthermore, the configuration is not limited to activating the blockage removal means 4 only when a blockage or signs of blockage occur. The blockage removal means 4 may be activated periodically (intermittently at predetermined time intervals) regardless of whether a blockage or signs of blockage are detected. In this case, it is possible to prevent the occurrence of blockages or signs of blockage while simultaneously resolving or mitigating blockages or signs of blockage.

[0120] Furthermore, the judgment criteria may differ for each detection element 31A, 31B, 31C, 31E, and 31F. For example, the threshold value on the downstream side, where the priority for detecting blockages or signs of blockages is high, may be set lower than that on the upstream side, where the priority for detecting blockages or signs of blockages is low. This configuration may allow for the detection of slight changes in the detected value to resolve or mitigate blockages or signs of blockages.

[0121] [2] Method for producing the compound Next, a method for producing the compound using the reaction apparatus 100 will be described. The method for producing the compound includes a liquid supply step, a reaction step, a detection step, a blockage removal step, and a cleaning step. These steps are not necessarily performed in this order.

[0122] [2-1] Liquid supply process The liquid supply process is carried out by the supply units 1A to 1D described above. Specifically, supply unit 1A supplies liquid LA into the flow path 210A of the first pipe 21A, supply unit 1B supplies liquid LB into the flow path 210B of the second pipe 21B, supply unit 1C supplies liquid LC into the flow path 210C of the third pipe 21C, and supply unit 1D supplies liquid LD into the flow path 210D of the fourth pipe 21D.

[0123] [2-2] Reaction Process The reaction process is carried out in the fifth pipe 21E and the sixth pipe 21F after the liquid supply process. That is, the reaction process is carried out by flowing the pre-reaction liquid down the flow path 20A and reacting it in at least a portion of the flow path 20A to produce the post-reaction liquid.

[0124] A mixture of liquid LA and liquid LB, or the liquid resulting from their reaction, flows down the fifth pipe 21E. Liquid LA and liquid LB may react at the confluence 22A, or they may react in the fifth pipe 21E.

[0125] Furthermore, a mixture of liquid LC and liquid LE, or the resulting liquid after their reaction, flows down the sixth pipe 21F. The liquid LC and liquid LE may react at the confluence 22B, or they may react in the sixth pipe 21F.

[0126] [2-3] Detection process The detection process is a process of detecting blockage or signs of blockage in at least a portion of the flow path 20A (in this embodiment, the first pipe 21A, the second pipe 21B, the third pipe 21C, the fifth pipe 21E, and the sixth pipe 21F). The detection process is performed by detection elements 31A, 31B, 31C, 31E, and 31F.

[0127] The detection elements 31A, 31B, 31C, 31E, and 31F may be configured to perform detection before the reaction process takes place, during the reaction process, or after the reaction process has taken place. In other words, the detection process only needs to be performed before or after the reaction process.

[0128] As described above, when detection elements 31A, 31B, 31C, 31E, and 31F receive a first signal S1 instructing them to perform detection of blockage or signs of blockage, they perform detection of blockage or signs of blockage in the flow paths 210A, 210B, 210C, 210E, and 210F. However, the configuration is not limited to this, and detection elements 31A, 31B, 31C, 31E, and 31F may be configured to always perform detection of blockage or signs of blockage.

[0129] [2-4] Clogging Clearing Process The clogging clearing process is a process in which, if a clogging or signs of clogging are detected in the detection process, the clogging or signs of clogging are cleared or reduced, and is performed by the clogging clearing means 4 described above. When the clogging clearing means 4 receives a third signal S3 from the control unit 5 instructing it to clear or reduce the clogging or signs of clogging, it clears or reduces the clogging or signs of clogging. The clearing or reduction of clogging or signs of clogging by the clogging clearing means 4 is as described above.

[0130] By performing the liquid supply process, reaction process, detection process, and clogging removal process as described above, the clogging removal means 4 can be activated when clogging or signs of clogging occur. Therefore, clogging or signs of clogging can be eliminated or mitigated more efficiently. Furthermore, if the clogging removal means 4 is configured to be constantly activated, depending on the type of reaction, there is a risk that clogging or signs of clogging may occur due to the activation of the clogging removal means 4. In contrast, the above configuration avoids this risk and suppresses the occurrence of clogging or signs of clogging.

[0131] [2-5] Cleaning Process The cleaning process is a process of cleaning at least a portion of the flow path 20A after the blockage removal process. The cleaning process is carried out by the supply units 1A to 1D described above. Supply unit 1A supplies cleaning liquid into the flow path 210A of the first pipe 21A, supply unit 1B supplies cleaning liquid into the flow path 210B of the second pipe 21B, supply unit 1C supplies cleaning liquid into the flow path 210C of the third pipe 21C, and supply unit 1D supplies cleaning liquid into the flow path 210D of the fourth pipe 21D.

[0132] The cleaning solution can be water, ethers such as tetrahydrofuran and diisopropyl ether, alcohols such as ethanol, methanol, and isopropanol, esters such as ethyl acetate and propyl acetate, amides such as N-methylpyrrolidone and acetamide, etc. The cleaning solution in each channel may be the same or different.

[0133] Furthermore, in the cleaning process, the cleaning solution may be supplied from a supply unit other than supply units 1A to 1D. In other words, the cleaning solution may be supplied from a supply unit dedicated to the cleaning solution, separate from supply units 1A to 1D.

[0134] Thus, the compound manufacturing method includes a cleaning step after the clogging removal step in which at least a portion of the flow path 20A is cleaned. This allows for more reliable removal of the substance (solid matter, gel-like substance, etc.) that caused the clogging or signs of clogging from the flow path 20A. Therefore, the quality of the liquid after the reaction can be improved.

[0135] Furthermore, the system may be configured to perform a cleaning process each time a blockage removal process is performed, or it may be configured not to perform a cleaning process even if a blockage removal process is performed.

[0136] As described above, the method for producing the compound comprises: a reaction step of flowing a pre-reaction liquid down the flow path 210A and reacting it in at least a portion of the flow path 210E to produce a post-reaction liquid; a detection step of detecting a blockage or signs of blockage in at least a portion of the flow path 20A before or after the reaction step; and a blockage removal step of eliminating or mitigating the blockage or signs of blockage if a blockage or signs of blockage are detected in the detection step.

[0137] This allows for a clearing process to be performed when clogging or signs of clogging occur. Therefore, clogging or signs of clogging can be resolved or mitigated more efficiently, and the quality of the liquid after reaction can be improved.

[0138] [3] Reaction in the reaction step As described above, the pre-reaction liquid is a first liquid (for example, liquid LA). In the reaction step, liquid LA is flowed down the first channel of channel 20A (for example, channel 210A), and a second liquid (for example, liquid LB) to react with liquid LA is flowed down the second channel (for example, channel 210B). Liquid LA and liquid LB are mixed at the confluence of channels 210A and 210B (for example, confluence 22A). This allows the liquids to react with each other to produce a post-reaction liquid.

[0139] The types of such reactions are not particularly limited and include, for example, living polymerizations such as living anionic polymerization, living cationic polymerization, and living radical polymerization; polymerization reactions such as addition polymerization, ring-opening polymerization, chain condensation polymerization, and stepwise polymerization; and N-alkylation reactions, oxidation reactions, reduction reactions, and coupling reactions. Below, a representative example of a living polymerization reaction will be described.

[0140] [3-1] Living polymerization reaction: When the reaction in the reaction step is a living polymerization reaction, liquid LA is a liquid containing an initiator, liquid LB is a liquid containing a monomer (second substance, polymerizable substance), and liquid LC is a liquid containing an electrophile. Liquid LD is a liquid that reacts with the radical, anionic, and cationic ends of the growing end to stop the living polymerization reaction.

[0141] [3-1-1] Initiators Examples of initiators include organolithium reagents. The organolithium reagents are not particularly limited, but examples include alkyllithiums such as methyllithium, ethyllithium, propyllithium, butyllithium (n-butyllithium, sec-butyllithium, iso-butyllithium, tert-butyllithium, etc.), pentyllithium, hexyllithium, methoxymethyllithium, and ethoxymethyllithium; benzyllithiums such as α-methylstyryllithium, 1,1-diphenyl-3-methylpentryllithium, and 3-methyl-1,1-diphenylpentyllithium; alkenyllithiums such as vinyllithium, allyllithium, propenyllithium, and butenyllithium; alkynyllithiums such as ethynyllithium, butynyllithium, pentynyllithium, and hexynyllithium; aralkyllithiums such as benzyllithium and phenylethyllithium; aryllithiums such as phenyllithium and naphthyllithium; heterocyclic lithiums such as 2-thienyllithium, 4-pyridyllithium, and 2-quinolyllithium; and alkyllithium magnesium complexes such as tri(n-butyl)magnesium lithium and trimethylmagnesium lithium.

[0142] In particular, alkyllithium is preferred from the viewpoint of high reactivity, and sec-butyllithium is more preferred. Furthermore, one of these may be used alone, or two or more may be used in combination.

[0143] The initiator is supplied to the flow path 210A in a dissolved state in a solvent. The solvent is not particularly limited and includes, for example, linear, branched, and cyclic hydrocarbon solvents. More specifically, examples include butane, butene, pentane, octane, cyclohexane, benzene, toluene, xylene, decalin, tetralin, and their derivatives.

[0144] The initiator content in liquid LA is not particularly limited, but is preferably 0.01 mol / l to 10 mol / l, and more preferably 0.1 mol / l to 5 mol / l. This allows the living polymerization reaction to be carried out more efficiently while more effectively suppressing the occurrence of clogging or signs of clogging.

[0145] [3-1-2] Monomers (second substance, polymerizable substance) Examples of monomers include vinyl aromatic hydrocarbons, (meth)acrylic monomers, and conjugated dienes.

[0146] Examples of the vinyl aromatic hydrocarbons include styrene, styrene derivatives (p-dimethylsilylstyrene, (p-vinylphenyl)methyl sulfide, p-hexynylstyrene, p-methoxystyrene, p-tert-butyldimethylsiloxystyrene, o-methylstyrene, p-methylstyrene, p-tert-butylstyrene, α-methylstyrene, etc.), vinylnaphthalene, vinylanthracene, 1,1-diphenylethylene, and the like.

[0147] Examples of the acrylic monomers mentioned above include methyl acrylate, ethyl acrylate, isopropyl acrylate, isobutyl acrylate, epoxy acrylate, ethylene glycol diacrylate, diethylene glycol diacrylate, trimethylolpropane triacrylate, tetramethylene glycol tetraacrylate, 2-hydroxy-1,3-diacroxypropane, 2,2-bis[4-(acryloxymethoxy)phenyl]propane, 2,2-bis[4-(acryloxyethoxy)phenyl]propane, dicyclopentenyl acrylate, tricyclodecanyl acrylate, tris(acryloxyethyl) isocyanurate, and urethane acrylate.

[0148] Examples of the conjugated dienes include 1,3-butadiene, 2-methyl-1,3-butadiene, 2,3-dimethyl-1,3-butadiene, 1,3-pentadiene, 1,3-hexadiene, and 1,3-cyclohexadiene. These may be used individually or in combination of two or more.

[0149] The monomer is supplied to the channel 210B in a dissolved state in a solvent. The solvent is not particularly limited and includes those described above as the solvent for the initiator.

[0150] The monomer content in the liquid LB is not particularly limited, but is preferably 0.1 mol / l to 10 mol / l, and more preferably 1 mol / l to 5 mol / l. This allows the living polymerization reaction to be carried out more efficiently while more effectively suppressing clogging or signs of clogging.

[0151] Thus, the second liquid (liquid LB) preferably contains a second substance, and the second substance is preferably a polymerizable substance. This allows the living polymerization reaction to be carried out more efficiently.

[0152] A living polymerization reaction occurs by mixing the first liquid (liquid LA) and the second liquid (liquid LB). Thereby, a polymer is obtained by the living polymerization reaction. In particular, the living polymerization reaction is often carried out in a batch system. In the batch system, a cooling device is required to realize a low-temperature environment during the reaction, and further, there is a problem that it is troublesome because it must be atomized or diluted. On the other hand, when the living polymerization reaction is carried out in the reaction device 100, the above problems can be solved.

[0153] Further, by the living polymerization reaction, a polymer of a polymerizable substance (monomer) which is a second substance is obtained. The molecular weight distribution (Mw / Mn) of the obtained polymer is preferably 1.2 or less, more preferably 1.1 or less. Thereby, the quality of the liquid after the reaction, that is, the liquid containing the obtained polymer can be more effectively improved.

[0154] The first liquid (liquid LA) contains a first substance, and the first substance may contain at least one metal element. That is, the liquid LA may be a dispersion liquid. The metal element is not particularly limited, and examples thereof include lithium, magnesium, samarium, cerium, sodium and the like.

[0155] Organometallic compounds and salts containing a metal element are relatively likely to precipitate and tend to cause clogging or signs of clogging, so the configuration of the present invention is particularly effective.

[0156] As the electrophile contained in the electrophile liquid LC in [3-1-3], there is no particular limitation, and examples thereof include dichlorodimethylsilane, trichloromethylsilane, tetrachlorosilane, chlorotrimethylsilane, benzaldehyde, acetophenone, benzophenone, and monomers such as methacrylate, acrylate, and styrene.

[0157] Also, as the electrophile, H ＋ , NO2 ＋ , CH ３ CO ＋ , CH ３ ＋ , C ６ H ５N ２ ＋ Cations such as alcohols, [Fe(CN) ６ ] ３ － , SnCl ４ Oxidizing agents such as AlCl ３ Lewis acids, such as those mentioned above, may also be used.

[0158] By mixing liquid LC containing an electrophile with liquid LE containing a polymer obtained by the reaction of liquid LA and liquid LB, the electrophile reacts with the growth end carbanions of the polymer, yielding a liquid (liquid LF) containing polymers with functional groups at their ends, block polymers, etc.

[0159] The electrophile content in liquid LC is not particularly limited, but is preferably 0.1 mol / l to 10 mol / l, and more preferably 1 mol / l to 5 mol / l. This makes it possible to obtain liquids (liquid LF) containing polymers having functional groups at their ends or block polymers more efficiently.

[0160] Furthermore, when using a nucleophile instead of an electrophile, the nucleophile is OH. － , OR － , CN － OAc － NH ２ － CH (COOC) ２ H ５ ) ２ － Anions like Sn ２＋ Reducing agents such as NH ３ H ２ Lewis bases such as O can be used.

[0161] [3-1-4] Reaction-stopping liquid A liquid LD is, for example, a reaction-stopping solution used to stop a living polymerization reaction. Examples of liquid LDs include liquids containing chlorosilanes such as chlorodimethylsilane, trichloromethylsilane, tetrachlorosilane, and chlorotrimethylsilane, benzaldehyde, acetophenone, benzophenone and carbonyl compounds, and alcohols such as ethanol and methanol. In addition, as a liquid LD, for example, those containing 4-tert-butylpyrocatechol, tert-butylhydroquinone, 1,4-benzoquinone, dibutylhydroxytoluene, 1,1-diphenyl-2-picrylhydrazyl, hydroquinone, mequinol, phenothiazine, etc. can be used as radical-stopping agents.

[0162] <Second Embodiment> Figure 6 is a schematic diagram showing a reaction apparatus according to the second embodiment of the present invention. The second embodiment of the reaction apparatus of the present invention will be described below with reference to Figure 6, but the explanation will focus on the differences from the above embodiment, and similar matters will be omitted.

[0163] [4] Reaction apparatus As shown in Figure 6, the reaction apparatus 100 according to this embodiment has a plurality of flow paths 20A. The flow paths 20A are composed of internal flow paths of supply section 1A, supply section 1B, supply section 1C, first pipe 21A, second pipe 21B, third pipe 21C, fifth pipe 21E, sixth pipe 21F, confluence section 22A, and confluence section 23B, and a plurality of these are provided.

[0164] Each channel 20A is connected such that the sixth pipe 21F merges with each other. Furthermore, after each channel 20A merges, a supply unit 1D is connected so that liquid LD is supplied.

[0165] Furthermore, each flow path 20A is provided with a detection element 31A, a detection element 31B, a detection element 31C, a detection element 31E, and a detection element 31F, respectively. The installation positions and configurations of these elements are as described in the first embodiment.

[0166] As described above, the reaction apparatus 100 according to this embodiment includes a flow path 20A and a plurality of pairs of detection elements (detection element 31A, detection element 31B, detection element 31C, detection element 31E, and detection element 31F).

[0167] This prevents the cross-sectional area of ​​each channel 20A from becoming too large, while still allowing for the generation of more post-reaction liquid. Therefore, productivity can be more effectively increased while ensuring that the reactions of each liquid proceed smoothly.

[0168] In particular, even if a blockage or signs of blockage occur in the flow path 20A, the blockage or signs of blockage can be resolved or mitigated only in the affected flow path 20A. Furthermore, by performing the cleaning process only on the flow path 20A where a blockage or signs of blockage has occurred, the flow paths 20A that do not have a blockage or signs of blockage can continue to operate. As a result, productivity can be increased more effectively.

[0169] [5] Method for producing the compound The method for producing the compound according to this embodiment includes a liquid supply step, a reaction step, a detection step, a blockage removal step, and a washing step, similar to the first embodiment.

[0170] In the detection process, the detection elements 31A, 31B, 31C, 31E, and 31F of each flow path 20A can be operated independently.

[0171] Furthermore, in the declogging process, the declogging or signs of declogging can be resolved or mitigated only in the flow path 20A where a blockage or signs of declogging have occurred.

[0172] Furthermore, in the cleaning process, cleaning can be performed only on the flow path 20A where clogging or signs of clogging have occurred.

[0173] <Third Embodiment> Figure 7 is a schematic diagram (cross-sectional view) showing a reaction apparatus according to the third embodiment of the present invention.

[0174] The third embodiment of the reaction apparatus of the present invention will be described below with reference to Figure 7, focusing on the differences from the previous embodiment, and similar matters will be omitted.

[0175] The present invention is not limited to cases where multiple channels merge, as in the first embodiment, but can also be applied to configurations where the channels do not merge, such as in this embodiment, where a reaction occurs within a single channel and a liquid is produced after the reaction.

[0176] [6] Reaction apparatus As shown in Figure 7, the reaction apparatus 100 according to this embodiment has a flow path 20B and a catalyst 90 that reacts with liquid LX as a pre-reaction liquid flowing down the flow path 20B.

[0177] The catalyst 90 is composed of, for example, a porous material and is configured to come into contact with the liquid LX as it passes through. When the liquid LX passes through the catalyst 90, a reaction occurs, and liquid LY, which is a liquid after the reaction, is produced.

[0178] In other words, in the flow path 20B, the part upstream of the catalyst 90 is the first part 201B, and the part downstream of the catalyst 90 is the second part 202B.

[0179] Examples of reactions that occur in the reaction apparatus 100 according to this embodiment include oxidation reactions, reduction reactions, carbon-carbon coupling reactions, metathesis reactions, N-alkylation reactions, polymerization reactions, and the like.

[0180] Examples of reaction substrates contained in liquid LX include hydrogenated compounds such as olefins, toluene, and naphthalene; oxidized compounds such as alcohols; and compounds containing halogen atoms, boron atoms, or metal atoms that undergo carbon-carbon bonding reactions.

[0181] Examples of catalyst 90 include solid catalysts for hydrogenation, solid oxidation catalysts, and solid catalysts for carbon-carbon coupling.

[0182] Furthermore, a detection element 32A is provided in the first portion 201B, and a detection element 32B is provided in the second portion 202B.

[0183] When detection elements 32A and 32B receive the first signal S1 from the control unit 5, they detect information regarding the flow rate (flow rate per unit time) at the location where they are installed.

[0184] If a blockage or signs of a blockage (particularly a solid or gel-like substance) occurs in the first section 201B or the second section 202B, the flow rate detected by either detection element 32A or detection element 32B changes.

[0185] Detection elements 32A and 32B each transmit a second signal S2 related to flow rate information to the control unit 5. The control unit 5 compares the difference in flow rates detected by detection elements 32A and 32B with judgment criterion data (thresholds, tables, etc.) stored in the storage unit 52 to determine whether a blockage or signs of blockage have occurred. This allows for more accurate detection of blockages or signs of blockage.

[0186] Note that one of the detection elements 32A and 32B may be omitted. Also, detection elements 32A and 32B may be sensors of other detection methods, such as optical sensors or acoustic sensors.

[0187] As described above, the reaction apparatus 100 in this embodiment is provided in the flow path 20B and includes a catalyst 90 that reacts with the pre-reaction liquid flowing down the flow path 20B. The detection elements (detection elements 32A, detection elements 32B) are provided in at least one (both in this embodiment) of the first portion 201B upstream of the catalyst 90 and the second portion 202B downstream of the catalyst 90 of the flow path 20B. This makes it possible to detect blockages or signs of blockages in the parts where the pre-reaction liquid and post-reaction liquid flow down. In addition, when a blockage or signs of blockage occur, a blockage removal means 4 (not shown) can be activated. Therefore, detection of blockages or signs of blockages, and removal or reduction of blockages can be performed more efficiently, and the quality of the post-reaction liquid can be improved.

[0188] [7] Method for producing the compound The method for producing the compound according to this embodiment includes a liquid supply step, a reaction step, a detection step, a blockage removal step, and a washing step, similar to the embodiments described above.

[0189] In the detection process, detection element 32A and detection element 32B can be operated independently.

[0190] Furthermore, the declogging process can eliminate or reduce blockages or signs of blockages in the flow path 20B. In other words, in this embodiment, the declogging process can be performed collectively on the first section 201B and the second section 202B.

[0191] Furthermore, the cleaning process can be used to clean the flow path 20B. In this embodiment, the cleaning process can be performed collectively on the first section 201B and the second section 202B.

[0192] Although the reaction apparatus and compound manufacturing method of the present invention have been described above, the present invention is not limited to the embodiments described above. Furthermore, the configuration of the second embodiment and the configuration of the third embodiment may be combined. That is, a configuration in which a plurality of flow channels 20B in which catalyst 90 is installed converges on at least one of the upstream and downstream sides of catalyst 90, as shown in Figure 7, is also possible. In this case, the productivity of the post-reaction liquid can be increased without increasing the cross-sectional area of ​​the flow channels 20B. In other words, productivity can be increased while more effectively promoting the reaction.

[0193] Furthermore, for example, in the reaction apparatus and compound manufacturing method of the present invention, each part and process of each embodiment may be replaced with any component or process having a similar function, or any component or process may be added to each embodiment.

[0194] According to the present invention, it is possible to provide a reaction apparatus and a method for producing compounds that can improve the quality of the post-reaction liquid while preventing or suppressing clogging of the flow path. Therefore, the present invention has industrial applicability.

[0195] 1 Supply Unit 1A Supply Unit 1B Supply Unit 1C Supply Unit 1D Supply Unit 2 Transfer Pipe 3 Detection Unit 4 Resolution Means 5 Control Unit 20A Flow Channel 20B Flow Channel 21A First Pipe 21B Second Pipe 21C Third Pipe 21D Fourth Pipe 21E Fifth Pipe 21F Sixth Pipe 21G Seventh Pipe 22A Confluence Section 22B Confluence Section 22C Confluence Section 31A Detection Element 31B Detection Element 31C Detection Element 31E Detection Element 31F Detection Element 32A Detection Element 32B Detection Element 41 Vibration Imparting Unit 42 Storage Tank 51 Processor 52 Memory Unit 53 Communication Unit 90 Catalyst 100 Reaction Device 201B First Part 202B Second Part 210A Flow path 210B Flow path 210C Flow path 210D Flow path 210E Flow path 210F Flow path 210G Flow path 311A ​​First element 311B Second element 411 Vibration source L Liquid LA Liquid LB Liquid LC Liquid LD Liquid LE Liquid LF Liquid LG Liquid LX Liquid LY Liquid S1 First signal S2 Second signal S3 Third signal

Claims

1. A reaction apparatus comprising: a flow path through which a pre-reaction liquid flows down a first portion of the flow path, and through which the pre-reaction liquid reacts in a second portion of the flow path to produce a post-reaction liquid; a detection unit having a detection element for detecting blockage or signs of blockage in the flow path; and a blockage clearing means for eliminating or mitigating the blockage or signs of blockage.

2. The reaction apparatus according to claim 1, wherein, if the detection unit detects the blockage or signs of the blockage, the detection unit transmits a signal indicating the blockage or signs of the blockage to the blockage clearing means, either directly or indirectly.

3. The reaction apparatus according to claim 1, further comprising a control unit, wherein the control unit transmits a first signal to the detection unit to perform detection of the blockage or signs of blockage, the control unit receives a second signal indicating the blockage or signs of blockage when the detection unit detects the blockage or signs of blockage, and the control unit transmits a third signal to the blockage clearing means to perform clearing or mitigating the blockage or signs of blockage when the second signal is received.

4. The reaction apparatus according to claim 1, wherein the flow path comprises a first flow path through which a first liquid as the pre-reaction liquid flows, a second flow path through which a second liquid that reacts with the first liquid flows, a confluence where the first flow path and the second flow path merge, and a third flow path connected to the first flow path and the second flow path via the confluence, and the detection element is provided in at least one of the first flow path, the second flow path, the confluence, and the third flow path.

5. The reaction apparatus according to claim 1, comprising a catalyst provided in the flow path for reacting the pre-reaction liquid flowing down the flow path, wherein the detection element is provided in at least one of the first portion of the flow path upstream of the catalyst and the second portion downstream of the catalyst.

6. The reaction apparatus according to any one of claims 1 to 3, wherein the detection element is an acoustic sensor.

7. The reaction apparatus according to any one of claims 1 to 3, wherein the detection element is an optical sensor.

8. The reaction apparatus according to any one of claims 1 to 3, wherein the detection element is one of the flow sensors.

9. The reaction apparatus according to any one of claims 1 to 3, wherein the blockage clearing means has a vibration applying unit that applies ultrasonic vibration to the portion of the flow path that is blocked or shows signs of blockage.

10. The reaction apparatus according to claim 9, wherein the declogging means further comprises a storage tank for storing liquid, at least a portion of the flow path is immersed in the liquid, and the vibration applying unit applies the ultrasonic vibration to at least a portion of the flow path via the liquid.

11. The reaction apparatus according to any one of claims 1 to 3, comprising a plurality of pairs of the flow path and the detection element.

12. A method for producing a compound, comprising: a reaction step of allowing a pre-reaction liquid to flow down a channel and causing a reaction in at least a portion of the channel to produce a post-reaction liquid; a detection step of detecting a blockage or signs of blockage in at least a portion of the channel before and after the reaction step; and a blockage removal step of eliminating or mitigating the blockage or signs of blockage if the blockage or signs of blockage are detected in the detection step.

13. A method for producing a compound according to claim 12, further comprising a cleaning step of cleaning at least a portion of the flow path after the blockage removal step.

14. The method for producing a compound according to claim 12, wherein the pre-reaction liquid is a first liquid, and in the reaction step, the first liquid is allowed to flow down a first channel of the flow path, a second liquid to react with the first liquid is allowed to flow down a second channel, and the first liquid and the second liquid are mixed at the confluence of the first channel and the second channel.

15. A method for producing the compound according to claim 14, wherein the first liquid comprises a first substance, and the first substance comprises at least one metal element.

16. The method for producing the compound according to claim 14, wherein the second liquid contains a second substance, and the second substance is a polymerizable substance.

17. A method for producing the compound according to claim 16, wherein a living polymerization reaction occurs by mixing the first liquid and the second liquid.

18. The method for producing the compound according to claim 17, wherein a polymer of the second substance is obtained by the living polymerization reaction, and the molecular weight dispersion of the polymer is 1.2 or less.

Images