Sampler with fractional collection, storage and processing, and sample distribution

Abstract

An apparatus for fractional sample collection and distribution, the apparatus includes a sampler configured to be in fluid communication with one or more fluid source containers, the sampler has a first arm configured to direct the fluid to a sample retaining receptacle coupled to the sampler, the sampler has a second arm configured to be in fluid communication with the sample retaining receptacle, the second arm is in fluid communication with an analytical device, a controller is electrically coupled to the sampler and the analytical device to instruct for movement of the fluid from the second arm to the analytical device, the controller electrically coupled to an external system for function of the external system.

Description

SAMPLER WITH FRACTIONAL COLLECTION, STORAGE AND PROCESSING,AND SAMPLE DISTRIBUTION CROSS-REFERENCES TO RELATED APLICATIONS

[0001] This application claims priority from and the benefit of U.S. Provisional Application No.63 / 743,935, entitled “SAMPLER WITH FRACTIONAL COLLECTION, STORAGE AND PROCESSING, AND SAMPLE DISTRIBUTION”, filed January 10, 2025.FIELD

[0002] The present inventions relate to the field of sampling. The present inventions more specifically relate to the field of reactor sampling, collection, storage processing, and distribution.BACKGROUND

[0003] It is known to collect samples from a reactor, vessel, container, process stream or the like for processing and testing. Sampling is taken of organic and non-organic material. Sampling allows for testing of reduced volumes of material. As a result, multiple samples may be taken from a material to conduct the same or similar number of different tests on the material.

[0004] In the art, a single sample is taken. That single sample is then processed by the respective sampling apparatus for testing. A subsequent sample taken by the same sampler is delayed until the first sample is taken and processed. Thus, the collection of, processing and testing of a first sample delays collection of subsequent samples. As a result, sampling or collection of a material sample is undertaken from a single material source, for example a reactor, vessel, container, process stream. In the art, sampling and processing of multiple samples from multiple materials sources requires multiple sampling apparatus. Alternatively, where a single sample apparatus is used, the collection of multiple samples requires delayed sampling for subsequent samples. Each sample is collected, processed, and tested. Subsequent collection of additional samples requires the subsequent samples to be collected at a different time and potentially at a different temperature. As a result, a first sample may be taken under a first condition (for example metabolite concentration). While subsequent samples may be taken under subsequentconditions which are different from the first condition. Therefore, collection, processing, testing, and comparison of sampling tests is difficult. The reason for the difficulty is the respective samples are taken at different times and under different conditions, which influences and changes the sample.

[0005] Accordingly, there is a need for an apparatus that can collect multiple samples (e.g., contemporaneously) from one or more reactors, vessels, containers, process streams or the like. Accordingly, there is a need for an apparatus that can store samples from one or more reactors, vessels, containers, process streams or the like. Accordingly, there is a need for an apparatus that can access such multiple samples so that the multiple samples can be tested and / or retested without necessarily acquiring additional samples. There is also a need for an apparatus that does sample preparation.

[0006] There is also a need for an apparatus that does sample auto dilutions. There is also a need for an apparatus that is able to communicate and / or control external analytical instruments, and / or obtain data from such instruments. There is also a need for an apparatus that can control a reactor, process stream, or other system process (e.g., based on analytical data). There is also a need for an apparatus that can send analytical data to a control system. There is also a need for an apparatus that can send analytical data to a historian.

[0007] There is also a need for an apparatus that is configured to communicate with and / or be access through a web portal (e.g., a cloud based portal). There is also a need for an apparatus that includes component parts that require less cleaning and / or are disposable.SUMMARY

[0008] In the prior art, sample collection, processing, and testing is limited to samples collected and processed and tested in subsequent order and not contemporaneous in time. Thus, the samples are exposed to different conditions, for example varying temperature. Accordingly, an apparatus that can collect multiple samples (e.g., contemporaneously) at the same time or within close proximity of time to one another is provided. The apparatus has the capability to collect samples from one or more material sources, for example: reactors, vessels, containers, and process streams. Accordingly, the apparatus can store samples from one or more materialsources. With that, the apparatus can access such multiple samples so that the multiple samples can be tested and / or retested without necessarily acquiring additional samples. The apparatus is capable of sample preparation. The apparatus does sample auto dilutions. Further, the apparatus is capable of communicating with and / or control external analytical instruments. Additionally, the apparatus is capable of obtaining data from such instruments. The apparatus is capable of controlling the amount of sample delivered from a material source. The apparatus is capable of controlling the process applied in the material source based on analytical data.Further, the apparatus is capable of communicating analytical data to a control system and a historian. Therefore, the apparatus provides multiple contemporaneous samples to be taken. The apparatus provides contemporaneous proration of samples for testing. Thus, the apparatus addresses the need to ensure multiple samples are collected, stored, and tested under the same conditions. Therefore, the apparatus ensures comparison of contemporaneous samples, samples collected, prepared and stored under the same conditions.

[0009] An example apparatus for fractional sample collection and distribution is described herein. The apparatus comprises the following. A sampler configured to be in fluid communication with one or more fluid source containers having a fluid. The sampler has a first arm configured to direct the fluid to a sample retaining receptacle coupled to the sampler. The sampler has a second arm configured to be in fluid communication with the sample retaining receptacle. The second arm is in fluid communication with an analytical device. A controller is electrically coupled to one or more of the sampler and the analytical device. The controller has an instruction for movement of the fluid from the second arm to the analytical device, with the controller electrically coupled to an external system.

[0010] An alternative example apparatus for fractional sample collection and distribution is described herein. The apparatus comprises the following. A sampler is configured to be in fluid communication with one or more fluid source containers having a fluid. The sampler having a first arm configured to direct the fluid to a sample retaining receptacle coupled to the sampler. The sampler has a second arm configured to be in fluid communication with the sample retaining receptacle. The second arm is in fluid communication with an analytical device; and deliver the fluid to one or more analytical devices. The first arm is a first gantry and the second arm being a second gantry separate from the first gantry, with the first gantry and the second gantry movingalong a frame. A controller electrically coupled to one or more of the sampler and the analytical device with the controller having instruction for movement of the fluid from the second arm to the analytical device, with the controller electrically coupled to an external system.

[0011] An alternative example apparatus for fractional sample collection and distribution is described herein. The apparatus comprises the following. A sampler configured to be in fluid communication with one or more fluid source containers having a fluid. The sampler has a first arm configured to direct the fluid to a plurality of sample retaining receptacles coupled to the sampler. The sampler has a second arm configured to be in fluid communication with the sample retaining receptacles, with the first arm being separate from the second arm. The second arm is operatively connected to a pump, with the pump being one or more of integrated into the second arm and positioned external to the second arm. The second arm is in fluid communication with an analytical device. A controller is electrically coupled to one or more of the sampler and the analytical device with the controller having and instruction for movement of the fluid from the second arm to the analytical device, with the controller electrically coupled to an external system. The controller is configured to communicate with and / or be accessed through a web portal comprising a cloud based portal

[0012] The example apparatus may further comprise the following. The controller may be configured to receive data from the analytical device as to the fluid and to communicate one or more of the data and a command to the external system. The external system may comprise a control system configured to control a fluid transfer from one or more of a reactor, the movement of the fluid from the second arm to the analytical device, a process stream, a system feed and a system process based at least in part on the data. The external system may comprise a historian, and the controller is configured to communicate the data to the historian. The controller may be configured to communicate with and / or be accessed through a web portal comprising a cloud based portal. A temperature control system may be configured to direct a temperature of one or both of the sampler and the fluid, with one or more of the one or more well plates and vial racks being temperature controlled. The sample retaining receptacle may be one or more well plates or vial racks positioned on a base of the sampler, with a first well plate or vial rack configured for a retention of the fluid and a second well plate or vial rack configured for a second retention of thefluid as process samples, with the first well plate and the second well plate are adjoining. The sample retaining receptacle has a disposable component.

[0013] The sample retaining receptacle has a disposable component. One or both of the first arm and the second arm may be a transporter of a predetermined amount of the fluid from the sample retaining receptacle to a to one or both of the first and second sample retaining receptacle, with the second arm having an addition of one or more of a dilutant and a reagent to the second sample retaining receptacle. A multi-position valve fluidly may be coupled to the second arm, with the multi-position valve and configured to have one or more of a dilutant, a reagent, a waste receptacle, and a cleaning solution. A motor rotatably may be coupled one or both of a multi-position valve and a needle coupled to the multi-position valve. The multiposition valve may comprise a disposable multi-position valve. The first arm may have a plurality of needles for transferring fluid from the one or more fluid source containers. The analytical device being a plurality of analytical devices and the sampling retaining receptacle being a plurality of sampling retaining receptacles. One or both of the first arm and the second arm may be in fluid connection with at least one sensor. The sensor may have a monitor to the first arm and at least one second sensor having a second monitor from the second arm.

[0014] The second arm may be operatively connected to a pump, with the pump comprising one or more of a positive displacement pump, a peristaltic pump, a diaphragm pump, a needle pump, a piezo pump, and a vacuum pump, with the pump being one or more of integrated into the second arm and positioned external to the second arm. One or more of a dilution device and a reagent delivery device may be configured to have one or both of a dilutant and a reagent addition to the fluid. One or both of the first arm and the second arm may have a gantry, the gantry having a seal at an operation opening, with the seal having a first sealing member and a second sealing member positioned substantially parallel to one another along a length of the operational opening, with the first sealing member and the second sealing member configured to engage a moving component of the gantry. The one or more fluid source containers may be one or more of reactors, vessels, process streamers, containers.

[0015] One or both of the first gantry and the second gantry has a seal at an operation opening, with the seal having a first sealing member and a second sealing member positionedsubstantially parallel to one another along a length of the operational opening, with the first sealing member and the second sealing member configured to engage a moving component of the respective gantry. The controller is configured to receive a data from the analytical device as to the fluid and to communicate one or more of the data and a command to the external system, with the external system comprising a control system configured to control one or more of a reactor, the movement of the fluid from the second arm to the analytical device, a process stream, a system feed and a system process based at least in part on the data. The external system may comprise a control system configured to control one or more of a reactor, the movement of the fluid from the second arm to the analytical device, a process stream, a system feed and a system process based at least in part on a data

[0016] These and other features, advantages, and embodiments of apparatus and methods according to the invention are described in, or are apparent from, the following detailed descriptions of various examples of embodiments.BRIEF DESCRIPTION OF DRAWINGS

[0017] Various examples of embodiments of the systems, devices, and methods according to this invention will be described in detail, with reference to the following figures, wherein:

[0018] FIG. l is a perspective view of an apparatus for fractional sample collection, storage, processing, and distribution, according to various examples of embodiments.

[0019] FIG. 2 is a perspective view of the apparatus of FIG. 1 illustrating the application of retaining receptacles.

[0020] FIG. 3 is a side view of the apparatus of FIG. 1.

[0021] FIG. 4 is a focused view of a first gantry of the apparatus of FIG. 1.

[0022] FIG. 5 is a focused view of a second gantry of FIG. 1.

[0023] FIG. 6 is a focused view of the interaction of the first gantry to a lateral gantry rail.

[0024] FIG. 7 is a focused view of an interior of the first gantry.

[0025] FIG. 8 is a perspective view of the apparatus, illustrating sixteen needles incorporated as part of the first gantry with a sensor communicatively coupled to each needle.

[0026] FIG. 9 is a perspective view of the apparatus as illustrated in FIG. 8, further illustrating a fluid connection to a material source.

[0027] FIG. 10 is a perspective view of the apparatus, illustrating the second gantry coupled to an external pump.

[0028] FIG. 11 is a perspective view of the apparatus as illustrated in FIG. 10, further illustrating a fluid connection to an analytical device.

[0029] FIG. 12 is a focused view of the first gantry, illustrating a pump device connected to the second gantry.

[0030] FIG. 13 is a system view illustrating the apparatus connection to a controller and external system.

[0031] FIG. 14 is a second aspect of the sixteen needles applied to the first gantry with a sensor communicatively coupled to each needle.

[0032] FIG. 15 is a perspective view of a second embodiment of the apparatus.

[0033] It should be understood that the drawings are not necessarily to scale. In certain instances, details that are not necessary to the understanding of the invention or render other details difficult to perceive may have been omitted. It should be understood, of course, that the invention is not necessarily limited to the particular constructions / embodiments illustrated herein.

[0034] Within the scope of this application, it is expressly intended that the various aspects, embodiments, examples, and alternatives set out in the preceding paragraphs, the following description, the claims, and / or the drawings, and in particular the individual features thereof, may be taken independently or in any combination. That is, all embodiments and all features of any embodiment can be combined in any way and / or combination, unless such features are incompatible. The applicant reserves the right to change any originally filed claim or file anynew claim accordingly, including the right to amend any originally filed claim to depend from and / or incorporate any feature of any other claim although not originally claimed in that manner.DETAILED DESCRIPTION

[0035] Disclosed herein is an apparatus to collect multiple samples (e.g., contemporaneously) at the same time or within close proximity of time to one another is provided. The apparatus has the capability to collect samples from one or more material sources, for example: reactors, vessels, containers, and process streams. Accordingly, the apparatus can store samples from one or more material sources. With that, the apparatus can access such multiple samples so that the multiple samples can be tested and / or retested without necessarily acquiring additional samples. The apparatus is capable sample preparation. The apparatus does sample auto dilutions. Further, the apparatus is capable of communicating with and / or control external analytical instruments. Additionally, the apparatus is capable of obtaining data from such instruments. The apparatus is capable of controlling the amount of sample delivered from a material source. The apparatus is capable of controlling the process applied in the material source based on analytical data. Further, the apparatus is capable of communicating analytical data to a control system and a historian. Therefore, the apparatus provides multiple contemporaneous samples to be taken. The apparatus provides contemporaneous proration of samples for testing. Thus, the apparatus addresses the need to ensure multiple samples are collected, stored, and tested under the same conditions. Therefore, the apparatus ensures comparison of contemporaneous samples, samples collected, prepared and stored under the same conditions.

[0036] With attention Figure 1, an embodiment of an apparatus for fractional sample collection, storage, processing and distribution, a sampler, 100 is described. The sampler 100 may have various constructions. However, at least one feature of the sampler 100 is provided in various constructions of the sampler 100. The sampler 100 is a defined unit for collecting, processing, storing, and transferring samples for analytical testing. The sampler 100 comprises a housing 105, a first arm, 110, and a second arm 115. The first arm 110 and the second arm 115 are slidably attached to the housing 105. In the preferred embodiment, the housing 105 is a frame. Preferably, the housing 105 is a gantry frame 120. The gantry frame 120 comprises two atleast substantially parallel rails 125 extending a length 130 of the gantry frame 120. Gantry frame 120 and frame 105 shall be applied interchangeably for discussion. The length 130 of the frame 105 is a dimension of the frame 105 within which the first arm 110 and the second arm 115 are separated from one another. The first arm 110 and the second arm 115 are separate and distinct, unconnected, features of the sampler 100. Alternatively, the first arm 105 and the second arm 110 may be connected.

[0037] A distance between the rails 125 defines a width, or width dimension, of the sampler 100. With that the sampler has a base or bed 140. The base 140 defines the lower or bottom feature of the sampler 100. The rails 125 are positioned above the base and extend substantially parallel to the base 140. The rails are positioned above the base 140 with a raising structure 145, for example a frame or a closed structure. A cavity 150 of the sampler 100 is defined by the base 140 and the raising structure 145. Further the rails 125 are positioned so that the raising structure 145 is between or separates the base 140 140 and the rails 125. The rails 125, thus, define an upper edge or limit of the cavity 150.

[0038] A first gantry 155 is positioned between the rails 125. The gantry 155 extends to, if not proximate to each rail 125. The gantry is positioned proximate to a first end 170 of the base 140 or sampler 100. The first end 170 is opposite a second end 175 of the base 140 or sampler 100. The distance between the first end 170 and the second end 175 is the length 130. The gantry 155 is attached to each rail with a mobility mechanism 160. The mobility mechanism 160 allows for the gantry 155 to traverse the length 130 along the rails 125. The gantry 155 has the first arm 110 slidably attached to the gantry. The first arm 110 is positioned in the direction of the cavity 150. A second gantry 165 is positioned proximate to the second end 175. The second gantry 165 is positioned between the rails 125, similar to the first gantry 155. The gantry 165 extends to, if not proximate to each rail 125. The gantry 165 is attached to each rail with a mobility mechanism 160, similar to that of the first gantry 155. The mobility mechanism 160 allows for the gantry 165 to traverse the length 130 along the rails 125. The gantry 165 has the second arm 115 slidably attached to the gantry 165. The first arm 115 is positioned in the direction of the cavity 150. With that, the first arm 110 and the second arm 115 are positioned on the respective gantries (155, 165) such that the first arm 110 and the second arm 115 face or are opposite one another.Proximate to each end (170, 175) is positioned a cleaning station 180. The cleaning station allows for the apparatus 110 to clean the needles 185 fluidly attached to each arm (110, 115).

[0039] With attention to FIGs. 1 and 2, illustrates the apparatus with application of retaining receptacles 190. With that, in various examples of the apparatus 100, the receptacles includes well plates and / or vial racks for retaining samples. In various embodiments, the fractional the fractional collector includes well plates for retaining processed samples (e.g., samples that have had diluting agents or reagents added thereto). Receptacles 190 may be for example well plates for retaining samples and the well plates for retaining processed samples are adjoining. Plate racks (not illustrated in the figures) with such well plates may be disposable. Receptacles may be disposable to reduce cleaning requirements. A first retaining receptacle 190A is positioned within the cavity 150 proximate to at least one of the first end 170 and the first arm 110. The first receptacle 190A contains a plurality of first receptacle openings (195, 195A). These openings 195 A are positioned in the direction of the first arm 110 and a needle opening of the needle 200. Each opening defines a receptacle cavity (not illustrated in the figures) within the receptacle 190A. Thus, when the apparatus 100 is in operation a needle 185 positioned on or attached to the first arm 110 enters a respective opening 195 A such that the needle opening 200 enters the cavity defined by the respective opening 195 A. There are two receptacles 190A positioned substantially parallel to one another within the cavity 150. Alternatively, there may be more than two or less than two receptacles positioned in the cavity 150.

[0040] A second retaining receptacle 190B is positioned within the cavity 150 proximate to at least one of the second end 175 and the second arm 115. The second receptacle 190B contains a plurality of second receptacle openings (195, 195B). These openings 195B are positioned in the direction of the second arm 115 and a needle opening of the needle 200. Each opening defines a receptacle cavity (not illustrated in the figures) within the receptacle 190B. Thus, when the apparatus 100 is in operation a needle 185 positioned on or attached to the second arm 115 enters a respective opening 195B such that the needle opening 200 enters the cavity defined by the respective opening 195B. There are two receptacles 190B position substantially parallel to one another within the cavity 150. Alternatively, there may be more than two or less than two receptacles positioned in the cavity 150. Further, the receptacle 195B is positioned proximate to the first receptacle 195 A within the cavity 150.

[0041] With attention to FIGs 1-3 and 6, motive of the gantries (155, 165) is described. As illustrated in FIG. 6, the gantries (155, 165), illustrated with the first gantry 155, have a mobility mechanism 160 attached to the gantry (155, 165). Preferably two mobility mechanisms 160 are attached to each gantry (155, 165). The pair of mechanisms 160 are attached to a respective gantry such that the mechanisms contact the rails 125 when the gantry (155, 165) is positioned in an operational position in the cavity 150. An operational position is the position of the gantry (155, 165) in order to perform the functions of the gantry (155, 165) as described. The mobility mechanism 160 comprises any mechanism to attach the gantry (155, 165) to the rails 125 and allow for movement of the gantry (155, 165) along the rails 125. For example, as illustrated, the mechanism 160 may comprise a plurality of wheels 205, for example four wheels 205, positioned above and below each respective rail 125. At least one mobility mechanism 160 of at least one of the gantries (155, 165) is attached to a drive mechanism 210. The drive mechanism 210 attached to the first gantry 155 moves the first gantry 155 along the length 130, towards and away from the second gantry 165. The drive mechanism 210 attached to the second gantry 165 moves the second gantry 165 along the length 130, towards and away from the first gantry 155. The drive mechanism 210 may be any type of motor, drive, or chain driven system, for example the drive mechanism, 210 may include a chain 215 attached to one or both of the gantries (155, 165) to advance a respective gantry (155, 165).

[0042] With attention to FTGs. 1, 2, 4-7, gantries (155, 165) are further described. As illustrated in FIG. 4, the first gantry 155 is further described. The first arm 110 includes a needle housing 220 attached to the first arm 110. Alternatively, the needle housing 220 is attached to the gantry 155, or a combination of the first arm 110 and the gantry 155. The needles 185 extend from the housing 220 as described, with the openings 200 positioned towards the base 140 and or the receptacles 190A, See FIG. 2. The needles are attached to, or mounted to, or positioned through one or all of the housing 220, the first arm 110, and the gantry 155. In a first aspect of the needle mountings, the first arm 110 and / or gantry 155 has four needles extending from the one or all of the housing 220, the first arm 110, and the gantry 155. As illustrated in FIGs 2 and 4, the opening 195 of the receptacle 190A and needles 185 are positioned such that each needle 185 enters a separate opening when the needles 185 are lowered into the openings. In a first aspect of the needle mountings, the first arm 110 and / or gantry 155 has four needles extending from the one or all of the housing 220, the first arm 110, and the gantry 155. Alternatively, thefirst arm 110 and / or gantry 155 may have less than four needles extending from the one or all of the housing 220, the first arm 110, and the gantry 155. Alternatively, the first arm 110 and / or gantry 155 may have more than four needles extending from the one or all of the housing 220, the first arm 110, and the gantry 155.

[0043] Each needle, or a combination of needles 185, has a port 225 fluidly attached to the one or all of the housing 220, the first arm 110, and the gantry 155. The port 225 is fluidly connected to a tube 230, see FIG. 9. Thus, fluid to be collected, processed, and prepared for testing by the sampler 100 passes from a fluid source container 235, See FIG. 9, into the tube 230. The fluid passes through the tube 230 and through the port 225. The fluid then passes through all or part of one of all of the housing 220, the first arm 110, and the gantry 155. The fluid then passes in the needle 185 and is deposited in one or more cavities of the receptacle 190A. With that, at least one fluid flow sensor 245 is positioned on one or more of the gantry 155, the first arm 110, and the housing 220. The sensor 245 monitors the amount of fluid passing from a fluid source container 235 through a respective needle 185 and to a respective cavity in the receptacle 190A in which the cavity is present. This sensor 245 is a benefit over the art in that the sensor allows for exact measured of amount of fluid to be placed in a respective cavity of the receptacle 190A. Additionally, the sensor allows for monitoring whether fluid is unable to pass from the container 235 and through the tube 230. Further, each sensor coupled to a respective needle provides an affirmation that fluid is present in all needles prior to transfer to a respective cavity in the receptacle (190,190A). A vacuum or release valve ensures the fluid is maintained in the tube and / or needle prior to placement of the fluid in the respective cavity in the receptacle (190, 190A).

[0044] The gantry 155 has a mounting for the first arm 110 to slidably attach to the gantry 155. For example, the gantry 155 may have two substantially horizontal openings 240 extended along a surface of the gantry 155. The openings 240 are positioned to allow lateral movement of the first arm 110 along the width 135. The gantry may have more or less than two openings 240.

[0045] An illustrated in FIG. 5, the second gantry 165 is further described. The second arm 115 includes a needle housing 220 attached to the second arm 115. Alternatively, the needle housing 220 is attached to the gantry 165, or a combination of the second arm 115 and the gantry165. A needle 185 extends from the housing 220 as described, with the opening 200 positioned towards the base 140 and or the receptacles 190B, see FIG. 2. The needle is attached to, or mounted to, or positioned through one or all of the housing 220, the second arm 115, and the gantry 165. As illustrated in FIGs 2 and 5, the opening 195 of the receptacle 190B and needle 185 are positioned such that the needle 185 enters a respective opening 195 when the needle 185 is lowered into a respective opening. More than one needle 185 may be coupled as described.

[0046] The needles 185 has a port 225 fluidly attached to the one or all of the housing 220, the first arm 110, and the gantry 155. The port 225 is fluidly connected to a tube 230. Thus, fluid positioned in a cavity of the receptacle 195B is transported as follows. The needle enters the cavity of the receptacle 190B. Fluid then passes into the needle 185. The fluid then passes through all or part of one of all of the housing 220, the second arm 115, and the gantry 165. The fluid passes through the port 225 and into the tube 230. The fluid then passes into the tube 230 which is fluidly connected as described. The fluid transfers through the tube 230 to a testing apparatus 250, See FIG. 11. With that, a fluid flow sensor 245 is positioned on one or more of the gantry 165, the second arm 115, and the housing 220. The sensor 245 monitors the amount of fluid passing from a from the cavity of the receptacle 190B to a respective testing apparatus 250. This sensor 245 is a benefit over the art in that the sensor allows for exact measured of amount of fluid to be placed in a respective testing apparatus 250. Additionally, the sensor, based upon positioning of the sensor, may allow for monitoring whether fluid is unable to pass from the cavity of the receptacle 190B and through the tube 230.

[0047] The gantry 165 has a mounting for the second arm 115 to slidably attach to the gantry 165. For example, the gantry 165 may have two substantially horizontal openings 240 extended along a surface of the gantry 155. The openings 240 are positioned to allow lateral movement of the second arm 115 along the width 135. The gantry may have more or less than two openings 240.

[0048] As illustrated in FIGs. 6 and 7, the relationship between the arm (110, 115) and the gantry (155, 165) is further described. The arm (110, 115) has a motive member 255 extending from the arm (110, 115) through at least one opening 240. This motive member 255 is part of and / or attached to a drive mechanism 210 for the arm (110, 115), See FIG. 7. Along a length ofthe respective opening, a seal 260 is positioned. The seal comprises two substantially horizontal members. The seal 260 is made of a rubber, elastomeric material, a polymer or a metal. The seal 260 comprises two members spaced apparat along the length of the opening 240. The seal members of the seal 260 are positioned within the opening 240 to have a spacing 270 between the seal members of the seal 260 along the length of the opening 240. This spacing 270 of the seal members provides for a friction fit of the motive member 255 with the seal members of the seal 260. This spacing allows for the motive member 255 to pass beyond the seal 260 and into a gantry cavity 265, and allows for the motive member to move along the length of the opening 240. This movement of the motive member 255 in turn moves the arm (110, 115) along the opening 240. The seal 260 provides for an improved working condition for the sampler 100. Specifically, the seal prevents foreign objects, for example dust, moisture, dirt, and fluid, from entering the gentry cavity 265. Therefore, the operation of the gentry (155, 165) is optimized over operations of samplers of the prior art for the gantry has an increased operation time over samplers of the prior art.

[0049] For example, a first sealing member 260A may be positioned on a first side of the gantry opening 240 and a second sealing member 260B positioned on a second side of the gantry opening 240. The first and second sides may correspond to an upper and a lower side of the gantry opening 240. For example, one or both of the first sealing member 260A and the second sealing member 260B may include a flexible material and includes an aperture, slit, overlapping lips, compliant wiper edge, brush interface, and / or combinations thereof configured to conform around and sealingly engage the motive member 255. Further, the first sealing member 260A and the second sealing member 260B are replaceable and / or removable to facilitate maintenance and / or cleaning. Alternatively, the seal 260 may comprise more or less than two sealing members.

[0050] With attention to FIG. 7, the mechanic of the gantry (155, 165) are described. Similar to the drive mechanism 210 described, movement of the gantry (155, 165) is provided by a gantry drive mechanism 210. The drive mechanism 210 is attached to the respective arm (110, 115) via the motive member 255. The drive mechanism 210 moves the motive member 255 and the respective arm (110, 115) as previously described. The drive mechanism 210 may be any type of motor, drive, or chain driven system, for example the drive mechanism 210 may includea chain 215 attached to the drive mechanism 210. The seal 260 prevents foreign objects, for example dust, moisture, dirt, and fluid, from entering the gentry cavity 265 and contacting the drive mechanism 210 and other components, such as the chain 215, associated with the drive mechanism.

[0051] A “gantry” may refer to any supporting structure that provides controlled positioning of one or more movable components, including an arm, carriage, head, or end effector, relative to one or more targets such as a fractional collector, plate rack, well plate, vial, and / or analytical instrument. In various embodiments, the gantry includes one or more rails, tracks, guides, bearings, lead screws, belts, cables, limit switch, positioning sensors, and / or linear motors, and one or more actuators such as stepper motors, servo motors, and / or pneumatic actuators to provide motion in one or more degrees of freedom. In various embodiments, the gantry provides motion along one or more orthogonal axes and / or provides rotary motion about one or more axes.

[0052] With attention to FIGs. 1-9, the operation of the apparatus is further described. This operation is performed and controlled by a system and absent or with minimal operator interface. In operation, the first arm 110 receives fluid from a fluid source container 235, See FIG. 9. The container may be for example a reactor vessel. In doing so the fluid transfers through a tube 230 from container 235, see FIG. 9. The tube 230, connect to the first arm 110 as described, transfers the fluid past a sensor 245. The sensor detects the flow of the fluid, and thus the amount of fluid transferring from the containers 235. Specifically, and additionally, each sensor coupled to a respective needle provides an affirmation that fluid is present in all needles prior to transfer to a respective cavity in the receptacle 190. The sensor additionally monitors the rate of transfer of the fluid within the respective tube 230 and needle 185. The fluid travels through a needle 185 as described and into a cavity of the receptacle 190A. Thus, the sensor 245 for a specific tube / container / cand cavity of the receptacle 190A combination provides the quantity of liquid transferred into the specific cavity of the receptacle 190A.

[0053] The fluid may then be transferred by the first arm 110 to a storage. Alternatively, the second arm 115 and gantry 165 advances to the respective cavity of the receptacle 190 A. The second arm 115 advances the needle 185 of the second arm into the respective cavity of thereceptacle that contains the fluid. The needle 185 retrieves an amount of the fluid and transfer the fluid to a cavity in the second receptacle 190B. Alternatively, the first arm 110 and needle 185 of the first am 110 may transfer the fluid to a cavity of the second receptacle 190B.

[0054] The fluid now housed in cavity of the second receptacle 190B may be subject to dilutants or reagents. The apparatus houses dilutants for diluting the fluid. The apparatus houses reagents for reacting with the fluid. Alternatively, the respective dilutants and reagents are housed outside the apparatus 100 and fluidly connected to the apparatus. Dilutants and reagents may be added for preparations of a fluid for testing of the fluid. Alternatively, the fluid may remain in the cavity of the first receptacle 190A. The second arm 115 may transfer a dilutant or reagent to the fluid housed in the cavity of the first receptacle 190A. The fluid is then transferred to a cavity of the second receptacle 190B as described, or by the first arm 110. The fluid is then transferred into the needle of the second arm 115. The fluid passes a sensor 245 as described. The fluid is transferred to an analytical testing device 250 for testing of the fluid. The first arm may also add dilutant(s) and / or reagent(s) to the portion of collected sample in the second well plate. The dilutant(s) and / or reagent(s) may be provided or collected by the first arm from a multi-position valve. The second arm may also be used to mix the fluid transferred to either receptacle (190A, 190B) and any dilutant(s) and / or reagent(s). Alternatively, the first arm may also be used to mix the fluid transferred to either receptacle (190A, 190B) and any dilutant(s) and / or reagent(s). Cleaning solution may be delivered to or through the apparatus using a multiposition valve.

[0055] With attention to FIGs. 8-14, the benefit of multiple collection streams as provided by the invention is further described. As noted, the limitation of the art is one collection is conducted subsequently one after the other. Multiple collection, processing / preparation and storage / testing is not possible. However, the invention for an improvement to the process of collection, processing or preparation, and storage / testing of fluid. As illustrated in FIGs. 8 and 11, the first arm 110 may comprise or have multiple needles. With that, as illustrated in FIG. 8 the first arm 110 may comprise 16 needles 185. Each needle of the multiple needles 185 provided on the first arm 110 is fluidly connected to a separate fluid source container 235. Each fluid transfer for each respective container 235 is monitored by a separate, or the same or combination thereof, sensor 245. As a result, a first fluid from a first container 235 A, forexample having a first metabolite concentration, may be collected into a first cavity of the receptacle 190A. At the same or proximate time, a second fluid from a second container 235B, for example having a second metabolite concentration, which is deposited into a second cavity of the receptacle 190A. Metabolite concentration is the amount of a respective metabolite(s) present in the fluid, for example a biological sample. A metabolite concentration may provide understanding of the cellular metabolism and function as to the fluid. Metabollites are for example small molecules. Further, with multiple collection streamers as described, multiple samples can be taken at the same time and under the same conditions. With that fluctuations fluids, for example but not limited to fluctuations in metabolite concentration and / or temperature, collected is minimized because of the close proximity in time the respective samples are collected. Further, the sampler may control temperature of the receptacles thus controlling the temperature of the fluid within the receptacles. The apparatus 100 may control the temperature of the apparatus 100 and samp les by individually controlling the temperature of respective cavities in the receptacles (190 A, 190B). The fluid may be cooled, chilled, frozen (or warmed) or maintained at temperature as desired to prevent composition changes and / or help preserve sample integrity over time. As illustrated, in FIG. 14, the mechanism for providing multiple sample collections can be a unitary part. Instead of having the sensors separated from the housing 220. The sensors 245 and housing 220 may be combined in a single planar structure extending the width of, or substantially the width of, the receptacle 190A to be filled. This allows for more precise and confined application of the apparatus 100. It is noted, a container 235 may be one or a combination of from one or more reactors, vessels, containers or other process streams to the fractional collector.

[0056] As illustrated in FIG. 11, upon collection and processing / preparation of multiple fluid samples and described. The second arm 115 transfers each respective sample in each respective cavity of the receptacle 190B to a testing apparatus 250. Thus, a first fluid sample in a first cavity of the receptacle is transferred to a first testing apparatus based upon input received. A second fluid sample from a second cavity of the receptacle 190B is transferred to a second testing apparatus for a second test based upon input to the apparatus 100. The first test and the second test may or may not be similar. The order of sample delivery as described is a representative example, and orders of such may have any combination.

[0057] With attention to FIGs 5, 10, and 11, a first aspects of a pump 275 is described. The pump 275 is an external pump 275A. The second gantry 165 and / or second arm 115 are fluidly connected to the external pump 275. The external pump 275A fluidly distributes the fluid samples to the respective testing apparatuses 250 as previously described. With attention to FIG.12, a second aspect of the pump (275, 275B) is described. The pump 275B and the pump 275A have at least one feature of the other respective pump (275A, 275B). The pump 275B is coupled and fluidly connected to one or both of the second gantry 265 and the second arm 115. As a result, fluid is transferred to multiple testers 250 as previously described. The benefit of the pump 275B includes a reduced footprint for a collection and processing of fluid. The pump 275B may contain a muti -position valve. The apparatus 100 may include a motor (e.g., a stepper motor) for rotating or adjusting the needle and / or multi-position valve. The multi-position valve may be disposable to reduce cleaning requirements for that valve and the apparatus including the valve. The apparatus may include a way of receiving data from one or more analytical devices and communicating that data, or other commands based on that data, to a control system. The pump comprises one or more of a positive displacement pump, a peristaltic pump, a diaphragm pump, a needle pump, a piezo pump, and a vacuum pump,

[0058] With attention to FIG. 13, a system illustrating the integration of the apparatus into a controller 280 and an external system 285 is described. The external system 285 comprises various components. These components are, for example, but not limited to, at least one of the following a controller 280, the container 235, and the analytic testing device 250. The controller is configured to receive data from an electrical connection 290 between the controller and the analytical testing device 250. The data may be regarding the fluid tested. The controller communicates the data to the external system. In addition, the control communicates commands to components of the system including the apparatus 100 and the container 235. The external system comprises a control system which controls the transfer of the fluid from the container. The control system additioOnally controls the transfer of fluid within the apparatus, for example the movement of the fluid from the second arm to the analytical device. Thus, the control system controls the transfer of fluid in a process stream, a system feed and a system process. The control is based at least in part on the data, for example data from the analytical tester. The external system comprises a historian, and the controller is configured to communicate the data to the historian. The historian is a database which allows for saving and retrieving of data. With that,the controller is configured to communicate with and / or be accessed through a web portal (290, 290A) comprising a cloud based portal. Further, application of dilutions and reagents to the apparatus are performed automatically through interaction of the apparatus with the controller 280 and the external system 285.

[0059] With attention to FIGs. 1-15, a second aspect of the apparatus 100A is described. The second aspect of the apparatus comprises at least one feature of the first aspect of the apparatus 100. The Second aspect of the apparatus 100A integrates with the container 235, analytical testing device 250, pump 275, controller 280, and external system 285 with the same features and, functionalities, and aspects as the apparatus 100.

[0060] The invention disclosed is to an apparatus to collect multiple samples at the same time or within close proximity of time to one another is provided. The apparatus has the capability to collect samples from one or more material sources, for example: reactors, vessels, containers, and process streams. Accordingly, the apparatus can store samples from one or more material sources. With that, the apparatus can access such multiple samples so that the multiple samples can be tested and / or retested without necessarily acquiring additional samples. The apparatus is capable of sample preparation. The apparatus does sample auto dilutions. Further, the apparatus is capable of communicating with and / or control external analytical instruments. Additionally, the apparatus is capable of obtaining data from such instruments. The apparatus is capable of controlling the amount of sample delivered from a material source. The apparatus is capable of controlling the process applied in the material source based on analytical data.Further, the apparatus is capable of communicating analytical data to a control system and a historian. Therefore, the apparatus provides multiple contemporaneous samples to be taken. The apparatus provides contemporaneous proration of samples for testing. Thus, the apparatus addresses the need to ensure multiple samples are collected, stored, and tested under the same conditions. Therefore, the apparatus ensures comparison of contemporaneous samples, samples collected, prepared and stored under the same conditions.

[0061] As utilized herein, the terms “approximately,” “about,” “substantially”, and similar terms are intended to have a broad meaning in harmony with the common and accepted usage by those of ordinary skill in the art to which the subject matter of this disclosure pertains. It shouldbe understood by those of skill in the art who review this disclosure that these terms are intended to allow a description of certain features described and claimed without restricting the scope of these features to the precise numerical ranges provided. Accordingly, these terms should be interpreted as indicating that insubstantial or inconsequential modifications or alterations of the subject matter described and claimed are considered to be within the scope of the invention as recited in the appended claims.

[0062] It should be noted that references to relative positions (e.g., “top” and “bottom”) in this description are merely used to identify various elements as are oriented in the Figures. It should be recognized that the orientation of particular components may vary greatly depending on the application in which they are used.

[0063] For the purpose of this disclosure, the term “coupled” means the joining of two members directly or indirectly to one another. Such joining may be stationary in nature or moveable in nature. Such joining may be achieved with the two members or the two members and any additional intermediate members being integrally formed as a single unitary body with one another or with the two members or the two members and any additional intermediate members being attached to one another. Such joining may be permanent in nature or may be removable or releasable in nature.

[0064] It is also important to note that the construction and arrangement of the system, methods, and devices as shown in the various examples of embodiments is illustrative only. Although only a few embodiments have been described in detail in this disclosure, those skilled in the art who review this disclosure will readily appreciate that many modifications are possible (e.g., variations in sizes, dimensions, structures, shapes and proportions of the various elements, values of parameters, mounting arrangements, use of materials, colors, orientations, etc.) without materially departing from the novel teachings and advantages of the subject matter recited. For example, elements shown as integrally formed may be constructed of multiple parts or elements show as multiple parts may be integrally formed, the operation of the interfaces may be reversed or otherwise varied, the length or width of the structures and / or members or connector or other elements of the system may be varied, the nature or number of adjustment positions provided between the elements may be varied (e.g. by variations in the number of engagement slots or sizeof the engagement slots or type of engagement). The order or sequence of any process or method steps may be varied or re-sequenced according to alternative embodiments. Other substitutions, modifications, changes and omissions may be made in the design, operating conditions and arrangement of the various examples of embodiments without departing from the spirit or scope of the present inventions.

[0065] Elements shown as integrally formed may be constructed of multiple parts or elements show as multiple parts may be integrally formed, the operation of the interfaces may be reversed or otherwise varied, the length or width of the structures and / or members or connector or other elements of the system may be varied, the nature or number of adjustment positions provided between the elements may be varied (e.g. by variations in the number of engagement slots or size of the engagement slots or type of engagement). The order or sequence of any process or method steps may be varied or re-sequenced according to alternative embodiments. Other substitutions, modifications, changes, and omissions may be made in the design, operating conditions, and arrangement of the various examples of embodiments without departing from the spirit or scope of the invention.

[0066] While this invention has been described in conjunction with the examples of embodiments outlined above, various alternatives, modifications, variations, improvements and / or substantial equivalents, whether known or that are or may be presently foreseen, may become apparent to those having at least ordinary skill in the art. Accordingly, the examples of embodiments of the invention, as set forth above, are intended to be illustrative, not limiting. Various changes may be made without departing from the spirit or scope of the invention.Therefore, the invention is intended to embrace all known or earlier developed alternatives, modifications, variations, improvements, and / or substantial equivalents.

[0067] The technical effects and technical problems in the specification are exemplary and are not limiting. It should be noted that the embodiments described in the specification may have other technical effects and can solve other technical problems.

[0068] Some of the systems, components, and / or processes described above can be realized in hardware or a combination of hardware and software and can be realized in a centralized fashion in one processing system or in a distributed fashion where different elements are spreadacross several interconnected processing systems. Any kind of processing system or another apparatus adapted for carrying out the methods described herein is suited. A typical combination of hardware and software can be a processing system with computer-usable program code that, when being loaded and executed, controls the processing system such that it carries out the methods described herein. Some of the systems, components and / or processes also can be embedded in a computer-readable storage, such as a computer program product or other data programs storage device, readable by a machine, tangibly embodying a program of instructions executable by the machine to perform methods and processes described herein. These elements also can be embedded in an application product which comprises all the maintenance conditions enabling the implementation of the methods described herein and which, when loaded in a processing system, is able to carry out these methods.

[0069] Furthermore, some arrangements described herein may take the form of a computer program product embodied in one or more computer-readable media having computer-readable program code embodied, e.g., stored, thereon. Any combination of one or more computer-readable media may be utilized. The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. The phrase “computer-readable storage medium” means a non-transitory storage medium. A computer-readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, semiconductor system, apparatus, or device, or a suitable combination of the foregoing. More specific examples (a non-exhaustive list) of the computer-readable storage medium would include the following: a portable computer diskette, a hard disk drive (HDD), a solid-state drive (SSD), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a portable compact disc read-only memory (CD-ROM), a digital versatile disc (DVD), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing. In the context of this document, a computer-readable storage medium may be any tangible medium that can contain or store a program for use by or in connection with an instruction execution system, apparatus, or device.

[0070] Program code embodied on a computer-readable medium may be transmitted using an appropriate medium, including but not limited to wireless, wireline, optical fiber, cable, RF, etc., or any suitable combination of the foregoing. Computer program code for carrying outoperations for aspects of the present arrangements may be written in any combination of one or more programming languages, including an object-oriented programming language such as Java™, Smalltalk, C++ or the like and conventional procedural programming languages, such as the “C” programming language or similar programming languages. Program code may be executed entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer, or entirely on the remote computer or server.

[0071] While this invention has been described in conjunction with the examples of embodiments outlined above, various alternatives, modifications, variations, improvements and / or substantial equivalents, whether known or that are or may be presently foreseen, may become apparent to those having at least ordinary skill in the art. Accordingly, the examples of embodiments of the invention, as set forth above, are intended to be illustrative, not limiting. Various changes may be made without departing from the spirit or scope of the invention.Therefore, the invention is intended to embrace all known or earlier developed alternatives, modifications, variations, improvements and / or substantial equivalents.

Claims

CLAIMSWhat is claimed is:

1. An apparatus for fractional sample collection and distribution, comprising:a sampler configured to be in fluid communication with one or more fluid source containers having a fluid;the sampler having a first arm configured to direct the fluid to a sample retaining receptacle coupled to the sampler;the sampler having a second arm configured to be in fluid communication with the sample retaining receptacle; andthe second arm in fluid communication with an analytical device; anda controller electrically coupled to one or more of the sampler and the analytical device with the controller having an instruction for movement of the fluid from the second arm to the analytical device, with the controller electrically coupled to an external system.

2. The apparatus of claim 1, wherein the controller is configured to receive a data from the analytical device as to the fluid and to communicate one or more of the data and a command to the external system.

3. The apparatus of claims 1 or 2, wherein the external system comprises a control system configured to control a fluid transfer from one or more of a reactor, the movement of the fluid from the second arm to the analytical device, a process stream, a system feed and a system process based at least in part on the data.

4. The apparatus of one of claims 1-3, wherein the external system comprises a historian, and the controller is configured to communicate the data to the historian.

5. The apparatus of one of claims 1-4, wherein the controller is configured to communicate with and / or be accessed through a web portal comprising a cloud based portal.

6. The apparatus of one of claims 1-5, further comprising a temperature control system configured to direct a temperature of one or both of the sampler and the fluid.

7. The apparatus of one of claims 1-6, wherein the sample retaining receptacle are one or more well plates or vial racks positioned on a base of the sampler, with a first well plate or vial rack configured for a retention of the fluid and a second well plate or vial rack configured for a second retention of the fluid as process samples, with the first well plate and the second well plate are adjoining, with one or more of the one or more well plates and vial racks being temperature controlled.

8. The apparatus of one of claims 1-7, wherein the sample retaining receptacle has a disposable component.

9. The apparatus of one of claims 1-8, wherein one or both of the first arm and the second arm may is a transporter of a predetermined amount of the fluid from the sample retaining receptacle to a second sample retaining receptacle, with the second arm having an addition of one or more of a dilutant and a reagent to the second sample retaining receptacle.

10. The apparatus of one of claims 1-9, further comprising a multi-position valve fluidly coupled to the second arm, with the multi-position valve and configured to have one or more of a dilutant, a reagent, a waste receptacle, and a cleaning solution.

11. The apparatus of one of claims 1-10, further comprising a motor rotatably coupled one or both of a multi-position valve and a needle coupled to the multi-position valve, with the multiposition valve being a disposable multi-position valve.

12. The apparatus of one of claim 1-11, wherein the first arm having a plurality of needles for a transfer of the fluid from the one or more fluid source containers, with an analytical device being a plurality of analytical devices and a sampling retaining receptacle being a plurality of sampling retaining receptacles, with the one or more fluid source containers are one or more of reactors, vessels, process streamers, and containers.

13. The apparatus of one of claims 1-12, wherein one or both of the first arm and the second arm in fluid connection with at least one sensor, with the at least one sensor have a monitor to the first arm and at least one second sensor having a second monitor from the second arm.

14. The apparatus of one of claims 1-13, wherein the second arm operatively connected to a pump, with the pump comprising one or more of a positive displacement pump, a peristaltic pump, a diaphragm pump, a needle pump, a piezo pump, and a vacuum pump, with the pump being one or more of integrated into the second arm and positioned external to the second arm.

15. The apparatus of one of claims 1-14, further comprising one or more of a dilution device and a reagent delivery device configured to have one or both of a dilutant and a reagent addition to the fluid.

16. The apparatus of one of claims 1-15, further comprising one or both of the first arm and the second arm having a gantry, the gantry having a seal at an operation opening, with the seal having a first sealing member and a second sealing member positioned substantially parallel to one another along a length of the operational opening, with the first sealing member and the second sealing member configured to engage a moving component of the gantry.

17. An apparatus for fractional sample collection and distribution, comprising:a sampler configured to be in fluid communication with one or more fluid source containers having a fluid;the sampler having a first arm configured to direct the fluid to a sample retaining receptacle coupled to the sampler;the sampler having a second arm configured to be in fluid communication with the sample retaining receptacle; andthe second arm in fluid communication with an analytical device; and deliver the fluid to one or more analytical devices;the first arm being a first gantry and the second arm being a second gantry separate from the first gantry, with the first gantry and the second gantry moving along a frame; anda controller electrically coupled to one or more of the sampler and the analytical device with the controller having and instruction for movement of the fluid from the second arm to the analytical device, with the controller electrically coupled to an external system.

18. The apparatus of claim 17, wherein one or both of the first gantry and the second gantry has a seal at an operation opening, with the seal having a first sealing member and a secondsealing member positioned substantially parallel to one another along a length of the operational opening, with the first sealing member and the second sealing member configured to engage a moving component of the respective gantry.

19. The apparatus of claims 17 or 18, wherein the controller is configured to receive a data from the analytical device as to the fluid and to communicate one or more of the data and a command to the external system, with the external system comprising a control system configured to control one or more of a reactor, the movement of the fluid from the second arm to the analytical device, a process stream, a system feed and a system process based at least in part on the data.

20. The apparatus of one of claims 17-19, further comprising a temperature control system configured to direct a temperature of one or both of the sampler and the fluid.

21. The apparatus of one of claims 17-20, wherein the second arm operatively connected to a pump, with the pump comprising one or more of a positive displacement pump, a peristaltic pump, a diaphragm pump, a needle pump, a piezo pump, and a vacuum pump, with the pump being one or more of integrated into the second arm and positioned external to the second arm.

22. The apparatus of one of claim 17-21, wherein the first arm having a plurality of needles for a transfer of the fluid from the one or more fluid source containers with an analytical device being a plurality of analytical devices and a sampling retaining receptacle being a plurality of sampling retaining receptacles, with the one or more fluid source containers are one or more of reactors, vessels, process streamers, and containers.

23. The apparatus of one of claims 17-22, wherein one or both of the first arm and the second arm in fluid connection with at least one sensor, with the at least one sensor have a monitor to the first arm and at least one second sensor having a second monitor from the second arm.

24. An apparatus for fractional sample collection and distribution, comprising:a sampler configured to be in fluid communication with one or more fluid source containers having a fluid;the sampler having a first arm configured to direct the fluid to a plurality of sample retaining receptacles coupled to the sampler;the sampler having a second arm configured to be in fluid communication with the sample retaining receptacles, with the first arm being separate from the second arm;the second arm operatively connected to a pump, with the pump being one or more of integrated into the second arm and positioned external to the second arm;the second arm in fluid communication with an analytical device; anda controller electrically coupled to one or more of the sampler and the analytical device with the controller having and instruction for movement of the fluid from the second arm to the analytical device, with the controller electrically coupled to an external system.

25. The apparatus of claim 24, wherein the pump comprises one or more of a positive displacement pump, a peristaltic pump, a diaphragm pump, a piezo pump, a needle pump, and a vacuum pump.

26. The apparatus of claims 24 or 25, wherein the controller is configured to receive a data from the analytical device as to the fluid and to communicate one or more of the data and a command to the external system.

27. The apparatus of one of claims 24-26, wherein the external system comprises a control system configured to control one or more of a reactor, the movement of the fluid from the second arm to the analytical device, a process stream, a system feed and a system process based at least in part on a data, with the external system having a historian, and the controller is configured to communicate the data to the historian.

28. The apparatus of one of claims 24-27, wherein the controller is configured to communicate with and / or be accessed through a web portal comprising a cloud based portal.

29. The apparatus of one of claims 24-28, further comprising a temperature control system configured to direct a temperature of one or both of the sampler and the fluid.

30. The apparatus of one of claims 24-29, wherein the sample retaining receptacle are one or more well plates or vial racks positioned on a base of the sampler, with a first well plate configured for a retention of the fluid and a second well plate configured for a second retention of the fluid as process samples, with the first well plate and the second well plate are adjoining, with one or more of the one or more well plates and vial racks being temperature controlled.

31. The apparatus of one of claims 24-30, wherein the one or more retaining receptacles have a disposable component.

32. The apparatus of one of claims 24-31, wherein the first arm is a transporter of a predetermined amount of the fluid from the sample retaining receptacle to a sample second retaining receptacle, with one or both of the first arm and the second arm having an addition of one or more of a dilutant and a reagent to one or both of the first and second sample retaining receptacle.

33. The apparatus of one of claims 24-32, further comprising a multi-position valve fluidly coupled to the second arm, with the multi-position valve and configured to have one or more of a dilutant, a reagent, and a cleaning solution, with the multi-position valve being a disposable multi-position valve.

34. The apparatus of one of claims 24-33, further comprising one or more of a dilution device and a reagent delivery device configured to have one or both of a dilutant and a reagent addition to the fluid.

35. The apparatus of one of claims 24-34, further comprising one or both of the first arm and the second arm having a gantry, the gantry having a seal at an operation opening, with the seal having a first sealing member and a second sealing member positioned substantially parallel to one another along a length of the operational opening, with the first sealing member and the second sealing member configured to engage a moving component of the gantry.

36. The apparatus of one of claims 24-35, wherein the one or more fluid source containers are one or more of reactors, vessels, process streamers, and containers.

37. The apparatus of one of claim 24-36, wherein the first arm having a plurality of needles for a transfer of the fluid from the one or more fluid source containers, with an analytical device being a plurality of analytical devices and a sampling retaining receptacle being a plurality of sampling retaining receptacles.

38. The apparatus of one of claims 24-37, wherein one or both of the first arm and the second arm in fluid connection with at least one sensor, with the at least one sensor have a monitor to the first arm and at least one second sensor having a second monitor from the second arm.

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