54results about How to "Avoid early release" patented technology

The present invention discloses a drug sustained and controlled release microparticle preparation for treating intestinal diseases. The preparation comprises: a pill core containing the drug, wherein the pill core contains 5-aminosalicylic acid and an assistant material; an isolation layer for providing a smooth and flat surface for the microparticle and preventing the drug from penetrating into a sustained release coating layer, wherein the penetration of the drug into the sustained release coating layer can affect the release effect, the used material of the isolation layer comprises one or a plurality of materials selected from a water-soluble polymer and an anti-adhesion agent; the sustained release coating layer for slowly releasing the drug, wherein different drug release levels can be achieved through adjusting the thickness of the sustained release coating layer, the used material of the sustained release coating layer mainly adopts a sustained-release material; an enteric-coating layer, the enteric-coating layer is provided for avoiding the early release of the drug in gastric juice, reducing stimulation of the main drug to stomach, increasing the local concentration of the drug in the lesion location, the used material of the enteric-coating layer mainly adopts a polymer enteric material. The invention further discloses a preparation method for the microparticle preparation. According to the present invention, the drug and the sustained release coating material are uniformly dispersed on the surface of the pellet, such that the problem of mixing uniformity of the assistant material and the main drug can be effectively solved.

The invention discloses a method for preparing a three-dimensional porous stent composite layer, and belongs to the technical field of biomaterials. In order to prevent inflammatory reaction caused by drop of scraps of a stent due to a dynamic action, a coating film is required on the surface of a porous ceramic stent, and addition of hydroxyapatite powder fills up a voidness defect of the surface layer of the stent so as to improve the strength of the stent; a porous calcium phosphate ceramic stent is compounded by a polylactic acid solution added with hydroxyapatite and a growth factor-loaded hydrogel solution; growth factors loaded in the hydrogel can be slowly released to a human part needing the growth factors under the joint action of own diffusion and slow degradation of polymeric hydrogel so as to promote vascular endothelial growth of a tissue and proliferation and differentiation of an osteoblast; and the stent is gradually degraded and eventually transformed into a bone; and the method is mainly used for preparing the three-dimensional porous stent composite layer.

The invention discloses an ROS-responsive nanoparticle and application thereof in precise tumor treatment mediated by acoustic dynamic. An ROS sensitive molecule TL is utilized to be connected with anantitumor drug PTX and a hydrophilic fragment NH2-PEG1K-NH2 to obtain an amphipathic ROS sensitive fragment PTX-TL-PEG1K-NH2, and then an ultrasonic emulsification method is utilized to obtain the ROS-responsive nanoparticle loaded with a sensitizer IR780; the prepared nanoparticle can generate ROS under the action of external ultrasound to not only kill tumor cells, but also make the nanoparticle release the PTX to kill the tumor cells, thereby forming a cascading amplification synergistic effect during tumor treatment by the acoustic dynamic to achieve precise tumor treatment.

The invention discloses a cross-linked nano-micelle with redox sensitive performance and a preparation method of the cross-linked nano-micelle. The preparation method comprises the following steps: a reversible addition-fragmentation chain transfer polymerization method is adopted, a macromolecular chain transfer agent is synthesized firstly and polymerized with poly(ethylene glycol) methacrylate to synthesize a block polymer which can be further modified, on the basis of self-assembly, a cross-linking agent having chemical linking capacity and containing a disulfide bond is introduced, and one stably cross-linked nano-micelle with the redox response performance is constructed in a mode of assembly and later cross-linking. The method is easy to control, the reaction conditions are mild, a metal catalyst is avoided, a product is easy to purify, and the obtained nano-micelle not only can package a hydrophobic drug but also can prevent the drug from being released in advance in blood circulation.

The invention provides antibody-modified liposome-nanoparticle hybrids (Liposome-nanoparticle hybrids, LNHy) with a lipid shell and a nanoparticle core, which take charged nanoparticles as an inner core, and a liposome phospholipid bilayer with opposite charges is coated onto the surface to form a cell-like structure with a core-shell. The hybrids have targeting ability and can encapsulate an anti-inflammatory drug and an anti-fibrosis drug which have prevention and/or treatment effects on chronic glomerulonephritis, so that the effective treatment effect of double regulation and control on chronic glomerulonephritis is realized.

The invention provides a front-end rear release mechanism of an interventional stent conveyor, a conveyor and a using method. The front-end rear release function of an interventional stent is achieved by arranging a moving claw capable of moving on a first limiting piece in the axial direction on a front-end assembly and connecting the moving claw with a metal block of a rear-end assembly of the conveyor through a drawing wire. The rear end assembly realizes positioning locking and axial movement of a release sleeve and a screw rod through a guide locking mechanism arranged on the release sleeve and the screw rod, so that positioning locking and axial movement of the moving claw on the first limiting piece are realized, and the problem that the interventional stent is released in advance due to the fact that the moving claw is unlocked in advance can be solved; and meanwhile, the problem that the interventional stent cannot be released due to the fact that the moving claw cannot be unlocked can be solved. The guide locking mechanism is designed to be a guide column and an L-shaped guide groove formed in the outer surface of the screw rod, it is guaranteed that the front-end rear release mechanism is safe in self-locking and rapid in unlocking, and the safety, reliability and positioning accuracy of the conveyor are further improved.

The invention provides a preparation method and application of a gold-platinum composite nanometer diagnosis and treatment agent, and relates to a method for obtaining Au2Pt-PEG-PS (PS: photosensitizer) through the steps of synthesizing Au2Pt nanometer particles by using L-proline as a chelating agent and L-ascorbic acid as a reducing agent and performing post modification, and an application of the Au2Pt-PEG-PS (PS: photosensitizer). The Au2Pt-PEG-PS nanometer particles have catalase activity and peroxidase activity, and can react with hydrogen peroxide (H2O2) overexpressed in tumors under the weak acid condition to produce oxygen (O2) and high-toxicity active oxygen hydroxyl radicals (.OH) in situ, so that the effects of overcoming anoxia, strengthening light power effects and killing cancer cells can be achieved. Au2Pt alloy further can realize multimode imaging of CT imaging, photoacoustic imaging, photothermal imaging and the like at the same time, and united treatment and diagnosis and treatment integration are realized.

The invention discloses a preparation method and application of a novel phototherapy nano preparation based on polyhedral oligomeric silsesquioxane (POSS). The phototherapy nano preparation is prepared by forming nano particles by chemical cross-linking reaction between amino of the POSS and carboxyl of a photosensitizer and then performing surface pegylation. The nano preparation has the benefits that the photosensitizer is taken as one part by utilizing a chemical cross-linking method, so that the ultra-high drug loading capacity is realized; the advance drug leakage is avoided; a self-quenching effect of the photosensitizer is inhibited. Meanwhile, the drug has good water dispersibility, stability and biosafety. In addition, the phototherapy nano preparation can be endocytosed by cancer cells in large quantities and efficiently kill the cancer cells under light conditions. An in-vivo animal experiment proves that the phototherapy nano preparation can be enriched to a tumor area through passive targeting, so that tumor imaging and photodynamic therapy are realized.

The invention provides a filter chamber pressure-bearing open-and-close component for a filtering element of a flexible tube squeezer. In the invention, a flexible tube squeezer is high-pressure solid-liquid separation equipment for deep dehydration; and the filter chamber pressure-bearing open-and-close component for the filtering element of the flexible tube squeezer is a component combining a push-pull clamping force balance mechanism with a pressure-applying structure, and the component is related to maintenance of pressure in a filter chamber during the slurry squeezing process and discharge of a filter cake after squeezing. The push-pull clamping force balance mechanism comprises a front swing pressure-bearing plate, a rear swing pressure-bearing plate, an electric actuating mechanism, an upper push-pull cam plate, a lower push-pull cam plate, a traveling mechanism and a horizontal shaft; and by utilizing the component, the filtering element of the flexible tube squeezer can also replace the traditional plate-and-frame diaphragm of a plate-and-frame diaphragm squeezer. The filter chamber pressure-bearing open-and-close component has the advantages of simplified structure, easily controlled sealing pressure, greatly strengthened reliability, lowered manufacturing accuracy and prolonged service life; the component can assist in automatically completing the treatment process and is more beneficial to making big filtering element so as to realize ultra-large-scale treatment; and in addition, the equipment can be loaded on a transport vehicle to form mobile dewatering equipment.

The present invention discloses controlling session timer method in session initiation protocol (SIP) network, said method used in application service server (AS) and backward transaction user (TU) solid system, said backward TU solid configured having session timer. Said method includes A, said AS determining said session timer duration and transmitting to backward TU solid; B, step A mentioned backward TU solid according to received session timer duration to reconfigure own session timer. The present invention also discloses a system. The present invented method and system can reduce temporary responsive repeating transmission.

The invention discloses an endoscope double-arm closing clamp for closing a digestive tract perforation. The closing clamp comprises a releasable clamping head assembly, a connecting block and a releasing assembly. Through the handheld part of an sliding operating handle, a side tong head can be independently controlled, and the clamping head assembly can be released. The closing clamp can processlarge perforation, the tong head can be repeatedly opened and closed, the tong head can be independently controlled, and meanwhile misoperation is prevented.

The invention provides a magnetic field control spiral nano-robot for targeted drug delivery. The nano-robot comprises a spiral carbon nanotube matrix, a polyethylene glycol modification layer, magnetic nano drug-loaded particles and a target cell ligand. The spiral nano robot can achieve multiple functions of magnetic field driving, drug carrying, targeted cell recognition, controllable drug release, fluorescence feedback and the like, lays a foundation for scientific research and clinical treatment of drug delivery, and has potential application prospects in the field of biomedicine.

The invention discloses a hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and a preparation method thereof. The hollow mesoporous organic silicon composite nanomaterial comprises hollow mesoporous organic silicon nanoparticles (HMON) and a drug and a magnetic resonance imaging (MRI) contrast agent, the drug is carried in a cavity of the HMON, and the MRI contrast agent is blocked in a pore channel of the HMON. The hollow mesoporous organic silicon composite nanomaterial can well avoid early release of chemotherapeutic drugs and further improve the drug loading rate. The hollow mesoporous organic silicon composite nano material induces biodegradation to release the medicine loaded in the cavity through GSH response in a tumor microenvironment, so that slow release and controlled release of the chemotherapeutic medicine in the tumor microenvironment are realized, and the toxic and side effects on normal tissue cells are very small while an ideal anti-tumor effect is fully played.

The invention discloses a water-soluble dropping pill prepared from a porous material and a preparation method thereof. According to the water-soluble dropping pill prepared from the porous material, the water-soluble dropping pill comprises an inner layer, a middle layer and an outer layer; the inner layer is formed by loading water-soluble essence on the porous material, the middle layer is a gel layer formed by cross-linking reaction of sodium alginate and calcium salt, and the outer layer is a latex water locking layer formed by curing emulsion. According to the water-soluble dropping pill prepared from the porous material, the inner layer is formed by loading the water-soluble essence on the porous material, and compared with a traditional dropping pill with the inner layer only formed by the water-soluble essence, after the dropping pill is pinched broken, the water-soluble essence cannot directly and rapidly overflow out, the essence component is slowly released under the adsorption effect of the porous material so that the aroma release amount can be maintained in the stable state during the whole cigarette smoking process, and the requirements of consumers on the stable, slow and long-time stable release of the cigarette aroma during the cigarette smoking process can be met.

The invention discloses a multifunctional drug carrier material based on a gold nanocage and a preparation method thereof. The preparation method comprises the following steps: preparing the gold nanocage through an electrochemical replacement reaction between silver nanocubes and chloroauric acid, modifying sulfydryl-polyethylene glycol-amino to the surface of the gold cage by utilizing relatively strong interaction between the gold nanocage and a thiol group, modifying a gemcitabine prodrug responded by glutathione modified by p-nitrophenyl through a chemical reaction, and loading positively charged L-arginine through electrostatic interaction, and finally, wrapping by a tumor cell membrane through a liposome squeezer, so as to obtain the cell membrane-wrapped drug-loaded gold nanocage. The drug carrier disclosed by the invention has multifunctionality, namely multidrug delivery capacity, glutathione-responsive drug release performance, photo-thermal performance, tumor deep penetration effect and tumor targeting, and can be used for combined treatment of pancreatic malignant tumors.

The invention provides a lumen stent which comprises a tubular main body with a plurality of axial planes and a semi-release device connected to the tubular main body, the semi-release device comprises a limiting rod and a plurality of binding lines arranged on the tubular main body, the binding lines are all detachably connected with the limiting rod, and when the binding lines are connected with the limiting rod, the binding lines are separated from the limiting rod. A plurality of binding lines are arranged on the tubular main body, the limiting rods extend along a curve between every two adjacent binding lines, and the limiting rods are located in at least two axial planes on rod bodies of every two adjacent binding lines. The binding lines in the lumen stent circumferentially restrain the lumen stent, so that the lumen stent can be in a semi-release state; therefore, the lumen stent can be adjusted and positioned, and the accuracy of axial and circumferential positioning of the lumen stent is improved.

The invention relates to a medicament for killing Solenopsis invicta, and a preparation method thereof. The medicament comprises, by weight, 0.13-0.24 part of fipronil, 2.5-5.5 parts of an indoxacarb/chitosan sustained-release microsphere, 0.3-0.8 part of a preservative, 1.5-3.5 parts of an adhesive, 30-40 parts of an attractant and 65-85 parts of a carrier; the surface of the indoxacarb/chitosansustained-release microsphere is coated with a layer of degradable film; and the carrier is one or a composition of two or more of wheat flour, sesame powder and corn flour. The preparation method ofthe medicament specifically comprises the following steps: S1, mixing and stirring the carrier and water to form an emulsion, adding active ingredients into the carrier emulsion, performing stirring until uniformity, adding the indoxacarb/chitosan sustained-release microsphere, and performing stirring until uniformity to prepare a mixed emulsion; S2, sequentially adding the adhesive, the attractant and the preservative into the mixed emulsion, and performing stirring until uniformity to prepare a primary medicament product; and S3, carrying out extrusion granulation, cooling and screening treatment on the primary medicament product to prepare the finished medicament finished product. The Solenopsis invicta killing durability of the medicament is improved.