10results about How to "Avoid early release" patented technology

The invention belongs to the field of drug preparation, and particularly relates to a preparation method and application of a drug delivery system based on hollow mesoporous polydopamine nanoparticles. The drug delivery system comprises hollow mesoporous polydopamine nanoparticles, a drug loaded inside and / or outside the hollow mesoporous polydopamine nanoparticles, and pectin wrapping the hollow mesoporous polydopamine nanoparticles, the medicine is a medicine with a nerve protection effect and an acetylcholin esterase inhibitor. The drug delivery system can reduce proinflammatory cytokines, regulate functions of target immune cells, synergistically reduce necrosis of neurons in intestinal tracts and induce neural crest stem cells in the intestinal tracts to be differentiated into neurons.

The present invention relates to the technical field of nanomaterials, and in particular to a drug-loaded mesoporous silica sustained-release system and a preparation method thereof. Firstly, mesoporous silica is prepared by a soft template method, and then the drug is loaded on the mesoporous silica by an impregnation method. Then, the drug-loaded mesoporous silica is coated with chitosan. The prepared drug-loaded mesoporous silica sustained-release system has pH responsiveness, can achieve long-term sustained-release of drugs, and can maximize the therapeutic effect of the drugs.

The invention belongs to the technical field of drug carriers, and particularly discloses a preparation method and application of a closed-loop feedback-regulation nano drug delivery system.The preparation method comprises the following steps that a starting material containing a reversible molecular library is provided, and the reversible molecular library is prepared in a buffer salt system; under thermodynamic control, adding anti-cancer drug molecules and guest molecules into the starting material; through a reversible covalent reaction process, molecules in an initial material spontaneously form a self-assembled nano-carrier containing drug molecules under the combined action of the drug molecules and guest molecules. According to the preparation method and application of the closed-loop feedback-regulation nano drug delivery system, reversible covalent reaction, closed-loop feedback-regulation and self-assembly technologies are combined, spontaneous construction of a nano carrier is achieved, and the nano carrier is endowed with excellent drug loading capacity, stability and environmental responsiveness.

The application relates to a heating element, an atomization device and an aerosol generating system. The heating element comprises: a base body configured to form an atomization channel for accommodating an aerosol generating article; a first heating body arranged at one end of the base body to form a first heating area on a channel wall of the atomization channel, the first heating area being used for heating a medium section; and a second heating body arranged at the other end of the base body to form a second heating area on the channel wall of the atomization channel, the second heating area being arranged adjacent to the first heating area and being used for heating a functional section; wherein the base body is formed of a low-thermal-conductivity material. The heating element can separately control the temperatures of different areas of the base body by using the first heating body and the second heating body, thereby forming a more accurate regional temperature field distribution.

The invention discloses a memory resource management method and device, a storage medium and electronic equipment. The method comprises the steps that in response to starting of a target process, a target interface of the target process is initialized; in response to the received first message sent by the first process, the target reference frequency is increased by a preset value through the target interface, the first process is deployed on the client, the client and the server are set to use the same memory space, and the target reference frequency represents the reference frequency of the target memory resource; the first message is used for indicating that target memory resources need to be used; in response to the received second message, reducing the target reference frequency by a preset value through the target interface, the second message being used for indicating that the target memory resource is used up; and releasing the target memory resource under the condition that the target reference frequency meets a preset condition. The technical problem that the management efficiency of memory resources is low is solved.

The invention provides a biodegradable ammonium persulfate coating gel breaker for fracturing operation and a preparation method of the biodegradable ammonium persulfate coating gel breaker. The preparation method comprises the following steps: determining a mass ratio R of rosin glyceride to ethyl cellulose according to a target reservoir temperature T, and calculating a coating weight gain ratio coefficient K and the total mass of a coating material according to target delayed gel breaking time t; preparing a core material ammonium persulfate into a water phase, and emulsifying in an oil phase to form a reversed-phase microemulsion; a gradient interface deposition method is adopted, a coating solution A prepared from rosin glyceride and part of ethyl cellulose and a coating solution B prepared from the remaining ethyl cellulose are dropwise added in sequence, and a coating material is sequentially deposited on a core material liquid drop interface through pressure reduction to form a compact bottom layer and a slow-release main body layer; according to the invention, the coating layer is biodegradable, chlorine-free and corrosion-free, through the cooperation of the material ratio and the process, the accurate and controllable delay of the gel breaking time at high temperature is realized, the reservoir is effectively protected, and the fracturing effect is improved.

This invention discloses a cement-stabilized crushed stone base course material and its construction process, relating to the fields of road engineering and inorganic binder stabilized materials. It includes a load-bearing component A and a moisture-retaining component B, which are mixed separately and laid sequentially. Based on 100 parts by weight of the total dry mass of crushed stone aggregate and mineral shell water-retaining particles in the load-bearing component A, the load-bearing component A comprises 3.8–5.2 parts by weight of silicate cement and 0.4–1.2 parts by weight of mineral shell water-retaining particles. Based on 100 parts by weight of the total dry mass of crushed stone aggregate and mineral shell water-retaining particles in the moisture-retaining component B, the moisture-retaining component B comprises 3.8–5.2 parts by weight of silicate cement and 1.8–4.0 parts by weight of mineral shell water-retaining particles. By placing a larger amount of internal curing water in the upper part of the base course where evaporation is more significant, and placing only a smaller amount of water-retaining particles required for continuous hydration in the lower part of the base course, the effective utilization rate of internal water storage can be improved.

The utility model relates to a drinking food gas pressure detection device, and belongs to the technical field of gas pressure detection. The device mainly comprises a supporting table, a stand column, a sliding block, a mounting block, a locking bolt, a pressure gauge, a puncture needle, an exhaust valve, a shear type lifting mechanism, a bottle support and a knurled handle. The shear type lifting mechanism and the bottle support are matched to stably fix a beverage bottle at a detection position, carbon dioxide gas in a beverage enters the carbon dioxide containing cavity through the puncture needle for pressure detection, the problem that carbon dioxide is released in advance in a hand-cranking mode is avoided, it is guaranteed that a measurement result is closer to a true value, and the sealing ring guarantees the sealing performance of the device; the surface of the knurled handle is provided with anti-slip lines, so that a worker can conveniently hold the knurled handle by hand to lift the whole device together with the beverage and shake up the carbonated beverage, the carbon dioxide is more fully released, and the detection precision is improved.

This invention discloses an artesunate prodrug, its preparation method, and its application. The artesunate prodrug comprises amphiphilic polymer groups with different functions coupled to a 1,3,5-triazine-2,4,6-triamine or cyanuric chloride backbone molecule as shown in formula (I). The amphiphilic polymer groups are hydrophilic polyethylene glycol derivative groups containing terminal amino or carboxyl groups and artesunate groups. This artesunate prodrug can self-assemble into long-acting liposomes in water, showing potential for treating neutrophilic asthma.

The application discloses a kind of concrete internal curing agent for high-temperature underground chamber and its preparation method, belong to concrete material technical field.The internal curing agent is composed of sealing film liquid and superabsorbent polymer, sealing film liquid is compounded by epoxy modified polyurethane emulsion, nano silicon dioxide, carboxyl-containing acrylate copolymer, temperature-sensitive polyether polyol and coupling agent in proportion, form the core-shell structure with sealing film liquid as shell, SAP as core, with good high-temperature resistance and alkali resistance.The internal curing agent does not affect the working performance of concrete, in the high-temperature environment of 30~90 DEG C, when the hydration process of cement causes the pH value of pore solution in concrete to rise, the temperature of concrete rises and internal water shortage occurs, sealing film gradually ruptures under the synergistic effect of high temperature and high alkali, releases the water stored by SAP, provides the required free water for the continuous hydration of cement in concrete, effectively improves the strength and durability of concrete under high-temperature conditions.