This utility model provides a disposable ultrasonically welded anti-theft packaging box, relating to the field of packaging box technology. The disposable ultrasonically welded anti-theft packaging box includes a box body and a box lid. The top of the box body is open, and the box lid is placed on top of the box body and ultrasonically welded to the box body. The box lid includes a cover body and a sealing piece. The cover body has an opening that extends through the axial direction. The edge of the sealing piece is connected to the cover body and blocks the opening. At least one edge of the sealing piece is provided with an easy-tear structure. The box body and box lid of this utility model are ultrasonically welded, which on the one hand provides a firm connection and a significant packaging effect. On the other hand, in conjunction with the easy-tear structure of the box lid, items can be extracted by destructively disassembling the sealing piece of the box lid. Not only is the extraction of items convenient, but it is also irreversible. Once extracted, the item is permanently destroyed, resulting in a significant anti-theft effect.