This invention belongs to the interdisciplinary field of
biomedical engineering and
artificial intelligence-assisted diagnosis. It discloses a training method for a SERS spectral classification prediction model and its application. The disclosed SERS spectral classification prediction model training method combines CatBoost
feature selection and
deep learning. First, surface-enhanced
Raman spectroscopy (SERS) data of serum from different categories of subjects is collected. After baseline removal, filtering, and normalization preprocessing, CatBoost
gradient boosting algorithm is used to evaluate feature importance, considering the high-dimensional redundancy of the
spectral data, and to select a subset of discrete feature bands containing key biomarker information. This feature subset is then input into a one-dimensional
convolutional neural network model for training. The model constructed by this invention possesses deep
feature mining capabilities, and the biological
interpretability of the decisions is verified through SHAP analysis. It effectively solves the problems of large
spectral noise interference and difficulty in extracting weak
pathological features in traditional methods. For example, it can be used for the auxiliary diagnosis of
coronary heart disease, achieving non-invasive, rapid, and high-precision classification and diagnosis of
coronary heart disease and its subtypes.