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Marker molecule for predicting sensitivity of patient to preoperative chemoradiotherapy and surgical mesorectal resection and derivative product of marker molecule

A technique of radiotherapy, chemotherapy and resection, applied in a specific field, can solve problems such as unpredictable sensitivity and achieve good diagnostic efficiency

Inactive Publication Date: 2021-12-28
QINGDAO MEDINTELL BIOMEDICAL CO LTD
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Problems solved by technology

[0005] Although preoperative chemoradiotherapy combined with total mesorectal resection is the standard method for the treatment of patients with locally advanced rectal cancer, it is still difficult to predict which rectal cancer patients will be sensitive to the above combined therapy and predict the sensitivity of rectal cancer patients to treatment. Responsiveness or responsiveness remains a great challenge, therefore, the discovery of biomarkers that can be used to accurately predict the sensitivity of rectal cancer to preoperative chemoradiotherapy combined with total mesorectal resection, and its application to preoperative treatment-sensitive It is of great importance to the field in the screening of rectal cancer patients

Method used

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  • Marker molecule for predicting sensitivity of patient to preoperative chemoradiotherapy and surgical mesorectal resection and derivative product of marker molecule
  • Marker molecule for predicting sensitivity of patient to preoperative chemoradiotherapy and surgical mesorectal resection and derivative product of marker molecule
  • Marker molecule for predicting sensitivity of patient to preoperative chemoradiotherapy and surgical mesorectal resection and derivative product of marker molecule

Examples

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Embodiment 2

[0097] Example 2 Verification of the diagnostic efficacy of genes PDGFRA, CTDP1, and AGR2 in predicting the sensitivity of rectal cancer patients to preoperative chemoradiotherapy combined with total mesorectal resection

[0098] 1. Experimental method

[0099] For the differentially expressed genes PDGFRA, CTDP1, and AGR2 screened in Example 1 between responders and non-responders, use the R package "pROC" (version 1.15.0) to perform receiver operating characteristic (ROC) analysis, calculate The area under the receiver operating characteristic curve (AUC) was used to evaluate the effect of genes PDGFRA, CTDP1, AGR2, PDGFRA+CTDP1, PDGFRA+AGR2, CTDP1+AGR2, and PDGFRA+CTDP1+AGR2 on the prediction of colorectal cancer patients in the training set and validation set, respectively. Accuracy of preoperative chemoradiotherapy combined with total mesorectal resection for treatment sensitivity, wherein the AUC value ranges from 0 to 1;

[0100] Among them, when judging the diagnostic...

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Abstract

The invention discloses a marker molecule for predicting the sensitivity of a patient to preoperative chemoradiotherapy and surgical mesorectal resection and a derivative product of the marker molecule. The marker molecule is PDGFRA, CTDP1 and / or AGR2; and verification shows that the marker molecule has good diagnostic efficiency for predicting the sensitivity or reactivity of a rectal cancer patient to surgery treatment, and can be widely applied to prediction of the sensitivity of the rectal cancer patient to surgery treatment. The invention further discloses a pharmaceutical composition for improving the sensitivity of the rectal patient to the preoperative chemoradiotherapy and surgical mesorectal resection.

Description

technical field [0001] The present invention belongs to the technical field of biomedicine. Specifically, the present invention relates to marker molecules and derivatives thereof for predicting the sensitivity of patients to preoperative chemoradiotherapy combined with total mesorectal resection. More specifically, the present invention relates to predicting the sensitivity of patients to Marker molecules PDGFRA, CTDP1, and / or AGR2, and their derivatives, that are sensitive to preoperative chemoradiotherapy combined with total mesorectal resection. Background technique [0002] Rectal cancer is one of the most common malignant tumors of the digestive tract, which refers to the cancer between the dentate line and the rectosigmoid junction. Its incidence rate ranks third among malignant tumors in my country, and its mortality rate ranks fifth among malignant tumors in my country. It has the epidemiological characteristics of younger age of onset and higher incidence. Accordi...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G01N33/574A61K45/00A61P35/00G16B25/20G16B30/00G16B50/00G16H50/30
CPCC12Q1/6886G01N33/57484G01N33/57446A61K45/00A61P35/00G16B25/20G16B30/00G16B50/00G16H50/30C12Q2600/106C12Q2600/158
Inventor 杨承刚王丹李雨晨
Owner QINGDAO MEDINTELL BIOMEDICAL CO LTD
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