A glutathione-activated co-assembled nanoprobe and its preparation method and application
By constructing the amphiphilic small molecule probes 1-Zn-PPA and 1-NLG, the limitations of existing tumor diagnosis and treatment probes in imaging and treatment are solved, and accurate tumor imaging and multi-mode treatment are achieved, effectively inhibiting tumor metastasis.
Patent Information
- Application Number
- CN202211142252.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-09-20
- Publication Date
- 2025-08-15
- Estimated Expiration
- 2042-09-20
AI Technical Summary
The existing tumor diagnosis and treatment probes have a single imaging mode in tumor imaging and treatment that is difficult to achieve accurate imaging. A single treatment method has limited ability to treat tumors, especially for recurrent and metastatic tumors.
The amphiphilic small molecule probes 1-Zn-PPA and 1-NLG were constructed, and co-assembled nanoprobes 1-NPs were formed, and the tumor site was aggregated by the tumor EPR effect and the targeting of the probe surface cRGD, and the hydrophilic small molecule containing Gd, the photo/acoustic drug Zn-PPA-SH and the immune adjuvant drug NLG919 were deassembled in the reduction environment of glutathione (GSH), to realize the combined treatment of acoustic dynamic therapy, photodynamic therapy and immunotherapy.
High-resolution and highly sensitive accurate imaging of tumors is achieved, and through the combination of sound-photodynamic therapy and immunotherapy, it effectively inhibits tumor metastasis, reduces the side effects of heavy metal toxicity, and enhances the therapeutic effect.