A method and device for maintaining temperature, hydrogen peroxide gas concentration and saturation

Abstract

The present invention relates to the field of hydrogen peroxide sterilization technology. To address the problem of the lack of a method for simultaneously controlling and maintaining the hydrogen peroxide concentration and relative saturation in a confined space in the prior art for a long period of time, a method and device for maintaining temperature, hydrogen peroxide gas concentration, and saturation are disclosed. The method comprises dehumidifying the confined space, vaporizing a high-concentration hydrogen peroxide solution, and injecting it into the confined space until the difference between the target concentration and the actual concentration in the confined space is less than 50 ppm, then vaporizing a low-concentration hydrogen peroxide solution and injecting it into the confined space until the difference between the actual relative saturation and the target saturation is less than 2%, and then maintaining the concentration and saturation in the confined space by injecting the high-concentration hydrogen peroxide solution and the low-concentration hydrogen peroxide solution, respectively. This method can regulate and maintain the temperature, hydrogen peroxide concentration, and relative saturation in the confined space for a long period of time, with minimal fluctuations in the concentration and relative saturation during control.

Description

Technical Field

[0001] The present invention relates to the technical field of hydrogen peroxide sterilization, and in particular to a method and device for maintaining temperature, hydrogen peroxide gas concentration and saturation. Background Art

[0002] Vaporized hydrogen peroxide (VHP) can be sterilized at room temperature without leaving any residue, and is widely used in many fields. When using VHP sterilization technology for sterilization and disinfection, there are many factors that need to be considered, such as temperature, humidity, relative saturation, hydrogen peroxide gas concentration, sterilization time, gas source, pressure, the object being tested, etc. Among them, temperature and saturation are important parameters besides VHP concentration, and their levels will directly affect the sterilization and disinfection effects and the resistance test results of the object being tested. Most existing research and applications use the concentration of hydrogen peroxide gas as a criterion for determining whether sterilization is successful, while ignoring the role of temperature and saturation in sterilization, and the control of temperature and saturation is relatively arbitrary. For example Filip et al. (2019), in their study of the sterilization effect of vaporized hydrogen peroxide on biological indicators, focused solely on the differences in killing bioindicators at different hydrogen peroxide concentrations, without considering the effects of temperature and saturation. Due to this lack of fundamental research, existing sterilization equipment often relies on extended sterilization times and / or increased VHP sterilization concentrations to ensure sterilization effectiveness. This can easily lead to equipment corrosion and wear within the sterilization environment, as well as unnecessary waste of hydrogen peroxide solution.

[0003] At the same time, most existing studies use biological indicators to verify VHP sterilization efficacy, and there is currently a lack of equipment on the market that can simultaneously control and maintain temperature, VHP concentration, and saturation. For example, Chinese patent CN203021566U discloses a "vaporized hydrogen peroxide sterilization indicator resistance test device." This utility model can only be performed under vacuum conditions and does not further control temperature, saturation, VHP concentration, etc. For another example, U.S. Patent US6936434B2 discloses a "device for evaluating the resistance of a biological indicator." This resistance meter primarily controls temperature, pressure, and flow to achieve and maintain a stable state within the resistance meter chamber, but does not monitor and / or control the sterilant concentration and saturation within the chamber. Summary of the Invention

[0004] To overcome the prior art's lack of methods for simultaneously controlling and maintaining the temperature, hydrogen peroxide concentration, and relative saturation within a confined space for an extended period, the present invention provides a method for maintaining temperature, hydrogen peroxide concentration, and saturation. This method can regulate and maintain the temperature, hydrogen peroxide concentration, and relative saturation within a confined space for an extended period, with minimal fluctuations in temperature, VHP concentration, and relative saturation during control. The present invention also provides an apparatus for this method, capable of simultaneously controlling and maintaining temperature, hydrogen peroxide concentration, and relative saturation over a wide parameter range at ambient temperature and pressure.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A method for maintaining temperature, hydrogen peroxide gas concentration and saturation, comprising the following steps:

[0007] S1: Adjust the temperature of the enclosed space to the target temperature and then dehumidify;

[0008] S2: Vaporize a high-concentration hydrogen peroxide solution with a mass fraction of 20-80% and inject it into the confined space until the difference between the target concentration and the actual concentration in the confined space is less than 50 ppm;

[0009] S3: Vaporize and inject a low-concentration hydrogen peroxide solution with a mass fraction of 1 to 10% into the confined space until the difference between the actual relative saturation and the target saturation is less than 2%;

[0010] S4: When the actual concentration in the confined space is lower than the target concentration by more than 20 ppm, a high-concentration hydrogen peroxide solution is vaporized and injected into the confined space until the difference between the target concentration and the actual concentration is less than 20 ppm; when the actual relative saturation in the confined space is lower than the target saturation by more than 2%, a low-concentration hydrogen peroxide solution is vaporized and injected into the confined space until the difference between the target saturation and the actual relative saturation is less than 2%.

[0011] The present invention simultaneously regulates the hydrogen peroxide concentration and relative saturation inside the confined space by vaporizing a high-concentration hydrogen peroxide solution and a low-concentration hydrogen peroxide solution and injecting them alternately into the confined space. The regulation is precise, and the temperature, hydrogen peroxide concentration and relative saturation in the confined space can be maintained at the set values ​​for a long time with little fluctuation during the maintenance period.

[0012] Preferably, in step S1, the temperature of the enclosed space is adjusted to a target temperature and then dehumidified. The target temperature is 20-40°C. After dehumidification, the humidity of the enclosed space is 5 percentage points or more lower than the required saturation.

[0013] Preferably, the humidity of the enclosed space after dehumidification in step S1 is less than the target saturation by 20 percentage points or more.

[0014] Preferably, the vaporization injection rate of the high-concentration hydrogen peroxide solution in step S2 is 0.1-2 g / min, and the vaporization injection rate of the low-concentration hydrogen peroxide solution in step S3 is 0.1-2 g / min.

[0015] Preferably, step S1 further includes performing a pressure drop test on the enclosed space. After the pressure drop test passes, the temperature of the enclosed space is adjusted to the target temperature and then dehumidification is performed. The pressure drop test step includes:

[0016] (1) Inflate the confined space to a pressure higher than 100 Pa;

[0017] (2) After standing for 3 to 5 minutes, record the starting temperature and starting absolute pressure Ps, then conduct the test. The test time T is 60 to 120 seconds. After the test, record the ending temperature and ending absolute pressure Pt.

[0018] (3) Calculate the hourly volume leakage rate Q / V using the following formula:

[0019] Q / V=3600(Ps-Pt) / (Ps×T);

[0020] The pressure drop test passes when the hourly leakage rate Q / V is less than 0.5% and the temperature fluctuation in the chamber during the measurement process is ≤0.5℃.

[0021] The pressure drop test can detect the sealing degree of the confined space, avoid large fluctuations in the subsequent hydrogen peroxide concentration due to leakage, and prevent hydrogen peroxide leakage from causing harm to experimental personnel.

[0022] A device for the above-mentioned method of maintaining temperature, hydrogen peroxide gas concentration, and saturation comprises a housing and a control system; the housing comprises a closable door, the interior of the housing being a sealed space, equipped with a hydrogen peroxide concentration detection module, a temperature and humidity detection module, and a temperature control module, each of which is respectively connected to the control system circuit; the temperature control module comprises a heating device and a cooling device; the housing is connected to a spray vaporization device and a gas replacement system controlled by the control system; the spray vaporization device is connected to two or more liquid storage tanks for storing hydrogen peroxide solution.

[0023] The device of the present invention has two or more liquid storage tanks, enabling alternating injection of hydrogen peroxide solutions of varying concentrations, thereby regulating the hydrogen peroxide concentration and relative saturation within the chamber. Used as a hydrogen peroxide sterilization biological indicator resistance meter, it can perform biological indicator resistance testing under multiple operating conditions at normal temperature and pressure, helping to establish optimal sterilization conditions and reducing excessive use of hydrogen peroxide solution. It can also be used in sterilization and disinfection devices, such as transfer chambers, isolators, and disinfection cabinets, to improve sterilization effectiveness. Furthermore, the device utilizes a spray vaporization method for hydrogen peroxide injection, replacing the heated vaporization injection method used in existing equipment. This allows the chamber environment to quickly meet test parameter requirements while also avoiding the impact of heated vaporization on chamber temperature maintenance. The heating device, cooling device, and temperature and humidity detection module within the temperature control module work together to control the temperature within the enclosed space, achieving heating, cooling, and insulation functions within a wide control range.

[0024] Preferably, a gas uniformity device is further provided in the box.

[0025] Preferably, the gas uniformizing device is a turbulent flow fan.

[0026] The gas uniformity device can make the gas composition in each part of the box the same.

[0027] Preferably, an inflatable sealing strip is provided on the edge of the hatch of the box body facing the interior of the box body, a window is provided on the hatch, a lighting device is provided in the box body, and an insulation layer is provided on the wall surface inside the box body.

[0028] The inflatable sealing strip is used to enhance the sealing of the box. The experimenter can observe the internal situation of the box through the window, and the lighting device is used for lighting.

[0029] Preferably, the door of the box body is further provided with a tempered glass hinge on the side facing the interior of the box body.

[0030] Setting up tempered glass hinges can enhance the thermal insulation of the box while not hindering the experimenters from observing the internal conditions of the box.

[0031] Preferably, the gas replacement system includes an air inlet and an air outlet arranged on the box body, and a pressure detection module arranged in the box body, the air inlet is connected to the gas tank through a valve, and the air outlet is connected to the exhaust catalytic decomposition device through a valve.

[0032] The gas replacement system dehumidifies the chamber and removes hydrogen peroxide after pressure drop testing and biological indicator resistance testing. The exhaust catalytic decomposition device treats undecomposed hydrogen peroxide to prevent laboratory personnel from inhaling it.

[0033] Preferably, the control system includes a display touch screen.

[0034] The touch screen is used to set the parameters of the cabinet and display the real-time parameter changes in the cabinet.

[0035] Therefore, the present invention has the following beneficial effects:

[0036] (1) By alternately injecting two hydrogen peroxide solutions of different concentrations into a confined space, the hydrogen peroxide concentration and relative saturation inside the confined space can be simultaneously controlled and adjusted. The control range is wide, maintaining the concentration at 0 to 1900 ppm and the relative saturation at 10 to 90%, and the deviation between the actual concentration and relative saturation and the set value is small;

[0037] (2) The temperature, hydrogen peroxide concentration and relative saturation in a confined space can be maintained for a long time, and the fluctuations of temperature, hydrogen peroxide concentration and relative saturation during the control process are small;

[0038] (3) It can be used to verify the temperature and saturation in the biological indicator resistance test, which helps to establish the optimal sterilization conditions and reduce the excessive use of hydrogen peroxide solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 It is a structural diagram of the device of the present invention.

[0040] Figure 2 It is a structural diagram of the interior of the box of the device of the present invention.

[0041] Figure 3 This is the maintenance data diagram of Example 2.

[0042] Figure 4 This is the maintenance data diagram of Example 3.

[0043] Figure 5 This is the maintenance data diagram of Example 4.

[0044] Figure 1 and Figure 2 In the figure, 1-box, 11-door, 111-window, 12-lighting device, 2-hydrogen peroxide concentration detection module, 3-temperature and humidity detection module, 4-spray vaporization device, 41-liquid storage tank, 5-gas uniformity device, 61-air inlet, 62-air outlet, 63-pressure detection module, 7-display touch screen. DETAILED DESCRIPTION

[0045] The present invention will be further described below with reference to the accompanying drawings and specific implementation methods.

[0046] Example 1

[0047] A hydrogen peroxide sterilization biological indicator resistance meter, the structure of which is as follows Figure 1 and Figure 2As shown, it includes an outer frame, in which a box body 1 and two liquid storage tanks 41 respectively filled with a high-concentration hydrogen peroxide solution and a low-concentration hydrogen peroxide solution are provided. The box body 1 is connected to the two liquid storage tanks 41 via a spray vaporization device 4 provided on the left side of the box body 1. The front of the box body 1 is provided with tempered glass hinges and a hinged hatch 11 from the inside to the outside. The outer frame is hollowed out relative to the hatch 11. The middle part of the hatch 11 is a glass window 111. The edge of the hatch 11 facing the inside of the box body 1 is provided with an inflatable sealing strip; the interior of the box body 1 is a closed space, and an LED lamp is provided on the top as a lighting device 12. A gas uniformity device 5, a hydrogen peroxide concentration detection module 2 and a temperature and humidity detection module 3 are provided in the middle of the rear side. The gas uniformity device 5 is a turbulent flow fan. A temperature control module is also provided in the box body 1. The temperature control module includes thermal insulation cotton laid on the inner wall of the box body as an insulation layer, a heating device and a refrigeration device; the box body 1 An air inlet 61, an air outlet 62 and a pressure detection module 63 are provided on the right side. The air inlet 61 is connected to a gas tank filled with dry compressed air through a valve, and the air outlet 62 is connected to a catalytic decomposition device of exhaust gas through a valve. The air inlet 61, the air outlet 62, the gas tank, the pressure detection module 63 and the catalytic decomposition device of exhaust gas constitute a gas replacement system; the hydrogen peroxide sterilization biological indicator resistance meter also includes a control system, which is connected to the lighting device 12, the hydrogen peroxide concentration detection module 2, the temperature and humidity detection module 3, the spray vaporization device 4, the temperature control module, the turbulent flow fan and the gas replacement system circuit. The control system includes a display touch screen 7 arranged on the outer frame.

[0048] The steps for using the hydrogen peroxide sterilization biological indicator resistance instrument to perform a biological indicator resistance test are as follows:

[0049] S1: Preparation stage: Place the biological indicator through the biological indicator exposure device or directly in the box, and use the display touch screen to set the required parameters. The setting range of test temperature is 20-40℃, the setting range of test concentration is 0-1900ppm, the setting range of test saturation is 10-90%, and the setting range of dehumidification humidity is 1-85%;

[0050] S2: Pressure drop test: Turn on the equipment and the box opens to automatically inflate, raising the pressure to above 100 Pa. After inflation, the equipment automatically stabilizes for 3 to 5 minutes, then tests for 1 to 2 minutes. Wait for the test to complete automatically, and record the starting and ending temperatures. The tablet computer control software in the control system monitors the test process in real time and automatically calculates the hourly volume leakage rate using the following formula: Q / V = 3600 (Ps - Pt) / (Ps × T)

[0051] Where: Q / V-hour volume leakage rate;

[0052] Ps (Pa) - initial absolute pressure, which is atmospheric pressure + initial relative pressure. Atmospheric pressure is calculated as 101325 Pa;

[0053] Pt (Pa) - final absolute pressure, which is atmospheric pressure + final relative pressure, where atmospheric pressure is calculated as 101325 Pa;

[0054] T(s)-test time;

[0055] When the hourly leakage rate Q / V is less than 0.5% and the temperature fluctuation in the chamber during the measurement process is ≤0.5°C, the pressure drop test passes and enters the next stage. Step S3: Temperature control stage, the control system controls the temperature of the enclosed space and preheating chamber in the chamber. When the temperature in the chamber reaches the set value, it enters the next stage.

[0056] S4: Dehumidification stage, dry compressed air is introduced into the box through the gas replacement system to dehumidify the box. When the humidity reaches the dehumidification humidity set value, it enters the next stage;

[0057] S5: Adjustment stage: The spray vaporization device vaporizes a 20-80% high-concentration hydrogen peroxide solution into the chamber at a rate of 0.1-2g / min to quickly increase the hydrogen peroxide concentration in the chamber. When the concentration tends to maintain the concentration, the injection of the high-concentration hydrogen peroxide solution is stopped. At this time, the hydrogen peroxide concentration will continue to rise and then slowly decrease. When the concentration begins to decrease, the spray vaporization device vaporizes a 1-10% mass fraction low-concentration hydrogen peroxide solution into the chamber at a rate of 0.1-2g / min to adjust the relative saturation inside the chamber. When the difference between the hydrogen peroxide concentration value in the test chamber and the test concentration is within 20ppm, and the difference between the relative saturation value and the test saturation is within 2%, the next stage is entered;

[0058] S6: Testing phase / maintenance phase. During this phase, the relative saturation and hydrogen peroxide concentration are reduced by air intake and exhaust, the concentration is increased by adding a high-concentration hydrogen peroxide solution, and the saturation is increased by adding a low-concentration hydrogen peroxide solution, thereby achieving long-term maintenance of the concentration and saturation. The biological indicator is exposed in the chamber, removed according to a certain exposure time, and sent to the laboratory for cultivation;

[0059] S7: Residue removal stage: After the test, the test space is cleaned of residues through the intake air, and the exhaust gas enters the exhaust catalytic decomposition device for decomposition and then discharged;

[0060] S8: Theoretical calculation: after the biological indicator culture cycle is completed, calculate the D value of the culture results according to Chinese Pharmacopoeia 9208.

[0061] Example 2

[0062] A method for maintaining the temperature, hydrogen peroxide gas concentration, and saturation in the box of Example 1, comprising the following steps:

[0063] S1: Adjust the chamber temperature to 20°C, set the dehumidification humidity, target concentration and target saturation, and then perform dehumidification;

[0064] S2: A high-concentration hydrogen peroxide solution with a mass fraction of 50% is vaporized at a rate of 1 g / min and injected into the chamber until the difference between the target concentration and the actual concentration in the chamber is less than 50 ppm;

[0065] S3: A low-concentration hydrogen peroxide solution with a mass fraction of 7.5% is vaporized at a rate of 1 g / min and injected into the chamber until the difference between the actual relative saturation and the target saturation is less than 2%;

[0066] S4: When the actual concentration in the box is lower than the target concentration by more than 20 ppm, a high-concentration hydrogen peroxide solution is vaporized and injected into the confined space until the actual concentration is lower than the target concentration by less than 20 ppm; when the actual relative saturation in the box is lower than the target saturation by more than 2%, a low-concentration hydrogen peroxide solution is vaporized and injected into the confined space until the actual relative saturation is lower than the target saturation by less than 2%.

[0067] The setting parameters of Example 2 and the test data during the 60 min maintenance are shown in Table 1 and Figure 3 As the actual temperature in the box fluctuates within the range of 20±0.1℃, the difference from the set value is too small and is ignored.

[0068] Table 1. Test data for Example 2.

[0069]

[0070] Example 3

[0071] A method for maintaining the temperature, hydrogen peroxide gas concentration, and saturation in the box of Example 1 differs from Example 2 in that the box temperature is adjusted to 30° C. for testing, the mass fraction of the high-concentration hydrogen peroxide solution is 50%, and the mass fraction of the low-concentration hydrogen peroxide solution is 7.5%.

[0072] The setting parameters of Example 3 and the test data during the 60-min maintenance process are shown in Table 2 and Figure 4 As the actual temperature in the box fluctuates within the range of 30±0.1℃, the difference from the set value is too small and is ignored.

[0073] Table 2. Example 3 test data.

[0074]

[0075] Example 4

[0076] A method for maintaining the temperature, hydrogen peroxide gas concentration and saturation in the box of Example 1 is different from Example 2 in that the box temperature is adjusted to 40°C for testing.

[0077] The setting parameters of Example 4 and the test data during the 60-min maintenance process are shown in Table 3 and Figure 5 As the actual temperature in the box fluctuates within the range of 40±0.1℃, the difference from the set value is too small and is ignored.

[0078] Table 3. Example 4 test data.

[0079]

[0080] The actual concentration and actual saturation in Table 1-3 are the average values ​​during the maintenance process. The fluctuations of the actual concentration and actual saturation during the maintenance process are as follows: Figure 3-5 The above data show that the present invention can regulate the hydrogen peroxide concentration and saturation in the box to close to the target value at a temperature of 20-40°C, and can maintain the target value for a long time with little fluctuation during the maintenance process.

[0081] Comparative Example 1

[0082] A method for maintaining the concentration and saturation of hydrogen peroxide gas in the box of Example 1, comprising the following steps:

[0083] S1: Adjust the chamber temperature to 25°C, set the dehumidification humidity to 30%, the target concentration to 500ppm, and the target saturation to 50%, and then perform dehumidification;

[0084] S2: A high-concentration hydrogen peroxide solution with a mass fraction of 50% is vaporized at a rate of 1 g / min and then injected into the box until the difference between the target concentration and the actual concentration in the box is less than 20 ppm;

[0085] S3: A high-concentration hydrogen peroxide solution with a mass fraction of 50% is vaporized at a rate of 1 g / min and then injected into the box until the difference between the target saturation and the actual saturation in the box is less than 2%.

[0086] In Comparative Example 1, the actual concentration in the box fluctuated within the range of 696-748 ppm, while the actual relative saturation fluctuated within the range of 46-54%, indicating that using only a high-concentration hydrogen peroxide solution could not maintain both the concentration and the relative saturation.

[0087] Comparative Example 2

[0088] A method for maintaining the concentration and saturation of hydrogen peroxide gas in the box of Example 1, comprising the following steps:

[0089] S1: Adjust the chamber temperature to 25°C, set the dehumidification humidity to 30%, the target concentration to 500ppm, and the target saturation to 50%, and then perform dehumidification;

[0090] S2: A low-concentration hydrogen peroxide solution with a mass fraction of 7.5% is vaporized at a rate of 1 g / min and injected into the chamber until the difference between the target concentration and the actual concentration in the chamber is less than 20 ppm;

[0091] S3: A high-concentration hydrogen peroxide solution with a mass fraction of 7.5% is vaporized at a rate of 1 g / min and then injected into the box until the difference between the target saturation and the actual saturation in the box is less than 2%.

[0092] In Comparative Example 2, the actual concentration in the box fluctuated within the range of 66 to 70 ppm, while the actual saturation fluctuated within the range of 50 to 52%. Since only adding a low-concentration hydrogen peroxide solution can only obtain a low-concentration, highly saturated VHP detection environment, the resistometer remained in the adjustment stage during operation and controlled the actual saturation to be near the set saturation.

[0093] The test results of Comparative Examples 2 and 3 show that using only one concentration of hydrogen peroxide solution cannot maintain both concentration and relative saturation.

Claims

1. A method for maintaining temperature, hydrogen peroxide gas concentration and saturation, characterized in that: The steps include: S1: Adjust the temperature of the enclosed space to the target temperature and then dehumidify; S2: Vaporize a high-concentration hydrogen peroxide solution with a mass fraction of 20-80% and inject it into the confined space until the difference between the target concentration and the actual concentration in the confined space is less than 50 ppm; S3: A low-concentration hydrogen peroxide solution with a mass fraction of 1-10% is vaporized and injected into a confined space. The difference between the actual relative saturation and the target saturation is less than 2%. S4: When the actual concentration in the confined space is lower than the target concentration by more than 20 ppm, a high-concentration hydrogen peroxide solution is vaporized and injected into the confined space until the difference between the target concentration and the actual concentration is less than 20 ppm; When the actual relative saturation in the confined space is lower than the target saturation by more than 2%, a low-concentration hydrogen peroxide solution is vaporized and injected into the confined space until the difference between the target saturation and the actual relative saturation is less than 2%.

2. The method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 1, wherein: In step S1, the temperature of the enclosed space is adjusted to the target temperature and then dehumidified. The target temperature is 20~40℃. After dehumidification, the humidity of the enclosed space is less than the required saturation by 5 percentage points or more.

3. The method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 2, wherein: After dehumidification in step S1, the humidity of the enclosed space is less than the target saturation by 20 percentage points or more.

4. The method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 1, wherein: The vaporization injection rate of the high-concentration hydrogen peroxide solution in step S2 is 1-2 g / min, and the vaporization injection rate of the low-concentration hydrogen peroxide solution in step S3 is 1-2 g / min.

5. A method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 1, 2 or 3, characterized in that: Step S1 also includes performing a pressure drop test on the enclosed space. After the pressure drop test passes, the temperature of the enclosed space is adjusted to the target temperature and then dehumidification is performed. The pressure drop test step includes: (1) Inflate the confined space to a pressure higher than 100 Pa; (2) After standing for 3 to 5 minutes, record the starting temperature and starting absolute pressure Ps, then conduct the test. The test time T is 60 to 120 seconds. After the test, record the ending temperature and ending absolute pressure Pt. (3) Calculate the hourly volume leakage rate Q / V using the following formula: Q / V=3600(Ps-Pt) / (Ps×T); The pressure drop test passes when the hourly leakage rate Q / V is less than 0.5% and the temperature fluctuation in the chamber during the measurement process is ≤0.5℃.

6. A method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 1, 2, 3 or 4, characterized in that: The invention comprises a box (1) and a control system; the box comprises a closable hatch (11); the interior of the box is a closed space, and is provided with a hydrogen peroxide concentration detection module (2), a temperature and humidity detection module (3), and a temperature control module respectively connected to the control system circuit; the temperature control module comprises a heating device and a cooling device; the box is connected to a spray vaporization device (4) controlled by the control system and a gas replacement system; the spray vaporization device is connected to two or more liquid storage tanks (41) for storing hydrogen peroxide solution.

7. The method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 6, wherein: A gas uniformity device (5) is also provided in the box.

8. The method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 6, wherein: An inflatable sealing strip is provided on the edge of the hatch of the box body facing the interior of the box body, a viewing window (111) is provided on the hatch, a lighting device (12) is provided in the box body, and a heat-insulating layer is provided on the wall surface inside the box body.

9. The method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 6, wherein: The gas replacement system comprises an air inlet (61) and an air outlet (62) arranged on a box body, and a pressure detection module (63) arranged in the box body, wherein the air inlet is connected to the gas tank via a valve, and the air outlet is connected to the exhaust gas catalytic decomposition device via a valve.

10. The method for maintaining temperature, hydrogen peroxide gas concentration and saturation according to claim 6, wherein: The control system comprises a display touch screen (7).

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