A Chinese medicine composition, preparation and preparation method for treating lumbar disc herniation

Abstract

The present invention relates to the technical field of traditional Chinese medicine (IPC classification number is A61P19 / 02), and in particular to a traditional Chinese medicine composition, preparation and preparation method for treating lumbar disc herniation. The composition is formulated according to monarch, minister, assistant and guiding drugs, and the ingredients and weight proportions thereof are as follows: (1) monarch drugs are 5-15 g of black plum and 10-20 g of mistletoe; (2) assistant drugs are 10-20 g of cyathulae, 10-20 g of radix strychnos, 10-20 g of eucommia bark and 10-20 g of rhizoma drynariae; (3) adjuvant drugs are 10-20 g of white peony root, 3-10 g of safflower, 10-20 g of atractylodes macrocephala and 10-20 g of millettia reticulata; (4) guiding drug is 3-10 g of angelica dahurica.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine (IPC classification number is A61P19 / 02), and in particular to a traditional Chinese medicine composition, a preparation and a preparation method for treating lumbar disc herniation. Background Art

[0002] Neck, shoulder, waist and leg pain refers to dysfunctional and injury pain in the soft tissues such as joints, muscles, ligaments, etc. in the neck, shoulders, waist and legs, which is particularly common in middle-aged and elderly people. Although neck, shoulder, waist and leg pain is more common in people who do excessive physical labor, due to changes in modern lifestyles and the accelerated pace of society, the incidence population is becoming more and more popular and younger. For example, driving for a long time or using a computer, because of maintaining a posture for a long time, it is easy to cause chronic strain of muscles and ligaments, neck soreness, shoulder pain, back discomfort, etc. Or staying in an air-conditioned room for a long time, the shoulders or knees are easily invaded by cold evil, which will develop into cervical spondylosis, periarthritis of the shoulder, lumbar muscle strain, lumbar disc herniation, knee arthritis, etc. over time, and with the increase of age, the degenerative changes of bones and joints will aggravate the pain.

[0003] Chinese patent CN 108721466 A discloses a drug for treating lumbar, shoulder and cervical discomfort, which is prepared with 32 Chinese medicinal herbs such as golden-edged earthworm, notopterygium wilfordii, and Chuanxiong, and has the efficacy of radically curing cervical spondylosis, scapulohumeral periarthritis, lumbar spondylosis, and lumbar disc herniation. However, it has many medicinal ingredients, has large toxic and side effects, and is not suitable for long-term use. Summary of the invention

[0004] The first aspect of the present invention provides a traditional Chinese medicine composition for treating lumbar disc herniation, which is formulated according to monarch, minister, assistant and guiding ingredients, and its composition is as follows:

[0005] (1) The main medicines are: Wumei and Tanzhisheng;

[0006] (2) The assistant drugs are: Achyranthes bidentata, Rhizoma Cynanchum, Eucommia ulmoides, and Rhizoma Drynariae;

[0007] (3) Adjuvant drugs: white peony root, safflower, atractylodes macrocephala, Millettia reticulata;

[0008] (4) The adjuvant drug is Angelica dahurica.

[0009] As a preferred embodiment, the formula is prepared according to the monarch, minister, assistant and envoy, and the ingredients and weight portions are as follows:

[0010] (1) The main drugs are: Prunus mume 5-15g, Morus alba 10-20g;

[0011] (2) The auxiliary drugs are: Achyranthes bidentata 10-20g, Rhizoma Cynanchum 10-20g, Eucommia ulmoides 10-20g, Rhizoma Drynariae 10-20g;

[0012] (3) Adjuvant drugs: white peony root 10-20g, safflower 3-10g, atractylodes macrocephala 10-20g, Millettia reticulata 10-20g;

[0013] (4) The adjuvant drug is: 3-10g of Angelica dahurica.

[0014] Junyao

[0015] Wumei: It is mild and sour, and its effect is to soften the liver and nourish the tendons. It can treat limb pain, hemiplegia, and loose tendons or pain caused by dampness infiltrating the meridians, and it has a good effect of clearing the joints, nourishing the liver and softening the tendons. "Shennong's Herbal Classic" says that Wumei "can relieve qi, eliminate heat and fullness, calm the mind, stop limb pain, hemiplegia, dead muscles, remove dark hemorrhoids, and erode bad flesh", indicating that Wumei is effective in stopping limb pain.

[0016] Mulberry parasite: It is mild and slightly bitter, and it enters the liver and kidney meridians. It has the effects of nourishing the liver and kidney, strengthening the tendons and bones, removing rheumatism, unblocking the meridians, and replenishing qi and blood. It can be used to treat sore waist and knees, weak tendons and bones, hemiplegia, beriberi, and wind-cold-dampness arthralgia. It is especially suitable for people with long-term arthralgia, damage to the liver and kidney, sore waist and knees, and weak tendons and bones. It is also effective for sore waist and knees and weak tendons and bones caused by liver and kidney yin deficiency.

[0017] The above two herbs work together to dispel wind and dampness, nourish blood and nourish blood, and activate meridians and relieve numbness, and they are both the main medicines.

[0018] Minister medicine

[0019] Achyranthes bidentata: Achyranthes bidentata is bitter and can relieve descent, sour and enter the liver, sweet and can replenish and penetrate, good at descending, and enter the liver and kidney meridians. Raw use is bitter, flat and slightly cool, can promote descent and relieve descent, can remove blood stasis and promote menstruation, and treat blood stasis during menstruation and childbirth and arthralgia and cramps. Processed use is sweet, flat and slightly warm, good at replenishing deficiency, good at replenishing liver and kidney, and strengthening tendons and bones. It is an important medicine for treating soreness of waist and knees, and weakness of tendons and bones. In addition, this product mainly contains sterone components, triquito saponins components, flavonoid components, polysaccharides and amino acids. It has the effects of promoting blood circulation and dredging menstruation, guiding blood downward, replenishing liver and kidney, and strengthening tendons and bones.

[0020] Niu Da Li: sweet and flat in nature, it enters the lung and kidney meridians, and has the effects of strengthening yang, nourishing the kidney and replenishing deficiency, strengthening tendons and activating collaterals. It is mainly used to treat kidney deficiency, qi deficiency, back pain and leg pain, lumbar muscle strain, rheumatism, etc.

[0021] Eucommia: Eucommia is sweet and warm in nature, and enters the liver and kidney meridians. It has strong medicinal properties, and is good at warming and nourishing the liver and kidneys, strengthening tendons and bones, and calming the fetus, and lowering blood pressure. It is not only an important medicine for treating kidney deficiency, back pain, or weakness of tendons and bones, but also a good medicine for treating liver and kidney deficiency and miscarriage. This product contains eucommia gum, eucommia glycosides, pinoresinol diglucoside, aucubin, tannins, flavonoids, etc., which have the functions of nourishing the liver and kidneys and strengthening tendons and bones.

[0022] Drynaria: Drynaria is bitter and warm in nature, belonging to the liver and kidney meridians. As a blood-activating and stasis-removing medicine, it has the effects of healing wounds and relieving pain, tonifying the kidney and strengthening bones. It can be used for falls, sprains, tendon fractures, kidney deficiency and low back pain, tendon and bone weakness, etc.

[0023] The above four herbs all have the function of nourishing the liver and kidneys and strengthening the tendons and bones, and are collectively referred to as assistant herbs.

[0024] Adjuvant

[0025] White peony root: pungent and bitter, with the effects of warming yang, removing dampness, and replenishing body deficiency. It can be used to treat rheumatism, cold pain, rheumatoid arthritis, lumbar muscle strain, physical weakness, limb convulsions, slow convulsions and other symptoms.

[0026] Safflower: Safflower is pungent, dispersing, warming and unblocking. It enters the heart and liver meridians. It is good at promoting blood circulation, removing blood stasis, relieving swelling and relieving pain. It has strong medicinal properties and can be used to treat all symptoms of blood stasis, especially those with cold. It has the effects of promoting blood circulation, unblocking blood stasis and relieving pain. It can be used to treat joint pain caused by blood stasis and blocked tendons.

[0027] Atractylodes: Atractylodes is sweet, nourishing, bitter, warm and dry. It enters the spleen and stomach meridians. It mainly warms and nourishes the body, and can also remove dampness. It is good at drying dampness and promoting diuresis, and has a certain effect on muscle soreness and joint pain caused by dampness infiltrating the meridians.

[0028] Caulis Spatholobi: Caulis Spatholobi is bitter, warming and unblocking, slightly sweet and nourishing, and enters the liver and kidney meridians. It can promote blood circulation and relieve pain, and it can also replenish blood and relax muscles and relieve pain. It can be used to treat blood stasis, blood deficiency and cold symptoms. It is most suitable for people with numbness and pain caused by blood deficiency. This product contains isoflavones, flavonoids, flavan (alcohol) compounds, terpenoids, and steroid compounds such as β-sitosterol and Caulis Spatholobi alcohol. It has the effects of promoting blood circulation and replenishing blood, regulating menstruation and relieving pain, and relaxing muscles and activating collaterals. It can be used to treat joint pain, limb soreness, lumbar muscle strain, etc.

[0029] The above four herbs can either replenish blood and promote blood circulation, or invigorate qi and strengthen the spleen. They are all adjuvants that can make qi and blood vigorous and help eliminate rheumatism.

[0030] Drug

[0031] Angelica dahurica: Angelica dahurica is pungent, warming and dry, aromatic and can open the orifices. It mainly enters the Yangming meridian and also the Taiyin meridian. It is good at dispersing wind and cold, removing dampness, opening the nasal orifices and joints, and is also good at relieving pain, relieving leukorrhea, and stopping leukorrhea. It can also dissipate lumps and promote the discharge of pus. It has a strong medicinal effect and is suitable for all symptoms caused by wind and cold, wind and cold with dampness, and cold and dampness. It is effective for joint pain caused by cold and dampness.

[0032] The combination of the main, secondary, auxiliary and guiding drugs is a drug that takes both the symptoms and the root cause into consideration, strengthens the body and eliminates the evil. It has a good therapeutic effect on the arthralgia caused by the three qi of wind, cold and dampness in the tendons and bones.

[0033] The second aspect of the present invention provides a traditional Chinese medicine preparation, which is composed of the traditional Chinese medicine composition and pharmaceutically acceptable excipients.

[0034] As a preferred embodiment, the Chinese medicine preparation is one or more of a pill, a tablet, a granule, a capsule, a powder, a pill, and an oral liquid.

[0035] Preferably, the Chinese medicine preparation is a granule.

[0036] The third aspect of the present invention provides a method for preparing a Chinese medicine composition for treating lumbar disc herniation, comprising the following steps:

[0037] S1. The black plum, mistletoe, Achyranthes bidentata, Niu Dali, Eucommia ulmoides, Drynaria, white peony root, safflower, Atractylodes macrocephala, Millettia reticulata, Angelica dahurica were crushed into powder and sieved to obtain a powder for later use;

[0038] S2. Dissolve the two main drug powders in ethanol, microwave for 2-5 times, 10-15 min each time, combine the extracts, and concentrate under reduced pressure to obtain a mixture A;

[0039] S3. The powder of the ministerial drug was dissolved in ethanol, microwaved 2-5 times, each time for 10-15 min, the extracts were combined, and concentrated under reduced pressure to an extract to obtain a mixture B;

[0040] S4. After mixing mixture A, mixture B, adjuvant and drug, add ethanol and stir evenly, raise the temperature to 70-75°C and heat and stir at this temperature for 1-1.2 hours, then ultrasonically treat for 10-15 minutes, centrifuge, take the filtrate, and stir at 70-75°C until dry to obtain the drug.

[0041] As a preferred embodiment, the screening is through a 150-250 mesh sieve.

[0042] In a specific embodiment, the mesh size may be 150 mesh, 160 mesh, 170 mesh, 180 mesh, 190 mesh, 200 mesh, 210 mesh, 220 mesh, 230 mesh, 240 mesh, 250 mesh, preferably 200 mesh.

[0043] As a preferred embodiment, the mass ratio of the main drug powder to ethanol in S2 is 1:(8-15).

[0044] In a specific embodiment, the mass ratio can be 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, preferably 1:10.

[0045] As a preferred embodiment, the volume ratio of the auxiliary drug powder to ethanol in S3 is 1:(8-15).

[0046] In a specific embodiment, the mass ratio can be 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, preferably 1:10.

[0047] As a preferred embodiment, the mass ratio of the total mass of mixture A, mixture B, adjuvant, and drug to ethanol in S4 is 1:(8-15).

[0048] In a specific embodiment, the mass ratio can be 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, preferably 1:10.

[0049] Compared with the prior art, the present invention has the following beneficial effects:

[0050] Efficacy: Relieves pain, benefits the liver and kidneys, and replenishes qi and blood.

[0051] Indications: Liver and kidney deficiency, Qi and blood deficiency. Waist and knee pain, lumbar disc herniation and weakness, limb discomfort, or numbness, fear of cold and preference for warmth, palpitations and shortness of breath, pale tongue with white coating, and weak pulse.

[0052] 1. The composition preparation provided by the present invention is safe and effective, has a simple manufacturing process, has little toxic and side effects, is easy to manufacture, and has low cost. The composition provides benign stimulation to the lesion, has the effects of dispelling wind and activating blood circulation, strengthening tendons and waist, unblocking meridians, eliminating qi and blood stagnation, promoting blood circulation, nourishing the kidney and replenishing essence, activating blood circulation and removing blood stasis, unblocking meridians and relieving pain, achieving the effects of strengthening the body and eliminating evil, and can be effectively used for the treatment of lumbar disc herniation.

[0053] 2. Clinical trials have shown that the efficacy of the present invention in treating patients with lumbar disc herniation is greater than 90%, indicating that the present invention can effectively treat lumbar disc herniation.

[0054] 3. The Chinese medicine composition preparation provided by the present invention has a scientific and reasonable formula, simple process, good taste and low cost. DETAILED DESCRIPTION

[0055] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0056] Example 1

[0057] A Chinese medicine composition for treating lumbar disc herniation is formulated according to the main, secondary, auxiliary and guiding ingredients, and its ingredients and weight portions are as follows:

[0058] (1) The main drugs are: Prunus mume 5g, Morus alba 10g;

[0059] (2) The auxiliary drugs are: Achyranthes bidentata 10g, Rhizoma Cynanchum 10g, Eucommia ulmoides 10g, Rhizoma Drynariae 10g;

[0060] (3) Adjuvant drugs: white peony root 10g, safflower 3g, atractylodes 10g, Millettia reticulata 10g;

[0061] (4) The adjuvant drug is: Angelica dahurica 3g.

[0062] The preparation method of the traditional Chinese medicine composition for treating lumbar disc herniation comprises the following steps:

[0063] S1. The black plum, mistletoe, Achyranthes bidentata, Niu Dali, Eucommia ulmoides, Drynaria, white peony root, safflower, Atractylodes macrocephala, Millettia reticulata, Angelica dahurica were crushed into powder and passed through a 200-mesh sieve to obtain a powder for later use;

[0064] S2. The two main drug powders were dissolved in 10 times the mass of ethanol and microwaved for 3 times, specifically: wavelength 1mm-1m, frequency 400MHzMHz, temperature 45°C, each time for 12min, the extracts were combined, and the extracts were concentrated under reduced pressure to obtain a mixture A;

[0065] S3. The powder of the ministerial drug was dissolved in 10 times the mass of ethanol, and microwaved 3 times, with a wavelength of 1mm-1m, a frequency of 400MHzMHz, a temperature of 45°C, and each time for 12min. The extracts were combined and concentrated under reduced pressure to an extract to obtain a mixture B;

[0066] S4. After mixing mixture A, mixture B, adjuvant and drug, add 10 times the mass of ethanol and stir evenly, raise the temperature to 74°C and heat and stir at this temperature for 1 hour, then ultrasonically treat for 15 minutes, centrifuge, take the filtrate, and stir at 75°C until dry to obtain the drug.

[0067] Example 2

[0068] A Chinese medicine composition for treating lumbar disc herniation is formulated according to the main, secondary, auxiliary and guiding ingredients, and its ingredients and weight portions are as follows:

[0069] (1) The main drugs are: Prunus mume 10g, Morus alba 15g;

[0070] (2) The auxiliary drugs are: Achyranthes bidentata 15g, Rhizoma Cynanchum 15g, Eucommia ulmoides 15g, Rhizoma Drynariae 15g;

[0071] (3) Adjuvant drugs: white peony root 15g, safflower 5g, atractylodes 15g, Millettia reticulata 15g;

[0072] (4) The adjuvant drug is Angelica dahurica 6g.

[0073] The preparation method of the traditional Chinese medicine composition for treating lumbar disc herniation comprises the following steps:

[0074] S1. The black plum, mistletoe, Achyranthes bidentata, Niu Dali, Eucommia ulmoides, Drynaria, white peony root, safflower, Atractylodes macrocephala, Millettia reticulata, Angelica dahurica were crushed into powder and passed through a 200-mesh sieve to obtain a powder for later use;

[0075] S2. The two main drug powders were dissolved in 13 times the mass of ethanol, microwaved 4 times, with a wavelength of 1mm-1m, a frequency of 600MHz, a temperature of 60°C, and each time for 10min. The extracts were combined and concentrated under reduced pressure to an extract to obtain a mixture A.

[0076] S3. The powder of the ministerial drug was dissolved in 13 times the mass of ethanol, and microwaved 4 times, with a wavelength of 1mm-1m, a frequency of 600MHz, a temperature of 60°C, and each time for 10min. The extracts were combined and concentrated under reduced pressure to an extract to obtain a mixture B;

[0077] S4. After mixing mixture A, mixture B, adjuvant and drug, add 15 times the mass of ethanol and stir evenly, raise the temperature to 70°C and heat and stir at this temperature for 1 hour, then ultrasonically treat for 15 minutes, centrifuge, take the filtrate, and stir at 70°C until dry to obtain the drug.

[0078] Example 3

[0079] A Chinese medicine composition for treating lumbar disc herniation is formulated according to the main, secondary, auxiliary and guiding ingredients, and its ingredients and weight portions are as follows:

[0080] (1) The main medicine is: Wumei 15g, Tanjisheng 20g

[0081] (2) The auxiliary drugs are: Achyranthes bidentata 20g, Radix Eucommiae 20g, Rhizoma Drynariae 20g

[0082] (3) Adjuvant drugs: White Peony 20g Safflower 10g Atractylodes 20g Millettia reticulata 20g

[0083] (4) The adjuvant drug is: Angelica dahurica 9g

[0084] The preparation method of the traditional Chinese medicine composition for treating lumbar disc herniation comprises the following steps:

[0085] S1. The black plum, mistletoe, Achyranthes bidentata, Niu Dali, Eucommia ulmoides, Drynaria, white peony root, safflower, Atractylodes macrocephala, Millettia reticulata, Angelica dahurica were crushed into powder and passed through a 200-mesh sieve to obtain a powder for later use;

[0086] S2. Dissolve the two main drug powders in 12 times the mass of ethanol, microwave twice, select wavelength 1mm-1m, frequency 500MHz, temperature 55℃, each time 15min, combine the extracts, and concentrate under reduced pressure to obtain a mixture A;

[0087] S3. The powder of the ministerial drug was dissolved in 12 times the mass of ethanol, and microwaved twice, with a wavelength of 1mm-1m, a frequency of 500MHz, a temperature of 55°C, and each time for 15min. The extracts were combined and concentrated under reduced pressure to an extract to obtain a mixture B;

[0088] S4. After mixing mixture A, mixture B, adjuvant and drug, add 10 times the mass of ethanol and stir evenly, raise the temperature to 75°C and heat and stir at this temperature for 1.2 hours, then ultrasonically treat for 15 minutes, centrifuge, take the filtrate, and stir at 75°C until dry to obtain the drug.

[0089] Clinical trials:

[0090] (1) Clinical subjects

[0091] A total of 171 patients with lumbar disc herniation of wind-cold-dampness syndrome were selected and divided into three groups: the first group consisted of 58 patients, the second group consisted of 63 patients, and the third group consisted of 50 patients.

[0092] (2) Treatment options

[0093] The first group took the Chinese medicine composition prepared in Example 1: granules, one dose per day, twice a day, each time with 200 mL of boiled water, after meals, and avoid taking raw and cold food.

[0094] The second group took the Chinese medicine composition prepared in Example 2: granules, one dose per day, twice a day, each time with 200 mL of boiled water, taken after meals, avoiding taking raw and cold food.

[0095] The third group took the Chinese medicine composition prepared in Example 3: granules, one dose per day, twice a day, each time with 200 mL of boiled water, after meals, avoid taking raw and cold food.

[0096] (3) Treatment effect evaluation criteria

[0097] The treatment effect was evaluated according to the Chinese medicine industry standard of the People's Republic of China, "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes" (ZY / T001.1-94), and the osteoarthritis-related efficacy judgment standards of the 1994 "Guiding Principles for Clinical Research of New Chinese Medicines":

[0098] Significant effect: pain and swelling symptoms disappear, joint movement is not restricted

[0099] Effective: Pain and swelling symptoms are basically eliminated, and joint movement is slightly restricted

[0100] Ineffective: No significant improvement in pain, swelling, and joint activity

[0101] (4) Treatment outcome statistics

[0102] Group 1: 46 patients with marked effect, accounting for 79.3%; 51 patients with effective effect, accounting for 87.9%; 7 patients with ineffective effect, accounting for 12.1%; among them, the number of effective patients includes the number of patients with marked effect.

[0103] Group 2: 51 patients with marked effect, accounting for 82.0%; 57 patients with effective effect, accounting for 90.5%; 6 patients with ineffective effect, accounting for 9.5%; among them, the number of effective patients includes the number of patients with marked effect.

[0104] Group 3: 41 patients with marked effect, accounting for 82%; 45 patients with effective effect, accounting for 90%; 5 patients with ineffective effect, accounting for 10%; among them, the number of effective patients includes the number of patients with marked effect.

[0105] Typical cases of treating lumbar disc herniation by taking the pharmaceutical composition of the present invention:

[0106] Typical Case 1

[0107] Lu, male, 55 years old, came to seek treatment on October 15, 2019. He is a cleaner who has suffered from low back pain for more than 10 years. In the past, lumbar CT scan showed mild protrusion of L4 / 5 lumbar intervertebral disc. He accidentally sprained his waist while cleaning and carrying heavy objects. At that time, his waist and right lower limbs were painful. The whole waist muscle group was stiff like a board, the tongue coating was thick and greasy, and the pulse was tight.

[0108] Diagnosis: Lumbar sprain, lumbar disc herniation.

[0109] Prescription: Wumei 10g, Tanjisheng 15g, Achyranthes bidentata 15g, Eucommia ulmoides 15g, Drynaria fortunei 15g, White peony root 15g, Safflower 5g, Atractylodes macrocephala 15g, Millettia reticulata 15g, Angelica dahurica 6g. A total of 3 doses, one dose a day, twice a day, each time with 200mL of boiled water, take after meals, avoid taking raw and cold food.

[0110] On October 18, 2019, Lu came for a follow-up visit on foot and said that the pain had been reduced by more than half. He was prescribed three doses of the original prescription, and the pain in his right leg disappeared, but there was a slight swelling and pain in his waist. After symptomatic consolidation treatment, he recovered a week later.

[0111] Typical Case 2

[0112] Mr. Huang, male, 45 years old, came for treatment on January 10, 2021.

[0113] Chief complaint: Low back pain for more than a year, aggravated for half a month.

[0114] Current medical history: The patient has been driving for a long time. He complained of lower back pain and discomfort without obvious cause 1 year ago, which was slightly relieved after rest. In the past half month, the pain and discomfort have become significantly worse due to long-term driving, and he has difficulty sleeping at night. He has received acupuncture, massage, and cupping locally, but the symptoms have not improved.

[0115] Good. Physical examination: Wide range of back tenderness, lumbar muscle tension and spasm. Obvious tenderness in bilateral lumbar transverse processes, lumbar spinous processes and posterior margin of iliac crest, no obvious abnormality in lumbar range of motion.

[0116] Auxiliary examination: Lumbar anteroposterior X-ray showed "the physiological curvature of the lumbar spine has become straightened, and lumbar degenerative lesions have occurred."

[0117] Diagnosis: Lumbar muscle strain.

[0118] Prescription: Wumei 10g, Tanjisheng 15g, Achyranthes bidentata 15g, Eucommia ulmoides 15g, Drynaria fortunei 15g, White peony root 15g, Safflower 5g, Atractylodes macrocephala 15g, Millettia reticulata 15g, Angelica dahurica 6g. A total of 3 doses, one dose a day, twice a day, each time with 200mL of boiled water, take after meals, avoid taking raw and cold food.

[0119] After taking the medicine for 3 days, the soreness and discomfort in the waist was significantly relieved. After symptomatic consolidation treatment, the patient took the original prescription for another 7 doses, and the waist pain disappeared and the patient was able to move normally.

[0120] Typical Case 3

[0121] Mr. Chen, male, 59 years old, came for treatment on April 12, 2018.

[0122] Chief complaint: Low back and leg pain for 3 months.

[0123] Main symptoms: The patient had leg pain, numbness and swelling in the buttocks. Examination showed tenderness in L4-5 and L5-S1, and leg raising test (+). CT examination showed L4 / 5, 5 / S1 lumbar disc herniation and L5 / S1 disc stenosis.

[0124] The patient is of medium build, in average spirits, with a pale tongue, thin fur and a weak pulse.

[0125] Syndrome type: liver and kidney deficiency.

[0126] Treatment method: Nourish the liver and kidneys.

[0127] Prescription: Wumei 10g, Tanjisheng 15g, Achyranthes bidentata 15g, Eucommia ulmoides 15g, Drynaria fortunei 15g, White peony root 15g, Safflower 5g, Atractylodes macrocephala 15g, Millettia reticulata 15g, Angelica dahurica 6g. Take 7 doses of decoction, one dose a day, twice a day, each time with 200mL of boiled water, take after meals, avoid taking raw and cold food.

[0128] The patient felt good after taking the above medicine, without any discomfort. On April 19, 2018, the second visit continued with 7 doses of the above medicine. On April 26, 2018, the third visit continued with 7 doses of the above medicine for a total of 3 courses. After 21 doses of treatment, the patient's numbness and swelling in the buttocks disappeared, and the pain and soreness in the calf disappeared, and he could walk and sit normally.

[0129] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating lumbar disc herniation, characterized in that: The formula is formulated according to the monarch, minister, assistant and envoy, and its ingredients and weight proportions are as follows: (1) The main drugs are: Prunus mume 5-15g, Morus alba 10-20g; (2) The auxiliary drugs are: Achyranthes bidentata 10-20g, Rhizoma Cynanchum 10-20g, Eucommia ulmoides 10-20g, Rhizoma Drynariae 10-20g; (3) Adjuvant drugs: white peony root 10-20g, safflower 3-10g, atractylodes macrocephala 10-20g, Millettia reticulata 10-20g; (4) The adjuvant drug is: Angelica dahurica 3-10g; The preparation method of the Chinese medicine composition comprises the following steps: S1. The black plum, mistletoe, Achyranthes bidentata, Niu Dali, Eucommia ulmoides, Drynaria, white peony root, safflower, Atractylodes macrocephala, Millettia reticulata, Angelica dahurica were crushed into powder and sieved to obtain a powder for later use; S2. Dissolve the two main drug powders in ethanol, microwave for 2-5 times, each time for 10-15 min, combine the extracts, and concentrate under reduced pressure to obtain a mixture A; S3. The powder of the ministerial drug was dissolved in ethanol, microwaved 2-5 times, each time for 10-15 min, the extracts were combined, and concentrated under reduced pressure to an extract to obtain a mixture B; S4. Mix mixture A, mixture B, adjuvant and drug, add ethanol and stir evenly, heat to 70-75°C and heat and stir at this temperature for 1-1.2h, then ultrasonically treat for 10-15min, centrifuge, take the filtrate, and stir at 70-75°C until dry to obtain the drug; The sieving is through a 150-250 mesh sieve; The mass ratio of the main drug powder to ethanol in S2 is 1:(8-15); The volume ratio of the auxiliary drug powder to ethanol in S3 is 1:(8-15); The mass ratio of the total mass of the mixture A, the mixture B, the adjuvant, the auxiliary drug and the ethanol in the S4 is 1:(8-15).

2. A Chinese medicine preparation, characterized in that: The composition is composed of the Chinese medicine composition according to claim 1 and pharmaceutically acceptable excipients.

3. A Chinese medicine preparation according to claim 2, characterized in that: The Chinese medicine preparation is one or more of a pill, tablet, granule, capsule, powder, pill, and oral liquid.

4. A Chinese medicine preparation according to claim 2, characterized in that: The traditional Chinese medicine preparation is a granule.