A radio-pharmaceutical dispensing system and method

By pumping clean air into the drug storage tank to generate a vortex flow and combining it with real-time monitoring technology, the problem of uneven mixing of radioactive drugs was solved, achieving efficient drug uniformity and precise drug delivery.

CN117342088BActive Publication Date: 2026-02-13CHONGQING JIANAN INSTR
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Patent Information

Application Number
CN202311556474.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-11-21
Publication Date
2026-02-13
Estimated Expiration
2043-11-21

AI Technical Summary

Technical Problem

In existing technologies, the natural diffusion and mixing of radioactive agents with distilled water is uneven, leading to large errors in the dosage taken by patients and posing a radiation safety hazard.

Method used

Clean air is pumped into the drug storage tank through the air inlet to generate a vortex flow. The uniformity of the drug is monitored in real time by combining an ultrasonic level gauge, a plastic scintillation detector, and a Geiger counter. The passive efficiency is calibrated using the Monte Carlo method to control the drug dosage via a solenoid valve.

Benefits of technology

It enables uniform mixing and precise administration of radiopharmaceuticals, reduces radiation safety risks, and improves the accuracy of medication administration.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application discloses a kind of radioactive medicament subpackaging system and method, the system includes medicament storage tank and medicine cup, medicament storage tank is equipped with dosing port, water inlet, air inlet and dosing port, air inlet is connected air pump by air inlet pipe;Medicament storage tank top is equipped with ultrasonic liquid level meter and plastic flash detector, and the measuring head of ultrasonic liquid level meter and the detection head of plastic flash detector are inserted into medicament storage tank;It also includes Geiger counter, main control module, display module and power module, and the medical radioisotope database is stored in main control module;Ultrasonic liquid level meter, plastic flash detector and Geiger counter are connected with main control module, to transmit measured data to main control module, main control template and air pump are connected;Dosing port is equipped with electromagnetic valve, main control template and electromagnetic valve are connected, to control dosing amount by ultrasonic liquid level meter feedback signal real-time control electromagnetic valve.The application can effectively guarantee the uniformity of radioactive medicament dilution, improve the precision of patient dosage.
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Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of nuclear medicine, and particularly relates to a radio-pharmaceutical dispensing system and method. BACKGROUND

[0002] Radio-pharmaceuticals refer to radioactive nuclide preparations or labeled compounds thereof for clinical diagnosis or treatment, and contain radioactive nuclides that can emit different kinds of rays.

[0003] When a radio-pharmaceutical production enterprise sends oral radio-pharmaceuticals to a hospital nuclear medicine department, the oral radio-pharmaceuticals are usually small in volume and high in concentration from the perspective of transportation safety; after the high-concentration oral radio-pharmaceuticals are sent to the hospital, the hospital generally dilutes the high-concentration oral radio-pharmaceuticals for the convenience of dispensing, and then dispenses them to patients for taking.

[0004] However, during the dispensing process, the radio-pharmaceuticals and distilled water are difficult to be mixed uniformly in a short time by natural diffusion; in addition, the radio-pharmaceuticals are pumped by a sampling pump to measure the volume of the radio-pharmaceuticals for dispensing to patients, and the error is large due to the lack of measurement of radioactivity, which leads to a large deviation between the amount of radio-pharmaceuticals taken by the patients and the prescription dose given by the doctor, and causes a certain safety hazard to the radiation safety of the patients. SUMMARY

[0005] In view of the above problems in the prior art, the purpose of the present application is to provide a radio-pharmaceutical dispensing system and method, which can effectively ensure the uniformity of the diluted radio-pharmaceuticals and improve the accuracy of the amount of radio-pharmaceuticals taken by patients,

[0006] The technical scheme of the present application is as follows:

[0007] A radio-pharmaceutical dispensing system comprises a radio-pharmaceutical storage tank and a medicine cup, the radio-pharmaceutical storage tank is provided with a medicine adding port, a water adding port, an air inlet and a dispensing port, the medicine adding port is used for adding radio-pharmaceuticals, and the water adding port is used for adding distilled water; the air inlet is connected to an air pump through an air inlet pipe, so that clean air can be pumped in to mix the diluted radio-pharmaceuticals.

[0008] An ultrasonic liquid level meter and a plastic scintillator detector are arranged above the radio-pharmaceutical storage tank, the measuring head of the ultrasonic liquid level meter and the detection head of the plastic scintillator detector are arranged to extend into the radio-pharmaceutical storage tank, the ultrasonic liquid level meter is used to measure the liquid level of the radio-pharmaceuticals in the radio-pharmaceutical storage tank, and the plastic scintillator detector is used to measure the radioactivity of the radio-pharmaceuticals in the radio-pharmaceutical storage tank.

[0009] The Geiger counter is used for measuring the radioactivity of the medicament in the medicine cup; the master control module stores a medical radioisotope database to identify and decay correct the medicament nuclide in the medicine tank.

[0010] The ultrasonic liquid level meter, the plastic flash detector and the Geiger counter are connected with the master control module, so that the ultrasonic liquid level meter, the plastic flash detector and the Geiger counter can transmit the measurement data to the master control module, and the radioactivity of the medicament in the medicine tank and the medicine cup is obtained by combining the passive efficiency calibration, so that the radioactivity concentration of the medicament in the medicine tank and the medicine cup is obtained, and whether the medicament in the medicine tank is mixed uniformly is judged.

[0011] The master control template is connected with the air pump to control the opening and closing of the air pump; an electromagnetic valve is arranged at the medicine outlet, and the master control template is connected with the electromagnetic valve to control the electromagnetic valve in real time by the feedback signal of the ultrasonic liquid level meter to control the medicine amount under the condition that the medicament in the medicine tank is mixed uniformly.

[0012] The power module is connected with the ultrasonic liquid level meter, the plastic flash detector, the Geiger counter, the air pump, the electromagnetic valve, the master control module and the display module to provide electric energy, and the master control module is connected with the display module.

[0013] Further, the inner wall of the medicine tank is coated with a hydrophobic material to form a hydrophobic coating on the inner wall of the medicine tank.

[0014] Further, the medicine tank is arranged in a room, the master control module and the display module are arranged outside the room, and a ring-shaped lead shielding sleeve is arranged outside the medicine tank.

[0015] Further, a medicine cavity is arranged at the medicine outlet of the medicine tank, a first camera and a lighting lamp are arranged in the medicine cavity, the first camera and the lighting lamp are connected with the master control module to control the opening and closing of the first camera and the lighting lamp, and the video data collected by the first camera is transmitted to the display module.

[0016] Further, a second camera is arranged in the room, the second camera is connected with the master control module to control the opening and closing of the second camera, and the video data collected by the second camera is transmitted to the display module.

[0017] The application also provides a radioactive medicament dispensing method, which adopts the above-mentioned radioactive medicament dispensing system for dispensing, and specifically includes the following steps:

[0018] (1) Based on the Monte Carlo method, the medicine tank and the medicine cup are simulated and calculated respectively to obtain the normalized dose rate of different volumes of medicament, so as to complete the passive efficiency calibration of the medicine tank and the medicine cup.

[0019] (2) add high-concentration medicament into the medicament storage tank, and then add distilled water; start the air pump to pump clean air into the medicament storage tank, and stir the medicament and distilled water in the medicament storage tank;

[0020] (3) after a period of time, close the air pump, obtain the liquid level L1 of the medicament in the medicament storage tank through the ultrasonic liquid level meter, control the electromagnetic valve to discharge a small amount of medicament to the medicine cup, and then close the electromagnetic valve;

[0021] (4) obtain the liquid level L2 of the remaining medicament in the medicament storage tank through the ultrasonic liquid level meter, so as to obtain the volume V1 of the remaining medicament in the medicament storage tank, measure the radioactivity A1 of the remaining medicament in the medicament storage tank through the plastic flash detector and in combination with the passive efficiency calibration factor of the medicament storage tank;

[0022] measure the radioactivity A2 of the medicament in the medicine cup through the Geiger counter and in combination with the passive efficiency calibration factor of the medicine cup; and calculate the volume V2 of the medicament in the medicine cup through the liquid level difference twice;

[0023] If the radioactivity A1 of the remaining medicament in the medicament storage tank is equal to the radioactivity A2 of the medicament in the medicine cup, it indicates that the medicament in the medicament storage tank is uniformly mixed, and then step (6) is entered, otherwise, step (5) is entered;

[0024] (5) start the air pump to pump clean air into the medicament storage tank, and repeat steps (3) and (4);

[0025] (6) according to the prescription dose of the patient, control the electromagnetic valve to control the amount of medicament according to the gravity flow model.

[0026] Further, each time the medicament is given, if the radioactivity A1 of the remaining medicament in the medicament storage tank is equal to the radioactivity A2 of the medicament in the medicine cup, the patient takes the medicament normally, otherwise, the patient suspends taking the medicament, and the medical staff is reminded to troubleshoot. Wherein A 实 = a 1实 + a 2实 , A 理 is the theoretical value of the radioactivity of the medicament in the medicament storage tank before the medicament is given, a 1实 is the measured value of the remaining radioactivity of the medicament in the medicament storage tank after the medicament is given, and a 2实 is the measured value of the radioactivity of the medicament in the medicine cup after the medicament is given.

[0027] Compared with the prior art, the present application has the following beneficial effects:

[0028] 1. The present application sets an air inlet on the medicament storage tank, and clean air is introduced into the medicament storage tank, so that the clean air can generate a vortex flow in the medicament in the medicament storage tank, thereby efficiently mixing the medicament and distilled water, and ensuring the uniformity of the medicament in the medicament storage tank.

[0029] ​2、The present application adopts plastic flash detector and Geiger counter to measure the radioactivity intensity of radioactive medicament in the medicament storage tank and medicine cup in real time, and combines with the Monte Carlo passive efficiency calibration result to obtain the measured radioactivity activity of the radioactive medicament in the medicament storage tank and medicine cup, thereby effectively detecting the uniformity of medicament in the medicament storage tank, and greatly improving the accuracy of drug administration.

[0030] 3、The present application compares the theoretical radioactivity activity of medicament in the medicament storage tank before administration with the sum of the actual remaining radioactivity activity of medicament in the medicament storage tank after administration and the actual radioactivity activity in the medicine cup, thereby realizing effective quality control and ensuring the accuracy of drug administration. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1 The control flowchart of the present application.

[0032] Wherein: 1-medicament storage tank; 2-electromagnetic valve; 3-Geiger counter; 4-medicine cup; 5-second camera; 6-first camera; 7-anti-fog lighting lamp; 8-display module; 9-main control module; 10-power module; 11-ultrasonic liquid level meter; 12-plastic flash detector; N1-water inlet; N2-air inlet; N3-medicament inlet. DETAILED DESCRIPTION

[0033] The present application will be further described in detail below in combination with the drawings and specific embodiments.

[0034] Reference Figure 1 , the solid line is the power supply line, and the dashed line is the control line, a radioactive medicament dispensing system, comprising a medicament storage tank 1 and a medicine cup 4, the medicament storage tank 1 is provided with a medicament inlet N3, a water inlet N1, an air inlet N2 and a drug administration port, the medicament inlet N3 is used for adding medicament, and the water inlet N1 is used for adding distilled water; the air inlet N2 is connected with an air pump and an air inlet filter core through an air inlet pipe, which is convenient for pumping clean air to mix the diluted medicament in the medicament storage tank.

[0035] The ultrasonic liquid level meter 11 and the plastic flash detector 12 are arranged above the medicament storage tank 1, and the measurement head of the ultrasonic liquid level meter and the detection head of the plastic flash detector extend into the medicament storage tank, the ultrasonic liquid level meter 11 is used for measuring the liquid level of the medicament in the medicament storage tank 1, and the plastic flash detector 12 is used for measuring the radioactivity activity of the medicament in the medicament storage tank 1.

[0036] It also includes a Geiger counter 3, a main control module 9, a display module 8 and a power module 10, the Geiger counter 3 is used for measuring the radioactivity activity of the medicament in the medicine cup 4, the main control module 9 stores a medical radioactive isotope database to identify and decay correct the medicament nuclide in the medicament storage tank 1.

[0037] The ultrasonic liquid level meter 11, the plastic flash detector 12 and the Geiger counter 3 are connected with the main control module 9, so that the ultrasonic liquid level meter 11, the plastic flash detector 12 and the Geiger counter 3 can transmit the measurement data to the main control module 9, and the measured value of the radioactivity of the medicament in the medicament storage tank 1 and the medicine cup 4 is obtained by combining the passive efficiency calibration, so that the radioactivity concentration of the medicament in the medicament storage tank 1 and the medicine cup 4 is obtained, and then whether the medicament in the medicament storage tank 1 is mixed uniformly is judged.

[0038] The main control template 9 is connected with the air pump to control the opening and closing of the air pump; the electromagnetic valve 2 is arranged at the drug administration port, and the main control template 9 is connected with the electromagnetic valve 2 to control the drug administration amount in real time by the feedback signal of the ultrasonic liquid level meter 11 under the condition that the medicament in the medicament storage tank 1 is mixed uniformly.

[0039] The power module 10 is connected with the ultrasonic liquid level meter 11, the plastic flash detector 12, the Geiger counter 3, the air pump, the electromagnetic valve 2, the main control module 9 and the display module 8 to provide electric energy, and the main control module 9 is connected with the display module 8 to display the measurement data of the ultrasonic liquid level meter 11, the plastic flash detector 12 and the Geiger counter 3 and the calculation result of the main control module 9.

[0040] Here, the ultrasonic liquid level meter is used to measure the volume of the medicament in the medicament storage tank, so that the non-contact measurement is realized, and compared with the contact type liquid level measurement, the probability of radioactive contamination is greatly reduced.

[0041] The air inlet is arranged on the medicament storage tank, clean air is pumped into the medicament storage tank, the clean air can generate vortex flow in the medicament in the medicament storage tank, so that the medicament and distilled water are fully stirred, and then the medicament and distilled water can be efficiently mixed, so that the uniformity of the medicament in the medicament storage tank is ensured.

[0042] The plastic flash detector and the Geiger counter are used to obtain the radioactivity of the medicament in the medicament storage tank and the medicine cup in real time, but because the radioactive measurement is affected by the geometric shape of the radioactive source, for example, the rays released by the radioactive nucleus decay located at the center of the medicament storage tank and the rays released by the nucleus decay located at the wall of the medicament storage tank are different from the case of reaching the detector, and different shapes of the medicament storage tank, such as cylinder and sphere, cuboid, etc. are also different. Therefore, the Monte Carlo method is used to simulate and simulate the medicament storage tank and the medicine cup respectively, to calculate the normalized dose rate of different volumes of medicament, so as to complete the passive efficiency calibration of the medicament storage tank and the medicine cup, and then the radioactivity of the medicament in the medicament storage tank and the medicine cup can be inversely deduced according to the measurement data of the plastic flash detector and the Geiger counter, so as to obtain the radioactivity concentration of the medicament in the medicament storage tank and the medicine cup, and then the uniformity of the medicament in the medicament storage tank can be effectively detected, and the drug administration accuracy can be greatly improved.

[0043] In practice, the inner wall of the medicine storage tank 1 is coated with a hydrophobic material, thereby forming a hydrophobic coating on the inner wall of the medicine storage tank 1.

[0044] The hydrophobic coating effectively reduces drug residue adhering to the walls and prevents uncontrolled dilution of the drug during subsequent dispensing. As shown in the figure, the bottom of the drug storage tank is inverted conical, with the inlet located at the bottom of the conical shape, facilitating smooth drug flow during administration. Furthermore, the hydrophobic coating further reduces radiation levels within the equipment's interior, improving maintainability.

[0045] In practice, the medicine storage tank 1 is located inside the room, while the main control module 9 and the display module 8 are located outside the room, and the medicine storage tank 1 is provided with an independent annular lead shielding sleeve.

[0046] A lead shielding sleeve is installed around the outside of the drug storage tank, with the lead shielding layer arranged in a ring around the perimeter of the tank. This is equivalent to an independent shielding design for the drug storage tank. Compared to the existing technology of adding a plate-like shield to the entire equipment shell, this reduces the overall weight of the equipment and provides a low-radiation environment for the internal space, preventing internal components (such as solenoid valves) from being exposed to high radiation for extended periods. This reduces the failure rate of electronic components and increases the reliability of the equipment, while also improving its maintainability. Furthermore, the main control module and display module are located outside the room, facilitating remote operation of the system by medical personnel.

[0047] In specific implementation, the medicine storage tank 1 has a drug delivery chamber at the drug delivery port. The drug delivery chamber is equipped with a first camera 6 and an anti-fog light 7. The first camera 6 and the anti-fog light 7 are connected to the main control module 9 so that the main control module can control the opening and closing of the first camera 6 and the anti-fog light 7, and at the same time transmit the video data collected by the first camera 6 to the display module 8.

[0048] When a patient comes to the room to collect their medication, the medicine cup is first placed below the administration port, and then the shielding door at the administration port is closed. At this time, medical staff will operate the system, turning on the first camera, the anti-fog light, and the solenoid valve to observe whether the medication flows out smoothly and whether it all enters the medicine cup, in order to ensure the safety and accuracy of medication administration.

[0049] In specific implementation, a second camera 5 is installed in the room. The second camera 5 is connected to the main control module 9 so that the main control module 9 can control the second camera 5 to open and close, and at the same time transmit the video data collected by the second camera 5 to the display module 8.

[0050] A second camera is installed here so that medical staff can monitor and guide patients on how to properly dispense their medication using the video data collected by the second camera.

[0051] A radioactive agent dispensing method is disclosed, which is performed by using the radioactive agent dispensing system as described above, and specifically includes the following steps:

[0052] (1) Based on the Monte Carlo method, the medicament tank and the medicine cup are simulated respectively, the normalized dose rate of different volumes of medicaments is calculated, and the passive efficiency calibration of the medicament tank and the medicine cup is completed;

[0053] (2) High-concentration medicaments are added to the medicament tank, and then distilled water is added; the air pump is started to pump clean air into the medicament tank, and the medicaments and distilled water in the medicament tank are stirred and mixed;

[0054] (3) After a period of time, the air pump is turned off, the liquid level L1 of the medicaments in the medicament tank is obtained by the ultrasonic liquid level meter, the electromagnetic valve is controlled to discharge a small amount of medicaments to the medicine cup, and then the electromagnetic valve is closed;

[0055] (4) The liquid level L2 of the remaining medicaments in the medicament tank is obtained by the ultrasonic liquid level meter, so as to obtain the volume V1 of the remaining medicaments in the medicament tank, and the radioactivity A1 of the remaining medicaments in the medicament tank is measured by the plastic scintillator detector combined with the passive efficiency calibration factor of the medicament tank;

[0056] The radioactivity A2 of the medicaments in the medicine cup is measured by the Geiger counter combined with the passive efficiency calibration factor of the medicine cup, and the volume V2 of the medicaments in the medicine cup is calculated by the difference between the two liquid levels;

[0057] If It is indicated that the medicaments in the medicament tank are uniformly mixed, and step (6) is entered, otherwise, step (5) is entered;

[0058] (5) The air pump is started to pump clean air into the medicament tank, and steps (3) and (4) are repeated

[0059] (6) According to the prescription dose of the patient, the electromagnetic valve is controlled to control the amount of medicaments according to the gravity flow model.

[0060] Here, the clean air mixed with the medicaments in step (3) can ensure a long enough time to fully stir the medicaments after the clean air is pumped in once, to ensure the uniformity of the medicaments and reduce the waste of the medicaments. Of course, in actual application, the corresponding empirical value can be obtained according to the mixing time required by different radioactive medicaments, so as to be used next time when mixing the medicaments. When the actual radioactivity concentration of the medicaments in the medicament tank = the actual radioactivity concentration of the medicaments in the medicine cup, it is indicated that the medicaments in the medicament tank are uniformly mixed, and the patient can be given medicaments, so that the uniformity of the medicaments is verified by actual measurement, and the accuracy of the administration can be effectively improved.

[0061] Simultaneously, radioactive decay must be considered during drug administration, so decay correction is necessary. Specifically, if the initial radioactivity of the drug is a0, and the time interval between testing the homogeneity of drug mixing and loading is t1, then the radioactivity of the remaining drug in the storage tank at the time of testing the homogeneity of drug mixing is... If the radioactivity of the reagent used to test the uniformity of reagent mixing is a1, then the remaining radioactivity in the reagent storage tank at this time is... If the time interval between the first patient taking the medication and the time interval for testing the homogeneity of the drug mixture is t2, then the radioactivity of the remaining medication in the storage tank when the first patient was given the medication is: The first patient took the medication with a radioactivity level of a2. What is the remaining radioactivity level in the medication storage tank at this time? If the time interval between the second patient's medication administration and the first patient's medication administration is t3, then when the second patient receives their medication, the radioactivity of the remaining medication in the storage tank is: The second patient took a drug with a radioactivity level of a3. What is the remaining radioactivity level in the drug storage tank at this time? This process is repeated for multiple patients. When a high concentration of medication needs to be added to the medication storage tank, the medication administration is paused. After adding the high concentration of medication, clean air is introduced to mix the medication, and the uniformity of the mixture is checked before the medication administration is resumed.

[0062] In practice, each time the medication is administered, if... Where A 实 =a 1实 +a 2实 A 理 a is the theoretical value of the radioactivity of the drug in the storage tank before administration. 1实 a is the measured value of the residual radioactivity of the drug in the drug storage tank after administration. 2实 If the measured value of the radioactivity of the medication in the medicine cup after administration indicates that the patient has taken the medication normally, then the patient has taken the medication normally. Otherwise, it indicates that there is a problem such as medication leakage or residue. The patient should stop taking the medication and be asked to leave the room immediately. Medical staff should be reminded to troubleshoot the problem.

[0063] As described above, The calculation results, etc., all represent the theoretical values ​​of the radioactivity of the drug in the storage tank before each administration. 1实 The residual radioactivity intensity of the drug in the storage tank after administration is obtained using a plastic scintillator, and the measured value is obtained by combining it with the passive efficiency calibration of the drug storage tank; while a 2实 The radioactivity intensity of the reagent in the medicine cup is obtained by using a Geiger counter, and the measured value is obtained by combining the passive efficiency scale of the medicine cup.

[0064] The set threshold value is set according to the requirement, so that effective quality control is performed on each administration, and the accuracy of administration is ensured.

[0065] Finally, it should be noted that the above embodiments of the present application are only examples for illustrating the present application, and are not intended to limit the embodiments of the present application. Based on the above description, other different forms of changes and variations can be made by those skilled in the art. All the embodiments cannot be exhausted here. Any obvious changes or variations derived from the technical solutions of the present application are still within the protection scope of the present application.

Claims

1. A method for dispensing radioactive agents, characterized in that, A radioactive agent dispensing system is used for dispensing. The dispensing system includes an agent storage tank and an agent cup. The agent storage tank is equipped with a drug addition port, a water addition port, an air inlet, and a drug delivery port. The drug addition port is used to add the agent, and the water addition port is used to add distilled water. The air inlet is connected to an air pump through an air inlet pipe to facilitate the pumping of clean air to mix the diluted agent. An ultrasonic level gauge and a plastic scintillator are installed above the pharmaceutical storage tank, with the measuring head of the ultrasonic level gauge and the probe head of the plastic scintillator extending into the pharmaceutical storage tank. The ultrasonic level gauge is used to measure the liquid level of the pharmaceutical in the storage tank; the plastic scintillator is used to measure the radioactivity of the pharmaceutical in the storage tank. It also includes a Geiger counter, a main control module, a display module, and a power supply module. The Geiger counter is used to measure the radioactivity of the medicine in the medicine cup. The main control module stores a medical radioisotope database to identify and correct the decay of the medicine nuclides in the medicine storage tank. The ultrasonic level gauge, plastic scintillator, and Geiger counter are all connected to the main control module, which facilitates the transmission of measurement data from the ultrasonic level gauge, plastic scintillator, and Geiger counter to the main control module. Combined with the passive efficiency scale, the radioactivity of the reagent in the reagent storage tank and reagent cup is obtained, thereby obtaining the radioactivity concentration of the reagent in the reagent storage tank and reagent cup, and further determining whether the reagent in the reagent storage tank is mixed evenly. The main control module is connected to the air pump to control the air pump's start and stop; a solenoid valve is installed at the drug delivery port, and the main control module is connected to the solenoid valve to control the drug delivery amount in real time by using the feedback signal from the ultrasonic level gauge when the drug is evenly mixed in the drug storage tank. The power module is connected to the ultrasonic level gauge, plastic scintillator, Geiger counter, air pump, solenoid valve, main control module and display module to provide power. The main control module is connected to the display module. Specifically, the following steps are included: (1) Based on the Monte Carlo method, the drug storage tank and the drug cup are simulated respectively, and the normalized dose rate of different volumes of drugs is calculated, so as to complete the passive efficiency calibration of the drug storage tank and the drug cup. (2) Add the high-concentration agent to the agent storage tank, and then add distilled water; start the air pump to pump clean air into the agent storage tank and stir and mix the agent and distilled water in the agent storage tank; (3) After a period of time, turn off the air pump, obtain the liquid level L1 of the medicine in the medicine storage tank through the ultrasonic level gauge, control the solenoid valve, release a small amount of medicine into the medicine cup, and then close the solenoid valve. (4) Obtain the liquid level L2 of the remaining drug in the drug storage tank by using an ultrasonic level gauge, thereby obtaining the volume V1 of the remaining drug in the drug storage tank. Measure the radioactivity A1 of the remaining drug in the drug storage tank by using a plastic scintillator and combining it with the passive efficiency scale factor of the drug storage tank. The radioactivity A2 of the reagent in the reagent cup was measured using a Geiger counter and a passive efficiency scale factor; the volume V2 of the reagent in the reagent cup was calculated using the difference between two liquid levels. like If the drug in the storage tank is mixed evenly, proceed to step (6); otherwise, proceed to step (5). (5) Turn on the air pump to pump clean air into the drug storage tank, and repeat steps (3) and (4). (6) The dosage is controlled by the solenoid valve according to the patient's prescription dosage and the gravity flow model.

2. The method for dispensing radiopharmaceuticals according to claim 1, characterized in that, Each time the medication is administered, if, Where A 实 =a 1实 +a 2实 A 理 a is the theoretical value of the radioactivity of the drug in the storage tank before administration. 1实 a is the measured value of the residual radioactivity of the drug in the drug storage tank after administration. 2实 If the measured value of the radioactivity of the medication in the medicine cup after administration is given, the patient should take the medication normally; otherwise, the patient should stop taking the medication, and the medical staff should be reminded to troubleshoot the problem.

3. The method for dispensing radiopharmaceuticals according to claim 1, characterized in that, The inner wall of the pharmaceutical storage tank is coated with a hydrophobic material, thereby forming a hydrophobic coating on the inner wall of the pharmaceutical storage tank.

4. The method for dispensing radiopharmaceuticals according to claim 1, characterized in that, The medicine storage tank is located inside the room, while the main control module and display module are located outside the room, and the medicine storage tank is equipped with an annular lead shielding sleeve.

5. A method for dispensing radiopharmaceuticals according to claim 4, characterized in that, The drug storage tank has a drug delivery chamber at the drug delivery port. A first camera and a light are installed in the drug delivery chamber. The first camera and the light are connected to the main control module to control the opening and closing of the first camera and the light, and at the same time, the video data collected by the first camera is transmitted to the display module.

6. A method for dispensing radiopharmaceuticals according to claim 4, characterized in that, The room is equipped with a second camera, which is connected to the main control module to control the opening and closing of the second camera and transmit the video data collected by the second camera to the display module.

Citation Information

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